Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
VPS13D	55187	broad.mit.edu	37	1	12321060	12321060	+	Missense_Mutation	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:12321060C>T	uc001atv.2	+	12	1409	c.1268C>T	c.(1267-1269)CCC>CTC	p.P423L	VPS13D_uc001atw.2_Missense_Mutation_p.P423L	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	423					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GCCCCAGAACCCGGTGGAGGC	0.562000													50	137					0	0	0	0
CELA2A	63036	broad.mit.edu	37	1	15793937	15793937	+	Silent	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:15793937C>T	uc001awk.2	+	7	722	c.696C>T	c.(694-696)CAC>CAT	p.H232H		NM_033440	NP_254275	P08217	CEL2A_HUMAN	elastase 2A preproprotein	232	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						GGCAGGTGCACGGCATCGTCA	0.592000													19	59					0	0	0	0
MACF1	23499	broad.mit.edu	37	1	39775248	39775248	+	Missense_Mutation	SNP	A	C	C			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:39775248A>C	uc010ois.1	+	25	3016	c.2811A>C	c.(2809-2811)GAA>GAC	p.E937D	MACF1_uc001cda.1_Missense_Mutation_p.E845D|MACF1_uc001cdc.1_Missense_Mutation_p.E24D|MACF1_uc009vvq.1_5'UTR|MACF1_uc001cdb.1_Missense_Mutation_p.E24D	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	937					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTAGGGTCGAACAATCTTATC	0.408000													20	63					0	0	0	0
NBPF10	100132406	broad.mit.edu	37	1	145365372	145365372	+	Missense_Mutation	SNP	C	G	G	rs4126496		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:145365372C>G	uc001end.3	+	82	10257	c.10222C>G	c.(10222-10224)CTT>GTT	p.L3408V	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3333											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TTCAGGTTGTCTTGAACTGTG	0.488000													8	31					0	0	0	0
APCS	325	broad.mit.edu	37	1	159558139	159558139	+	Missense_Mutation	SNP	G	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:159558139G>A	uc001ftv.2	+	2	409	c.313G>A	c.(313-315)GAA>AAA	p.E105K		NM_001639	NP_001630	P02743	SAMP_HUMAN	serum amyloid P component precursor	105	Pentaxin.				acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding			ovary(1)|breast(1)	2	all_hematologic(112;0.0429)					CAAAGTTATCGAAAAGTTCCC	0.423000													27	69					0	0	0	0
AVPR1B	553	broad.mit.edu	37	1	206224583	206224583	+	Missense_Mutation	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:206224583C>T	uc001hds.2	+	1	301	c.143C>T	c.(142-144)GCG>GTG	p.A48V		NM_000707	NP_000698	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	48	Helical; Name=1; (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			ovary(2)|large_intestine(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	CTGGTGCTGGCGACCGGGGGC	0.677000													38	138					0	0	0	0
SPATA17	128153	broad.mit.edu	37	1	217856683	217856683	+	Silent	SNP	A	G	G			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:217856683A>G	uc001hlh.1	+	5	401	c.375A>G	c.(373-375)TCA>TCG	p.S125S	SPATA17_uc009xdr.1_RNA|SPATA17_uc001hli.2_Silent_p.S125S	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	125						cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		AAGTCGTTTCAGAGACCAATG	0.348000													34	91					0	0	0	0
ACTN2	88	broad.mit.edu	37	1	236902795	236902795	+	Missense_Mutation	SNP	G	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:236902795G>A	uc001hyf.2	+	10	1274	c.1070G>A	c.(1069-1071)CGT>CAT	p.R357H	ACTN2_uc001hyg.2_Missense_Mutation_p.R149H|ACTN2_uc009xgi.1_Missense_Mutation_p.R357H|ACTN2_uc010pxu.1_Intron|ACTN2_uc001hyh.2_Missense_Mutation_p.R45H	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	357	Spectrin 1.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			ATCAGCAACCGTCCTGCCTTC	0.607000													10	40					0	0	0	0
SDCCAG8	10806	broad.mit.edu	37	1	243504378	243504378	+	Missense_Mutation	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:243504378C>T	uc001hzw.2	+	11	1415	c.1259C>T	c.(1258-1260)GCC>GTC	p.A420V	SDCCAG8_uc010pyk.1_Missense_Mutation_p.A275V|SDCCAG8_uc010pyl.1_Missense_Mutation_p.A232V|SDCCAG8_uc001hzx.2_Missense_Mutation_p.A232V	NM_006642	NP_006633	Q86SQ7	SDCG8_HUMAN	serologically defined colon cancer antigen 8	420	Potential.|Sufficient for homodimerization (By similarity).				establishment of cell polarity|G2/M transition of mitotic cell cycle|tube formation	cell-cell junction|centriole|cytosol	protein binding				0	all_cancers(71;0.000545)|all_epithelial(71;0.000509)|all_lung(81;0.0821)|Ovarian(71;0.0919)|all_neural(11;0.101)|Breast(184;0.218)	all_cancers(173;0.00395)	all cancers(7;1.58e-07)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00392)	COAD - Colon adenocarcinoma(196;0.145)		CAACTGGAGGCCCAGGTGGAA	0.373000													13	37					0	0	0	0
CNST	163882	broad.mit.edu	37	1	246755211	246755211	+	Missense_Mutation	SNP	G	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:246755211G>T	uc001ibp.2	+	2	725	c.347G>T	c.(346-348)AGC>ATC	p.S116I	CNST_uc001ibo.3_Missense_Mutation_p.S116I	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	116					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						AGTCCAAGAAGCAAAAAAGGG	0.378000													6	18					0.00116845	0.00119181	1	0
MKX	283078	broad.mit.edu	37	10	27964468	27964468	+	Missense_Mutation	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr10:27964468C>T	uc001ity.3	-	6	1079	c.854G>A	c.(853-855)GGA>GAA	p.G285E	MKX_uc001itx.3_Missense_Mutation_p.G285E	NM_173576	NP_775847	Q8IYA7	MKX_HUMAN	mohawk homeobox	285					muscle organ development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTTATTGGATCCGTTTTCCAG	0.378000													8	30					0	0	0	0
C11orf41	25758	broad.mit.edu	37	11	33667394	33667394	+	Missense_Mutation	SNP	G	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr11:33667394G>A	uc001mup.3	+	16	4823	c.4699G>A	c.(4699-4701)GCC>ACC	p.A1567T		NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	1561						integral to membrane				ovary(2)	2						GCTGGAGGAGGCCTTCAGCCT	0.657000													11	33					0	0	0	0
ABTB2	25841	broad.mit.edu	37	11	34182507	34182507	+	Silent	SNP	G	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr11:34182507G>A	uc001mvl.1	-	11	2012	c.1782C>T	c.(1780-1782)AAC>AAT	p.N594N		NM_145804	NP_665803	Q8N961	ABTB2_HUMAN	ankyrin repeat and BTB (POZ) domain containing	594							DNA binding			central_nervous_system(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				CCAGCTCCTCGTTGTACTCCT	0.597000													14	46					0	0	0	0
F2	2147	broad.mit.edu	37	11	46741250	46741250	+	Splice_Site	SNP	A	G	G			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr11:46741250A>G	uc001ndf.3	+	2	123	c.80_splice	c.e2-2	p.V27_splice	F2_uc001ndg.3_Splice_Site	NM_000506	NP_000497	P00734	THRB_HUMAN	coagulation factor II preproprotein						activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity			ovary(3)	3		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)	ACCGCCTTACAGTGTTCCTGG	0.647000													7	18					0	0	0	0
OR9Q1	219956	broad.mit.edu	37	11	57947810	57947810	+	Missense_Mutation	SNP	G	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr11:57947810G>T	uc001nmj.2	+	3	1210	c.894G>T	c.(892-894)GAG>GAT	p.E298D		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	298	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				AAGTGAAGGAGGCCCTGAGAA	0.473000													11	33					1.05317e-09	1.18048e-09	1	0
PPP2R5B	5526	broad.mit.edu	37	11	64695279	64695279	+	Silent	SNP	A	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr11:64695279A>T	uc001oby.2	+	4	987	c.402A>T	c.(400-402)TCA>TCT	p.S134S	PPP2R5B_uc001obz.2_Silent_p.S134S	NM_006244	NP_006235	Q15173	2A5B_HUMAN	beta isoform of regulatory subunit B56, protein	134					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(2)	2						CTCAGATCTCAGTGAATATCT	0.463000													15	50					0	0	0	0
Unknown	0	broad.mit.edu	37	11	104778291	104778291	+	RNA	SNP	C	T	T	rs11825902	by1000genomes	TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr11:104778291C>T	uc001phy.2	-	1		c.1142G>A			uc001phz.2_RNA|uc001pia.1_Intron					Homo sapiens mRNA; cDNA DKFZp667O0320 (from clone DKFZp667O0320).																		AACGTGCTGTCGGAGGACTTG	0.478000													6	27					0	0	0	0
NCAPD3	23310	broad.mit.edu	37	11	134023217	134023217	+	Missense_Mutation	SNP	T	G	G			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr11:134023217T>G	uc001qhd.1	-	33	4900	c.4294A>C	c.(4294-4296)ATC>CTC	p.I1432L	NCAPD3_uc010scm.1_RNA|NCAPD3_uc009zda.1_RNA|NCAPD3_uc001qhc.1_Missense_Mutation_p.I382L	NM_015261	NP_056076	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	1432					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		GGTGTCCCGATGTAACTGACC	0.527000													52	202					0	0	0	0
CACNA1C	775	broad.mit.edu	37	12	2595423	2595423	+	Missense_Mutation	SNP	T	C	C			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr12:2595423T>C	uc009zdu.1	+	6	1224	c.911T>C	c.(910-912)ATA>ACA	p.I304T	CACNA1C_uc009zdv.1_Missense_Mutation_p.I304T|CACNA1C_uc001qkb.2_Missense_Mutation_p.I304T|CACNA1C_uc001qkc.2_Missense_Mutation_p.I304T|CACNA1C_uc001qke.2_Missense_Mutation_p.I304T|CACNA1C_uc001qkf.2_Missense_Mutation_p.I304T|CACNA1C_uc001qjz.2_Missense_Mutation_p.I304T|CACNA1C_uc001qkd.2_Missense_Mutation_p.I304T|CACNA1C_uc001qkg.2_Missense_Mutation_p.I304T|CACNA1C_uc009zdw.1_Missense_Mutation_p.I304T|CACNA1C_uc001qkh.2_Missense_Mutation_p.I304T|CACNA1C_uc001qkl.2_Missense_Mutation_p.I304T|CACNA1C_uc001qkn.2_Missense_Mutation_p.I304T|CACNA1C_uc001qko.2_Missense_Mutation_p.I304T|CACNA1C_uc001qkp.2_Missense_Mutation_p.I304T|CACNA1C_uc001qkr.2_Missense_Mutation_p.I304T|CACNA1C_uc001qku.2_Missense_Mutation_p.I304T|CACNA1C_uc001qkq.2_Missense_Mutation_p.I304T|CACNA1C_uc001qks.2_Missense_Mutation_p.I304T|CACNA1C_uc001qkt.2_Missense_Mutation_p.I304T|CACNA1C_uc001qka.1_5'UTR|CACNA1C_uc001qki.1_Missense_Mutation_p.I40T|CACNA1C_uc001qkj.1_Missense_Mutation_p.I40T|CACNA1C_uc001qkk.1_Missense_Mutation_p.I40T|CACNA1C_uc001qkm.1_Missense_Mutation_p.I40T	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	304	I.|Extracellular (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CAGGAGGGCATAGCAGGTAAG	0.587000													13	57					0	0	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54902309	54902309	+	Missense_Mutation	SNP	G	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr12:54902309G>A	uc001sgc.3	+	5	579	c.500G>A	c.(499-501)GGG>GAG	p.G167E	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_Missense_Mutation_p.G117E	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	167					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						ATGCTGCATGGGCATGGGTGA	0.428000													75	183					0	0	0	0
SBNO1	55206	broad.mit.edu	37	12	123782568	123782568	+	Missense_Mutation	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr12:123782568C>T	uc010tap.1	-	30	3996	c.3996G>A	c.(3994-3996)ATG>ATA	p.M1332I	SBNO1_uc009zxv.2_RNA|SBNO1_uc010tao.1_Missense_Mutation_p.M1331I|SBNO1_uc010taq.1_Missense_Mutation_p.M283I	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1332							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		GCACGATCTGCATCTTCACGT	0.433000													30	100					0	0	0	0
PIWIL1	9271	broad.mit.edu	37	12	130847589	130847589	+	Missense_Mutation	SNP	G	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr12:130847589G>A	uc001uik.2	+	18	2185	c.2095G>A	c.(2095-2097)GTG>ATG	p.V699M	PIWIL1_uc001uij.1_Missense_Mutation_p.V699M	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	699	Piwi.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		CCGGATCATCGTGTACCGCGA	0.488000													27	50					0	0	0	0
DCLK1	9201	broad.mit.edu	37	13	36402442	36402442	+	Nonsense_Mutation	SNP	G	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr13:36402442G>T	uc001uvf.2	-	9	1465	c.1232C>A	c.(1231-1233)TCG>TAG	p.S411*	DCLK1_uc001uve.3_Nonsense_Mutation_p.S104*|DCLK1_uc010teh.1_Nonsense_Mutation_p.S104*|DCLK1_uc010abk.2_Intron	NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	411	Protein kinase.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		TCTAGCAGTCGATCTGCGAAG	0.328000													11	6					8.00594e-06	8.41862e-06	1	0
CCNA1	8900	broad.mit.edu	37	13	37011963	37011963	+	Silent	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr13:37011963C>T	uc001uvr.3	+	3	845	c.495C>T	c.(493-495)GAC>GAT	p.D165D	CCNA1_uc010teo.1_Silent_p.D121D|CCNA1_uc010abq.2_Silent_p.D121D|CCNA1_uc010abp.2_Silent_p.D121D|CCNA1_uc001uvs.3_Silent_p.D164D|CCNA1_uc010abr.2_Intron	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	165					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		ATGAAGTAGACACCGGCACAC	0.488000													30	47					0	0	0	0
AHNAK2	113146	broad.mit.edu	37	14	105410834	105410835	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr14:105410834_105410835CC>AA	uc010axc.1	-	7	11073_11074	c.10953_10954GG>TT	c.(10951-10956)TCGGCC>TCTTCC	p.A3652S	AHNAK2_uc001ypx.2_Missense_Mutation_p.A3552S	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3652						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TTCCCTGGGGCCGATACCCTGA	0.584000													77	160					0	0	0	0
AHNAK2	113146	broad.mit.edu	37	14	105416396	105416396	+	Missense_Mutation	SNP	C	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr14:105416396C>A	uc010axc.1	-	7	5512	c.5392G>T	c.(5392-5394)GCC>TCC	p.A1798S	AHNAK2_uc001ypx.2_Missense_Mutation_p.A1698S	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1798						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCCAGCTTGGCTCCTGGAGCC	0.627000													12	57					2.31682e-05	2.41139e-05	1	0
MAP1A	4130	broad.mit.edu	37	15	43814461	43814461	+	Missense_Mutation	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr15:43814461C>T	uc001zrt.2	+	4	1257	c.790C>T	c.(790-792)CGT>TGT	p.R264C		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	264						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GAAGATTGTGCGTGTGCTTTT	0.542000													16	46					0	0	0	0
SH2D7	646892	broad.mit.edu	37	15	78390833	78390833	+	Silent	SNP	G	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr15:78390833G>A	uc010blb.1	+	4	540	c.540G>A	c.(538-540)AAG>AAA	p.K180K		NM_001101404	NP_001094874	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	180											0						TCCCCGACAAGGCCGCCAGCC	0.602000													18	34					0	0	0	0
FANCI	55215	broad.mit.edu	37	15	89857856	89857856	+	Missense_Mutation	SNP	G	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr15:89857856G>T	uc010bnp.1	+	36	3824	c.3734G>T	c.(3733-3735)CGG>CTG	p.R1245L	FANCI_uc002bnm.1_Missense_Mutation_p.R1185L|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.R1005L|FANCI_uc002bnq.1_Missense_Mutation_p.R658L	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	1245					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					AGAGTTCTTCGGGAAACCAAG	0.378000								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				18	48					1.87028e-06	1.98717e-06	1	0
ACSM2A	123876	broad.mit.edu	37	16	20494425	20494425	+	Missense_Mutation	SNP	G	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr16:20494425G>A	uc010bwe.2	+	14	1794	c.1555G>A	c.(1555-1557)GAC>AAC	p.D519N	ACSM2A_uc002dhf.3_Missense_Mutation_p.D519N|ACSM2A_uc002dhg.3_Missense_Mutation_p.D519N|ACSM2A_uc010vay.1_Missense_Mutation_p.D440N|ACSM2A_uc002dhh.3_Missense_Mutation_p.D149N	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	519					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						CCTGTCCCATGACCCAGAACA	0.522000													34	81					0	0	0	0
SRCAP	10847	broad.mit.edu	37	16	30734936	30734936	+	Missense_Mutation	SNP	C	G	G			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr16:30734936C>G	uc002dze.1	+	25	4576	c.4191C>G	c.(4189-4191)ATC>ATG	p.I1397M	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.I1192M|SRCAP_uc010bzz.1_Missense_Mutation_p.I967M	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1397	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CCTTGACCATCTCTTCTCCTC	0.567000													43	137					0	0	0	0
PHKB	5257	broad.mit.edu	37	16	47733262	47733262	+	Silent	SNP	G	A	A	rs146134171	byFrequency	TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr16:47733262G>A	uc002eev.3	+	31	3319	c.3267G>A	c.(3265-3267)CCG>CCA	p.P1089P	PHKB_uc002eeu.3_Silent_p.P1082P|PHKB_uc002eew.3_Silent_p.P330P	NM_000293	NP_000284	Q93100	KPBB_HUMAN	phosphorylase kinase, beta isoform a	1089					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			ovary(1)|large_intestine(1)|breast(1)	3		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				ATGATGACCCGTGTCTGATTA	0.463000													36	123					0	0	0	0
SLC7A6	9057	broad.mit.edu	37	16	68330382	68330382	+	Missense_Mutation	SNP	G	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr16:68330382G>A	uc002evt.1	+	10	1544	c.1235G>A	c.(1234-1236)CGC>CAC	p.R412H	SLC7A6_uc002evu.1_Missense_Mutation_p.R412H|SLC7A6_uc002evv.1_RNA|SLC7A6_uc010cfc.1_RNA	NM_001076785	NP_001070253	Q92536	YLAT2_HUMAN	solute carrier family 7 (cationic amino acid	412	Cytoplasmic (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|antiporter activity			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.0948)		CTCTACCTCCGCTGGAAGGAG	0.577000													46	132					0	0	0	0
CDH13	1012	broad.mit.edu	37	16	83711944	83711944	+	Silent	SNP	C	T	T	rs147140848	by1000genomes	TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr16:83711944C>T	uc002fgx.2	+	10	1536	c.1416C>T	c.(1414-1416)AAC>AAT	p.N472N	CDH13_uc010vns.1_Silent_p.N519N|CDH13_uc010vnt.1_Silent_p.N218N|CDH13_uc010vnu.1_Silent_p.N433N	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	472	Cadherin 3.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		TGGATGTCAACGAGGGCCCAG	0.602000													18	96					0	0	0	0
PFAS	5198	broad.mit.edu	37	17	8170160	8170160	+	Missense_Mutation	SNP	G	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr17:8170160G>T	uc002gkr.2	+	23	3052	c.2911G>T	c.(2911-2913)GCT>TCT	p.A971S	PFAS_uc010vuv.1_Missense_Mutation_p.A547S|PFAS_uc002gks.2_Missense_Mutation_p.A50S	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	971					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TTACCGGGATGCTGGCCTCCA	0.662000													20	44					8.10497e-08	8.88932e-08	1	0
Unknown	0	broad.mit.edu	37	17	20747222	20747222	+	RNA	SNP	C	A	A	rs111232194	by1000genomes	TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr17:20747222C>A	uc010crb.1	+	2		c.610C>A								Homo sapiens cDNA clone IMAGE:6269068, partial cds.																		GACACCAAGACGACCTACTGC	0.547000													5	15					1.08611e-07	1.16614e-07	1	0
BCAS3	54828	broad.mit.edu	37	17	58824568	58824568	+	Missense_Mutation	SNP	G	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr17:58824568G>A	uc002iyv.3	+	6	440	c.331G>A	c.(331-333)GAA>AAA	p.E111K	BCAS3_uc010wow.1_Intron|BCAS3_uc002iyu.3_Missense_Mutation_p.E111K|BCAS3_uc002iyw.3_Missense_Mutation_p.E107K	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	111	WD 1.					nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			GATCAGTGGTGAAGCACAAGA	0.378000													53	106					0	0	0	0
EXOC7	23265	broad.mit.edu	37	17	74093934	74093934	+	Missense_Mutation	SNP	C	T	T	rs151088510	byFrequency	TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr17:74093934C>T	uc002jqs.2	-	5	678	c.583G>A	c.(583-585)GTG>ATG	p.V195M	EXOC7_uc010dgv.1_Missense_Mutation_p.V142M|EXOC7_uc002jqq.2_Missense_Mutation_p.V195M|EXOC7_uc010wsw.1_Missense_Mutation_p.V195M|EXOC7_uc010wsx.1_Missense_Mutation_p.V195M|EXOC7_uc002jqr.2_Missense_Mutation_p.V195M|EXOC7_uc010wsv.1_Missense_Mutation_p.V154M|EXOC7_uc002jqu.2_Missense_Mutation_p.V195M	NM_001145297	NP_001138769	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7 isoform 4	195					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding				0			LUSC - Lung squamous cell carcinoma(166;0.187)			TCCTGGAGCACGCTCTCGGGC	0.592000													24	128					0	0	0	0
ZNF556	80032	broad.mit.edu	37	19	2877759	2877759	+	Missense_Mutation	SNP	T	G	G			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:2877759T>G	uc002lwp.1	+	4	890	c.803T>G	c.(802-804)TTC>TGC	p.F268C	ZNF556_uc002lwq.2_Missense_Mutation_p.F267C	NM_024967	NP_079243	Q9HAH1	ZN556_HUMAN	zinc finger protein 556	268	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGAAAGCCTTCAGGTGTCAG	0.542000													8	37					0	0	0	0
PTPRS	5802	broad.mit.edu	37	19	5274277	5274277	+	Missense_Mutation	SNP	G	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:5274277G>A	uc002mbv.2	-	3	404	c.170C>T	c.(169-171)ACG>ATG	p.T57M	PTPRS_uc002mbu.1_Missense_Mutation_p.T57M|PTPRS_uc010xin.1_Missense_Mutation_p.T57M|PTPRS_uc002mbw.2_Missense_Mutation_p.T57M|PTPRS_uc002mbx.2_Missense_Mutation_p.T57M|PTPRS_uc002mby.2_Missense_Mutation_p.T57M|PTPRS_uc002mbz.1_Missense_Mutation_p.T57M	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	57	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GGGGTCACCCGTGGCCTGACA	0.597000													9	34					0	0	0	0
ZNF799	90576	broad.mit.edu	37	19	12501842	12501842	+	Missense_Mutation	SNP	A	T	T	rs78572821		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:12501842A>T	uc010dyt.2	-	4	1520	c.1370T>A	c.(1369-1371)TTT>TAT	p.F457Y	ZNF799_uc002mts.3_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	zinc finger protein 799	457	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						GAAATCAATAAAGGCTTTCCC	0.388000													24	42					0	0	0	0
MYO9B	4650	broad.mit.edu	37	19	17283727	17283727	+	Missense_Mutation	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:17283727C>T	uc010eak.2	+	13	2247	c.2095C>T	c.(2095-2097)CGG>TGG	p.R699W	MYO9B_uc002nfi.2_Missense_Mutation_p.R699W|MYO9B_uc002nfj.1_Missense_Mutation_p.R699W	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	699	Myosin head-like.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						GGCAGTGCTTCGGGAGGCCGG	0.687000													29	57					0	0	0	0
MYO9B	4650	broad.mit.edu	37	19	17322568	17322568	+	Missense_Mutation	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:17322568C>T	uc010eak.2	+	39	6195	c.6043C>T	c.(6043-6045)CGG>TGG	p.R2015W	MYO9B_uc002nfi.2_Missense_Mutation_p.R2015W|MYO9B_uc002nfm.1_Missense_Mutation_p.R175W	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	2015	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						GCGGGCCGGGCGGGGGGCCTC	0.697000													16	37					0	0	0	0
DYRK1B	9149	broad.mit.edu	37	19	40319075	40319075	+	Silent	SNP	C	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:40319075C>A	uc002omj.2	-	6	949	c.669G>T	c.(667-669)ACG>ACT	p.T223T	DYRK1B_uc002omi.2_Silent_p.T223T|DYRK1B_uc002omk.2_Silent_p.T223T	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	223	Protein kinase.				positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			AGAGCAGTGCCGTGCAGAGCT	0.602000													6	13					0.000157383	0.000162152	1	0
RCN3	57333	broad.mit.edu	37	19	50040344	50040344	+	Missense_Mutation	SNP	G	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:50040344G>T	uc002poj.2	+	4	947	c.500G>T	c.(499-501)CGG>CTG	p.R167L		NM_020650	NP_065701	Q96D15	RCN3_HUMAN	reticulocalbin 3, EF-hand calcium binding domain	167	EF-hand 3.					endoplasmic reticulum lumen	calcium ion binding|protein binding			ovary(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0159)		ATGCTGGCTCGGGACGAGCGG	0.572000													69	142					1.37693e-34	1.63311e-34	1	0
KLK10	5655	broad.mit.edu	37	19	51518155	51518155	+	Silent	SNP	C	G	G	rs138296032		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:51518155C>G	uc002puy.2	-	6	813	c.732G>C	c.(730-732)TCG>TCC	p.S244S	KLK10_uc002puz.2_Silent_p.S244S|KLK10_uc002pva.2_Silent_p.S244S	NM_145888	NP_665895	O43240	KLK10_HUMAN	kallikrein-related peptidase 10 preproprotein	244	Peptidase S1.				cell cycle|proteolysis	extracellular region	serine-type endopeptidase activity			lung(2)	2		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00885)		AAACACCCCACGAGAGGATGC	0.537000													12	52					0	0	0	0
ZIM3	114026	broad.mit.edu	37	19	57647237	57647237	+	Silent	SNP	G	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:57647237G>A	uc002qnz.1	-	5	854	c.468C>T	c.(466-468)GGC>GGT	p.G156G		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	156					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATGGATTATTGCCAACTAATT	0.368000													58	120					0	0	0	0
CCDC85A	114800	broad.mit.edu	37	2	56419679	56419679	+	Missense_Mutation	SNP	A	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr2:56419679A>T	uc002rzn.2	+	2	846	c.344A>T	c.(343-345)GAC>GTC	p.D115V		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	115										breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CTGGATGATGACCGGCAGAAA	0.532000													45	22					0	0	0	0
C2orf51	200523	broad.mit.edu	37	2	88828764	88828764	+	Silent	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr2:88828764C>T	uc002stb.1	+	4	457	c.315C>T	c.(313-315)ACC>ACT	p.T105T		NM_152670	NP_689883	Q96LM6	TSC21_HUMAN	chromosome 2 open reading frame 51	105						nucleus				skin(1)	1						TCACCAGCACCTGCCATTTCA	0.592000													24	122					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141032097	141032097	+	Silent	SNP	G	C	C			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr2:141032097G>C	uc002tvj.1	-	85	14010	c.13038C>G	c.(13036-13038)GTC>GTG	p.V4346V		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4346	Extracellular (Potential).|EGF-like 13.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCGTTGGACAGACACATTCAA	0.408000										TSP Lung(27;0.18)			50	32					0	0	0	0
NEB	4703	broad.mit.edu	37	2	152468860	152468860	+	Missense_Mutation	SNP	C	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr2:152468860C>A	uc010fnx.2	-	74	11107	c.10916G>T	c.(10915-10917)TGG>TTG	p.W3639L		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3639	Nebulin 100.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		AATGGGAACCCATCCTATGCC	0.458000													30	17					4.31634e-10	4.94681e-10	1	0
TTN	7273	broad.mit.edu	37	2	179456400	179456400	+	Missense_Mutation	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr2:179456400C>T	uc010zfg.1	-	252	52666	c.52442G>A	c.(52441-52443)CGT>CAT	p.R17481H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R11176H|TTN_uc010zfi.1_Missense_Mutation_p.R11109H|TTN_uc010zfj.1_Missense_Mutation_p.R10984H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18408							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCTTTTACACGGAATCTATA	0.398000													130	70					0	0	0	0
TMEFF2	23671	broad.mit.edu	37	2	192818509	192818509	+	Silent	SNP	T	C	C			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr2:192818509T>C	uc002utc.2	-	9	1318	c.924A>G	c.(922-924)CTA>CTG	p.L308L		NM_016192	NP_057276	Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two	308	Required for shedding.|Extracellular (Potential).					extracellular region|integral to membrane				lung(2)|pancreas(1)|breast(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			GAACAACGTATAGAACACTGT	0.443000													33	22					0	0	0	0
FN1	2335	broad.mit.edu	37	2	216246973	216246973	+	Missense_Mutation	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr2:216246973C>T	uc002vfa.2	-	32	5392	c.5126G>A	c.(5125-5127)AGC>AAC	p.S1709N	FN1_uc002vfb.2_Missense_Mutation_p.S1618N|FN1_uc002vfc.2_Missense_Mutation_p.S1618N|FN1_uc002vfd.2_Missense_Mutation_p.S1709N|FN1_uc002vfe.2_Missense_Mutation_p.S1618N|FN1_uc002vff.2_Missense_Mutation_p.S1618N|FN1_uc002vfg.2_Missense_Mutation_p.S1618N|FN1_uc002vfh.2_Missense_Mutation_p.S1618N|FN1_uc002vfi.2_Missense_Mutation_p.S1709N|FN1_uc002vfj.2_Missense_Mutation_p.S1709N|FN1_uc002vez.2_5'UTR|FN1_uc010zjp.1_Missense_Mutation_p.S336N|FN1_uc010fvc.1_Missense_Mutation_p.S71N|FN1_uc010fvd.1_Missense_Mutation_p.S71N	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACTCTCTCCGCTTGGATTCTG	0.443000													17	28					0	0	0	0
RIN2	54453	broad.mit.edu	37	20	19981297	19981297	+	Missense_Mutation	SNP	G	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr20:19981297G>A	uc002wro.1	+	11	2441	c.2405G>A	c.(2404-2406)TGC>TAC	p.C802Y	RIN2_uc010gcu.1_Missense_Mutation_p.C369Y|RIN2_uc010gcv.1_Missense_Mutation_p.C596Y	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	802	Ras-associating.				endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5						AACAGTGGTTGCACAGGAAAG	0.493000													47	151					0	0	0	0
CHRNA4	1137	broad.mit.edu	37	20	61982208	61982208	+	Silent	SNP	G	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr20:61982208G>A	uc002yes.2	-	5	733	c.555C>T	c.(553-555)GAC>GAT	p.D185D	CHRNA4_uc002yet.1_Silent_p.D9D|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Silent_p.D114D|CHRNA4_uc002yev.1_Silent_p.D9D|CHRNA4_uc010gkf.1_Silent_p.D9D	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	185	Extracellular (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	TCTTGGCCTTGTCGTAGGTCC	0.592000													27	134					0	0	0	0
C21orf99	149992	broad.mit.edu	37	21	14439208	14439208	+	RNA	SNP	A	G	G			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr21:14439208A>G	uc002yja.3	+	10		c.2726A>G				NR_026916				Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						AAGAGAAGAAATGCCAATATA	0.299000													5	15					0	0	0	0
ITPR1	3708	broad.mit.edu	37	3	4687340	4687340	+	Silent	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr3:4687340C>T	uc003bqa.2	+	10	1131	c.783C>T	c.(781-783)CAC>CAT	p.H261H	ITPR1_uc010hbz.2_Silent_p.H261H|ITPR1_uc010hca.1_Silent_p.H261H|ITPR1_uc011asu.1_Silent_p.H261H|ITPR1_uc010hcb.1_Silent_p.H261H	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	261	MIR 3.|Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AGAAGCAGCACGTCTTCCTGA	0.547000													14	8					0	0	0	0
TBC1D5	9779	broad.mit.edu	37	3	17255708	17255708	+	Silent	SNP	T	C	C			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr3:17255708T>C	uc003cbf.2	-	18	3408	c.1743A>G	c.(1741-1743)AGA>AGG	p.R581R	TBC1D5_uc010heu.2_Silent_p.R168R|TBC1D5_uc010hev.2_Silent_p.R603R|TBC1D5_uc003cbe.2_Silent_p.R581R|TBC1D5_uc010hew.1_Silent_p.R555R	NM_014744	NP_055559	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5 isoform b	581						intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						CAGATTCTTTTCTGCCCATAG	0.383000													6	18					0	0	0	0
KALRN	8997	broad.mit.edu	37	3	124281837	124281837	+	Missense_Mutation	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr3:124281837C>T	uc003ehg.2	+	34	5204	c.5077C>T	c.(5077-5079)CGG>TGG	p.R1693W	KALRN_uc003ehi.2_Missense_Mutation_p.R66W	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1693	SH3 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						TACCACCGAACGGAGCCCGCC	0.657000													43	103					0	0	0	0
SERPINI2	5276	broad.mit.edu	37	3	167189381	167189381	+	Missense_Mutation	SNP	G	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr3:167189381G>A	uc003fer.1	-	1	300	c.242C>T	c.(241-243)TCA>TTA	p.S81L	SERPINI2_uc003fes.1_Missense_Mutation_p.S91L|SERPINI2_uc003fet.1_Missense_Mutation_p.S81L	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	81					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3						CTCACCAGCTGAGGTTTCCTG	0.363000													42	127					0	0	0	0
ABCF3	55324	broad.mit.edu	37	3	183911221	183911221	+	Missense_Mutation	SNP	G	C	C	rs150420700		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr3:183911221G>C	uc003fmz.2	+	20	2085	c.1952G>C	c.(1951-1953)CGT>CCT	p.R651P	ABCF3_uc003fna.2_Missense_Mutation_p.R645P|ABCF3_uc003fnb.2_Missense_Mutation_p.R332P	NM_018358	NP_060828	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20),	651	ABC transporter 2.						ATP binding|ATPase activity			ovary(3)|lung(1)	4	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GCTCTGGGCCGTGCCCTCAAC	0.592000													37	174					0	0	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6064140	6064140	+	Missense_Mutation	SNP	G	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr4:6064140G>A	uc003giu.3	-	10	1735	c.1459C>T	c.(1459-1461)CGC>TGC	p.R487C	JAKMIP1_uc010idb.1_Missense_Mutation_p.R487C|JAKMIP1_uc010idc.1_Missense_Mutation_p.R302C|JAKMIP1_uc010idd.1_Missense_Mutation_p.R487C|JAKMIP1_uc011bwc.1_Missense_Mutation_p.R322C|JAKMIP1_uc003giv.3_Missense_Mutation_p.R487C|JAKMIP1_uc010ide.2_Missense_Mutation_p.R487C	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	487	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						TGGCAGAAGCGCAGGTCAGCC	0.532000													17	64					0	0	0	0
ABCG2	9429	broad.mit.edu	37	4	89039301	89039301	+	Silent	SNP	G	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr4:89039301G>A	uc003hrg.2	-	7	1294	c.801C>T	c.(799-801)CAC>CAT	p.H267H	ABCG2_uc003hrh.2_Silent_p.H267H|ABCG2_uc003hrf.2_Silent_p.H137H	NM_004827	NP_004818	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G, member 2	267	ABC transporter.|Cytoplasmic (Potential).				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	GAGCAGGCCCGTGGAACATAA	0.433000													22	46					0	0	0	0
NPY2R	4887	broad.mit.edu	37	4	156136031	156136031	+	Missense_Mutation	SNP	G	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr4:156136031G>A	uc003ioq.2	+	2	1435	c.940G>A	c.(940-942)GCC>ACC	p.A314T	NPY2R_uc003ior.2_Missense_Mutation_p.A314T	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	314	Helical; Name=7; (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				CCACATCATCGCCATGTGCTC	0.537000													23	45					0	0	0	0
IRF4	3662	broad.mit.edu	37	6	401688	401688	+	Missense_Mutation	SNP	A	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr6:401688A>T	uc003msz.3	+	7	1123	c.1010A>T	c.(1009-1011)GAC>GTC	p.D337V	IRF4_uc010jne.1_Missense_Mutation_p.D337V|IRF4_uc003mta.3_RNA|IRF4_uc003mtb.3_Missense_Mutation_p.D336V|IRF4_uc003mtc.1_Missense_Mutation_p.D167V	NM_002460	NP_002451	Q15306	IRF4_HUMAN	interferon regulatory factor 4	337					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		ATCTACTGGGACGGGCCCCTG	0.597000			T	IGH@	MM 								11	29					0	0	0	0
HIST1H1T	3010	broad.mit.edu	37	6	26108108	26108108	+	Missense_Mutation	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr6:26108108C>T	uc003ngj.2	-	1	257	c.214G>A	c.(214-216)GCT>ACT	p.A72T		NM_005323	NP_005314	P22492	H1T_HUMAN	histone cluster 1, H1t	72	H15.				cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			ovary(2)	2						TAGCCAGCAGCGGCCAATGCC	0.527000													29	69					0	0	0	0
OR2H2	7932	broad.mit.edu	37	6	29556136	29556136	+	Missense_Mutation	SNP	T	C	C			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr6:29556136T>C	uc003nmr.1	+	1	454	c.415T>C	c.(415-417)TGC>CGC	p.C139R	GABBR1_uc003nmp.3_Intron	NM_007160	NP_009091	O95918	OR2H2_HUMAN	olfactory receptor, family 2, subfamily H,	139	Helical; Name=4; (Potential).				defense response|mating|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCCCCGCCTGTGCTGGCAGCT	0.612000													46	230					0	0	0	0
STK19	8859	broad.mit.edu	37	6	31939881	31939881	+	Silent	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr6:31939881C>T	uc003nyv.2	+	1	236	c.108C>T	c.(106-108)ACC>ACT	p.T36T	DOM3Z_uc003nyo.1_5'UTR|DOM3Z_uc003nyp.1_5'UTR|DOM3Z_uc003nyq.1_5'UTR|DOM3Z_uc003nyr.1_5'UTR|DOM3Z_uc003nys.1_5'Flank|DOM3Z_uc010jtl.1_5'UTR|STK19_uc003nyt.2_5'UTR|DOM3Z_uc003nyu.1_5'UTR|STK19_uc011dow.1_Silent_p.T36T|STK19_uc011dox.1_5'UTR|STK19_uc003nyw.2_Silent_p.T36T|STK19_uc010jtn.1_5'Flank	NM_032454	NP_115830	P49842	STK19_HUMAN	serine/threonine kinase 19 isoform 2	36						nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			skin(4)	4						AGGTTGACACCAACGTGGCCA	0.687000													22	94					0	0	0	0
CUL9	23113	broad.mit.edu	37	6	43188224	43188224	+	Missense_Mutation	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr6:43188224C>T	uc003ouk.2	+	32	6385	c.6310C>T	c.(6310-6312)CGG>TGG	p.R2104W	CUL9_uc003oul.2_Missense_Mutation_p.R2076W|CUL9_uc010jyk.2_Missense_Mutation_p.R1256W|CUL9_uc003oun.2_5'UTR	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	2104	RING-type 1.				ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						CCTGACAACTCGGATCGAGCA	0.582000													58	183					0	0	0	0
SLC35F1	222553	broad.mit.edu	37	6	118228909	118228909	+	Missense_Mutation	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr6:118228909C>T	uc003pxx.3	+	1	221	c.20C>T	c.(19-21)CCG>CTG	p.P7L		NM_001029858	NP_001025029	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	7					transport	integral to membrane				breast(1)	1				GBM - Glioblastoma multiforme(226;0.217)		CCTGAGCAGCCGCAGCAGCAG	0.741000													7	23					0	0	0	0
CLVS2	134829	broad.mit.edu	37	6	123319012	123319012	+	Missense_Mutation	SNP	C	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr6:123319012C>A	uc003pzi.1	+	2	959	c.90C>A	c.(88-90)GAC>GAA	p.D30E		NM_001010852	NP_001010852	Q5SYC1	CLVS2_HUMAN	retinaldehyde binding protein 1-like 2	30					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						TGCACCAGGACATCCAGGAGG	0.547000													12	57					1.5842e-08	1.7564e-08	1	0
MYCT1	80177	broad.mit.edu	37	6	153019122	153019122	+	Missense_Mutation	SNP	T	C	C			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr6:153019122T>C	uc003qpd.3	+	1	93	c.85T>C	c.(85-87)TTC>CTC	p.F29L	MYCT1_uc010kjc.1_Missense_Mutation_p.F29L|MYCT1_uc003qpc.3_Missense_Mutation_p.F29L	NM_025107	NP_079383	Q8N699	MYCT1_HUMAN	myc target 1	29						nucleus				ovary(1)	1		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		ACTGCTTTTTTTCGACATACT	0.333000													6	15					0	0	0	0
C7orf25	79020	broad.mit.edu	37	7	42950018	42950018	+	Missense_Mutation	SNP	C	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr7:42950018C>A	uc003thw.2	-	2	946	c.482G>T	c.(481-483)AGC>ATC	p.S161I	C7orf25_uc010kxq.2_Missense_Mutation_p.S161I|C7orf25_uc003thx.3_Missense_Mutation_p.S219I|C7orf25_uc010kxr.2_Missense_Mutation_p.S219I	NM_024054	NP_076959	Q9BPX7	CG025_HUMAN	hypothetical protein LOC79020 b	161										skin(1)	1						GTGAGGGTTGCTATACTGCAC	0.498000													28	60					7.26314e-15	8.41864e-15	1	0
AUTS2	26053	broad.mit.edu	37	7	69364472	69364472	+	Silent	SNP	G	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr7:69364472G>A	uc003tvw.3	+	2	1253	c.510G>A	c.(508-510)AAG>AAA	p.K170K	AUTS2_uc003tvv.3_Silent_p.K170K|AUTS2_uc003tvx.3_Silent_p.K170K	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	170										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		AAATGCCGAAGGCACTCAGAC	0.517000													19	35					0	0	0	0
PON3	5446	broad.mit.edu	37	7	94993361	94993361	+	Missense_Mutation	SNP	A	G	G			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr7:94993361A>G	uc003unt.2	-	6	534	c.509T>C	c.(508-510)GTG>GCG	p.V170A	PON1_uc011kih.1_Intron|PON3_uc011kii.1_Missense_Mutation_p.V218A	NM_000940	NP_000931	Q15166	PON3_HUMAN	paraoxonase 3	170					aromatic compound catabolic process|carboxylic acid catabolic process|response to external stimulus	extracellular space	aryldialkylphosphatase activity|arylesterase activity|metal ion binding|protein homodimerization activity			ovary(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			TCCAAGAACCACAATGTCATT	0.398000													19	73					0	0	0	0
C7orf58	79974	broad.mit.edu	37	7	120773893	120773893	+	Missense_Mutation	SNP	G	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr7:120773893G>T	uc003vjq.3	+	13	2041	c.1594G>T	c.(1594-1596)GAT>TAT	p.D532Y	C7orf58_uc003vjr.1_Missense_Mutation_p.D532Y|C7orf58_uc003vjs.3_Missense_Mutation_p.D532Y|C7orf58_uc003vjt.3_Missense_Mutation_p.D312Y|C7orf58_uc010lkk.1_Missense_Mutation_p.D312Y	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	532						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					TTTCACAGAAGATAAGAACAT	0.299000													13	37					6.94344e-10	7.86924e-10	1	0
CDCA2	157313	broad.mit.edu	37	8	25364100	25364100	+	Missense_Mutation	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr8:25364100C>T	uc003xep.1	+	15	2397	c.1918C>T	c.(1918-1920)CGT>TGT	p.R640C	PPP2R2A_uc003xek.2_Intron|CDCA2_uc011lae.1_3'UTR|CDCA2_uc003xeq.1_Missense_Mutation_p.R625C|CDCA2_uc003xer.1_Missense_Mutation_p.R303C	NM_152562	NP_689775	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	640					cell division|mitosis	cytoplasm|nucleus					0		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		GGATCTTTTGCGTCATGACCC	0.363000													37	38					0	0	0	0
PRKDC	5591	broad.mit.edu	37	8	48771464	48771464	+	Silent	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr8:48771464C>T	uc003xqi.2	-	48	6348	c.6291G>A	c.(6289-6291)CTG>CTA	p.L2097L	PRKDC_uc003xqj.2_Silent_p.L2097L|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	2097					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CCAGGGCCGTCAGGGGCGCCA	0.577000								NHEJ					29	153					0	0	0	0
KCNB2	9312	broad.mit.edu	37	8	73849915	73849915	+	Silent	SNP	G	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr8:73849915G>T	uc003xzb.2	+	3	2913	c.2325G>T	c.(2323-2325)GCG>GCT	p.A775A		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	775	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			AGGTTTCAGCGCCTTGTCAGG	0.532000													47	61					6.68952e-21	7.84289e-21	1	0
CSMD3	114788	broad.mit.edu	37	8	113277798	113277798	+	Missense_Mutation	SNP	C	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr8:113277798C>A	uc003ynu.2	-	60	9689	c.9530G>T	c.(9529-9531)GGT>GTT	p.G3177V	CSMD3_uc003yns.2_Missense_Mutation_p.G2379V|CSMD3_uc003ynt.2_Missense_Mutation_p.G3137V|CSMD3_uc011lhx.1_Missense_Mutation_p.G3008V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3177	Extracellular (Potential).|Sushi 24.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGCTGGTATACCTGGGTCTCC	0.428000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			129	97					5.60598e-63	6.80726e-63	1	0
PTCH1	5727	broad.mit.edu	37	9	98209339	98209339	+	Missense_Mutation	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr9:98209339C>T	uc004avk.3	-	23	4387	c.4199G>A	c.(4198-4200)GGC>GAC	p.G1400D	PTCH1_uc010mrn.2_Missense_Mutation_p.G192D|PTCH1_uc010mro.2_Missense_Mutation_p.G1249D|PTCH1_uc010mrp.2_Missense_Mutation_p.G1249D|PTCH1_uc010mrq.2_Missense_Mutation_p.G1249D|PTCH1_uc004avl.3_Missense_Mutation_p.G1249D|PTCH1_uc010mrr.2_Missense_Mutation_p.G1334D|PTCH1_uc004avm.3_Missense_Mutation_p.G1399D	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	1400	Cytoplasmic (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				CTCAGGGTAGCCTGGGCAGAG	0.657000									Basal_Cell_Nevus_syndrome				35	127					0	0	0	0
Unknown	0	broad.mit.edu	37	9	98775218	98775218	+	Silent	SNP	A	G	G			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr9:98775218A>G	uc010msa.1	+	4	2205	c.1329A>G	c.(1327-1329)AAA>AAG	p.K443K	uc011lun.1_Intron					RecName: Full=Uncharacterized protein C9orf102;																		TGCCAAAGAAAGTTCTTTCAG	0.398000													6	12					0	0	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77913339	77913339	+	Silent	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chrX:77913339C>T	uc004edc.1	-	2	875	c.579G>A	c.(577-579)GAG>GAA	p.E193E		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	193	Pro-rich.						nucleic acid binding|zinc ion binding			ovary(1)	1						CATTTGAAGGCTCCAGAGGCT	0.537000													4	8					0	0	0	0
SEPT6	23157	broad.mit.edu	37	X	118797474	118797474	+	Silent	SNP	G	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chrX:118797474G>A	uc004erv.2	-	3	577	c.312C>T	c.(310-312)GGC>GGT	p.G104G	SEPT6_uc010nqk.2_RNA|SEPT6_uc004ers.2_Silent_p.G104G|SEPT6_uc004ert.2_Silent_p.G104G|SEPT6_uc004eru.2_Silent_p.G104G|SEPT6_uc004erw.2_Silent_p.G46G|SEPT6_uc011mtv.1_Silent_p.G46G|SEPT6_uc011mtw.1_Silent_p.G134G	NM_015129	NP_055944	Q14141	SEPT6_HUMAN	septin 6 isoform B	104		GTP; via amide nitrogen (By similarity).			cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			lung(1)|ovary(1)|prostate(1)|kidney(1)	4						GGTCCCCAAAGCCAACTGTGC	0.572000													145	116					0	0	0	0
CT47B1	643311	broad.mit.edu	37	X	120009066	120009066	+	Silent	SNP	C	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chrX:120009066C>T	uc011muc.1	-	1	714	c.459G>A	c.(457-459)GTG>GTA	p.V153V		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	153											0						CGTGGGGCCCCACCATCAGGC	0.652000													10	39					0	0	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	4968515	4968515	+	Missense_Mutation	SNP	G	T	T			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chrY:4968515G>T	uc004fqo.2	+	2	3630	c.2896G>T	c.(2896-2898)GAT>TAT	p.D966Y	PCDH11Y_uc010nwg.1_Missense_Mutation_p.D955Y|PCDH11Y_uc004fql.1_Missense_Mutation_p.D955Y|PCDH11Y_uc004fqm.1_Missense_Mutation_p.D955Y|PCDH11Y_uc004fqn.1_Missense_Mutation_p.D966Y|PCDH11Y_uc004fqp.1_Missense_Mutation_p.D737Y	NM_032973	NP_116755	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked isoform c	966	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						TGACAGCCCTGATTTGGCCCG	0.463000													106	24					2.24849e-53	2.69819e-53	1	0
Unknown	0	broad.mit.edu	37	1	31128352	31128353	+	IGR	INS	-	GAC	GAC			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:31128352_31128353insGAC								None (None upstream) : MATN1 (55773 downstream)																							gtggtgatggtggtggtggtgg	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	1	121484633	121484633	+	IGR	DEL	T	-	-	rs4898120		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:121484633delT								LOC647121 (170947 upstream) : None (None downstream)																							agagtttaacttttcttttca	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	1	149095401	149095404	+	IGR	DEL	TGCA	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:149095401_149095404delTGCA								LOC645166 (142347 upstream) : LOC388692 (184072 downstream)																							ATCGATGTCCTGCATGCAAATAAA	0.446													---	---	---							
UBE2Q1	55585	broad.mit.edu	37	1	154528354	154528360	+	Frame_Shift_Del	DEL	TATGTCC	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:154528354_154528360delTATGTCC	uc001fff.1	-	2	499_505	c.408_414delGGACATA	c.(406-414)GTGGACATAfs	p.V136fs		NM_017582	NP_060052	Q7Z7E8	UB2Q1_HUMAN	ubiquitin-conjugating enzyme E2Q	136_138							ATP binding|protein binding|ubiquitin-protein ligase activity				0	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			TCCCTTTCTTTATGTCCACCAGCCTCT	0.522													---	---	---							
Unknown	0	broad.mit.edu	37	1	158507223	158507223	+	IGR	DEL	A	-	-	rs80342507		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:158507223delA								OR10R2 (56549 upstream) : OR6Y1 (9697 downstream)																							CAGGGTTATGAAAAAAAATCT	0.383													---	---	---							
PTPN14	5784	broad.mit.edu	37	1	214557049	214557051	+	In_Frame_Del	DEL	CCT	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:214557049_214557051delCCT	uc001hkk.1	-	13	2418_2420	c.2147_2149delAGG	c.(2146-2151)GAGGCT>GCT	p.E716del	PTPN14_uc010pty.1_In_Frame_Del_p.E617del	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	716	Poly-Glu.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		GATTCTGGAGCCTCCTCCTCCTC	0.626													---	---	---							
GPR137B	7107	broad.mit.edu	37	1	236368552	236368553	+	Splice_Site	INS	-	AAGA	AAGA			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:236368552_236368553insAAGA	uc001hxq.2	+	6	1182	c.1091_splice	c.e6+2	p.G364_splice	GPR137B_uc001hxr.1_Splice_Site_p.G146_splice|GPR137B_uc009xge.2_Splice_Site	NM_003272	NP_003263	O60478	G137B_HUMAN	G protein-coupled receptor 137B							integral to plasma membrane|membrane fraction					0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.197)|Prostate(94;0.219)|Acute lymphoblastic leukemia(190;0.226)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			TCAGGGAGGGTAAGACCCTACT	0.441													---	---	---							
Unknown	0	broad.mit.edu	37	10	42384716	42384716	+	IGR	DEL	G	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr10:42384716delG								None (None upstream) : LOC441666 (442599 downstream)																							ggaatcgaatggaatcatcat	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	10	42385259	42385259	+	IGR	DEL	C	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr10:42385259delC								None (None upstream) : LOC441666 (442056 downstream)																							caaatggaatcgaatggaatc	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	10	42385261	42385261	+	IGR	DEL	A	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr10:42385261delA								None (None upstream) : LOC441666 (442054 downstream)																							aatggaatcgaatggaatcac	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	10	42385606	42385606	+	IGR	DEL	G	-	-	rs67827809		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr10:42385606delG								None (None upstream) : LOC441666 (441709 downstream)																							ggaattcaaaggaatcatcat	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	10	42392726	42392748	+	IGR	DEL	AATCGAATGGAATTATCGAATGC	-	-	rs67625628		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr10:42392726_42392748delAATCGAATGGAATTATCGAATGC								None (None upstream) : LOC441666 (434567 downstream)																							cctcaaatggaatcgaatggaattatcgaatgcaatcgaatgg	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	10	42400410	42400410	+	IGR	DEL	C	-	-	rs74186261		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr10:42400410delC								None (None upstream) : LOC441666 (426905 downstream)																							aacgggatttcttcacataat	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	10	42528030	42528030	+	IGR	DEL	G	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr10:42528030delG								None (None upstream) : LOC441666 (299285 downstream)																							attatatgaagaaatcccgtt	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	10	42596908	42596910	+	IGR	DEL	TCA	-	-	rs74210869		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr10:42596908_42596910delTCA								None (None upstream) : LOC441666 (230405 downstream)																							ggaatcatcttcaaatggaaagg	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	10	42597159	42597159	+	IGR	DEL	T	-	-	rs149908177		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr10:42597159delT								None (None upstream) : LOC441666 (230156 downstream)																							ttgaacggaatcgaatggaat	0.035													---	---	---							
Unknown	0	broad.mit.edu	37	10	42597165	42597165	+	IGR	DEL	G	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr10:42597165delG								None (None upstream) : LOC441666 (230150 downstream)																							ggaatcgaatggaatcatcat	0.020													---	---	---							
Unknown	0	broad.mit.edu	37	10	42599619	42599619	+	IGR	DEL	A	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr10:42599619delA								None (None upstream) : LOC441666 (227696 downstream)																							aaacgaatggaatcatcatcg	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	10	42599640	42599640	+	IGR	DEL	A	-	-	rs145203825		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr10:42599640delA								None (None upstream) : LOC441666 (227675 downstream)																							aatggaaatgaaaggagtcat	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	10	42600053	42600053	+	IGR	DEL	T	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr10:42600053delT								None (None upstream) : LOC441666 (227262 downstream)																							ttgaacggaattgaatggaat	0.000													---	---	---							
CCAR1	55749	broad.mit.edu	37	10	70520917	70520919	+	In_Frame_Del	DEL	GAT	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr10:70520917_70520919delGAT	uc001joo.2	+	16	2193_2195	c.2074_2076delGAT	c.(2074-2076)GATdel	p.D694del	CCAR1_uc001jol.1_RNA|CCAR1_uc001jom.1_In_Frame_Del_p.D499del|CCAR1_uc009xpx.1_In_Frame_Del_p.D668del|CCAR1_uc001jon.1_In_Frame_Del_p.D640del|CCAR1_uc010qiz.1_In_Frame_Del_p.D679del|CCAR1_uc010qja.1_In_Frame_Del_p.D679del|CCAR1_uc010qjb.1_RNA	NM_018237	NP_060707	Q8IX12	CCAR1_HUMAN	cell-cycle and apoptosis regulatory protein 1	694	Glu-rich.				apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			ovary(6)|large_intestine(1)	7						AGAGGATGAGGATGATGATAGGA	0.340													---	---	---							
CHUK	1147	broad.mit.edu	37	10	101989276	101989276	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr10:101989276delG	uc001kqp.2	-	1	69	c.14delC	c.(13-15)CCGfs	p.P5fs		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	5					I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		ccgcagccccgggggccgcTC	0.557													---	---	---							
TRPM5	29850	broad.mit.edu	37	11	2444230	2444231	+	Frame_Shift_Ins	INS	-	G	G			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr11:2444230_2444231insG	uc001lwm.3	-	1	45_46	c.36_37insC	c.(34-39)CCCGGGfs	p.P12fs	TRPM5_uc010qxl.1_Frame_Shift_Ins_p.P12fs|TRPM5_uc009ydn.2_Frame_Shift_Ins_p.P12fs	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	12_13	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		TCAGCATCCCCGGGGCTTCCGG	0.668													---	---	---							
OR4A15	81328	broad.mit.edu	37	11	55135884	55135884	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr11:55135884delG	uc010rif.1	+	1	525	c.525delG	c.(523-525)GCGfs	p.A175fs		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	175	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGCTGTTGGCGGCCTGGATTG	0.438													---	---	---							
OR8I2	120586	broad.mit.edu	37	11	55861308	55861308	+	Frame_Shift_Del	DEL	T	-	-	rs112181516		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr11:55861308delT	uc010rix.1	+	1	525	c.525delT	c.(523-525)CATfs	p.H175fs		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	175	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					GCATCAATCATTTTTTTTGTG	0.443													---	---	---							
CHEK1	1111	broad.mit.edu	37	11	125505377	125505378	+	Frame_Shift_Ins	INS	-	A	A	rs35817404		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr11:125505377_125505378insA	uc009zbo.2	+	7	1559_1560	c.667_668insA	c.(667-669)GAAfs	p.E223fs	CHEK1_uc010sbh.1_Frame_Shift_Ins_p.E239fs|CHEK1_uc010sbi.1_Frame_Shift_Ins_p.E223fs|CHEK1_uc001qcf.3_Frame_Shift_Ins_p.E223fs|CHEK1_uc009zbp.2_Frame_Shift_Ins_p.E223fs|CHEK1_uc001qcg.3_Frame_Shift_Ins_p.E223fs|CHEK1_uc009zbq.2_Frame_Shift_Ins_p.E223fs|CHEK1_uc001qci.1_RNA	NM_001114122	NP_001107594	O14757	CHK1_HUMAN	checkpoint kinase 1	223	Protein kinase.				cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|skin(1)	6	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)		TGACTGGAAAGAAAAAAAAACA	0.361								Other_conserved_DNA_damage_response_genes					---	---	---							
ERP27	121506	broad.mit.edu	37	12	15068553	15068566	+	Frame_Shift_Del	DEL	TTTAGTTTGAAAAA	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr12:15068553_15068566delTTTAGTTTGAAAAA	uc001rco.2	-	6	652_665	c.631_644delTTTTTCAAACTAAA	c.(631-645)TTTTTCAAACTAAAGfs	p.F211fs		NM_152321	NP_689534	Q96DN0	ERP27_HUMAN	endoplasmic reticulum protein 27 kDa precursor	211_215						endoplasmic reticulum lumen				breast(1)	1						TTGAGACTCCTTTAGTTTGAAAAATGATATCACC	0.421													---	---	---							
MLL2	8085	broad.mit.edu	37	12	49425978	49425978	+	Frame_Shift_Del	DEL	T	-	-	rs3741622	by1000genomes	TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr12:49425978delT	uc001rta.3	-	39	12510	c.12510delA	c.(12508-12510)CCAfs	p.P4170fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4170	Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGGGAGGTTGTGGCCCTGTAT	0.592			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---							
MARCH9	92979	broad.mit.edu	37	12	58149573	58149573	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr12:58149573delC	uc001spx.1	+	1	674	c.262delC	c.(262-264)CCCfs	p.P88fs	MARCH9_uc001spy.2_5'Flank	NM_138396	NP_612405	Q86YJ5	MARH9_HUMAN	membrane-associated RING-CH protein IX	88	Pro-rich.					Golgi membrane|Golgi stack|integral to membrane|lysosomal membrane|trans-Golgi network	ligase activity|zinc ion binding				0	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			gccgctgccgcccccgggcgc	0.507													---	---	---							
PPTC7	160760	broad.mit.edu	37	12	110977626	110977626	+	Splice_Site	DEL	C	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr12:110977626delC	uc001trh.1	-	4	954	c.726_splice	c.e4+1	p.K242_splice		NM_139283	NP_644812	Q8NI37	PPTC7_HUMAN	T-cell activation protein phosphatase 2C								metal ion binding|phosphoprotein phosphatase activity				0						GAGTTAATTACCTTTAACTTT	0.393													---	---	---							
PABPC3	5042	broad.mit.edu	37	13	25671804	25671806	+	In_Frame_Del	DEL	GCT	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr13:25671804_25671806delGCT	uc001upy.2	+	1	1529_1531	c.1468_1470delGCT	c.(1468-1470)GCTdel	p.A496del		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	496					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		ACGTCctgcagctgctgctgctg	0.414													---	---	---							
KRTAP1-5	83895	broad.mit.edu	37	17	39183012	39183012	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr17:39183012delG	uc002hvu.2	-	1	443	c.396delC	c.(394-396)CCCfs	p.P132fs		NM_031957	NP_114163	Q9BYS1	KRA15_HUMAN	keratin associated protein 1.5	132	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament					0		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			CCACACAGCAGGGGGGTAGGT	0.667													---	---	---							
LGALS3BP	3959	broad.mit.edu	37	17	76969075	76969076	+	Frame_Shift_Del	DEL	CA	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr17:76969075_76969076delCA	uc002jwh.2	-	5	784_785	c.605_606delTG	c.(604-606)GTGfs	p.V202fs	LGALS3BP_uc002jwi.2_Frame_Shift_Del_p.V8fs|LGALS3BP_uc010dhr.2_Frame_Shift_Del_p.V8fs	NM_005567	NP_005558	Q08380	LG3BP_HUMAN	galectin 3 binding protein	202	BTB.				cell adhesion|cellular defense response	extracellular space|membrane|proteinaceous extracellular matrix	protein binding|scavenger receptor activity			central_nervous_system(3)|ovary(1)	4			BRCA - Breast invasive adenocarcinoma(99;0.0677)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			TGACCATGGGCACACACTCAGC	0.624													---	---	---							
CCDC57	284001	broad.mit.edu	37	17	80173535	80173535	+	5'Flank	DEL	C	-	-	rs112012232		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr17:80173535delC	uc002kdz.1	-						CCDC57_uc002kdx.1_5'Flank	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57											ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			tccttccctgccccccacact	0.313													---	---	---							
CDH19	28513	broad.mit.edu	37	18	64212132	64212132	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr18:64212132delG	uc002lkc.1	-	6	922	c.784delC	c.(784-786)CGCfs	p.R262fs	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Frame_Shift_Del_p.R262fs|CDH19_uc002lkd.2_Frame_Shift_Del_p.R262fs	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	262	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				ACAGTCAAGCGGTATAAACCT	0.294													---	---	---							
Unknown	0	broad.mit.edu	37	19	22500220	22500220	+	IGR	DEL	T	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:22500220delT								ZNF676 (120467 upstream) : ZNF98 (73679 downstream)																							GTGGCAAAACttttttttttt	0.189													---	---	---							
Unknown	0	broad.mit.edu	37	19	27732215	27732216	+	IGR	INS	-	C	C	rs74197760		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:27732215_27732216insC								None (None upstream) : LOC148189 (549186 downstream)																							agaaaaggaaatatcttcgtat	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	19	27736453	27736453	+	IGR	DEL	T	-	-	rs4567863		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:27736453delT								None (None upstream) : LOC148189 (544949 downstream)																							tggaaacgggtttttttcttg	0.000													---	---	---							
LILRB1	10859	broad.mit.edu	37	19	55146148	55146150	+	In_Frame_Del	DEL	CTC	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:55146148_55146150delCTC	uc002qgj.2	+	11	1757_1759	c.1417_1419delCTC	c.(1417-1419)CTCdel	p.L479del	LILRB1_uc010erp.1_In_Frame_Del_p.L94del|LILRB1_uc002qgl.2_In_Frame_Del_p.L479del|LILRB1_uc002qgk.2_In_Frame_Del_p.L480del|LILRB1_uc002qgm.2_In_Frame_Del_p.L480del|LILRB1_uc010erq.2_In_Frame_Del_p.L463del|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	479	Helical; (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity	p.L479del(1)		large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		CAtcctactgctcctcctcctcc	0.458										HNSCC(37;0.09)			---	---	---							
DYSF	8291	broad.mit.edu	37	2	71801334	71801335	+	In_Frame_Ins	INS	-	AGGCGG	AGGCGG			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr2:71801334_71801335insAGGCGG	uc002sie.2	+	30	3557_3558	c.3181_3182insAGGCGG	c.(3181-3183)CAG>CAGGCGGAG	p.1065_1066insAE	DYSF_uc010feg.2_In_Frame_Ins_p.1096_1097insAE|DYSF_uc010feh.2_In_Frame_Ins_p.1051_1052insAE|DYSF_uc002sig.3_In_Frame_Ins_p.1051_1052insAE|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_In_Frame_Ins_p.1065_1066insAE|DYSF_uc010fef.2_In_Frame_Ins_p.1082_1083insAE|DYSF_uc010fei.2_In_Frame_Ins_p.1082_1083insAE|DYSF_uc010fek.2_In_Frame_Ins_p.1083_1084insAE|DYSF_uc010fej.2_In_Frame_Ins_p.1052_1053insAE|DYSF_uc010fel.2_In_Frame_Ins_p.1052_1053insAE|DYSF_uc010feo.2_In_Frame_Ins_p.1097_1098insAE|DYSF_uc010fem.2_In_Frame_Ins_p.1066_1067insAE|DYSF_uc010fen.2_In_Frame_Ins_p.1083_1084insAE|DYSF_uc002sif.2_In_Frame_Ins_p.1066_1067insAE|DYSF_uc010yqy.1_5'Flank	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1065_1066	Cytoplasmic (Potential).|Arg-rich.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						GCAGCACAGGCAGGCGGAGGCG	0.639													---	---	---							
LOXL3	84695	broad.mit.edu	37	2	74763923	74763924	+	Frame_Shift_Ins	INS	-	C	C			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr2:74763923_74763924insC	uc002smp.1	-	5	896_897	c.824_825insG	c.(823-825)GGCfs	p.G275fs	LOXL3_uc002smo.1_Intron|LOXL3_uc010ffm.1_Frame_Shift_Ins_p.G275fs|LOXL3_uc002smq.1_Intron|LOXL3_uc010ffn.1_Intron	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor	275	SRCR 2.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						CCACTGCAGGGCCCCCCCCAGG	0.649													---	---	---							
Unknown	0	broad.mit.edu	37	21	44755961	44755961	+	IGR	DEL	C	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr21:44755961delC								CRYAA (163048 upstream) : SIK1 (78437 downstream)																							accatcaccaccatcaccacc	0.000													---	---	---							
PCDHGC3	5098	broad.mit.edu	37	5	140857945	140857945	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr5:140857945delG	uc003lkv.1	+	1	2377	c.2262delG	c.(2260-2262)CCGfs	p.P754fs	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lku.1_Frame_Shift_Del_p.P754fs|PCDHGC3_uc003lkw.1_Intron	NM_002588	NP_002579	Q9UN70	PCDGK_HUMAN	protocadherin gamma subfamily C, 3 isoform 1	754	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGATGTCGCCGCACCTTTACC	0.642											OREG0016865	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---							
DSP	1832	broad.mit.edu	37	6	7542148	7542149	+	Translation_Start_Site	INS	-	A	A	rs151331814	by1000genomes	TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr6:7542148_7542149insA	uc003mxp.1	+	1					DSP_uc003mxq.1_Translation_Start_Site	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I						cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TGCCCGCCGACATGAGCTGCAA	0.718													---	---	---							
Unknown	0	broad.mit.edu	37	6	58776529	58776530	+	IGR	INS	-	A	A	rs9377903		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr6:58776529_58776530insA								GUSBL2 (488805 upstream) : None (None downstream)																							atttccaagcggatatttagag	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	6	58779178	58779179	+	IGR	INS	-	CA	CA	rs4382311		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr6:58779178_58779179insCA								GUSBL2 (491454 upstream) : None (None downstream)																							tggctgcattccacacacacgg	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	6	160132736	160132736	+	IGR	DEL	C	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr6:160132736delC								SOD2 (18383 upstream) : WTAP (15393 downstream)																							ccaccactcacactgctctga	0.000													---	---	---							
PLEC	5339	broad.mit.edu	37	8	145000951	145000953	+	Splice_Site	DEL	CCT	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr8:145000951_145000953delCCT	uc003zaf.1	-	30	4625	c.4455_splice	c.e30+1	p.E1485_splice	PLEC_uc003zab.1_Splice_Site_p.E1348_splice|PLEC_uc003zac.1_Splice_Site_p.E1352_splice|PLEC_uc003zad.2_Splice_Site_p.E1348_splice|PLEC_uc003zae.1_Splice_Site_p.E1316_splice|PLEC_uc003zag.1_Splice_Site_p.E1326_splice|PLEC_uc003zah.2_Splice_Site_p.E1334_splice|PLEC_uc003zaj.2_Splice_Site_p.E1375_splice	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1						cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						ACGGGCTGTACCTCCTCCTCCTC	0.621													---	---	---							
ZNF883	169834	broad.mit.edu	37	9	115759647	115759648	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr9:115759647_115759648insA	uc011lwy.1	-	5	2131_2132	c.892_893insT	c.(892-894)TGTfs	p.C298fs		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	298	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CAGTTTCTGACATTCATTACAT	0.376													---	---	---							
TRIM32	22954	broad.mit.edu	37	9	119460090	119460091	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr9:119460090_119460091insA	uc004bjx.2	+	2	227_228	c.69_70insA	c.(67-72)TGCATGfs	p.C23fs	ASTN2_uc004bjr.1_Intron|ASTN2_uc004bjs.1_Intron|ASTN2_uc004bjt.1_Intron|TRIM32_uc004bjw.2_Frame_Shift_Ins_p.C23fs	NM_001099679	NP_001093149	Q13049	TRI32_HUMAN	tripartite motif-containing 32	23_24	RING-type.				fat cell differentiation|innate immune response|negative regulation of apoptosis|negative regulation of fibroblast proliferation|positive regulation of cell cycle|positive regulation of cell growth|positive regulation of cell migration|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein catabolic process|positive regulation of proteolysis|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to tumor necrosis factor|response to UV	nucleus	myosin binding|protein self-association|RNA binding|Tat protein binding|transcription coactivator activity|translation initiation factor binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|kidney(1)	3						GCCCCATCTGCATGGAGTCCTT	0.554									Bardet-Biedl_syndrome				---	---	---							
NOTCH1	4851	broad.mit.edu	37	9	139418227	139418228	+	Frame_Shift_Ins	INS	-	C	C			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr9:139418227_139418228insC	uc004chz.2	-	3	344_345	c.344_345insG	c.(343-345)GGCfs	p.G115fs		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	115	Extracellular (Potential).|EGF-like 3.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGTCGCAGGTGCCCCCGTTGCG	0.688			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---							
AFF2	2334	broad.mit.edu	37	X	148038070	148038070	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chrX:148038070delC	uc004fcp.2	+	11	2974	c.2495delC	c.(2494-2496)GCCfs	p.A832fs	AFF2_uc004fcq.2_Frame_Shift_Del_p.A822fs|AFF2_uc004fcr.2_Frame_Shift_Del_p.A793fs|AFF2_uc011mxb.1_Frame_Shift_Del_p.A797fs|AFF2_uc004fcs.2_Frame_Shift_Del_p.A799fs|AFF2_uc011mxc.1_Frame_Shift_Del_p.A473fs	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	832					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					AAGGAGACTGCCACAAAACCC	0.527													---	---	---							
Unknown	0	broad.mit.edu	37	Y	13842715	13842715	+	IGR	DEL	G	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chrY:13842715delG								None (None upstream) : TTTY15 (931583 downstream)																							atcaacccgagtggaatggaa	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	Y	58827381	58827381	+	IGR	DEL	A	-	-			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chrY:58827381delA								None (None upstream) : None (None downstream)																							tttccattccatttgatttga	0.000													---	---	---							
