Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NADK	65220	broad.mit.edu	37	1	1686902	1686902	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr1:1686902G>A	uc009vkw.2	-	7	720	c.599C>T	c.(598-600)CCG>CTG	p.P200L	NADK_uc001aic.2_Missense_Mutation_p.P200L|NADK_uc001aid.3_Missense_Mutation_p.P200L|NADK_uc001aie.2_Missense_Mutation_p.P345L|NADK_uc010nyv.1_Missense_Mutation_p.P168L|NADK_uc009vkx.1_Missense_Mutation_p.P78L	NM_023018	NP_075394	O95544	NADK_HUMAN	NAD kinase	200					ATP metabolic process|NAD metabolic process|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|NAD+ kinase activity|protein binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;8.75e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.33e-23)|GBM - Glioblastoma multiforme(42;1.35e-07)|Colorectal(212;0.000203)|COAD - Colon adenocarcinoma(227;0.000225)|Kidney(185;0.00265)|STAD - Stomach adenocarcinoma(132;0.00655)|BRCA - Breast invasive adenocarcinoma(365;0.00855)|KIRC - Kidney renal clear cell carcinoma(229;0.0382)|Lung(427;0.207)		GGCCATGACCGGAGGGACGCT	0.617													4	195	---	---	---	---	0	0	0.009096	0	0
MST1P2	11209	broad.mit.edu	37	1	16974955	16974955	+	RNA	SNP	A	G	G	rs149751487	by1000genomes	TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr1:16974955A>G	uc010och.1	+	7		c.1415A>G			MST1P2_uc001azk.2_RNA|MST1P2_uc001azl.3_RNA|MST1P2_uc009vox.2_RNA|MST1P2_uc001azm.3_RNA	NR_027504				Homo sapiens cDNA FLJ43241 fis, clone HEART1000010, weakly  similar to Hepatocyte growth factor-like protein precursor.												0						GCATGCTTTGATGTCTGGGAC	0.657													5	50	---	---	---	---	0	0	0.003080	0	0
LRRC42	115353	broad.mit.edu	37	1	54426067	54426067	+	Missense_Mutation	SNP	A	T	T			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr1:54426067A>T	uc001cwj.1	+	4	844	c.644A>T	c.(643-645)GAT>GTT	p.D215V	LRRC42_uc001cwl.1_Missense_Mutation_p.D215V|LRRC42_uc001cwk.1_Missense_Mutation_p.D215V|LRRC42_uc009vzm.1_Missense_Mutation_p.D215V	NM_052940	NP_443172	Q9Y546	LRC42_HUMAN	leucine rich repeat containing 42	215	LRR 3.										0						TGTTTATCTGATGCTGGGGTG	0.368													22	140	---	---	---	---	0	0	0.003954	0	0
MAGI3	260425	broad.mit.edu	37	1	114196558	114196558	+	Silent	SNP	C	A	A			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr1:114196558C>A	uc001edk.2	+	15	2728	c.2547C>A	c.(2545-2547)CCC>CCA	p.P849P	MAGI3_uc001edh.3_Silent_p.P874P|MAGI3_uc001edi.3_Silent_p.P849P|MAGI3_uc010owm.1_Silent_p.P874P|MAGI3_uc001edj.2_Silent_p.P570P	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	874					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCCAGGAGCCCTATGATGTTG	0.522													5	429	---	---	---	---	8.12818e-05	0.000134809	0.001984	1	0
CD48	962	broad.mit.edu	37	1	160651146	160651146	+	Silent	SNP	A	G	G			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr1:160651146A>G	uc001fwn.2	-	3	530	c.498T>C	c.(496-498)TAT>TAC	p.Y166Y	CD48_uc001fwo.1_Silent_p.Y166Y	NM_001778	NP_001769	P09326	CD48_HUMAN	CD48 molecule precursor	166	Ig-like C2-type 2.				blood coagulation|defense response|leukocyte migration	integral to plasma membrane|membrane raft	protein binding				0	all_cancers(52;2.18e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TTTTGTCCCCATACCAGGTGT	0.448													4	230	---	---	---	---	0	0	0.001168	0	0
HSPA7	3311	broad.mit.edu	37	1	161576970	161576970	+	Missense_Mutation	SNP	A	C	C	rs386730		TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr1:161576970A>C	uc010pkp.1	+	1	1122	c.890A>C	c.(889-891)AAG>ACG	p.K297T		NR_024151				RecName: Full=Putative heat shock 70 kDa protein 7; AltName: Full=Heat shock 70 kDa protein B;												0						GACTTCTACAAGTCCATCACT	0.642													3	42	---	---	---	---	0	0	0.004672	0	0
PM20D1	148811	broad.mit.edu	37	1	205814502	205814502	+	Missense_Mutation	SNP	T	C	C			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr1:205814502T>C	uc001hdj.2	-	3	485	c.440A>G	c.(439-441)GAT>GGT	p.D147G	PM20D1_uc009xbr.2_RNA	NM_152491	NP_689704	Q6GTS8	P20D1_HUMAN	peptidase M20 domain containing 1 precursor	147						extracellular region	metal ion binding|peptidase activity			skin(1)	1	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			GATGATGCCATCACGCTCCAA	0.567													4	172	---	---	---	---	0	0	0.001168	0	0
ITGB1	3688	broad.mit.edu	37	10	33215004	33215004	+	Missense_Mutation	SNP	G	C	C			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr10:33215004G>C	uc001iws.3	-	6	717	c.581C>G	c.(580-582)CCT>CGT	p.P194R	ITGB1_uc001iwp.3_Missense_Mutation_p.P194R|ITGB1_uc001iwq.3_Missense_Mutation_p.P194R|ITGB1_uc001iwr.3_Missense_Mutation_p.P194R|ITGB1_uc001iwt.3_Missense_Mutation_p.P194R|ITGB1_uc001iwu.1_Missense_Mutation_p.P194R	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	194	Extracellular (Potential).|VWFA.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				GCTAATGTAAGGCATCACAGT	0.403													6	108	---	---	---	---	0	0	0.001984	0	0
LOC653544	653544	broad.mit.edu	37	10	135491125	135491125	+	Missense_Mutation	SNP	G	A	A	rs140402194	by1000genomes	TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr10:135491125G>A	uc010qvi.1	+	1	847	c.736G>A	c.(736-738)GCG>ACG	p.A246T		NM_001127389	NP_001120861	F5GZ66	F5GZ66_HUMAN	double homeobox, 4-like	246						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CCACACCGGCGCGTGGGGAAC	0.781													4	90	---	---	---	---	0	0	0.004482	0	0
DLAT	1737	broad.mit.edu	37	11	111933176	111933176	+	Missense_Mutation	SNP	C	T	T			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr11:111933176C>T	uc001pmo.2	+	14	2520	c.1861C>T	c.(1861-1863)CGG>TGG	p.R621W	DLAT_uc009yyk.1_Missense_Mutation_p.R516W|DLAT_uc010rwr.1_Missense_Mutation_p.R494W	NM_001931	NP_001922	P10515	ODP2_HUMAN	dihydrolipoamide S-acetyltransferase precursor	621	Catalytic (By similarity).				glycolysis|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial pyruvate dehydrogenase complex	dihydrolipoyllysine-residue acetyltransferase activity|protein binding				0		all_cancers(61;4.53e-11)|all_epithelial(67;2.76e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;4.87e-07)|BRCA - Breast invasive adenocarcinoma(274;6.83e-07)|all cancers(92;9.63e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0557)	NADH(DB00157)	TTGTGATCACCGGGTGGTGGA	0.388													4	212	---	---	---	---	0	0	0.000602	0	0
NRXN3	9369	broad.mit.edu	37	14	79933743	79933743	+	Missense_Mutation	SNP	A	T	T			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr14:79933743A>T	uc001xun.2	+	13	2814	c.2323A>T	c.(2323-2325)ATA>TTA	p.I775L	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Missense_Mutation_p.I143L|NRXN3_uc010asw.2_Missense_Mutation_p.I143L|NRXN3_uc001xur.3_Missense_Mutation_p.I143L	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1148	Extracellular (Potential).|Laminin G-like 6.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		CCAGCTTCACATAGTGAGTAC	0.512													20	93	---	---	---	---	0	0	0.007413	0	0
MAP1A	4130	broad.mit.edu	37	15	43816306	43816306	+	Missense_Mutation	SNP	C	A	A			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr15:43816306C>A	uc001zrt.2	+	4	3102	c.2635C>A	c.(2635-2637)CGT>AGT	p.R879S		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	879						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CCCTTCCTCCCGTACTGAAGC	0.562													5	109	---	---	---	---	0.000602214	0.000975014	0.000602	1	0
CYP11A1	1583	broad.mit.edu	37	15	74659919	74659919	+	Missense_Mutation	SNP	G	C	C			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr15:74659919G>C	uc002axt.2	-	1	163	c.8C>G	c.(7-9)GCC>GGC	p.A3G	CYP11A1_uc002axs.2_5'Flank|CYP11A1_uc010bjm.1_5'Flank|CYP11A1_uc010bjn.1_RNA|CYP11A1_uc010bjo.1_Missense_Mutation_p.A3G|CYP11A1_uc010ulj.1_5'UTR|CYP11A1_uc010bjq.2_Missense_Mutation_p.A3G	NM_000781	NP_000772	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A,	3					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			ovary(2)	2					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	AAGACCCTTGGCCAGCATGCT	0.627													9	38	---	---	---	---	0	0	0.004482	0	0
TM2D3	80213	broad.mit.edu	37	15	102182710	102182710	+	Missense_Mutation	SNP	C	T	T			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr15:102182710C>T	uc002bxi.2	-	6	746	c.716G>A	c.(715-717)GGA>GAA	p.G239E	TM2D3_uc010usg.1_Intron|TM2D3_uc002bxh.2_Missense_Mutation_p.G174E|TM2D3_uc002bxj.2_Missense_Mutation_p.G213E|TM2D3_uc002bxk.2_Missense_Mutation_p.G174E	NM_078474	NP_510883	Q9BRN9	TM2D3_HUMAN	TM2 domain containing 3 isoform a	239						integral to membrane				ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ATCTGCTGGTCCAACATAGCC	0.537													8	178	---	---	---	---	0	0	0.006214	0	0
Unknown	0	broad.mit.edu	37	15	102304772	102304772	+	5'Flank	SNP	T	C	C			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr15:102304772T>C	uc002cbx.1	-						uc002ccc.1_5'Flank|uc002ccf.3_RNA|uc002ccg.3_5'Flank|uc010uth.1_5'Flank|uc002cci.2_5'Flank|uc002ccj.2_5'Flank|uc002cck.2_5'Flank|uc002ccl.1_5'Flank|uc002ccm.1_5'Flank					DQ582460																		CACAGCGGCGTGACGAGACTC	0.587													6	18	---	---	---	---	0	0	0.008291	0	0
STX4	6810	broad.mit.edu	37	16	31050875	31050875	+	Missense_Mutation	SNP	A	G	G			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr16:31050875A>G	uc002eal.2	+	9	940	c.716A>G	c.(715-717)AAT>AGT	p.N239S	STX4_uc002eak.2_Missense_Mutation_p.N237S|STX4_uc002eam.2_Missense_Mutation_p.N161S|uc002ean.1_5'Flank	NM_004604	NP_004595	Q12846	STX4_HUMAN	syntaxin 4	239	Cytoplasmic (Potential).|Interaction with CENPF (By similarity).|t-SNARE coiled-coil homology.				intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity				0						GAGATGATCAATCGGATTGAG	0.567													7	145	---	---	---	---	0	0	0.003080	0	0
GOT2	2806	broad.mit.edu	37	16	58743428	58743428	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr16:58743428G>A	uc002eof.1	-	9	1177	c.1063C>T	c.(1063-1065)CGG>TGG	p.R355W	GOT2_uc010vim.1_Missense_Mutation_p.R312W	NM_002080	NP_002071	P00505	AATM_HUMAN	aspartate aminotransferase 2 precursor	355					aspartate catabolic process|fatty acid transport|gluconeogenesis|response to ethanol	mitochondrial matrix|plasma membrane	L-aspartate:2-oxoglutarate aminotransferase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AGTTGAGTCCGCATGCCAATG	0.507													5	319	---	---	---	---	0	0	0.001168	0	0
Unknown	0	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	G	G	rs149119138	by1000genomes	TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr17:21731144T>G	uc002gyy.3	+	2	571	c.446T>G	c.(445-447)CTG>CGG	p.L149R						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;																		GTCCTGCGTCTGAGAGGTGGT	0.542													6	116	---	---	---	---	0	0	0.001168	0	0
MYO18A	399687	broad.mit.edu	37	17	27425124	27425124	+	Missense_Mutation	SNP	T	G	G			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr17:27425124T>G	uc002hdt.1	-	25	4147	c.3989A>C	c.(3988-3990)CAG>CCG	p.Q1330P	MYO18A_uc010wbc.1_Missense_Mutation_p.Q872P|MYO18A_uc002hds.2_Missense_Mutation_p.Q872P|MYO18A_uc010csa.1_Missense_Mutation_p.Q1330P|MYO18A_uc002hdu.1_Missense_Mutation_p.Q1330P|MYO18A_uc010wbd.1_Missense_Mutation_p.Q999P	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	1330	Potential.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			TGCCCTCACCTGCAGTTCCTT	0.612													10	249	---	---	---	---	0	0	0.006214	0	0
ZNRF4	148066	broad.mit.edu	37	19	5455622	5455622	+	Silent	SNP	G	A	A			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr19:5455622G>A	uc002mca.3	+	1	197	c.120G>A	c.(118-120)AGG>AGA	p.R40R		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	40	Extracellular (Potential).					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		CTGGCCACAGGCCCCCTGGGA	0.657													4	79	---	---	---	---	0	0	0.009096	0	0
TRIP10	9322	broad.mit.edu	37	19	6741105	6741105	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr19:6741105G>A	uc002mfs.2	+	2	175	c.109G>A	c.(109-111)GAA>AAA	p.E37K	TRIP10_uc010dux.1_Missense_Mutation_p.E37K|TRIP10_uc002mfr.2_Missense_Mutation_p.E37K|TRIP10_uc010duy.2_RNA|TRIP10_uc010duz.2_5'UTR	NM_004240	NP_004231	Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	37	FCH.|Required for podosome formation and interaction with AKAP9 and microtubules.|Induction of membrane tubulation.|Required for translocation to the plasma membrane in response to insulin (By similarity).				actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding			ovary(1)	1						AGAACGCACCGAAGTGGAACA	0.627													4	100	---	---	---	---	0	0	0.009096	0	0
MBOAT2	129642	broad.mit.edu	37	2	9083336	9083336	+	Missense_Mutation	SNP	T	C	C			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr2:9083336T>C	uc002qzg.1	-	3	412	c.279A>G	c.(277-279)ATA>ATG	p.I93M	MBOAT2_uc010yix.1_Missense_Mutation_p.I93M	NM_138799	NP_620154	Q6ZWT7	MBOA2_HUMAN	O-acyltransferase (membrane bound) domain	93	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TCTCCACTCCTATGATGATCA	0.318													3	105	---	---	---	---	0	0	0.009096	0	0
USP34	9736	broad.mit.edu	37	2	61417450	61417450	+	Missense_Mutation	SNP	A	G	G			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr2:61417450A>G	uc002sbe.2	-	78	9851	c.9829T>C	c.(9829-9831)TCC>CCC	p.S3277P	USP34_uc002sbd.2_Missense_Mutation_p.S79P	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	3277					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			ACTCGGTTGGAGAAATCAGAC	0.408													3	148	---	---	---	---	0	0	0.009096	0	0
FAM182B	728882	broad.mit.edu	37	20	25848606	25848606	+	RNA	SNP	G	A	A			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr20:25848606G>A	uc002wvd.1	-	1		c.181C>T								Homo sapiens cDNA FLJ30282 fis, clone BRACE2002803.												0						atcaccgtccgggcaggcctg	0													5	7	---	---	---	---	0	0	0.001168	0	0
Unknown	0	broad.mit.edu	37	22	18844766	18844766	+	RNA	SNP	G	A	A			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr22:18844766G>A	uc002zoe.2	+	4		c.2020G>A			uc002zof.2_5'Flank					Homo sapiens cDNA FLJ76361 complete cds.																		CAGCCTCTGAGGGCAGCAGTG	0.557													4	24	---	---	---	---	0	0	0.009096	0	0
ATP13A4	84239	broad.mit.edu	37	3	193120598	193120598	+	Missense_Mutation	SNP	T	C	C			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr3:193120598T>C	uc003ftd.2	-	30	3542	c.3434A>G	c.(3433-3435)TAT>TGT	p.Y1145C	ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	1145	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		TTTTGACTGATAGCCGAAACA	0.443													3	71	---	---	---	---	0	0	0.004672	0	0
SDHAP1	255812	broad.mit.edu	37	3	195692311	195692311	+	Missense_Mutation	SNP	T	C	C	rs62282793	by1000genomes	TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr3:195692311T>C	uc003fvy.2	-	3	346	c.232A>G	c.(232-234)AGC>GGC	p.S78G	SDHAP1_uc003fvx.3_RNA					Homo sapiens full length insert cDNA clone ZC24D06.												0						TTCCCAGTGCTGACGTCCACA	0.607													3	11	---	---	---	---	0	0	0.004672	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140745315	140745315	+	Missense_Mutation	SNP	C	G	G			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr5:140745315C>G	uc003lju.1	+	1	1418	c.1418C>G	c.(1417-1419)TCT>TGT	p.S473C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Missense_Mutation_p.S473C	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	473	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTATCTTCTCTGTGACAGCC	0.532													16	275	---	---	---	---	0	0	0.004007	0	0
BTN2A1	11120	broad.mit.edu	37	6	26465519	26465519	+	Missense_Mutation	SNP	A	T	T			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr6:26465519A>T	uc003nib.1	+	5	1031	c.819A>T	c.(817-819)CAA>CAT	p.Q273H	BTN2A1_uc003nic.1_Missense_Mutation_p.Q273H|BTN2A1_uc003nid.1_Missense_Mutation_p.Q121H|BTN2A1_uc011dko.1_Missense_Mutation_p.Q212H|BTN2A1_uc010jqk.1_Missense_Mutation_p.Q33H	NM_007049	NP_008980	Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1 isoform 1	273	Cytoplasmic (Potential).				lipid metabolic process	integral to plasma membrane				ovary(1)|skin(1)	2						ACAAACTCCAAAAGGAAAAAA	0.433													11	166	---	---	---	---	0	0	0.008291	0	0
ETV1	2115	broad.mit.edu	37	7	13971268	13971268	+	Missense_Mutation	SNP	G	C	C			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr7:13971268G>C	uc011jxq.1	-	9	1400	c.661C>G	c.(661-663)CCC>GCC	p.P221A	ETV1_uc011jxn.1_Missense_Mutation_p.P181A|ETV1_uc011jxo.1_Missense_Mutation_p.P118A|ETV1_uc011jxp.1_Missense_Mutation_p.P163A|ETV1_uc003ssw.3_Missense_Mutation_p.P221A|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Missense_Mutation_p.P203A|ETV1_uc011jxs.1_Missense_Mutation_p.P203A|ETV1_uc010ktv.2_Missense_Mutation_p.P90A	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	221					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						GGTGGGAAGGGGATGTTTGGC	0.552			T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								5	58	---	---	---	---	0	0	0.001984	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				32	63	---	---	---	---	0	0	0.003271	0	0
CSGALNACT1	55790	broad.mit.edu	37	8	19316053	19316053	+	Silent	SNP	G	A	A	rs142456632	byFrequency	TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr8:19316053G>A	uc011kyn.1	-	5	1799	c.735C>T	c.(733-735)TTC>TTT	p.F245F	CSGALNACT1_uc011kyo.1_Silent_p.F245F|CSGALNACT1_uc003wzg.2_RNA|CSGALNACT1_uc011kyp.1_Silent_p.F244F|CSGALNACT1_uc003wzh.2_RNA	NM_001130518	NP_001123990	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate	245	Lumenal (Potential).				anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			central_nervous_system(2)|ovary(1)	3				Colorectal(111;0.182)		TGATGGGGCCGAATGGTCGAA	0.458													6	354	---	---	---	---	0	0	0.001984	0	0
NBN	4683	broad.mit.edu	37	8	90958472	90958472	+	Silent	SNP	A	G	G			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr8:90958472A>G	uc003yej.1	-	13	2076	c.1966T>C	c.(1966-1968)TTG>CTG	p.L656L	NBN_uc003yei.1_Silent_p.L574L|NBN_uc011lgb.1_Silent_p.L656L	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	656					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			AATTCAGTCAATAACAGCTTT	0.318								Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				4	146	---	---	---	---	0	0	0.009096	0	0
EIF2C2	27161	broad.mit.edu	37	8	141549494	141549494	+	Silent	SNP	G	A	A			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr8:141549494G>A	uc003yvn.2	-	16	2134	c.2094C>T	c.(2092-2094)TAC>TAT	p.Y698Y	EIF2C2_uc010men.2_Silent_p.Y621Y|EIF2C2_uc010meo.2_Silent_p.Y698Y	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	698	Piwi.				mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			TCCCGGGCTGGTAGTCTTTTT	0.557													11	105	---	---	---	---	0	0	0.008291	0	0
ABL1	25	broad.mit.edu	37	9	133753888	133753888	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr9:133753888G>A	uc004bzw.2	+	8	1360	c.1357G>A	c.(1357-1359)GAG>AAG	p.E453K	ABL1_uc004bzv.2_Missense_Mutation_p.E472K	NM_005157	NP_005148	P00519	ABL1_HUMAN	c-abl oncogene 1, receptor tyrosine kinase	453	Protein kinase.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding	p.E453K(2)|p.E453D(1)|p.E453L(1)		haematopoietic_and_lymphoid_tissue(807)|lung(5)|stomach(2)|central_nervous_system(1)|breast(1)|skin(1)	817		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	TGAGCTGCTAGAGAAGGACTA	0.507			T|Mis	BCR|ETV6|NUP214	CML|ALL|T-ALL								5	303	---	---	---	---	0	0	0.001168	0	0
Unknown	0	broad.mit.edu	37	1	36161071	36161071	+	IGR	DEL	C	-	-			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr1:36161071delC								PSMB2 (53928 upstream) : C1orf216 (18406 downstream)																							cttttccccaccccgtaaatt	0.164													2	4	---	---	---	---					
HMGB1	3146	broad.mit.edu	37	13	31035567	31035569	+	In_Frame_Del	DEL	TCC	-	-			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr13:31035567_31035569delTCC	uc001usw.2	-	5	757_759	c.573_575delGGA	c.(571-576)GAGGAA>GAA	p.191_192EE>E	HMGB1_uc001usz.2_In_Frame_Del_p.191_192EE>E|HMGB1_uc001usv.2_3'UTR|HMGB1_uc001usx.2_In_Frame_Del_p.191_192EE>E|HMGB1_uc001usy.2_In_Frame_Del_p.152_153EE>E|HMGB1_uc001uta.1_3'UTR	NM_002128	NP_002119	P09429	HMGB1_HUMAN	high-mobility group box 1	191_192	Asp/Glu-rich (acidic).				base-excision repair, DNA ligation|dendritic cell chemotaxis|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|inflammatory response to antigenic stimulus|innate immune response|myeloid dendritic cell activation|negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|neuron projection development|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	cell surface|condensed chromosome|extracellular space|nucleolus|nucleoplasm	chemoattractant activity|cytokine activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|repressing transcription factor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			ovary(1)	1		Lung SC(185;0.0257)		all cancers(112;0.072)|OV - Ovarian serous cystadenocarcinoma(117;0.177)|Lung(94;0.216)|GBM - Glioblastoma multiforme(144;0.232)		ctcttcatcttcctcatcttcct	0.212													4	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	17	20397388	20397399	+	IGR	DEL	GCCGCCCCCGAT	-	-	rs71728273		TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr17:20397388_20397399delGCCGCCCCCGAT								LGALS9B (26540 upstream) : CCDC144NL (369311 downstream)																							TGCGGCTGGAgccgcccccgatgccgcccccg	0.580													3	3	---	---	---	---					
Unknown	0	broad.mit.edu	37	3	111197863	111197868	+	IGR	DEL	CACACA	-	-	rs7650195		TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr3:111197863_111197868delCACACA								PVRL3 (285490 upstream) : CD96 (63058 downstream)																							CGAACAGCCTcacacacacacacaca	0.442													3	3	---	---	---	---					
Unknown	0	broad.mit.edu	37	3	146995077	146995077	+	IGR	DEL	A	-	-			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr3:146995077delA								PLSCR5 (671074 upstream) : ZIC4 (108760 downstream)																							TCTGGACTGtaaaaaaaaaaa	0.209													3	5	---	---	---	---					
TG	7038	broad.mit.edu	37	8	133980057	133980058	+	Frame_Shift_Ins	INS	-	TT	TT			TCGA-EL-A3GY-01A-21D-A202-08	TCGA-EL-A3GY-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7977f37-60b9-4d9e-b928-0ac02f1a17e8	a35c71ab-41c7-4fe3-b279-71cbd8449992	g.chr8:133980057_133980058insTT	uc003ytw.2	+	31	5746_5747	c.5705_5706insTT	c.(5704-5706)TCTfs	p.S1902fs	TG_uc010mdw.2_Frame_Shift_Ins_p.S661fs|TG_uc011ljb.1_Frame_Shift_Ins_p.S271fs|TG_uc011ljc.1_Frame_Shift_Ins_p.S56fs|TG_uc010mdx.1_RNA	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1902	Type IIIA.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CAGGAGCACTCTTTCTGTCAGC	0.495													7	58	---	---	---	---					
