Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
Unknown	0	broad.mit.edu	37	1	148882025	148882025	+	RNA	SNP	C	T	T	rs150449871	by1000genomes	TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr1:148882025C>T	uc009wkv.1	+	3		c.246C>T								Homo sapiens cDNA, FLJ17483.																		TGTTTTCTAGCAGTGACAAAT	0.343000													9	256					0	0	0.069234	0	0
LRRN2	10446	broad.mit.edu	37	1	204587730	204587730	+	Missense_Mutation	SNP	C	T	T			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr1:204587730C>T	uc001hbe.1	-	3	1779	c.1391G>A	c.(1390-1392)CGA>CAA	p.R464Q	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Missense_Mutation_p.R464Q|LRRN2_uc009xbf.1_Missense_Mutation_p.R464Q|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	464	Ig-like C2-type.|Extracellular (Potential).				cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			AGGTGTCAGTCGAAGCCCAGC	0.637000													10	130					0	0	0.080935	0	0
BEND7	222389	broad.mit.edu	37	10	13534699	13534699	+	Missense_Mutation	SNP	A	T	T			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr10:13534699A>T	uc001imm.2	-	5	890	c.593T>A	c.(592-594)CTA>CAA	p.L198Q	BEND7_uc001imo.3_Missense_Mutation_p.L211Q	NM_152751	NP_689964	Q8N7W2	BEND7_HUMAN	BEN domain containing 7 isoform 1	250							protein binding			ovary(1)|breast(1)	2						GAGAGCAGATAGCTCAGAGGC	0.522000													29	451					0	0	0.050027	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	Missense_Mutation	SNP	A	G	G	rs2257765		TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr10:38654432A>G	uc010qex.1	+	5	599	c.524A>G	c.(523-525)AAT>AGT	p.N175S	HSD17B7P2_uc001izq.2_RNA|HSD17B7P2_uc001izo.1_RNA|HSD17B7P2_uc001izp.1_Missense_Mutation_p.N173S					SubName: Full=cDNA FLJ60462, highly similar to 3-keto-steroid reductase (EC 1.1.1.270);												0						TCATCTCGCAATGCAAGGAAA	0.453000													7	147					0	0	0.029380	0	0
SLC29A3	55315	broad.mit.edu	37	10	73115969	73115969	+	Missense_Mutation	SNP	T	C	C			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr10:73115969T>C	uc001jrr.3	+	5	799	c.742T>C	c.(742-744)TAC>CAC	p.Y248H	SLC29A3_uc001jrs.3_Missense_Mutation_p.Y248H|SLC29A3_uc010qjq.1_Missense_Mutation_p.Y102H|SLC29A3_uc001jrt.3_Missense_Mutation_p.Y42H|SLC29A3_uc001jru.3_Missense_Mutation_p.Y60H	NM_018344	NP_060814	Q9BZD2	S29A3_HUMAN	solute carrier family 29 (nucleoside	248	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|late endosome membrane|lysosomal membrane	nucleoside transmembrane transporter activity				0						CATGGGACTCTACCTGCTGCT	0.557000													8	195					0	0	0.038147	0	0
BTAF1	9044	broad.mit.edu	37	10	93711219	93711219	+	Missense_Mutation	SNP	G	C	C			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr10:93711219G>C	uc001khr.2	+	5	558	c.460G>C	c.(460-462)GGC>CGC	p.G154R	BTAF1_uc009xua.1_RNA	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	154					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				GAAGAAACTTGGCCTTAATAT	0.363000													15	227					0	0	0.119110	0	0
MRVI1	10335	broad.mit.edu	37	11	10597887	10597887	+	Nonsense_Mutation	SNP	C	A	A			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr11:10597887C>A	uc010rcc.1	-	21	3117	c.2731G>T	c.(2731-2733)GAG>TAG	p.E911*	uc001miu.2_Intron|MRVI1_uc001miw.2_Nonsense_Mutation_p.E902*|MRVI1_uc010rcb.1_Nonsense_Mutation_p.E903*|MRVI1_uc009ygb.1_Nonsense_Mutation_p.E596*|MRVI1_uc001mix.2_Nonsense_Mutation_p.E596*|MRVI1_uc001miz.2_Nonsense_Mutation_p.E820*|MRVI1_uc009ygc.1_Nonsense_Mutation_p.E820*|MRVI1_uc010rcd.1_Nonsense_Mutation_p.E705*|MRVI1_uc009ygd.1_Nonsense_Mutation_p.E596*	NM_001100167	NP_001093637	Q9Y6F6	MRVI1_HUMAN	JAW1-related protein isoform c	884					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				ovary(2)|central_nervous_system(1)	3				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		TCCTACTGCTCTGTAGGCTGC	0.577000													9	97					2.17888e-05	2.26059e-05	0.058154	1	0
SPTBN2	6712	broad.mit.edu	37	11	66468444	66468444	+	Missense_Mutation	SNP	C	G	G			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr11:66468444C>G	uc001ojd.2	-	16	3198	c.3126G>C	c.(3124-3126)GAG>GAC	p.E1042D		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1042	Spectrin 7.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CGGTCTGCACCTCTCTCAGCC	0.692000													18	116					0	0	0.049695	0	0
LRP5	4041	broad.mit.edu	37	11	68190978	68190978	+	Missense_Mutation	SNP	A	T	T			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr11:68190978A>T	uc001ont.2	+	14	3124	c.3049A>T	c.(3049-3051)AGC>TGC	p.S1017C	LRP5_uc009ysg.2_Missense_Mutation_p.S427C	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	1017	Beta-propeller 4.|LDL-receptor class B 16.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						GACCTCTCTGAGCCAAGGCCA	0.587000													52	345					0	0	0.139131	0	0
GAB2	9846	broad.mit.edu	37	11	77937956	77937956	+	Silent	SNP	C	T	T			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr11:77937956C>T	uc001ozh.2	-	4	762	c.762G>A	c.(760-762)CCG>CCA	p.P254P	GAB2_uc001ozg.2_Silent_p.P216P	NM_080491	NP_536739	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2 isoform a	254					osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity			ovary(5)|lung(1)	6	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			TGTGCCGGCTCGGCTTGGGAA	0.572000													9	176					0	0	0.058154	0	0
ELMOD1	55531	broad.mit.edu	37	11	107535878	107535878	+	Silent	SNP	G	A	A			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr11:107535878G>A	uc010rvs.1	+	12	1364	c.960G>A	c.(958-960)GCG>GCA	p.A320A	ELMOD1_uc001pjm.2_Silent_p.A312A|ELMOD1_uc010rvt.1_Silent_p.A314A	NM_018712	NP_061182	Q8N336	ELMD1_HUMAN	ELMO/CED-12 domain containing 1 isoform 1	320					phagocytosis	cytoskeleton	GTPase activator activity				0		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00304)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Epithelial(105;0.00027)|all cancers(92;0.00481)		CAGACATGGCGCTGTGCCCAC	0.478000													73	387					0	0	0.139131	0	0
KRAS	3845	broad.mit.edu	37	12	25380275	25380275	+	Missense_Mutation	SNP	T	G	G	rs17851045		TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr12:25380275T>G	uc001rgp.1	-	3	364	c.183A>C	c.(181-183)CAA>CAC	p.Q61H	KRAS_uc001rgq.1_Missense_Mutation_p.Q61H	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	61	GTP.		Q -> R (in a colorectal cancer sample; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.Q61H(140)|p.Q61L(51)|p.Q61R(44)|p.Q61K(24)|p.Q61P(11)|p.Q61E(10)|p.Q61D(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			TGTACTCCTCTTGACCTGCTG	0.423000	Q61H(T3M4_PANCREAS)|Q61H(HS766T_PANCREAS)|Q61H(NCIH460_LUNG)|Q61H(NCIH1155_LUNG)|Q61H(CL11_LARGE_INTESTINE)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			19	178					0	0	0.038395	0	0
GEFT	115557	broad.mit.edu	37	12	58010135	58010135	+	Missense_Mutation	SNP	C	T	T			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr12:58010135C>T	uc001spb.2	+	14	1949	c.1489C>T	c.(1489-1491)CCT>TCT	p.P497S	GEFT_uc009zpy.2_Missense_Mutation_p.P536S|GEFT_uc001spa.2_Missense_Mutation_p.P391S|uc001spc.2_Intron|GEFT_uc001spd.2_Missense_Mutation_p.P202S	NM_182947	NP_891992	Q86VW2	ARHGP_HUMAN	RhoA/RAC/CDC42 exchange factor isoform 1	497					regulation of Rho protein signal transduction	cytosol|plasma membrane|sarcomere	Rho guanyl-nucleotide exchange factor activity				0	Melanoma(17;0.122)					GCCAAGAGGGCCTGGAGTGGG	0.592000													29	188					0	0	0.134883	0	0
MYH6	4624	broad.mit.edu	37	14	23870014	23870014	+	Missense_Mutation	SNP	G	C	C			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr14:23870014G>C	uc001wjv.2	-	13	1381	c.1314C>G	c.(1312-1314)AAC>AAG	p.N438K	MYH6_uc010akp.1_Missense_Mutation_p.N438K	NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	438	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TCACCATCCAGTTGAACATCT	0.562000													16	232					0	0	0.038395	0	0
DDHD1	80821	broad.mit.edu	37	14	53558534	53558534	+	Missense_Mutation	SNP	C	T	T			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr14:53558534C>T	uc001xai.2	-	4	1488	c.1258G>A	c.(1258-1260)GAC>AAC	p.D420N	DDHD1_uc001xaj.2_Missense_Mutation_p.D427N|DDHD1_uc001xah.2_Missense_Mutation_p.D420N|DDHD1_uc001xag.2_Missense_Mutation_p.D2N	NM_001160148	NP_001153620	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1 isoform c	420					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			ovary(2)	2	Breast(41;0.037)					CTTCCTTGGTCCATTTTCTGC	0.363000													45	266					0	0	0.124865	0	0
C15orf59	388135	broad.mit.edu	37	15	74032751	74032751	+	Missense_Mutation	SNP	G	A	A			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr15:74032751G>A	uc002avy.2	-	2	734	c.389C>T	c.(388-390)TCG>TTG	p.S130L		NM_001039614	NP_001034703	Q2T9L4	CO059_HUMAN	hypothetical protein LOC388135	130										pancreas(1)	1						TGGCCGAGTCGACTCGGGACC	0.627000													43	281					0	0	0.124865	0	0
GOLGA6L10	647042	broad.mit.edu	37	15	82635117	82635117	+	RNA	SNP	T	C	C			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr15:82635117T>C	uc002bgx.2	-	5		c.463A>G						A6NI86	GG6LA_HUMAN	Homo sapiens cDNA FLJ40113 fis, clone TESTI2008621.												0						TTTTTCAATTTCTTGACCCGC	0.383000													6	27					0	0	0.093190	0	0
SRCAP	10847	broad.mit.edu	37	16	30749733	30749733	+	Missense_Mutation	SNP	C	T	T			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr16:30749733C>T	uc002dze.1	+	34	8757	c.8372C>T	c.(8371-8373)CCG>CTG	p.P2791L	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.P2586L	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2791	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CCGGGAAGCCCGTCTGTCCGC	0.662000													13	206					0	0	0.105934	0	0
NFAT5	10725	broad.mit.edu	37	16	69689654	69689654	+	Missense_Mutation	SNP	C	T	T			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr16:69689654C>T	uc002exm.1	+	5	2302	c.1094C>T	c.(1093-1095)ACT>ATT	p.T365I	NFAT5_uc002exh.1_Missense_Mutation_p.T159I|NFAT5_uc002exi.2_Missense_Mutation_p.T289I|NFAT5_uc002exj.1_Missense_Mutation_p.T289I|NFAT5_uc002exk.1_Missense_Mutation_p.T289I|NFAT5_uc002exl.1_Missense_Mutation_p.T383I|NFAT5_uc002exn.1_Missense_Mutation_p.T383I	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	365	RHD.				excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						ATTGAAGGCACTACTGTTATA	0.423000													15	222					0	0	0.146539	0	0
TP53	7157	broad.mit.edu	37	17	7579311	7579311	+	Splice_Site	SNP	C	T	T			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr17:7579311C>T	uc002gim.2	-	4	569	c.375_splice	c.e4+1	p.T125_splice	TP53_uc002gig.1_Splice_Site_p.T125_splice|TP53_uc002gih.2_Splice_Site_p.T125_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Splice_Site_p.T125_splice|TP53_uc010cni.1_Splice_Site_p.T125_splice|TP53_uc002gij.2_Splice_Site_p.T125_splice|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Splice_Site_p.T86_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(11)|p.0?(7)|p.V73fs*9(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGCAACTGACCGTGCAAGTC	0.532000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			28	219					0	0	0.144211	0	0
TTC19	54902	broad.mit.edu	37	17	15909860	15909860	+	Silent	SNP	A	G	G			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr17:15909860A>G	uc002gph.1	+	7	1035	c.1017A>G	c.(1015-1017)GAA>GAG	p.E339E	TTC19_uc010cox.1_RNA	NM_017775	NP_060245	Q6DKK2	TTC19_HUMAN	tetratricopeptide repeat domain 19	218					cell cycle|cytokinesis|mitochondrial respiratory chain complex III assembly	centrosome|midbody|mitochondrial inner membrane	protein binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		GAGAAAAGGAATTAGCAGAAG	0.363000													30	207					0	0	0.050027	0	0
CACNB1	782	broad.mit.edu	37	17	37334238	37334238	+	Missense_Mutation	SNP	G	T	T	rs143114489		TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr17:37334238G>T	uc002hrm.1	-	12	1298	c.1145C>A	c.(1144-1146)CCT>CAT	p.P382H	CACNB1_uc002hrl.1_Missense_Mutation_p.P154H|CACNB1_uc002hrn.2_Missense_Mutation_p.P382H|CACNB1_uc002hro.2_Missense_Mutation_p.P427H	NM_000723	NP_000714	Q02641	CACB1_HUMAN	calcium channel, voltage-dependent, beta 1	382					axon guidance	voltage-gated calcium channel complex				large_intestine(1)|ovary(1)	2					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	GGCACTCACAGGGGGGCACTG	0.537000													33	306					2.09667e-21	2.32031e-21	0.064281	1	0
AZU1	566	broad.mit.edu	37	19	830841	830841	+	Missense_Mutation	SNP	G	A	A	rs61732996	byFrequency	TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr19:830841G>A	uc002lpz.1	+	4	510	c.494G>A	c.(493-495)CGT>CAT	p.R165H		NM_001700	NP_001691	P20160	CAP7_HUMAN	azurocidin 1 preproprotein	165	Peptidase S1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cellular extravasation|defense response to Gram-negative bacterium|glial cell migration|induction of positive chemotaxis|inflammatory response|macrophage chemotaxis|microglial cell activation|monocyte activation|positive regulation of cell adhesion|positive regulation of fractalkine biosynthetic process|positive regulation of interleukin-1 beta biosynthetic process|positive regulation of MHC class II biosynthetic process|positive regulation of phagocytosis|positive regulation of tumor necrosis factor biosynthetic process|proteolysis|regulation of vascular permeability	azurophil granule|extracellular region	heparin binding|serine-type endopeptidase activity|toxin binding			pancreas(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGTCTCTCCCGTTTTCCCAGG	0.657000													6	115					0	0	0.029380	0	0
MIDN	90007	broad.mit.edu	37	19	1257115	1257115	+	Missense_Mutation	SNP	C	A	A			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr19:1257115C>A	uc002lrp.2	+	8	1766	c.1251C>A	c.(1249-1251)CAC>CAA	p.H417Q		NM_177401	NP_796375	Q504T8	MIDN_HUMAN	midnolin	417						nucleolus					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTCCGTACCACTGGTCACCCA	0.706000													9	111					0.000274275	0.000281047	0.047766	1	0
ZNRF4	148066	broad.mit.edu	37	19	5455852	5455852	+	Missense_Mutation	SNP	C	T	T			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr19:5455852C>T	uc002mca.3	+	1	427	c.350C>T	c.(349-351)CCG>CTG	p.P117L		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	117	Extracellular (Potential).					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GCGGATCTGCCGGCGCTGTTC	0.672000													8	230					0	0	0.047766	0	0
ZNF653	115950	broad.mit.edu	37	19	11596575	11596575	+	Missense_Mutation	SNP	T	C	C			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr19:11596575T>C	uc002mrz.1	-	7	1519	c.1466A>G	c.(1465-1467)AAT>AGT	p.N489S		NM_138783	NP_620138	Q96CK0	ZN653_HUMAN	zinc finger protein 653	489	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATGCACAAGATTGACGTGGTT	0.562000													33	256					0	0	0.059317	0	0
LOC284441	284441	broad.mit.edu	37	19	20369296	20369296	+	Missense_Mutation	SNP	C	T	T			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr19:20369296C>T	uc002nov.2	+	1	840	c.89C>T	c.(88-90)ACG>ATG	p.T30M		NR_003128				SubName: Full=cDNA FLJ51655, highly similar to Actin-like protein 2;												0						TGGGATGACACGAAACACCTG	0.378000													51	457					0	0	0.139131	0	0
RPS11	6205	broad.mit.edu	37	19	50000840	50000840	+	Missense_Mutation	SNP	C	T	T			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr19:50000840C>T	uc002pob.1	+	3	291	c.211C>T	c.(211-213)CGG>TGG	p.R71W	SNORD35B_uc002poc.2_5'Flank	NM_001015	NP_001006	P62280	RS11_HUMAN	ribosomal protein S11	71					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|rRNA binding|structural constituent of ribosome				0		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00206)|GBM - Glioblastoma multiforme(486;0.0245)		CATTCGAGGGCGGATCCTCTC	0.537000													33	272					0	0	0.045705	0	0
ZNF534	147658	broad.mit.edu	37	19	52942411	52942411	+	Silent	SNP	G	A	A	rs113700997		TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr19:52942411G>A	uc002pzk.2	+	4	1798	c.1737G>A	c.(1735-1737)GCG>GCA	p.A579A	ZNF534_uc002pzj.1_Intron|ZNF534_uc010epo.1_Intron|ZNF534_uc002pzl.2_Silent_p.A566A	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	579	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CACACCTTGCGCGACATAGGA	0.443000													5	53					0	0	0.021553	0	0
COLEC11	78989	broad.mit.edu	37	2	3691377	3691377	+	Missense_Mutation	SNP	G	A	A			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr2:3691377G>A	uc002qya.2	+	7	633	c.485G>A	c.(484-486)CGC>CAC	p.R162H	COLEC11_uc002qxz.2_Missense_Mutation_p.R159H|COLEC11_uc002qyb.2_Missense_Mutation_p.R138H|COLEC11_uc002qyc.2_Missense_Mutation_p.R138H|COLEC11_uc010ewo.2_Missense_Mutation_p.R114H|COLEC11_uc010ewp.2_Missense_Mutation_p.R136H|COLEC11_uc010ewq.2_Missense_Mutation_p.R112H|COLEC11_uc010ewr.2_Missense_Mutation_p.R112H|COLEC11_uc010ews.2_Missense_Mutation_p.R88H	NM_024027	NP_076932	Q9BWP8	COL11_HUMAN	collectin sub-family member 11 isoform a	162	C-type lectin.					collagen	mannose binding				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.127)		GAGGAGAAGCGCTACGCGGAC	0.637000													8	145					0	0	0.047766	0	0
BIN1	274	broad.mit.edu	37	2	127806138	127806138	+	Silent	SNP	G	A	A			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr2:127806138G>A	uc002tns.1	-	19	2091	c.1746C>T	c.(1744-1746)GGC>GGT	p.G582G	BIN1_uc010yzf.1_Silent_p.G374G|BIN1_uc010yzg.1_Silent_p.G459G|BIN1_uc002tnu.1_Silent_p.G413G|BIN1_uc002toa.1_Silent_p.G471G|BIN1_uc002tnt.1_Silent_p.G398G|BIN1_uc002tnv.1_Silent_p.G539G|BIN1_uc002tnw.1_Silent_p.G486G|BIN1_uc002tnx.1_Silent_p.G443G|BIN1_uc002tny.1_Silent_p.G495G|BIN1_uc002tnz.1_Silent_p.G507G|BIN1_uc002tob.1_Silent_p.G428G|BIN1_uc002toc.1_Silent_p.G464G	NM_139343	NP_647593	O00499	BIN1_HUMAN	bridging integrator 1 isoform 1	582	SH3.				cell proliferation|endocytosis|interspecies interaction between organisms|multicellular organismal development	actin cytoskeleton|nucleus				ovary(2)|central_nervous_system(2)|skin(2)|lung(1)	7	Colorectal(110;0.0831)			BRCA - Breast invasive adenocarcinoma(221;0.073)		CGGGGAAGACGCCACGGCACT	0.622000													15	213					0	0	0.038395	0	0
CHGB	1114	broad.mit.edu	37	20	5903661	5903661	+	Missense_Mutation	SNP	G	A	A			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr20:5903661G>A	uc002wmg.2	+	4	1177	c.871G>A	c.(871-873)GAC>AAC	p.D291N	CHGB_uc010zqz.1_5'UTR	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	291						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						GAGCAGGCCCGACAGGTCCTC	0.582000													4	61					0	0	0.009096	0	0
SHQ1	55164	broad.mit.edu	37	3	72893552	72893552	+	Missense_Mutation	SNP	C	T	T			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr3:72893552C>T	uc003dpf.2	-	2	273	c.166G>A	c.(166-168)GTA>ATA	p.V56I	SHQ1_uc010hod.2_5'UTR	NM_018130	NP_060600	Q6PI26	SHQ1_HUMAN	SHQ1 homolog	56	CS.				ribonucleoprotein complex assembly	cytosol|nucleoplasm	protein binding			ovary(2)|large_intestine(1)	3		Prostate(10;0.00482)|Lung NSC(201;0.0339)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;9.68e-05)|Epithelial(33;0.000563)|LUSC - Lung squamous cell carcinoma(21;0.00229)|Lung(16;0.00688)|KIRC - Kidney renal clear cell carcinoma(39;0.018)|Kidney(39;0.0213)		CCATTTTCTACAATTCTTCCA	0.333000													11	168					0	0	0.080935	0	0
PIK3R4	30849	broad.mit.edu	37	3	130452457	130452457	+	Missense_Mutation	SNP	T	A	A			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr3:130452457T>A	uc003enj.2	-	4	1966	c.1385A>T	c.(1384-1386)TAC>TTC	p.Y462F		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	462	HEAT 2.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						TGGCAGAATGTATTCCGGATA	0.438000													32	249					0	0	0.054565	0	0
IGSF10	285313	broad.mit.edu	37	3	151164707	151164707	+	Missense_Mutation	SNP	C	T	T	rs35114212	byFrequency	TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr3:151164707C>T	uc011bod.1	-	4	3062	c.3062G>A	c.(3061-3063)CGG>CAG	p.R1021Q		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1021					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCTGATAATCCGCCCCCTTCC	0.473000													18	245					0	0	0.055883	0	0
BCHE	590	broad.mit.edu	37	3	165548002	165548002	+	Missense_Mutation	SNP	A	C	C			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr3:165548002A>C	uc003fem.3	-	2	980	c.820T>G	c.(820-822)TTA>GTA	p.L274V	BCHE_uc003fen.3_Intron	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	274					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	AATTTAGCTAAGTTCAACGTT	0.388000													45	312					0	0	0.117977	0	0
PDGFRA	5156	broad.mit.edu	37	4	55152040	55152040	+	Silent	SNP	C	T	T	rs2228230	byFrequency	TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr4:55152040C>T	uc003han.3	+	18	2803	c.2472C>T	c.(2470-2472)GTC>GTT	p.V824V	PDGFRA_uc003haa.2_Silent_p.V584V	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	824	Protein kinase.|Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity	p.V824V(8)|p.V824L(1)		soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CTCGCAACGTCCTCCTGGCAC	0.498000			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			12	390					0	0	0.093190	0	0
FAT4	79633	broad.mit.edu	37	4	126412333	126412333	+	Missense_Mutation	SNP	G	A	A	rs138173652		TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr4:126412333G>A	uc003ifj.3	+	17	14356	c.14356G>A	c.(14356-14358)GGA>AGA	p.G4786R	FAT4_uc011cgp.1_Missense_Mutation_p.G3027R|FAT4_uc003ifi.1_Missense_Mutation_p.G2263R	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4786	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TCCTCCAGTCGGACTTTCTAT	0.527000													22	223					0	0	0.069288	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140720422	140720422	+	Silent	SNP	G	A	A			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr5:140720422G>A	uc003ljk.1	+	1	2069	c.1884G>A	c.(1882-1884)ACG>ACA	p.T628T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Silent_p.T628T	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	628	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGTGCGCACGGCGCGAGCCC	0.682000													11	267					0	0	0.080935	0	0
HIST1H2BJ	8970	broad.mit.edu	37	6	27100336	27100336	+	Missense_Mutation	SNP	G	A	A			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr6:27100336G>A	uc003niv.2	-	1	240	c.194C>T	c.(193-195)TCG>TTG	p.S65L	HIST1H2BJ_uc003niu.1_RNA|HIST1H2AG_uc003niw.2_5'Flank	NM_021058	NP_066402	P06899	H2B1J_HUMAN	histone cluster 1, H2bj	65					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0						GTTCACAAACGAATTCATGAT	0.562000													31	539					0	0	0.144211	0	0
SAMD5	389432	broad.mit.edu	37	6	147830216	147830216	+	Missense_Mutation	SNP	A	C	C			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr6:147830216A>C	uc003qmc.1	+	1	154	c.152A>C	c.(151-153)CAC>CCC	p.H51P		NM_001030060	NP_001025231	Q5TGI4	SAMD5_HUMAN	sterile alpha motif domain containing 5	51	SAM.										0		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;9.55e-10)|GBM - Glioblastoma multiforme(68;0.112)		GCGCCCGCGCACCGCCGCCGT	0.637000													10	41					0	0	0.091800	0	0
CYP7A1	1581	broad.mit.edu	37	8	59404129	59404129	+	Missense_Mutation	SNP	C	G	G			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr8:59404129C>G	uc003xtm.3	-	6	1483	c.1420G>C	c.(1420-1422)GCT>CCT	p.A474P		NM_000780	NP_000771	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A,	474					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				GGACATTTAGCTTGGCCCTCT	0.388000									Neonatal_Giant_Cell_Hepatitis				19	182					0	0	0.038395	0	0
SDCBP	6386	broad.mit.edu	37	8	59490601	59490601	+	Missense_Mutation	SNP	G	T	T			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr8:59490601G>T	uc003xtn.2	+	6	562	c.412G>T	c.(412-414)GTT>TTT	p.V138F	SDCBP_uc003xto.2_Missense_Mutation_p.V137F|SDCBP_uc003xtr.2_Missense_Mutation_p.V137F|SDCBP_uc003xtp.2_Missense_Mutation_p.V132F|SDCBP_uc003xtq.2_Missense_Mutation_p.V138F|SDCBP_uc003xts.2_Missense_Mutation_p.V144F|SDCBP_uc011led.1_Intron	NM_005625	NP_005616	O00560	SDCB1_HUMAN	syntenin isoform 1	138	PDZ 1.				actin cytoskeleton organization|axon guidance|positive regulation of phosphorylation|protein targeting to membrane|substrate-dependent cell migration, cell extension|synaptic transmission	cytoskeleton|cytosol|endoplasmic reticulum membrane|focal adhesion|interleukin-5 receptor complex|melanosome|nucleus	cytoskeletal adaptor activity|frizzled binding|interleukin-5 receptor binding|protein heterodimerization activity|protein N-terminus binding|syndecan binding				0		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				GGGTATATTTGTTCAGCTAGT	0.378000													22	187					6.44725e-10	6.86054e-10	0.069288	1	0
Unknown	0	broad.mit.edu	37	9	68413572	68413573	+	RNA	DNP	CG	TC	TC			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr9:68413572_68413573CG>TC	uc004aex.2	+	1		c.127_128CG>TC								Homo sapiens mRNA; cDNA DKFZp564N0763 (from clone DKFZp564N0763).																		CCAGTGGCGCCGGATCTAGGAA	0.569000													3	12					0	0	0.115264	0	0
NLGN4X	57502	broad.mit.edu	37	X	5821413	5821413	+	Missense_Mutation	SNP	G	A	A			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chrX:5821413G>A	uc010ndh.2	-	5	1807	c.1306C>T	c.(1306-1308)CGG>TGG	p.R436W	NLGN4X_uc004crp.2_Missense_Mutation_p.R456W|NLGN4X_uc004crq.2_Missense_Mutation_p.R436W|NLGN4X_uc010ndi.2_Missense_Mutation_p.R473W|NLGN4X_uc004crr.2_Missense_Mutation_p.R436W|NLGN4X_uc010ndj.2_Missense_Mutation_p.R436W	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	436	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						GTTTTCCGCCGCGTCTCCGGG	0.602000													14	131					0	0	0.069288	0	0
ZC3H12B	340554	broad.mit.edu	37	X	64719038	64719038	+	Missense_Mutation	SNP	A	T	T			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chrX:64719038A>T	uc010nko.2	+	3	884	c.875A>T	c.(874-876)GAC>GTC	p.D292V		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	292							endonuclease activity|nucleic acid binding|zinc ion binding			lung(1)|kidney(1)|pancreas(1)	3						AACTACCGAGACCTTCAAGTT	0.433000													27	252					0	0	0.091800	0	0
NLGN3	54413	broad.mit.edu	37	X	70367880	70367880	+	Missense_Mutation	SNP	C	T	T			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chrX:70367880C>T	uc004dzd.1	+	1	481	c.281C>T	c.(280-282)TCG>TTG	p.S94L	NLGN3_uc010nlb.1_Missense_Mutation_p.S94L|NLGN3_uc004dzb.2_Missense_Mutation_p.S94L|NLGN3_uc004dzc.2_Intron|NLGN3_uc011mps.1_Missense_Mutation_p.S94L|NLGN3_uc011mpr.1_Missense_Mutation_p.S94L	NM_018977	NP_061850	Q9NZ94	NLGN3_HUMAN	neuroligin 3	94	Extracellular (Potential).				neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			ovary(1)	1	Renal(35;0.156)					CCATCCTGGTCGGGCATCCGG	0.632000													9	138					0	0	0.069234	0	0
Unknown	0	broad.mit.edu	37	X	80185266	80185266	+	Missense_Mutation	SNP	G	T	T	rs5959744	by1000genomes	TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chrX:80185266G>T	uc004eec.1	+	1	339	c.165G>T	c.(163-165)CAG>CAT	p.Q55H						SubName: Full=cDNA FLJ16670 fis, clone THYMU3001133, highly similar to Voltage-dependent anion-selective channel protein 1; SubName: Full=Voltage-dependent anion channel 1, isoform CRA_a;																		TGGAAGATCAGCTTGCACGTG	0.453000													8	233					5.68852e-11	6.13179e-11	0.047766	1	0
TMCO2	127391	broad.mit.edu	37	1	40713708	40713709	+	Frame_Shift_Del	DEL	TC	-	-			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr1:40713708_40713709delTC	uc001cfe.2	+	1	136_137	c.43_44delTC	c.(43-45)TCTfs	p.S15fs		NM_001008740	NP_001008740	Q7Z6W1	TMCO2_HUMAN	transmembrane and coiled-coil domains 2	15						integral to membrane				ovary(1)	1	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			CCTCTTAGAGTCTCTCTCTCTC	0.406													9	625	---	---	---	---					
C1orf125	126859	broad.mit.edu	37	1	179337955	179337955	+	Frame_Shift_Del	DEL	A	-	-			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr1:179337955delA	uc001gmo.2	+	3	245	c.118delA	c.(118-120)AAAfs	p.K40fs	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmn.1_Intron|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Frame_Shift_Del_p.K40fs	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	40											0						GCTAAAGGAGAAAAAAAATAT	0.378													7	218	---	---	---	---					
MICALCL	84953	broad.mit.edu	37	11	12316384	12316389	+	In_Frame_Del	DEL	CTCCTA	-	-	rs3812754	byFrequency	TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr11:12316384_12316389delCTCCTA	uc001mkg.1	+	3	1697_1702	c.1406_1411delCTCCTA	c.(1405-1413)CCTCCTACA>CCA	p.PT470del		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	470_471					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)		cctcctcctcctcctACAGCGGGAGG	0.432													8	23	---	---	---	---					
MBD6	114785	broad.mit.edu	37	12	57919302	57919302	+	Frame_Shift_Del	DEL	T	-	-			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr12:57919302delT	uc001soj.1	+	6	775	c.551delT	c.(550-552)CTTfs	p.L184fs	MBD6_uc001sok.1_Frame_Shift_Del_p.L51fs|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	184	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						CCTGGGGGGCTTTTCCCCCCA	0.637													7	528	---	---	---	---					
MLEC	9761	broad.mit.edu	37	12	121134166	121134168	+	In_Frame_Del	DEL	GAA	-	-			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr12:121134166_121134168delGAA	uc001tyy.1	+	5	848_850	c.697_699delGAA	c.(697-699)GAAdel	p.E238del		NM_014730	NP_055545	Q14165	MLEC_HUMAN	malectin precursor	238	Poly-Glu.|Lumenal (Potential).				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	carbohydrate binding			ovary(1)	1						gaaagaagaggaagaagaagaag	0.404													8	615	---	---	---	---					
HSPH1	10808	broad.mit.edu	37	13	31715381	31715382	+	Frame_Shift_Ins	INS	-	T	T			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr13:31715381_31715382insT	uc001utj.2	-	13	2129_2130	c.1731_1732insA	c.(1729-1734)AAAGTTfs	p.K577fs	HSPH1_uc001utk.2_Frame_Shift_Ins_p.K533fs|HSPH1_uc010aaw.2_Frame_Shift_Ins_p.K536fs|HSPH1_uc001utl.2_Frame_Shift_Ins_p.K579fs|HSPH1_uc010tds.1_Frame_Shift_Ins_p.K501fs	NM_006644	NP_006635	Q92598	HS105_HUMAN	heat shock 105kD	577_578					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding				0		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		GGCTGGTCAACTTTTTTTTCAT	0.376													8	359	---	---	---	---					
NOB1	28987	broad.mit.edu	37	16	69782978	69782980	+	In_Frame_Del	DEL	TCC	-	-			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr16:69782978_69782980delTCC	uc002exs.2	-	6	583_585	c.567_569delGGA	c.(565-570)GAGGAA>GAA	p.189_190EE>E		NM_014062	NP_054781	Q9ULX3	NOB1_HUMAN	nin one binding protein	189_190	Poly-Glu.					nucleus	metal ion binding|protein binding				0						CCCGTTTTCTTCCTCCTCCTCCT	0.522													10	372	---	---	---	---					
ZFHX3	463	broad.mit.edu	37	16	72991713	72991715	+	In_Frame_Del	DEL	CCA	-	-	rs4788682	by1000genomes	TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr16:72991713_72991715delCCA	uc002fck.2	-	2	3003_3005	c.2330_2332delTGG	c.(2329-2334)GTGGCT>GCT	p.V777del	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	777	Poly-Ala.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				gccgccgcagccaccgccgccgc	0.458													7	181	---	---	---	---					
Unknown	0	broad.mit.edu	37	16	90160897	90160898	+	In_Frame_Ins	INS	-	GCG	GCG			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr16:90160897_90160898insGCG	uc002fqp.2	+	2	848_849	c.370_371insGCG	c.(370-372)CGC>CGCGGC	p.125_126insG	uc002fqq.2_Intron					Homo sapiens, Similar to tubulin, beta, 2, clone IMAGE:4873024, mRNA.																		CTCCTGGGAACGCGGCCCTCCC	0.728													18	48	---	---	---	---					
LOC100130581	100130581	broad.mit.edu	37	17	41466121	41466131	+	RNA	DEL	CGGCGCATGGA	-	-	rs66825422		TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr17:41466121_41466131delCGGCGCATGGA	uc010wib.1	-	1		c.136_146delTCCATGCGCCG			LOC100130581_uc010wic.1_RNA|LOC100130581_uc010czf.2_RNA|LOC100130581_uc010wid.1_RNA|LOC100130581_uc010wie.1_RNA	NR_027412				Homo sapiens cDNA FLJ41591 fis, clone CTONG2022153.												0						CAGAGGGAGGCGGCGCATGGACGGCGAGGGC	0.649													3	4	---	---	---	---					
TSHZ3	57616	broad.mit.edu	37	19	31769141	31769142	+	Frame_Shift_Ins	INS	-	C	C			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr19:31769141_31769142insC	uc002nsy.3	-	2	1622_1623	c.1557_1558insG	c.(1555-1560)GGGCTTfs	p.G519fs		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	519_520					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					AGGATATCAAGCCCCCCCTTGG	0.500													9	663	---	---	---	---					
TMEM131	23505	broad.mit.edu	37	2	98427639	98427639	+	Frame_Shift_Del	DEL	T	-	-			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr2:98427639delT	uc002syh.3	-	18	2149	c.1920delA	c.(1918-1920)AAAfs	p.K640fs		NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	640						integral to membrane				ovary(4)|central_nervous_system(2)	6						TCCCCTCTAATTTTTTTGCAG	0.393													8	835	---	---	---	---					
GCC2	9648	broad.mit.edu	37	2	109087914	109087914	+	Frame_Shift_Del	DEL	T	-	-			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr2:109087914delT	uc002tec.2	+	6	2283	c.2129delT	c.(2128-2130)GTTfs	p.V710fs	GCC2_uc002ted.2_Frame_Shift_Del_p.V609fs	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	710	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						GATTTGGAGGTTTTTTTGTCT	0.299													8	836	---	---	---	---					
RANBP2	5903	broad.mit.edu	37	2	109382805	109382805	+	Frame_Shift_Del	DEL	T	-	-			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr2:109382805delT	uc002tem.3	+	20	5936	c.5810delT	c.(5809-5811)ATTfs	p.I1937fs		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	1937					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						CGTGGTGTGATTTTTGGCCAA	0.413													7	922	---	---	---	---					
RBM45	129831	broad.mit.edu	37	2	178988920	178988920	+	Frame_Shift_Del	DEL	A	-	-			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr2:178988920delA	uc002ulv.2	+	8	1227	c.1135delA	c.(1135-1137)AAAfs	p.K379fs		NM_152945	NP_694453	Q8IUH3	RBM45_HUMAN	RNA binding motif protein 45	381					cell differentiation|nervous system development	cytoplasm|nucleus	nucleotide binding|RNA binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.00957)|all cancers(119;0.037)			TCCATCATGCAAAAAAAAAGC	0.353													8	274	---	---	---	---					
C21orf99	149992	broad.mit.edu	37	21	14439225	14439226	+	RNA	INS	-	A	A			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr21:14439225_14439226insA	uc002yja.3	+	10		c.2743_2744insA				NR_026916				Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						TATATTAAATGAAAAATTAGGG	0.287													9	124	---	---	---	---					
DHX36	170506	broad.mit.edu	37	3	154032977	154032978	+	Frame_Shift_Ins	INS	-	T	T			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr3:154032977_154032978insT	uc003ezy.3	-	3	541_542	c.460_461insA	c.(460-462)ATGfs	p.M154fs	DHX36_uc010hvq.2_Frame_Shift_Ins_p.M154fs|DHX36_uc003ezz.3_Frame_Shift_Ins_p.M154fs	NM_020865	NP_065916	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	154	Potential.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GATTCTAAACATTTTTTTTTCT	0.337													7	199	---	---	---	---					
CRIPAK	285464	broad.mit.edu	37	4	1388530	1388531	+	Frame_Shift_Ins	INS	-	CA	CA			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr4:1388530_1388531insCA	uc003gdf.2	+	1	3191_3192	c.231_232insCA	c.(229-234)GCTCATfs	p.A77fs		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	77_78					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			GCCCACCTGCTCATGTGCCCAT	0.644													11	1205	---	---	---	---					
CRIPAK	285464	broad.mit.edu	37	4	1389425	1389426	+	Frame_Shift_Del	DEL	CA	-	-			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr4:1389425_1389426delCA	uc003gdf.2	+	1	4086_4087	c.1126_1127delCA	c.(1126-1128)CACfs	p.H376fs		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	376	10.|Interaction with PAK1.				ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			CCCGCCTGCTCACACGTGCCCA	0.639													11	1103	---	---	---	---					
LIMCH1	22998	broad.mit.edu	37	4	41648508	41648509	+	Frame_Shift_Del	DEL	GA	-	-			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr4:41648508_41648509delGA	uc003gvu.3	+	12	1317_1318	c.1263_1264delGA	c.(1261-1266)CGGAGAfs	p.R421fs	LIMCH1_uc003gvv.3_Frame_Shift_Del_p.R421fs|LIMCH1_uc003gvw.3_Frame_Shift_Del_p.R421fs|LIMCH1_uc003gvx.3_Frame_Shift_Del_p.R409fs|LIMCH1_uc003gwe.3_Frame_Shift_Del_p.R421fs|LIMCH1_uc003gvy.3_Frame_Shift_Del_p.R250fs|LIMCH1_uc003gwa.3_Frame_Shift_Del_p.R262fs|LIMCH1_uc003gvz.3_Frame_Shift_Del_p.R806fs|LIMCH1_uc011byu.1_Frame_Shift_Del_p.R255fs|LIMCH1_uc003gwc.3_Frame_Shift_Del_p.R267fs|LIMCH1_uc003gwd.3_Frame_Shift_Del_p.R255fs|LIMCH1_uc011byv.1_Frame_Shift_Del_p.R172fs	NM_014988	NP_055803	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1 isoform a	421_422	Potential.				actomyosin structure organization		actin binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						TTAGAGAGCGGAGAGAGAGAGA	0.465													7	385	---	---	---	---					
ICK	22858	broad.mit.edu	37	6	52883129	52883129	+	Frame_Shift_Del	DEL	T	-	-			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr6:52883129delT	uc003pbh.2	-	8	1152	c.662delA	c.(661-663)AAGfs	p.K221fs	ICK_uc003pbi.2_Frame_Shift_Del_p.K221fs|ICK_uc003pbj.2_Frame_Shift_Del_p.K221fs	NM_016513	NP_057597	Q9UPZ9	ICK_HUMAN	intestinal cell kinase	221	Protein kinase.				intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			ovary(1)|large_intestine(1)|lung(1)|kidney(1)|central_nervous_system(1)	5	Lung NSC(77;0.103)					TATCATTACCTTTTTTGGTGT	0.502													7	713	---	---	---	---					
KCNQ3	3786	broad.mit.edu	37	8	133150232	133150233	+	Frame_Shift_Ins	INS	-	T	T			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chr8:133150232_133150233insT	uc003ytj.2	-	12	1824_1825	c.1599_1600insA	c.(1597-1602)AAATTCfs	p.K533fs	KCNQ3_uc010mdt.2_Frame_Shift_Ins_p.K533fs	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	533_534					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GTCTCCTTGAATTTTTTTTTAT	0.455													11	514	---	---	---	---					
PAK3	5063	broad.mit.edu	37	X	110406206	110406208	+	In_Frame_Del	DEL	GAA	-	-			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chrX:110406206_110406208delGAA	uc004epa.2	+	6	604_606	c.577_579delGAA	c.(577-579)GAAdel	p.E197del	PAK3_uc010npt.1_In_Frame_Del_p.E182del|PAK3_uc010npu.1_In_Frame_Del_p.E182del|PAK3_uc004eoy.1_5'UTR|PAK3_uc004eoz.2_In_Frame_Del_p.E182del|PAK3_uc011mst.1_RNA|PAK3_uc010npv.1_In_Frame_Del_p.E218del|PAK3_uc010npw.1_In_Frame_Del_p.E203del	NM_001128173	NP_001121645	O75914	PAK3_HUMAN	p21-activated kinase 3 isoform d	197	Linker.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			lung(6)|ovary(3)|large_intestine(1)	10						agatgaagaggaagaagaagaag	0.325										TSP Lung(19;0.15)			10	440	---	---	---	---					
MAMLD1	10046	broad.mit.edu	37	X	149639325	149639327	+	In_Frame_Del	DEL	CAG	-	-			TCGA-IB-7649-01A-11D-2154-08	TCGA-IB-7649-10A-01D-2154-08									Somatic	Phase_I	Capture				Illumina GAIIx	04fede70-370b-42f5-b5d4-6e2139eada5e	5f3e7083-a7fe-45bc-b73b-a05aeafdf4d1	g.chrX:149639325_149639327delCAG	uc004fee.1	+	3	1556_1558	c.1480_1482delCAG	c.(1480-1482)CAGdel	p.Q502del	MAMLD1_uc011mxt.1_In_Frame_Del_p.Q464del|MAMLD1_uc011mxu.1_In_Frame_Del_p.Q477del|MAMLD1_uc011mxv.1_In_Frame_Del_p.Q477del|MAMLD1_uc011mxw.1_In_Frame_Del_p.Q429del	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	502	Poly-Gln.				male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					AAGCcagcaacagcagcagcagc	0.433													9	298	---	---	---	---					
