Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ACOT7	11332	broad.mit.edu	37	1	6445619	6445619	+	Silent	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:6445619G>A	uc001ams.2	-	1	265	c.108C>T	c.(106-108)TGC>TGT	p.C36C	ACOT7_uc010nzq.1_Intron|ACOT7_uc001amt.2_Intron|ACOT7_uc001amu.2_Intron|ACOT7_uc001amv.2_Intron	NM_181864	NP_863654	O00154	BACH_HUMAN	acyl-CoA thioesterase 7 isoform hBACHb	36						mitochondrion|nucleus	carboxylesterase activity|fatty-acyl-CoA binding|palmitoyl-CoA hydrolase activity				0	Ovarian(185;0.0634)|all_lung(157;0.175)	all_cancers(23;1.42e-38)|all_epithelial(116;3.96e-23)|all_lung(118;3.69e-08)|Lung NSC(185;8.52e-07)|all_hematologic(16;6.92e-06)|Colorectal(325;4.53e-05)|Acute lymphoblastic leukemia(12;5e-05)|all_neural(13;0.000164)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;9.16e-37)|GBM - Glioblastoma multiforme(13;5.89e-29)|OV - Ovarian serous cystadenocarcinoma(86;7.63e-19)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;2.06e-05)|Kidney(185;7.74e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00129)|BRCA - Breast invasive adenocarcinoma(365;0.00132)|STAD - Stomach adenocarcinoma(132;0.00195)|READ - Rectum adenocarcinoma(331;0.0481)		GGACGGGAGCGCAGCACCCTC	0.632													4	318					0	0	0.000602	0	0
NBPF1	55672	broad.mit.edu	37	1	16893781	16893781	+	Missense_Mutation	SNP	T	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:16893781T>G	uc009vos.1	-	26	3845	c.2957A>C	c.(2956-2958)TAT>TCT	p.Y986S	NBPF1_uc009vot.1_Missense_Mutation_p.Y369S|NBPF1_uc001ayz.1_Missense_Mutation_p.Y369S|NBPF1_uc010oce.1_Missense_Mutation_p.Y640S	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	986	NBPF 6.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		AGGAGTTGAATAACATCTATC	0.488													5	732					0	0	0.003080	0	0
C1QC	714	broad.mit.edu	37	1	22974057	22974057	+	Silent	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:22974057G>A	uc001bgc.3	+	3	622	c.519G>A	c.(517-519)TCG>TCA	p.S173S	C1QC_uc001bga.3_Silent_p.S173S|C1QC_uc001bgb.2_Silent_p.S173S	NM_172369	NP_758957	P02747	C1QC_HUMAN	complement component 1, q subcomponent, C chain	173	C1q.				complement activation, classical pathway|innate immune response|negative regulation of granulocyte differentiation|negative regulation of macrophage differentiation	collagen					0		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.21e-27)|Colorectal(126;1.5e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.61e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000538)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.196)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ACCACGCGTCGCATACAGCCA	0.582													4	264					0	0	0.000602	0	0
MMACHC	25974	broad.mit.edu	37	1	45974804	45974804	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:45974804G>A	uc009vxv.2	+	4	915	c.766G>A	c.(766-768)GCC>ACC	p.A256T	MMACHC_uc001cny.2_RNA	NM_015506	NP_056321	Q9Y4U1	MMAC_HUMAN	methylmalonic aciduria (cobalamin deficiency)	256							cobalamin binding				0	Acute lymphoblastic leukemia(166;0.155)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TACCACACCCGCCCCCAAGAA	0.622													5	556					0	0	0.001984	0	0
GSTM2	2946	broad.mit.edu	37	1	110217448	110217448	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:110217448G>A	uc001dyi.2	+	8	961	c.647G>A	c.(646-648)GGC>GAC	p.G216D	GSTM2_uc001dyj.2_Missense_Mutation_p.G216D|GSTM2_uc010ovt.1_Intron|GSTM2_uc009wfk.2_Intron	NM_000848	NP_000839	P28161	GSTM2_HUMAN	glutathione S-transferase mu 2 isoform 1	216					glutathione metabolic process|xenobiotic catabolic process	cytoplasm	glutathione transferase activity				0		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0122)|Colorectal(144;0.0129)|Epithelial(280;0.0146)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.047)|LUSC - Lung squamous cell carcinoma(189;0.227)	Glutathione(DB00143)	GCTGTCTGGGGCAACAAGTAG	0.587													4	332					0	0	0.001168	0	0
PDE4DIP	9659	broad.mit.edu	37	1	145075693	145075693	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:145075693G>A	uc001emh.2	-	1	387	c.170C>T	c.(169-171)GCC>GTC	p.A57V	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elo.2_Missense_Mutation_p.A57V|PDE4DIP_uc001emk.2_Missense_Mutation_p.A57V	NM_022359	NP_071754	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CCAGCTCCCGGCTGGCTCCGG	0.726			T	PDGFRB	MPD								4	321					0	0	0.000602	0	0
NBPF10	100132406	broad.mit.edu	37	1	145359175	145359175	+	Missense_Mutation	SNP	G	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:145359175G>C	uc001end.3	+	74	9375	c.9340G>C	c.(9340-9342)GTT>CTT	p.V3114L	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron|NBPF10_uc001enc.2_Intron|NBPF10_uc010oyq.1_Intron|NBPF10_uc010oyr.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3039											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TGGCTTGGCTGTTGACATGGA	0.463													4	608					0	0	0.009096	0	0
ADAR	103	broad.mit.edu	37	1	154574460	154574460	+	Missense_Mutation	SNP	C	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:154574460C>A	uc001ffh.2	-	2	858	c.658G>T	c.(658-660)GCC>TCC	p.A220S	ADAR_uc001ffj.2_Missense_Mutation_p.A220S|ADAR_uc001ffi.2_Missense_Mutation_p.A220S|ADAR_uc001ffk.2_5'UTR|ADAR_uc001ffl.1_5'UTR	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	220					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		GAGTTTGGGGCTCCTTGGCTA	0.527													5	327					5.50884e-06	5.84889e-06	0.013537	1	0
ADAR	103	broad.mit.edu	37	1	154574475	154574475	+	Missense_Mutation	SNP	C	T	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:154574475C>T	uc001ffh.2	-	2	843	c.643G>A	c.(643-645)GGT>AGT	p.G215S	ADAR_uc001ffj.2_Missense_Mutation_p.G215S|ADAR_uc001ffi.2_Missense_Mutation_p.G215S|ADAR_uc001ffk.2_5'UTR|ADAR_uc001ffl.1_5'UTR	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	215					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		TGGCTATGACCGTCTGGTCTT	0.522													5	339					0	0	0.010729	0	0
DCST1	149095	broad.mit.edu	37	1	155018875	155018875	+	Missense_Mutation	SNP	C	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:155018875C>G	uc001fgn.1	+	13	1504	c.1408C>G	c.(1408-1410)CTG>GTG	p.L470V	DCST1_uc010per.1_Missense_Mutation_p.L495V|DCST1_uc010pes.1_Missense_Mutation_p.L445V|uc001fgo.2_Intron	NM_152494	NP_689707	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1 isoform 1	470	Helical; (Potential).					integral to membrane	zinc ion binding			ovary(1)|skin(1)	2	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			TCTGCTGCTGCTGGTGGTGCT	0.627													4	309					0	0	0.001168	0	0
KIAA0907	22889	broad.mit.edu	37	1	155887399	155887399	+	Missense_Mutation	SNP	T	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:155887399T>G	uc001fmi.1	-	11	1355	c.1331A>C	c.(1330-1332)CAG>CCG	p.Q444P	KIAA0907_uc001fmj.1_Missense_Mutation_p.Q444P|KIAA0907_uc009wrk.1_Missense_Mutation_p.Q301P|KIAA0907_uc009wrl.1_RNA	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	444	Pro-rich.										0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			gggctggggctggggGCCAGC	0.443													24	137					0	0	0.007835	0	0
CADM3	57863	broad.mit.edu	37	1	159161805	159161805	+	Silent	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:159161805G>A	uc001ftl.2	+	2	310	c.168G>A	c.(166-168)GAG>GAA	p.E56E	CADM3_uc009wsx.1_Silent_p.E90E|CADM3_uc009wsy.1_Silent_p.E56E|CADM3_uc001ftk.2_Silent_p.E90E	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	56	Ig-like V-type.|Extracellular (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)					AAGATCACGAGGACTCATCCC	0.507													3	152					0	0	0.004672	0	0
ADCY10	55811	broad.mit.edu	37	1	167825553	167825553	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:167825553G>A	uc001ger.2	-	17	2319	c.2021C>T	c.(2020-2022)CCC>CTC	p.P674L	ADCY10_uc009wvk.2_Missense_Mutation_p.P582L|ADCY10_uc010plj.1_Missense_Mutation_p.P521L|ADCY10_uc009wvl.2_Missense_Mutation_p.P673L	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	674					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						GTTAACGAAGGGACACAGGGA	0.468													5	465					0	0	0.001168	0	0
F5	2153	broad.mit.edu	37	1	169510502	169510502	+	Missense_Mutation	SNP	G	T	T	rs140018525	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:169510502G>T	uc001ggg.1	-	13	3971	c.3826C>A	c.(3826-3828)CTT>ATT	p.L1276I		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1276	2-11.|35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T.|B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TCTGGAGAAAGGGGCATCTGA	0.502													7	855					3.08376e-08	3.29445e-08	0.003330	1	0
CACNA1E	777	broad.mit.edu	37	1	181680116	181680116	+	Missense_Mutation	SNP	T	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:181680116T>A	uc001gow.2	+	8	1247	c.1082T>A	c.(1081-1083)GTG>GAG	p.V361E	CACNA1E_uc009wxs.2_Missense_Mutation_p.V268E	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	361	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						AGAGAGAGAGTGGAGAACCGA	0.522													4	307					0	0	0.001984	0	0
PRG4	10216	broad.mit.edu	37	1	186276961	186276961	+	Missense_Mutation	SNP	A	C	C	rs145338869	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:186276961A>C	uc001gru.3	+	7	2161	c.2110A>C	c.(2110-2112)ACT>CCT	p.T704P	PRG4_uc001grt.3_Missense_Mutation_p.T663P|PRG4_uc009wyl.2_Missense_Mutation_p.T611P|PRG4_uc009wym.2_Missense_Mutation_p.T570P|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	704	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|42; approximate.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CCCTAAGGAGACTGCTCCAAC	0.597													5	357					0	0	0.001168	0	0
FMOD	2331	broad.mit.edu	37	1	203316732	203316732	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:203316732G>A	uc001gzr.2	-	2	803	c.667C>T	c.(667-669)CGG>TGG	p.R223W	FMOD_uc010pqi.1_RNA	NM_002023	NP_002014	Q06828	FMOD_HUMAN	fibromodulin precursor	223					transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				ovary(2)|breast(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.171)			ATCAGTGACCGGAGGCCCCTC	0.562													5	423					0	0	0.000602	0	0
PPP1R15B	84919	broad.mit.edu	37	1	204380470	204380470	+	Missense_Mutation	SNP	A	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:204380470A>G	uc001hav.3	-	1	475	c.70T>C	c.(70-72)TTT>CTT	p.F24L		NM_032833	NP_116222	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	24					regulation of translation					ovary(1)|pancreas(1)	2	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			CGAGGGAAAAAGGGTGGCCAG	0.627													4	299					0	0	0.000602	0	0
FMN2	56776	broad.mit.edu	37	1	240371421	240371421	+	Silent	SNP	C	T	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:240371421C>T	uc010pyd.1	+	5	3534	c.3309C>T	c.(3307-3309)CCC>CCT	p.P1103P	FMN2_uc010pye.1_Silent_p.P1107P	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1103	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCCCTCTACCCGGAGTGGGCA	0.736													11	144					0	0	0.002450	0	0
KIAA1217	56243	broad.mit.edu	37	10	24669920	24669920	+	Silent	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:24669920T>C	uc001iru.3	+	3	880	c.477T>C	c.(475-477)CCT>CCC	p.P159P	KIAA1217_uc001irs.2_Silent_p.P79P|KIAA1217_uc001irt.3_Silent_p.P159P|KIAA1217_uc010qcy.1_Silent_p.P159P|KIAA1217_uc010qcz.1_Silent_p.P159P|KIAA1217_uc001irv.1_Silent_p.P9P|KIAA1217_uc010qda.1_RNA	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	159					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						CTCCAACCCCTTTTTCCAGAG	0.542													4	229					0	0	0.000602	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37430707	37430707	+	Silent	SNP	A	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:37430707A>G	uc001iza.1	+	7	813	c.714A>G	c.(712-714)ACA>ACG	p.T238T		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	294						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CACCTGACACAGCTGAAAGCT	0.463													4	155					0	0	0.009096	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37431050	37431050	+	Missense_Mutation	SNP	G	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:37431050G>C	uc001iza.1	+	7	1156	c.1057G>C	c.(1057-1059)GCA>CCA	p.A353P		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	409						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						ATTTACGTGGGCAGCAAAAGG	0.408													4	318					0	0	0.000602	0	0
HKDC1	80201	broad.mit.edu	37	10	71010157	71010157	+	Missense_Mutation	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:71010157T>C	uc001jpf.3	+	11	1815	c.1682T>C	c.(1681-1683)ATC>ACC	p.I561T	HKDC1_uc010qje.1_Missense_Mutation_p.I424T	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	561					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5						ATCTTCGCCATCCCCCTGGAG	0.592													4	286					0	0	0.000602	0	0
FAM190B	54462	broad.mit.edu	37	10	86198326	86198326	+	Missense_Mutation	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:86198326T>C	uc001kdh.1	+	6	2121	c.1927T>C	c.(1927-1929)TTT>CTT	p.F643L	FAM190B_uc010qmd.1_Missense_Mutation_p.F643L|FAM190B_uc001kdi.1_Intron|FAM190B_uc010qme.1_Missense_Mutation_p.F70L	NM_018999	NP_061872	Q9H7U1	F190B_HUMAN	granule cell antiserum positive 14	643										ovary(3)|skin(1)	4						AGGGATGCCCTTTTTCCAGGC	0.453													5	374					0	0	0.000602	0	0
KRTAP5-3	387266	broad.mit.edu	37	11	1629152	1629152	+	Missense_Mutation	SNP	C	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:1629152C>G	uc001ltw.1	-	1	542	c.464G>C	c.(463-465)TGC>TCC	p.C155S		NM_001012708	NP_001012726	Q6L8H2	KRA53_HUMAN	keratin associated protein 5-3	155	11 X 4 AA repeats of C-C-X-P.					keratin filament				ovary(2)	2		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000618)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)		GGACTGGGAGCAGCTGGGCTT	0.388													4	831					0	0	0.000602	0	0
ZNF195	7748	broad.mit.edu	37	11	3380678	3380678	+	Silent	SNP	C	T	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:3380678C>T	uc001lxt.2	-	6	1738	c.1560G>A	c.(1558-1560)AAG>AAA	p.K520K	uc001lxr.2_5'Flank|ZNF195_uc001lxv.2_Silent_p.K497K|ZNF195_uc001lxs.2_Silent_p.K448K|ZNF195_uc010qxr.1_Silent_p.K501K|ZNF195_uc009ydz.2_Silent_p.K475K|ZNF195_uc001lxu.2_Silent_p.K452K	NM_001130520	NP_001123992	O14628	ZN195_HUMAN	zinc finger protein 195 isoform 1	520					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		ATTTGTAGGGCTTCTCTCCAG	0.403													9	581					0	0	0.004482	0	0
TSG101	7251	broad.mit.edu	37	11	18505466	18505466	+	Missense_Mutation	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:18505466T>C	uc001mor.2	-	8	920	c.794A>G	c.(793-795)AAG>AGG	p.K265R		NM_006292	NP_006283	Q99816	TS101_HUMAN	tumor susceptibility gene 101	265	Potential.				cell division|cellular membrane organization|endosome transport|interspecies interaction between organisms|non-lytic virus budding|protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	early endosome|late endosome membrane|multivesicular body|nucleolus|plasma membrane	calcium-dependent protein binding|DNA binding|transcription corepressor activity|ubiquitin binding|ubiquitin protein ligase binding				0						CTGGTGACCCTTTTTCAGGTC	0.438													6	836					0	0	0.001168	0	0
AHNAK	79026	broad.mit.edu	37	11	62296070	62296070	+	Missense_Mutation	SNP	A	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:62296070A>G	uc001ntl.2	-	5	6119	c.5819T>C	c.(5818-5820)GTG>GCG	p.V1940A	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1940					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CGACACATCCACATCCCCTTT	0.502													11	817					0	0	0.002450	0	0
KRTAP5-8	57830	broad.mit.edu	37	11	71249558	71249558	+	Missense_Mutation	SNP	T	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:71249558T>A	uc001oqr.1	+	1	488	c.457T>A	c.(457-459)TGC>AGC	p.C153S		NM_021046	NP_066384	O75690	KRA58_HUMAN	keratin associated protein 5-8	153	9 X 4 AA repeats of C-C-X-P.					extracellular region|keratin filament	structural constituent of epidermis				0						TAAGCCCTGCTGCTGCTCTTC	0.602													6	861					0	0	0.003080	0	0
CCDC15	80071	broad.mit.edu	37	11	124857562	124857562	+	Silent	SNP	A	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:124857562A>G	uc001qbm.3	+	8	1699	c.1440A>G	c.(1438-1440)TTA>TTG	p.L480L		NM_025004	NP_079280	Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	480						centrosome				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		AGAATTTTTTATCTAGAGACC	0.408													4	459					0	0	0.001984	0	0
Unknown	0	broad.mit.edu	37	12	31307356	31307356	+	Missense_Mutation	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:31307356T>C	uc010sjy.1	-	7	724	c.724A>G	c.(724-726)AAA>GAA	p.K242E						RecName: Full=Ovostatin homolog 1; Flags: Precursor;																		ATTTGGGTTTTCCCTTGCACA	0.383													5	63					0	0	0.000602	0	0
TROAP	10024	broad.mit.edu	37	12	49724313	49724313	+	Missense_Mutation	SNP	G	T	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:49724313G>T	uc001rtx.3	+	13	1852	c.1685G>T	c.(1684-1686)AGT>ATT	p.S562I	TROAP_uc009zlh.2_Missense_Mutation_p.S562I|TROAP_uc001rty.2_Missense_Mutation_p.S270I	NM_005480	NP_005471	Q12815	TROAP_HUMAN	tastin isoform 1	562	4 X 33 AA approximate tandem repeats.|Cys-rich.|2.				cell adhesion	cytoplasm				ovary(1)	1						TGCTGTAGGAGTGAGCCTGAG	0.592													4	237					0.00024832	0.000258855	0.009096	1	0
ZBTB39	9880	broad.mit.edu	37	12	57398104	57398104	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:57398104G>A	uc001sml.1	-	2	684	c.598C>T	c.(598-600)CCG>TCG	p.P200S	RDH16_uc010sqx.1_5'Flank	NM_014830	NP_055645	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	200	Poly-Pro.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1						GGCGGTTGCGGCAGATGCAGG	0.542													5	376					0	0	0.001984	0	0
DPY19L2	283417	broad.mit.edu	37	12	64041106	64041106	+	Missense_Mutation	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:64041106T>C	uc001srp.1	-	5	809	c.628A>G	c.(628-630)ATG>GTG	p.M210V	DPY19L2_uc009zqk.1_RNA	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	210	Helical; (Potential).				multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		AATAAATTCATTATTCCCATG	0.318													6	465					0	0	0.004007	0	0
XPOT	11260	broad.mit.edu	37	12	64812808	64812808	+	Silent	SNP	C	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:64812808C>G	uc001ssb.2	+	6	849	c.423C>G	c.(421-423)CTC>CTG	p.L141L	XPOT_uc009zqm.1_Silent_p.L51L	NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	141	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		GAGTAGATCTCTACCTGCGAA	0.398													4	446					0	0	0.001168	0	0
HSP90B1	7184	broad.mit.edu	37	12	104336889	104336889	+	Missense_Mutation	SNP	A	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:104336889A>G	uc001tkb.1	+	13	1787	c.1682A>G	c.(1681-1683)AAG>AGG	p.K561R	HSP90B1_uc010swg.1_Missense_Mutation_p.K226R|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	561					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	CTTCTGAAAAAGGGCTATGAA	0.418													4	591					0	0	0.000602	0	0
PRDM4	11108	broad.mit.edu	37	12	108138409	108138409	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:108138409G>A	uc001tmp.2	-	7	1743	c.1306C>T	c.(1306-1308)CGG>TGG	p.R436W	PRDM4_uc010sww.1_5'Flank|PRDM4_uc001tmq.2_RNA	NM_012406	NP_036538	Q9UKN5	PRDM4_HUMAN	PR domain containing 4	436	SET.				cell proliferation|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						AAGCAAGTCCGCACAGGAATG	0.463													4	291					0	0	0.009096	0	0
LOC374491	374491	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	G	G	rs3874227	by1000genomes	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr13:25161397C>G	uc001upm.2	+	8		c.921C>G			LOC374491_uc001upn.2_RNA|LOC374491_uc001upo.2_RNA					Homo sapiens mRNA; cDNA DKFZp434J0717 (from clone DKFZp434J0717).												0						TGAAACATCTCTACAACTGGA	0.343													13	98					0	0	0.002450	0	0
LOC374491	374491	broad.mit.edu	37	13	25161457	25161457	+	RNA	SNP	G	A	A	rs1851732	by1000genomes	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr13:25161457G>A	uc001upm.2	+	8		c.981G>A			LOC374491_uc001upn.2_RNA|LOC374491_uc001upo.2_RNA					Homo sapiens mRNA; cDNA DKFZp434J0717 (from clone DKFZp434J0717).												0						TTATTTATTCGATTCGTGGTA	0.378													14	71					0	0	0.006122	0	0
ADAM6	8755	broad.mit.edu	37	14	106054663	106054663	+	RNA	SNP	C	T	T	rs116634885	by1000genomes	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr14:106054663C>T	uc010tyt.1	-	3650		c.62823G>A			uc001yrs.2_RNA|uc001yrt.2_Missense_Mutation_p.V30I					Parts of antibodies, mostly variable regions.												0						AGGCATGCGACGACCACGTTC	0.632													5	214					0	0	0.006214	0	0
MEX3B	84206	broad.mit.edu	37	15	82336359	82336359	+	Silent	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr15:82336359G>A	uc002bgq.1	-	2	1167	c.852C>T	c.(850-852)TAC>TAT	p.Y284Y		NM_032246	NP_115622	Q6ZN04	MEX3B_HUMAN	mex-3 homolog B	284					protein autophosphorylation	cytoplasmic mRNA processing body|nucleus	calcium ion binding|RNA binding|zinc ion binding			breast(1)|kidney(1)	2						TGTCGTTGCGGTAGCTAGAGA	0.672													4	210					0	0	0.009096	0	0
AP3S2	10239	broad.mit.edu	37	15	90446470	90446470	+	Missense_Mutation	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr15:90446470T>C	uc002bos.3	-	5	805	c.650A>G	c.(649-651)GAT>GGT	p.D217G	C15orf38_uc002bot.1_RNA|C15orf38_uc002bou.2_Missense_Mutation_p.D217G	NM_182616	NP_872422	P59780	AP3S2_HUMAN	hypothetical protein LOC348110	Error:Variant_position_missing_in_P59780_after_alignment					intracellular protein transport|vesicle-mediated transport	cytoplasmic vesicle membrane|Golgi apparatus|membrane coat	protein transporter activity				0	Lung NSC(78;0.0181)|all_lung(78;0.0384)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.223)			CTCTGCCCCATCCCCCTGCTC	0.552													4	448					0	0	0.000602	0	0
ACSM1	116285	broad.mit.edu	37	16	20696521	20696521	+	Nonsense_Mutation	SNP	G	A	A	rs144518025		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:20696521G>A	uc002dhm.1	-	2	465	c.397C>T	c.(397-399)CGA>TGA	p.R133*	ACSM1_uc002dhn.1_RNA|ACSM1_uc010bwg.1_Nonsense_Mutation_p.R133*	NM_052956	NP_443188	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member	133					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|skin(1)	2						TGACCTGTTCGCATGCAGCCC	0.582													4	250					0	0	0.000602	0	0
ATXN2L	11273	broad.mit.edu	37	16	28845730	28845730	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:28845730G>A	uc002drc.2	+	17	2407	c.2239G>A	c.(2239-2241)GCA>ACA	p.A747T	uc010vct.1_Intron|ATXN2L_uc002drb.2_Missense_Mutation_p.A747T|ATXN2L_uc002dqy.2_Missense_Mutation_p.A747T|ATXN2L_uc002dra.2_Missense_Mutation_p.A747T|ATXN2L_uc002dqz.2_Missense_Mutation_p.A747T|ATXN2L_uc010vdb.1_Missense_Mutation_p.A753T|ATXN2L_uc002dre.2_Missense_Mutation_p.A747T|ATXN2L_uc002drf.2_Missense_Mutation_p.A156T|ATXN2L_uc002drg.2_Missense_Mutation_p.A29T	NM_007245	NP_009176	Q8WWM7	ATX2L_HUMAN	ataxin 2 related protein isoform A	747						membrane				upper_aerodigestive_tract(1)|ovary(1)	2						GTACCGGGGAGCAAAAGGTGA	0.602													4	288					0	0	0.001168	0	0
ZNF267	10308	broad.mit.edu	37	16	31927702	31927702	+	Missense_Mutation	SNP	G	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:31927702G>C	uc002ecs.3	+	4	2341	c.2132G>C	c.(2131-2133)AGT>ACT	p.S711T		NM_003414	NP_003405	Q14586	ZN267_HUMAN	zinc finger protein 267	711					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)|skin(1)	4						AGAAGTCATAGTGGAGAGAGA	0.418													3	251					0	0	0.003080	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32890639	32890639	+	Missense_Mutation	SNP	T	C	C	rs79284655		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:32890639T>C	uc002edh.1	-	5	423	c.247A>G	c.(247-249)AAG>GAG	p.K83E	SLC6A10P_uc002edi.1_RNA					RecName: Full=Transporter;												0						ACCAGCGGCTTGTAGTACACA	0.453													16	158					0	0	0.007413	0	0
SALL1	6299	broad.mit.edu	37	16	51175655	51175655	+	Missense_Mutation	SNP	C	T	T	rs113614842		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:51175655C>T	uc010vgs.1	-	2	509	c.478G>A	c.(478-480)GGC>AGC	p.G160S	SALL1_uc010vgr.1_Missense_Mutation_p.G63S|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	160	Poly-Gly.				adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			ccgccgccgccgctgctgctg	0.463													3	73					0	0	0.004672	0	0
AGRP	181	broad.mit.edu	37	16	67516584	67516584	+	Silent	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:67516584G>A	uc002etg.1	-	4	654	c.354C>T	c.(352-354)TAC>TAT	p.Y118Y	ATP6V0D1_uc002ete.1_5'Flank|ATP6V0D1_uc010vjo.1_5'Flank	NM_001138	NP_001129	O00253	AGRP_HUMAN	agouti related protein homolog isoform 1	118	Agouti.				hormone-mediated signaling pathway|neuropeptide signaling pathway|regulation of feeding behavior	extracellular space|Golgi lumen	neuropeptide hormone activity				0		Acute lymphoblastic leukemia(13;0.00263)|all_hematologic(13;0.0274)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0717)|Epithelial(162;0.16)		GCTTGCGGCAGTAGCAGAAGG	0.597													4	318					0	0	0.000602	0	0
Unknown	0	broad.mit.edu	37	16	70268080	70268080	+	RNA	SNP	T	C	C	rs149244259	by1000genomes	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:70268080T>C	uc010cfp.1	-	3		c.335A>G								Homo sapiens cDNA, FLJ98908.																		GTCTTACTGTTGGCTAAAAGG	0.373													7	24					0	0	0.004482	0	0
Unknown	0	broad.mit.edu	37	16	70268158	70268158	+	RNA	SNP	A	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:70268158A>C	uc010cfp.1	-	3		c.257T>G								Homo sapiens cDNA, FLJ98908.																		TTCTTCATTAAAACAGCTACT	0.333													5	23					0	0	0.000602	0	0
ZFHX3	463	broad.mit.edu	37	16	72821615	72821615	+	Silent	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:72821615G>A	uc002fck.2	-	10	11233	c.10560C>T	c.(10558-10560)GGC>GGT	p.G3520G	uc002fcj.1_RNA|ZFHX3_uc002fcl.2_Silent_p.G2606G	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	3520	Poly-Gly.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				cgccgccgccgccaccgccgc	0.408													7	38					0	0	0.006214	0	0
LOC283922	283922	broad.mit.edu	37	16	74372644	74372644	+	Silent	SNP	A	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:74372644A>G	uc002fcr.2	-	9	1661	c.315T>C	c.(313-315)CCT>CCC	p.P105P	LOC283922_uc010vms.1_RNA					Homo sapiens cDNA FLJ39449 fis, clone PROST2008360, highly similar to Homo sapiens pyruvate dehydrogenase phosphatase regulatory subunit (PDPR), mRNA.												0						TACCCTTGTCAGGGGGAACAA	0.443													4	105					0	0	0.000602	0	0
LOC283922	283922	broad.mit.edu	37	16	74372765	74372765	+	Missense_Mutation	SNP	T	C	C	rs2549261	by1000genomes	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:74372765T>C	uc002fcr.2	-	9	1540	c.194A>G	c.(193-195)CAC>CGC	p.H65R	LOC283922_uc010vms.1_RNA					Homo sapiens cDNA FLJ39449 fis, clone PROST2008360, highly similar to Homo sapiens pyruvate dehydrogenase phosphatase regulatory subunit (PDPR), mRNA.												0						GAAGTCCCAGTGGGGAACCTT	0.502													4	135					0	0	0.009096	0	0
BANP	54971	broad.mit.edu	37	16	88061205	88061205	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:88061205G>A	uc002fkr.2	+	8	1209	c.985G>A	c.(985-987)GTC>ATC	p.V329I	BANP_uc002fkp.2_Missense_Mutation_p.V299I|BANP_uc002fkq.2_Missense_Mutation_p.V299I|BANP_uc010vow.1_Missense_Mutation_p.V337I|BANP_uc002fks.3_Missense_Mutation_p.V298I|BANP_uc002fko.1_Missense_Mutation_p.V235I|BANP_uc010vov.1_Missense_Mutation_p.V304I	NM_079837	NP_524576	Q8N9N5	BANP_HUMAN	BTG3 associated nuclear protein isoform b	330	Necessary and sufficient for TP53 activation (By similarity).|Interaction with CUX1 and HDAC1 (By similarity).				cell cycle|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0				BRCA - Breast invasive adenocarcinoma(80;0.00551)		GAGCCTGGCGGTCAAGAGCTT	0.652													4	249					0	0	0.009096	0	0
ARRB2	409	broad.mit.edu	37	17	4619828	4619828	+	Silent	SNP	A	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:4619828A>C	uc002fyj.2	+	5	510	c.282A>C	c.(280-282)CCA>CCC	p.P94P	ARRB2_uc002fyk.2_Silent_p.P79P|ARRB2_uc002fyl.2_Silent_p.P94P|ARRB2_uc010vsg.1_Silent_p.P94P|ARRB2_uc002fym.2_Silent_p.P79P|ARRB2_uc002fyn.2_5'UTR|ARRB2_uc010ckq.2_5'UTR|ARRB2_uc002fyo.2_5'Flank	NM_004313	NP_004304	P32121	ARRB2_HUMAN	arrestin, beta 2 isoform 1	94					cell chemotaxis|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|G-protein coupled receptor internalization|negative regulation of natural killer cell mediated cytotoxicity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway	coated pit|cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	angiotensin receptor binding|ubiquitin protein ligase binding				0						TGCCCAACCCACCCCGGCCCC	0.667													12	105					0	0	0.006999	0	0
TNK1	8711	broad.mit.edu	37	17	7287071	7287071	+	Missense_Mutation	SNP	C	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:7287071C>A	uc002ggi.3	+	5	630	c.470C>A	c.(469-471)CCG>CAG	p.P157Q	TNK1_uc002ggj.3_Missense_Mutation_p.P157Q|TNK1_uc010cmf.2_RNA|TNK1_uc002ggk.3_5'Flank	NM_003985	NP_003976	Q13470	TNK1_HUMAN	tyrosine kinase, non-receptor, 1	157	Protein kinase.				protein autophosphorylation	membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(122;0.157)				CCCGAAGGCCCGATGGGCACA	0.627													3	53					0.00909568	0.00942444	0.009096	1	0
MFSD6L	162387	broad.mit.edu	37	17	8702100	8702100	+	Silent	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:8702100G>A	uc002glp.1	-	1	487	c.339C>T	c.(337-339)AGC>AGT	p.S113S		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	113						integral to membrane				central_nervous_system(1)	1						TGGTCAGGCCGCTGCTTCCAT	0.632													5	417					0	0	0.001168	0	0
UBB	7314	broad.mit.edu	37	17	16285491	16285491	+	Silent	SNP	C	T	T	rs16962973		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:16285491C>T	uc002gpx.2	+	2	408	c.270C>T	c.(268-270)ACC>ACT	p.T90T	UBB_uc010vwe.1_Intron	NM_018955	NP_061828	P0CG47	UBB_HUMAN	ubiquitin B precursor	90	Ubiquitin-like 2.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		AGACCATCACCCTGGAAGTGG	0.552													5	305					0	0	0.001168	0	0
FLJ36000	284124	broad.mit.edu	37	17	21904155	21904155	+	RNA	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:21904155G>A	uc002gza.2	+	1		c.94G>A				NR_027084				Homo sapiens cDNA FLJ36000 fis, clone TESTI2015180.												0						aaccacaggcggagtccgggg	0													5	615					0	0	0.003080	0	0
LRRC37B2	147172	broad.mit.edu	37	17	28961033	28961033	+	Missense_Mutation	SNP	T	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:28961033T>G	uc002hfl.3	+	5	727	c.496T>G	c.(496-498)TAT>GAT	p.Y166D	LRRC37B2_uc010csj.1_Intron|LRRC37B2_uc010wbq.1_RNA|LRRC37B2_uc010csi.2_RNA					RecName: Full=Putative LRRC37B-like protein 2;												0						AGTTCCAGGATATGACTATAA	0.249													3	153					0	0	0.009096	0	0
MTMR4	9110	broad.mit.edu	37	17	56573137	56573137	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:56573137G>A	uc002iwj.2	-	16	2476	c.2366C>T	c.(2365-2367)ACG>ATG	p.T789M		NM_004687	NP_004678	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	789						cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTGTTGGGGCGTACCTGTAGG	0.527													5	413					0	0	0.000602	0	0
TXNDC2	84203	broad.mit.edu	37	18	9886894	9886894	+	Missense_Mutation	SNP	A	G	G	rs146821851		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr18:9886894A>G	uc002koi.3	+	2	867	c.418A>G	c.(418-420)AAA>GAA	p.K140E	TXNDC2_uc010wzq.1_RNA|TXNDC2_uc002koh.3_Missense_Mutation_p.K73E	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	140	2.|22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2						GTCCTCAGAAAAAGCCATCCA	0.547													5	428					0	0	0.008291	0	0
ALPK2	115701	broad.mit.edu	37	18	56247518	56247518	+	Missense_Mutation	SNP	A	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr18:56247518A>G	uc002lhj.3	-	4	704	c.490T>C	c.(490-492)TCC>CCC	p.S164P		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	164							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						TTGGAGGGGGAGGAGTCAGCT	0.468													4	678					0	0	0.008291	0	0
ZNF57	126295	broad.mit.edu	37	19	2917729	2917729	+	Silent	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:2917729G>A	uc002lwr.2	+	4	1258	c.1110G>A	c.(1108-1110)GGG>GGA	p.G370G	ZNF57_uc010xha.1_Silent_p.G338G	NM_173480	NP_775751	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	370	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		AACAATGTGGGAAAGCCTTCA	0.433													4	278					0	0	0.001168	0	0
ZNF57	126295	broad.mit.edu	37	19	2917733	2917733	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:2917733G>A	uc002lwr.2	+	4	1262	c.1114G>A	c.(1114-1116)GCC>ACC	p.A372T	ZNF57_uc010xha.1_Missense_Mutation_p.A340T	NM_173480	NP_775751	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	372	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		ATGTGGGAAAGCCTTCACTTG	0.443													4	278					0	0	0.000602	0	0
AES	166	broad.mit.edu	37	19	3053928	3053928	+	Silent	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:3053928G>A	uc002lwy.1	-	7	656	c.483C>T	c.(481-483)ACC>ACT	p.T161T	AES_uc002lwx.1_3'UTR|AES_uc002lwz.1_Silent_p.T160T|AES_uc002lxa.1_Silent_p.T105T|AES_uc002lxb.1_Silent_p.T228T|AES_uc002lxc.2_Missense_Mutation_p.R255W	NM_001130	NP_001121	Q08117	AES_HUMAN	amino-terminal enhancer of split isoform b	161	Gly/Pro-rich (GP domain).				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of response to cytokine stimulus|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|response to interleukin-1|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGAGGAGGCCGGTGCCTGCGC	0.687													4	106					0	0	0.009096	0	0
MCOLN1	57192	broad.mit.edu	37	19	7593768	7593768	+	Missense_Mutation	SNP	A	G	G	rs75644222		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:7593768A>G	uc002mgo.2	+	9	1171	c.1046A>G	c.(1045-1047)GAA>GGA	p.E349G	MCOLN1_uc002mgp.2_Missense_Mutation_p.E314G	NM_020533	NP_065394	Q9GZU1	MCLN1_HUMAN	mucolipin 1	349					calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(1)	1						GAGCGGCTGGAATTTGTCAAT	0.622													7	98					0	0	0.008361	0	0
CD209	30835	broad.mit.edu	37	19	7810766	7810767	+	Nonsense_Mutation	DNP	CG	TA	TA	rs146082308		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:7810766_7810767CG>TA	uc002mht.2	-	4	452_453	c.385_386CG>TA	c.(385-387)CGG>TAG	p.R129*	CD209_uc010xju.1_Intron|CD209_uc010dvp.2_Nonsense_Mutation_p.R105*|CD209_uc002mhr.2_Nonsense_Mutation_p.R105*|CD209_uc002mhs.2_Nonsense_Mutation_p.R105*|CD209_uc002mhu.2_Nonsense_Mutation_p.R129*|CD209_uc010dvq.2_Nonsense_Mutation_p.R129*|CD209_uc002mhq.2_Nonsense_Mutation_p.R129*|CD209_uc002mhv.2_Nonsense_Mutation_p.R105*|CD209_uc002mhx.2_Nonsense_Mutation_p.R85*|CD209_uc002mhw.2_Nonsense_Mutation_p.R85*|CD209_uc010dvr.2_Intron	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	129	Extracellular (Probable).|2.|7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						AGCCTTCAGCCGGGTCAGCTCC	0.569													5	598					0	0	0.004672	0	0
MUC16	94025	broad.mit.edu	37	19	9048764	9048764	+	Missense_Mutation	SNP	A	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:9048764A>G	uc002mkp.2	-	5	33071	c.32867T>C	c.(32866-32868)CTT>CCT	p.L10956P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10958	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGTTCACCAAGAGAAAAAGT	0.498													4	337					0	0	0.003080	0	0
MUC16	94025	broad.mit.edu	37	19	9048771	9048771	+	Missense_Mutation	SNP	A	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:9048771A>G	uc002mkp.2	-	5	33064	c.32860T>C	c.(32860-32862)TTT>CTT	p.F10954L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10956	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCAAGAGAAAAAGTCAGAATT	0.483													4	329					0	0	0.003080	0	0
ZNF844	284391	broad.mit.edu	37	19	12187275	12187275	+	Missense_Mutation	SNP	G	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:12187275G>C	uc002mtb.2	+	4	1483	c.1340G>C	c.(1339-1341)CGT>CCT	p.R447P	ZNF844_uc010dym.1_Missense_Mutation_p.R290P	NM_001136501	NP_001129973	Q08AG5	ZN844_HUMAN	zinc finger protein 844	447					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAGAGAAACCGTATGAGTGTA	0.433													6	279					0	0	0.004482	0	0
ZNF844	284391	broad.mit.edu	37	19	12187475	12187475	+	Missense_Mutation	SNP	C	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:12187475C>G	uc002mtb.2	+	4	1683	c.1540C>G	c.(1540-1542)CAT>GAT	p.H514D	ZNF844_uc010dym.1_Missense_Mutation_p.H357D	NM_001136501	NP_001129973	Q08AG5	ZN844_HUMAN	zinc finger protein 844	514					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAAGCCTTCACATCTGCCTCA	0.408													10	202					0	0	0.010729	0	0
ZNF844	284391	broad.mit.edu	37	19	12187502	12187502	+	Missense_Mutation	SNP	A	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:12187502A>G	uc002mtb.2	+	4	1710	c.1567A>G	c.(1567-1569)AAA>GAA	p.K523E	ZNF844_uc010dym.1_Missense_Mutation_p.K366E	NM_001136501	NP_001129973	Q08AG5	ZN844_HUMAN	zinc finger protein 844	523					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CAAATGCATGAAAGGACTCAC	0.413													4	154					0	0	0.009096	0	0
ZNF443	10224	broad.mit.edu	37	19	12542283	12542283	+	Missense_Mutation	SNP	A	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:12542283A>G	uc002mtu.2	-	4	901	c.703T>C	c.(703-705)TCT>CCT	p.S235P		NM_005815	NP_005806	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	235	C2H2-type 4.				induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						CTGTAAAAAGAAAAGGCTTTA	0.378													5	594					0	0	0.013537	0	0
ZNF709	163051	broad.mit.edu	37	19	12575380	12575380	+	Silent	SNP	C	T	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:12575380C>T	uc002mtv.3	-	4	1517	c.1356G>A	c.(1354-1356)CAG>CAA	p.Q452Q	ZNF709_uc002mtw.3_Silent_p.Q420Q|ZNF709_uc002mtx.3_Silent_p.Q452Q	NM_152601	NP_689814	Q8N972	ZN709_HUMAN	zinc finger protein 709 isoform a	452	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTTACCACACTGTTTACATT	0.403													6	558					0	0	0.004990	0	0
ZNF564	163050	broad.mit.edu	37	19	12637723	12637723	+	Missense_Mutation	SNP	C	T	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:12637723C>T	uc002mty.2	-	4	1409	c.1199G>A	c.(1198-1200)AGA>AAA	p.R400K	ZNF709_uc002mtx.3_Intron	NM_144976	NP_659413	Q8TBZ8	ZN564_HUMAN	zinc finger protein 564	400	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GTCAAAGGCTCTACCACATAC	0.433													7	583					0	0	0.006214	0	0
PODNL1	79883	broad.mit.edu	37	19	14043565	14043565	+	Missense_Mutation	SNP	A	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:14043565A>G	uc002mxr.2	-	8	1766	c.1492T>C	c.(1492-1494)TCC>CCC	p.S498P	PODNL1_uc010xni.1_Missense_Mutation_p.S416P|PODNL1_uc010xnj.1_Missense_Mutation_p.S496P|PODNL1_uc002mxs.2_Missense_Mutation_p.S407P	NM_024825	NP_079101	Q6PEZ8	PONL1_HUMAN	podocan-like 1 isoform 1	498						proteinaceous extracellular matrix				central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(19;5.26e-23)			AGGCAGGGGGATGGAGGGGCC	0.572													13	268					0	0	0.014410	0	0
ZNF737	100129842	broad.mit.edu	37	19	20728254	20728254	+	Missense_Mutation	SNP	C	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:20728254C>G	uc002npa.2	-	4	935	c.755G>C	c.(754-756)AGT>ACT	p.S252T		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	252					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TTTCTCTCCACTATGAATTAT	0.403													5	131					0	0	0.001168	0	0
ZNF493	284443	broad.mit.edu	37	19	21606712	21606712	+	Silent	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:21606712T>C	uc002npx.2	+	2	1147	c.867T>C	c.(865-867)TCT>TCC	p.S289S	ZNF493_uc002npw.2_Silent_p.S417S|ZNF493_uc002npy.2_Silent_p.S289S	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	289	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATAAGGAGTCTTCACACCTTA	0.348													4	241					0	0	0.004482	0	0
ZNF429	353088	broad.mit.edu	37	19	21720450	21720450	+	Missense_Mutation	SNP	C	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:21720450C>G	uc002nqd.1	+	4	1732	c.1595C>G	c.(1594-1596)ACT>AGT	p.T532S	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	532					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						AAAATTCATACTGGAGAGAAA	0.363													3	220					0	0	0.001984	0	0
ZNF208	7757	broad.mit.edu	37	19	22156530	22156530	+	Missense_Mutation	SNP	A	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:22156530A>G	uc002nqp.2	-	4	1455	c.1306T>C	c.(1306-1308)TGG>CGG	p.W436R	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTTGAGGACCAGTTGAAAGCT	0.388													4	289					0	0	0.009096	0	0
ZNF780A	284323	broad.mit.edu	37	19	40580552	40580552	+	Missense_Mutation	SNP	T	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:40580552T>G	uc002omy.2	-	6	2022	c.1797A>C	c.(1795-1797)CAA>CAC	p.Q599H	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Missense_Mutation_p.Q599H|ZNF780A_uc010xvh.1_Missense_Mutation_p.Q600H	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	599	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					GTCGAATAAGTTGCATATGAA	0.403													8	509					0	0	0.008291	0	0
PRX	57716	broad.mit.edu	37	19	40902612	40902612	+	Silent	SNP	C	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:40902612C>G	uc002onr.2	-	7	1916	c.1647G>C	c.(1645-1647)CCG>CCC	p.P549P	PRX_uc002onq.2_Silent_p.P410P|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	549	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].|18.				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding	p.P549P(1)		ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTGACACTTTCGGCAGCTGTA	0.577													4	680					0	0	0.001168	0	0
PRX	57716	broad.mit.edu	37	19	40902620	40902620	+	Missense_Mutation	SNP	G	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:40902620G>C	uc002onr.2	-	7	1908	c.1639C>G	c.(1639-1641)CAG>GAG	p.Q547E	PRX_uc002onq.2_Missense_Mutation_p.Q408E|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	547	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].|18.				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TTCGGCAGCTGTACCTCTGGA	0.587													4	676					0	0	0.001168	0	0
CRX	1406	broad.mit.edu	37	19	48342846	48342846	+	Silent	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:48342846G>A	uc002phq.3	+	4	726	c.522G>A	c.(520-522)GCG>GCA	p.A174A		NM_000554	NP_000545	O43186	CRX_HUMAN	cone-rod homeobox protein	174					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		TGCCTGAGGCGCAGCGGGCTG	0.697													4	167					0	0	0.009096	0	0
CD37	951	broad.mit.edu	37	19	49842036	49842036	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:49842036G>A	uc002pnd.2	+	6	648	c.527G>A	c.(526-528)CGC>CAC	p.R176H	uc002pnb.1_Intron|CD37_uc002pnc.2_RNA|CD37_uc010yam.1_Missense_Mutation_p.R176H|CD37_uc010yan.1_Missense_Mutation_p.R108H|CD37_uc002pnf.3_Missense_Mutation_p.R148H|CD37_uc002pne.2_Missense_Mutation_p.R108H	NM_001774	NP_001765	P11049	CD37_HUMAN	CD37 antigen isoform A	176	Extracellular (Potential).					integral to membrane					0		all_lung(116;2.81e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00088)|GBM - Glioblastoma multiforme(486;0.0443)		GAGGCGCACCGCGTGCCCTGC	0.622													4	366					0	0	0.009096	0	0
ALDH16A1	126133	broad.mit.edu	37	19	49971679	49971679	+	Silent	SNP	G	A	A	rs144577268		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:49971679G>A	uc002pnt.2	+	15	2096	c.1980G>A	c.(1978-1980)CCG>CCA	p.P660P	ALDH16A1_uc010yar.1_Silent_p.P609P|ALDH16A1_uc010yas.1_Silent_p.P495P|ALDH16A1_uc010yat.1_Silent_p.P497P	NM_153329	NP_699160	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	660							oxidoreductase activity|protein binding			skin(1)	1		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		TGCGGGAGCCGCTGGGTGTGC	0.627													4	393					0	0	0.009096	0	0
ZNF83	55769	broad.mit.edu	37	19	53116885	53116885	+	Silent	SNP	A	G	G	rs7247257		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:53116885A>G	uc002pzu.3	-	2	2177	c.933T>C	c.(931-933)CAT>CAC	p.H311H	ZNF83_uc002pzv.3_Silent_p.H311H|ZNF83_uc010eps.2_Silent_p.H283H|ZNF83_uc010ept.2_Silent_p.H311H|ZNF83_uc010epu.2_Silent_p.H311H|ZNF83_uc010epv.2_Silent_p.H311H|ZNF83_uc010epw.2_Silent_p.H311H|ZNF83_uc010epx.2_Silent_p.H283H|ZNF83_uc010epy.2_Silent_p.H311H|ZNF83_uc010epz.2_Silent_p.H283H	NM_018300	NP_060770	P51522	ZNF83_HUMAN	zinc finger protein 83 isoform a	311	C2H2-type 8.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		TCTCTCCAGTATGAATTCTCC	0.418													7	612					0	0	0.003080	0	0
ZNF816A	125893	broad.mit.edu	37	19	53453890	53453890	+	Missense_Mutation	SNP	G	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:53453890G>C	uc002qal.1	-	5	1439	c.1138C>G	c.(1138-1140)CAG>GAG	p.Q380E	ZNF321_uc010eqj.2_Intron|ZNF321_uc002qak.1_Intron|ZNF816A_uc002qam.1_Missense_Mutation_p.Q364E	NM_001031665	NP_001026835	Q0VGE8	ZN816_HUMAN	zinc finger protein 816A	380	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0313)		GATGATTTCTGACTGAAGGTC	0.398													6	691					0	0	0.006214	0	0
ZNF845	91664	broad.mit.edu	37	19	53855364	53855364	+	Missense_Mutation	SNP	C	T	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:53855364C>T	uc010ydv.1	+	4	1553	c.1436C>T	c.(1435-1437)ACA>ATA	p.T479I	ZNF845_uc010ydw.1_Missense_Mutation_p.T479I	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	479	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCAGTCAGACATCATCCCTT	0.378													9	377					0	0	0.003163	0	0
ADAM17	6868	broad.mit.edu	37	2	9661363	9661363	+	Missense_Mutation	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:9661363T>C	uc002qzu.2	-	8	1109	c.926A>G	c.(925-927)AAG>AGG	p.K309R	ADAM17_uc010ewy.2_Missense_Mutation_p.K309R|ADAM17_uc010ewz.2_Intron	NM_003183	NP_003174	P78536	ADA17_HUMAN	a disintegrin and metalloprotease domain 17	309	Peptidase M12B.|Extracellular (Potential).				B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			lung(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		CCAAGCATCCTTTTCTTCATT	0.393													3	373					0	0	0.001168	0	0
PNPT1	87178	broad.mit.edu	37	2	55913551	55913551	+	Missense_Mutation	SNP	G	A	A	rs145552327		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:55913551G>A	uc002rzf.2	-	3	304	c.251C>T	c.(250-252)GCG>GTG	p.A84V	PNPT1_uc002rzg.2_RNA	NM_033109	NP_149100	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	84					mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TTTACTGACCGCTGTGACCAT	0.378													4	212					0	0	0.001168	0	0
TGOLN2	10618	broad.mit.edu	37	2	85554607	85554607	+	Missense_Mutation	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:85554607T>C	uc010fgd.1	-	2	537	c.248A>G	c.(247-249)AAG>AGG	p.K83R	TGOLN2_uc002soz.2_Missense_Mutation_p.K83R|TGOLN2_uc002spa.2_Intron|TGOLN2_uc002spb.2_Missense_Mutation_p.K83R|TGOLN2_uc002spc.1_Missense_Mutation_p.K83R	NM_006464	NP_006455	O43493	TGON2_HUMAN	trans-golgi network protein 2	83	Extracellular (Potential).|14 X 14 AA tandem repeats.|3.					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding				0						CGCACCCGACTTGTTGGGGGT	0.602													5	806					0	0	0.006214	0	0
TGOLN2	10618	broad.mit.edu	37	2	85554616	85554616	+	Missense_Mutation	SNP	G	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:85554616G>C	uc010fgd.1	-	2	528	c.239C>G	c.(238-240)ACC>AGC	p.T80S	TGOLN2_uc002soz.2_Missense_Mutation_p.T80S|TGOLN2_uc002spa.2_Intron|TGOLN2_uc002spb.2_Missense_Mutation_p.T80S|TGOLN2_uc002spc.1_Missense_Mutation_p.T80S	NM_006464	NP_006455	O43493	TGON2_HUMAN	trans-golgi network protein 2	80	Extracellular (Potential).|14 X 14 AA tandem repeats.|2.					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding				0						CTTGTTGGGGGTGTCTTCTGG	0.597													5	748					0	0	0.002450	0	0
IMMT	10989	broad.mit.edu	37	2	86393641	86393641	+	Missense_Mutation	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:86393641T>C	uc002sqz.3	-	7	1170	c.782A>G	c.(781-783)GAC>GGC	p.D261G	IMMT_uc002sqy.3_Missense_Mutation_p.D2G|IMMT_uc002srb.3_Missense_Mutation_p.D250G|IMMT_uc002sra.3_Missense_Mutation_p.D260G|IMMT_uc010ytd.1_Missense_Mutation_p.D249G|IMMT_uc010yte.1_Missense_Mutation_p.D214G|IMMT_uc002src.1_Missense_Mutation_p.D2G|IMMT_uc002srd.2_Missense_Mutation_p.D261G|IMMT_uc002sre.3_Missense_Mutation_p.D249G|IMMT_uc010ytf.1_Missense_Mutation_p.D183G|IMMT_uc010fgs.1_Missense_Mutation_p.D258G	NM_006839	NP_006830	Q16891	IMMT_HUMAN	inner membrane protein, mitochondrial isoform 1	261	Mitochondrial intermembrane (Potential).					integral to mitochondrial inner membrane	protein binding			skin(1)	1						CTCAGAATTGTCCATGGCGGC	0.463													3	215					0	0	0.009096	0	0
POTEF	728378	broad.mit.edu	37	2	130877802	130877802	+	Missense_Mutation	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:130877802T>C	uc010fmh.2	-	3	687	c.287A>G	c.(286-288)AAC>AGC	p.N96S		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	96						cell cortex	ATP binding			skin(3)|ovary(2)	5						GCCCATCTTGTTCCTGAGTGT	0.607													4	595					0	0	0.006214	0	0
GTF3C3	9330	broad.mit.edu	37	2	197657782	197657782	+	Silent	SNP	C	T	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:197657782C>T	uc002uts.2	-	3	399	c.309G>A	c.(307-309)GAG>GAA	p.E103E	GTF3C3_uc010zgu.1_Silent_p.E103E|GTF3C3_uc002utu.2_Silent_p.E103E	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	103	Glu-rich.					transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7						cctcctcctcctcttcttcct	0.343													6	161					0	0	0.006214	0	0
MYH7B	57644	broad.mit.edu	37	20	33574742	33574742	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr20:33574742G>A	uc002xbi.1	+	13	1176	c.1084G>A	c.(1084-1086)GTC>ATC	p.V362I		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	320	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			CAGCCAGGGCGTCATCACCGT	0.592													4	307					0	0	0.001984	0	0
SEMG2	6407	broad.mit.edu	37	20	43851398	43851398	+	Silent	SNP	G	T	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr20:43851398G>T	uc010ggz.2	+	2	1182	c.1125G>T	c.(1123-1125)TCG>TCT	p.S375S	SEMG2_uc002xnk.2_Silent_p.S375S|SEMG2_uc002xnl.2_Silent_p.S375S	NM_003008	NP_002999	Q02383	SEMG2_HUMAN	semenogelin II precursor	375	Repeat-rich region.|4 X 60 AA tandem repeats, type I.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)				GCAGTATTTCGATCCAAACTG	0.373													6	345					2.17888e-05	2.29918e-05	0.006214	1	0
SEMG2	6407	broad.mit.edu	37	20	43851414	43851414	+	Missense_Mutation	SNP	C	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr20:43851414C>A	uc010ggz.2	+	2	1198	c.1141C>A	c.(1141-1143)CAA>AAA	p.Q381K	SEMG2_uc002xnk.2_Missense_Mutation_p.Q381K|SEMG2_uc002xnl.2_Missense_Mutation_p.Q381K	NM_003008	NP_002999	Q02383	SEMG2_HUMAN	semenogelin II precursor	381	Repeat-rich region.|4 X 60 AA tandem repeats, type I.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)				AACTGAAGAGCAAATACATGG	0.388													7	345					3.86212e-05	4.05052e-05	0.008291	1	0
SON	6651	broad.mit.edu	37	21	34923961	34923961	+	Silent	SNP	C	T	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr21:34923961C>T	uc002yse.1	+	3	2473	c.2424C>T	c.(2422-2424)ACC>ACT	p.T808T	SON_uc002ysb.1_Silent_p.T808T|SON_uc002ysc.2_Silent_p.T808T|SON_uc002ysd.2_Intron|SON_uc002ysf.1_Intron|SON_uc002ysg.2_5'Flank	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	808	17 X 10 AA tandem repeats of L-A-[ST]- [NSG]-[TS]-MDSQM.				anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						TGTTAGCAACCAGCTCCATGG	0.512													5	689					0	0	0.010729	0	0
SON	6651	broad.mit.edu	37	21	34923991	34923991	+	Silent	SNP	C	T	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr21:34923991C>T	uc002yse.1	+	3	2503	c.2454C>T	c.(2452-2454)ACC>ACT	p.T818T	SON_uc002ysb.1_Silent_p.T818T|SON_uc002ysc.2_Silent_p.T818T|SON_uc002ysd.2_Intron|SON_uc002ysf.1_Intron|SON_uc002ysg.2_5'Flank	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	818	17 X 10 AA tandem repeats of L-A-[ST]- [NSG]-[TS]-MDSQM.				anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						TGTTAGCAACCAGCTCCATGG	0.507													6	674					0	0	0.006122	0	0
PCNT	5116	broad.mit.edu	37	21	47754527	47754527	+	Missense_Mutation	SNP	A	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr21:47754527A>G	uc002zji.3	+	3	591	c.484A>G	c.(484-486)AGT>GGT	p.S162G	PCNT_uc002zjj.2_Missense_Mutation_p.S44G|PCNT_uc010gqk.1_RNA	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	162					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GTTCACAGTCAGTGACCACCC	0.552													4	254					0	0	0.000602	0	0
MICAL3	57553	broad.mit.edu	37	22	18387568	18387568	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr22:18387568G>A	uc002zng.3	-	3	655	c.302C>T	c.(301-303)ACA>ATA	p.T101I	MICAL3_uc011agl.1_Missense_Mutation_p.T101I|MICAL3_uc002znh.2_Missense_Mutation_p.T101I|MICAL3_uc002znj.1_5'Flank|MICAL3_uc002znk.1_Missense_Mutation_p.T101I|MICAL3_uc002znl.1_5'UTR|MICAL3_uc010grf.2_Missense_Mutation_p.T101I|MICAL3_uc011agm.1_Missense_Mutation_p.T101I	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	101	FAD (Potential).					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		GTCGATGGCTGTACGGAGACC	0.512													5	161					0	0	0.000602	0	0
MCM5	4174	broad.mit.edu	37	22	35796511	35796511	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr22:35796511G>A	uc003anu.3	+	2	174	c.80G>A	c.(79-81)CGC>CAC	p.R27H	MCM5_uc010gwr.2_5'UTR|MCM5_uc003anv.3_Missense_Mutation_p.R27H	NM_006739	NP_006730	P33992	MCM5_HUMAN	minichromosome maintenance complex component 5	27					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)	1						GGGCAGGCCCGCAAATCGCAG	0.647													4	187					0	0	0.009096	0	0
MKL1	57591	broad.mit.edu	37	22	40820376	40820376	+	Missense_Mutation	SNP	A	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr22:40820376A>C	uc003ayv.1	-	5	518	c.311T>G	c.(310-312)GTG>GGG	p.V104G	MKL1_uc003ayw.1_Missense_Mutation_p.V104G|MKL1_uc010gye.1_Missense_Mutation_p.V104G|MKL1_uc010gyf.1_Missense_Mutation_p.V104G	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	104	Mediates interaction with SCAI and ACTB (By similarity).				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GGGATAGTTCACCTGGCCCAC	0.592			T	RBM15	acute megakaryocytic leukemia								4	114					0	0	0.001168	0	0
ZNF619	285267	broad.mit.edu	37	3	40529386	40529386	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:40529386G>A	uc011azb.1	+	6	1783	c.1505G>A	c.(1504-1506)GGG>GAG	p.G502E	ZNF619_uc010hhz.2_Missense_Mutation_p.G453E|ZNF619_uc003ckj.2_Missense_Mutation_p.G446E|ZNF619_uc011azc.1_Missense_Mutation_p.G462E|ZNF619_uc011azd.1_Missense_Mutation_p.G418E|ZNF619_uc011aza.1_Missense_Mutation_p.G404E	NM_001145082	NP_001138554	E9PCD9	E9PCD9_HUMAN	zinc finger protein 619 isoform 1	502					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		AAGGAGTGCGGGAAAGCCTTC	0.473													4	222					0	0	0.000602	0	0
MAP4	4134	broad.mit.edu	37	3	47958222	47958222	+	Silent	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:47958222G>A	uc003csb.2	-	7	1621	c.1095C>T	c.(1093-1095)GCC>GCT	p.A365A	MAP4_uc003csc.3_Silent_p.A365A|MAP4_uc011bbf.1_Silent_p.A342A|MAP4_uc003csf.3_Silent_p.A382A	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	365	26 residues 1.|17 X 14 AA tandem repeats.				negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		CCTTGGAAGGGGCTAAGTCCA	0.478													4	665					0	0	0.001984	0	0
MAP4	4134	broad.mit.edu	37	3	47958225	47958225	+	Silent	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:47958225T>C	uc003csb.2	-	7	1618	c.1092A>G	c.(1090-1092)TTA>TTG	p.L364L	MAP4_uc003csc.3_Silent_p.L364L|MAP4_uc011bbf.1_Silent_p.L341L|MAP4_uc003csf.3_Silent_p.L381L	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	364	26 residues 1.|17 X 14 AA tandem repeats.				negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		TGGAAGGGGCTAAGTCCATTT	0.478													4	660					0	0	0.001984	0	0
HEG1	57493	broad.mit.edu	37	3	124728565	124728565	+	Silent	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:124728565T>C	uc003ehs.3	-	8	3245	c.3177A>G	c.(3175-3177)AAA>AAG	p.K1059K	HEG1_uc011bke.1_Silent_p.K1159K	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	1059	Extracellular (Potential).|EGF-like 2; calcium-binding (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						TGCATATCCCTTTTTCCAACT	0.418													3	101					0	0	0.004672	0	0
CP	1356	broad.mit.edu	37	3	148895648	148895648	+	Silent	SNP	G	A	A	rs147475926	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:148895648G>A	uc003ewy.3	-	17	3250	c.2997C>T	c.(2995-2997)CAC>CAT	p.H999H	CP_uc011bnr.1_RNA|CP_uc003eww.3_Silent_p.H151H|CP_uc003ewx.3_Silent_p.H780H|CP_uc003ewz.2_Silent_p.H999H	NM_000096	NP_000087	P00450	CERU_HUMAN	ceruloplasmin precursor	999	F5/8 type A 3.|Plastocyanin-like 6.	Copper 3; type 3.			cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	AGCTATGGCCGTGAAAATGTA	0.393													4	442					0	0	0.000602	0	0
ZNF732	654254	broad.mit.edu	37	4	265333	265333	+	Missense_Mutation	SNP	A	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:265333A>G	uc011buu.1	-	3	1324	c.1310T>C	c.(1309-1311)ATA>ACA	p.I437T	ZNF732_uc010ibb.1_Intron	NM_001137608	NP_001131080	B4DXR9	ZN732_HUMAN	zinc finger protein 732	438	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGTATGAATTATCTTATGTTT	0.403													3	118					0	0	0.004672	0	0
BMP2K	55589	broad.mit.edu	37	4	79792142	79792142	+	Silent	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:79792142G>A	uc003hlk.2	+	11	1603	c.1437G>A	c.(1435-1437)CAG>CAA	p.Q479Q	BMP2K_uc010ijl.1_RNA|BMP2K_uc003hlj.2_Silent_p.Q479Q|BMP2K_uc003hll.2_5'Flank	NM_198892	NP_942595	Q9NSY1	BMP2K_HUMAN	BMP-2 inducible kinase isoform a	479	Gln/His-rich.			Missing (in Ref. 2; CAB70863).		nucleus	ATP binding|protein serine/threonine kinase activity			lung(1)	1						agcaacagcagcagcagcagc	0.174													3	76					0	0	0.004672	0	0
KIAA1109	84162	broad.mit.edu	37	4	123274248	123274248	+	Missense_Mutation	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:123274248T>C	uc003ieh.2	+	79	14084	c.14039T>C	c.(14038-14040)CTT>CCT	p.L4680P	KIAA1109_uc003iem.2_Missense_Mutation_p.L1036P	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	4680					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TCTTGGGCCCTTTTTCATTTA	0.373													3	205					0	0	0.004672	0	0
OTUD4	54726	broad.mit.edu	37	4	146058891	146058891	+	Silent	SNP	A	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:146058891A>C	uc003ika.3	-	21	2979	c.2841T>G	c.(2839-2841)GTT>GTG	p.V947V	OTUD4_uc003ijz.3_Silent_p.V946V	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	1011							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					CTCTGCTATCAACAGAGTTGG	0.388													4	538					0	0	0.009096	0	0
OTUD4	54726	broad.mit.edu	37	4	146058966	146058966	+	Silent	SNP	G	A	A	rs146975610	by1000genomes	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:146058966G>A	uc003ika.3	-	21	2904	c.2766C>T	c.(2764-2766)AGC>AGT	p.S922S	OTUD4_uc003ijz.3_Silent_p.S921S	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	986							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					TTTCTTTCAGGCTTTGAATGG	0.453													5	589					0	0	0.003080	0	0
OTUD4	54726	broad.mit.edu	37	4	146059006	146059006	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:146059006G>A	uc003ika.3	-	21	2864	c.2726C>T	c.(2725-2727)ACT>ATT	p.T909I	OTUD4_uc003ijz.3_Missense_Mutation_p.T908I	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	973							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					AACAGGCACAGTTTCTCTCTC	0.463													10	579					0	0	0.002450	0	0
OTUD4	54726	broad.mit.edu	37	4	146059041	146059041	+	Silent	SNP	A	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:146059041A>G	uc003ika.3	-	21	2829	c.2691T>C	c.(2689-2691)CAT>CAC	p.H897H	OTUD4_uc003ijz.3_Silent_p.H896H	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	961							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					GAGTGGGAGGATGAGCCTTTC	0.478													7	529					0	0	0.004482	0	0
SPZ1	84654	broad.mit.edu	37	5	79616605	79616605	+	Missense_Mutation	SNP	C	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr5:79616605C>G	uc003kgn.2	+	1	816	c.571C>G	c.(571-573)CAG>GAG	p.Q191E	uc011ctk.1_RNA	NM_032567	NP_115956	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	191	Basic motif (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(1)	1		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		AAAGAAACAGCAGATGATAAT	0.353													9	285					0	0	0.004482	0	0
XRCC4	7518	broad.mit.edu	37	5	82406896	82406896	+	Silent	SNP	A	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr5:82406896A>G	uc003kib.2	+	3	317	c.189A>G	c.(187-189)AAA>AAG	p.K63K	XRCC4_uc003kia.1_Silent_p.K63K|XRCC4_uc003kid.2_Silent_p.K63K|XRCC4_uc003kic.2_Silent_p.K63K|XRCC4_uc003kie.2_Silent_p.K63K|XRCC4_uc003kif.1_Silent_p.K63K	NM_022406	NP_071801	Q13426	XRCC4_HUMAN	X-ray repair cross complementing protein 4	63					DNA ligation involved in DNA repair|double-strand break repair via nonhomologous end joining|initiation of viral infection|positive regulation of ligase activity|provirus integration|response to X-ray	cytosol|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|nucleoplasm	DNA binding|protein C-terminus binding			skin(3)	3		Lung NSC(167;0.00132)|all_lung(232;0.00154)|Ovarian(174;0.034)		OV - Ovarian serous cystadenocarcinoma(54;1.44e-38)|Epithelial(54;3.72e-33)|all cancers(79;9.22e-28)		CAATGGAAAAAGGGAAATATG	0.338								NHEJ					3	137					0	0	0.009096	0	0
HIST1H2BJ	8970	broad.mit.edu	37	6	27100492	27100492	+	Missense_Mutation	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:27100492T>C	uc003niv.2	-	1	84	c.38A>G	c.(37-39)AAG>AGG	p.K13R	HIST1H2BJ_uc003niu.1_RNA|HIST1H2AG_uc003niw.2_5'Flank	NM_021058	NP_066402	P06899	H2B1J_HUMAN	histone cluster 1, H2bj	13					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0						CTTGGAGCCCTTTTTCGGGGC	0.537													3	280					0	0	0.004672	0	0
DAXX	1616	broad.mit.edu	37	6	33287891	33287891	+	Silent	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:33287891T>C	uc003oec.2	-	5	1566	c.1362A>G	c.(1360-1362)GAA>GAG	p.E454E	ZBTB22_uc003oeb.2_5'Flank|ZBTB22_uc010juu.2_5'Flank|DAXX_uc011drd.1_Silent_p.E379E|DAXX_uc011dre.1_Silent_p.E466E|DAXX_uc003oed.2_Silent_p.E454E	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	454	Asp/Glu-rich (acidic).|Potential.|Necessary for interaction with USP7.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			pancreas(18)|ovary(2)|skin(2)|prostate(1)	23						cctcctcctcttcttcttcct	0.244			Mis|F|N		Pancreatic neuroendocrine tumors								4	98					0	0	0.009096	0	0
DAXX	1616	broad.mit.edu	37	6	33287900	33287900	+	Silent	SNP	C	T	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:33287900C>T	uc003oec.2	-	5	1557	c.1353G>A	c.(1351-1353)GAG>GAA	p.E451E	ZBTB22_uc003oeb.2_5'Flank|ZBTB22_uc010juu.2_5'Flank|DAXX_uc011drd.1_Silent_p.E376E|DAXX_uc011dre.1_Silent_p.E463E|DAXX_uc003oed.2_Silent_p.E451E	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	451	Asp/Glu-rich (acidic).|Potential.|Necessary for interaction with USP7.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			pancreas(18)|ovary(2)|skin(2)|prostate(1)	23						cttcttcttcctcctcctcct	0.254			Mis|F|N		Pancreatic neuroendocrine tumors								5	114					0	0	0.000602	0	0
PTK7	5754	broad.mit.edu	37	6	43109789	43109789	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:43109789G>A	uc003oub.1	+	12	2087	c.1889G>A	c.(1888-1890)CGC>CAC	p.R630H	PTK7_uc003ouc.1_Intron|PTK7_uc003oud.1_Missense_Mutation_p.R590H|PTK7_uc003oue.1_Missense_Mutation_p.R500H|PTK7_uc003ouf.1_RNA|PTK7_uc003oug.1_RNA|PTK7_uc011dve.1_Missense_Mutation_p.R638H|PTK7_uc010jyj.1_Intron	NM_002821	NP_002812	Q13308	PTK7_HUMAN	PTK7 protein tyrosine kinase 7 isoform a	630	Ig-like C2-type 7.|Extracellular (Potential).				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			ovary(2)|large_intestine(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GGCAAGGACCGCATCCTGGAC	0.667													4	167					0	0	0.009096	0	0
BVES	11149	broad.mit.edu	37	6	105573335	105573335	+	Missense_Mutation	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:105573335T>C	uc003pqw.2	-	4	627	c.470A>G	c.(469-471)AAG>AGG	p.K157R	BVES_uc003pqx.2_Missense_Mutation_p.K157R|BVES_uc003pqy.2_Missense_Mutation_p.K157R	NM_147147	NP_671488	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance isoform 5	157	Cytoplasmic (Potential).				epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity				0		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				AGTTTGGCCCTTTTTCAAGGT	0.438													5	633					0	0	0.000602	0	0
REPS1	85021	broad.mit.edu	37	6	139266690	139266690	+	Missense_Mutation	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:139266690T>C	uc003qii.2	-	3	1001	c.422A>G	c.(421-423)AAG>AGG	p.K141R	REPS1_uc003qig.3_Missense_Mutation_p.K141R|REPS1_uc011edr.1_Missense_Mutation_p.K141R|REPS1_uc003qij.2_Missense_Mutation_p.K141R|REPS1_uc003qik.2_5'UTR	NM_031922	NP_114128	Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	141						coated pit|plasma membrane	calcium ion binding|SH3 domain binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)		TACGGATCCCTTTTTCACTTG	0.478													5	668					0	0	0.000602	0	0
FAM120B	84498	broad.mit.edu	37	6	170627725	170627725	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:170627725G>A	uc003qxp.2	+	2	1355	c.1247G>A	c.(1246-1248)TGT>TAT	p.C416Y	FAM120B_uc003qxo.1_Missense_Mutation_p.C416Y|FAM120B_uc011ehd.1_Intron	NM_032448	NP_115824	Q96EK7	F120B_HUMAN	family with sequence similarity 120B	416					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1		Breast(66;0.000338)|Esophageal squamous(34;0.241)		OV - Ovarian serous cystadenocarcinoma(33;3.94e-22)|BRCA - Breast invasive adenocarcinoma(81;6.47e-06)|GBM - Glioblastoma multiforme(31;0.0899)		GTTCCCATGTGTACAGGCCCT	0.522													6	838					0	0	0.008291	0	0
ZNF735	730291	broad.mit.edu	37	7	63680322	63680322	+	Missense_Mutation	SNP	A	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:63680322A>C	uc011kdn.1	+	4	893	c.893A>C	c.(892-894)AAA>ACA	p.K298T		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	298	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGACCCTACAAATGTGAAGAA	0.458													3	253					0	0	0.004672	0	0
SPDYE5	442590	broad.mit.edu	37	7	75130895	75130895	+	Missense_Mutation	SNP	C	T	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:75130895C>T	uc011kfy.1	+	6	906	c.770C>T	c.(769-771)CCG>CTG	p.P257L		NM_001099435	NP_001092905	A6NIY4	SPDE5_HUMAN	speedy homolog E5	257	Arg-rich.										0						TCCATGAACCCGAGGGCCAGG	0.592													6	628					0	0	0.003163	0	0
MUC17	140453	broad.mit.edu	37	7	100676600	100676600	+	Missense_Mutation	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:100676600T>C	uc003uxp.1	+	3	1956	c.1903T>C	c.(1903-1905)TCT>CCT	p.S635P	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	635	Extracellular (Potential).|8.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AACAAGTATGTCTGTCAGCAC	0.478													4	879					0	0	0.001168	0	0
SSPO	23145	broad.mit.edu	37	7	149520450	149520450	+	Missense_Mutation	SNP	G	A	A	rs143666617	by1000genomes	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:149520450G>A	uc010lpk.2	+	93	13268	c.13268G>A	c.(13267-13269)TGC>TAC	p.C4423Y	SSPO_uc010lpm.1_RNA|SSPO_uc003wgg.2_Intron|SSPO_uc003wgh.2_RNA|SSPO_uc003wgi.1_Intron	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	4423					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GAGGACAGCTGCACGCCTCCC	0.647													5	446					0	0	0.001984	0	0
TATDN1	83940	broad.mit.edu	37	8	125520718	125520718	+	Silent	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:125520718T>C	uc003yrd.2	-	8	555	c.513A>G	c.(511-513)GGA>GGG	p.G171G	TATDN1_uc003yre.2_RNA|TATDN1_uc010mdm.2_Silent_p.G124G|TATDN1_uc003yrf.2_Silent_p.G171G	NM_032026	NP_114415	Q6P1N9	TATD1_HUMAN	TatD DNase domain containing 1 isoform a	171						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding				0	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			TACTTACCACTCCCCCTACAC	0.184													3	221					0	0	0.000602	0	0
VPS28	51160	broad.mit.edu	37	8	145649475	145649475	+	Missense_Mutation	SNP	C	T	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:145649475C>T	uc003zcr.1	-	8	550	c.497G>A	c.(496-498)CGC>CAC	p.R166H	VPS28_uc003zcs.1_Missense_Mutation_p.R166H|VPS28_uc003zct.1_Missense_Mutation_p.R166H	NM_016208	NP_057292	Q9UK41	VPS28_HUMAN	vacuolar protein sorting 28 isoform 1	166	VPS28 C-terminal.				cellular membrane organization|endosome transport|negative regulation of protein ubiquitination|protein transport	cytosol|late endosome membrane|plasma membrane	protein binding				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			GTGGCTCATGCGGTGCATGGT	0.692													4	272					0	0	0.009096	0	0
OR13C9	286362	broad.mit.edu	37	9	107379676	107379676	+	Silent	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:107379676T>C	uc011lvr.1	-	1	810	c.810A>G	c.(808-810)TCA>TCG	p.S270S		NM_001001956	NP_001001956	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C,	270	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCAAGTCATCTGAATTAAGTG	0.403													4	339					0	0	0.006122	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070695	141070695	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:141070695G>A	uc004com.2	+	4	359	c.98G>A	c.(97-99)CGC>CAC	p.R33H	TUBBP5_uc010ncq.2_Silent_p.T210T					RecName: Full=Putative tubulin beta-4q chain;												0						GCCAAGGGACGCTACACCGAA	0.592													4	17					0	0	0.000602	0	0
ASB11	140456	broad.mit.edu	37	X	15307688	15307688	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chrX:15307688G>A	uc004cwp.1	-	5	593	c.593C>T	c.(592-594)ACT>ATT	p.T198I	ASB11_uc004cwo.1_Missense_Mutation_p.T177I|ASB11_uc010nes.1_RNA|ASB11_uc010net.1_Missense_Mutation_p.T181I	NM_080873	NP_543149	Q8WXH4	ASB11_HUMAN	ankyrin repeat and SOCS box-containing protein	198	ANK 5.				intracellular signal transduction					breast(2)|skin(1)	3	Hepatocellular(33;0.183)					ATATAGGGGAGTTCCGAGCTG	0.438													4	433					0	0	0.000602	0	0
ATRX	546	broad.mit.edu	37	X	76855029	76855029	+	Missense_Mutation	SNP	T	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chrX:76855029T>C	uc004ecp.3	-	25	6039	c.5807A>G	c.(5806-5808)AAG>AGG	p.K1936R	ATRX_uc004ecq.3_Missense_Mutation_p.K1898R|ATRX_uc004eco.3_Missense_Mutation_p.K1721R	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1936	Poly-Lys.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTTTTTCCCCTTTTTCCCTTT	0.318			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						4	565					0	0	0.009096	0	0
PSMD10	5716	broad.mit.edu	37	X	107331078	107331078	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chrX:107331078G>A	uc004enp.1	-	4	463	c.365C>T	c.(364-366)GCT>GTT	p.A122V	PSMD10_uc004enq.1_Missense_Mutation_p.A122V|PSMD10_uc010nph.1_Missense_Mutation_p.A73V	NM_002814	NP_002805	O75832	PSD10_HUMAN	proteasome 26S non-ATPase subunit 10 isoform 1	122	ANK 4.|Interaction with RELA.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cytoplasmic sequestering of NF-kappaB|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of MAPKKK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of release of cytochrome c from mitochondria|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|proteasome regulatory particle assembly|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus|proteasome regulatory particle	transcription factor binding			ovary(1)	1						TAACATGACAGCGATCTGGAA	0.448													4	266					0	0	0.009096	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994960	140994960	+	Silent	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chrX:140994960G>A	uc004fbt.2	+	4	2056	c.1770G>A	c.(1768-1770)CTG>CTA	p.L590L	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	590							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGGACTCCCTGTCTCCTCACT	0.567										HNSCC(15;0.026)			5	798					0	0	0.004482	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795255	142795255	+	Silent	SNP	C	T	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chrX:142795255C>T	uc004fbz.2	-	2	1177	c.423G>A	c.(421-423)CTG>CTA	p.L141L		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	141										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					CAGATGAGTCCAGGTCTTCGT	0.517													5	459					0	0	0.008291	0	0
HMGB3	3149	broad.mit.edu	37	X	150156360	150156360	+	Silent	SNP	G	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chrX:150156360G>A	uc004fep.2	+	5	668	c.576G>A	c.(574-576)GAG>GAA	p.E192E	HMGB3_uc004feq.2_3'UTR|HMGB3_uc004fer.2_Silent_p.E192E	NM_005342	NP_005333	O15347	HMGB3_HUMAN	high-mobility group box 3	192	Asp/Glu-rich (acidic).				DNA recombination|multicellular organismal development	chromosome|nucleus	DNA bending activity|double-stranded DNA binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					aggaagaagaggaggaggagg	0.279													5	100					0	0	0.000602	0	0
SCNN1D	6339	broad.mit.edu	37	1	1222261	1222262	+	Frame_Shift_Ins	INS	-	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:1222261_1222262insC	uc001adu.1	+	7	1157_1158	c.533_534insC	c.(532-534)GTCfs	p.V178fs	SCNN1D_uc001adt.1_Frame_Shift_Ins_p.V342fs|SCNN1D_uc001adw.2_Frame_Shift_Ins_p.V244fs|SCNN1D_uc001adx.2_5'UTR|SCNN1D_uc001adv.2_Frame_Shift_Ins_p.V178fs	NM_002978	NP_002969			sodium channel, nonvoltage-gated 1, delta												0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		TCCGCCACTGTCCCCCGCCACG	0.644													9	299	---	---	---	---					
VAMP3	9341	broad.mit.edu	37	1	7838212	7838214	+	In_Frame_Del	DEL	TCA	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:7838212_7838214delTCA	uc001aol.2	+	4	381_383	c.266_268delTCA	c.(265-270)TTCATC>TTC	p.I94del		NM_004781	NP_004772	Q15836	VAMP3_HUMAN	vesicle-associated membrane protein 3	94	Helical; Anchor for type IV membrane protein; (Potential).				cellular membrane fusion|positive regulation of receptor recycling|protein complex assembly|protein transport|retrograde transport, endosome to Golgi|substrate adhesion-dependent cell spreading|vesicle docking involved in exocytosis	cell junction|clathrin-coated vesicle|integral to membrane|recycling endosome|synapse|synaptosome	protein binding				0	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;6.33e-69)|GBM - Glioblastoma multiforme(8;2.07e-34)|Colorectal(212;1.36e-07)|COAD - Colon adenocarcinoma(227;1.38e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000805)|KIRC - Kidney renal clear cell carcinoma(229;0.000917)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		CTGGTTATCTTCATCATCATCAT	0.365													10	987	---	---	---	---					
SFRS4	6429	broad.mit.edu	37	1	29475219	29475221	+	In_Frame_Del	DEL	CTT	-	-	rs138237342	by1000genomes	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:29475219_29475221delCTT	uc001bro.2	-	6	1559_1561	c.1186_1188delAAG	c.(1186-1188)AAGdel	p.K396del	SFRS4_uc010ofy.1_3'UTR	NM_005626	NP_005617	Q08170	SRSF4_HUMAN	splicing factor, arginine/serine-rich 4	396	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding				0		Colorectal(325;0.00161)|Breast(348;0.0364)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0529)|Lung NSC(340;0.0654)|all_lung(284;0.074)|Ovarian(437;0.104)|Medulloblastoma(700;0.151)		Colorectal(126;1.01e-07)|COAD - Colon adenocarcinoma(152;6.21e-06)|STAD - Stomach adenocarcinoma(196;0.0196)|BRCA - Breast invasive adenocarcinoma(304;0.0531)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.138)		CAGTGTCTTCCTTCTTCTTCTTC	0.325													22	439	---	---	---	---					
AGL	178	broad.mit.edu	37	1	100378028	100378028	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:100378028delA	uc001dsi.1	+	29	4304	c.3904delA	c.(3904-3906)AAAfs	p.K1302fs	AGL_uc001dsj.1_Frame_Shift_Del_p.K1302fs|AGL_uc001dsk.1_Frame_Shift_Del_p.K1302fs|AGL_uc001dsl.1_Frame_Shift_Del_p.K1302fs|AGL_uc001dsm.1_Frame_Shift_Del_p.K1286fs|AGL_uc001dsn.1_Frame_Shift_Del_p.K1285fs	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	1302	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		GGAATTATCCAAAAAAAATAT	0.323													10	341	---	---	---	---					
FNDC7	163479	broad.mit.edu	37	1	109276138	109276138	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:109276138delA	uc001dvx.2	+	10	2124	c.2124delA	c.(2122-2124)CCAfs	p.P708fs	FNDC7_uc010ova.1_Frame_Shift_Del_p.P475fs	NM_001144937	NP_001138409	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	709	Fibronectin type-III 8.					extracellular region				ovary(1)|skin(1)	2		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		CTTTCTGTCCAAAAAAAATAT	0.363													7	322	---	---	---	---					
AP4B1	10717	broad.mit.edu	37	1	114438939	114438939	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:114438939delA	uc001eeb.2	-	8	1594	c.1451delT	c.(1450-1452)TTCfs	p.F484fs	uc001edv.1_Intron|AP4B1_uc001eec.2_Frame_Shift_Del_p.F316fs|AP4B1_uc001eed.2_Frame_Shift_Del_p.F484fs|AP4B1_uc010owp.1_Frame_Shift_Del_p.F385fs|AP4B1_uc001eea.1_Frame_Shift_Del_p.F278fs|AP4B1_uc001eee.1_Frame_Shift_Del_p.F11fs	NM_006594	NP_006585	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1	484					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			ovary(3)|central_nervous_system(1)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCGGGAGAGGAAAAGGCGCAG	0.458													7	559	---	---	---	---					
TRIM33	51592	broad.mit.edu	37	1	114968116	114968118	+	In_Frame_Del	DEL	TGT	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:114968116_114968118delTGT	uc001eew.2	-	9	1732_1734	c.1648_1650delACA	c.(1648-1650)ACAdel	p.T550del	TRIM33_uc010owr.1_In_Frame_Del_p.T140del|TRIM33_uc010ows.1_In_Frame_Del_p.T158del|TRIM33_uc001eex.2_In_Frame_Del_p.T550del	NM_015906	NP_056990	Q9UPN9	TRI33_HUMAN	tripartite motif-containing 33 protein isoform	550	Poly-Thr.				negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			lung(4)|central_nervous_system(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	11	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GATGCTGTTGTGTTGTTGTTGTT	0.429			T	RET	papillary thyroid								9	1153	---	---	---	---					
HFE2	148738	broad.mit.edu	37	1	145415369	145415371	+	In_Frame_Del	DEL	GAG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:145415369_145415371delGAG	uc001eni.2	+	3	513_515	c.188_190delGAG	c.(187-192)CGAGGA>CGA	p.G69del	NBPF10_uc001emp.3_Intron|HFE2_uc001enj.2_Intron|HFE2_uc001enk.2_5'UTR|HFE2_uc001enl.2_Intron	NM_213653	NP_998818	Q6ZVN8	RGMC_HUMAN	hemojuvelin isoform a precursor	69	Poly-Gly.			G -> GG (in Ref. 3; ABC40718).	axon guidance	anchored to membrane				ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GGAGCACTTCGAGGAGGAGGAGG	0.626													11	362	---	---	---	---					
KIAA0907	22889	broad.mit.edu	37	1	155886422	155886423	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:155886422_155886423delCT	uc001fmi.1	-	12	1570_1571	c.1546_1547delAG	c.(1546-1548)AGGfs	p.R516fs	KIAA0907_uc001fmj.1_Frame_Shift_Del_p.R516fs|KIAA0907_uc009wrk.1_Frame_Shift_Del_p.R373fs|KIAA0907_uc009wrl.1_RNA	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	516											0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			TTACCTGTCCCTCTCTCTCTCT	0.396													41	776	---	---	---	---					
NOS1AP	9722	broad.mit.edu	37	1	162326888	162326890	+	In_Frame_Del	DEL	CAG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:162326888_162326890delCAG	uc001gbv.2	+	8	1288_1290	c.901_903delCAG	c.(901-903)CAGdel	p.Q306del	NOS1AP_uc010pkr.1_In_Frame_Del_p.Q301del|NOS1AP_uc010pks.1_RNA|NOS1AP_uc001gbw.2_In_Frame_Del_p.Q301del	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor	306	Poly-Gln.				regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			lung(2)|upper_aerodigestive_tract(1)	3	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			gcagctcctccagcagcAGCAGC	0.512													7	157	---	---	---	---					
APOBEC4	403314	broad.mit.edu	37	1	183616826	183616828	+	In_Frame_Del	DEL	TTC	-	-	rs141411396		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:183616826_183616828delTTC	uc001gqn.2	-	2	1361_1363	c.1089_1091delGAA	c.(1087-1092)AAGAAA>AAA	p.363_364KK>K	RGL1_uc010pof.1_Intron|RGL1_uc001gqm.2_Intron|RGL1_uc010pog.1_Intron|RGL1_uc010poh.1_Intron	NM_203454	NP_982279	Q8WW27	ABEC4_HUMAN	apolipoprotein B	363_364					mRNA processing		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding				0						TTTCTTCCCTTTCTTCTTCTTCT	0.419													8	554	---	---	---	---					
MTR	4548	broad.mit.edu	37	1	237024474	237024474	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:237024474delA	uc001hyi.3	+	20	2516	c.2093delA	c.(2092-2094)CAAfs	p.Q698fs	MTR_uc010pxw.1_Frame_Shift_Del_p.Q291fs|MTR_uc010pxx.1_Intron|MTR_uc010pxy.1_Frame_Shift_Del_p.Q552fs	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	698	B12-binding N-terminal.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	AGGTTAAACCAAAAAAAATAT	0.279													9	275	---	---	---	---					
FMN2	56776	broad.mit.edu	37	1	240371335	240371337	+	In_Frame_Del	DEL	CCC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:240371335_240371337delCCC	uc010pyd.1	+	5	3448_3450	c.3223_3225delCCC	c.(3223-3225)CCCdel	p.P1079del	FMN2_uc010pye.1_In_Frame_Del_p.P1083del	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1079	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AGCGGGCATACCCCCTCCGCCCC	0.729													8	154	---	---	---	---					
SFMBT2	57713	broad.mit.edu	37	10	7212995	7212997	+	In_Frame_Del	DEL	CTC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:7212995_7212997delCTC	uc009xio.1	-	20	2528_2530	c.2437_2439delGAG	c.(2437-2439)GAGdel	p.E813del	SFMBT2_uc001ijn.1_In_Frame_Del_p.E813del|SFMBT2_uc010qay.1_In_Frame_Del_p.E648del	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	813					regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						GAACCAGTCTCTCCTCCTCCTCC	0.596													7	744	---	---	---	---					
KIAA1462	57608	broad.mit.edu	37	10	30316501	30316503	+	In_Frame_Del	DEL	CTG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:30316501_30316503delCTG	uc001iux.2	-	2	2633_2635	c.2574_2576delCAG	c.(2572-2577)AGCAGT>AGT	p.858_859SS>S	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_In_Frame_Del_p.720_721SS>S|KIAA1462_uc009xle.1_In_Frame_Del_p.858_859SS>S	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	858_859	Ser-rich.									ovary(4)	4						ACTCTCCTCActgctgctgctgc	0.463													11	274	---	---	---	---					
ANK3	288	broad.mit.edu	37	10	61831290	61831290	+	Frame_Shift_Del	DEL	T	-	-	rs28932171	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:61831290delT	uc001jky.2	-	37	9541	c.9349delA	c.(9349-9351)ATCfs	p.I3117fs	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3117					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TGACTTATGATTTTTTTTACA	0.403													11	749	---	---	---	---					
ARID5B	84159	broad.mit.edu	37	10	63852298	63852298	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:63852298delA	uc001jlt.1	+	10	3102	c.3076delA	c.(3076-3078)AAAfs	p.K1026fs		NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	1026					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					GATTGCAGGGAAAAAGGCCCG	0.607													7	506	---	---	---	---					
FAS	355	broad.mit.edu	37	10	90768708	90768708	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:90768708delT	uc001kfr.2	+	4	743	c.397delT	c.(397-399)TTTfs	p.F133fs	FAS_uc010qna.1_RNA|FAS_uc001kfs.2_Frame_Shift_Del_p.F133fs|FAS_uc001kft.2_Frame_Shift_Del_p.F133fs|FAS_uc010qnb.1_Intron|FAS_uc010qnc.1_Intron|FAS_uc001kfw.2_Intron|FAS_uc010qnd.1_Intron|FAS_uc010qne.1_Intron|FAS_uc009xtp.2_RNA	NM_000043	NP_000034	P25445	TNR6_HUMAN	tumor necrosis factor receptor superfamily,	133	TNFR-Cys 3.|Extracellular (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|anti-apoptosis|cellular response to mechanical stimulus|positive regulation of necrotic cell death	cytosol|extracellular region|integral to membrane|soluble fraction	identical protein binding|kinase binding			upper_aerodigestive_tract(1)|breast(1)	2		Colorectal(252;0.0161)		Colorectal(12;0.000136)|COAD - Colon adenocarcinoma(12;0.000193)		TAAACCAAACTTTTTTTGTAA	0.368									Autoimmune_Lymphoproliferative_syndrome_type_I				8	2244	---	---	---	---					
SLIT1	6585	broad.mit.edu	37	10	98778793	98778794	+	Frame_Shift_Ins	INS	-	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:98778793_98778794insG	uc001kmw.2	-	27	3069_3070	c.2817_2818insC	c.(2815-2820)ACCTGCfs	p.T939fs		NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	939_940	EGF-like 1.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		TCGTTGTGGCAGGTGCCCTGGT	0.391													8	270	---	---	---	---					
ABCC2	1244	broad.mit.edu	37	10	101559000	101559000	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:101559000delA	uc001kqf.2	+	8	1043	c.904delA	c.(904-906)AAAfs	p.K302fs		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	302	Cytoplasmic (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GTCTGGGACCAAAAAAGATGT	0.403													7	651	---	---	---	---					
SCD	6319	broad.mit.edu	37	10	102107836	102107838	+	In_Frame_Del	DEL	ACC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:102107836_102107838delACC	uc001kqy.2	+	2	533_535	c.43_45delACC	c.(43-45)ACCdel	p.T19del		NM_005063	NP_005054	O00767	ACOD_HUMAN	stearoyl-CoA desaturase 1	19	Cytoplasmic (Potential).				fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity				0		Colorectal(252;0.0323)		Epithelial(162;1.97e-10)|all cancers(201;1.73e-08)		TAGCTCCTATACCACCACCACCA	0.581													12	582	---	---	---	---					
NOLC1	9221	broad.mit.edu	37	10	103919000	103919002	+	In_Frame_Del	DEL	AGC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:103919000_103919002delAGC	uc001kuo.2	+	6	893_895	c.658_660delAGC	c.(658-660)AGCdel	p.S227del	NOLC1_uc001kup.2_In_Frame_Del_p.S227del|NOLC1_uc001kuq.2_In_Frame_Del_p.S228del|NOLC1_uc009xxb.1_5'UTR|NOLC1_uc001kur.2_5'UTR	NM_004741	NP_004732	Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	227	11 X 12 AA approximate repeats of an acidic serine cluster.|Acidic serine cluster 4.|Interacts with RPA194.				mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)		tagcagcagtagcagcagcagca	0.394													8	421	---	---	---	---					
TACC2	10579	broad.mit.edu	37	10	123970380	123970380	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:123970380delC	uc001lfv.2	+	9	6800	c.6440delC	c.(6439-6441)ACCfs	p.T2147fs	TACC2_uc001lfw.2_Frame_Shift_Del_p.T293fs|TACC2_uc009xzx.2_Frame_Shift_Del_p.T2102fs|TACC2_uc010qtv.1_Frame_Shift_Del_p.T2151fs|TACC2_uc001lfx.2_5'UTR|TACC2_uc001lfy.2_5'UTR|TACC2_uc001lfz.2_Frame_Shift_Del_p.T225fs|TACC2_uc001lga.2_Frame_Shift_Del_p.T225fs|TACC2_uc009xzy.2_Frame_Shift_Del_p.T225fs|TACC2_uc001lgb.2_Frame_Shift_Del_p.T182fs|TACC2_uc010qtw.1_Frame_Shift_Del_p.T242fs	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2147						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CCCACAGAGACCCCCCCAGTG	0.522													9	751	---	---	---	---					
NLRP6	171389	broad.mit.edu	37	11	281553	281555	+	In_Frame_Del	DEL	GAG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:281553_281555delGAG	uc010qvs.1	+	4	1819_1821	c.1819_1821delGAG	c.(1819-1821)GAGdel	p.E611del	NLRP6_uc010qvt.1_In_Frame_Del_p.E611del	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	611	Poly-Glu.					cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		CGAAGAGCCAGAGGAGGAGGAGG	0.670													19	438	---	---	---	---					
TSPAN4	7106	broad.mit.edu	37	11	864443	864445	+	In_Frame_Del	DEL	CTG	-	-	rs61867552	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:864443_864445delCTG	uc001lsd.1	+	5	471_473	c.262_264delCTG	c.(262-264)CTGdel	p.L92del	TSPAN4_uc001lse.1_In_Frame_Del_p.L28del|TSPAN4_uc001lsf.1_In_Frame_Del_p.L92del|TSPAN4_uc001lsg.1_In_Frame_Del_p.L92del|TSPAN4_uc001lsh.1_In_Frame_Del_p.L92del|TSPAN4_uc001lsi.1_In_Frame_Del_p.L92del|TSPAN4_uc001lsj.1_In_Frame_Del_p.L92del	NM_003271	NP_003262	O14817	TSN4_HUMAN	tetraspanin 4 isoform a	92	Helical; (Potential).				protein complex assembly	integral to plasma membrane				breast(1)	1		all_cancers(49;2.64e-08)|all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)		all cancers(45;4.32e-25)|Epithelial(43;3.29e-24)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACAGTTCTTCCTGCTGCTGCTGC	0.650													30	504	---	---	---	---					
APBB1	322	broad.mit.edu	37	11	6432090	6432092	+	In_Frame_Del	DEL	TCC	-	-	rs145320037		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:6432090_6432092delTCC	uc001mdb.1	-	2	586_588	c.486_488delGGA	c.(484-489)GAGGAT>GAT	p.E162del	APBB1_uc001mdc.1_In_Frame_Del_p.E162del|APBB1_uc010rah.1_Intron	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	162	Glu-rich.				apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding	p.E162K(1)		breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		atcatcatcatcctcctcctcct	0.404													8	73	---	---	---	---					
OR10A2	341276	broad.mit.edu	37	11	6891253	6891255	+	In_Frame_Del	DEL	TTC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:6891253_6891255delTTC	uc001meu.1	+	1	268_270	c.268_270delTTC	c.(268-270)TTCdel	p.F94del		NM_001004460	NP_001004460	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A,	94	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TCAGATGTATTTCTTCTTCTTCT	0.517													8	498	---	---	---	---					
CALCA	796	broad.mit.edu	37	11	14991489	14991490	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:14991489_14991490delCT	uc001mlt.1	-	3	293_294	c.218_219delAG	c.(217-219)GAGfs	p.E73fs	CALCA_uc001mlu.1_RNA|CALCA_uc001mlv.1_Frame_Shift_Del_p.E73fs|CALCA_uc001mlw.1_Frame_Shift_Del_p.E73fs	NM_001033953	NP_001029125	P06881	CALCA_HUMAN	calcitonin isoform CGRP preproprotein	73					activation of adenylate cyclase activity|cell-cell signaling|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|endothelial cell migration|endothelial cell proliferation|leukocyte cell-cell adhesion|negative regulation of blood pressure|negative regulation of bone resorption|negative regulation of calcium ion transport into cytosol|negative regulation of osteoclast differentiation|neurological system process involved in regulation of systemic arterial blood pressure|positive regulation of interleukin-1 alpha production|positive regulation of interleukin-8 production|positive regulation of macrophage differentiation|positive regulation of vasodilation|regulation of blood pressure|vasculature development|vasodilation	cytosol|extracellular space	hormone activity			central_nervous_system(1)	1					Phentolamine(DB00692)	ACCTGGAGCCCTCTCTCTCTTG	0.624											OREG0020791	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	405	---	---	---	---					
MYBPC3	4607	broad.mit.edu	37	11	47359101	47359103	+	In_Frame_Del	DEL	TCT	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:47359101_47359103delTCT	uc001nfa.3	-	24	2496_2498	c.2441_2443delAGA	c.(2440-2445)AAGAGC>AGC	p.K814del	MYBPC3_uc010rhl.1_Intron	NM_000256	NP_000247	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	813	Fibronectin type-III 1.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			ovary(2)|central_nervous_system(1)	3				Lung(87;0.176)		CACCGGTAGCTCTTCTTCTTCTT	0.601													10	266	---	---	---	---					
PRG2	5553	broad.mit.edu	37	11	57156679	57156681	+	In_Frame_Del	DEL	TCT	-	-	rs77900153	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:57156679_57156681delTCT	uc001njz.2	-	2	195_197	c.168_170delAGA	c.(166-171)GAAGAG>GAG	p.56_57EE>E	PRG2_uc001njw.1_RNA|PRG2_uc001njx.1_RNA|PRG2_uc001njy.1_RNA|PRG2_uc001nka.2_In_Frame_Del_p.56_57EE>E|PRG2_uc001nkb.2_In_Frame_Del_p.56_57EE>E|PRG2_uc001nkd.2_In_Frame_Del_p.56_57EE>E|PRG2_uc001nkc.2_In_Frame_Del_p.56_57EE>E|PRG2_uc001nke.2_In_Frame_Del_p.336_337EE>E	NM_002728	NP_002719	P13727	PRG2_HUMAN	proteoglycan 2 preproprotein	56_57					defense response to bacterium|immune response	extracellular region|transport vesicle	heparin binding|sugar binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Sargramostim(DB00020)	CCACTCCTCCTCTTCCTCCAGCT	0.547													10	440	---	---	---	---					
UVRAG	7405	broad.mit.edu	37	11	75694430	75694431	+	Splice_Site	INS	-	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:75694430_75694431insA	uc001oxc.2	+	8	941	c.700_splice	c.e8-1	p.K234_splice	UVRAG_uc010rrw.1_Splice_Site_p.K133_splice|UVRAG_uc001oxd.2_Splice_Site|UVRAG_uc010rrx.1_5'UTR|UVRAG_uc009yuh.1_Splice_Site	NM_003369	NP_003360	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated						DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			skin(4)|lung(2)	6						TATTTATTTAGAAAAAAAAAAG	0.302													14	158	---	---	---	---					
DDX10	1662	broad.mit.edu	37	11	108559769	108559769	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:108559769delT	uc001pkm.2	+	7	1020	c.955delT	c.(955-957)TTTfs	p.F319fs	DDX10_uc001pkl.1_Frame_Shift_Del_p.F319fs	NM_004398	NP_004389	Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	319	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		GAGCATTGTATTTTTTTCCAG	0.353			T	NUP98	AML*								7	1150	---	---	---	---					
IFT46	56912	broad.mit.edu	37	11	118427683	118427685	+	In_Frame_Del	DEL	ATC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:118427683_118427685delATC	uc001ptp.1	-	4	499_501	c.121_123delGAT	c.(121-123)GATdel	p.D41del	IFT46_uc001pto.1_In_Frame_Del_p.D92del|IFT46_uc009zaf.1_In_Frame_Del_p.D92del	NM_020153	NP_064538	Q9NQC8	IFT46_HUMAN	IFT46	41	Asp/Glu-rich (highly acidic).				flagellum assembly|intraflagellar transport|protein stabilization	microtubule basal body|microtubule-based flagellum|nucleus	protein C-terminus binding				0						TTTCAGATGAatcatcatcatca	0.424													9	342	---	---	---	---					
CBL	867	broad.mit.edu	37	11	119149356	119149358	+	In_Frame_Del	DEL	ATG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:119149356_119149358delATG	uc001pwe.2	+	9	1502_1504	c.1364_1366delATG	c.(1363-1368)TATGAT>TAT	p.D460del		NM_005188	NP_005179	P22681	CBL_HUMAN	Cas-Br-M (murine) ecotropic retroviral	460	Asp/Glu-rich (acidic).				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding	p.D460del(1)|p.E366_K477del(1)		haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		TCCCCAAATTATGATGATGATGA	0.473									CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				10	252	---	---	---	---					
PVRL1	5818	broad.mit.edu	37	11	119535678	119535680	+	In_Frame_Del	DEL	CCT	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:119535678_119535680delCCT	uc001pwv.2	-	6	1503_1505	c.1331_1333delAGG	c.(1330-1335)GAGGGC>GGC	p.E444del	PVRL1_uc001pwu.1_Intron	NM_002855	NP_002846	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 isoform 1	444	Poly-Glu.|Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		CCTCCACCGCcctcctcctcctc	0.576													9	109	---	---	---	---					
CHD4	1108	broad.mit.edu	37	12	6711207	6711209	+	In_Frame_Del	DEL	CTT	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:6711207_6711209delCTT	uc001qpo.2	-	4	519_521	c.355_357delAAG	c.(355-357)AAGdel	p.K119del	CHD4_uc001qpn.2_In_Frame_Del_p.K112del|CHD4_uc001qpp.2_In_Frame_Del_p.K116del	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	119	Poly-Lys.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TAGGTCCAAGCTTCTTCTTCTTC	0.468													8	120	---	---	---	---					
CASC1	55259	broad.mit.edu	37	12	25314066	25314068	+	In_Frame_Del	DEL	CTC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:25314066_25314068delCTC	uc001rgl.2	-	2	149_151	c.67_69delGAG	c.(67-69)GAGdel	p.E23del	CASC1_uc001rgk.2_In_Frame_Del_p.E29del|CASC1_uc001rgm.3_In_Frame_Del_p.E87del|CASC1_uc001rgj.2_5'UTR|CASC1_uc010sje.1_Intron|CASC1_uc010sjf.1_5'UTR|CASC1_uc010sjg.1_In_Frame_Del_p.E23del|CASC1_uc010sjh.1_RNA	NM_001082973	NP_001076442	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1 isoform b	23	Glu-rich.									ovary(2)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			TCAGTCGTCTCTCCTCCTCCTCT	0.365													9	928	---	---	---	---					
KLHDC5	57542	broad.mit.edu	37	12	27950769	27950769	+	Frame_Shift_Del	DEL	G	-	-	rs145908611	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:27950769delG	uc001rij.2	+	3	1265	c.1188delG	c.(1186-1188)GTGfs	p.V396fs	KLHDC5_uc009zjj.2_RNA	NM_020782	NP_065833	Q9P2K6	KLDC5_HUMAN	kelch domain containing 5	396	Kelch 5.									ovary(1)|central_nervous_system(1)	2	Lung SC(9;0.0873)					TCTACATCGTGGGGGGGTGTC	0.592													7	493	---	---	---	---					
OR10A7	121364	broad.mit.edu	37	12	55615114	55615116	+	In_Frame_Del	DEL	CTT	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:55615114_55615116delCTT	uc010spf.1	+	1	306_308	c.306_308delCTT	c.(304-309)TACTTC>TAC	p.F107del		NM_001005280	NP_001005280	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A,	107	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)	4						CCCAGATGTACTTCTTCTTCTTC	0.414													11	698	---	---	---	---					
SMARCC2	6601	broad.mit.edu	37	12	56558379	56558381	+	In_Frame_Del	DEL	AGG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:56558379_56558381delAGG	uc001skb.2	-	27	3380_3382	c.3274_3276delCCT	c.(3274-3276)CCTdel	p.P1092del	SMARCC2_uc001skd.2_Intron|SMARCC2_uc001ska.2_Intron|SMARCC2_uc001skc.2_Intron|SMARCC2_uc010sqf.1_Intron	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	1092	Pro-rich.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TGGATGGAGCAGGAGGAGGAGGA	0.591													8	151	---	---	---	---					
MARS	4141	broad.mit.edu	37	12	57883053	57883053	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:57883053delT	uc001sog.2	+	3	227	c.204delT	c.(202-204)TATfs	p.Y68fs	ARHGAP9_uc001sod.2_5'Flank|ARHGAP9_uc001soe.1_5'Flank|MARS_uc001sof.1_RNA|MARS_uc010srp.1_Intron|MARS_uc010srq.1_5'UTR	NM_004990	NP_004981	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	68					methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			ovary(3)|central_nervous_system(1)|pancreas(1)	5			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	TGGGCAGATATTTTTTTTTGT	0.488													9	212	---	---	---	---					
B4GALNT1	2583	broad.mit.edu	37	12	58025102	58025103	+	Frame_Shift_Ins	INS	-	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:58025102_58025103insC	uc001spg.1	-	3	695_696	c.263_264insG	c.(262-264)GGCfs	p.G88fs	B4GALNT1_uc010sru.1_Intron|B4GALNT1_uc010srv.1_Frame_Shift_Ins_p.G88fs|B4GALNT1_uc001sph.2_Frame_Shift_Ins_p.G88fs|B4GALNT1_uc001spi.2_Frame_Shift_Ins_p.G88fs|B4GALNT1_uc010srw.1_Frame_Shift_Ins_p.G165fs	NM_001478	NP_001469	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	88	Lumenal (Potential).				lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity				0	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			GGAGGGGGAGGCCCCCCCCACT	0.589													8	462	---	---	---	---					
TMPO	7112	broad.mit.edu	37	12	98921671	98921672	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:98921671_98921672insA	uc001tfj.2	+	2	524_525	c.287_288insA	c.(286-288)ACAfs	p.T96fs	TMPO_uc001tfi.1_Frame_Shift_Ins_p.T96fs|TMPO_uc001tfk.2_Frame_Shift_Ins_p.T96fs|TMPO_uc001tfl.2_RNA|TMPO_uc001tfh.1_Frame_Shift_Ins_p.T96fs	NM_001032283	NP_001027454	P42167	LAP2B_HUMAN	thymopoietin isoform beta	96	Linker.|Nucleoplasmic (Potential).					integral to membrane|nuclear inner membrane	DNA binding|lamin binding			ovary(2)	2						CAGAAAGCCACAAAAAAAACTG	0.332													10	353	---	---	---	---					
CUX2	23316	broad.mit.edu	37	12	111758235	111758237	+	In_Frame_Del	DEL	TCC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:111758235_111758237delTCC	uc001tsa.1	+	17	2575_2577	c.2422_2424delTCC	c.(2422-2424)TCCdel	p.S813del		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	813	Poly-Ser.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GCCCTCGCTGTCCTCCTCCTCCT	0.749													8	210	---	---	---	---					
MIR620	693205	broad.mit.edu	37	12	116586415	116586416	+	RNA	DEL	TA	-	-	rs10549054		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:116586415_116586416delTA	hsa-mir-620|MI0003634	-			c.44_45delTA			MED13L_uc001tvw.2_Intron																	0						tggagatatctatatatatata	0.188													7	15	---	---	---	---					
POP5	51367	broad.mit.edu	37	12	121017154	121017156	+	In_Frame_Del	DEL	CTC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:121017154_121017156delCTC	uc001tys.2	-	5	489_491	c.457_459delGAG	c.(457-459)GAGdel	p.E153del	POP5_uc001tyt.2_In_Frame_Del_p.E103del	NM_015918	NP_057002	Q969H6	POP5_HUMAN	processing of precursor 5 isoform a	153					tRNA processing		protein binding|ribonuclease P activity				0	all_neural(191;0.077)|Medulloblastoma(191;0.0922)					CCTCACCTGACTCCTCCTCCTCC	0.517													10	556	---	---	---	---					
HSPH1	10808	broad.mit.edu	37	13	31715381	31715382	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr13:31715381_31715382insT	uc001utj.2	-	13	2129_2130	c.1731_1732insA	c.(1729-1734)AAAGTTfs	p.K577fs	HSPH1_uc001utk.2_Frame_Shift_Ins_p.K533fs|HSPH1_uc010aaw.2_Frame_Shift_Ins_p.K536fs|HSPH1_uc001utl.2_Frame_Shift_Ins_p.K579fs|HSPH1_uc010tds.1_Frame_Shift_Ins_p.K501fs	NM_006644	NP_006635	Q92598	HS105_HUMAN	heat shock 105kD	577_578					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding				0		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		GGCTGGTCAACTTTTTTTTCAT	0.376													8	315	---	---	---	---					
LRCH1	23143	broad.mit.edu	37	13	47243183	47243186	+	Frame_Shift_Del	DEL	CCTG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr13:47243183_47243186delCCTG	uc001vbj.2	+	3	707_710	c.471_474delCCTG	c.(469-474)GCCCTGfs	p.A157fs	LRCH1_uc010acp.2_Frame_Shift_Del_p.A157fs|LRCH1_uc001vbk.2_Frame_Shift_Del_p.A157fs|LRCH1_uc001vbl.3_Frame_Shift_Del_p.A157fs	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	157_158	LRR 3.									ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		AGCTGTCCGCCCTGCCTGCCTGCC	0.436													7	736	---	---	---	---					
ABCC4	10257	broad.mit.edu	37	13	95696016	95696016	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr13:95696016delT	uc001vmd.3	-	29	3774	c.3655delA	c.(3655-3657)ATCfs	p.I1219fs	ABCC4_uc010afj.2_Intron|ABCC4_uc010afk.2_Frame_Shift_Del_p.I1172fs	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	1219	ABC transporter 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	TTCTCCCGGATTTTTTTTTGT	0.378													17	397	---	---	---	---					
OR4K5	79317	broad.mit.edu	37	14	20389294	20389294	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr14:20389294delT	uc010tkw.1	+	1	529	c.529delT	c.(529-531)TTTfs	p.F177fs		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	177	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGTAGACAGCTTTTTTTGTGA	0.423													9	1377	---	---	---	---					
LTB4R	1241	broad.mit.edu	37	14	24785074	24785074	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr14:24785074delT	uc001wos.2	+	2	538	c.217delT	c.(217-219)TTTfs	p.F73fs	LTB4R_uc010alp.2_Frame_Shift_Del_p.F73fs|LTB4R_uc001wou.2_Frame_Shift_Del_p.F73fs	NM_001143919	NP_001137391	Q15722	LT4R1_HUMAN	leukotriene B4 receptor	73	Helical; Name=2; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular component movement|immune response|inflammatory response|muscle contraction	integral to plasma membrane	nucleotide binding				0				GBM - Glioblastoma multiforme(265;0.018)		CACTGCTCCCTTTTTCCTTCA	0.582													7	571	---	---	---	---					
MGAT2	4247	broad.mit.edu	37	14	50088320	50088321	+	Frame_Shift_Ins	INS	-	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr14:50088320_50088321insC	uc001wwr.2	+	1	832_833	c.334_335insC	c.(334-336)ACCfs	p.T112fs	SDCCAG1_uc010anj.1_Intron|RPL36AL_uc001wwq.1_5'Flank	NM_002408	NP_002399	Q10469	MGAT2_HUMAN	mannosyl (alpha-1,6-)-glycoprotein	112	Lumenal (Potential).				oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity				0	all_epithelial(31;0.0021)|Breast(41;0.0124)					TAAGGCTGGCACCTGGGCCCCC	0.614													12	577	---	---	---	---					
ADAM6	8755	broad.mit.edu	37	14	106691799	106691801	+	RNA	DEL	ACT	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr14:106691799_106691801delACT	uc010tyt.1	-	754		c.20562_20564delAGT								Parts of antibodies, mostly variable regions.												0						AGTATATGTAACTACTACTACTA	0.517													7	955	---	---	---	---					
C15orf24	56851	broad.mit.edu	37	15	34393991	34393993	+	In_Frame_Del	DEL	AGC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr15:34393991_34393993delAGC	uc001zhm.2	-	1	61_63	c.48_50delGCT	c.(46-51)CTGCTA>CTA	p.16_17LL>L	C15orf24_uc001zhn.2_5'UTR|PGBD4_uc001zho.2_5'Flank	NM_020154	NP_064539	Q9NPA0	CO024_HUMAN	chromosome 15 open reading frame 24 precursor	16_17						cytoplasm|integral to membrane	carbohydrate binding|carboxypeptidase activity|purine nucleotide binding				0		all_lung(180;1.76e-08)		all cancers(64;2.02e-17)|GBM - Glioblastoma multiforme(113;2.15e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)		ATCCCCCGATAGCAGCAGCAGCA	0.665													12	586	---	---	---	---					
TTBK2	146057	broad.mit.edu	37	15	43038023	43038024	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr15:43038023_43038024insT	uc001zqo.2	-	15	4143_4144	c.3704_3705insA	c.(3703-3705)AAGfs	p.K1235fs	TTBK2_uc010bcy.2_Frame_Shift_Ins_p.K1166fs|uc001zqn.2_5'Flank	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	1235					cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		CTGGCTTACTCTTCCCTTGGGG	0.535													12	794	---	---	---	---					
TTBK2	146057	broad.mit.edu	37	15	43038025	43038026	+	Frame_Shift_Ins	INS	-	C	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr15:43038025_43038026insC	uc001zqo.2	-	15	4141_4142	c.3702_3703insG	c.(3700-3705)GGGAAGfs	p.G1234fs	TTBK2_uc010bcy.2_Frame_Shift_Ins_p.G1165fs|uc001zqn.2_5'Flank	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	1234_1235					cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		GGCTTACTCTTCCCTTGGGGGG	0.540													22	803	---	---	---	---					
WDR72	256764	broad.mit.edu	37	15	53992038	53992038	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr15:53992038delA	uc002acj.2	-	13	1716	c.1674delT	c.(1672-1674)TTTfs	p.F558fs	WDR72_uc010bfi.1_Frame_Shift_Del_p.F558fs	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	558	WD 8.									lung(1)|skin(1)	2				all cancers(107;0.0511)		TCCTCACAGGAAAAAGGTGCT	0.463													7	857	---	---	---	---					
SLC24A1	9187	broad.mit.edu	37	15	65943128	65943130	+	In_Frame_Del	DEL	GAG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr15:65943128_65943130delGAG	uc010ujf.1	+	7	2928_2930	c.2641_2643delGAG	c.(2641-2643)GAGdel	p.E890del	SLC24A1_uc010ujd.1_In_Frame_Del_p.E872del|SLC24A1_uc010uje.1_In_Frame_Del_p.E872del|SLC24A1_uc010ujg.1_In_Frame_Del_p.E890del|SLC24A1_uc010ujh.1_In_Frame_Del_p.E872del|SLC24A1_uc010uji.1_In_Frame_Del_p.E217del	NM_004727	NP_004718	O60721	NCKX1_HUMAN	solute carrier family 24	890	Cytoplasmic (Potential).|Poly-Glu.				response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity				0						gcaggaggaagaggaggaggagg	0.281													8	105	---	---	---	---					
GOLGA6L5	374650	broad.mit.edu	37	15	85055754	85055756	+	RNA	DEL	CTC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr15:85055754_85055756delCTC	uc002bkm.2	-	6		c.804_806delGAG				NR_003246				Homo sapiens cDNA FLJ33459 fis, clone BRAMY2000585.												0						CACGTAGCCTCTCCTCCTGTTCA	0.547													10	105	---	---	---	---					
CHD2	1106	broad.mit.edu	37	15	93540315	93540316	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr15:93540315_93540316insA	uc002bsp.2	+	29	4299_4300	c.3724_3725insA	c.(3724-3726)GAAfs	p.E1242fs	CHD2_uc002bso.1_Frame_Shift_Ins_p.E1242fs	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1242					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			GGACCCTGAAGAAAAAAAAAAG	0.347													16	304	---	---	---	---					
CREBBP	1387	broad.mit.edu	37	16	3817721	3817721	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:3817721delT	uc002cvv.2	-	16	3454	c.3250delA	c.(3250-3252)ATCfs	p.I1084fs	CREBBP_uc002cvw.2_Frame_Shift_Del_p.I1046fs	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1084					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding	p.I1084fs*15(1)		haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		AATGGCCTACTTTTTTTGCGC	0.398			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				7	424	---	---	---	---					
NTAN1	123803	broad.mit.edu	37	16	15131931	15131931	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:15131931delT	uc002ddd.2	-	10	895	c.890delA	c.(889-891)AATfs	p.N297fs	PDXDC1_uc002ddc.2_Intron|NTAN1_uc010uzo.1_Frame_Shift_Del_p.N192fs	NM_173474	NP_775745	Q96AB6	NTAN1_HUMAN	N-terminal Asn amidase	297						cytoplasm					0						GCCATCTTCATTTTTTTTGTA	0.383													9	461	---	---	---	---					
C16orf62	57020	broad.mit.edu	37	16	19580800	19580802	+	In_Frame_Del	DEL	TCC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:19580800_19580802delTCC	uc002dgn.1	+	3	184_186	c.172_174delTCC	c.(172-174)TCCdel	p.S64del	C16orf62_uc002dgo.1_In_Frame_Del_p.S64del|C16orf62_uc010vas.1_5'UTR|C16orf62_uc002dgm.1_In_Frame_Del_p.S64del	NM_020314	NP_064710	Q7Z3J2	CP062_HUMAN	hypothetical protein LOC57020	64	Ser-rich.					integral to membrane				ovary(1)	1						TTCTTCCACGTCCTCCTCCTCCT	0.562													12	269	---	---	---	---					
EIF3CL	728689	broad.mit.edu	37	16	28734579	28734581	+	In_Frame_Del	DEL	GAG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:28734579_28734581delGAG	uc010byj.2	+	9	960_962	c.871_873delGAG	c.(871-873)GAGdel	p.E295del	uc010vct.1_Intron|EIF3CL_uc010byi.2_In_Frame_Del_p.E294del|EIF3CL_uc002dqs.3_In_Frame_Del_p.E294del|EIF3C_uc002dqt.3_In_Frame_Del_p.E294del|EIF3CL_uc010vcy.1_In_Frame_Del_p.E284del|EIF3C_uc002dqu.3_In_Frame_Del_p.E294del|EIF3CL_uc002dqv.3_In_Frame_Del_p.E40del	NM_001099661	NP_001093131	B5ME19	B5ME19_HUMAN	eukaryotic translation initiation factor 3,	295						eukaryotic translation initiation factor 3 complex	translation initiation factor activity				0						GCGCCTGGATGAGGAGGAGGAGG	0.562													10	2512	---	---	---	---					
TAOK2	9344	broad.mit.edu	37	16	29998498	29998500	+	In_Frame_Del	DEL	CTG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:29998498_29998500delCTG	uc002dva.1	+	16	3688_3690	c.2905_2907delCTG	c.(2905-2907)CTGdel	p.L974del	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Intron|TAOK2_uc002dvc.1_Intron|TAOK2_uc010bzm.1_In_Frame_Del_p.L981del|TAOK2_uc002dvd.1_In_Frame_Del_p.L801del	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	974	Leu-rich.|Helical; (Potential).				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						CCTGCCCCTCCTGCTGCTGCTGC	0.709													7	237	---	---	---	---					
SRCAP	10847	broad.mit.edu	37	16	30736314	30736314	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:30736314delC	uc002dze.1	+	25	5954	c.5569delC	c.(5569-5571)CCCfs	p.P1857fs	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Frame_Shift_Del_p.P1652fs|SRCAP_uc010bzz.1_Frame_Shift_Del_p.P1427fs	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1857	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			GCGCTCTGGTCCCCCCAGCCC	0.612													7	946	---	---	---	---					
NOB1	28987	broad.mit.edu	37	16	69782978	69782980	+	In_Frame_Del	DEL	TCC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:69782978_69782980delTCC	uc002exs.2	-	6	583_585	c.567_569delGGA	c.(565-570)GAGGAA>GAA	p.189_190EE>E		NM_014062	NP_054781	Q9ULX3	NOB1_HUMAN	nin one binding protein	189_190	Poly-Glu.					nucleus	metal ion binding|protein binding				0						CCCGTTTTCTTCCTCCTCCTCCT	0.522													16	388	---	---	---	---					
EPN2	22905	broad.mit.edu	37	17	19232950	19232950	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:19232950delA	uc002gvd.3	+	9	1849	c.1401delA	c.(1399-1401)TCAfs	p.S467fs	EPN2_uc010cql.1_Frame_Shift_Del_p.S176fs|EPN2_uc002gve.3_Frame_Shift_Del_p.S410fs|EPN2_uc002gvf.3_Frame_Shift_Del_p.S182fs|EPN2_uc010vyo.1_Frame_Shift_Del_p.S175fs|EPN2_uc010vyp.1_Frame_Shift_Del_p.S403fs|EPN2_uc010vyq.1_Frame_Shift_Del_p.S404fs|EPN2_uc002gvh.1_Frame_Shift_Del_p.S467fs|EPN2_uc002gvj.3_Frame_Shift_Del_p.S130fs	NM_014964	NP_055779	O95208	EPN2_HUMAN	epsin 2 isoform b	467	6 X 3 AA repeats of [DE]-P-W.				endocytosis		lipid binding			skin(1)	1	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					TTCGGACTTCAAAAAAAACAG	0.393													7	325	---	---	---	---					
SUPT6H	6830	broad.mit.edu	37	17	27001303	27001305	+	In_Frame_Del	DEL	GAG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:27001303_27001305delGAG	uc002hby.2	+	3	202_204	c.112_114delGAG	c.(112-114)GAGdel	p.E43del	SUPT6H_uc010crt.2_In_Frame_Del_p.E43del	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	43	Asp/Glu-rich.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					TCTTCCAGATGAGGAGGAGGAGG	0.453													8	204	---	---	---	---					
SUPT6H	6830	broad.mit.edu	37	17	27027202	27027204	+	In_Frame_Del	DEL	AGC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:27027202_27027204delAGC	uc002hby.2	+	34	4663_4665	c.4573_4575delAGC	c.(4573-4575)AGCdel	p.S1528del	SUPT6H_uc010crt.2_In_Frame_Del_p.S1528del	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	1528	Poly-Ser.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					CATCACCCCTAGCAGCAGCAGCA	0.537													34	1012	---	---	---	---					
HOXB2	3212	broad.mit.edu	37	17	46622130	46622132	+	In_Frame_Del	DEL	AGG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:46622130_46622132delAGG	uc002inm.2	-	1	262_264	c.142_144delCCT	c.(142-144)CCTdel	p.P48del		NM_002145	NP_002136	P14652	HXB2_HUMAN	homeobox B2	48					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TTTGCTCGAAAGGAGGAGGAGGA	0.542													8	351	---	---	---	---					
BZRAP1	9256	broad.mit.edu	37	17	56387404	56387406	+	In_Frame_Del	DEL	TCC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:56387404_56387406delTCC	uc002ivx.3	-	21	4684_4686	c.3813_3815delGGA	c.(3811-3816)GAGGAA>GAA	p.1271_1272EE>E	BZRAP1_uc010dcs.2_In_Frame_Del_p.1211_1212EE>E|BZRAP1_uc010wnt.1_In_Frame_Del_p.1271_1272EE>E	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1271_1272	Poly-Glu.					mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CAGctcctcttcctcctcctcct	0.468													7	281	---	---	---	---					
FTSJ3	117246	broad.mit.edu	37	17	61899155	61899157	+	In_Frame_Del	DEL	CTC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:61899155_61899157delCTC	uc002jbz.2	-	14	1600_1602	c.1522_1524delGAG	c.(1522-1524)GAGdel	p.E508del	FTSJ3_uc002jca.2_In_Frame_Del_p.E508del	NM_017647	NP_060117	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3	508					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			ovary(1)	1						GCAGTGGATTCTCCTCCTCCTCC	0.537													9	653	---	---	---	---					
CD300A	11314	broad.mit.edu	37	17	72469708	72469709	+	Frame_Shift_Ins	INS	-	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:72469708_72469709insG	uc002jkv.2	+	2	395_396	c.74_75insG	c.(73-75)GCGfs	p.A25fs	CD300A_uc002jkw.2_Intron|CD300A_uc010dfr.2_Intron|CD300A_uc010dfs.2_Intron	NM_007261	NP_009192	Q9UGN4	CLM8_HUMAN	leukocyte membrane antigen	25	Extracellular (Potential).|Ig-like V-type.				cell adhesion	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2						AGGACCGTGGCGGGCCCCGTGG	0.569													11	522	---	---	---	---					
CD300A	11314	broad.mit.edu	37	17	72469711	72469712	+	Frame_Shift_Ins	INS	-	GC	GC			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:72469711_72469712insGC	uc002jkv.2	+	2	398_399	c.77_78insGC	c.(76-78)GGCfs	p.G26fs	CD300A_uc002jkw.2_Intron|CD300A_uc010dfr.2_Intron|CD300A_uc010dfs.2_Intron	NM_007261	NP_009192	Q9UGN4	CLM8_HUMAN	leukocyte membrane antigen	26	Extracellular (Potential).|Ig-like V-type.				cell adhesion	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2						ACCGTGGCGGGCCCCGTGGGGG	0.569													13	496	---	---	---	---					
GGA3	23163	broad.mit.edu	37	17	73239175	73239175	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:73239175delT	uc002jni.1	-	6	506	c.497delA	c.(496-498)AACfs	p.N166fs	GGA3_uc002jnj.1_Frame_Shift_Del_p.N133fs|GGA3_uc010wrw.1_Frame_Shift_Del_p.N44fs|GGA3_uc002jnk.1_Frame_Shift_Del_p.N94fs|GGA3_uc010wrx.1_Frame_Shift_Del_p.N44fs|GGA3_uc010wry.1_Frame_Shift_Del_p.N94fs|GGA3_uc010wrz.1_Intron	NM_138619	NP_619525	Q9NZ52	GGA3_HUMAN	ADP-ribosylation factor binding protein 3	166	Binds to ARF1 (in long isoform).				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|breast(1)	2			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)			AAAAACAGGGTTTTTGGGACG	0.542													8	641	---	---	---	---					
HAUS1	115106	broad.mit.edu	37	18	43685174	43685174	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr18:43685174delA	uc002lbu.2	+	2	125	c.45delA	c.(43-45)TTAfs	p.L15fs	ATP5A1_uc002lbt.1_5'Flank|HAUS1_uc002lbv.2_5'UTR	NM_138443	NP_612452	Q96CS2	HAUS1_HUMAN	coiled-coil domain containing 5	15					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				ovary(1)	1						CTGCGTGGTTAAAAAAAATAT	0.393													7	177	---	---	---	---					
CXXC1	30827	broad.mit.edu	37	18	47812275	47812277	+	In_Frame_Del	DEL	CTG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr18:47812275_47812277delCTG	uc002leq.3	-	5	1214_1216	c.481_483delCAG	c.(481-483)CAGdel	p.Q161del	CXXC1_uc002lep.3_In_Frame_Del_p.Q18del|CXXC1_uc002ler.3_In_Frame_Del_p.Q161del|CXXC1_uc010doy.2_In_Frame_Del_p.Q161del|CXXC1_uc002les.2_In_Frame_Del_p.Q161del	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	161	CXXC-type.				histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						ACCGTTTGATctgctgctgctgc	0.468													7	143	---	---	---	---					
MLLT1	4298	broad.mit.edu	37	19	6222272	6222274	+	In_Frame_Del	DEL	AGG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:6222272_6222274delAGG	uc002mek.2	-	6	1132_1134	c.968_970delCCT	c.(967-972)TCCTTC>TTC	p.S323del		NM_005934	NP_005925	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	323	Poly-Ser.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding			skin(1)	1						TTGTCCGAGAAGGAGGAGGAGGA	0.650			T	MLL	AL								7	185	---	---	---	---					
ZNF563	147837	broad.mit.edu	37	19	12430217	12430217	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:12430217delA	uc002mtp.2	-	4	860	c.622delT	c.(622-624)TGGfs	p.W208fs	ZNF563_uc002mtq.2_Intron	NM_145276	NP_660319	Q8TA94	ZN563_HUMAN	zinc finger protein 563	208	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAACTGGGCCAAAAAAAAGCT	0.393													8	504	---	---	---	---					
SFRS14	10147	broad.mit.edu	37	19	19136394	19136394	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:19136394delT	uc002nkx.2	-	3	909	c.763delA	c.(763-765)ATAfs	p.I255fs	SFRS14_uc002nkz.1_Frame_Shift_Del_p.I269fs|SFRS14_uc002nla.1_Frame_Shift_Del_p.I255fs|SFRS14_uc002nlb.2_Frame_Shift_Del_p.I255fs|SFRS14_uc010xqk.1_Intron	NM_014884	NP_055699	Q8IX01	SUGP2_HUMAN	splicing factor, arginine/serine-rich 14	255					mRNA processing|RNA splicing	nucleus	RNA binding				0			OV - Ovarian serous cystadenocarcinoma(5;3.05e-05)|Epithelial(12;0.00161)			ACGGTGGGTATTTTTTTTGTG	0.502													13	531	---	---	---	---					
HAMP	57817	broad.mit.edu	37	19	35773520	35773522	+	In_Frame_Del	DEL	CTC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:35773520_35773522delCTC	uc002nyw.2	+	1	111_113	c.40_42delCTC	c.(40-42)CTCdel	p.L18del		NM_021175	NP_066998	P81172	HEPC_HUMAN	hepcidin antimicrobial peptide preproprotein	18					defense response to bacterium|defense response to fungus|immune response|killing of cells of other organism	extracellular region	hormone activity			central_nervous_system(1)	1	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)		Epithelial(14;7.4e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.47e-19)|all cancers(14;4.17e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TTGCCTCCTGCTCCTCCTCCTCC	0.640													17	718	---	---	---	---					
DMWD	1762	broad.mit.edu	37	19	46289542	46289544	+	In_Frame_Del	DEL	CTC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:46289542_46289544delCTC	uc002pdj.1	-	3	1256_1258	c.1210_1212delGAG	c.(1210-1212)GAGdel	p.E404del	DMWD_uc002pdk.1_In_Frame_Del_p.E404del|DMWD_uc010eko.1_In_Frame_Del_p.E89del	NM_004943	NP_004934	Q09019	DMWD_HUMAN	dystrophia myotonica-containing WD repeat motif	404					meiosis						0		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		CAGCCTCGGGCTCCTCCTCCTCC	0.695													9	245	---	---	---	---					
RSPH6A	81492	broad.mit.edu	37	19	46299165	46299167	+	In_Frame_Del	DEL	CCT	-	-	rs62639328	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:46299165_46299167delCCT	uc002pdm.2	-	6	2257_2259	c.2114_2116delAGG	c.(2113-2118)GAGGGC>GGC	p.E705del	RSPH6A_uc002pdl.2_In_Frame_Del_p.E441del	NM_030785	NP_110412	Q9H0K4	RSH6A_HUMAN	radial spokehead-like 1	705	Glu-rich.					intracellular				ovary(1)|central_nervous_system(1)	2						tcctcctcgccctcctcctcctc	0.438													28	536	---	---	---	---					
NUP62	23636	broad.mit.edu	37	19	50411672	50411673	+	Frame_Shift_Ins	INS	-	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:50411672_50411673insG	uc002pqx.2	-	2	1496_1497	c.1392_1393insC	c.(1390-1395)CCCGCCfs	p.P464fs	IL4I1_uc002pqv.1_Intron|IL4I1_uc010eno.1_Intron|IL4I1_uc002pqw.1_Intron|IL4I1_uc002pqu.1_Intron|NUP62_uc002pqy.2_Frame_Shift_Ins_p.P464fs|NUP62_uc002pqz.2_Frame_Shift_Ins_p.P464fs|NUP62_uc002pra.2_Frame_Shift_Ins_p.P464fs|NUP62_uc002prb.2_Frame_Shift_Ins_p.P464fs|NUP62_uc002prc.2_Frame_Shift_Ins_p.P388fs	NM_153719	NP_714941	P37198	NUP62_HUMAN	nucleoporin 62kDa	464_465					carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding				0		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		CTGGTGTCGGCGGGGGCCCCGG	0.579													7	829	---	---	---	---					
LENG8	114823	broad.mit.edu	37	19	54963859	54963861	+	In_Frame_Del	DEL	GCA	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:54963859_54963861delGCA	uc002qfv.1	+	4	387_389	c.243_245delGCA	c.(241-246)TTGCAG>TTG	p.Q85del	LENG8_uc002qfw.2_In_Frame_Del_p.Q85del			Q96PV6	LENG8_HUMAN	RecName: Full=Leukocyte receptor cluster member 8;	85	Poly-Gln.						protein binding			central_nervous_system(1)|pancreas(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		CCTCAGCTTTGCAGCAGCAGCAG	0.532													7	522	---	---	---	---					
NLRP2	55655	broad.mit.edu	37	19	55494630	55494632	+	In_Frame_Del	DEL	GAA	-	-	rs61735083	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:55494630_55494632delGAA	uc002qij.2	+	6	1650_1652	c.1564_1566delGAA	c.(1564-1566)GAAdel	p.E523del	NLRP2_uc010yfp.1_In_Frame_Del_p.E500del|NLRP2_uc010esn.2_In_Frame_Del_p.E499del|NLRP2_uc010eso.2_In_Frame_Del_p.E520del|NLRP2_uc010esp.2_In_Frame_Del_p.E501del	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	523	NACHT.|Poly-Glu.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GAAGGAGGAGGAAGAGGATAGGG	0.567													8	322	---	---	---	---					
ZNF329	79673	broad.mit.edu	37	19	58639340	58639341	+	Frame_Shift_Ins	INS	-	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:58639340_58639341insG	uc002qrn.2	-	4	1767_1768	c.1530_1531insC	c.(1528-1533)CCCAGCfs	p.P510fs	ZNF329_uc010euk.1_RNA|ZNF329_uc002qro.1_RNA|ZNF329_uc002qrp.1_RNA	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	zinc finger protein 329	510_511	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		GGACACCGGCTGGGACCCTCCC	0.500													8	832	---	---	---	---					
ASXL2	55252	broad.mit.edu	37	2	26022304	26022306	+	In_Frame_Del	DEL	CTG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:26022304_26022306delCTG	uc002rgs.2	-	4	572_574	c.351_353delCAG	c.(349-354)AGCAGT>AGT	p.117_118SS>S		NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	117_118	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCACCATCACTGCTGCTGCTGC	0.463													17	569	---	---	---	---					
GPR113	165082	broad.mit.edu	37	2	26534413	26534413	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:26534413delC	uc002rhe.3	-	11	2183	c.2183delG	c.(2182-2184)GGTfs	p.G728fs	GPR113_uc010yky.1_Frame_Shift_Del_p.G659fs|GPR113_uc002rhb.1_Frame_Shift_Del_p.G331fs|GPR113_uc010eyk.1_Frame_Shift_Del_p.G529fs|GPR113_uc002rhc.1_Frame_Shift_Del_p.G331fs|GPR113_uc002rhd.1_RNA	NM_001145168	NP_001138640	Q8IZF5	GP113_HUMAN	G-protein coupled receptor 113 isoform 1	728	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTTGGACCAACCCCCCCTGCC	0.612													7	390	---	---	---	---					
CEBPZ	10153	broad.mit.edu	37	2	37454908	37454908	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:37454908delT	uc002rpz.2	-	2	1458	c.1428delA	c.(1426-1428)AAAfs	p.K476fs		NM_005760	NP_005751	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein zeta	476					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			pancreas(1)	1		all_hematologic(82;0.21)				ATTCAACATCTTTTTTTTTGA	0.368													8	125	---	---	---	---					
USP34	9736	broad.mit.edu	37	2	61575023	61575025	+	In_Frame_Del	DEL	TGG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:61575023_61575025delTGG	uc002sbe.2	-	15	2287_2289	c.2265_2267delCCA	c.(2263-2268)CACCAT>CAT	p.755_756HH>H		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	755_756					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			gtggtggtgatggtggtggtggt	0.281													8	265	---	---	---	---					
REV1	51455	broad.mit.edu	37	2	100055102	100055102	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:100055102delT	uc002tad.2	-	6	1386	c.1174delA	c.(1174-1176)ATGfs	p.M392fs	REV1_uc002tac.2_Frame_Shift_Del_p.M392fs|REV1_uc002tae.1_Frame_Shift_Del_p.M371fs	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	392					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			ovary(2)	2						CCTGTTTTCATTTTTTTTAAC	0.348								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					10	459	---	---	---	---					
ALS2CR11	151254	broad.mit.edu	37	2	202352352	202352352	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:202352352delT	uc002uye.2	-	15	1903	c.1855delA	c.(1855-1857)ATTfs	p.I619fs	ALS2CR11_uc002uyf.2_Frame_Shift_Del_p.I1816fs|ALS2CR11_uc010fti.2_3'UTR	NM_152525	NP_689738	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	619										large_intestine(1)|ovary(1)|skin(1)	3						CCTCTTTTAATTTTTTTTGGC	0.323													7	251	---	---	---	---					
TRPM8	79054	broad.mit.edu	37	2	234879010	234879010	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:234879010delC	uc002vvh.2	+	17	2335	c.2295delC	c.(2293-2295)CACfs	p.H765fs	TRPM8_uc010fyj.2_Intron	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	765	Helical; Name=3; (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	CGGTGCCACACCCCCCCGAGC	0.577													7	1439	---	---	---	---					
TMEM90B	79953	broad.mit.edu	37	20	24524183	24524185	+	In_Frame_Del	DEL	GGA	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr20:24524183_24524185delGGA	uc002wtw.1	+	2	1083_1085	c.450_452delGGA	c.(448-453)GTGGAG>GTG	p.E155del		NM_024893	NP_079169	Q9H7V2	SYNG1_HUMAN	transmembrane protein 90B	155	Poly-Glu.|Cytoplasmic (Potential).				response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane					0						CCTACGATGTGGAGGAGGAGGAG	0.547													9	742	---	---	---	---					
Unknown	0	broad.mit.edu	37	21	9766012	9766013	+	RNA	INS	-	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr21:9766012_9766013insA	uc011abu.1	+	8		c.509_510insA								Homo sapiens, clone IMAGE:4720764, mRNA.																		ACAACTATCAGAAAATGTATGT	0.262													4	4	---	---	---	---					
PIGP	51227	broad.mit.edu	37	21	38444815	38444815	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr21:38444815delT	uc002yvw.1	-	1	289	c.73delA	c.(73-75)ATGfs	p.M25fs	TTC3_uc002yvz.2_5'Flank|TTC3_uc011aee.1_5'Flank|PIGP_uc002yvy.1_RNA|PIGP_uc002yvx.1_Frame_Shift_Del_p.M1fs|TTC3_uc011aed.1_5'Flank|TTC3_uc010gne.1_5'Flank	NM_153681	NP_710148	P57054	PIGP_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	25					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity				0		Myeloproliferative disorder(46;0.0412)				TTTTCCACCATTTTTCCTGGG	0.488													7	869	---	---	---	---					
PLAC4	191585	broad.mit.edu	37	21	42551313	42551313	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr21:42551313delC	uc002yyz.2	-	1	5854	c.243delG	c.(241-243)TGGfs	p.W81fs	BACE2_uc002yyw.2_Intron|BACE2_uc002yyx.2_Intron|BACE2_uc002yyy.2_Intron	NM_182832	NP_878252	Q8WY50	PLAC4_HUMAN	placenta-specific 4	81											0		Prostate(19;2.29e-06)				gtgagggtatccagggtgagt	0.159													7	86	---	---	---	---					
PLAC4	191585	broad.mit.edu	37	21	42551433	42551433	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr21:42551433delG	uc002yyz.2	-	1	5734	c.123delC	c.(121-123)CCCfs	p.P41fs	BACE2_uc002yyw.2_Intron|BACE2_uc002yyx.2_Intron|BACE2_uc002yyy.2_Intron	NM_182832	NP_878252	Q8WY50	PLAC4_HUMAN	placenta-specific 4	41				P -> H (in Ref. 1; AAG23170).							0		Prostate(19;2.29e-06)				GACGGTGTCTGGGGTGAGTGA	0.517													25	139	---	---	---	---					
MYH9	4627	broad.mit.edu	37	22	36689419	36689421	+	In_Frame_Del	DEL	CCT	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr22:36689419_36689421delCCT	uc003apg.2	-	30	4280_4282	c.4049_4051delAGG	c.(4048-4053)GAGGCC>GCC	p.E1350del		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1350	Potential.			E -> EE (in Ref. 7).	actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TTGTGCTTGGCCTCCTCCTCCTC	0.650			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				7	323	---	---	---	---					
RANGAP1	5905	broad.mit.edu	37	22	41650469	41650471	+	In_Frame_Del	DEL	TCC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr22:41650469_41650471delTCC	uc003azs.2	-	10	2571_2573	c.1101_1103delGGA	c.(1099-1104)GAGGAA>GAA	p.367_368EE>E	RANGAP1_uc003azt.2_In_Frame_Del_p.367_368EE>E|RANGAP1_uc003azu.2_In_Frame_Del_p.367_368EE>E|RANGAP1_uc003azr.2_5'Flank|RANGAP1_uc010gyk.2_5'Flank|RANGAP1_uc011aoz.1_In_Frame_Del_p.312_313EE>E	NM_002883	NP_002874	P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	367_368	Asp/Glu-rich (highly acidic).|Asp/Glu-rich (highly acidic).				mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity				0						ctcttctccttcctcctcctcct	0.266													18	379	---	---	---	---					
MLC1	23209	broad.mit.edu	37	22	50506871	50506872	+	Frame_Shift_Ins	INS	-	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr22:50506871_50506872insG	uc003bjg.1	-	10	1157_1158	c.884_885insC	c.(883-885)CCAfs	p.P295fs	MLC1_uc011arl.1_Frame_Shift_Ins_p.P243fs|MLC1_uc003bjh.1_Frame_Shift_Ins_p.P295fs|MLC1_uc011arm.1_Frame_Shift_Ins_p.P265fs|MLC1_uc011arn.1_Frame_Shift_Ins_p.P216fs|MLC1_uc011aro.1_Frame_Shift_Ins_p.P261fs	NM_139202	NP_631941	Q15049	MLC1_HUMAN	megalencephalic leukoencephalopathy with	295						basolateral plasma membrane|endosome|integral to membrane|integral to membrane of membrane fraction	ion channel activity			pancreas(1)	1		all_cancers(38;7.69e-11)|all_epithelial(38;9.52e-10)|all_lung(38;3.67e-05)|Breast(42;0.000776)|Lung NSC(38;0.000946)|Ovarian(80;0.0365)|Lung SC(80;0.113)		READ - Rectum adenocarcinoma(2;0.000669)|Colorectal(2;0.00242)|LUAD - Lung adenocarcinoma(64;0.0695)|BRCA - Breast invasive adenocarcinoma(115;0.216)		CTTTTATGGCTGGCGGGTAATC	0.525													12	402	---	---	---	---					
TMEM40	55287	broad.mit.edu	37	3	12790198	12790200	+	In_Frame_Del	DEL	GAG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:12790198_12790200delGAG	uc003bxg.1	-	3	292_294	c.165_167delCTC	c.(163-168)TCCTCT>TCT	p.55_56SS>S	TMEM40_uc003bxh.1_In_Frame_Del_p.55_56SS>S|TMEM40_uc003bxi.1_Intron|TMEM40_uc011auv.1_In_Frame_Del_p.71_72SS>S	NM_018306	NP_060776	Q8WWA1	TMM40_HUMAN	transmembrane protein 40	55_56	Ser-rich.					integral to membrane					0						tgaggaggaagaggaggaggagg	0.256													7	601	---	---	---	---					
HHATL	57467	broad.mit.edu	37	3	42739670	42739672	+	In_Frame_Del	DEL	GAA	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:42739670_42739672delGAA	uc003clw.2	-	7	802_804	c.655_657delTTC	c.(655-657)TTCdel	p.F219del	HHATL_uc003clx.2_In_Frame_Del_p.F219del	NM_020707	NP_065758	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	219					negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				ovary(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.215)		TGATGGGCCCGAAGAAGAAGAAG	0.552													8	411	---	---	---	---					
CDC25A	993	broad.mit.edu	37	3	48200922	48200923	+	Frame_Shift_Del	DEL	TC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:48200922_48200923delTC	uc003csh.1	-	14	1709_1710	c.1345_1346delGA	c.(1345-1347)GATfs	p.D449fs	CDC25A_uc003csi.1_Frame_Shift_Del_p.D409fs	NM_001789	NP_001780	P30304	MPIP1_HUMAN	cell division cycle 25A isoform a	449	Rhodanese.				cell cycle checkpoint|cell division|cell proliferation|cellular response to UV|DNA replication|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding|protein tyrosine phosphatase activity			lung(3)|kidney(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000685)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		ACCCAGGCGATCTCTCTCTCTC	0.515													8	326	---	---	---	---					
USP4	7375	broad.mit.edu	37	3	49321969	49321971	+	In_Frame_Del	DEL	TCT	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:49321969_49321971delTCT	uc003cwq.2	-	18	2397_2399	c.2318_2320delAGA	c.(2317-2322)AAGACC>ACC	p.K773del	USP4_uc003cwo.2_In_Frame_Del_p.K485del|USP4_uc003cwp.2_In_Frame_Del_p.K503del|USP4_uc003cwr.2_In_Frame_Del_p.K726del	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	773					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		GCCACTGTGGTCTTCTTCTTCTT	0.532													10	424	---	---	---	---					
CACNA1D	776	broad.mit.edu	37	3	53529193	53529195	+	Translation_Start_Site	DEL	GAT	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:53529193_53529195delGAT	uc003dgv.3	+	1					CACNA1D_uc003dgu.3_Translation_Start_Site|CACNA1D_uc003dgy.3_Translation_Start_Site	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,						axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	aatgttcgtGgatgatgatgatg	0.246													13	470	---	---	---	---					
ERC2	26059	broad.mit.edu	37	3	55733470	55733472	+	In_Frame_Del	DEL	TGG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:55733470_55733472delTGG	uc003dhr.1	-	16	3037_3039	c.2781_2783delCCA	c.(2779-2784)CACCAT>CAT	p.927_928HH>H	ERC2_uc003dhq.1_RNA	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	927_928	Poly-His.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		gtggtggtgatggtggtggtggt	0.389													15	1175	---	---	---	---					
LRIG1	26018	broad.mit.edu	37	3	66436625	66436627	+	In_Frame_Del	DEL	GCT	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:66436625_66436627delGCT	uc003dmx.2	-	13	1581_1583	c.1567_1569delAGC	c.(1567-1569)AGCdel	p.S524del	SLC25A26_uc011bft.1_RNA|LRIG1_uc011bfu.1_In_Frame_Del_p.S144del|LRIG1_uc003dmw.2_In_Frame_Del_p.S190del|LRIG1_uc010hnz.2_In_Frame_Del_p.S240del|LRIG1_uc010hoa.2_In_Frame_Del_p.S548del	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	524	Extracellular (Potential).|Ig-like C2-type 1.|Poly-Ser.					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		TCATGGGGGAGCTGCTGCTGCTG	0.547													10	1206	---	---	---	---					
VGLL3	389136	broad.mit.edu	37	3	87027857	87027859	+	In_Frame_Del	DEL	CTC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:87027857_87027859delCTC	uc003dqn.2	-	2	584_586	c.220_222delGAG	c.(220-222)GAGdel	p.E74del		NM_016206	NP_057290	A8MV65	VGLL3_HUMAN	colon carcinoma related protein	74					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		GCTGGtctttctcctcctcctcc	0.394													7	128	---	---	---	---					
KIAA2018	205717	broad.mit.edu	37	3	113380090	113380090	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:113380090delT	uc003eam.2	-	7	850	c.439delA	c.(439-441)ATTfs	p.I147fs	KIAA2018_uc003eal.2_Frame_Shift_Del_p.I91fs	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	147					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						TAAACAATAATTTTTTTTTGA	0.373													8	364	---	---	---	---					
TMCC1	23023	broad.mit.edu	37	3	129370576	129370578	+	In_Frame_Del	DEL	CTG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:129370576_129370578delCTG	uc003emz.3	-	7	2209_2211	c.1708_1710delCAG	c.(1708-1710)CAGdel	p.Q570del	TMCC1_uc003emy.3_In_Frame_Del_p.Q246del|TMCC1_uc011blc.1_In_Frame_Del_p.Q391del|TMCC1_uc010htg.2_In_Frame_Del_p.Q456del	NM_001017395	NP_001017395	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	570	Potential.					integral to membrane				skin(1)	1						GCTGCACCACCTGCTGCTGCTGC	0.581													23	379	---	---	---	---					
MED12L	116931	broad.mit.edu	37	3	151148114	151148116	+	In_Frame_Del	DEL	CAG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:151148114_151148116delCAG	uc003eyp.2	+	42	6369_6371	c.6331_6333delCAG	c.(6331-6333)CAGdel	p.Q2115del	MED12L_uc011bnz.1_In_Frame_Del_p.Q1779del	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	2115	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCAGCAGACCCAGCAGCAGCAGC	0.527													10	359	---	---	---	---					
SEC62	7095	broad.mit.edu	37	3	169700663	169700664	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:169700663_169700664insA	uc003fgg.2	+	4	451_452	c.420_421insA	c.(418-423)GAGAAAfs	p.E140fs	SEC62_uc003fgh.2_Frame_Shift_Ins_p.E140fs	NM_003262	NP_003253	Q99442	SEC62_HUMAN	translocation protein 1	140_141	Cytoplasmic (Potential).				cotranslational protein targeting to membrane|transmembrane transport	aggresome|endoplasmic reticulum membrane|integral to membrane|intermediate filament cytoskeleton|rough endoplasmic reticulum	protein transporter activity|receptor activity			ovary(1)	1						aagaaaaagagaaaaaaaaaga	0.104													8	52	---	---	---	---					
FXR1	8087	broad.mit.edu	37	3	180666228	180666228	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:180666228delA	uc003fkq.2	+	5	386	c.364delA	c.(364-366)AAAfs	p.K122fs	FXR1_uc003fkp.2_Frame_Shift_Del_p.K37fs|FXR1_uc003fkr.2_Frame_Shift_Del_p.K122fs|FXR1_uc011bqj.1_Frame_Shift_Del_p.K36fs|FXR1_uc003fks.2_Frame_Shift_Del_p.K36fs|FXR1_uc011bqk.1_Frame_Shift_Del_p.K73fs|FXR1_uc011bql.1_Frame_Shift_Del_p.K109fs	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	122					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			TAAAACTGTCAAAAAAAATAC	0.333													7	272	---	---	---	---					
PDE6B	5158	broad.mit.edu	37	4	661763	661765	+	In_Frame_Del	DEL	AGG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:661763_661765delAGG	uc003gap.2	+	21	2524_2526	c.2471_2473delAGG	c.(2470-2475)AAGGAG>AAG	p.E828del	PDE6B_uc003gao.3_In_Frame_Del_p.E828del|PDE6B_uc011buy.1_In_Frame_Del_p.E549del|PDE6B_uc011buz.1_In_Frame_Del_p.E260del	NM_000283	NP_000274	P35913	PDE6B_HUMAN	phosphodiesterase 6B isoform 1	828					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0						CTGGAGGAGAAGGAGGAGGAGGA	0.562													16	513	---	---	---	---					
FGFRL1	53834	broad.mit.edu	37	4	1019055	1019056	+	Frame_Shift_Del	DEL	CA	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:1019055_1019056delCA	uc003gce.2	+	7	1596_1597	c.1435_1436delCA	c.(1435-1437)CACfs	p.H479fs	FGFRL1_uc003gcf.2_Frame_Shift_Del_p.H479fs|FGFRL1_uc003gcg.2_Frame_Shift_Del_p.H479fs|FGFRL1_uc010ibo.2_Frame_Shift_Del_p.H479fs	NM_021923	NP_068742	Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	479	His-rich.|Cytoplasmic (Potential).				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			cacagacatccacacacacaca	0.460													7	30	---	---	---	---					
CRIPAK	285464	broad.mit.edu	37	4	1388467	1388468	+	Frame_Shift_Del	DEL	CA	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:1388467_1388468delCA	uc003gdf.2	+	1	3128_3129	c.168_169delCA	c.(166-171)CTCACAfs	p.L56fs		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	56_57					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			CCCGCCTGCTCACACGTGCCCA	0.644													10	1723	---	---	---	---					
PROM1	8842	broad.mit.edu	37	4	15995680	15995680	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:15995680delT	uc003goo.2	-	15	1909	c.1697delA	c.(1696-1698)AATfs	p.N566fs	PROM1_uc003gor.2_Frame_Shift_Del_p.N566fs|PROM1_uc003gos.2_Frame_Shift_Del_p.N557fs|PROM1_uc003got.2_Frame_Shift_Del_p.N566fs|PROM1_uc003gou.2_Frame_Shift_Del_p.N557fs|PROM1_uc003gop.2_Frame_Shift_Del_p.N557fs|PROM1_uc003goq.3_Frame_Shift_Del_p.N557fs	NM_006017	NP_006008	O43490	PROM1_HUMAN	prominin 1 isoform 1	566	Extracellular (Potential).				camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	7						AGTGCCTCTATTTTTTTTGCA	0.428													7	372	---	---	---	---					
ANTXR2	118429	broad.mit.edu	37	4	80905990	80905990	+	Frame_Shift_Del	DEL	C	-	-	rs12647691	by1000genomes	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:80905990delC	uc003hlz.3	-	13	1832	c.1069delG	c.(1069-1071)GCCfs	p.A357fs	ANTXR2_uc003hly.3_Frame_Shift_Del_p.A357fs|ANTXR2_uc003hlx.1_RNA|ANTXR2_uc010ijn.2_Frame_Shift_Del_p.A254fs	NM_001145794	NP_001139266	P58335	ANTR2_HUMAN	anthrax toxin receptor 2 isoform 2	357	Poly-Pro.|Cytoplasmic (Potential).					endoplasmic reticulum membrane|extracellular region|integral to membrane|plasma membrane	metal ion binding|protein binding|receptor activity			ovary(1)	1						GGTGCAGGGGCGGGTGGTGGT	0.348									Juvenile_Hyaline_Fibromatosis				8	72	---	---	---	---					
ADAD1	132612	broad.mit.edu	37	4	123302211	123302211	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:123302211delA	uc003ieo.2	+	4	469	c.237delA	c.(235-237)CCAfs	p.P79fs	ADAD1_uc003iep.2_Frame_Shift_Del_p.P79fs|ADAD1_uc003ieq.2_Frame_Shift_Del_p.P61fs	NM_139243	NP_640336	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1	79					multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0						TCCTTCCTCCAAAAAAAATAC	0.358													8	274	---	---	---	---					
HMGB2	3148	broad.mit.edu	37	4	174253277	174253279	+	In_Frame_Del	DEL	TCC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:174253277_174253279delTCC	uc011ckc.1	-	4	702_704	c.582_584delGGA	c.(580-585)GAGGAA>GAA	p.194_195EE>E	HMGB2_uc003ita.3_In_Frame_Del_p.194_195EE>E|HMGB2_uc003itb.2_In_Frame_Del_p.194_195EE>E|HMGB2_uc003itc.2_3'UTR	NM_001130689	NP_001124161	P26583	HMGB2_HUMAN	high-mobility group box 2	194_195	Asp/Glu-rich (acidic).				base-excision repair, DNA ligation|cell chemotaxis|cellular response to lipopolysaccharide|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|negative regulation of transcription, DNA-dependent|nucleosome assembly|phosphatidylinositol-mediated signaling|positive regulation of DNA binding|positive regulation of endothelial cell proliferation|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|positive regulation of nuclease activity|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	condensed chromosome|extracellular space|nucleolus|nucleoplasm|perinuclear region of cytoplasm|protein complex	chemoattractant activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding|transcription regulatory region DNA binding				0		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;9.58e-18)|Epithelial(43;3.75e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.24e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		atcttcttcttcctcctcctcct	0.286													8	322	---	---	---	---					
THBS4	7060	broad.mit.edu	37	5	79372774	79372776	+	In_Frame_Del	DEL	TGA	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr5:79372774_79372776delTGA	uc003kgh.2	+	17	2312_2314	c.1989_1991delTGA	c.(1987-1992)TGTGAT>TGT	p.D668del	uc003kgi.3_Intron	NM_003248	NP_003239	P35443	TSP4_HUMAN	thrombospondin 4 precursor	668	TSP type-3 7.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity				0		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		GTGACGAGTGTGATGATGATGAT	0.562													13	978	---	---	---	---					
AP3S1	1176	broad.mit.edu	37	5	115202418	115202421	+	Frame_Shift_Del	DEL	AAGA	-	-	rs80118146		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr5:115202418_115202421delAAGA	uc003krl.2	+	2	237_240	c.121_124delAAGA	c.(121-126)AAGAGAfs	p.K41fs	AP3S1_uc003krk.2_Frame_Shift_Del_p.K19fs|AP3S1_uc003krm.2_Frame_Shift_Del_p.K41fs	NM_001284	NP_001275	Q92572	AP3S1_HUMAN	adaptor-related protein complex 3, sigma 1	41_42					insulin receptor signaling pathway|intracellular protein transport|vesicle-mediated transport	AP-type membrane coat adaptor complex|cytoplasmic vesicle membrane|Golgi apparatus|transport vesicle	protein binding|protein transporter activity				0		all_cancers(142;0.00377)|all_epithelial(76;0.000129)|Prostate(80;0.0132)|Ovarian(225;0.0776)|Lung NSC(810;0.245)		OV - Ovarian serous cystadenocarcinoma(64;1.08e-07)|Epithelial(69;1.11e-06)|all cancers(49;5.2e-05)		TTTGGTATCTAAGAGAGATGAAAA	0.304													11	258	---	---	---	---					
MEGF10	84466	broad.mit.edu	37	5	126792989	126792991	+	In_Frame_Del	DEL	CAG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr5:126792989_126792991delCAG	uc003kuh.3	+	26	3764_3766	c.3402_3404delCAG	c.(3400-3405)AACAGC>AAC	p.S1139del	MEGF10_uc003kui.3_In_Frame_Del_p.S1139del	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	1139	Cytoplasmic (Potential).|Necessary for formation of large intracellular vacuoles.|Ser-rich.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		gcagcagcaacagcagcagcagc	0.433													7	217	---	---	---	---					
CDC25C	995	broad.mit.edu	37	5	137627690	137627690	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr5:137627690delT	uc003lcp.1	-	8	1002	c.731delA	c.(730-732)AAGfs	p.K244fs	CDC25C_uc003lcq.1_Frame_Shift_Del_p.K171fs|CDC25C_uc003lcr.1_Frame_Shift_Del_p.K244fs|CDC25C_uc011cyp.1_Frame_Shift_Del_p.K261fs|CDC25C_uc003lcs.1_Frame_Shift_Del_p.K322fs	NM_001790	NP_001781	P30307	MPIP3_HUMAN	cell division cycle 25C isoform a	244					cell cycle checkpoint|cell division|cell proliferation|DNA replication|G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm	protein tyrosine phosphatase activity|WW domain binding			lung(3)	3			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			AGAAAAATACTTTTTTTTAAC	0.388													7	381	---	---	---	---					
HMMR	3161	broad.mit.edu	37	5	162917425	162917426	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr5:162917425_162917426insA	uc003lzf.2	+	17	2171_2172	c.1989_1990insA	c.(1987-1992)GCTAAAfs	p.A663fs	HMMR_uc003lzh.2_Frame_Shift_Ins_p.A664fs|HMMR_uc003lzg.2_Frame_Shift_Ins_p.A648fs|HMMR_uc011dem.1_Frame_Shift_Ins_p.A577fs|uc003lzi.2_Intron	NM_012484	NP_036616	O75330	HMMR_HUMAN	hyaluronan-mediated motility receptor isoform b	663_664	Hyaluronic acid-binding (Potential).					cell surface|cytoplasm	hyaluronic acid binding				0	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0296)|OV - Ovarian serous cystadenocarcinoma(192;0.0423)|Epithelial(171;0.0848)		GTCAGCTTGCTAAAAAAAAACA	0.307													10	295	---	---	---	---					
CANX	821	broad.mit.edu	37	5	179149920	179149920	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr5:179149920delT	uc003mkk.2	+	11	1475	c.1298delT	c.(1297-1299)ATTfs	p.I433fs	CANX_uc011dgp.1_Frame_Shift_Del_p.I468fs|CANX_uc003mkl.2_Frame_Shift_Del_p.I433fs|CANX_uc011dgq.1_Frame_Shift_Del_p.I325fs	NM_001746	NP_001737	P27824	CALX_HUMAN	calnexin precursor	433	Lumenal (Potential).			SDI -> LTF (in Ref. 9; AAA35696).	post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein secretion	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane|melanosome	calcium ion binding|sugar binding|unfolded protein binding				0	all_cancers(89;0.000129)|all_epithelial(37;5.59e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0413)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACCTCTGACATTTTTTTTGAC	0.423													7	369	---	---	---	---					
BTN2A2	10385	broad.mit.edu	37	6	26384091	26384093	+	In_Frame_Del	DEL	CCT	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:26384091_26384093delCCT	uc003nhq.2	+	2	128_130	c.42_44delCCT	c.(40-45)TCCCTC>TCC	p.L24del	BTN2A2_uc011dkf.1_In_Frame_Del_p.L24del|BTN2A2_uc011dkg.1_In_Frame_Del_p.L24del|BTN2A2_uc003nhr.2_In_Frame_Del_p.L24del|BTN2A2_uc011dkh.1_In_Frame_Del_p.L24del|BTN2A2_uc003nhs.2_In_Frame_Del_p.L24del|BTN2A2_uc003nht.2_In_Frame_Del_p.L24del	NM_006995	NP_008926	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2 isoform a	24					negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane					0						TGCCAGCCTCcctcctcctcctc	0.483													9	374	---	---	---	---					
TULP1	7287	broad.mit.edu	37	6	35478775	35478777	+	In_Frame_Del	DEL	TCC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:35478775_35478777delTCC	uc003okv.3	-	5	372_374	c.360_362delGGA	c.(358-363)GAGGAA>GAA	p.120_121EE>E	TULP1_uc003okw.3_In_Frame_Del_p.67_68EE>E	NM_003322	NP_003313	O00294	TULP1_HUMAN	tubby like protein 1	120_121	Poly-Glu.		Missing (in RP14).		dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			ovary(2)|central_nervous_system(1)	3						gtcctcctcttcctcctcctcct	0.389													7	454	---	---	---	---					
MDFI	4188	broad.mit.edu	37	6	41621169	41621171	+	In_Frame_Del	DEL	CTG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:41621169_41621171delCTG	uc003oqp.3	+	6	926_928	c.597_599delCTG	c.(595-600)CTCTGC>CTC	p.C204del	MDFI_uc003oqq.3_In_Frame_Del_p.C204del|MDFI_uc010jxn.2_In_Frame_Del_p.C204del	NM_005586	NP_005577	Q99750	MDFI_HUMAN	MyoD family inhibitor	204	Cys-rich.				cytoplasmic sequestering of transcription factor|dorsal/ventral axis specification|negative regulation of DNA binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of Wnt receptor signaling pathway	cytoplasm|nucleus					0	Ovarian(28;0.0327)|Colorectal(47;0.121)		Colorectal(64;0.0123)|COAD - Colon adenocarcinoma(64;0.0264)|KIRC - Kidney renal clear cell carcinoma(1;0.138)			ACTCGTGCCTCTGCTGCTGCTGC	0.655													15	395	---	---	---	---					
UBR2	23304	broad.mit.edu	37	6	42611951	42611951	+	Splice_Site	DEL	G	-	-	rs112519289		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:42611951delG	uc011dur.1	+	19	2098	c.2098_splice	c.e19-1	p.T700_splice	UBR2_uc011dus.1_Splice_Site_p.T345_splice|UBR2_uc010jxv.1_Splice_Site_p.T204_splice|UBR2_uc003osh.2_Splice_Site	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin						cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			AAAAAAAAAAGACAGGTGTCT	0.373													7	329	---	---	---	---					
HCRTR2	3062	broad.mit.edu	37	6	55039411	55039411	+	Frame_Shift_Del	DEL	C	-	-	rs76774128		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:55039411delC	uc003pcl.2	+	1	341	c.26delC	c.(25-27)TCCfs	p.S9fs	HCRTR2_uc010jzv.2_RNA|HCRTR2_uc010jzu.1_RNA	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	9	Extracellular (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TTGGAGGACTCCCCCCCTTGT	0.567													7	585	---	---	---	---					
C6orf165	154313	broad.mit.edu	37	6	88144700	88144700	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:88144700delA	uc003plv.2	+	11	1515	c.1423delA	c.(1423-1425)AAAfs	p.K475fs	SLC35A1_uc003plx.2_5'Flank|C6orf165_uc003plw.2_Frame_Shift_Del_p.K287fs|C6orf165_uc010kbv.1_RNA|C6orf165_uc003plu.1_Frame_Shift_Del_p.K475fs	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	475										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		AGAAAAGGCCAAAAAAAATAC	0.269													10	349	---	---	---	---					
MDN1	23195	broad.mit.edu	37	6	90432675	90432675	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:90432675delT	uc003pnn.1	-	40	6082	c.5966delA	c.(5965-5967)AAGfs	p.K1989fs		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	1989					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GAAACTCACCTTTTTTTTGTC	0.403													12	699	---	---	---	---					
FYN	2534	broad.mit.edu	37	6	111983042	111983042	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:111983042delT	uc003pvj.2	-	13	1854	c.1514delA	c.(1513-1515)AAGfs	p.K505fs	FYN_uc003pvi.2_Frame_Shift_Del_p.K450fs|FYN_uc003pvk.2_Frame_Shift_Del_p.K505fs|FYN_uc003pvh.2_Frame_Shift_Del_p.K502fs	NM_002037	NP_002028	P06241	FYN_HUMAN	protein-tyrosine kinase fyn isoform a	505	Protein kinase.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|central_nervous_system(1)|skin(1)	7		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	TTCAGGGTCCTTTTTCCAGCA	0.562													9	885	---	---	---	---					
C7orf44	55744	broad.mit.edu	37	7	43679188	43679188	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:43679188delT	uc003tin.1	-	6	528	c.434delA	c.(433-435)AAGfs	p.K145fs	C7orf44_uc003til.2_RNA|C7orf44_uc003tii.2_RNA|C7orf44_uc003tij.2_RNA|C7orf44_uc010kxu.1_RNA|C7orf44_uc003tik.2_RNA|C7orf44_uc003tim.1_RNA|C7orf44_uc003tio.1_Frame_Shift_Del_p.K145fs|C7orf44_uc003tiq.1_Frame_Shift_Del_p.K145fs|C7orf44_uc003tip.1_Frame_Shift_Del_p.K145fs	NM_018224	NP_060694	Q9GZY4	CG044_HUMAN	hypothetical protein LOC55744	145						integral to membrane				ovary(1)	1						TCTCTACTCCTTTTTCACTTC	0.517													7	518	---	---	---	---					
STYXL1	51657	broad.mit.edu	37	7	75651194	75651196	+	In_Frame_Del	DEL	ATC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:75651194_75651196delATC	uc003uej.3	-	4	453_455	c.280_282delGAT	c.(280-282)GATdel	p.D94del	STYXL1_uc011kgf.1_In_Frame_Del_p.M4del|STYXL1_uc011kgg.1_5'UTR|STYXL1_uc003ueh.2_In_Frame_Del_p.M4del|STYXL1_uc003uek.3_Intron|STYXL1_uc003uel.2_In_Frame_Del_p.D94del|STYXL1_uc003uem.2_In_Frame_Del_p.D94del|STYXL1_uc010ldg.1_RNA|STYXL1_uc010ldh.1_In_Frame_Del_p.D94del|STYXL1_uc003uen.1_In_Frame_Del_p.D94del	NM_016086	NP_057170	Q9Y6J8	STYL1_HUMAN	map kinase phosphatase-like protein MK-STYX	94	Rhodanese.				intracellular signal transduction|protein dephosphorylation	intracellular	protein binding|protein tyrosine/serine/threonine phosphatase activity				0						CAGAGTCTGAATCATCATCATCA	0.389													7	1271	---	---	---	---					
ABCB4	5244	broad.mit.edu	37	7	87074281	87074282	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:87074281_87074282insA	uc003uiv.1	-	10	1091_1092	c.1015_1016insT	c.(1015-1017)TCAfs	p.S339fs	ABCB4_uc003uiw.1_Frame_Shift_Ins_p.S339fs|ABCB4_uc003uix.1_Frame_Shift_Ins_p.S339fs	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	339	Helical; (By similarity).|ABC transmembrane type-1 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					AATTAGGATTGAAAAAAAAACC	0.347													8	149	---	---	---	---					
GIGYF1	64599	broad.mit.edu	37	7	100284335	100284337	+	In_Frame_Del	DEL	CCT	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:100284335_100284337delCCT	uc003uwg.1	-	7	1638_1640	c.629_631delAGG	c.(628-633)GAGGGC>GGC	p.E210del		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	210	Poly-Glu.									large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					CTCCAGCTGCcctcctcctcctc	0.616													7	135	---	---	---	---					
SRRT	51593	broad.mit.edu	37	7	100482040	100482042	+	In_Frame_Del	DEL	AGG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:100482040_100482042delAGG	uc003uwy.2	+	8	1077_1079	c.809_811delAGG	c.(808-813)CAGGAG>CAG	p.E275del	SRRT_uc010lhl.1_In_Frame_Del_p.E275del|SRRT_uc003uxa.2_In_Frame_Del_p.E275del|SRRT_uc003uwz.2_In_Frame_Del_p.E275del	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	275	Glu-rich.				cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						ATCCTGGAGCAGGAGGAGGAGGA	0.596													8	86	---	---	---	---					
DNAJC2	27000	broad.mit.edu	37	7	102964992	102964992	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:102964992delT	uc003vbo.2	-	6	841	c.590delA	c.(589-591)AATfs	p.N197fs	PMPCB_uc011kll.1_Intron|DNAJC2_uc003vbn.2_Translation_Start_Site|DNAJC2_uc010lix.2_Frame_Shift_Del_p.N197fs|DNAJC2_uc003vbp.2_Translation_Start_Site|DNAJC2_uc003vbq.1_RNA	NM_014377	NP_055192	Q99543	DNJC2_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 2	197	ZRF1-UBD.				'de novo' cotranslational protein folding|chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane	chromatin binding|DNA binding|histone binding|Hsp70 protein binding|ubiquitin binding			kidney(1)	1						TTTAGGAACATTTTTTTTATT	0.234													7	403	---	---	---	---					
LUC7L2	51631	broad.mit.edu	37	7	139094365	139094366	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:139094365_139094366delAG	uc003vux.2	+	7	1118_1119	c.744_745delAG	c.(742-747)GAAGAGfs	p.E248fs	LUC7L2_uc011kqs.1_Frame_Shift_Del_p.E245fs|LUC7L2_uc011kqt.1_Frame_Shift_Del_p.E314fs|LUC7L2_uc003vuy.2_Frame_Shift_Del_p.E247fs|LUC7L2_uc003vuz.1_Frame_Shift_Del_p.E195fs|LUC7L2_uc003vva.2_Frame_Shift_Del_p.E195fs	NM_016019	NP_057103	Q9Y383	LC7L2_HUMAN	LUC7-like 2	248_249	Arg/Ser-rich.						enzyme binding|metal ion binding				0	Melanoma(164;0.242)					AACGAAGAGAAGAGAGAGAGAG	0.391													8	123	---	---	---	---					
MLL3	58508	broad.mit.edu	37	7	151874013	151874013	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:151874013delT	uc003wla.2	-	38	8744	c.8525delA	c.(8524-8526)AATfs	p.N2842fs	MLL3_uc003wkz.2_Frame_Shift_Del_p.N1903fs|MLL3_uc003wky.2_Frame_Shift_Del_p.N351fs	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2842					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ATTCTCATCATTTTTTTCAGT	0.378			N		medulloblastoma								8	512	---	---	---	---					
MCPH1	79648	broad.mit.edu	37	8	6289099	6289099	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:6289099delA	uc003wqi.2	+	4	381	c.313delA	c.(313-315)AAAfs	p.K105fs	MCPH1_uc003wqh.2_Frame_Shift_Del_p.K105fs|MCPH1_uc011kwl.1_Frame_Shift_Del_p.K105fs	NM_024596	NP_078872	Q8NEM0	MCPH1_HUMAN	microcephalin	105						microtubule organizing center				central_nervous_system(1)|skin(1)	2		Hepatocellular(245;0.0663)		Colorectal(4;0.0505)		AAGCCTAATTAAAAAAAAAGT	0.274													8	328	---	---	---	---					
DLC1	10395	broad.mit.edu	37	8	12957611	12957613	+	In_Frame_Del	DEL	GCT	-	-	rs137989738		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:12957611_12957613delGCT	uc003wwm.2	-	9	2677_2679	c.2233_2235delAGC	c.(2233-2235)AGCdel	p.S745del	DLC1_uc003wwk.1_In_Frame_Del_p.S308del|DLC1_uc003wwl.1_In_Frame_Del_p.S342del|DLC1_uc011kxx.1_In_Frame_Del_p.S234del	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	745	Poly-Ser.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						TCTCCGACTGGCTGCTGCTGCTG	0.621													8	221	---	---	---	---					
WRN	7486	broad.mit.edu	37	8	30945377	30945379	+	In_Frame_Del	DEL	AAG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:30945377_30945379delAAG	uc003xio.3	+	12	2305_2307	c.1517_1519delAAG	c.(1516-1521)AAAGAA>AAA	p.E510del	WRN_uc011lbe.1_In_Frame_Del_p.E38del|WRN_uc010lvk.2_5'UTR	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	510	Poly-Glu.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		CTTCCTACTAaagaagaagaaga	0.266			Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				12	253	---	---	---	---					
STAU2	27067	broad.mit.edu	37	8	74507471	74507471	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:74507471delT	uc003xzm.2	-	11	1327	c.1091delA	c.(1090-1092)AATfs	p.N364fs	STAU2_uc011lfg.1_Frame_Shift_Del_p.N192fs|STAU2_uc003xzn.2_Frame_Shift_Del_p.N332fs|STAU2_uc011lfh.1_Frame_Shift_Del_p.N260fs|STAU2_uc003xzo.2_Frame_Shift_Del_p.N364fs|STAU2_uc003xzp.2_Frame_Shift_Del_p.N332fs|STAU2_uc011lfi.1_Frame_Shift_Del_p.N326fs|STAU2_uc003xzq.2_Frame_Shift_Del_p.N144fs|STAU2_uc010lzk.2_Frame_Shift_Del_p.N332fs|STAU2_uc010lzl.1_Frame_Shift_Del_p.N192fs	NM_014393	NP_055208	Q9NUL3	STAU2_HUMAN	staufen homolog 2 isoform e	364	DRBM 4.				transport	endoplasmic reticulum|microtubule|nucleolus	double-stranded RNA binding				0	Breast(64;0.0138)		Epithelial(68;0.026)|BRCA - Breast invasive adenocarcinoma(89;0.0483)|all cancers(69;0.0972)			TTCTGCAGCATTTTTTTTGGC	0.328													7	419	---	---	---	---					
DPYS	1807	broad.mit.edu	37	8	105440214	105440214	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:105440214delT	uc003yly.3	-	6	1215	c.1086delA	c.(1084-1086)AAAfs	p.K362fs		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	362					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CCACCACGCCTTTTTCCCATA	0.478													9	1015	---	---	---	---					
ATAD2	29028	broad.mit.edu	37	8	124368685	124368685	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:124368685delA	uc003yqh.3	-	13	1698	c.1590delT	c.(1588-1590)TTTfs	p.F530fs	ATAD2_uc011lii.1_Frame_Shift_Del_p.F321fs|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Frame_Shift_Del_p.F530fs	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	530					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			CAATTTCGTCAAAAAAAATAA	0.413													8	147	---	---	---	---					
EIF2C2	27161	broad.mit.edu	37	8	141554345	141554345	+	Frame_Shift_Del	DEL	G	-	-	rs148575703	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:141554345delG	uc003yvn.2	-	14	1846	c.1806delC	c.(1804-1806)CCCfs	p.P602fs	EIF2C2_uc010men.2_Frame_Shift_Del_p.P525fs|EIF2C2_uc010meo.2_Frame_Shift_Del_p.P602fs	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	602	Piwi.				mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			CATCCCCGGCGGGGGGGTGAG	0.647													9	750	---	---	---	---					
TSNARE1	203062	broad.mit.edu	37	8	143310866	143310868	+	In_Frame_Del	DEL	GAT	-	-	rs142964918		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:143310866_143310868delGAT	uc003ywk.2	-	13	1637_1639	c.1519_1521delATC	c.(1519-1521)ATCdel	p.I507del	TSNARE1_uc011lju.1_In_Frame_Del_p.I506del|TSNARE1_uc003ywj.2_In_Frame_Del_p.I508del	NM_145003	NP_659440	Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	507	Poly-Ile.|Helical; (Potential).				vesicle-mediated transport	integral to membrane					0	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CAGAGGTGGCGATGATGATGATG	0.414													11	373	---	---	---	---					
ZC3H3	23144	broad.mit.edu	37	8	144522387	144522389	+	In_Frame_Del	DEL	GAG	-	-	rs2272754	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:144522387_144522389delGAG	uc003yyd.2	-	11	2666_2668	c.2637_2639delCTC	c.(2635-2640)TCCTCA>TCA	p.879_880SS>S		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	879_880	Poly-Ser.				mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding	p.S879F(1)		skin(1)	1	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			Gggaggggatgaggaggaggagg	0.552													7	57	---	---	---	---					
FOXD4	2298	broad.mit.edu	37	9	117406	117407	+	Frame_Shift_Ins	INS	-	G	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:117406_117407insG	uc003zfz.2	-	1	1011_1012	c.713_714insC	c.(712-714)CCGfs	p.P238fs		NM_207305	NP_997188	Q12950	FOXD4_HUMAN	forkhead box D4	238	Pro-rich.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		CTGGCTGCGGCGGGGCAGGGGC	0.743													7	177	---	---	---	---					
VCP	7415	broad.mit.edu	37	9	35062983	35062985	+	In_Frame_Del	DEL	AAG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:35062983_35062985delAAG	uc003zvy.2	-	7	1190_1192	c.801_803delCTT	c.(799-804)TTCTTG>TTG	p.F267del	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_5'UTR|VCP_uc010mki.1_In_Frame_Del_p.F222del	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	267					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			ACCATTGATCAAGAAGAAGAAGG	0.463													8	634	---	---	---	---					
FKBP15	23307	broad.mit.edu	37	9	115969556	115969556	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:115969556delT	uc004bgs.2	-	3	308	c.190delA	c.(190-192)ACAfs	p.T64fs	FKBP15_uc010muu.1_Frame_Shift_Del_p.T128fs|FKBP15_uc011lxd.1_5'UTR|FKBP15_uc010mut.1_Intron|FKBP15_uc004bgt.2_Frame_Shift_Del_p.T64fs	NM_015258	NP_056073	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	64					endocytosis|protein folding	axon|early endosome	actin binding			ovary(3)	3						GCTGGTGCTGTTTTTGGTGTT	0.378													7	1131	---	---	---	---					
DAB2IP	153090	broad.mit.edu	37	9	124522389	124522391	+	In_Frame_Del	DEL	AAG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:124522389_124522391delAAG	uc004bln.2	+	6	826_828	c.757_759delAAG	c.(757-759)AAGdel	p.K257del	DAB2IP_uc004blo.2_In_Frame_Del_p.K161del	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	285	C2.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2						GGAGACCGACAAGAAGAAGAAGA	0.601													17	295	---	---	---	---					
CRAT	1384	broad.mit.edu	37	9	131864814	131864814	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:131864814delC	uc004bxh.2	-	5	777	c.495delG	c.(493-495)GGGfs	p.G165fs	CRAT_uc004bxg.2_Frame_Shift_Del_p.G144fs|CRAT_uc004bxk.3_Frame_Shift_Del_p.G144fs	NM_000755	NP_000746	P43155	CACP_HUMAN	carnitine acetyltransferase precursor	165					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA oxidase|transport	endoplasmic reticulum|mitochondrial inner membrane|peroxisomal matrix	carnitine O-acetyltransferase activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)	L-Carnitine(DB00583)	ACAGTGGCTTCCCCCCCAGGT	0.607													8	1459	---	---	---	---					
CEL	1056	broad.mit.edu	37	9	135941982	135941982	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:135941982delG	uc010naa.1	+	5	629	c.613delG	c.(613-615)GGGfs	p.G205fs		NM_001807	NP_001798	P19835	CEL_HUMAN	carboxyl ester lipase precursor	202					cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		CGCGGCCTTCGGGGGGGACCC	0.642													9	768	---	---	---	---					
GRIN1	2902	broad.mit.edu	37	9	140056884	140056886	+	In_Frame_Del	DEL	GAG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:140056884_140056886delGAG	uc004clk.2	+	13	2110_2112	c.1780_1782delGAG	c.(1780-1782)GAGdel	p.E598del	GRIN1_uc004cli.1_In_Frame_Del_p.E273del|GRIN1_uc004clj.1_In_Frame_Del_p.E595del|GRIN1_uc004cll.2_In_Frame_Del_p.E598del|GRIN1_uc004clm.2_In_Frame_Del_p.E598del|GRIN1_uc004cln.2_In_Frame_Del_p.E616del|GRIN1_uc004clo.2_In_Frame_Del_p.E616del	NM_007327	NP_015566	Q05586	NMDZ1_HUMAN	NMDA receptor 1 isoform NR1-3 precursor	598	Cytoplasmic (Potential).				ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			skin(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	GGTGAACAGCGAGGAGGAGGAGG	0.739													12	185	---	---	---	---					
RBM10	8241	broad.mit.edu	37	X	47030586	47030588	+	In_Frame_Del	DEL	GAG	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chrX:47030586_47030588delGAG	uc004dhf.2	+	4	740_742	c.361_363delGAG	c.(361-363)GAGdel	p.E125del	RBM10_uc004dhe.1_In_Frame_Del_p.E115del|RBM10_uc004dhg.2_Intron|RBM10_uc004dhh.2_In_Frame_Del_p.E125del|RBM10_uc010nhq.2_Intron|RBM10_uc004dhi.2_In_Frame_Del_p.E190del	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	125	Poly-Glu.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						ggaggaggatgaggaggaggagg	0.527													7	39	---	---	---	---					
NAP1L3	4675	broad.mit.edu	37	X	92928153	92928155	+	In_Frame_Del	DEL	TGC	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chrX:92928153_92928155delTGC	uc004efq.2	-	1	454_456	c.149_151delGCA	c.(148-153)AGCACT>ACT	p.S50del	FAM133A_uc004efr.1_5'Flank	NM_004538	NP_004529	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	50	Ser-rich.				nucleosome assembly	chromatin assembly complex				ovary(1)|skin(1)	2						ctgccactagtgctgctgctgct	0.217													7	44	---	---	---	---					
PASD1	139135	broad.mit.edu	37	X	150817142	150817144	+	In_Frame_Del	DEL	GCT	-	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chrX:150817142_150817144delGCT	uc004fev.3	+	9	1017_1019	c.685_687delGCT	c.(685-687)GCTdel	p.A236del		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	236	Poly-Ala.					nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CGTTGAACCCgctgctgctgctg	0.355													7	271	---	---	---	---					
UTY	7404	broad.mit.edu	37	Y	15448217	15448218	+	Splice_Site	INS	-	A	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chrY:15448217_15448218insA	uc004fsx.1	-	16	2776	c.1771_splice	c.e16-1	p.G591_splice	UTY_uc004fsw.1_Splice_Site_p.G254_splice|UTY_uc010nwx.1_Intron|UTY_uc004fsy.2_Splice_Site_p.G591_splice|UTY_uc004fsz.2_Splice_Site_p.G591_splice	NM_007125	NP_009056	O14607	UTY_HUMAN	tetratricopeptide repeat protein isoform 3						chromatin modification	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						ATGAAGCCCCTAAAAAAAAAAA	0.361													14	63	---	---	---	---					
