Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
AGRN	375790	broad.mit.edu	37	1	978800	978800	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:978800C>T	uc001ack.1	+	8	1616	c.1566C>T	c.(1564-1566)CTC>CTT	p.L522L		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	522	Kazal-like 5.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CCTGTACCCTCGGGCGGGAGA	0.682000													5	16					0	0	0	0
PER3	8863	broad.mit.edu	37	1	7896001	7896001	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:7896001G>C	uc001aoo.2	+	19	3542	c.3367G>C	c.(3367-3369)GAG>CAG	p.E1123Q	PER3_uc001aop.2_Missense_Mutation_p.E1132Q|PER3_uc010nzw.1_Missense_Mutation_p.E812Q	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	1123	CRY binding domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGGTACCTGAGAGGTAAGA	0.313000													4	39					0	0	0	0
LOC440563	440563	broad.mit.edu	37	1	13183780	13183780	+	Silent	SNP	A	C	C	rs116484938	by1000genomes	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:13183780A>C	uc010obg.1	-	1	188	c.93T>G	c.(91-93)TCT>TCG	p.S31S		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	31						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						CCTCCACATCAGATTTCTTGA	0.468000													4	54					0	0	0	0
FBXO42	54455	broad.mit.edu	37	1	16641805	16641805	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:16641805C>G	uc001ayg.2	-	2	325	c.109G>C	c.(109-111)GAG>CAG	p.E37Q	FBXO42_uc001ayf.2_5'UTR|FBXO42_uc001ayh.2_Missense_Mutation_p.E37Q	NM_018994	NP_061867	Q6P3S6	FBX42_HUMAN	F-box protein 42	37										upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		TCCTCAGCCTCCAATACTGGG	0.498000													5	52					0	0	0	0
PADI2	11240	broad.mit.edu	37	1	17397918	17397918	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:17397918C>T	uc001baf.2	-	14	1700	c.1618G>A	c.(1618-1620)GAG>AAG	p.E540K	PADI2_uc010ocm.1_Missense_Mutation_p.E424K	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	540					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	TACAGGTTCTCCTGCACAAGG	0.597000													15	39					0	0	0	0
PADI4	23569	broad.mit.edu	37	1	17662722	17662722	+	Splice_Site	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:17662722G>A	uc001baj.2	+	4	436	c.408_splice	c.e4+1	p.Q136_splice	PADI4_uc009vpc.2_Splice_Site_p.Q136_splice	NM_012387	NP_036519	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV						chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	GAAAGATCAGGTACCACTCAC	0.547000											OREG0013149	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	26					0	0	0	0
ALDH4A1	8659	broad.mit.edu	37	1	19204081	19204081	+	Silent	SNP	G	A	A	rs150927009		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:19204081G>A	uc001bbb.2	-	10	1242	c.966C>T	c.(964-966)TTC>TTT	p.F322F	ALDH4A1_uc010ocu.1_Silent_p.F262F|ALDH4A1_uc001bbc.2_Silent_p.F322F	NM_170726	NP_733844	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4A1 isoform a precursor	322					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	AGCGGTGCACGAAGTGGAAGT	0.657000													7	17					0	0	0	0
TMCO4	255104	broad.mit.edu	37	1	20107215	20107215	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:20107215G>C	uc001bcn.2	-	4	279	c.37C>G	c.(37-39)CAG>GAG	p.Q13E	TMCO4_uc001bcm.2_Missense_Mutation_p.Q13E|TMCO4_uc001bco.1_Missense_Mutation_p.Q13E|TMCO4_uc001bcp.1_Missense_Mutation_p.Q13E|TMCO4_uc009vpn.1_Missense_Mutation_p.Q13E|TMCO4_uc001bcq.1_Missense_Mutation_p.Q13E	NM_181719	NP_859070	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	13						integral to membrane					0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)		AGAGGCTGCTGAGGCAGCCTC	0.498000													7	29					0	0	0	0
TMEM57	55219	broad.mit.edu	37	1	25810760	25810760	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:25810760G>A	uc001bkk.2	+	7	1510	c.1308G>A	c.(1306-1308)CAG>CAA	p.Q436Q	TMEM57_uc009vru.2_Silent_p.Q209Q|TMEM57_uc009vrv.2_Silent_p.Q78Q	NM_018202	NP_060672	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	436						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part					0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)		AGCTGCTGCAGAACAAGTACG	0.572000													15	40					0	0	0	0
AHDC1	27245	broad.mit.edu	37	1	27875878	27875878	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:27875878C>T	uc009vsy.2	-	6	3718	c.2749G>A	c.(2749-2751)GCG>ACG	p.A917T	AHDC1_uc009vsz.1_Missense_Mutation_p.A917T	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	917							DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GTCTGGCGCGCGGACAGGACA	0.697000													16	43					0	0	0	0
MACF1	23499	broad.mit.edu	37	1	39749116	39749116	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:39749116A>G	uc010ois.1	+	10	1064	c.859A>G	c.(859-861)ATC>GTC	p.I287V	MACF1_uc001cda.1_Missense_Mutation_p.I195V	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	287	Actin-binding.|CH 2.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AAAGTCTGTAATCACTTATGT	0.418000													13	37					0	0	0	0
PABPC4	8761	broad.mit.edu	37	1	40027815	40027815	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:40027815C>T	uc010oiv.1	-	14	2673	c.1775G>A	c.(1774-1776)GGA>GAA	p.G592E	PPIEL_uc001cdk.2_5'Flank|PABPC4_uc001cdl.2_Missense_Mutation_p.G608E|PABPC4_uc001cdm.2_Missense_Mutation_p.G579E	NM_003819	NP_003810	Q13310	PABP4_HUMAN	poly A binding protein, cytoplasmic 4 isoform 2	592	PABC.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CAGCAGCATTCCCGTGATCTT	0.498000													7	28					0	0	0	0
LEPR	3953	broad.mit.edu	37	1	66101929	66101929	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:66101929C>A	uc001dci.2	+	20	2931	c.2729C>A	c.(2728-2730)CCT>CAT	p.P910H	LEPR_uc009waq.2_3'UTR	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	910	Cytoplasmic (Potential).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		ACATGTGGTCCTCTTCTTTTG	0.348000													39	96					7.63091e-17	1.47118e-16	1	0
ZNF326	284695	broad.mit.edu	37	1	90459386	90459386	+	5'Flank	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:90459386C>T	uc001dnq.2	+						GEMIN8P4_uc001dno.2_RNA|ZNF326_uc001dnp.3_5'Flank|ZNF326_uc009wda.1_5'Flank|ZNF326_uc001dnr.2_5'Flank	NM_182976	NP_892021	Q5BKZ1	ZN326_HUMAN	zinc finger protein 326 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	DNA binding			ovary(1)	1		all_lung(203;0.0116)|Lung NSC(277;0.0417)		all cancers(265;0.00728)|Epithelial(280;0.0265)		TCAGGCGCTCCGCATCCAGCT	0.602000													22	38					0	0	0	0
CHI3L2	1117	broad.mit.edu	37	1	111777615	111777615	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:111777615G>C	uc001eam.2	+	5	487	c.416G>C	c.(415-417)GGA>GCA	p.G139A	CHI3L2_uc001ean.2_Missense_Mutation_p.G129A|CHI3L2_uc001eao.2_Missense_Mutation_p.G60A|CHI3L2_uc009wga.2_Missense_Mutation_p.G60A	NM_004000	NP_003991	Q15782	CH3L2_HUMAN	chitinase 3-like 2 isoform a	139					chitin catabolic process	extracellular space	cation binding|chitinase activity			central_nervous_system(1)	1		all_cancers(81;1.89e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0171)|Colorectal(144;0.0387)|all cancers(265;0.0464)|LUSC - Lung squamous cell carcinoma(189;0.0872)|Epithelial(280;0.0994)|COAD - Colon adenocarcinoma(174;0.141)		AACTTTGATGGACTGGATGTA	0.398000													4	43					0	0	0	0
PSMD4	5710	broad.mit.edu	37	1	151237665	151237665	+	Silent	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:151237665C>G	uc001exl.2	+	5	455	c.393C>G	c.(391-393)CTC>CTG	p.L131L	PSMD4_uc001exn.2_Silent_p.L131L	NM_002810	NP_002801	P55036	PSMD4_HUMAN	proteasome 26S non-ATPase subunit 4	131	VWFA.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding|zinc ion binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CTAAACGCCTCAAGAAGGAGA	0.443000													3	47					0	0	0	0
FLG2	388698	broad.mit.edu	37	1	152327481	152327481	+	Silent	SNP	A	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:152327481A>G	uc001ezw.3	-	3	2854	c.2781T>C	c.(2779-2781)TCT>TCC	p.S927S	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	927	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACTTGAGCCAGAACCATGTT	0.488000													498	306					0	0	0	0
ILF2	3608	broad.mit.edu	37	1	153636573	153636573	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:153636573C>G	uc001fcr.2	-	10	771	c.690G>C	c.(688-690)TTG>TTC	p.L230F	ILF2_uc010pdy.1_Missense_Mutation_p.L192F|ILF2_uc009wok.2_Missense_Mutation_p.L208F	NM_004515	NP_004506	Q12905	ILF2_HUMAN	interleukin enhancer binding factor 2	230	DZF.				immune response|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|ribonucleoprotein complex	ATP binding|DNA binding|double-stranded RNA binding|protein binding|transferase activity				0	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			AACGAATCCTCAAGTCCTTCA	0.398000													6	33					0	0	0	0
IL6R	3570	broad.mit.edu	37	1	154437818	154437818	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:154437818T>G	uc001fez.1	+	10	1806	c.1369T>G	c.(1369-1371)TAT>GAT	p.Y457D	IL6R_uc001ffa.1_3'UTR	NM_000565	NP_000556	P08887	IL6RA_HUMAN	interleukin 6 receptor isoform 1 precursor	457	Cytoplasmic (Potential).				acute-phase response|ciliary neurotrophic factor-mediated signaling pathway|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|endocrine pancreas development|hepatic immune response|negative regulation of collagen biosynthetic process|negative regulation of interleukin-8 production|positive regulation of activation of Janus kinase activity|positive regulation of anti-apoptosis|positive regulation of chemokine production|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of leukocyte chemotaxis|positive regulation of MAPKKK cascade|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of apoptosis	apical plasma membrane|basolateral plasma membrane|extracellular space|interleukin-6 receptor complex	ciliary neurotrophic factor binding|enzyme binding|protein homodimerization activity			ovary(3)|breast(1)	4	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			ACGGAGCCCTTATGACATCAG	0.577000													7	128					0	0	0	0
PMVK	10654	broad.mit.edu	37	1	154898882	154898882	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:154898882G>A	uc001ffq.2	-	4	713	c.390C>T	c.(388-390)CGC>CGT	p.R130R		NM_006556	NP_006547	Q15126	PMVK_HUMAN	phosphomevalonate kinase	130				R->M: Approximately 4-fold decrease in Vmax for MgATP and R-MVP. Approximately 3-fold increase in Km for MgATP and R- MVP.	cholesterol biosynthetic process|protein phosphorylation	cytosol|peroxisome	ATP binding|phosphomevalonate kinase activity|protein binding				0	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.142)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			ACGCTACAACGCGGACCGTCT	0.627000													7	73					0	0	0	0
CCT3	7203	broad.mit.edu	37	1	156290786	156290786	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:156290786C>G	uc001fol.1	-	7	673	c.453G>C	c.(451-453)ATG>ATC	p.M151I	CCT3_uc001fom.1_Missense_Mutation_p.M150I|CCT3_uc001fon.1_Missense_Mutation_p.M113I|CCT3_uc010phj.1_Missense_Mutation_p.M105I|CCT3_uc010phk.1_Missense_Mutation_p.M105I|CCT3_uc010phl.1_Missense_Mutation_p.M105I	NM_005998	NP_005989	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 isoform a	151					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					TGTTCAGCATCATATCACTGT	0.423000													8	109					0	0	0	0
SPTA1	6708	broad.mit.edu	37	1	158641861	158641861	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:158641861C>G	uc001fst.1	-	11	1675	c.1476G>C	c.(1474-1476)ATG>ATC	p.M492I		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	492	Spectrin 6.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CTTGTCTACTCATCCAACTGT	0.498000													27	116					0	0	0	0
FCRLA	84824	broad.mit.edu	37	1	161681748	161681748	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:161681748G>C	uc001gbe.2	+	5	835	c.593G>C	c.(592-594)AGA>ACA	p.R198T	FCRLA_uc001gbd.2_Missense_Mutation_p.R192T|FCRLA_uc001gbf.2_Missense_Mutation_p.R103T|FCRLA_uc001gbg.2_Missense_Mutation_p.R52T|FCRLA_uc009wuo.2_Missense_Mutation_p.R58T|FCRLA_uc009wup.2_Intron|FCRLA_uc009wuq.2_Intron	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	175	Ig-like C2-type 2.				cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			CCAATTCTCAGAGCTGTACCC	0.527000													5	443					0	0	0	0
C1orf114	57821	broad.mit.edu	37	1	169391472	169391472	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:169391472G>C	uc001gga.1	-	3	365	c.197C>G	c.(196-198)TCT>TGT	p.S66C	C1orf114_uc001gfz.1_Missense_Mutation_p.S66C|C1orf114_uc009wvq.1_Missense_Mutation_p.S66C|C1orf114_uc001ggb.2_Missense_Mutation_p.S66C|C1orf114_uc001ggc.1_Missense_Mutation_p.S66C	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	66											0	all_hematologic(923;0.208)					GTCAGGATCAGAATGCCGTTT	0.378000													8	84					0	0	0	0
TDRD5	163589	broad.mit.edu	37	1	179562647	179562647	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:179562647G>A	uc001gnf.1	+	3	535	c.285G>A	c.(283-285)AGG>AGA	p.R95R	TDRD5_uc010pnp.1_Silent_p.R95R	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	95	Lotus/OST-HTH 1.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						CAAAACAGAGGAGCAGCCATA	0.438000													15	43					0	0	0	0
TPR	7175	broad.mit.edu	37	1	186312565	186312565	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:186312565C>T	uc001grv.2	-	27	3940	c.3643G>A	c.(3643-3645)GAG>AAG	p.E1215K		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	1215	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TGAGCCACCTCAAACCTAGTT	0.353000			T	NTRK1	papillary thyroid								20	99					0	0	0	0
CFH	3075	broad.mit.edu	37	1	196709904	196709904	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:196709904C>T	uc001gtj.3	+	18	3178	c.2938C>T	c.(2938-2940)CAC>TAC	p.H980Y		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	980	Sushi 16.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						AAAATGGTCTCACCCTCCATC	0.338000													8	113					0	0	0	0
CFHR2	3080	broad.mit.edu	37	1	196920100	196920100	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:196920100G>A	uc001gtq.1	+	3	449	c.372G>A	c.(370-372)GAG>GAA	p.E124E	CFHR2_uc001gtr.1_Intron	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	124	Sushi 2.					extracellular region				skin(2)|ovary(1)	3						AAAACAATGAGAACAACATTT	0.393000													13	120					0	0	0	0
CRB1	23418	broad.mit.edu	37	1	197298069	197298069	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:197298069G>A	uc001gtz.2	+	2	723	c.588G>A	c.(586-588)AAG>AAA	p.K196K	CRB1_uc010poz.1_Silent_p.K127K|CRB1_uc001gty.1_Silent_p.K196K|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Silent_p.K196K|CRB1_uc010ppb.1_Silent_p.K196K	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	196	Extracellular (Potential).|EGF-like 5; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						ATCCCTGCAAGAACGAGGCTA	0.448000													4	68					0	0	0	0
PPP1R12B	4660	broad.mit.edu	37	1	202457699	202457699	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:202457699C>G	uc001gya.1	+	14	2033	c.1889C>G	c.(1888-1890)TCT>TGT	p.S630C	PPP1R12B_uc001gxz.1_Missense_Mutation_p.S630C|PPP1R12B_uc001gyb.1_5'UTR|PPP1R12B_uc001gyc.1_5'UTR	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)	630					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)			GAAGCAGAGTCTTTACGGAAA	0.433000													41	24					0	0	0	0
KLHL12	59349	broad.mit.edu	37	1	202863774	202863774	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:202863774C>G	uc001gyo.1	-	9	1439	c.1239G>C	c.(1237-1239)CAG>CAC	p.Q413H	KLHL12_uc001gym.1_Missense_Mutation_p.Q146H|KLHL12_uc001gyn.1_Missense_Mutation_p.Q263H|KLHL12_uc010pqc.1_Missense_Mutation_p.Q451H|KLHL12_uc009xah.1_Missense_Mutation_p.Q312H	NM_021633	NP_067646	Q53G59	KLH12_HUMAN	kelch-like 12	413	Kelch 3.|Interaction with DVL3.				Wnt receptor signaling pathway		protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.166)			CCCGGGCTGTCTGCATATCTC	0.527000													28	262					0	0	0	0
CHIT1	1118	broad.mit.edu	37	1	203186208	203186208	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:203186208G>A	uc001gzn.2	-	11	1306	c.1210C>T	c.(1210-1212)CAG>TAG	p.Q404*	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_Intron|CHIT1_uc009xal.1_Nonsense_Mutation_p.Q166*|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Nonsense_Mutation_p.Q395*	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	404					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						TCAGAGGGCTGACCTGGTTTT	0.567000											OREG0014113	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	122					0	0	0	0
FMOD	2331	broad.mit.edu	37	1	203316510	203316510	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:203316510C>T	uc001gzr.2	-	2	1025	c.889G>A	c.(889-891)GAG>AAG	p.E297K	FMOD_uc010pqi.1_RNA	NM_002023	NP_002014	Q06828	FMOD_HUMAN	fibromodulin precursor	297	LRR 9.				transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				ovary(2)|breast(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.171)			AGGTCTAGCTCAAGGAGGCTG	0.557000													114	105					0	0	0	0
REN	5972	broad.mit.edu	37	1	204128555	204128555	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:204128555C>G	uc001haq.2	-	5	705	c.661G>C	c.(661-663)GAG>CAG	p.E221Q		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	221					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	AAGACGTCCTCTTTTAGCACC	0.562000													18	104					0	0	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204400897	204400897	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:204400897C>G	uc001haw.2	-	29	4659	c.4180G>C	c.(4180-4182)GAG>CAG	p.E1394Q	PIK3C2B_uc010pqv.1_Missense_Mutation_p.E1366Q	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	1394	PX.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			TGAGTGTTCTCTCGCATCACC	0.532000											OREG0014134	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	275					0	0	0	0
SLC41A1	254428	broad.mit.edu	37	1	205779410	205779410	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:205779410G>A	uc001hdh.1	-	2	1032	c.160C>T	c.(160-162)CGG>TGG	p.R54W		NM_173854	NP_776253	Q8IVJ1	S41A1_HUMAN	solute carrier family 41 member 1	54						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			skin(2)	2	Breast(84;0.0799)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			GCGTTGGCCCGAGACTCAATC	0.652000											OREG0014163	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	99					0	0	0	0
CR1	1378	broad.mit.edu	37	1	207741206	207741206	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:207741206G>A	uc001hfy.2	+	17	2780	c.2640G>A	c.(2638-2640)GGG>GGA	p.G880G	CR1_uc009xcl.1_Silent_p.G430G|CR1_uc001hfx.2_Silent_p.G1330G|CR1_uc009xck.1_Silent_p.G430G	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	880	Extracellular (Potential).|Sushi 14.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						TTCCTAATGGGAGACACACAG	0.433000													10	367					0	0	0	0
LIN9	286826	broad.mit.edu	37	1	226474137	226474137	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:226474137C>G	uc001hqa.2	-	6	779	c.469G>C	c.(469-471)GAC>CAC	p.D157H	LIN9_uc001hqb.2_Missense_Mutation_p.D122H|LIN9_uc001hqc.2_Missense_Mutation_p.D89H|LIN9_uc009xel.1_Missense_Mutation_p.D122H	NM_173083	NP_775106	Q5TKA1	LIN9_HUMAN	lin-9 homolog	141	Sufficient for interaction with RB1.				cell cycle|DNA replication	nucleoplasm					0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		ACACAGAAGTCATTATCACCT	0.318000													24	63					0	0	0	0
OBSCN	84033	broad.mit.edu	37	1	228432256	228432256	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:228432256C>T	uc009xez.1	+	11	3509	c.3465C>T	c.(3463-3465)TTC>TTT	p.F1155F	OBSCN_uc001hsn.2_Silent_p.F1155F	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1155	Ig-like 11.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GAGTCTCCTTCCACCTGCACA	0.542000													11	196					0	0	0	0
OBSCN	84033	broad.mit.edu	37	1	228556503	228556503	+	Silent	SNP	A	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:228556503A>G	uc009xez.1	+	89	19892	c.19848A>G	c.(19846-19848)CCA>CCG	p.P6616P	OBSCN_uc001hsr.1_Silent_p.P1245P	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6616	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				ACATCACCCCAGCAGAGCTGC	0.567000													158	98					0	0	0	0
TRIM67	440730	broad.mit.edu	37	1	231335933	231335933	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:231335933C>T	uc009xfn.1	+	4	1345	c.1303C>T	c.(1303-1305)CGT>TGT	p.R435C		NM_001004342	NP_001004342	Q6ZTA4	TRI67_HUMAN	tripartite motif-containing 67	435						cytoplasm|cytoskeleton	zinc ion binding			ovary(2)|breast(1)|kidney(1)	4	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				ATTGAAGCTGCGTCAGTCCAC	0.532000													14	219					0	0	0	0
FMN2	56776	broad.mit.edu	37	1	240371390	240371390	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:240371390G>A	uc010pyd.1	+	5	3503	c.3278G>A	c.(3277-3279)GGA>GAA	p.G1093E	FMN2_uc010pye.1_Missense_Mutation_p.G1097E	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1093	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCTCTACCCGGAGCGGGCATA	0.726000													3	9					0	0	0	0
AHCTF1	25909	broad.mit.edu	37	1	247040301	247040301	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:247040301T>C	uc001ibu.1	-	22	2895	c.2888A>G	c.(2887-2889)AAT>AGT	p.N963S	AHCTF1_uc001ibv.1_Missense_Mutation_p.N972S|AHCTF1_uc009xgs.1_5'UTR|AHCTF1_uc001ibw.1_RNA	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	963	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			AGGCACATAATTGGCACGCTG	0.378000													12	79					0	0	0	0
OR2L3	391192	broad.mit.edu	37	1	248224496	248224496	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:248224496G>T	uc001idx.1	+	1	513	c.513G>T	c.(511-513)AGG>AGT	p.R171S	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GCCAATCCAGGGCCATCAATC	0.473000													32	219					1.74807e-11	3.30077e-11	1	0
LYZL1	84569	broad.mit.edu	37	10	29599073	29599073	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr10:29599073C>T	uc001iul.2	+	4	528	c.471C>T	c.(469-471)ATC>ATT	p.I157I		NM_032517	NP_115906	Q6UWQ5	LYZL1_HUMAN	lysozyme-like 1	111					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0		Breast(68;0.203)				ATGCAATTATCTGTGCCAGGA	0.433000													12	30					0	0	0	0
ANK3	288	broad.mit.edu	37	10	62149197	62149197	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr10:62149197C>T	uc001jky.2	-	1	292	c.100G>A	c.(100-102)GAT>AAT	p.D34N	ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jlb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	34					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TTCTTCCGATCCCGGGACCGT	0.408000													15	60					0	0	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72500862	72500862	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr10:72500862C>T	uc001jrh.2	+	12	1868	c.1868C>T	c.(1867-1869)TCC>TTC	p.S623F	ADAMTS14_uc001jrg.2_Missense_Mutation_p.S626F|ADAMTS14_uc001jri.1_Missense_Mutation_p.S146F	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	623	Cys-rich.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						AAGCGCAACTCCTACTATGTG	0.617000													13	33					0	0	0	0
C10orf58	84293	broad.mit.edu	37	10	82187156	82187156	+	Nonsense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr10:82187156C>G	uc001kcc.3	+	5	640	c.480C>G	c.(478-480)TAC>TAG	p.Y160*	C10orf58_uc001kcd.3_Nonsense_Mutation_p.Y149*|C10orf58_uc001kce.3_Nonsense_Mutation_p.Y160*|C10orf58_uc001kcf.3_Nonsense_Mutation_p.Y160*	NM_032333	NP_115709	Q9BRX8	CJ058_HUMAN	hypothetical protein LOC84293 precursor	160						extracellular region					0			Colorectal(32;0.229)			GAGTGTGGTACAACTTCTTCC	0.488000													4	61					0	0	0	0
PLCE1	51196	broad.mit.edu	37	10	95892130	95892130	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr10:95892130C>T	uc001kjk.2	+	3	2040	c.1406C>T	c.(1405-1407)TCT>TTT	p.S469F	PLCE1_uc010qnx.1_Missense_Mutation_p.S469F|PLCE1_uc001kjm.2_Missense_Mutation_p.S161F	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	469					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				ATCACCGGTTCTCTCCTAGAA	0.478000													7	94					0	0	0	0
ENTPD7	57089	broad.mit.edu	37	10	101451214	101451214	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr10:101451214G>A	uc001kqa.3	+	8	960	c.782G>A	c.(781-783)GGA>GAA	p.G261E	ENTPD7_uc009xwl.2_Missense_Mutation_p.G263E	NM_020354	NP_065087	Q9NQZ7	ENTP7_HUMAN	ectonucleoside triphosphate diphosphohydrolase	261	Vesicular (Potential).					cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)		GATATGGGAGGAGCCTCTCTC	0.453000													7	37					0	0	0	0
PNLIPRP2	5408	broad.mit.edu	37	10	118394400	118394400	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr10:118394400A>T	uc001lcq.2	+	11	892	c.869A>T	c.(868-870)TAC>TTC	p.Y290F	PNLIPRP2_uc009xyu.1_RNA|PNLIPRP2_uc009xyv.1_RNA	NM_005396	NP_005387	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2	289					galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)		TTCGAGTATTACTCAAGCAGC	0.498000													7	34					0	0	0	0
PHRF1	57661	broad.mit.edu	37	11	587346	587346	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr11:587346C>G	uc001lqe.2	+	4	433	c.302C>G	c.(301-303)TCT>TGT	p.S101C	PHRF1_uc010qwc.1_Missense_Mutation_p.S101C|PHRF1_uc010qwd.1_Missense_Mutation_p.S100C|PHRF1_uc010qwe.1_Missense_Mutation_p.S97C	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	101							RNA polymerase binding|zinc ion binding				0						TCTTTCAATTCTGATGATGAT	0.562000													17	31					0	0	0	0
MUC5B	727897	broad.mit.edu	37	11	1157901	1157901	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr11:1157901G>A	uc009ycr.1	+	9	1094	c.968G>A	c.(967-969)GGG>GAG	p.G323E		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	314					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CATGCAGGGGGGTTGCCCCAG	0.667000													10	31					0	0	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137497	40137497	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr11:40137497C>T	uc001mxa.1	-	2	2310	c.346G>A	c.(346-348)GAA>AAA	p.E116K	LRRC4C_uc001mxc.1_Missense_Mutation_p.E112K|LRRC4C_uc001mxd.1_Missense_Mutation_p.E112K|LRRC4C_uc001mxb.1_Missense_Mutation_p.E112K	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	116	LRR 2.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GCCCCAATTTCAATGGTTCTG	0.428000													11	58					0	0	0	0
OR5AR1	219493	broad.mit.edu	37	11	56431302	56431302	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr11:56431302C>G	uc010rjm.1	+	1	141	c.141C>G	c.(139-141)ATC>ATG	p.I47M		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	47	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTATGATTATCCTGATTACAA	0.473000													10	183					0	0	0	0
NRXN2	9379	broad.mit.edu	37	11	64428240	64428240	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr11:64428240G>A	uc001oar.2	-	11	2609	c.2170C>T	c.(2170-2172)CGG>TGG	p.R724W	NRXN2_uc001oas.2_Missense_Mutation_p.R693W|NRXN2_uc001oaq.2_Missense_Mutation_p.R391W	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:Variant_position_missing_in_P58401_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						TCACAGACCCGCCCAAGAAAG	0.592000													17	45					0	0	0	0
RELT	84957	broad.mit.edu	37	11	73106303	73106303	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr11:73106303G>A	uc001otv.2	+	10	1383	c.1218G>A	c.(1216-1218)CTG>CTA	p.L406L	RELT_uc001otw.2_Silent_p.L406L|RELT_uc001otx.2_RNA	NM_152222	NP_689408	Q969Z4	TR19L_HUMAN	RELT tumor necrosis factor receptor precursor	406	Cytoplasmic (Potential).					cytoplasm|integral to membrane|plasma membrane	binding|receptor activity			upper_aerodigestive_tract(1)	1						CAAAGTGGCTGAAGCCCCCAG	0.642000													5	105					0	0	0	0
SLC36A4	120103	broad.mit.edu	37	11	92918982	92918982	+	Splice_Site	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr11:92918982T>A	uc001pdn.2	-	2	153	c.56_splice	c.e2-1	p.D19_splice	SLC36A4_uc001pdm.2_Splice_Site	NM_152313	NP_689526	Q6YBV0	S36A4_HUMAN	solute carrier family 36 (proton/amino acid						L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CATCCATATCTTTAAAAAAGA	0.333000													9	13					0	0	0	0
IL10RA	3587	broad.mit.edu	37	11	117864051	117864051	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr11:117864051G>T	uc001prv.2	+	4	540	c.463G>T	c.(463-465)GAC>TAC	p.D155Y	IL10RA_uc010rxl.1_Missense_Mutation_p.D135Y|IL10RA_uc010rxm.1_Missense_Mutation_p.D135Y|IL10RA_uc010rxn.1_Missense_Mutation_p.D6Y|IL10RA_uc001prw.2_Missense_Mutation_p.D6Y	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor	155	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		CCCCGCAAATGACACATATGA	0.527000													4	38					0.00024832	0.000452902	1	0
YARS2	51067	broad.mit.edu	37	12	32908286	32908286	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:32908286C>A	uc001rli.2	-	1	589	c.523G>T	c.(523-525)GCC>TCC	p.A175S		NM_001040436	NP_001035526	Q9Y2Z4	SYYM_HUMAN	tyrosyl-tRNA synthetase 2, mitochondrial	175					tyrosyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|RNA binding|tyrosine-tRNA ligase activity				0	Lung NSC(5;2.43e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)				L-Tyrosine(DB00135)	TGGTACCAGGCCGAGTTGTCC	0.657000											OREG0021729	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	22					0.000566183	0.00102681	1	0
DDN	23109	broad.mit.edu	37	12	49392252	49392252	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:49392252C>G	uc001rsv.1	-	2	425	c.407G>C	c.(406-408)CGA>CCA	p.R136P	uc001rsw.2_5'UTR	NM_015086	NP_055901	O94850	DEND_HUMAN	dendrin	136						dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				large_intestine(1)	1						GGGGCTCCGTCGGGCCCCACC	0.741000													6	13					0	0	0	0
SLC4A8	9498	broad.mit.edu	37	12	51851325	51851325	+	Splice_Site	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:51851325T>C	uc001rys.1	+	6	941	c.763_splice	c.e6+2	p.G255_splice	SLC4A8_uc010sni.1_Splice_Site_p.G202_splice|SLC4A8_uc001rym.2_Splice_Site_p.G202_splice|SLC4A8_uc001ryn.2_Splice_Site_p.G202_splice|SLC4A8_uc001ryo.2_Splice_Site_p.G202_splice|SLC4A8_uc001ryp.1_Splice_Site_p.G202_splice|SLC4A8_uc010snj.1_Splice_Site_p.G282_splice|SLC4A8_uc001ryq.3_Splice_Site_p.G255_splice|SLC4A8_uc001ryr.2_Splice_Site_p.G255_splice|SLC4A8_uc010snk.1_Splice_Site_p.G202_splice	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate						bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		ATAAACATGGTAAGATTATTA	0.388000													17	33					0	0	0	0
SCN8A	6334	broad.mit.edu	37	12	52201213	52201213	+	Nonstop_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:52201213G>C	uc001ryw.2	+	27	6121	c.5943G>C	c.(5941-5943)TAG>TAC	p.*1981Y	uc001rzb.1_5'Flank	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1981					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CCAAGTGTTAGAGGAGAACAA	0.393000													2	4					0	0	0	0
GLI1	2735	broad.mit.edu	37	12	57863427	57863427	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:57863427C>G	uc001snx.2	+	11	1600	c.1522C>G	c.(1522-1524)CAA>GAA	p.Q508E	GLI1_uc009zpq.2_Missense_Mutation_p.Q380E	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	508					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			CCAGCTACATCAACTCCGGCC	0.607000													10	60					0	0	0	0
SYT1	6857	broad.mit.edu	37	12	79689943	79689943	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:79689943A>T	uc001sys.2	+	8	1240	c.569A>T	c.(568-570)AAG>ATG	p.K190M	SYT1_uc001syt.2_Missense_Mutation_p.K190M|SYT1_uc001syu.2_Missense_Mutation_p.K187M|SYT1_uc001syv.2_Missense_Mutation_p.K190M	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	190	Cytoplasmic (Potential).|Phospholipid binding (Probable).|C2 1.				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						CTACCTGATAAGAAGAAGAAA	0.418000													20	42					0	0	0	0
PAWR	5074	broad.mit.edu	37	12	79988212	79988212	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:79988212T>A	uc001syx.2	-	6	1119	c.833A>T	c.(832-834)GAA>GTA	p.E278V		NM_002583	NP_002574	Q96IZ0	PAWR_HUMAN	PRKC, apoptosis, WT1, regulator	278					actin filament bundle assembly|apoptosis|induction of apoptosis|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	actin binding|enzyme binding|leucine zipper domain binding|transcription corepressor activity				0						TCTTACTACTTCCTGGTAGAT	0.294000													8	16					0	0	0	0
ACSS3	79611	broad.mit.edu	37	12	81503457	81503457	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:81503457T>A	uc001szl.1	+	2	521	c.430T>A	c.(430-432)TTT>ATT	p.F144I	ACSS3_uc001szm.1_Missense_Mutation_p.F143I	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	144						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						TAAAGCAACCTTTACCTATAA	0.299000													7	25					0	0	0	0
EEA1	8411	broad.mit.edu	37	12	93213152	93213152	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:93213152G>C	uc001tck.2	-	14	1925	c.1660C>G	c.(1660-1662)CAG>GAG	p.Q554E		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	554	Gln/Glu/Lys-rich.|Potential.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						TCACCAGCCTGAATTTTTGCA	0.313000													6	30					0	0	0	0
ANO4	121601	broad.mit.edu	37	12	101510564	101510564	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:101510564T>C	uc010svm.1	+	25	3130	c.2558T>C	c.(2557-2559)CTT>CCT	p.L853P	ANO4_uc001thw.2_Missense_Mutation_p.L818P|ANO4_uc001thx.2_Missense_Mutation_p.L853P|ANO4_uc001thy.2_Missense_Mutation_p.L373P	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	853	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						GGGACTCCTCTTAAGTACTGC	0.542000										HNSCC(74;0.22)			4	81					0	0	0	0
UTP20	27340	broad.mit.edu	37	12	101779782	101779782	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:101779782A>G	uc001tia.1	+	62	8395	c.8239A>G	c.(8239-8241)ATG>GTG	p.M2747V		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	2747	Nuclear localization signal.|Potential.|Nucleolar localization signal.				endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						CAAGAAAAAAATGAAGAAACA	0.308000													23	51					0	0	0	0
MYBPC1	4604	broad.mit.edu	37	12	102036248	102036248	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:102036248G>A	uc001tii.2	+	9	744	c.642G>A	c.(640-642)CTG>CTA	p.L214L	MYBPC1_uc001tif.1_Silent_p.L227L|MYBPC1_uc001tig.2_Silent_p.L239L|MYBPC1_uc010svq.1_Silent_p.L201L|MYBPC1_uc001tih.2_Silent_p.L239L|MYBPC1_uc001tij.2_Silent_p.L214L|MYBPC1_uc010svr.1_Silent_p.L214L|MYBPC1_uc010svs.1_Silent_p.L214L|MYBPC1_uc010svt.1_Silent_p.L202L|MYBPC1_uc010svu.1_Silent_p.L195L|MYBPC1_uc001tik.2_Silent_p.L188L	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	214					cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						GGGAGTTGCTGAAGAACGCGA	0.562000													15	43					0	0	0	0
ATP2A2	488	broad.mit.edu	37	12	110764234	110764234	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:110764234C>T	uc001tqk.3	+	7	1147	c.584C>T	c.(583-585)CCT>CTT	p.P195L	ATP2A2_uc001tql.3_Missense_Mutation_p.P195L|ATP2A2_uc010sxy.1_Missense_Mutation_p.P168L	NM_170665	NP_733765	P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, slow twitch 2 isoform	195	Cytoplasmic (By similarity).				ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			ovary(3)|skin(1)	4						GATCCCGTCCCTGACCCACGA	0.423000													4	25					0	0	0	0
SBNO1	55206	broad.mit.edu	37	12	123780467	123780467	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:123780467C>G	uc010tap.1	-	31	4170	c.4170G>C	c.(4168-4170)TTG>TTC	p.L1390F	SBNO1_uc009zxv.2_RNA|SBNO1_uc010tao.1_Missense_Mutation_p.L1389F|SBNO1_uc010taq.1_Missense_Mutation_p.L341F	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1390							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		ATGCGTTGCTCAAGTTGGTGA	0.428000													8	257					0	0	0	0
GJB2	2706	broad.mit.edu	37	13	20763385	20763385	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr13:20763385C>T	uc001umy.2	-	2	551	c.336G>A	c.(334-336)AAG>AAA	p.K112K		NM_004004	NP_003995	P29033	CXB2_HUMAN	gap junction protein beta 2	112	Cytoplasmic (Potential).			K -> N (in Ref. 4; AAY25170).	cell-cell signaling|cellular membrane organization|gap junction assembly|sensory perception of sound|transport	connexon complex|ER-Golgi intermediate compartment|integral to membrane					0		all_cancers(29;3.95e-22)|all_epithelial(30;2.36e-19)|all_lung(29;2.27e-18)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;0.000435)|Epithelial(112;0.000722)|OV - Ovarian serous cystadenocarcinoma(117;0.0096)|Lung(94;0.0236)|LUSC - Lung squamous cell carcinoma(192;0.0738)		TAAATTCACTCTTTATCTCCC	0.532000									Keratitis_Ichthyosis_and_Deafness_syndrome		OREG0022282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	57					0	0	0	0
FRY	10129	broad.mit.edu	37	13	32869543	32869543	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr13:32869543C>A	uc001utx.2	+	61	9484	c.8988C>A	c.(8986-8988)TAC>TAA	p.Y2996*	FRY_uc010tdw.1_RNA|FRY_uc001utz.2_Nonsense_Mutation_p.Y527*|FRY_uc010tdx.1_Nonsense_Mutation_p.Y366*	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2996					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CCCAGAGTTACCGAGTCCTCA	0.567000													20	46					1.2644e-06	2.33933e-06	1	0
BRCA2	675	broad.mit.edu	37	13	32950881	32950881	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr13:32950881G>A	uc001uub.1	+	21	8934	c.8707G>A	c.(8707-8709)GAG>AAG	p.E2903K		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2903					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AGATGGTGCAGAGCTTTATGA	0.388000			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			5	26					0	0	0	0
DIAPH3	81624	broad.mit.edu	37	13	60544172	60544172	+	Silent	SNP	A	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr13:60544172A>T	uc001vht.2	-	17	2199	c.1980T>A	c.(1978-1980)ACT>ACA	p.T660T	DIAPH3_uc001vhu.2_Silent_p.T397T|DIAPH3_uc001vhv.2_Silent_p.T238T	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	660	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		AACAGTTTTCAGTCATTTCAT	0.353000													7	7					0	0	0	0
TDRD3	81550	broad.mit.edu	37	13	61068665	61068665	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr13:61068665T>G	uc001via.2	+	8	1323	c.535T>G	c.(535-537)TCA>GCA	p.S179A	TDRD3_uc010aef.2_5'UTR|TDRD3_uc001vhz.3_Missense_Mutation_p.S179A|TDRD3_uc010aeg.2_Missense_Mutation_p.S272A|TDRD3_uc001vib.3_Missense_Mutation_p.S178A	NM_030794	NP_110421	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3 isoform 2	179					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			upper_aerodigestive_tract(1)|skin(1)	2		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		GAAAGAAAAGTCAACCAAATC	0.363000													6	36					0	0	0	0
DACH1	1602	broad.mit.edu	37	13	72063278	72063278	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr13:72063278C>T	uc010thn.1	-	8	1996	c.1573G>A	c.(1573-1575)GAG>AAG	p.E525K	DACH1_uc010tho.1_Missense_Mutation_p.E377K|DACH1_uc010thp.1_Missense_Mutation_p.E323K	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	577					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		AGCGGGGTCTCATCTGCATGT	0.428000													26	109					0	0	0	0
TBC1D4	9882	broad.mit.edu	37	13	75873593	75873593	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr13:75873593C>A	uc001vjl.1	-	17	3376	c.3029G>T	c.(3028-3030)GGG>GTG	p.G1010V	TBC1D4_uc010tht.1_Missense_Mutation_p.G220V|TBC1D4_uc010thu.1_Missense_Mutation_p.G167V|TBC1D4_uc010aer.2_Missense_Mutation_p.G1002V|TBC1D4_uc010aes.2_Missense_Mutation_p.G947V	NM_014832	NP_055647	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	1010	Rab-GAP TBC.					cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		AAAGCTGATCCCCTGACAGTA	0.493000													19	30					5.35356e-11	1.00204e-10	1	0
NALCN	259232	broad.mit.edu	37	13	101890129	101890129	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr13:101890129G>A	uc001vox.1	-	12	1600	c.1411C>T	c.(1411-1413)CAT>TAT	p.H471Y	NALCN_uc001voy.2_Missense_Mutation_p.H186Y|NALCN_uc001voz.2_Missense_Mutation_p.H471Y|NALCN_uc001vpa.2_Missense_Mutation_p.H471Y	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	471	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AATTGTGAATGATAAAGATCT	0.308000													39	130					0	0	0	0
TUBGCP3	10426	broad.mit.edu	37	13	113223541	113223541	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr13:113223541G>A	uc001vse.1	-	2	296	c.109C>T	c.(109-111)CGG>TGG	p.R37W	TUBGCP3_uc010tjq.1_Missense_Mutation_p.R37W|TUBGCP3_uc001vsf.2_Missense_Mutation_p.R37W|TUBGCP3_uc001vsg.1_Missense_Mutation_p.R37W	NM_006322	NP_006313	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	37					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					CCAATCACCCGCACAGCATAC	0.433000													15	42					0	0	0	0
OR4Q3	441669	broad.mit.edu	37	14	20216405	20216405	+	Silent	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:20216405C>A	uc010tkt.1	+	1	819	c.819C>A	c.(817-819)TCC>TCA	p.S273S		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	273	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGATATTCTCCTTGTTTTACA	0.433000													20	157					7.41877e-09	1.38054e-08	1	0
MYH7	4625	broad.mit.edu	37	14	23884302	23884302	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:23884302C>G	uc001wjx.2	-	37	5567	c.5461G>C	c.(5461-5463)GAG>CAG	p.E1821Q		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1821	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TTCTCCAGCTCCCGCACCCGC	0.627000													16	109					0	0	0	0
KIAA0391	9692	broad.mit.edu	37	14	35593231	35593231	+	Silent	SNP	A	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:35593231A>C	uc001wsy.1	+	2	1140	c.780A>C	c.(778-780)GTA>GTC	p.V260V	KIAA0391_uc010tps.1_Silent_p.V165V|KIAA0391_uc001wsz.1_Silent_p.V260V|KIAA0391_uc001wta.2_RNA|KIAA0391_uc001wtb.1_Silent_p.V260V|KIAA0391_uc001wtc.1_Intron|PPP2R3C_uc001wss.2_5'Flank|PPP2R3C_uc001wst.2_5'Flank|PPP2R3C_uc010tpr.1_5'Flank|PPP2R3C_uc001wsu.2_5'Flank|PPP2R3C_uc010amn.1_5'Flank|PPP2R3C_uc001wsw.2_5'Flank|PPP2R3C_uc001wsx.1_5'Flank	NM_014672	NP_055487	O15091	MRRP3_HUMAN	mitochondrial RNase P protein 3 precursor	260					tRNA processing	mitochondrion					0	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;2.93e-05)|LUAD - Lung adenocarcinoma(48;3.86e-05)|Epithelial(34;0.0114)|all cancers(34;0.0277)	GBM - Glioblastoma multiforme(112;0.0593)		ATCAAGATGTAAACACAGCTT	0.343000													9	20					0	0	0	0
MDGA2	161357	broad.mit.edu	37	14	47504427	47504427	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:47504427C>G	uc001wwj.3	-	8	1595	c.1399G>C	c.(1399-1401)GTA>CTA	p.V467L	MDGA2_uc001wwi.3_Missense_Mutation_p.V238L|MDGA2_uc010ani.2_Missense_Mutation_p.V27L	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	467	Ig-like 5.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						TTGCCAGTTACTTGACATTGC	0.413000													32	75					0	0	0	0
KCNH5	27133	broad.mit.edu	37	14	63175134	63175134	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:63175134C>T	uc001xfx.2	-	11	2110	c.2059G>A	c.(2059-2061)GAG>AAG	p.E687K	KCNH5_uc001xfy.2_3'UTR	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	687	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		AGGCGCTCCTCCTCCTCTTTC	0.493000													16	68					0	0	0	0
EXD2	55218	broad.mit.edu	37	14	69701456	69701456	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:69701456C>T	uc001xkt.2	+	7	1041	c.382C>T	c.(382-384)CTC>TTC	p.L128F	EXD2_uc001xku.2_Intron|EXD2_uc001xkv.2_Missense_Mutation_p.L253F|EXD2_uc001xkw.2_Missense_Mutation_p.L128F|EXD2_uc010aqt.2_Missense_Mutation_p.L253F|EXD2_uc010tte.1_Missense_Mutation_p.L253F|EXD2_uc001xky.2_Missense_Mutation_p.L128F	NM_018199	NP_060669	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2	128					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding				0						TTCAGTGGCTCTCTTTCTTCA	0.433000													9	26					0	0	0	0
C14orf169	79697	broad.mit.edu	37	14	73959074	73959074	+	Silent	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:73959074G>C	uc001xok.1	+	3	1432	c.1353G>C	c.(1351-1353)CGG>CGC	p.R451R	HEATR4_uc010tua.1_Intron	NM_024644	NP_078920	Q9H6W3	NO66_HUMAN	chromosome 14 open reading frame 169	451					negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K4 specific)|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.215)		TGGAGTTTCGGAGGGGTCTGC	0.547000													13	45					0	0	0	0
SEL1L	6400	broad.mit.edu	37	14	81972553	81972553	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:81972553C>T	uc010tvv.1	-	4	490	c.373G>A	c.(373-375)GAG>AAG	p.E125K	SEL1L_uc001xvo.3_Missense_Mutation_p.E125K	NM_005065	NP_005056	Q9UBV2	SE1L1_HUMAN	sel-1 suppressor of lin-12-like precursor	125	Lumenal (Potential).|Interaction with ERLEC1, OS9 and SYVN1.|Fibronectin type-II.				Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0299)		TGGCAGGGCTCCCCATGTGCT	0.438000													12	39					0	0	0	0
SLC24A4	123041	broad.mit.edu	37	14	92959967	92959967	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:92959967G>A	uc001yak.2	+	17	1837	c.1813G>A	c.(1813-1815)GAT>AAT	p.D605N	SLC24A4_uc001yai.2_Missense_Mutation_p.D558N|SLC24A4_uc010twm.1_Missense_Mutation_p.D603N|SLC24A4_uc001yaj.2_Missense_Mutation_p.D586N|SLC24A4_uc010auj.2_3'UTR|SLC24A4_uc010twn.1_Missense_Mutation_p.D378N|SLC24A4_uc001yan.2_Missense_Mutation_p.D316N	NM_153646	NP_705932	Q8NFF2	NCKX4_HUMAN	solute carrier family 24 member 4 isoform 1	622	Extracellular (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(2)|ovary(1)	3		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		CCGGGAAGACGATTAGCGCTG	0.547000													4	20					0	0	0	0
FAM181A	90050	broad.mit.edu	37	14	94395169	94395169	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:94395169G>A	uc001ybz.1	+	3	1031	c.724G>A	c.(724-726)GAG>AAG	p.E242K	C14orf86_uc001yby.2_5'Flank|FAM181A_uc010aus.1_Missense_Mutation_p.E180K|FAM181A_uc001yca.1_Missense_Mutation_p.E180K	NM_138344	NP_612353	Q8N9Y4	F181A_HUMAN	hypothetical protein LOC90050	242											0						CCTGGGACCTGAGACTACCCT	0.622000													4	33					0	0	0	0
DDX24	57062	broad.mit.edu	37	14	94521392	94521392	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:94521392C>T	uc001ycj.2	-	7	2227	c.2128G>A	c.(2128-2130)GAG>AAG	p.E710K	DDX24_uc010twq.1_Missense_Mutation_p.E667K|DDX24_uc010twr.1_Missense_Mutation_p.E460K	NM_020414	NP_065147	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	710	Helicase C-terminal.				RNA metabolic process	cytoplasm|nucleolus|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|skin(1)	4		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		GGGATATCCTCATCTTTCTTG	0.463000													32	149					0	0	0	0
IFI27L1	122509	broad.mit.edu	37	14	94567115	94567115	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:94567115G>C	uc001ycl.2	+	3	267	c.59G>C	c.(58-60)GGA>GCA	p.G20A	IFI27L1_uc001yck.2_Missense_Mutation_p.G20A	NM_206949	NP_996832	Q96BM0	I27L1_HUMAN	interferon, alpha-inducible protein 27-like 1	20	Helical; (Potential).					integral to membrane					0						GTGGTCGGAGGAGGTGAGTCT	0.507000													14	62					0	0	0	0
ATG2B	55102	broad.mit.edu	37	14	96757161	96757161	+	Silent	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:96757161T>C	uc001yfi.2	-	39	6056	c.5691A>G	c.(5689-5691)CTA>CTG	p.L1897L		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	1897										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		CTAATTGTACTAGTGAATGCA	0.284000													26	66					0	0	0	0
AKT1	207	broad.mit.edu	37	14	105246455	105246455	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:105246455C>T	uc001ypk.2	-	3	699	c.145G>A	c.(145-147)GAG>AAG	p.E49K	INF2_uc010tyi.1_Intron|AKT1_uc001ypl.2_Missense_Mutation_p.E49K|AKT1_uc010axa.2_Missense_Mutation_p.E49K|AKT1_uc001ypm.2_Missense_Mutation_p.E49K|AKT1_uc001ypn.2_Missense_Mutation_p.E49K|AKT1_uc010tyk.1_5'Flank	NM_005163	NP_005154	P31749	AKT1_HUMAN	AKT1 kinase	49	PH.				activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity	p.E49K(1)		breast(86)|urinary_tract(12)|thyroid(10)|lung(7)|endometrium(5)|large_intestine(4)|skin(4)|prostate(3)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|NS(1)	134		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)	AGGGGAGCCTCACGTTGGTCC	0.587000		1	Mis		breast|colorectal|ovarian|NSCLC								11	13					0	0	0	0
ATP10A	57194	broad.mit.edu	37	15	25963462	25963462	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr15:25963462C>A	uc010ayu.2	-	8	1554	c.1448G>T	c.(1447-1449)AGC>ATC	p.S483I		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	483	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GCTGCCGATGCTGCCGCGCTG	0.711000													11	8					6.40141e-05	0.000117086	1	0
MYO5A	4644	broad.mit.edu	37	15	52656782	52656782	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr15:52656782T>A	uc002aby.2	-	24	3522	c.3278A>T	c.(3277-3279)GAT>GTT	p.D1093V	MYO5A_uc002abx.3_Missense_Mutation_p.D1093V	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	1093	Potential.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		CTTGAGGTCATCATATCTTTC	0.284000													25	54					0	0	0	0
TLN2	83660	broad.mit.edu	37	15	63128147	63128147	+	Missense_Mutation	SNP	C	G	G	rs140723056	by1000genomes	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr15:63128147C>G	uc002alb.3	+	54	7249	c.7249C>G	c.(7249-7251)CAG>GAG	p.Q2417E	TLN2_uc002alc.3_Missense_Mutation_p.Q810E|TLN2_uc010uic.1_Missense_Mutation_p.Q18E|uc002ale.1_5'Flank	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	2417	I/LWEQ.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						TGCCTCCGTTCAGGGACACGC	0.647000													5	37					0	0	0	0
CALML4	91860	broad.mit.edu	37	15	68489825	68489825	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr15:68489825A>T	uc002arb.2	-	4	1180	c.446T>A	c.(445-447)CTG>CAG	p.L149Q	CALML4_uc002arc.2_Missense_Mutation_p.L102Q|CALML4_uc002ard.2_RNA|CALML4_uc002are.2_RNA|CALML4_uc010bhz.2_Intron	NM_033429	NP_219501	Q96GE6	CALL4_HUMAN	calmodulin-like 4 isoform 1	149	EF-hand 3.						calcium ion binding				0						TTTTGACCGCAGGTCGGACGC	0.498000													21	71					0	0	0	0
GOLGA6L5	374650	broad.mit.edu	37	15	85056021	85056021	+	RNA	SNP	T	C	C	rs1062001		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr15:85056021T>C	uc002bkm.2	-	6		c.539A>G				NR_003246				Homo sapiens cDNA FLJ33459 fis, clone BRAMY2000585.												0						GTAGCTGCTCTACCTTAGATG	0.502000													3	7					0	0	0	0
ERCC4	2072	broad.mit.edu	37	16	14020442	14020442	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr16:14020442G>A	uc002dce.2	+	3	422	c.413G>A	c.(412-414)AGA>AAA	p.R138K	ERCC4_uc010bva.2_Missense_Mutation_p.R138K	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	138					double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10						AGAGCCCACAGAATAATCGAG	0.353000			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				6	98					0	0	0	0
Unknown	0	broad.mit.edu	37	16	32077573	32077573	+	RNA	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr16:32077573C>T	uc010vfu.1	+	1		c.15C>T								Homo sapiens mRNA for immunoglobulin heavy chain, VHDJH rearrangement : VHLI26.																		TACGCAGACTCTGTGAAAGGC	0.517000													70	226					0	0	0	0
C16orf46	123775	broad.mit.edu	37	16	81087678	81087678	+	Nonstop_Mutation	SNP	A	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr16:81087678A>G	uc010chf.2	-	4	1335	c.1165T>C	c.(1165-1167)TAG>CAG	p.*389Q		NM_001100873	NP_001094343	Q6P387	CP046_HUMAN	chromosome 16 open reading frame 46 isoform 1	389											0						TCCCTCTCCTACTTTATCTTC	0.408000													16	38					0	0	0	0
MBTPS1	8720	broad.mit.edu	37	16	84108251	84108251	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr16:84108251T>A	uc002fhi.2	-	12	2046	c.1544A>T	c.(1543-1545)AAT>ATT	p.N515I	MBTPS1_uc002fhh.2_Missense_Mutation_p.N19I	NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	515	Lumenal (Potential).				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						GATGGTGACATTAACAACTGT	0.478000													16	27					0	0	0	0
JPH3	57338	broad.mit.edu	37	16	87678544	87678544	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr16:87678544C>T	uc002fkd.2	+	2	1317	c.1063C>T	c.(1063-1065)CGG>TGG	p.R355W	JPH3_uc010vou.1_RNA	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	355	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)		CATCCCCCTGCGGGCCAGCAA	0.652000													10	24					0	0	0	0
ZC3H18	124245	broad.mit.edu	37	16	88664701	88664701	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr16:88664701C>T	uc002fky.2	+	4	1004	c.804C>T	c.(802-804)CTC>CTT	p.L268L	ZC3H18_uc010voy.1_Silent_p.L151L|ZC3H18_uc010voz.1_Silent_p.L292L	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	268	Pro-rich.					nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		CCCCGCCTCTCGGACCTCACC	0.537000													6	62					0	0	0	0
RPA1	6117	broad.mit.edu	37	17	1783840	1783840	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:1783840G>A	uc002fto.2	+	12	1211	c.1096G>A	c.(1096-1098)GAT>AAT	p.D366N		NM_002945	NP_002936	P27694	RFA1_HUMAN	replication protein A1	366					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding				0						TTTACAGGCTGATAAATTTGA	0.428000								NER					16	33					0	0	0	0
NEURL4	84461	broad.mit.edu	37	17	7230539	7230539	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:7230539C>T	uc002gga.1	-	3	745	c.738G>A	c.(736-738)GTG>GTA	p.V246V	NEURL4_uc002ggb.1_Silent_p.V246V|NEURL4_uc002ggc.1_5'Flank	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	246							protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						GCGCTGGGGACACCATGAAGG	0.627000													8	16					0	0	0	0
POLR2A	5430	broad.mit.edu	37	17	7399540	7399540	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:7399540G>C	uc002ghf.3	+	3	472	c.238G>C	c.(238-240)GAG>CAG	p.E80Q	POLR2A_uc002ghe.2_Missense_Mutation_p.E80Q	NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	80					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				AAACATGACAGAGTGTCCTGG	0.537000													6	48					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578413	7578413	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:7578413C>A	uc002gim.2	-	5	711	c.517G>T	c.(517-519)GTG>TTG	p.V173L	TP53_uc002gig.1_Missense_Mutation_p.V173L|TP53_uc002gih.2_Missense_Mutation_p.V173L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V41L|TP53_uc010cng.1_Missense_Mutation_p.V41L|TP53_uc002gii.1_Missense_Mutation_p.V41L|TP53_uc010cnh.1_Missense_Mutation_p.V173L|TP53_uc010cni.1_Missense_Mutation_p.V173L|TP53_uc002gij.2_Missense_Mutation_p.V173L|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V80L|TP53_uc002gio.2_Missense_Mutation_p.V41L|TP53_uc010vug.1_Missense_Mutation_p.V134L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	173	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> M (in LFS; germline mutation and in sporadic cancers; somatic mutation).|V -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|V -> E (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> A (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V173L(54)|p.V173M(40)|p.V173A(8)|p.V173V(8)|p.0?(7)|p.V173G(6)|p.V173fs*1(4)|p.V80L(2)|p.V173fs*59(2)|p.V41L(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V172_R174delVVR(1)|p.V173fs*69(1)|p.P151_V173del23(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.V173E(1)|p.E171fs*1(1)|p.V173W(1)|p.V173fs*8(1)|p.H168fs*69(1)|p.V80M(1)|p.E171_H179delEVVRRCPHH(1)|p.S149fs*72(1)|p.V41M(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCGCCTCACAACCTCCGTC	0.662000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			31	22					9.65021e-13	1.84938e-12	1	0
DNAH2	146754	broad.mit.edu	37	17	7637808	7637808	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:7637808C>T	uc002giu.1	+	6	774	c.760C>T	c.(760-762)CGG>TGG	p.R254W	DNAH2_uc002git.2_Missense_Mutation_p.R254W|DNAH2_uc010vuk.1_Missense_Mutation_p.R254W	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	254	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CCACTGGACCCGGCAGATAAA	0.537000													9	38					0	0	0	0
KDM6B	23135	broad.mit.edu	37	17	7752018	7752018	+	Silent	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:7752018C>G	uc002giw.1	+	11	2788	c.2412C>G	c.(2410-2412)CTC>CTG	p.L804L	KDM6B_uc002gix.2_Silent_p.L106L	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	804	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CCAGCCTGCTCAAATCCTTGG	0.363000													6	52					0	0	0	0
CHD3	1107	broad.mit.edu	37	17	7794330	7794330	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:7794330G>A	uc002gje.2	+	4	607	c.457G>A	c.(457-459)GAG>AAG	p.E153K	CHD3_uc002gjd.2_Missense_Mutation_p.E212K|CHD3_uc002gjf.2_Missense_Mutation_p.E153K|CHD3_uc002gjg.1_5'UTR	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	153					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				TGTGTTCTCTGAGGAGGATTA	0.512000													28	70					0	0	0	0
MYH8	4626	broad.mit.edu	37	17	10309390	10309390	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:10309390C>G	uc002gmm.2	-	21	2495	c.2400G>C	c.(2398-2400)ATG>ATC	p.M800I	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	800	IQ.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						ATTCTACCCTCATTAGGAATC	0.373000									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				8	66					0	0	0	0
DNAH9	1770	broad.mit.edu	37	17	11607549	11607549	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:11607549G>A	uc002gne.2	+	25	5249	c.5181G>A	c.(5179-5181)TGG>TGA	p.W1727*	DNAH9_uc010coo.2_Nonsense_Mutation_p.W1021*	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1727	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGATCTGGTGGACAACAGAAG	0.507000													5	112					0	0	0	0
PRPSAP2	5636	broad.mit.edu	37	17	18775924	18775924	+	Silent	SNP	G	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:18775924G>T	uc002gup.1	+	5	412	c.201G>T	c.(199-201)GTG>GTT	p.V67V	PRPSAP2_uc002guo.1_5'UTR|PRPSAP2_uc010vyi.1_Intron|PRPSAP2_uc010vyj.1_5'UTR|PRPSAP2_uc010vyk.1_Silent_p.V55V	NM_002767	NP_002758	O60256	KPRB_HUMAN	phosphoribosyl pyrophosphate	67					nucleotide biosynthetic process		enzyme inhibitor activity|magnesium ion binding|ribose phosphate diphosphokinase activity			skin(1)	1						AAGAGTCTGTGAGGGGAAAAG	0.348000													41	168					1.57019e-19	3.06403e-19	1	0
KIAA0100	9703	broad.mit.edu	37	17	26965108	26965108	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:26965108C>G	uc002hbu.2	-	14	1616	c.1517G>C	c.(1516-1518)AGC>ACC	p.S506T		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	506						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					CTGGTTATAGCTACCCTAGAG	0.498000													12	54					0	0	0	0
KRT27	342574	broad.mit.edu	37	17	38938473	38938473	+	Silent	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:38938473G>C	uc002hvg.2	-	1	314	c.273C>G	c.(271-273)CTC>CTG	p.L91L		NM_181537	NP_853515	Q7Z3Y8	K1C27_HUMAN	keratin 27	91	Rod.|Coil 1A.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.000812)				AGCGGTCGTTGAGGTTCTGCA	0.572000													33	63					0	0	0	0
DHX8	1659	broad.mit.edu	37	17	41585799	41585799	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:41585799C>T	uc002idu.1	+	16	2486	c.2413C>T	c.(2413-2415)CCA>TCA	p.P805S	DHX8_uc010wif.1_Missense_Mutation_p.P714S|DHX8_uc010wig.1_Missense_Mutation_p.P805S	NM_004941	NP_004932	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	805	Helicase C-terminal.					catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		ACCTGATGTTCCAGAGTTAAT	0.488000													13	61					0	0	0	0
ARHGAP27	201176	broad.mit.edu	37	17	43480174	43480174	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:43480174G>A	uc002iix.2	-	9	1075	c.626C>T	c.(625-627)TCC>TTC	p.S209F	ARHGAP27_uc010dak.2_Missense_Mutation_p.S182F|ARHGAP27_uc010wjl.1_Missense_Mutation_p.S328F	NM_199282	NP_954976	Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27 isoform a	550	PH.				positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding				0	Renal(3;0.0405)					GGAAAACTTGGAAGGCTGCCT	0.572000													19	38					0	0	0	0
Unknown	0	broad.mit.edu	37	17	45128685	45128685	+	5'Flank	SNP	T	C	C	rs145089594	by1000genomes	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:45128685T>C	uc010wkl.1	-						uc010wkm.1_RNA					Homo sapiens cDNA FLJ38031 fis, clone CTONG2013348.																		TTCCAGGATATGGCTATACTG	0.289000													5	77					0	0	0	0
ABCA8	10351	broad.mit.edu	37	17	66890418	66890418	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:66890418T>C	uc002jhp.2	-	21	2991	c.2812A>G	c.(2812-2814)AGA>GGA	p.R938G	ABCA8_uc002jhq.2_Missense_Mutation_p.R978G|ABCA8_uc010wqq.1_Missense_Mutation_p.R978G|ABCA8_uc010wqr.1_Missense_Mutation_p.R917G|ABCA8_uc002jhr.2_Missense_Mutation_p.R978G	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	938						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					CAATTCAATCTTTTGGCATTG	0.313000													7	14					0	0	0	0
NOL4	8715	broad.mit.edu	37	18	31523045	31523045	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr18:31523045C>T	uc010dmi.2	-	9	1755	c.1526G>A	c.(1525-1527)CGT>CAT	p.R509H	NOL4_uc010xbs.1_Missense_Mutation_p.R224H|NOL4_uc002kxr.3_Missense_Mutation_p.R281H|NOL4_uc010xbt.1_Missense_Mutation_p.R435H|NOL4_uc010dmh.2_Missense_Mutation_p.R371H|NOL4_uc010xbu.1_Missense_Mutation_p.R445H|NOL4_uc002kxt.3_Intron|NOL4_uc010xbv.1_Missense_Mutation_p.R194H	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	509						nucleolus	RNA binding			ovary(3)	3						TCTCTCCAGACGCATCCTCTT	0.443000													10	56					0	0	0	0
DTNA	1837	broad.mit.edu	37	18	32428280	32428280	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr18:32428280G>A	uc010dmn.1	+	13	1287	c.1286G>A	c.(1285-1287)CGG>CAG	p.R429Q	DTNA_uc010xbx.1_Intron|DTNA_uc002kxv.3_Missense_Mutation_p.R372Q|DTNA_uc002kxw.2_Missense_Mutation_p.R372Q|DTNA_uc010dmj.2_Missense_Mutation_p.R369Q|DTNA_uc002kxz.2_Missense_Mutation_p.R369Q|DTNA_uc002kxy.2_Missense_Mutation_p.R369Q|DTNA_uc010dml.2_Missense_Mutation_p.R369Q|DTNA_uc002kyb.3_Missense_Mutation_p.R426Q|DTNA_uc010dmm.2_Missense_Mutation_p.R429Q|DTNA_uc010xby.1_Missense_Mutation_p.R119Q|DTNA_uc010dmo.2_Missense_Mutation_p.R51Q|DTNA_uc002kyd.3_Missense_Mutation_p.R51Q|DTNA_uc010xbz.1_Missense_Mutation_p.R138Q|DTNA_uc010xca.1_Missense_Mutation_p.R81Q|DTNA_uc002kye.2_Missense_Mutation_p.R77Q	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	429	Syntrophin-binding region.				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						AGTTCAAACCGGCTTGATGAA	0.448000													20	24					0	0	0	0
CDH19	28513	broad.mit.edu	37	18	64178908	64178908	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr18:64178908G>A	uc002lkc.1	-	10	1611	c.1473C>T	c.(1471-1473)ATC>ATT	p.I491I	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Intron	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	491	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				CCACTGCACTGATAGTCTGAA	0.318000													20	32					0	0	0	0
SHD	56961	broad.mit.edu	37	19	4282869	4282869	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:4282869G>A	uc002lzw.2	+	2	1763	c.300G>A	c.(298-300)CTG>CTA	p.L100L	SHD_uc010dtu.2_Silent_p.L100L	NM_020209	NP_064594	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming	100											0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCCGCAGCTGGAAGCCGACA	0.572000													32	54					0	0	0	0
CD320	51293	broad.mit.edu	37	19	8367860	8367860	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:8367860G>A	uc002mjj.1	-	4	572	c.507C>T	c.(505-507)ACC>ACT	p.T169T	CD320_uc002mjk.1_RNA|CD320_uc002mjl.1_Silent_p.T127T	NM_016579	NP_057663	Q9NPF0	CD320_HUMAN	8D6 antigen isoform 1 precursor	169	Extracellular (Potential).				regulation of cell growth	endoplasmic reticulum|integral to membrane	growth factor activity				0						GGATCTCATTGGTTCCTGCAA	0.607000													4	15					0	0	0	0
ZNF266	10781	broad.mit.edu	37	19	9524534	9524534	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:9524534T>G	uc002mll.2	-	4	1333	c.1067A>C	c.(1066-1068)GAT>GCT	p.D356A	ZNF266_uc002mlm.2_Missense_Mutation_p.D356A|ZNF266_uc002mln.2_Missense_Mutation_p.D356A|ZNF266_uc002mlo.2_Missense_Mutation_p.D356A|ZNF266_uc010dwp.2_Missense_Mutation_p.D356A|ZNF266_uc010dwq.2_Missense_Mutation_p.D356A	NM_198058	NP_932175	Q14584	ZN266_HUMAN	zinc finger protein 266	356	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTTCCCACAATCCTTACATTT	0.413000													18	46					0	0	0	0
ZNF442	79973	broad.mit.edu	37	19	12461237	12461237	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:12461237G>C	uc002mtr.1	-	6	1773	c.1162C>G	c.(1162-1164)CAT>GAT	p.H388D	ZNF442_uc010xmk.1_Missense_Mutation_p.H319D	NM_030824	NP_110451	Q9H7R0	ZN442_HUMAN	zinc finger protein 442	388	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|breast(1)|kidney(1)	4						CTTGAGTGATGAGATAACGCT	0.428000													9	168					0	0	0	0
MAST1	22983	broad.mit.edu	37	19	12969220	12969220	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:12969220C>T	uc002mvm.2	+	11	1250	c.1122C>T	c.(1120-1122)TTC>TTT	p.F374F	MAST1_uc002mvk.2_Silent_p.F370F	NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	374	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						AGAATGACTTCGATACCATCA	0.582000													21	131					0	0	0	0
ZNF708	7562	broad.mit.edu	37	19	21492100	21492100	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:21492100T>A	uc002npq.1	-	3	372	c.174A>T	c.(172-174)CAA>CAT	p.Q58H	ZNF708_uc002npr.1_Translation_Start_Site|ZNF708_uc010ecs.1_Translation_Start_Site	NM_021269	NP_067092	P17019	ZN708_HUMAN	zinc finger protein 708	58	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(4)|skin(2)	6						GCTCTTTTCCTTGCTCCAGAC	0.428000													24	72					0	0	0	0
ZNF493	284443	broad.mit.edu	37	19	21606747	21606747	+	Missense_Mutation	SNP	G	C	C	rs143136118		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:21606747G>C	uc002npx.2	+	2	1182	c.902G>C	c.(901-903)GGA>GCA	p.G301A	ZNF493_uc002npw.2_Missense_Mutation_p.G429A|ZNF493_uc002npy.2_Missense_Mutation_p.G301A	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	301					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATTCATACTGGAGAGAAACCC	0.338000													3	30					0	0	0	0
ZNF91	7644	broad.mit.edu	37	19	23542840	23542840	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:23542840G>A	uc002nre.2	-	4	3054	c.2941C>T	c.(2941-2943)CTT>TTT	p.L981F	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Missense_Mutation_p.L949F	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	981	C2H2-type 30.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TGTTCAGTAAGAGTTGAAGAT	0.378000													5	48					0	0	0	0
KIRREL2	84063	broad.mit.edu	37	19	36355599	36355599	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:36355599G>A	uc002ocb.3	+	14	1987	c.1775G>A	c.(1774-1776)GGG>GAG	p.G592E	KIRREL2_uc002obz.3_Missense_Mutation_p.G592E|KIRREL2_uc002oca.3_Missense_Mutation_p.G542E|KIRREL2_uc002occ.3_Missense_Mutation_p.G539E|KIRREL2_uc002ocd.3_Missense_Mutation_p.G554E	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	592	Cytoplasmic (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GAGGAGAAAGGGACTCTGGAG	0.597000													26	16					0	0	0	0
PSG5	5673	broad.mit.edu	37	19	43688992	43688992	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:43688992G>C	uc002ovu.2	-	2	503	c.372C>G	c.(370-372)ATC>ATG	p.I124M	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Missense_Mutation_p.I52M|PSG5_uc002ovx.2_Missense_Mutation_p.I124M|PSG5_uc002ovv.2_Missense_Mutation_p.I124M|PSG5_uc002ovw.2_Missense_Mutation_p.I124M	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	124	Ig-like V-type.				female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				CTCGCTTTATGATGTGTAAGG	0.493000													114	238					0	0	0	0
ZNF233	353355	broad.mit.edu	37	19	44777511	44777511	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:44777511C>A	uc002oyz.1	+	5	825	c.698C>A	c.(697-699)GCT>GAT	p.A233D	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Missense_Mutation_p.A48D	NM_181756	NP_861421	A6NK53	ZN233_HUMAN	zinc finger protein 233	233					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)				AGAGAGAAAGCTTTTAGCCAC	0.368000													9	26					0.000274275	0.000498823	1	0
SFRS16	11129	broad.mit.edu	37	19	45563652	45563652	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:45563652T>A	uc002pak.2	+	9	814	c.716T>A	c.(715-717)CTC>CAC	p.L239H	SFRS16_uc002pal.2_RNA|SFRS16_uc010xxh.1_Missense_Mutation_p.L177H|SFRS16_uc002pam.2_Missense_Mutation_p.L239H|SFRS16_uc002pan.1_RNA	NM_007056	NP_008987	Q8N2M8	CLASR_HUMAN	splicing factor, arginine/serine-rich 16	239					mRNA processing|RNA splicing	nucleus					0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TATAGGATGCTCCGGAAAGAC	0.572000													8	28					0	0	0	0
SYMPK	8189	broad.mit.edu	37	19	46328447	46328447	+	Silent	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:46328447C>G	uc002pdn.2	-	18	2717	c.2472G>C	c.(2470-2472)CTG>CTC	p.L824L	SYMPK_uc002pdo.1_Silent_p.L824L|SYMPK_uc002pdp.1_Silent_p.L824L	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	824					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		CAATGACCCTCAGCACCGTCC	0.647000													5	66					0	0	0	0
GRLF1	2909	broad.mit.edu	37	19	47503732	47503732	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:47503732C>G	uc010ekv.2	+	6	4287	c.4287C>G	c.(4285-4287)ATC>ATG	p.I1429M		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	1429	Rho-GAP.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		AACTCTTTATCCAGCAGTGCC	0.597000													30	103					0	0	0	0
NUP62	23636	broad.mit.edu	37	19	50412910	50412910	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:50412910G>C	uc002pqx.2	-	2	259	c.155C>G	c.(154-156)ACA>AGA	p.T52R	IL4I1_uc002pqv.1_Intron|IL4I1_uc010eno.1_Intron|IL4I1_uc002pqw.1_Intron|IL4I1_uc002pqu.1_Intron|NUP62_uc002pqy.2_Missense_Mutation_p.T52R|NUP62_uc002pqz.2_Missense_Mutation_p.T52R|NUP62_uc002pra.2_Missense_Mutation_p.T52R|NUP62_uc002prb.2_Missense_Mutation_p.T52R|NUP62_uc002prc.2_Missense_Mutation_p.T52R	NM_153719	NP_714941	P37198	NUP62_HUMAN	nucleoporin 62kDa	52	15 X 9 AA approximate repeats.|Thr-rich.				carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding				0		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		AGGGGTACTTGTGGCTGGTTG	0.567000													7	134					0	0	0	0
SIGLEC5	8778	broad.mit.edu	37	19	52115506	52115506	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:52115506G>A	uc002pxe.2	-	9	1773	c.1634C>T	c.(1633-1635)TCG>TTG	p.S545L		NM_003830	NP_003821	O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5 precursor	545	SLAM-like motif.|Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding			skin(2)|breast(1)|central_nervous_system(1)	4		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		CTTGATCTCCGAGTACTCCGT	0.537000													16	80					0	0	0	0
APOB	338	broad.mit.edu	37	2	21224885	21224885	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:21224885G>A	uc002red.2	-	29	13537	c.13409C>T	c.(13408-13410)TCT>TTT	p.S4470F		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4470					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AGCAGTGGCAGAAAGCTCTGC	0.383000													12	71					0	0	0	0
PFN4	375189	broad.mit.edu	37	2	24345335	24345335	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:24345335A>T	uc002rfa.1	-	2	247	c.71T>A	c.(70-72)ATC>AAC	p.I24N	LOC375190_uc002rew.2_Intron|LOC375190_uc010ykl.1_5'Flank|LOC375190_uc002rfb.2_5'Flank	NM_199346	NP_955378	Q8NHR9	PROF4_HUMAN	profilin family, member 4	24					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGGATTTTGATGAGGGCTGC	0.428000													65	49					0	0	0	0
DNMT3A	1788	broad.mit.edu	37	2	25463307	25463307	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:25463307C>T	uc002rgc.2	-	19	2443	c.2186G>A	c.(2185-2187)CGG>CAG	p.R729Q	DNMT3A_uc002rgd.2_Missense_Mutation_p.R729Q|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Missense_Mutation_p.R540Q	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	729					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding	p.R729Q(1)|p.R729W(1)		haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAAGAAGAGCCGGCCAGTGCC	0.612000			Mis|F|N|S		AML								30	28					0	0	0	0
EHBP1	23301	broad.mit.edu	37	2	63217961	63217961	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:63217961G>A	uc002sby.2	+	18	3414	c.2932G>A	c.(2932-2934)GAG>AAG	p.E978K	EHBP1_uc010fcp.2_Missense_Mutation_p.E907K|EHBP1_uc002sbz.2_Missense_Mutation_p.E907K|EHBP1_uc002scb.2_Missense_Mutation_p.E943K	NM_015252	NP_056067	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1 isoform 1	978						cytoplasm|membrane				ovary(1)|breast(1)	2	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			TGAGAGCTCAGAGCAGGACAT	0.418000									Hereditary_Prostate_Cancer				6	38					0	0	0	0
MEIS1	4211	broad.mit.edu	37	2	66775128	66775128	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:66775128C>T	uc002sdu.2	+	9	1399	c.942C>T	c.(940-942)CTC>CTT	p.L314L	MEIS1_uc002sdt.2_Silent_p.L314L|MEIS1_uc002sdv.2_Silent_p.L312L|MEIS1_uc010yqh.1_RNA|MEIS1_uc010yqi.1_Silent_p.L249L|MEIS1_uc002sdw.1_Silent_p.L170L	NM_002398	NP_002389	O00470	MEIS1_HUMAN	Meis homeobox 1	314	Homeobox; TALE-type.						sequence-specific DNA binding transcription factor activity				0						ACACGGGACTCACCATCCTTC	0.423000													13	31					0	0	0	0
ASPRV1	151516	broad.mit.edu	37	2	70188034	70188034	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:70188034G>A	uc002sfz.3	-	1	1364	c.787C>T	c.(787-789)CTA>TTA	p.L263L		NM_152792	NP_690005	Q53RT3	APRV1_HUMAN	aspartic peptidase, retroviral-like 1 precursor	263	Peptidase A2.|Extracellular (Potential).				protein maturation by peptide bond cleavage|skin development		aspartic-type endopeptidase activity			ovary(1)	1						AGCTTGCCTAGGGACACCGCT	0.542000													25	60					0	0	0	0
ZNF638	27332	broad.mit.edu	37	2	71653623	71653623	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:71653623G>T	uc002shx.2	+	24	4943	c.4624G>T	c.(4624-4626)GTT>TTT	p.V1542F	ZNF638_uc002shy.2_Missense_Mutation_p.V1542F|ZNF638_uc002shz.2_Missense_Mutation_p.V1542F|ZNF638_uc002sia.2_Missense_Mutation_p.V1542F|ZNF638_uc002sib.1_Missense_Mutation_p.L1133F|ZNF638_uc010fed.2_Intron|ZNF638_uc002sic.2_Missense_Mutation_p.V639F|ZNF638_uc002sid.2_5'UTR	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	1542					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						GGATGAATTTGTTACTGTGGA	0.348000													18	20					1.56452e-12	2.98049e-12	1	0
REG1B	5968	broad.mit.edu	37	2	79314023	79314023	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:79314023C>G	uc002sny.2	-	3	210	c.98G>C	c.(97-99)CGA>CCA	p.R33P	REG1B_uc010ffv.1_Missense_Mutation_p.R33P|REG1B_uc010ffw.2_Missense_Mutation_p.R33P	NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor	33					cell proliferation	extracellular region	sugar binding	p.R33*(1)		central_nervous_system(1)|skin(1)	2						GCAGCTGATTCGGGGATTAGG	0.498000													68	53					0	0	0	0
CTNNA2	1496	broad.mit.edu	37	2	79878701	79878701	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:79878701C>T	uc010ysh.1	+	1	24	c.19C>T	c.(19-21)CCT>TCT	p.P7S	CTNNA2_uc010yse.1_Missense_Mutation_p.P7S|CTNNA2_uc010ysf.1_Missense_Mutation_p.P7S|CTNNA2_uc010ysg.1_Missense_Mutation_p.P7S|hsa-mir-4264|MI0015877_5'Flank	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	7					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GGCAACTTCACCTATCATTCT	0.403000													24	57					0	0	0	0
DPP10	57628	broad.mit.edu	37	2	116447315	116447315	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:116447315G>A	uc002tla.1	+	6	951	c.494G>A	c.(493-495)AGG>AAG	p.R165K	DPP10_uc002tlb.1_Missense_Mutation_p.R115K|DPP10_uc002tlc.1_Missense_Mutation_p.R161K|DPP10_uc002tle.2_Missense_Mutation_p.R169K|DPP10_uc002tlf.1_Missense_Mutation_p.R158K	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	165	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						ATACACACTAGGTAAGTTCTT	0.264000													4	16					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141260622	141260622	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:141260622G>C	uc002tvj.1	-	54	9544	c.8572C>G	c.(8572-8574)CTT>GTT	p.L2858V		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2858	Extracellular (Potential).|LDL-receptor class A 19.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTATTTAGAAGACACCGCCCA	0.388000										TSP Lung(27;0.18)			20	52					0	0	0	0
MBD5	55777	broad.mit.edu	37	2	149227843	149227843	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:149227843C>T	uc002twm.3	+	9	3319	c.2331C>T	c.(2329-2331)AAC>AAT	p.N777N	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Silent_p.N777N|MBD5_uc002twn.1_Silent_p.N218N	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	777						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		CAGTCCCCAACCACCATCTTG	0.463000													21	63					0	0	0	0
NEB	4703	broad.mit.edu	37	2	152499769	152499769	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:152499769C>G	uc010fnx.2	-	58	8246	c.8055G>C	c.(8053-8055)TTG>TTC	p.L2685F		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2685	Nebulin 72.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CATGGTCACTCAAAATCTGGG	0.413000													3	109					0	0	0	0
XIRP2	129446	broad.mit.edu	37	2	168102261	168102261	+	Silent	SNP	T	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:168102261T>G	uc002udx.2	+	8	4377	c.4359T>G	c.(4357-4359)ACT>ACG	p.T1453T	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.T1278T|XIRP2_uc010fpq.2_Silent_p.T1231T|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1278	Xin 26.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AAACATCTACTTGGCTATTTG	0.348000													10	15					0	0	0	0
GPR155	151556	broad.mit.edu	37	2	175346518	175346518	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:175346518C>G	uc002uit.2	-	3	558	c.167G>C	c.(166-168)GGC>GCC	p.G56A	GPR155_uc002uiu.2_Missense_Mutation_p.G56A|GPR155_uc002uiv.2_Missense_Mutation_p.G56A|GPR155_uc010fqs.2_Missense_Mutation_p.G56A	NM_001033045	NP_001028217	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155 isoform 9	56	Helical; (Potential).				intracellular signal transduction|transmembrane transport	integral to membrane				ovary(1)	1						TGCTATGTAGCCACAAAGGAC	0.418000													12	34					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179395647	179395647	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:179395647G>T	uc010zfg.1	-	307	98215	c.97991C>A	c.(97990-97992)CCA>CAA	p.P32664Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P26359Q|TTN_uc010zfi.1_Missense_Mutation_p.P26292Q|TTN_uc010zfj.1_Missense_Mutation_p.P26167Q|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33591							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGACTCTTGGTGGTGATGT	0.478000													13	141					4.36969e-10	8.15506e-10	1	0
TTN	7273	broad.mit.edu	37	2	179593094	179593094	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:179593094T>G	uc010zfg.1	-	64	15949	c.15725A>C	c.(15724-15726)AAA>ACA	p.K5242T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.K1903T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6169							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGGTTAATTTTTTGGTGAA	0.358000													6	13					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179654776	179654776	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:179654776G>T	uc010zfg.1	-	12	2091	c.1867C>A	c.(1867-1869)CAA>AAA	p.Q623K	TTN_uc010zfh.1_Missense_Mutation_p.Q577K|TTN_uc010zfi.1_Missense_Mutation_p.Q577K|TTN_uc010zfj.1_Missense_Mutation_p.Q577K|TTN_uc002unb.2_Missense_Mutation_p.Q623K|TTN_uc010frg.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	623							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTAAATCTTGTTCTTTGACT	0.348000													18	27					3.51602e-12	6.67835e-12	1	0
TTN	7273	broad.mit.edu	37	2	179655440	179655440	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:179655440C>T	uc010zfg.1	-	11	2019	c.1795G>A	c.(1795-1797)GAA>AAA	p.E599K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002unb.2_Missense_Mutation_p.E599K|TTN_uc010frg.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	599							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCACCTTTTCATAACTTAGG	0.408000													6	82					0	0	0	0
PMS1	5378	broad.mit.edu	37	2	190719576	190719576	+	Silent	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:190719576T>C	uc002urh.3	+	9	2107	c.1578T>C	c.(1576-1578)TGT>TGC	p.C526C	PMS1_uc010zga.1_Silent_p.C487C|PMS1_uc010zgb.1_Silent_p.C465C|PMS1_uc002urk.3_Silent_p.C487C|PMS1_uc002uri.3_Silent_p.C526C|PMS1_uc010zgc.1_Silent_p.C350C|PMS1_uc010zgd.1_Silent_p.C350C|PMS1_uc002urj.2_RNA|PMS1_uc010fry.1_Silent_p.C487C|PMS1_uc010frz.2_Intron|PMS1_uc002url.2_Silent_p.C311C|PMS1_uc002urm.2_RNA|PMS1_uc002urn.1_Silent_p.C194C	NM_000534	NP_000525	P54277	PMS1_HUMAN	postmeiotic segregation 1 isoform a	526					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			GTTTACCATGTAAAGTAAGTA	0.294000			Mis|N			colorectal|endometrial|ovarian		Direct_reversal_of_damage|MMR					12	30					0	0	0	0
STAT1	6772	broad.mit.edu	37	2	191863005	191863005	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:191863005C>T	uc002usj.2	-	8	959	c.571G>A	c.(571-573)GAT>AAT	p.D191N	STAT1_uc010fse.1_Missense_Mutation_p.D191N|STAT1_uc002usk.2_Missense_Mutation_p.D191N|STAT1_uc002usl.2_Missense_Mutation_p.D193N|STAT1_uc010fsf.1_Intron	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	191					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	TGTTTCTGATCACTCTTTGCC	0.338000													7	64					0	0	0	0
DNAH7	56171	broad.mit.edu	37	2	196664153	196664153	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:196664153C>T	uc002utj.3	-	55	10321	c.10220G>A	c.(10219-10221)CGT>CAT	p.R3407H		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3407	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AATGAATGCACGTCCCAATCT	0.418000													28	75					0	0	0	0
GTF3C3	9330	broad.mit.edu	37	2	197641315	197641315	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:197641315C>T	uc002uts.2	-	11	1519	c.1429G>A	c.(1429-1431)GAA>AAA	p.E477K	GTF3C3_uc010zgu.1_Missense_Mutation_p.E448K	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	477	TPR 8.					transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7						CCATAGCTTTCAGCAGCTCGC	0.438000													5	87					0	0	0	0
FN1	2335	broad.mit.edu	37	2	216286886	216286886	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:216286886G>C	uc002vfa.2	-	10	1740	c.1474C>G	c.(1474-1476)CAC>GAC	p.H492D	FN1_uc002vfb.2_Missense_Mutation_p.H492D|FN1_uc002vfc.2_Missense_Mutation_p.H492D|FN1_uc002vfd.2_Missense_Mutation_p.H492D|FN1_uc002vfe.2_Missense_Mutation_p.H492D|FN1_uc002vff.2_Missense_Mutation_p.H492D|FN1_uc002vfg.2_Missense_Mutation_p.H492D|FN1_uc002vfh.2_Missense_Mutation_p.H492D|FN1_uc002vfi.2_Missense_Mutation_p.H492D|FN1_uc002vfj.2_Missense_Mutation_p.H492D|FN1_uc002vfl.2_Missense_Mutation_p.H492D	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	492	Collagen-binding.|Fibronectin type-I 7.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTCATCATGTGACCCATGTCA	0.478000													21	100					0	0	0	0
SP140	11262	broad.mit.edu	37	2	231112644	231112644	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:231112644C>T	uc002vql.2	+	8	871	c.756C>T	c.(754-756)AAC>AAT	p.N252N	SP140_uc010zma.1_Intron|SP140_uc002vqk.2_Silent_p.N252N|SP140_uc002vqn.2_Intron|SP140_uc002vqm.2_Silent_p.N226N|SP140_uc010fxl.2_Silent_p.N252N	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	252					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TAGAAAGCAACGGGATGATAG	0.443000													32	70					0	0	0	0
GBX2	2637	broad.mit.edu	37	2	237075004	237075004	+	Silent	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:237075004C>A	uc002vvw.1	-	2	638	c.600G>T	c.(598-600)TCG>TCT	p.S200S	GBX2_uc010zng.1_Missense_Mutation_p.A203S	NM_001485	NP_001476	P52951	GBX2_HUMAN	gastrulation brain homeo box 2	200						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Breast(86;0.00235)|Renal(207;0.00339)|all_hematologic(139;0.00357)|all_lung(227;0.0616)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|Lung NSC(271;0.179)		Epithelial(121;4.5e-25)|OV - Ovarian serous cystadenocarcinoma(60;5.16e-11)|BRCA - Breast invasive adenocarcinoma(100;3.4e-05)|Lung(119;0.00195)|LUSC - Lung squamous cell carcinoma(224;0.00471)		CGCTCTCCAGCGAGAAGCTCT	0.602000													39	79					2.75727e-19	5.34794e-19	1	0
TGM6	343641	broad.mit.edu	37	20	2375175	2375175	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr20:2375175G>A	uc002wfy.1	+	2	146	c.85G>A	c.(85-87)GAG>AAG	p.E29K	TGM6_uc010gal.1_Missense_Mutation_p.E29K	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	29					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	CCCCTGCCCTGAGCTGGTGGT	0.627000													4	30					0	0	0	0
TM9SF4	9777	broad.mit.edu	37	20	30729430	30729430	+	Silent	SNP	C	T	T	rs117023270	by1000genomes	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr20:30729430C>T	uc002wxj.2	+	4	595	c.360C>T	c.(358-360)CTC>CTT	p.L120L	TM9SF4_uc010ztr.1_Silent_p.L46L|TM9SF4_uc010zts.1_Silent_p.L27L|TM9SF4_uc002wxk.2_Silent_p.L103L|TM9SF4_uc010gdz.2_Silent_p.L27L	NM_014742	NP_055557	Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	120						integral to membrane				central_nervous_system(1)|pancreas(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AGAGCCGACTCGTGGCCGAGC	0.577000													9	137					0	0	0	0
NCOA6	23054	broad.mit.edu	37	20	33329653	33329653	+	Silent	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr20:33329653T>C	uc002xav.2	-	12	6978	c.4407A>G	c.(4405-4407)AAA>AAG	p.K1469K	NCOA6_uc002xaw.2_Silent_p.K1469K	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1469					brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						CACTGGGAAGTTTGTTAGGAT	0.448000													31	140					0	0	0	0
KIAA1755	85449	broad.mit.edu	37	20	36850870	36850870	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr20:36850870C>G	uc002xhy.1	-	10	2670	c.2398G>C	c.(2398-2400)GAC>CAC	p.D800H	KIAA1755_uc002xhx.1_Missense_Mutation_p.D78H	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	800										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				GGGCTGAAGTCCAGCCTGCTG	0.642000											OREG0025921	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	95					0	0	0	0
PLCG1	5335	broad.mit.edu	37	20	39791883	39791883	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr20:39791883G>C	uc002xjp.1	+	8	878	c.757G>C	c.(757-759)GAG>CAG	p.E253Q	PLCG1_uc002xjo.1_Missense_Mutation_p.E253Q|PLCG1_uc010zwe.1_5'Flank|PLCG1_uc010ggf.2_5'Flank	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	253					activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				GTCCCTTCCTGAGTTCCAGCA	0.607000													20	111					0	0	0	0
SLCO4A1	28231	broad.mit.edu	37	20	61292481	61292481	+	Missense_Mutation	SNP	G	A	A	rs138628669		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr20:61292481G>A	uc002ydb.1	+	5	1280	c.1075G>A	c.(1075-1077)GAG>AAG	p.E359K	SLCO4A1_uc002ydc.1_RNA	NM_016354	NP_057438	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family	359	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(1)	1	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			CAGCCGTGGGGAGGCGAGCAA	0.617000													30	67					0	0	0	0
DIDO1	11083	broad.mit.edu	37	20	61541176	61541176	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr20:61541176C>G	uc002ydr.1	-	4	1300	c.1036G>C	c.(1036-1038)GAT>CAT	p.D346H	DIDO1_uc002yds.1_Missense_Mutation_p.D346H|DIDO1_uc002ydt.1_Missense_Mutation_p.D346H|DIDO1_uc002ydu.1_Missense_Mutation_p.D346H|DIDO1_uc002ydv.1_Missense_Mutation_p.D346H|DIDO1_uc002ydw.1_Missense_Mutation_p.D346H|DIDO1_uc002ydx.1_Missense_Mutation_p.D346H|DIDO1_uc011aao.1_Missense_Mutation_p.D346H	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	346					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					TCGGTGCCATCAGCATCTCCA	0.458000													7	170					0	0	0	0
SAMD10	140700	broad.mit.edu	37	20	62608706	62608706	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr20:62608706C>T	uc002yhm.2	-	2	320	c.145G>A	c.(145-147)GAG>AAG	p.E49K	SAMD10_uc002yhn.2_RNA	NM_080621	NP_542188	Q9BYL1	SAM10_HUMAN	sterile alpha motif domain containing 10	49											0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					GGGATGCTCTCAGCTGACACC	0.652000													9	92					0	0	0	0
GABPA	2551	broad.mit.edu	37	21	27130510	27130510	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr21:27130510G>A	uc002ylx.3	+	6	1270	c.743G>A	c.(742-744)CGA>CAA	p.R248Q	GABPA_uc002yly.3_Missense_Mutation_p.R248Q	NM_002040	NP_002031	Q06546	GABPA_HUMAN	GA binding protein transcription factor, alpha	248	PNT.				positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)|central_nervous_system(1)	2						GAACTTCTCCGAAAATGTATG	0.328000													13	28					0	0	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28338237	28338237	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr21:28338237G>A	uc002ymg.2	-	1	1203	c.474C>T	c.(472-474)GTC>GTT	p.V158V		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	158					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						GCGCGTGCTTGACCGCGAAGA	0.657000													7	26					0	0	0	0
WRB	7485	broad.mit.edu	37	21	40762689	40762689	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr21:40762689G>A	uc002yxs.2	+	2	266	c.168G>A	c.(166-168)ATG>ATA	p.M56I	WRB_uc011aeo.1_RNA|WRB_uc011aep.1_Missense_Mutation_p.M56I|WRB_uc002yxt.3_Missense_Mutation_p.M22I|WRB_uc010goj.2_RNA	NM_004627	NP_004618	O00258	WRB_HUMAN	tryptophan rich basic protein isoform 1	56	Potential.					integral to membrane|nucleolus					0		Prostate(19;1.2e-06)				TCCAGGACATGAAGCAGGAGC	0.542000													4	28					0	0	0	0
SLC19A1	6573	broad.mit.edu	37	21	46951984	46951984	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr21:46951984G>A	uc002zhl.1	-	3	387	c.268C>T	c.(268-270)CTG>TTG	p.L90L	SLC19A1_uc010gpy.1_Silent_p.L90L|SLC19A1_uc011aft.1_Silent_p.L50L|SLC19A1_uc002zhm.1_Silent_p.L90L|SLC19A1_uc010gpz.1_5'UTR	NM_194255	NP_919231	P41440	S19A1_HUMAN	solute carrier family 19 member 1	90	Cytoplasmic (Probable).				folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity				0				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		GTGTAGCGCAGGTAGTCGGTG	0.672000													16	28					0	0	0	0
psiTPTE22	387590	broad.mit.edu	37	22	17119533	17119533	+	RNA	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:17119533G>A	uc002zls.1	+	2		c.370G>A			psiTPTE22_uc002zlr.2_RNA|psiTPTE22_uc002zlt.2_RNA					Homo sapiens cDNA FLJ10437 fis, clone NT2RP1000581.												0						AATTTTCACTGACAGCAAACT	0.323000													17	58					0	0	0	0
DGCR2	9993	broad.mit.edu	37	22	19076905	19076905	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:19076905C>T	uc002zoq.1	-	2	426	c.178G>A	c.(178-180)GAG>AAG	p.E60K	DGCR2_uc002zor.1_5'UTR|DGCR2_uc011agr.1_Intron	NM_005137	NP_005128	P98153	IDD_HUMAN	integral membrane protein DGCR2 precursor	60	Extracellular (Potential).|LDL-receptor class A.				cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			large_intestine(1)	1	Colorectal(54;0.0993)					TCGTCGCTCTCATCCTCGCAA	0.607000													14	123					0	0	0	0
CLTCL1	8218	broad.mit.edu	37	22	19183840	19183840	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:19183840G>A	uc002zpb.2	-	27	4203	c.4128C>T	c.(4126-4128)CTC>CTT	p.L1376L	CLTCL1_uc011agv.1_Silent_p.L1376L|CLTCL1_uc011agw.1_Silent_p.L1355L|CLTCL1_uc011agt.1_Silent_p.L167L|CLTCL1_uc011agu.1_Silent_p.L167L|CLTCL1_uc010grm.1_Silent_p.L136L|CLTCL1_uc002zpe.2_3'UTR|CLTCL1_uc002zpd.1_Silent_p.L283L	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	1376	Involved in binding clathrin light chain (By similarity).|Proximal segment.|Heavy chain arm.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					TCATCATGGTGAGCACAGCAT	0.567000			T	?	ALCL								8	72					0	0	0	0
CLTCL1	8218	broad.mit.edu	37	22	19209480	19209480	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:19209480C>G	uc002zpb.2	-	16	2630	c.2555G>C	c.(2554-2556)AGA>ACA	p.R852T	CLTCL1_uc011agv.1_Missense_Mutation_p.R852T|CLTCL1_uc011agw.1_Missense_Mutation_p.R852T	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	852	Proximal segment.|Heavy chain arm.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					TTACCTATTTCTTTTTTCTAC	0.418000			T	?	ALCL								7	106					0	0	0	0
TBX1	6899	broad.mit.edu	37	22	19766783	19766783	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:19766783G>A	uc002zqb.2	+	9	1179	c.1050G>A	c.(1048-1050)ACG>ACA	p.T350T	TBX1_uc002zqc.2_Intron	NM_080646	NP_542377	O43435	TBX1_HUMAN	T-box 1 isoform A	350					embryonic viscerocranium morphogenesis|heart development|parathyroid gland development|pharyngeal system development|regulation of transcription from RNA polymerase II promoter|soft palate development|thymus development	nucleus	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|breast(1)	2	Colorectal(54;0.0993)	all_lung(157;3.05e-06)				AAGCTGAGACGTCTAGGAACA	0.547000													23	137					0	0	0	0
PI4KA	5297	broad.mit.edu	37	22	21157491	21157491	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:21157491G>A	uc002zsz.3	-	13	1636	c.1405C>T	c.(1405-1407)CAG>TAG	p.Q469*	PI4KA_uc010gsq.1_Nonsense_Mutation_p.Q527*	NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	469					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			GTGTGGTACTGACTGTGGTAC	0.547000													14	158					0	0	0	0
P2RX6	9127	broad.mit.edu	37	22	21377467	21377467	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:21377467C>T	uc010gsu.1	+	6	618	c.618C>T	c.(616-618)TTC>TTT	p.F206F	P2RX6_uc002ztz.2_Silent_p.F180F|P2RX6_uc002zua.2_RNA|P2RX6_uc002zuc.1_RNA	NM_005446	NP_005437	O15547	P2RX6_HUMAN	purinergic receptor P2X6 isoform 1	206	Extracellular (Potential).				muscle contraction|protein homooligomerization	cell junction|cytoplasm|integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0						CAGTCACCTTCAGCAAGTTCA	0.572000													11	283					0	0	0	0
MYO18B	84700	broad.mit.edu	37	22	26343755	26343755	+	Silent	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:26343755G>C	uc003abz.1	+	36	5959	c.5709G>C	c.(5707-5709)CTG>CTC	p.L1903L	MYO18B_uc003aca.1_Silent_p.L1784L|MYO18B_uc010guy.1_Silent_p.L1785L|MYO18B_uc010guz.1_Silent_p.L1783L|MYO18B_uc011aka.1_Silent_p.L1057L|MYO18B_uc011akb.1_Silent_p.L1416L	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1903	Tail.|Potential.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						AGGATGACCTGAATGAGCTGA	0.557000													9	18					0	0	0	0
CRYBA4	1413	broad.mit.edu	37	22	27026341	27026341	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:27026341C>T	uc003acz.3	+	6	516	c.481C>T	c.(481-483)CAG>TAG	p.Q161*		NM_001886	NP_001877	P53673	CRBA4_HUMAN	crystallin, beta A4	161	Beta/gamma crystallin 'Greek key' 4.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens				0						CCGAGGATTTCAGTATGTGCT	0.537000													12	35					0	0	0	0
TCN2	6948	broad.mit.edu	37	22	31010483	31010483	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:31010483C>T	uc003aip.1	+	4	733	c.575C>T	c.(574-576)TCT>TTT	p.S192F	TCN2_uc003aiq.1_Missense_Mutation_p.S188F|TCN2_uc003air.1_Missense_Mutation_p.S165F	NM_000355	NP_000346	P20062	TCO2_HUMAN	transcobalamin II precursor	192	Cobalamin binding.				cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular space	cobalamin binding			central_nervous_system(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GGCCACCATTCTGTGGGTGAG	0.602000													9	17					0	0	0	0
FOXRED2	80020	broad.mit.edu	37	22	36886209	36886209	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:36886209T>C	uc003apn.3	-	8	2009	c.1901A>G	c.(1900-1902)CAC>CGC	p.H634R	FOXRED2_uc003apm.3_Missense_Mutation_p.H186R|FOXRED2_uc003apo.3_Missense_Mutation_p.H634R|FOXRED2_uc003app.3_Missense_Mutation_p.H634R	NM_024955	NP_079231	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	634					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			lung(1)|kidney(1)	2						CTCCACTCTGTGCTGCCAAAG	0.637000													12	100					0	0	0	0
MKL1	57591	broad.mit.edu	37	22	40825650	40825650	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:40825650G>T	uc003ayv.1	-	4	468	c.261C>A	c.(259-261)AAC>AAA	p.N87K	MKL1_uc003ayw.1_Missense_Mutation_p.N87K|MKL1_uc010gye.1_Missense_Mutation_p.N87K|MKL1_uc010gyf.1_Missense_Mutation_p.N87K	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	87	RPEL 2.|Mediates interaction with SCAI and ACTB (By similarity).				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						CAGGAAGGATGTTCTTCTCCA	0.577000			T	RBM15	acute megakaryocytic leukemia								35	14					1.99505e-19	3.88128e-19	1	0
PLXNB2	23654	broad.mit.edu	37	22	50721260	50721260	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:50721260C>T	uc003bkv.3	-	18	2973	c.2867G>A	c.(2866-2868)CGG>CAG	p.R956Q	PLXNB2_uc003bkt.1_5'Flank|PLXNB2_uc003bku.1_5'Flank	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	956	Extracellular (Potential).|IPT/TIG 2.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CATCTGGCCCCGTGTCGCCTG	0.672000													4	28					0	0	0	0
LRRN1	57633	broad.mit.edu	37	3	3888390	3888390	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:3888390G>T	uc003bpt.3	+	2	2826	c.2065G>T	c.(2065-2067)GAA>TAA	p.E689*	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	689	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TAACCTCTGGGAAGGTGACAG	0.413000													19	9					2.35188e-11	4.42788e-11	1	0
HACL1	26061	broad.mit.edu	37	3	15609959	15609959	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:15609959C>T	uc003caf.2	-	13	1390	c.1230G>A	c.(1228-1230)CAG>CAA	p.Q410Q	HACL1_uc011avr.1_RNA|HACL1_uc011avs.1_Silent_p.Q383Q|HACL1_uc011avt.1_Silent_p.Q350Q|HACL1_uc003cag.2_Silent_p.Q54Q|HACL1_uc011avu.1_Silent_p.Q328Q|HACL1_uc010hep.2_Silent_p.Q169Q	NM_012260	NP_036392	Q9UJ83	HACL1_HUMAN	2-hydroxyphytanoyl-CoA lyase	410	Thiamine pyrophosphate binding.				fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding				0						GAAGGTAGTTCTGAAGCACAG	0.368000													5	40					0	0	0	0
TGFBR2	7048	broad.mit.edu	37	3	30713698	30713698	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:30713698C>T	uc003ceo.2	+	4	1405	c.1023C>T	c.(1021-1023)GTC>GTT	p.V341V	TGFBR2_uc003cen.2_Silent_p.V366V	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	341	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						CGCGGCATGTCATCAGCTGGG	0.617000													52	40					0	0	0	0
MLH1	4292	broad.mit.edu	37	3	37048548	37048548	+	Silent	SNP	G	A	A	rs63750638		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:37048548G>A	uc003cgl.2	+	5	507	c.447G>A	c.(445-447)CAG>CAA	p.Q149Q	MLH1_uc011aye.1_5'UTR|MLH1_uc011ayb.1_5'UTR|MLH1_uc010hge.2_Silent_p.Q149Q|MLH1_uc003cgn.3_5'UTR|MLH1_uc011ayc.1_Silent_p.Q51Q|MLH1_uc011ayd.1_5'UTR|MLH1_uc003cgo.2_5'UTR	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	149					mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						AAGGGACCCAGATCACGGTAA	0.343000		1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				22	15					0	0	0	0
DLEC1	9940	broad.mit.edu	37	3	38081086	38081086	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:38081086G>A	uc003cho.1	+	1	391	c.370G>A	c.(370-372)GAG>AAG	p.E124K	DLEC1_uc003chp.1_Missense_Mutation_p.E124K|DLEC1_uc010hgv.1_Missense_Mutation_p.E124K	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	124					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CCGCGGCAGCGAGAATGAGCG	0.647000													23	39					0	0	0	0
TTC21A	199223	broad.mit.edu	37	3	39156090	39156090	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:39156090G>A	uc003cjc.2	+	6	750	c.573G>A	c.(571-573)ATG>ATA	p.M191I	TTC21A_uc003cja.2_Missense_Mutation_p.M191I|TTC21A_uc010hho.1_Missense_Mutation_p.M113I|TTC21A_uc003cjb.2_Missense_Mutation_p.D58N|TTC21A_uc003cje.2_Missense_Mutation_p.M191I|TTC21A_uc003cjd.2_RNA|TTC21A_uc011ayx.1_Missense_Mutation_p.M150I	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	191	TPR 4.						binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TGTACTTCATGATGCAGCAGA	0.557000													62	57					0	0	0	0
ALS2CL	259173	broad.mit.edu	37	3	46713495	46713495	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:46713495C>G	uc003cqa.1	-	24	2753	c.2563G>C	c.(2563-2565)GAG>CAG	p.E855Q	ALS2CL_uc003cpx.1_Missense_Mutation_p.E202Q|ALS2CL_uc003cpy.1_RNA|ALS2CL_uc003cpz.1_Missense_Mutation_p.E370Q|ALS2CL_uc003cqb.1_Missense_Mutation_p.E855Q|ALS2CL_uc003cqc.1_RNA	NM_147129	NP_667340	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like isoform 1	855	VPS9.				endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		TCCAGCACCTCCAGCTTCTCC	0.622000													3	50					0	0	0	0
NBEAL2	23218	broad.mit.edu	37	3	47033992	47033992	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:47033992G>A	uc003cqp.2	+	10	1239	c.1060G>A	c.(1060-1062)GAG>AAG	p.E354K	NBEAL2_uc003cqq.1_Intron|NBEAL2_uc010hjm.1_5'Flank	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	354							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		GGCGCCCCCCGAGGGGGACAG	0.637000													5	4					0	0	0	0
CCDC36	339834	broad.mit.edu	37	3	49294689	49294689	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:49294689G>C	uc003cwk.2	+	10	2146	c.1759G>C	c.(1759-1761)GAT>CAT	p.D587H	CCDC36_uc011bck.1_Missense_Mutation_p.D587H	NM_178173	NP_835467	Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	587										ovary(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		CCTGGGTTTTGATAGCAGTGA	0.478000													3	162					0	0	0	0
RBM5	10181	broad.mit.edu	37	3	50151488	50151488	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:50151488G>C	uc003cyg.2	+	19	1871	c.1723G>C	c.(1723-1725)GAA>CAA	p.E575Q	RBM5_uc011bdj.1_Missense_Mutation_p.E519Q|RBM5_uc011bdk.1_Missense_Mutation_p.E403Q|RBM5_uc003cyh.2_Missense_Mutation_p.E32Q	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5	575	Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGAAAGGAGAGAATCTGCTGC	0.423000													22	24					0	0	0	0
GRM2	2912	broad.mit.edu	37	3	51749374	51749374	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:51749374G>C	uc010hlv.2	+	4	1824	c.1585G>C	c.(1585-1587)GAG>CAG	p.E529Q	GRM2_uc003dbo.3_5'UTR|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	529	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	CCAGCCCTATGAGTACCGATT	0.612000													6	15					0	0	0	0
SFMBT1	51460	broad.mit.edu	37	3	52947576	52947576	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:52947576G>C	uc003dgf.2	-	16	2107	c.1538C>G	c.(1537-1539)TCA>TGA	p.S513*	SFMBT1_uc010hmr.2_Nonsense_Mutation_p.S460*|SFMBT1_uc003dgg.2_Nonsense_Mutation_p.S513*|SFMBT1_uc003dgh.2_Nonsense_Mutation_p.S513*	NM_001005159	NP_001005159	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	513					regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		ATATGGCCCTGAGAAGCAACG	0.403000													13	11					0	0	0	0
ERC2	26059	broad.mit.edu	37	3	55984515	55984515	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:55984515G>A	uc003dhr.1	-	13	2597	c.2341C>T	c.(2341-2343)CAG>TAG	p.Q781*	ERC2_uc003dhq.1_RNA|ERC2_uc003dht.1_Nonsense_Mutation_p.Q260*	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	781	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TCTAGTAACTGAGCATTTTTC	0.428000													10	35					0	0	0	0
COL8A1	1295	broad.mit.edu	37	3	99513335	99513335	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:99513335G>A	uc003dtg.1	+	5	835	c.590G>A	c.(589-591)GGA>GAA	p.G197E	COL8A1_uc003dth.1_Missense_Mutation_p.G197E|COL8A1_uc003dti.1_Missense_Mutation_p.G198E	NM_001850	NP_001841	P27658	CO8A1_HUMAN	alpha 1 type VIII collagen precursor	197	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII					0						GGACCACAAGGACCTCCAGGG	0.587000													5	58					0	0	0	0
BOC	91653	broad.mit.edu	37	3	112998239	112998239	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:112998239A>T	uc003dzx.2	+	12	2578	c.1957A>T	c.(1957-1959)ATT>TTT	p.I653F	BOC_uc003dzy.2_Missense_Mutation_p.I653F|BOC_uc003dzz.2_Missense_Mutation_p.I654F|BOC_uc003eab.2_Missense_Mutation_p.I354F|BOC_uc003eac.2_5'Flank	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	653	Fibronectin type-III 2.|Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			GGGAGACTGGATTCTGGCCAC	0.602000													9	47					0	0	0	0
CD80	941	broad.mit.edu	37	3	119248769	119248769	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:119248769A>T	uc003ecq.2	-	5	1111	c.716T>A	c.(715-717)TTT>TAT	p.F239Y	CD80_uc010hqt.1_Intron|CD80_uc010hqu.1_Intron	NM_005191	NP_005182	P33681	CD80_HUMAN	CD80 antigen precursor	239	Extracellular (Potential).				interspecies interaction between organisms|intracellular signal transduction|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of signal transduction|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation	intracellular	coreceptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2					Abatacept(DB01281)	GTTATCAGGAAAATGCTCTTG	0.408000													5	61					0	0	0	0
NDUFB4	4710	broad.mit.edu	37	3	120315376	120315376	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:120315376G>A	uc003edu.2	+	1	249	c.170G>A	c.(169-171)CGA>CAA	p.R57Q	NDUFB4_uc003edt.2_Missense_Mutation_p.R57Q	NM_004547	NP_004538	O95168	NDUB4_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	57					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0				GBM - Glioblastoma multiforme(114;0.14)	NADH(DB00157)	CCCAACCGCCGAGGGCTCATC	0.632000													4	17					0	0	0	0
GOLGB1	2804	broad.mit.edu	37	3	121414936	121414936	+	Silent	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:121414936T>C	uc003eei.3	-	13	4545	c.4419A>G	c.(4417-4419)GAA>GAG	p.E1473E	GOLGB1_uc010hrc.2_Silent_p.E1478E|GOLGB1_uc003eej.3_Silent_p.E1439E|GOLGB1_uc011bjm.1_Silent_p.E1359E|GOLGB1_uc010hrd.1_Silent_p.E1437E	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1473	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		CTCTACTTTCTTCTCCAATCT	0.393000													42	223					0	0	0	0
TMEM22	80723	broad.mit.edu	37	3	136573801	136573801	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:136573801C>T	uc003erf.3	+	2	713	c.499C>T	c.(499-501)CGA>TGA	p.R167*	TMEM22_uc003erg.3_Nonsense_Mutation_p.R167*|TMEM22_uc010hub.2_Nonsense_Mutation_p.R167*	NM_001097600	NP_001091069	Q8TBE7	TMM22_HUMAN	transmembrane protein 22	167	DUF6 1.					Golgi apparatus|integral to membrane				ovary(1)	1						ATACAGATTACGACTCTTCTT	0.408000													34	160					0	0	0	0
AGTR1	185	broad.mit.edu	37	3	148459339	148459339	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:148459339G>A	uc003ewg.2	+	4	963	c.517G>A	c.(517-519)GAG>AAG	p.E173K	AGTR1_uc003ewh.2_Missense_Mutation_p.E173K|AGTR1_uc003ewi.2_Missense_Mutation_p.E173K|AGTR1_uc003ewj.2_Missense_Mutation_p.E173K|AGTR1_uc003ewk.2_Missense_Mutation_p.E173K	NM_031850	NP_114038	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	173	Extracellular (Potential).				calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity				0			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	ATTTTTCATTGAGAACACCAA	0.443000													25	85					0	0	0	0
VEPH1	79674	broad.mit.edu	37	3	157146114	157146114	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:157146114G>A	uc003fbj.1	-	5	1010	c.693C>T	c.(691-693)CTC>CTT	p.L231L	VEPH1_uc003fbk.1_Silent_p.L231L|VEPH1_uc010hvu.1_Silent_p.L231L	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	231						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			TTTTTACCTCGAGTTGTTTTT	0.438000													6	69					0	0	0	0
IFT80	57560	broad.mit.edu	37	3	160099354	160099354	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:160099354G>A	uc011boy.1	-	3	629	c.196C>T	c.(196-198)CCA>TCA	p.P66S	IFT80_uc003fda.2_Intron|IFT80_uc003fdb.1_5'UTR|IFT80_uc003fdd.1_5'UTR|IFT80_uc003fde.1_5'UTR	NM_020800	NP_065851	Q9P2H3	IFT80_HUMAN	WD repeat domain 56	66						cilium axoneme|microtubule basal body				ovary(1)	1			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AAACTTTTTGGAAACCAGTGA	0.358000													9	51					0	0	0	0
ABCC5	10057	broad.mit.edu	37	3	183707045	183707045	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:183707045T>C	uc003fmg.2	-	3	421	c.256A>G	c.(256-258)AGT>GGT	p.S86G	ABCC5_uc011bqt.1_5'UTR|ABCC5_uc010hxl.2_Missense_Mutation_p.S86G|ABCC5_uc003fmh.2_Missense_Mutation_p.S86G|ABCC5_uc010hxm.2_RNA|ABCC5_uc010hxn.2_Missense_Mutation_p.S86G|ABCC5_uc010hxo.2_Missense_Mutation_p.S86G	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	86						integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TTCAGAGCACTCAAGCCATGA	0.473000													28	17					0	0	0	0
BOD1L	259282	broad.mit.edu	37	4	13603813	13603813	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:13603813T>A	uc003gmz.1	-	10	4828	c.4711A>T	c.(4711-4713)AAT>TAT	p.N1571Y	BOD1L_uc010idr.1_Missense_Mutation_p.N908Y	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1571							DNA binding			ovary(5)|breast(1)	6						AGAGGATTATTTCTGGAATGT	0.468000													5	19					0	0	0	0
GPR125	166647	broad.mit.edu	37	4	22517230	22517230	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:22517230C>T	uc003gqm.1	-	1	443	c.178G>A	c.(178-180)GAG>AAG	p.E60K	GPR125_uc003gqo.2_Missense_Mutation_p.E60K	NM_145290	NP_660333	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125 precursor	60	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)				ACCTTGCCCTCGGCGGCGCCC	0.572000													11	11					0	0	0	0
PDS5A	23244	broad.mit.edu	37	4	39843630	39843630	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:39843630C>G	uc003guv.3	-	31	4135	c.3595G>C	c.(3595-3597)GAG>CAG	p.E1199Q	PDS5A_uc010ifo.2_Missense_Mutation_p.E1159Q	NM_001100399	NP_001093869	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog	1199					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding				0						ACAGGGTTCTCTTCATTTTCA	0.343000													4	41					0	0	0	0
DCAF4L1	285429	broad.mit.edu	37	4	41984115	41984115	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:41984115C>T	uc003gwk.2	+	1	403	c.306C>T	c.(304-306)ATC>ATT	p.I102I		NM_001029955	NP_001025126	Q3SXM0	DC4L1_HUMAN	WD repeat domain 21B	102										skin(1)	1						ACGGCATCATCAGCCTGCGAA	0.557000													17	42					0	0	0	0
SHISA3	152573	broad.mit.edu	37	4	42403210	42403210	+	Silent	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:42403210C>G	uc003gwp.2	+	2	677	c.459C>G	c.(457-459)ACC>ACG	p.T153T		NM_001080505	NP_001073974	A0PJX4	SHSA3_HUMAN	shisa homolog 3 precursor	153	Cytoplasmic (Potential).				multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				ovary(1)|skin(1)	2						TGACCTCCACCAGCCCCAGGG	0.647000													30	108					0	0	0	0
CHIC2	26511	broad.mit.edu	37	4	54880271	54880271	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:54880271C>T	uc003haj.1	-	4	667	c.346G>A	c.(346-348)GAG>AAG	p.E116K	PDGFRA_uc003haa.2_Intron	NM_012110	NP_036242	Q9UKJ5	CHIC2_HUMAN	cysteine-rich hydrophobic domain 2	116						plasma membrane	protein binding			central_nervous_system(1)	1	all_cancers(7;0.0193)|all_neural(26;0.0209)|Lung NSC(11;0.0281)|Glioma(25;0.08)		LUSC - Lung squamous cell carcinoma(32;0.00216)			AATAACTTCTCAATCGATCTT	0.403000			T	ETV6	AML								10	19					0	0	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68925156	68925156	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:68925156C>G	uc003hdt.1	-	9	1095	c.1046G>C	c.(1045-1047)AGA>ACA	p.R349T	LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	349	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						GGTTTCCACTCTGGCTTGCCG	0.358000													12	21					0	0	0	0
NDST4	64579	broad.mit.edu	37	4	115769459	115769459	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:115769459G>C	uc003ibu.2	-	9	2531	c.1852C>G	c.(1852-1854)CCT>GCT	p.P618A	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	618	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		ATGATTGAAGGATGCATAAGA	0.308000													4	60					0	0	0	0
QRFPR	84109	broad.mit.edu	37	4	122250496	122250496	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:122250496C>A	uc010inj.1	-	6	1648	c.1269G>T	c.(1267-1269)GAG>GAT	p.E423D	QRFPR_uc010ink.1_RNA|QRFPR_uc003ids.2_3'UTR	NM_198179	NP_937822	Q96P65	QRFPR_HUMAN	G protein-coupled receptor 103	423	Cytoplasmic (Potential).					plasma membrane	neuropeptide Y receptor activity				0						AAGGAGAATTCTCAGCCAGTT	0.368000													23	55					1.10513e-12	2.11159e-12	1	0
HPGD	3248	broad.mit.edu	37	4	175414436	175414436	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:175414436C>T	uc003itu.2	-	6	718	c.528G>A	c.(526-528)GTG>GTA	p.V176V	HPGD_uc003itt.2_Silent_p.V43V|HPGD_uc003itv.2_Intron|HPGD_uc011ckf.1_Silent_p.V55V|HPGD_uc010irp.2_Silent_p.V55V|HPGD_uc010irq.2_Intron|HPGD_uc011ckg.1_Silent_p.V108V|HPGD_uc011ckh.1_Silent_p.V55V	NM_000860	NP_000851	P15428	PGDH_HUMAN	hydroxyprostaglandin dehydrogenase 15-(NAD)	176					female pregnancy|lipoxygenase pathway|negative regulation of cell cycle|parturition|prostaglandin metabolic process|transforming growth factor beta receptor signaling pathway	cytosol|nucleus	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|NAD+ binding|prostaglandin E receptor activity|protein homodimerization activity				0		Prostate(90;0.00763)|Melanoma(52;0.0179)|Renal(120;0.0376)|Breast(14;0.0991)|all_hematologic(60;0.124)|all_neural(102;0.196)		all cancers(43;2.6e-18)|Epithelial(43;4.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.23e-09)|GBM - Glioblastoma multiforme(59;0.00176)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.0253)	NADH(DB00157)	CATTCAGTCTCACACCACTGT	0.363000													9	45					0	0	0	0
ADAM29	11086	broad.mit.edu	37	4	175897135	175897135	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:175897135C>T	uc003iuc.2	+	5	1129	c.459C>T	c.(457-459)GAC>GAT	p.D153D	ADAM29_uc003iud.2_Silent_p.D153D|ADAM29_uc010irr.2_Silent_p.D153D|ADAM29_uc011cki.1_Silent_p.D153D	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	153					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		ACAAGATGGACAGTGAGGAGA	0.363000													19	67					0	0	0	0
SNX25	83891	broad.mit.edu	37	4	186231908	186231908	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:186231908C>A	uc003ixh.2	+	7	979	c.790C>A	c.(790-792)CCT>ACT	p.P264T	SNX25_uc010ish.2_Missense_Mutation_p.P35T	NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	264					cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		CCTGGGAGGCCCTGCCTATGA	0.512000													14	80					4.14922e-12	7.85781e-12	1	0
ANKRD37	353322	broad.mit.edu	37	4	186318369	186318369	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:186318369G>A	uc003ixm.2	+	2	331	c.93G>A	c.(91-93)AAG>AAA	p.K31K	LRP2BP_uc011ckr.1_5'Flank|ANKRD37_uc011cks.1_Silent_p.K31K	NM_181726	NP_859077	Q7Z713	ANR37_HUMAN	ankyrin repeat domain 37	31	ANK 2.					cytoplasm|nucleus					0		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;1.27e-25)|Epithelial(43;1.02e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.14e-11)|BRCA - Breast invasive adenocarcinoma(30;7.72e-05)|GBM - Glioblastoma multiforme(59;0.000118)|STAD - Stomach adenocarcinoma(60;0.000756)|LUSC - Lung squamous cell carcinoma(40;0.00902)|COAD - Colon adenocarcinoma(29;0.00939)|READ - Rectum adenocarcinoma(43;0.155)		ATCCCTGCAAGCAGTCGCCTG	0.592000													14	73					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187630110	187630110	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:187630110G>C	uc003izf.2	-	2	1060	c.872C>G	c.(871-873)TCT>TGT	p.S291C	FAT1_uc010iso.1_Missense_Mutation_p.S291C	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	291	Extracellular (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GATGCTTAAAGATGCTATGTC	0.488000										HNSCC(5;0.00058)			20	173					0	0	0	0
DNAH5	1767	broad.mit.edu	37	5	13901432	13901432	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:13901432G>A	uc003jfd.2	-	14	2023	c.1981C>T	c.(1981-1983)CGC>TGC	p.R661C		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	661	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTGTAACTGCGAATTATAGGT	0.532000									Kartagener_syndrome				16	30					0	0	0	0
CDH9	1007	broad.mit.edu	37	5	26881405	26881405	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:26881405G>A	uc003jgs.1	-	12	2379	c.2210C>T	c.(2209-2211)ACG>ATG	p.T737M	CDH9_uc011cnv.1_Missense_Mutation_p.T330M	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	737	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						ATAGGCATACGTTGCCAGCGA	0.423000													29	72					0	0	0	0
PRLR	5618	broad.mit.edu	37	5	35086419	35086419	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:35086419C>G	uc003jjm.2	-	4	624	c.94G>C	c.(94-96)GAG>CAG	p.E32Q	PRLR_uc003jjg.1_Missense_Mutation_p.E32Q|PRLR_uc003jjh.1_Missense_Mutation_p.E32Q|PRLR_uc003jji.1_Intron|PRLR_uc003jjj.1_Missense_Mutation_p.E32Q|PRLR_uc003jjk.1_Intron|PRLR_uc003jjl.3_Intron|PRLR_uc010iuw.1_5'UTR	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	32	Fibronectin type-III 1.|Extracellular (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TTAAAGATCTCAGGTTTTCCA	0.448000													16	55					0	0	0	0
PAIP1	10605	broad.mit.edu	37	5	43539127	43539127	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:43539127C>T	uc003job.2	-	5	992	c.745G>A	c.(745-747)GAA>AAA	p.E249K	PAIP1_uc003joa.2_Missense_Mutation_p.E170K|PAIP1_uc010ivp.2_Missense_Mutation_p.E170K|PAIP1_uc010ivo.2_Intron|PAIP1_uc003joc.2_Missense_Mutation_p.E137K	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	249	MIF4G.				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					ACTTCATATTCAGTCCGACAT	0.333000													21	54					0	0	0	0
SNX18	112574	broad.mit.edu	37	5	53814496	53814496	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:53814496C>T	uc003jpj.3	+	1	904	c.714C>T	c.(712-714)TCC>TCT	p.S238S	SNX18_uc011cqg.1_Silent_p.S238S|SNX18_uc003jpi.3_Silent_p.S238S	NM_052870	NP_443102	Q96RF0	SNX18_HUMAN	sorting nexin 18 isoform b	238					cell communication|endocytosis|positive regulation of GTPase activity|protein transport	endomembrane system|endosome membrane|extrinsic to internal side of plasma membrane	phosphatidylinositol binding|protein binding				0		Lung NSC(810;3.46e-05)|Breast(144;0.102)				TCGTCAAGTCCGGCGGGGAGG	0.706000													20	45					0	0	0	0
LOC441089	441089	broad.mit.edu	37	5	79647313	79647313	+	RNA	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:79647313G>A	uc010jaj.1	-	1		c.473C>T				NR_003665				Homo sapiens CRSP8 pseudogene (LOC441089), non-coding RNA.												0						GGTAGGACAAGAGTTGTGGGC	0.463000													5	46					0	0	0	0
ANKRD34B	340120	broad.mit.edu	37	5	79854712	79854712	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:79854712G>C	uc010jam.2	-	4	1477	c.1127C>G	c.(1126-1128)TCA>TGA	p.S376*	ANKRD34B_uc003kgw.2_Nonsense_Mutation_p.S376*|ANKRD34B_uc010jan.2_Nonsense_Mutation_p.S376*	NM_001004441	NP_001004441	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	376						cytoplasm|nucleus				pancreas(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		AAGGCCAGCTGAGAGCTGGGA	0.438000													6	39					0	0	0	0
TTC37	9652	broad.mit.edu	37	5	94842673	94842673	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:94842673G>A	uc003klb.2	-	30	3327	c.3057C>T	c.(3055-3057)TAC>TAT	p.Y1019Y		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	1019							binding			ovary(3)|pancreas(1)	4						TTGCAACATTGTAAGTATCTT	0.323000													15	32					0	0	0	0
LNPEP	4012	broad.mit.edu	37	5	96320825	96320825	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:96320825C>G	uc003kmv.1	+	3	1416	c.902C>G	c.(901-903)TCT>TGT	p.S301C	LNPEP_uc003kmw.1_Missense_Mutation_p.S287C	NM_005575	NP_005566	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase isoform 1	301	Extracellular (Potential).			S -> L (in Ref. 6; AA sequence).	cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		GCAGCAAGATCTGCTTTTCCT	0.303000													22	87					0	0	0	0
NRG2	9542	broad.mit.edu	37	5	139231379	139231379	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:139231379T>A	uc003lex.1	-	9	1807	c.1582A>T	c.(1582-1584)AGC>TGC	p.S528C	NRG2_uc003lev.1_Missense_Mutation_p.S536C|NRG2_uc003lew.1_Missense_Mutation_p.S530C|NRG2_uc003ley.1_Missense_Mutation_p.S522C	NM_004883	NP_004874	O14511	NRG2_HUMAN	neuregulin 2 isoform 1	528	Cytoplasmic (Potential).				embryo development	extracellular region|integral to membrane|plasma membrane	growth factor activity			pancreas(2)|breast(2)|ovary(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAGTCAGGCTCTCAGAACGT	0.632000													7	32					0	0	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203557	140203557	+	Missense_Mutation	SNP	C	T	T	rs140039635		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:140203557C>T	uc003lhl.2	+	1	2197	c.2197C>T	c.(2197-2199)CGG>TGG	p.R733W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.R733W|PCDHA5_uc003lhj.1_Missense_Mutation_p.R733W	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	733	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGTGCACACGGGGCAAGCC	0.662000													15	33					0	0	0	0
PCDHB1	29930	broad.mit.edu	37	5	140433131	140433131	+	Silent	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:140433131C>A	uc003lik.1	+	1	2153	c.2076C>A	c.(2074-2076)GTC>GTA	p.V692V		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	692	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AATATTTGGTCATTTCTCTGG	0.388000													22	82					1.96895e-08	3.65337e-08	1	0
PCDHGA5	56110	broad.mit.edu	37	5	140746180	140746180	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:140746180G>A	uc003lju.1	+	1	2283	c.2283G>A	c.(2281-2283)GCG>GCA	p.A761A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Silent_p.A761A	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	761	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCTCACCGCGGACTCGAGGA	0.592000													13	136					0	0	0	0
PCDHGB6	56100	broad.mit.edu	37	5	140789449	140789449	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:140789449G>A	uc003lkj.1	+	1	1680	c.1680G>A	c.(1678-1680)CCG>CCA	p.P560P	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Silent_p.P560P	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	560	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAACGCACCGCGGGTGCTGT	0.662000													6	22					0	0	0	0
SPARC	6678	broad.mit.edu	37	5	151052775	151052775	+	Silent	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:151052775T>C	uc003luh.2	-	3	147	c.123A>G	c.(121-123)GTA>GTG	p.V41V	GM2A_uc011dcs.1_Intron|SPARC_uc003lug.2_5'UTR|SPARC_uc003lui.2_Silent_p.V41V	NM_003118	NP_003109	P09486	SPRC_HUMAN	secreted protein, acidic, cysteine-rich	41	Asp/Glu-rich (acidic; binds calcium).				ossification|platelet activation|platelet degranulation|signal transduction	basement membrane|extracellular space|platelet alpha granule lumen	calcium ion binding|collagen binding			central_nervous_system(1)	1		Medulloblastoma(196;0.109)|all_hematologic(541;0.122)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;0.00118)	Becaplermin(DB00102)	CTCCCACAGATACCTGGAATT	0.522000													34	67					0	0	0	0
HK3	3101	broad.mit.edu	37	5	176308467	176308467	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:176308467G>A	uc003mfa.2	-	18	2555	c.2463C>T	c.(2461-2463)GAC>GAT	p.D821D	HK3_uc003mez.2_Silent_p.D377D	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	821	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCATCAGGGCGTCATCTGAGG	0.652000													9	17					0	0	0	0
FLT4	2324	broad.mit.edu	37	5	180057046	180057046	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:180057046C>A	uc003mma.3	-	5	652	c.573G>T	c.(571-573)ATG>ATT	p.M191I	FLT4_uc003mlz.3_Missense_Mutation_p.M191I|FLT4_uc003mmb.1_5'Flank|FLT4_uc011dgy.1_Missense_Mutation_p.M191I|FLT4_uc011dgz.1_Missense_Mutation_p.M191I|FLT4_uc011dha.1_Missense_Mutation_p.C175F	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	191	Ig-like C2-type 2.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TGGACACGAGCATGCCCCGCC	0.637000									Congenital_Hereditary_Lymphedema				7	29					1.58986e-06	2.93303e-06	1	0
SSR1	6745	broad.mit.edu	37	6	7301699	7301699	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:7301699G>T	uc003mxf.3	-	4	575	c.387C>A	c.(385-387)GAC>GAA	p.D129E	SSR1_uc003mxg.3_Intron|SSR1_uc010jny.2_Missense_Mutation_p.D129E	NM_003144	NP_003135	P43307	SSRA_HUMAN	signal sequence receptor, alpha precursor	129	Lumenal (Potential).				cotranslational protein targeting to membrane|positive regulation of cell proliferation	endoplasmic reticulum membrane|integral to membrane	signal sequence binding				0	Ovarian(93;0.0398)					AAAACTGGTAGTCCTGAGGAT	0.428000													23	57					3.7963e-18	7.34105e-18	1	0
OR10C1	442194	broad.mit.edu	37	6	29407891	29407891	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:29407891C>T	uc011dlp.1	+	1	99	c.99C>T	c.(97-99)ATC>ATT	p.I33I	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	33	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTCTCACTATCTACCTGCTGA	0.557000													31	59					0	0	0	0
NRM	11270	broad.mit.edu	37	6	30658649	30658649	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:30658649G>C	uc003nrc.2	-	1	121	c.103C>G	c.(103-105)CTT>GTT	p.L35V	KIAA1949_uc003nrb.3_5'Flank|NRM_uc003nrd.2_RNA|NRM_uc003nre.2_5'UTR	NM_007243	NP_009174	Q8IXM6	NRM_HUMAN	nurim	35	Perinuclear space (Potential).					integral to membrane|nuclear inner membrane					0						ATCCCTCCAAGAAGTGGCCGA	0.642000													21	47					0	0	0	0
CYP21A2	1589	broad.mit.edu	37	6	32007955	32007955	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:32007955C>T	uc003nze.1	+	7	1030	c.912C>T	c.(910-912)GCC>GCT	p.A304A	CYP21A2_uc003nzf.1_Silent_p.A274A	NM_000500	NP_000491	P08686	CP21A_HUMAN	cytochrome P450, family 21, subfamily A,	303					glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding				0						TCTCCTGGGCCGTGGTTTTTT	0.617000													30	111					0	0	0	0
FKBPL	63943	broad.mit.edu	37	6	32097359	32097359	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:32097359C>T	uc003nzr.2	-	2	469	c.199G>A	c.(199-201)GAA>AAA	p.E67K	ATF6B_uc003nzo.2_5'Flank|ATF6B_uc003nzn.2_5'Flank|ATF6B_uc011dpg.1_5'Flank|ATF6B_uc011dph.1_5'Flank	NM_022110	NP_071393	Q9UIM3	FKBPL_HUMAN	WAF-1/CIP1 stabilizing protein 39	67					response to radiation	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0						ACCAGTTTTTCAGCTCCTTGA	0.512000													11	66					0	0	0	0
DNAH8	1769	broad.mit.edu	37	6	38821072	38821072	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:38821072C>G	uc003ooe.1	+	39	5631	c.5031C>G	c.(5029-5031)ATC>ATG	p.I1677M		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TCTATCAAATCAGTGATTCAG	0.368000													19	32					0	0	0	0
BYSL	705	broad.mit.edu	37	6	41900357	41900357	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:41900357C>T	uc003orl.2	+	7	1563	c.1227C>T	c.(1225-1227)CCC>CCT	p.P409P		NM_004053	NP_004044	Q13895	BYST_HUMAN	bystin	409					cell adhesion|female pregnancy|ribosome biogenesis	cytoplasm|nucleolus					0	Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000473)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GGCTGCAGCCCCATCCACAGC	0.587000													12	64					0	0	0	0
SENP6	26054	broad.mit.edu	37	6	76344432	76344433	+	Nonsense_Mutation	DNP	GC	TT	TT			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:76344432_76344433GC>TT	uc003pid.3	+	5	982_983	c.363_364GC>TT	c.(361-366)ACGCAA>ACTTAA	p.Q122*	SENP6_uc003pie.3_Nonsense_Mutation_p.Q122*|SENP6_uc003pic.2_Nonsense_Mutation_p.Q122*|SENP6_uc003pif.1_Nonsense_Mutation_p.Q13*	NM_015571	NP_056386	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6 isoform 1	122					proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|urinary_tract(1)|ovary(1)|lung(1)|skin(1)	6		all_hematologic(105;0.189)				GTGAAAATACGCAAAATACGTC	0.322000													8	17					0	0	0	0
PREP	5550	broad.mit.edu	37	6	105816838	105816838	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:105816838C>A	uc003prc.2	-	6	860	c.657G>T	c.(655-657)CAG>CAT	p.Q219H		NM_002726	NP_002717	P48147	PPCE_HUMAN	prolyl endopeptidase	219					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)	TATCTTCTGACTGATCGGTTC	0.418000													23	33					5.35356e-11	1.00204e-10	1	0
FRK	2444	broad.mit.edu	37	6	116265528	116265528	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:116265528G>A	uc003pwi.1	-	6	1466	c.1019C>T	c.(1018-1020)TCT>TTT	p.S340F		NM_002031	NP_002022	P42685	FRK_HUMAN	fyn-related kinase	340	Protein kinase.				negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|lung(3)	6		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		GGCCATTCCAGAGGCAACCTG	0.418000													10	40					0	0	0	0
GRM1	2911	broad.mit.edu	37	6	146720758	146720758	+	Silent	SNP	C	T	T	rs148042148		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:146720758C>T	uc010khw.1	+	8	3053	c.2583C>T	c.(2581-2583)GGC>GGT	p.G861G	GRM1_uc010khv.1_Silent_p.G861G|GRM1_uc003qll.2_Silent_p.G861G|GRM1_uc011edz.1_Silent_p.G861G|GRM1_uc011eea.1_Silent_p.G861G	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	861	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TGCATGTTGGCGATGGCAAGC	0.517000													12	25					0	0	0	0
TAB2	23118	broad.mit.edu	37	6	149699950	149699950	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:149699950C>T	uc003qmj.2	+	3	1077	c.899C>T	c.(898-900)TCA>TTA	p.S300L	TAB2_uc011eec.1_Missense_Mutation_p.S268L|TAB2_uc010kia.1_Missense_Mutation_p.S300L|TAB2_uc010kib.1_Missense_Mutation_p.S300L|TAB2_uc003qmk.3_RNA	NM_015093	NP_055908	Q9NYJ8	TAB2_HUMAN	mitogen-activated protein kinase kinase kinase 7	300					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding				0						ACCATTCATTCATCTGGTAGC	0.433000													9	82					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152737810	152737810	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:152737810G>A	uc010kiw.2	-	41	6364	c.5762C>T	c.(5761-5763)TCT>TTT	p.S1921F	SYNE1_uc003qot.3_Missense_Mutation_p.S1928F|SYNE1_uc003qou.3_Missense_Mutation_p.S1921F|SYNE1_uc010kjb.1_Missense_Mutation_p.S1904F	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1921	Cytoplasmic (Potential).|Potential.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GACGGCAGCAGATTCTAATGC	0.453000										HNSCC(10;0.0054)			21	46					0	0	0	0
LPAL2	80350	broad.mit.edu	37	6	160899548	160899548	+	RNA	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:160899548G>C	uc003qtj.2	-	8		c.1337C>G			LPAL2_uc011efy.1_RNA	NR_028093				Homo sapiens cDNA FLJ43922 fis, clone TESTI4012406.												0		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.214)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)		ACCTGCTTCAGAATGAGCCTC	0.453000													9	47					0	0	0	0
PDE10A	10846	broad.mit.edu	37	6	165792780	165792780	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:165792780T>A	uc003qun.2	-	19	2099	c.1858A>T	c.(1858-1860)ATC>TTC	p.I620F	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.I550F|PDE10A_uc003quo.2_Missense_Mutation_p.I630F	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	620					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	GTGGCAATGATGGCTTTGCGG	0.413000													7	41					0	0	0	0
SFRP4	6424	broad.mit.edu	37	7	37956080	37956080	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:37956080G>A	uc003tfo.3	-	1	446	c.60C>T	c.(58-60)CGC>CGT	p.R20R		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	20	FZ.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						AGGGCGCGCCGCGCACGCCCA	0.682000													19	32					0	0	0	0
ABCA13	154664	broad.mit.edu	37	7	48318187	48318187	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:48318187C>G	uc003toq.2	+	18	7421	c.7396C>G	c.(7396-7398)CTA>GTA	p.L2466V	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2466					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TTCATTCCCTCTAAGAAACAG	0.358000													12	129					0	0	0	0
WBSCR17	64409	broad.mit.edu	37	7	70853278	70853278	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:70853278C>G	uc003tvy.2	+	3	480	c.480C>G	c.(478-480)TTC>TTG	p.F160L	WBSCR17_uc003tvz.2_5'UTR	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	160	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				TATTCATCTTCGTGAACGAGG	0.527000													6	67					0	0	0	0
PCLO	27445	broad.mit.edu	37	7	82475906	82475906	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:82475906T>A	uc003uhx.2	-	12	14097	c.13808A>T	c.(13807-13809)GAA>GTA	p.E4603V	PCLO_uc003uhv.2_Missense_Mutation_p.E4603V|PCLO_uc003uht.1_Missense_Mutation_p.E54V|PCLO_uc003uhu.1_Missense_Mutation_p.E33V	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4491					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTCATGAAGTTCCAGATGCTG	0.338000													19	17					0	0	0	0
RUNDC3B	154661	broad.mit.edu	37	7	87258202	87258202	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:87258202G>C	uc003ujb.2	+	1	474	c.63G>C	c.(61-63)AAG>AAC	p.K21N	ABCB1_uc003uiz.1_Intron|ABCB1_uc003uja.1_Intron|ABCB1_uc010lei.1_Intron|RUNDC3B_uc011khd.1_Missense_Mutation_p.K21N|RUNDC3B_uc011khe.1_Missense_Mutation_p.K21N|RUNDC3B_uc003ujc.2_Missense_Mutation_p.K21N	NM_138290	NP_612147	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B isoform a	21										skin(1)	1	Esophageal squamous(14;0.00164)					GAGGCGGCAAGAAAAGCCTGA	0.716000													4	11					0	0	0	0
CYP3A7	1551	broad.mit.edu	37	7	99306662	99306662	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:99306662C>T	uc003uru.2	-	11	1354	c.1249G>A	c.(1249-1251)GAA>AAA	p.E417K	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,	417					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					TCCTACCTTTCAGGGAGGAAC	0.512000													18	89					0	0	0	0
MUC17	140453	broad.mit.edu	37	7	100676630	100676630	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:100676630G>C	uc003uxp.1	+	3	1986	c.1933G>C	c.(1933-1935)GAG>CAG	p.E645Q	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	645	Extracellular (Potential).|8.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GGCCAGTTCTGAGGCTAGCAC	0.483000													115	469					0	0	0	0
C7orf66	154907	broad.mit.edu	37	7	108524578	108524578	+	Silent	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:108524578C>G	uc003vfo.2	-	1	60	c.12G>C	c.(10-12)GTG>GTC	p.V4V		NM_001024607	NP_001019778	A4D0T2	CG066_HUMAN	hypothetical protein LOC154907	4						integral to membrane				ovary(2)	2						TGGGTGTCATCACAGCCATCA	0.413000													3	54					0	0	0	0
C7orf58	79974	broad.mit.edu	37	7	120764400	120764400	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:120764400G>C	uc003vjq.3	+	8	1381	c.934G>C	c.(934-936)GAG>CAG	p.E312Q	C7orf58_uc003vjr.1_Missense_Mutation_p.E312Q|C7orf58_uc003vjs.3_Missense_Mutation_p.E312Q|C7orf58_uc003vjt.3_Missense_Mutation_p.E92Q|C7orf58_uc010lkk.1_Missense_Mutation_p.E92Q	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	312						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					AACATTTTTTGAGACATTCCT	0.393000													16	53					0	0	0	0
FSCN3	29999	broad.mit.edu	37	7	127240328	127240328	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:127240328G>A	uc003vmd.1	+	6	1591	c.1372G>A	c.(1372-1374)GAG>AAG	p.E458K	FSCN3_uc011koh.1_Missense_Mutation_p.R322Q|FSCN3_uc010llc.1_Missense_Mutation_p.R456Q	NM_020369	NP_065102	Q9NQT6	FSCN3_HUMAN	fascin 3	458						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			ovary(1)	1						CTTCTGTATCGAGCTTCAGGG	0.537000													6	59					0	0	0	0
LRGUK	136332	broad.mit.edu	37	7	133812362	133812362	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:133812362G>A	uc003vrm.1	+	1	258	c.242G>A	c.(241-243)GGC>GAC	p.G81D		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	81							ATP binding|kinase activity			lung(2)|skin(2)|kidney(1)	5						GAGGACCAGGGCGAGGGCGAG	0.612000													7	40					0	0	0	0
KIAA1549	57670	broad.mit.edu	37	7	138603487	138603487	+	Silent	SNP	G	A	A	rs79934303	by1000genomes	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:138603487G>A	uc011kql.1	-	2	934	c.885C>T	c.(883-885)GAC>GAT	p.D295D	KIAA1549_uc003vuk.3_Silent_p.D245D|KIAA1549_uc011kqj.1_Silent_p.D295D	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	295						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						TAGTAATGCCGTCGCCTAACG	0.537000			O	BRAF	pilocytic astrocytoma								16	54					0	0	0	0
PARP12	64761	broad.mit.edu	37	7	139727113	139727113	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:139727113G>A	uc003vvl.1	-	10	2465	c.1591C>T	c.(1591-1593)CGA>TGA	p.R531*	PARP12_uc003vvk.1_Nonsense_Mutation_p.R317*|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	531	PARP catalytic.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					TTCTGTACTCGCTCAATCTTC	0.537000													5	42					0	0	0	0
ADCK2	90956	broad.mit.edu	37	7	140373236	140373236	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:140373236G>T	uc003vvy.1	+	1	284	c.106G>T	c.(106-108)GAT>TAT	p.D36Y	ADCK2_uc003vvz.2_Missense_Mutation_p.D36Y	NM_052853	NP_443085	Q7Z695	ADCK2_HUMAN	aarF domain containing kinase 2	36						integral to membrane	ATP binding|protein serine/threonine kinase activity				0	Melanoma(164;0.00956)					GTGCCCTCGCGATGCCAGGCT	0.677000													6	12					0.00116845	0.00210714	1	0
KEL	3792	broad.mit.edu	37	7	142643301	142643301	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:142643301C>T	uc003wcb.2	-	11	1517	c.1307G>A	c.(1306-1308)CGA>CAA	p.R436Q		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	436	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					TACAGCACTTCGGGTGCTCGG	0.577000													8	11					0	0	0	0
CSMD1	64478	broad.mit.edu	37	8	3267046	3267046	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:3267046G>T	uc011kwk.1	-	13	2036	c.1646C>A	c.(1645-1647)ACA>AAA	p.T549K	CSMD1_uc011kwj.1_5'UTR	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	549	Extracellular (Potential).|Sushi 3.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AAAGGTGAGTGTATCTCCATG	0.527000													4	5					0.000602214	0.00108908	1	0
DEFA4	1669	broad.mit.edu	37	8	6794410	6794410	+	Missense_Mutation	SNP	G	C	C	rs61749084	byFrequency	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:6794410G>C	uc003wqu.1	-	2	63	c.12C>G	c.(10-12)ATC>ATG	p.I4M		NM_001925	NP_001916	P12838	DEF4_HUMAN	defensin, alpha 4 preproprotein	4					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				large_intestine(1)	1				COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		CGAGGAGGGCGATAATCCTCA	0.622000													4	9					0	0	0	0
KIF13B	23303	broad.mit.edu	37	8	28974435	28974435	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:28974435G>A	uc003xhh.3	-	31	3809	c.3750C>T	c.(3748-3750)ATC>ATT	p.I1250I	uc003xhi.1_Intron	NM_015254	NP_056069	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	1250					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		TCACGCGCACGATCAGGAACA	0.602000													26	63					0	0	0	0
IKBKB	3551	broad.mit.edu	37	8	42179657	42179657	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:42179657C>G	uc003xow.1	+	18	2001	c.1824C>G	c.(1822-1824)ATC>ATG	p.I608M	IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Missense_Mutation_p.I385M|IKBKB_uc003xox.1_Missense_Mutation_p.I329M|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Missense_Mutation_p.I606M|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Missense_Mutation_p.I549M	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	608					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	TGCGAGTGATCTATACGCAGC	0.557000													8	63					0	0	0	0
MOS	4342	broad.mit.edu	37	8	57025647	57025648	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:57025647_57025648GG>AA	uc011leb.1	-	1	894_895	c.894_895CC>TT	c.(892-897)TCCCTC>TCTTTC	p.L299F		NM_005372	NP_005363	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene	299	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|ovary(1)|central_nervous_system(1)	4			Epithelial(17;0.00117)|all cancers(17;0.00879)			GCAGCGGAGAGGGACGGGCGCA	0.683000													9	31					0	0	0	0
MYBL1	4603	broad.mit.edu	37	8	67514655	67514655	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:67514655C>T	uc003xwj.2	-	2	531	c.124G>A	c.(124-126)GAG>AAG	p.E42K	MYBL1_uc003xwl.2_Missense_Mutation_p.E42K|MYBL1_uc003xwk.2_Missense_Mutation_p.E42K	NM_001080416	NP_001073885	P10243	MYBA_HUMAN	v-myb myeloblastosis viral oncogene homolog	42	HTH myb-type 1.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)	3			Epithelial(68;0.00211)|all cancers(69;0.00726)|OV - Ovarian serous cystadenocarcinoma(28;0.00989)|BRCA - Breast invasive adenocarcinoma(89;0.0938)			ATAATTACCTCGTCCCTTGTC	0.308000													16	45					0	0	0	0
CSPP1	79848	broad.mit.edu	37	8	68007843	68007843	+	Missense_Mutation	SNP	C	T	T	rs114953032	by1000genomes	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:68007843C>T	uc003xxi.2	+	8	962	c.931C>T	c.(931-933)CGT>TGT	p.R311C	CSPP1_uc003xxg.1_Missense_Mutation_p.R303C|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.R276C|CSPP1_uc003xxk.2_5'UTR	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	311						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			TAATGAGGATCGTGTTTTTGA	0.373000													6	34					0	0	0	0
PRDM14	63978	broad.mit.edu	37	8	70964454	70964454	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:70964454G>C	uc003xym.2	-	8	1776	c.1574C>G	c.(1573-1575)TCT>TGT	p.S525C		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	525	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			GGATGCAAAAGATTTACCACA	0.517000													19	121					0	0	0	0
ZFHX4	79776	broad.mit.edu	37	8	77775694	77775694	+	Silent	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:77775694T>C	uc003yav.2	+	11	9996	c.9609T>C	c.(9607-9609)AAT>AAC	p.N3203N		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3199						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CATTACAGAATGCAATTGCTG	0.443000										HNSCC(33;0.089)			39	134					0	0	0	0
CNGB3	54714	broad.mit.edu	37	8	87645041	87645041	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:87645041A>G	uc003ydx.2	-	11	1305	c.1259T>C	c.(1258-1260)ATT>ACT	p.I420T	CNGB3_uc010maj.2_Missense_Mutation_p.I282T	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	420	Helical; Name=H5; (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						TTGAAAAACAATTTCAAATAA	0.353000													14	19					0	0	0	0
CNGB3	54714	broad.mit.edu	37	8	87738776	87738776	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:87738776C>T	uc003ydx.2	-	3	367	c.321G>A	c.(319-321)GGG>GGA	p.G107G		NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	107	Cytoplasmic (Potential).		G -> R (in ACHM3; uncertain pathogenicity).		signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						GACCTTCTTTCCCGGGGTCCA	0.453000													64	241					0	0	0	0
OSGIN2	734	broad.mit.edu	37	8	90937360	90937360	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:90937360C>T	uc003yeg.2	+	6	1464	c.1118C>T	c.(1117-1119)TCT>TTT	p.S373F	OSGIN2_uc003yeh.2_Missense_Mutation_p.S417F	NM_004337	NP_004328	Q9Y236	OSGI2_HUMAN	oxidative stress induced growth inhibitor family	373					germ cell development|meiosis						0			BRCA - Breast invasive adenocarcinoma(11;0.0344)			AATCTTTTATCTGATTATACC	0.358000													14	152					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113364752	113364752	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:113364752C>A	uc003ynu.2	-	39	6307	c.6148G>T	c.(6148-6150)GAT>TAT	p.D2050Y	CSMD3_uc003yns.2_Missense_Mutation_p.D1252Y|CSMD3_uc003ynt.2_Missense_Mutation_p.D2010Y|CSMD3_uc011lhx.1_Missense_Mutation_p.D1946Y	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2050	Extracellular (Potential).|Sushi 11.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGACAGGAATCCAAACCAATT	0.318000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			10	70					2.17888e-05	3.99668e-05	1	0
ZFAT	57623	broad.mit.edu	37	8	135612760	135612760	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:135612760C>T	uc003yup.2	-	7	2569	c.2394G>A	c.(2392-2394)CTG>CTA	p.L798L	ZFAT_uc003yun.2_Silent_p.L786L|ZFAT_uc003yuo.2_Silent_p.L786L|ZFAT_uc010meh.2_Silent_p.L786L|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Silent_p.L786L|ZFAT_uc010mej.2_Silent_p.L736L|ZFAT_uc003yur.2_Silent_p.L786L|ZFATAS_uc003yus.1_RNA	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	798	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			TGGGACACTTCAGCAAGATGT	0.438000													26	109					0	0	0	0
RHPN1	114822	broad.mit.edu	37	8	144464817	144464817	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:144464817C>T	uc003yyb.2	+	15	2142	c.2009C>T	c.(2008-2010)CCG>CTG	p.P670L		NM_052924	NP_443156	Q8TCX5	RHPN1_HUMAN	rhophilin 1	695					signal transduction	intracellular				large_intestine(1)	1	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			CCAGGGTGGCCGTGAGGGCCA	0.687000													16	14					0	0	0	0
PLEC	5339	broad.mit.edu	37	8	144996395	144996395	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:144996395C>G	uc003zaf.1	-	32	8175	c.8005G>C	c.(8005-8007)GAG>CAG	p.E2669Q	PLEC_uc003zab.1_Missense_Mutation_p.E2532Q|PLEC_uc003zac.1_Missense_Mutation_p.E2536Q|PLEC_uc003zad.2_Missense_Mutation_p.E2532Q|PLEC_uc003zae.1_Missense_Mutation_p.E2500Q|PLEC_uc003zag.1_Missense_Mutation_p.E2510Q|PLEC_uc003zah.2_Missense_Mutation_p.E2518Q|PLEC_uc003zaj.2_Missense_Mutation_p.E2559Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2669	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						tgctgctCCTCACGCAGCTGC	0.517000													3	12					0	0	0	0
PSIP1	11168	broad.mit.edu	37	9	15469058	15469058	+	Splice_Site	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr9:15469058T>C	uc003zlv.3	-	13	1435	c.1105_splice	c.e13-1	p.D369_splice	PSIP1_uc003zlw.3_Splice_Site_p.D369_splice	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2						initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		GTTCACATCCTTCATGACAAA	0.353000													11	18					0	0	0	0
DCAF12	25853	broad.mit.edu	37	9	34098412	34098412	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr9:34098412G>C	uc003ztt.2	-	5	1047	c.705C>G	c.(703-705)ATC>ATG	p.I235M		NM_015397	NP_056212	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	235						centrosome|CUL4 RING ubiquitin ligase complex					0						CCTTGTGAGTGATGTGTGCAT	0.483000													7	108					0	0	0	0
C9orf79	286234	broad.mit.edu	37	9	90502856	90502856	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr9:90502856A>G	uc004app.3	+	4	3489	c.3454A>G	c.(3454-3456)ACC>GCC	p.T1152A		NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	1152						integral to membrane				ovary(3)	3						CCCTCTGTCCACCTCCCAGAG	0.642000													8	32					0	0	0	0
KIAA1529	57653	broad.mit.edu	37	9	100136864	100136864	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr9:100136864G>A	uc011lut.1	+	47	5962	c.5189G>A	c.(5188-5190)CGA>CAA	p.R1730Q	KIAA1529_uc004axe.1_Missense_Mutation_p.R1536Q|KIAA1529_uc004axg.1_Missense_Mutation_p.R1591Q|KIAA1529_uc004axh.1_RNA|KIAA1529_uc011luw.1_Missense_Mutation_p.R684Q	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				ATGCTCATACGAAGGAAACTC	0.507000													4	22					0	0	0	0
SVEP1	79987	broad.mit.edu	37	9	113169482	113169482	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr9:113169482C>G	uc010mtz.2	-	38	8735	c.8398G>C	c.(8398-8400)GAG>CAG	p.E2800Q	SVEP1_uc010mty.2_Missense_Mutation_p.E726Q	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2800	Sushi 23.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GGGTCACACTCATAGTACAAC	0.483000													76	52					0	0	0	0
LAMC3	10319	broad.mit.edu	37	9	133957539	133957539	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr9:133957539G>C	uc004caa.1	+	24	4119	c.4021G>C	c.(4021-4023)GAT>CAT	p.D1341H	LAMC3_uc010mze.1_Missense_Mutation_p.D57H	NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	1341	Domain II and I.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		TCTGCTGGCTGATCTGGAAGG	0.617000													13	5					0	0	0	0
C9orf96	169436	broad.mit.edu	37	9	136253248	136253248	+	Silent	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr9:136253248C>G	uc004cdk.2	+	5	373	c.312C>G	c.(310-312)CTC>CTG	p.L104L	C9orf96_uc004cdl.2_RNA	NM_153710	NP_714921	Q8NE28	SGK71_HUMAN	hypothetical protein LOC169436	104	Protein kinase.						ATP binding|protein kinase activity			stomach(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		CTCTGTACCTCTGCCTGGTGA	0.572000													12	55					0	0	0	0
PHPT1	29085	broad.mit.edu	37	9	139744530	139744530	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr9:139744530G>A	uc004cjp.2	+	3	848	c.226G>A	c.(226-228)GGC>AGC	p.G76S	PHPT1_uc011mei.1_Missense_Mutation_p.G76S|PHPT1_uc004cjq.3_Missense_Mutation_p.G76S|MAMDC4_uc004cjs.2_5'Flank|MAMDC4_uc011mej.1_5'Flank	NM_014172	NP_054891	Q9NRX4	PHP14_HUMAN	phosphohistidine phosphatase 1 isoform 3	76						cytosol	phosphohistidine phosphatase activity|phosphoprotein phosphatase activity				0	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		GTGTCTGGGCGGCGGGCGCAT	0.647000													47	20					0	0	0	0
C8G	733	broad.mit.edu	37	9	139840948	139840948	+	Silent	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr9:139840948G>C	uc004cka.2	+	5	561	c.486G>C	c.(484-486)CTG>CTC	p.L162L	FBXW5_uc004cjx.2_5'Flank|FBXW5_uc004cjy.2_5'Flank|FBXW5_uc004cjz.2_5'Flank	NM_000606	NP_000597	P07360	CO8G_HUMAN	complement component 8, gamma polypeptide	162					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex	retinol binding|transporter activity				0	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.88e-06)|Epithelial(140;0.000107)		ACTCGGTCCTGAGTGGGTTTG	0.657000													3	19					0	0	0	0
RNF208	727800	broad.mit.edu	37	9	140115259	140115259	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr9:140115259C>T	uc004clz.1	-	1	517	c.406G>A	c.(406-408)GCG>ACG	p.A136T		NM_031297	NP_112587	Q9H0X6	RN208_HUMAN	ring finger protein 208	136							zinc ion binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		TCGCCTGCCGCCGCCGAAGAA	0.672000													23	11					0	0	0	0
ASMTL	8623	broad.mit.edu	37	X	1554652	1554652	+	Splice_Site	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:1554652C>T	uc004cpx.1	-	4	385	c.274_splice	c.e4-1	p.T92_splice	ASMTL_uc011mhe.1_Intron|ASMTL_uc004cpy.1_Splice_Site_p.T76_splice|ASMTL_uc011mhf.1_Splice_Site_p.T34_splice	NM_004192	NP_004183	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like						melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CCCCGACTGTCTGTGAGAGGA	0.587000													11	69					0	0	0	0
CNKSR2	22866	broad.mit.edu	37	X	21545080	21545080	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:21545080C>T	uc004czx.1	+	10	1089	c.1053C>T	c.(1051-1053)CTC>CTT	p.L351L	CNKSR2_uc004czw.2_Silent_p.L351L|CNKSR2_uc011mjn.1_Silent_p.L302L|CNKSR2_uc011mjo.1_Silent_p.L351L|CNKSR2_uc004czy.2_5'UTR	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	351	DUF1170.				regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						TCCAGGATCTCTACATTCCCC	0.483000													16	137					0	0	0	0
MID1IP1	58526	broad.mit.edu	37	X	38664680	38664680	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:38664680C>G	uc004dei.3	+	3	905	c.481C>G	c.(481-483)CTC>GTC	p.L161V	MID1IP1_uc010ngz.2_Missense_Mutation_p.L161V|MID1IP1_uc004dej.3_Missense_Mutation_p.L161V	NM_001098790	NP_001092260	Q9NPA3	M1IP1_HUMAN	MID1 interacting G12-like protein	161					lipid biosynthetic process|negative regulation of microtubule depolymerization|positive regulation of fatty acid biosynthetic process|positive regulation of ligase activity|protein polymerization	cytosol|microtubule|nucleus					0						GCTCTCGAAACTCACGCGCAA	0.627000													11	7					0	0	0	0
ATP6AP2	10159	broad.mit.edu	37	X	40456555	40456555	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:40456555G>C	uc004det.2	+	4	457	c.355G>C	c.(355-357)GAG>CAG	p.E119Q	ATP6AP2_uc010nhc.2_RNA|ATP6AP2_uc011mkl.1_Missense_Mutation_p.E43Q|ATP6AP2_uc011mkm.1_Intron|ATP6AP2_uc011mkn.1_Intron|ATP6AP2_uc004deu.1_5'Flank	NM_005765	NP_005756	O75787	RENR_HUMAN	ATPase, H+ transporting, lysosomal accessory	119	Extracellular (Potential).				angiotensin maturation|positive regulation of transforming growth factor-beta1 production|regulation of MAPKKK cascade	external side of plasma membrane|integral to membrane	protein binding|receptor activity				0						CTTATTTTCTGAGGAAACTCC	0.323000													8	21					0	0	0	0
UBA1	7317	broad.mit.edu	37	X	47074277	47074277	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:47074277C>T	uc004dhj.3	+	26	3277	c.3126C>T	c.(3124-3126)GAC>GAT	p.D1042D	UBA1_uc004dhk.3_Silent_p.D1042D|UBA1_uc004dhm.2_Silent_p.D490D	NM_153280	NP_695012	P22314	UBA1_HUMAN	ubiquitin-activating enzyme E1	1042					cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			ovary(1)	1						GCTGTAACGACGAGAGCGGCG	0.627000													23	16					0	0	0	0
UBQLN2	29978	broad.mit.edu	37	X	56591223	56591223	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:56591223A>T	uc004dus.2	+	1	1152	c.917A>T	c.(916-918)CAG>CTG	p.Q306L	UBQLN2_uc011moq.1_Missense_Mutation_p.Q306L	NM_013444	NP_038472	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	306						cytoplasm|nucleus|plasma membrane	binding			ovary(1)|skin(1)	2						GAAGGTACGCAGCCTTCCCGC	0.562000													11	3					0	0	0	0
ARR3	407	broad.mit.edu	37	X	69489243	69489243	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:69489243A>C	uc004dyb.2	+	2	76	c.8A>C	c.(7-9)AAG>ACG	p.K3T	ARR3_uc004dya.2_Missense_Mutation_p.K3T	NM_004312	NP_004303	P36575	ARRC_HUMAN	arrestin 3, retinal (X-arrestin)	3					signal transduction|visual perception	cytoplasm|soluble fraction				large_intestine(2)|ovary(2)	4						AACATGTCCAAGTAAGAATTC	0.423000													11	5					0	0	0	0
PGAM4	441531	broad.mit.edu	37	X	77224532	77224532	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:77224532C>G	uc004ecy.1	-	1	604	c.604G>C	c.(604-606)GAA>CAA	p.E202Q	ATP7A_uc004ecw.2_Intron|ATP7A_uc004ecx.3_Intron	NM_001029891	NP_001025062	Q8N0Y7	PGAM4_HUMAN	bisphosphoglycerate mutase 4	202					glycolysis		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity				0						ATAGCCTCTTCAGAGAGACCC	0.512000													4	179					0	0	0	0
NAP1L3	4675	broad.mit.edu	37	X	92927456	92927456	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:92927456C>G	uc004efq.2	-	1	1153	c.848G>C	c.(847-849)AGA>ACA	p.R283T	FAM133A_uc004efr.1_5'Flank	NM_004538	NP_004529	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	283					nucleosome assembly	chromatin assembly complex				ovary(1)|skin(1)	2						CTCAGGAACTCTTTTATGAGT	0.453000													3	87					0	0	0	0
TCEAL4	79921	broad.mit.edu	37	X	102842017	102842017	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:102842017C>T	uc004ekl.2	+	3	707	c.414C>T	c.(412-414)CTC>CTT	p.L138L	TCEAL4_uc004ekn.2_Silent_p.L138L|TCEAL4_uc004ekm.2_Silent_p.L138L|TCEAL4_uc004eko.2_Silent_p.L138L	NM_024863	NP_079139	Q96EI5	TCAL4_HUMAN	transcription elongation factor A (SII)-like 4	138					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						CTCATTACCTCAAGGAGTATA	0.433000													11	117					0	0	0	0
PLP1	5354	broad.mit.edu	37	X	103041526	103041526	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:103041526C>T	uc010nov.2	+	4	604	c.324C>T	c.(322-324)ATC>ATT	p.I108I	RAB9B_uc004eli.1_Intron|PLP1_uc004elk.2_Silent_p.I108I|PLP1_uc004elj.2_Silent_p.I108I|PLP1_uc011msf.1_Silent_p.I53I|PLP1_uc010now.1_Silent_p.I112I|PLP1_uc010nox.2_Silent_p.I62I	NM_001128834	NP_001122306	P60201	MYPR_HUMAN	proteolipid protein 1 isoform 1	108	Cytoplasmic (Probable).				cell death|synaptic transmission	integral to membrane				ovary(1)	1						AGACCACCATCTGCGGCAAGG	0.582000													12	110					0	0	0	0
SERPINA7	6906	broad.mit.edu	37	X	105280474	105280474	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:105280474G>A	uc004eme.1	-	1	592	c.576C>T	c.(574-576)CTC>CTT	p.L192L	SERPINA7_uc010npd.2_Silent_p.L192L|SERPINA7_uc010npe.1_Silent_p.L192L	NM_000354	NP_000345	P05543	THBG_HUMAN	serine (or cysteine) proteinase inhibitor, clade	192					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity				0					Levothyroxine(DB00451)|Liothyronine(DB00279)	TGTTTGGCTTGAGGTCTTGAA	0.418000													18	103					0	0	0	0
CHRDL1	91851	broad.mit.edu	37	X	109922601	109922601	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:109922601C>T	uc004eou.3	-	11	1558	c.1209G>A	c.(1207-1209)GAG>GAA	p.E403E	CHRDL1_uc004eov.2_Silent_p.E392E|CHRDL1_uc004eow.2_Silent_p.E401E|CHRDL1_uc010nps.2_Silent_p.E402E|CHRDL1_uc004eot.2_Silent_p.E322E|CHRDL1_uc011mss.1_Silent_p.E317E	NM_001143981	NP_001137453	Q9BU40	CRDL1_HUMAN	chordin-like 1 isoform 1 precursor	395					BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region					0						AGTGAGGAAGCTCCTCAAACA	0.453000													45	15					0	0	0	0
GPC4	2239	broad.mit.edu	37	X	132548982	132548982	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:132548982G>A	uc004exc.1	-	1	224	c.12C>T	c.(10-12)TTC>TTT	p.F4F	GPC4_uc011mvg.1_5'Flank	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	4					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					CGGGCAAGCCGAACCGTGCCA	0.701000													7	20					0	0	0	0
ATP2B3	492	broad.mit.edu	37	X	152845713	152845713	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:152845713C>G	uc004fht.1	+	20	3746	c.3620C>G	c.(3619-3621)TCC>TGC	p.S1207C	ATP2B3_uc004fhs.1_3'UTR|ATP2B3_uc010nuf.1_Missense_Mutation_p.S344C|ATP2B3_uc004fhu.1_Missense_Mutation_p.S159C	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	1207	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTGTTTTCCTCCAGTCCCGGG	0.473000													3	75					0	0	0	0
KDM5D	8284	broad.mit.edu	37	Y	21877710	21877710	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrY:21877710G>A	uc004fug.2	-	16	2500	c.2212C>T	c.(2212-2214)CGG>TGG	p.R738W	KDM5D_uc011naz.1_Missense_Mutation_p.R769W|KDM5D_uc010nwy.2_Missense_Mutation_p.R681W|KDM5D_uc011nba.1_Missense_Mutation_p.R738W|KDM5D_uc004fuf.2_5'Flank	NM_004653	NP_004644	Q9BY66	KDM5D_HUMAN	jumonji, AT rich interactive domain 1D isoform	738					chromatin modification|spermatogenesis	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1					Vitamin C(DB00126)	CATGCTCACCGGAGGTACTGT	0.552000													67	9					0	0	0	0
AGRN	375790	broad.mit.edu	37	1	978800	978800	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:978800C>T	uc001ack.1	+	8	1616	c.1566C>T	c.(1564-1566)CTC>CTT	p.L522L		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	522	Kazal-like 5.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CCTGTACCCTCGGGCGGGAGA	0.682000													5	16					0	0	0	0
FBXO42	54455	broad.mit.edu	37	1	16641805	16641805	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:16641805C>G	uc001ayg.2	-	2	325	c.109G>C	c.(109-111)GAG>CAG	p.E37Q	FBXO42_uc001ayf.2_5'UTR|FBXO42_uc001ayh.2_Missense_Mutation_p.E37Q	NM_018994	NP_061867	Q6P3S6	FBX42_HUMAN	F-box protein 42	37										upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		TCCTCAGCCTCCAATACTGGG	0.498000													5	52					0	0	0	0
PADI2	11240	broad.mit.edu	37	1	17397918	17397918	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:17397918C>T	uc001baf.2	-	14	1700	c.1618G>A	c.(1618-1620)GAG>AAG	p.E540K	PADI2_uc010ocm.1_Missense_Mutation_p.E424K	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	540					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	TACAGGTTCTCCTGCACAAGG	0.597000													15	39					0	0	0	0
PADI4	23569	broad.mit.edu	37	1	17662722	17662722	+	Splice_Site	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:17662722G>A	uc001baj.2	+	4	436	c.408_splice	c.e4+1	p.Q136_splice	PADI4_uc009vpc.2_Splice_Site_p.Q136_splice	NM_012387	NP_036519	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV						chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	GAAAGATCAGGTACCACTCAC	0.547000											OREG0013149	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	26					0	0	0	0
ALDH4A1	8659	broad.mit.edu	37	1	19204081	19204081	+	Silent	SNP	G	A	A	rs150927009		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:19204081G>A	uc001bbb.2	-	10	1242	c.966C>T	c.(964-966)TTC>TTT	p.F322F	ALDH4A1_uc010ocu.1_Silent_p.F262F|ALDH4A1_uc001bbc.2_Silent_p.F322F	NM_170726	NP_733844	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4A1 isoform a precursor	322					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	AGCGGTGCACGAAGTGGAAGT	0.657000													7	17					0	0	0	0
TMCO4	255104	broad.mit.edu	37	1	20107215	20107215	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:20107215G>C	uc001bcn.2	-	4	279	c.37C>G	c.(37-39)CAG>GAG	p.Q13E	TMCO4_uc001bcm.2_Missense_Mutation_p.Q13E|TMCO4_uc001bco.1_Missense_Mutation_p.Q13E|TMCO4_uc001bcp.1_Missense_Mutation_p.Q13E|TMCO4_uc009vpn.1_Missense_Mutation_p.Q13E|TMCO4_uc001bcq.1_Missense_Mutation_p.Q13E	NM_181719	NP_859070	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	13						integral to membrane					0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)		AGAGGCTGCTGAGGCAGCCTC	0.498000													7	29					0	0	0	0
TMEM57	55219	broad.mit.edu	37	1	25810760	25810760	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:25810760G>A	uc001bkk.2	+	7	1510	c.1308G>A	c.(1306-1308)CAG>CAA	p.Q436Q	TMEM57_uc009vru.2_Silent_p.Q209Q|TMEM57_uc009vrv.2_Silent_p.Q78Q	NM_018202	NP_060672	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	436						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part					0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)		AGCTGCTGCAGAACAAGTACG	0.572000													15	40					0	0	0	0
AHDC1	27245	broad.mit.edu	37	1	27875878	27875878	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:27875878C>T	uc009vsy.2	-	6	3718	c.2749G>A	c.(2749-2751)GCG>ACG	p.A917T	AHDC1_uc009vsz.1_Missense_Mutation_p.A917T	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	917							DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GTCTGGCGCGCGGACAGGACA	0.697000													16	43					0	0	0	0
MACF1	23499	broad.mit.edu	37	1	39749116	39749116	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:39749116A>G	uc010ois.1	+	10	1064	c.859A>G	c.(859-861)ATC>GTC	p.I287V	MACF1_uc001cda.1_Missense_Mutation_p.I195V	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	287	Actin-binding.|CH 2.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AAAGTCTGTAATCACTTATGT	0.418000													13	37					0	0	0	0
PABPC4	8761	broad.mit.edu	37	1	40027815	40027815	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:40027815C>T	uc010oiv.1	-	14	2673	c.1775G>A	c.(1774-1776)GGA>GAA	p.G592E	PPIEL_uc001cdk.2_5'Flank|PABPC4_uc001cdl.2_Missense_Mutation_p.G608E|PABPC4_uc001cdm.2_Missense_Mutation_p.G579E	NM_003819	NP_003810	Q13310	PABP4_HUMAN	poly A binding protein, cytoplasmic 4 isoform 2	592	PABC.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CAGCAGCATTCCCGTGATCTT	0.498000													7	28					0	0	0	0
LEPR	3953	broad.mit.edu	37	1	66101929	66101929	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:66101929C>A	uc001dci.2	+	20	2931	c.2729C>A	c.(2728-2730)CCT>CAT	p.P910H	LEPR_uc009waq.2_3'UTR	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	910	Cytoplasmic (Potential).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		ACATGTGGTCCTCTTCTTTTG	0.348000													39	96					7.63091e-17	1.48366e-16	1	0
ZNF326	284695	broad.mit.edu	37	1	90459386	90459386	+	5'Flank	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:90459386C>T	uc001dnq.2	+						GEMIN8P4_uc001dno.2_RNA|ZNF326_uc001dnp.3_5'Flank|ZNF326_uc009wda.1_5'Flank|ZNF326_uc001dnr.2_5'Flank	NM_182976	NP_892021	Q5BKZ1	ZN326_HUMAN	zinc finger protein 326 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	DNA binding			ovary(1)	1		all_lung(203;0.0116)|Lung NSC(277;0.0417)		all cancers(265;0.00728)|Epithelial(280;0.0265)		TCAGGCGCTCCGCATCCAGCT	0.602000													22	38					0	0	0	0
CHI3L2	1117	broad.mit.edu	37	1	111777615	111777615	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:111777615G>C	uc001eam.2	+	5	487	c.416G>C	c.(415-417)GGA>GCA	p.G139A	CHI3L2_uc001ean.2_Missense_Mutation_p.G129A|CHI3L2_uc001eao.2_Missense_Mutation_p.G60A|CHI3L2_uc009wga.2_Missense_Mutation_p.G60A	NM_004000	NP_003991	Q15782	CH3L2_HUMAN	chitinase 3-like 2 isoform a	139					chitin catabolic process	extracellular space	cation binding|chitinase activity			central_nervous_system(1)	1		all_cancers(81;1.89e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0171)|Colorectal(144;0.0387)|all cancers(265;0.0464)|LUSC - Lung squamous cell carcinoma(189;0.0872)|Epithelial(280;0.0994)|COAD - Colon adenocarcinoma(174;0.141)		AACTTTGATGGACTGGATGTA	0.398000													4	43					0	0	0	0
PSMD4	5710	broad.mit.edu	37	1	151237665	151237665	+	Silent	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:151237665C>G	uc001exl.2	+	5	455	c.393C>G	c.(391-393)CTC>CTG	p.L131L	PSMD4_uc001exn.2_Silent_p.L131L	NM_002810	NP_002801	P55036	PSMD4_HUMAN	proteasome 26S non-ATPase subunit 4	131	VWFA.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding|zinc ion binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CTAAACGCCTCAAGAAGGAGA	0.443000													3	47					0	0	0	0
FLG2	388698	broad.mit.edu	37	1	152327481	152327481	+	Silent	SNP	A	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:152327481A>G	uc001ezw.3	-	3	2854	c.2781T>C	c.(2779-2781)TCT>TCC	p.S927S	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	927	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACTTGAGCCAGAACCATGTT	0.488000													498	306					0	0	0	0
ILF2	3608	broad.mit.edu	37	1	153636573	153636573	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:153636573C>G	uc001fcr.2	-	10	771	c.690G>C	c.(688-690)TTG>TTC	p.L230F	ILF2_uc010pdy.1_Missense_Mutation_p.L192F|ILF2_uc009wok.2_Missense_Mutation_p.L208F	NM_004515	NP_004506	Q12905	ILF2_HUMAN	interleukin enhancer binding factor 2	230	DZF.				immune response|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|ribonucleoprotein complex	ATP binding|DNA binding|double-stranded RNA binding|protein binding|transferase activity				0	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			AACGAATCCTCAAGTCCTTCA	0.398000													6	33					0	0	0	0
IL6R	3570	broad.mit.edu	37	1	154437818	154437818	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:154437818T>G	uc001fez.1	+	10	1806	c.1369T>G	c.(1369-1371)TAT>GAT	p.Y457D	IL6R_uc001ffa.1_3'UTR	NM_000565	NP_000556	P08887	IL6RA_HUMAN	interleukin 6 receptor isoform 1 precursor	457	Cytoplasmic (Potential).				acute-phase response|ciliary neurotrophic factor-mediated signaling pathway|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|endocrine pancreas development|hepatic immune response|negative regulation of collagen biosynthetic process|negative regulation of interleukin-8 production|positive regulation of activation of Janus kinase activity|positive regulation of anti-apoptosis|positive regulation of chemokine production|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of leukocyte chemotaxis|positive regulation of MAPKKK cascade|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of apoptosis	apical plasma membrane|basolateral plasma membrane|extracellular space|interleukin-6 receptor complex	ciliary neurotrophic factor binding|enzyme binding|protein homodimerization activity			ovary(3)|breast(1)	4	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			ACGGAGCCCTTATGACATCAG	0.577000													7	128					0	0	0	0
SPTA1	6708	broad.mit.edu	37	1	158641861	158641861	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:158641861C>G	uc001fst.1	-	11	1675	c.1476G>C	c.(1474-1476)ATG>ATC	p.M492I		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	492	Spectrin 6.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CTTGTCTACTCATCCAACTGT	0.498000													27	116					0	0	0	0
FCRLA	84824	broad.mit.edu	37	1	161681748	161681748	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:161681748G>C	uc001gbe.2	+	5	835	c.593G>C	c.(592-594)AGA>ACA	p.R198T	FCRLA_uc001gbd.2_Missense_Mutation_p.R192T|FCRLA_uc001gbf.2_Missense_Mutation_p.R103T|FCRLA_uc001gbg.2_Missense_Mutation_p.R52T|FCRLA_uc009wuo.2_Missense_Mutation_p.R58T|FCRLA_uc009wup.2_Intron|FCRLA_uc009wuq.2_Intron	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	175	Ig-like C2-type 2.				cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			CCAATTCTCAGAGCTGTACCC	0.527000													5	443					0	0	0	0
C1orf114	57821	broad.mit.edu	37	1	169391472	169391472	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:169391472G>C	uc001gga.1	-	3	365	c.197C>G	c.(196-198)TCT>TGT	p.S66C	C1orf114_uc001gfz.1_Missense_Mutation_p.S66C|C1orf114_uc009wvq.1_Missense_Mutation_p.S66C|C1orf114_uc001ggb.2_Missense_Mutation_p.S66C|C1orf114_uc001ggc.1_Missense_Mutation_p.S66C	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	66											0	all_hematologic(923;0.208)					GTCAGGATCAGAATGCCGTTT	0.378000													8	84					0	0	0	0
TDRD5	163589	broad.mit.edu	37	1	179562647	179562647	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:179562647G>A	uc001gnf.1	+	3	535	c.285G>A	c.(283-285)AGG>AGA	p.R95R	TDRD5_uc010pnp.1_Silent_p.R95R	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	95	Lotus/OST-HTH 1.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						CAAAACAGAGGAGCAGCCATA	0.438000													15	43					0	0	0	0
TPR	7175	broad.mit.edu	37	1	186312565	186312565	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:186312565C>T	uc001grv.2	-	27	3940	c.3643G>A	c.(3643-3645)GAG>AAG	p.E1215K		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	1215	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TGAGCCACCTCAAACCTAGTT	0.353000			T	NTRK1	papillary thyroid								20	99					0	0	0	0
CFHR2	3080	broad.mit.edu	37	1	196920100	196920100	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:196920100G>A	uc001gtq.1	+	3	449	c.372G>A	c.(370-372)GAG>GAA	p.E124E	CFHR2_uc001gtr.1_Intron	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	124	Sushi 2.					extracellular region				skin(2)|ovary(1)	3						AAAACAATGAGAACAACATTT	0.393000													13	120					0	0	0	0
CRB1	23418	broad.mit.edu	37	1	197298069	197298069	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:197298069G>A	uc001gtz.2	+	2	723	c.588G>A	c.(586-588)AAG>AAA	p.K196K	CRB1_uc010poz.1_Silent_p.K127K|CRB1_uc001gty.1_Silent_p.K196K|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Silent_p.K196K|CRB1_uc010ppb.1_Silent_p.K196K	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	196	Extracellular (Potential).|EGF-like 5; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						ATCCCTGCAAGAACGAGGCTA	0.448000													4	68					0	0	0	0
KLHL12	59349	broad.mit.edu	37	1	202863774	202863774	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:202863774C>G	uc001gyo.1	-	9	1439	c.1239G>C	c.(1237-1239)CAG>CAC	p.Q413H	KLHL12_uc001gym.1_Missense_Mutation_p.Q146H|KLHL12_uc001gyn.1_Missense_Mutation_p.Q263H|KLHL12_uc010pqc.1_Missense_Mutation_p.Q451H|KLHL12_uc009xah.1_Missense_Mutation_p.Q312H	NM_021633	NP_067646	Q53G59	KLH12_HUMAN	kelch-like 12	413	Kelch 3.|Interaction with DVL3.				Wnt receptor signaling pathway		protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.166)			CCCGGGCTGTCTGCATATCTC	0.527000													28	262					0	0	0	0
CHIT1	1118	broad.mit.edu	37	1	203186208	203186208	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:203186208G>A	uc001gzn.2	-	11	1306	c.1210C>T	c.(1210-1212)CAG>TAG	p.Q404*	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_Intron|CHIT1_uc009xal.1_Nonsense_Mutation_p.Q166*|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Nonsense_Mutation_p.Q395*	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	404					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						TCAGAGGGCTGACCTGGTTTT	0.567000											OREG0014113	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	122					0	0	0	0
FMOD	2331	broad.mit.edu	37	1	203316510	203316510	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:203316510C>T	uc001gzr.2	-	2	1025	c.889G>A	c.(889-891)GAG>AAG	p.E297K	FMOD_uc010pqi.1_RNA	NM_002023	NP_002014	Q06828	FMOD_HUMAN	fibromodulin precursor	297	LRR 9.				transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				ovary(2)|breast(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.171)			AGGTCTAGCTCAAGGAGGCTG	0.557000													114	105					0	0	0	0
REN	5972	broad.mit.edu	37	1	204128555	204128555	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:204128555C>G	uc001haq.2	-	5	705	c.661G>C	c.(661-663)GAG>CAG	p.E221Q		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	221					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	AAGACGTCCTCTTTTAGCACC	0.562000													18	104					0	0	0	0
SLC41A1	254428	broad.mit.edu	37	1	205779410	205779410	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:205779410G>A	uc001hdh.1	-	2	1032	c.160C>T	c.(160-162)CGG>TGG	p.R54W		NM_173854	NP_776253	Q8IVJ1	S41A1_HUMAN	solute carrier family 41 member 1	54						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			skin(2)	2	Breast(84;0.0799)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			GCGTTGGCCCGAGACTCAATC	0.652000											OREG0014163	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	99					0	0	0	0
CR1	1378	broad.mit.edu	37	1	207741206	207741206	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:207741206G>A	uc001hfy.2	+	17	2780	c.2640G>A	c.(2638-2640)GGG>GGA	p.G880G	CR1_uc009xcl.1_Silent_p.G430G|CR1_uc001hfx.2_Silent_p.G1330G|CR1_uc009xck.1_Silent_p.G430G	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	880	Extracellular (Potential).|Sushi 14.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						TTCCTAATGGGAGACACACAG	0.433000													10	367					0	0	0	0
LIN9	286826	broad.mit.edu	37	1	226474137	226474137	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:226474137C>G	uc001hqa.2	-	6	779	c.469G>C	c.(469-471)GAC>CAC	p.D157H	LIN9_uc001hqb.2_Missense_Mutation_p.D122H|LIN9_uc001hqc.2_Missense_Mutation_p.D89H|LIN9_uc009xel.1_Missense_Mutation_p.D122H	NM_173083	NP_775106	Q5TKA1	LIN9_HUMAN	lin-9 homolog	141	Sufficient for interaction with RB1.				cell cycle|DNA replication	nucleoplasm					0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		ACACAGAAGTCATTATCACCT	0.318000													24	63					0	0	0	0
OBSCN	84033	broad.mit.edu	37	1	228432256	228432256	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:228432256C>T	uc009xez.1	+	11	3509	c.3465C>T	c.(3463-3465)TTC>TTT	p.F1155F	OBSCN_uc001hsn.2_Silent_p.F1155F	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1155	Ig-like 11.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GAGTCTCCTTCCACCTGCACA	0.542000													11	196					0	0	0	0
OBSCN	84033	broad.mit.edu	37	1	228521393	228521393	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:228521393C>T	uc009xez.1	+	59	16010	c.15966C>T	c.(15964-15966)TCC>TCT	p.S5322S	OBSCN_uc001hsn.2_Silent_p.S5322S|OBSCN_uc001hsr.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	5322	Ig-like 50.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				AGATCATCTCCGTCACCCGGG	0.582000													9	8					0	0	0	0
OBSCN	84033	broad.mit.edu	37	1	228556503	228556503	+	Silent	SNP	A	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:228556503A>G	uc009xez.1	+	89	19892	c.19848A>G	c.(19846-19848)CCA>CCG	p.P6616P	OBSCN_uc001hsr.1_Silent_p.P1245P	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6616	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				ACATCACCCCAGCAGAGCTGC	0.567000													158	98					0	0	0	0
TRIM67	440730	broad.mit.edu	37	1	231335933	231335933	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:231335933C>T	uc009xfn.1	+	4	1345	c.1303C>T	c.(1303-1305)CGT>TGT	p.R435C		NM_001004342	NP_001004342	Q6ZTA4	TRI67_HUMAN	tripartite motif-containing 67	435						cytoplasm|cytoskeleton	zinc ion binding			ovary(2)|breast(1)|kidney(1)	4	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				ATTGAAGCTGCGTCAGTCCAC	0.532000													14	219					0	0	0	0
FMN2	56776	broad.mit.edu	37	1	240371390	240371390	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:240371390G>A	uc010pyd.1	+	5	3503	c.3278G>A	c.(3277-3279)GGA>GAA	p.G1093E	FMN2_uc010pye.1_Missense_Mutation_p.G1097E	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1093	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCTCTACCCGGAGCGGGCATA	0.726000													3	9					0	0	0	0
OR2L3	391192	broad.mit.edu	37	1	248224496	248224496	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:248224496G>T	uc001idx.1	+	1	513	c.513G>T	c.(511-513)AGG>AGT	p.R171S	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GCCAATCCAGGGCCATCAATC	0.473000													32	219					1.74807e-11	3.32663e-11	1	0
LYZL1	84569	broad.mit.edu	37	10	29599073	29599073	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr10:29599073C>T	uc001iul.2	+	4	528	c.471C>T	c.(469-471)ATC>ATT	p.I157I		NM_032517	NP_115906	Q6UWQ5	LYZL1_HUMAN	lysozyme-like 1	111					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0		Breast(68;0.203)				ATGCAATTATCTGTGCCAGGA	0.433000													12	30					0	0	0	0
ANK3	288	broad.mit.edu	37	10	62149197	62149197	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr10:62149197C>T	uc001jky.2	-	1	292	c.100G>A	c.(100-102)GAT>AAT	p.D34N	ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jlb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	34					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TTCTTCCGATCCCGGGACCGT	0.408000													15	60					0	0	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72500862	72500862	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr10:72500862C>T	uc001jrh.2	+	12	1868	c.1868C>T	c.(1867-1869)TCC>TTC	p.S623F	ADAMTS14_uc001jrg.2_Missense_Mutation_p.S626F|ADAMTS14_uc001jri.1_Missense_Mutation_p.S146F	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	623	Cys-rich.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						AAGCGCAACTCCTACTATGTG	0.617000													13	33					0	0	0	0
C10orf58	84293	broad.mit.edu	37	10	82187156	82187156	+	Nonsense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr10:82187156C>G	uc001kcc.3	+	5	640	c.480C>G	c.(478-480)TAC>TAG	p.Y160*	C10orf58_uc001kcd.3_Nonsense_Mutation_p.Y149*|C10orf58_uc001kce.3_Nonsense_Mutation_p.Y160*|C10orf58_uc001kcf.3_Nonsense_Mutation_p.Y160*	NM_032333	NP_115709	Q9BRX8	CJ058_HUMAN	hypothetical protein LOC84293 precursor	160						extracellular region					0			Colorectal(32;0.229)			GAGTGTGGTACAACTTCTTCC	0.488000													4	61					0	0	0	0
PLCE1	51196	broad.mit.edu	37	10	95892130	95892130	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr10:95892130C>T	uc001kjk.2	+	3	2040	c.1406C>T	c.(1405-1407)TCT>TTT	p.S469F	PLCE1_uc010qnx.1_Missense_Mutation_p.S469F|PLCE1_uc001kjm.2_Missense_Mutation_p.S161F	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	469					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				ATCACCGGTTCTCTCCTAGAA	0.478000													7	94					0	0	0	0
ENTPD7	57089	broad.mit.edu	37	10	101451214	101451214	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr10:101451214G>A	uc001kqa.3	+	8	960	c.782G>A	c.(781-783)GGA>GAA	p.G261E	ENTPD7_uc009xwl.2_Missense_Mutation_p.G263E	NM_020354	NP_065087	Q9NQZ7	ENTP7_HUMAN	ectonucleoside triphosphate diphosphohydrolase	261	Vesicular (Potential).					cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)		GATATGGGAGGAGCCTCTCTC	0.453000													7	37					0	0	0	0
PNLIPRP2	5408	broad.mit.edu	37	10	118394400	118394400	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr10:118394400A>T	uc001lcq.2	+	11	892	c.869A>T	c.(868-870)TAC>TTC	p.Y290F	PNLIPRP2_uc009xyu.1_RNA|PNLIPRP2_uc009xyv.1_RNA	NM_005396	NP_005387	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2	289					galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)		TTCGAGTATTACTCAAGCAGC	0.498000													7	34					0	0	0	0
PHRF1	57661	broad.mit.edu	37	11	587346	587346	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr11:587346C>G	uc001lqe.2	+	4	433	c.302C>G	c.(301-303)TCT>TGT	p.S101C	PHRF1_uc010qwc.1_Missense_Mutation_p.S101C|PHRF1_uc010qwd.1_Missense_Mutation_p.S100C|PHRF1_uc010qwe.1_Missense_Mutation_p.S97C	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	101							RNA polymerase binding|zinc ion binding				0						TCTTTCAATTCTGATGATGAT	0.562000													17	31					0	0	0	0
MUC5B	727897	broad.mit.edu	37	11	1157901	1157901	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr11:1157901G>A	uc009ycr.1	+	9	1094	c.968G>A	c.(967-969)GGG>GAG	p.G323E		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	314					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CATGCAGGGGGGTTGCCCCAG	0.667000													10	31					0	0	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137497	40137497	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr11:40137497C>T	uc001mxa.1	-	2	2310	c.346G>A	c.(346-348)GAA>AAA	p.E116K	LRRC4C_uc001mxc.1_Missense_Mutation_p.E112K|LRRC4C_uc001mxd.1_Missense_Mutation_p.E112K|LRRC4C_uc001mxb.1_Missense_Mutation_p.E112K	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	116	LRR 2.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GCCCCAATTTCAATGGTTCTG	0.428000													11	58					0	0	0	0
OR5AR1	219493	broad.mit.edu	37	11	56431302	56431302	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr11:56431302C>G	uc010rjm.1	+	1	141	c.141C>G	c.(139-141)ATC>ATG	p.I47M		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	47	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTATGATTATCCTGATTACAA	0.473000													10	183					0	0	0	0
NRXN2	9379	broad.mit.edu	37	11	64428240	64428240	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr11:64428240G>A	uc001oar.2	-	11	2609	c.2170C>T	c.(2170-2172)CGG>TGG	p.R724W	NRXN2_uc001oas.2_Missense_Mutation_p.R693W|NRXN2_uc001oaq.2_Missense_Mutation_p.R391W	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:Variant_position_missing_in_P58401_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						TCACAGACCCGCCCAAGAAAG	0.592000													17	45					0	0	0	0
RELT	84957	broad.mit.edu	37	11	73106303	73106303	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr11:73106303G>A	uc001otv.2	+	10	1383	c.1218G>A	c.(1216-1218)CTG>CTA	p.L406L	RELT_uc001otw.2_Silent_p.L406L|RELT_uc001otx.2_RNA	NM_152222	NP_689408	Q969Z4	TR19L_HUMAN	RELT tumor necrosis factor receptor precursor	406	Cytoplasmic (Potential).					cytoplasm|integral to membrane|plasma membrane	binding|receptor activity			upper_aerodigestive_tract(1)	1						CAAAGTGGCTGAAGCCCCCAG	0.642000													5	105					0	0	0	0
SLC36A4	120103	broad.mit.edu	37	11	92918982	92918982	+	Splice_Site	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr11:92918982T>A	uc001pdn.2	-	2	153	c.56_splice	c.e2-1	p.D19_splice	SLC36A4_uc001pdm.2_Splice_Site	NM_152313	NP_689526	Q6YBV0	S36A4_HUMAN	solute carrier family 36 (proton/amino acid						L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CATCCATATCTTTAAAAAAGA	0.333000													9	13					0	0	0	0
IL10RA	3587	broad.mit.edu	37	11	117864051	117864051	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr11:117864051G>T	uc001prv.2	+	4	540	c.463G>T	c.(463-465)GAC>TAC	p.D155Y	IL10RA_uc010rxl.1_Missense_Mutation_p.D135Y|IL10RA_uc010rxm.1_Missense_Mutation_p.D135Y|IL10RA_uc010rxn.1_Missense_Mutation_p.D6Y|IL10RA_uc001prw.2_Missense_Mutation_p.D6Y	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor	155	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		CCCCGCAAATGACACATATGA	0.527000													4	38					0.00024832	0.000455979	1	0
YARS2	51067	broad.mit.edu	37	12	32908286	32908286	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr12:32908286C>A	uc001rli.2	-	1	589	c.523G>T	c.(523-525)GCC>TCC	p.A175S		NM_001040436	NP_001035526	Q9Y2Z4	SYYM_HUMAN	tyrosyl-tRNA synthetase 2, mitochondrial	175					tyrosyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|RNA binding|tyrosine-tRNA ligase activity				0	Lung NSC(5;2.43e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)				L-Tyrosine(DB00135)	TGGTACCAGGCCGAGTTGTCC	0.657000											OREG0021729	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	22					0.000566183	0.00103361	1	0
DDN	23109	broad.mit.edu	37	12	49392252	49392252	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr12:49392252C>G	uc001rsv.1	-	2	425	c.407G>C	c.(406-408)CGA>CCA	p.R136P	uc001rsw.2_5'UTR	NM_015086	NP_055901	O94850	DEND_HUMAN	dendrin	136						dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				large_intestine(1)	1						GGGGCTCCGTCGGGCCCCACC	0.741000													6	13					0	0	0	0
SLC4A8	9498	broad.mit.edu	37	12	51851325	51851325	+	Splice_Site	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr12:51851325T>C	uc001rys.1	+	6	941	c.763_splice	c.e6+2	p.G255_splice	SLC4A8_uc010sni.1_Splice_Site_p.G202_splice|SLC4A8_uc001rym.2_Splice_Site_p.G202_splice|SLC4A8_uc001ryn.2_Splice_Site_p.G202_splice|SLC4A8_uc001ryo.2_Splice_Site_p.G202_splice|SLC4A8_uc001ryp.1_Splice_Site_p.G202_splice|SLC4A8_uc010snj.1_Splice_Site_p.G282_splice|SLC4A8_uc001ryq.3_Splice_Site_p.G255_splice|SLC4A8_uc001ryr.2_Splice_Site_p.G255_splice|SLC4A8_uc010snk.1_Splice_Site_p.G202_splice	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate						bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		ATAAACATGGTAAGATTATTA	0.388000													17	33					0	0	0	0
SCN8A	6334	broad.mit.edu	37	12	52201213	52201213	+	Nonstop_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr12:52201213G>C	uc001ryw.2	+	27	6121	c.5943G>C	c.(5941-5943)TAG>TAC	p.*1981Y	uc001rzb.1_5'Flank	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1981					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CCAAGTGTTAGAGGAGAACAA	0.393000													2	4					0	0	0	0
SYT1	6857	broad.mit.edu	37	12	79689943	79689943	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr12:79689943A>T	uc001sys.2	+	8	1240	c.569A>T	c.(568-570)AAG>ATG	p.K190M	SYT1_uc001syt.2_Missense_Mutation_p.K190M|SYT1_uc001syu.2_Missense_Mutation_p.K187M|SYT1_uc001syv.2_Missense_Mutation_p.K190M	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	190	Cytoplasmic (Potential).|Phospholipid binding (Probable).|C2 1.				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						CTACCTGATAAGAAGAAGAAA	0.418000													20	42					0	0	0	0
PAWR	5074	broad.mit.edu	37	12	79988212	79988212	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr12:79988212T>A	uc001syx.2	-	6	1119	c.833A>T	c.(832-834)GAA>GTA	p.E278V		NM_002583	NP_002574	Q96IZ0	PAWR_HUMAN	PRKC, apoptosis, WT1, regulator	278					actin filament bundle assembly|apoptosis|induction of apoptosis|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	actin binding|enzyme binding|leucine zipper domain binding|transcription corepressor activity				0						TCTTACTACTTCCTGGTAGAT	0.294000													8	16					0	0	0	0
ACSS3	79611	broad.mit.edu	37	12	81503457	81503457	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr12:81503457T>A	uc001szl.1	+	2	521	c.430T>A	c.(430-432)TTT>ATT	p.F144I	ACSS3_uc001szm.1_Missense_Mutation_p.F143I	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	144						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						TAAAGCAACCTTTACCTATAA	0.299000													7	25					0	0	0	0
EEA1	8411	broad.mit.edu	37	12	93213152	93213152	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr12:93213152G>C	uc001tck.2	-	14	1925	c.1660C>G	c.(1660-1662)CAG>GAG	p.Q554E		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	554	Gln/Glu/Lys-rich.|Potential.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						TCACCAGCCTGAATTTTTGCA	0.313000													6	30					0	0	0	0
ANO4	121601	broad.mit.edu	37	12	101510564	101510564	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr12:101510564T>C	uc010svm.1	+	25	3130	c.2558T>C	c.(2557-2559)CTT>CCT	p.L853P	ANO4_uc001thw.2_Missense_Mutation_p.L818P|ANO4_uc001thx.2_Missense_Mutation_p.L853P|ANO4_uc001thy.2_Missense_Mutation_p.L373P	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	853	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						GGGACTCCTCTTAAGTACTGC	0.542000										HNSCC(74;0.22)			4	81					0	0	0	0
UTP20	27340	broad.mit.edu	37	12	101779782	101779782	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr12:101779782A>G	uc001tia.1	+	62	8395	c.8239A>G	c.(8239-8241)ATG>GTG	p.M2747V		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	2747	Nuclear localization signal.|Potential.|Nucleolar localization signal.				endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						CAAGAAAAAAATGAAGAAACA	0.308000													23	51					0	0	0	0
MYBPC1	4604	broad.mit.edu	37	12	102036248	102036248	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr12:102036248G>A	uc001tii.2	+	9	744	c.642G>A	c.(640-642)CTG>CTA	p.L214L	MYBPC1_uc001tif.1_Silent_p.L227L|MYBPC1_uc001tig.2_Silent_p.L239L|MYBPC1_uc010svq.1_Silent_p.L201L|MYBPC1_uc001tih.2_Silent_p.L239L|MYBPC1_uc001tij.2_Silent_p.L214L|MYBPC1_uc010svr.1_Silent_p.L214L|MYBPC1_uc010svs.1_Silent_p.L214L|MYBPC1_uc010svt.1_Silent_p.L202L|MYBPC1_uc010svu.1_Silent_p.L195L|MYBPC1_uc001tik.2_Silent_p.L188L	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	214					cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						GGGAGTTGCTGAAGAACGCGA	0.562000													15	43					0	0	0	0
ATP2A2	488	broad.mit.edu	37	12	110764234	110764234	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr12:110764234C>T	uc001tqk.3	+	7	1147	c.584C>T	c.(583-585)CCT>CTT	p.P195L	ATP2A2_uc001tql.3_Missense_Mutation_p.P195L|ATP2A2_uc010sxy.1_Missense_Mutation_p.P168L	NM_170665	NP_733765	P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, slow twitch 2 isoform	195	Cytoplasmic (By similarity).				ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			ovary(3)|skin(1)	4						GATCCCGTCCCTGACCCACGA	0.423000													4	25					0	0	0	0
SBNO1	55206	broad.mit.edu	37	12	123780467	123780467	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr12:123780467C>G	uc010tap.1	-	31	4170	c.4170G>C	c.(4168-4170)TTG>TTC	p.L1390F	SBNO1_uc009zxv.2_RNA|SBNO1_uc010tao.1_Missense_Mutation_p.L1389F|SBNO1_uc010taq.1_Missense_Mutation_p.L341F	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1390							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		ATGCGTTGCTCAAGTTGGTGA	0.428000													8	257					0	0	0	0
GJB2	2706	broad.mit.edu	37	13	20763385	20763385	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr13:20763385C>T	uc001umy.2	-	2	551	c.336G>A	c.(334-336)AAG>AAA	p.K112K		NM_004004	NP_003995	P29033	CXB2_HUMAN	gap junction protein beta 2	112	Cytoplasmic (Potential).			K -> N (in Ref. 4; AAY25170).	cell-cell signaling|cellular membrane organization|gap junction assembly|sensory perception of sound|transport	connexon complex|ER-Golgi intermediate compartment|integral to membrane					0		all_cancers(29;3.95e-22)|all_epithelial(30;2.36e-19)|all_lung(29;2.27e-18)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;0.000435)|Epithelial(112;0.000722)|OV - Ovarian serous cystadenocarcinoma(117;0.0096)|Lung(94;0.0236)|LUSC - Lung squamous cell carcinoma(192;0.0738)		TAAATTCACTCTTTATCTCCC	0.532000									Keratitis_Ichthyosis_and_Deafness_syndrome		OREG0022282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	57					0	0	0	0
FRY	10129	broad.mit.edu	37	13	32869543	32869543	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr13:32869543C>A	uc001utx.2	+	61	9484	c.8988C>A	c.(8986-8988)TAC>TAA	p.Y2996*	FRY_uc010tdw.1_RNA|FRY_uc001utz.2_Nonsense_Mutation_p.Y527*|FRY_uc010tdx.1_Nonsense_Mutation_p.Y366*	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2996					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CCCAGAGTTACCGAGTCCTCA	0.567000													20	46					1.2644e-06	2.35622e-06	1	0
BRCA2	675	broad.mit.edu	37	13	32950881	32950881	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr13:32950881G>A	uc001uub.1	+	21	8934	c.8707G>A	c.(8707-8709)GAG>AAG	p.E2903K		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2903					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AGATGGTGCAGAGCTTTATGA	0.388000			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			5	26					0	0	0	0
TDRD3	81550	broad.mit.edu	37	13	61068665	61068665	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr13:61068665T>G	uc001via.2	+	8	1323	c.535T>G	c.(535-537)TCA>GCA	p.S179A	TDRD3_uc010aef.2_5'UTR|TDRD3_uc001vhz.3_Missense_Mutation_p.S179A|TDRD3_uc010aeg.2_Missense_Mutation_p.S272A|TDRD3_uc001vib.3_Missense_Mutation_p.S178A	NM_030794	NP_110421	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3 isoform 2	179					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			upper_aerodigestive_tract(1)|skin(1)	2		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		GAAAGAAAAGTCAACCAAATC	0.363000													6	36					0	0	0	0
DACH1	1602	broad.mit.edu	37	13	72063278	72063278	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr13:72063278C>T	uc010thn.1	-	8	1996	c.1573G>A	c.(1573-1575)GAG>AAG	p.E525K	DACH1_uc010tho.1_Missense_Mutation_p.E377K|DACH1_uc010thp.1_Missense_Mutation_p.E323K	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	577					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		AGCGGGGTCTCATCTGCATGT	0.428000													26	109					0	0	0	0
TBC1D4	9882	broad.mit.edu	37	13	75873593	75873593	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr13:75873593C>A	uc001vjl.1	-	17	3376	c.3029G>T	c.(3028-3030)GGG>GTG	p.G1010V	TBC1D4_uc010tht.1_Missense_Mutation_p.G220V|TBC1D4_uc010thu.1_Missense_Mutation_p.G167V|TBC1D4_uc010aer.2_Missense_Mutation_p.G1002V|TBC1D4_uc010aes.2_Missense_Mutation_p.G947V	NM_014832	NP_055647	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	1010	Rab-GAP TBC.					cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		AAAGCTGATCCCCTGACAGTA	0.493000													19	30					5.35356e-11	1.01266e-10	1	0
NALCN	259232	broad.mit.edu	37	13	101890129	101890129	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr13:101890129G>A	uc001vox.1	-	12	1600	c.1411C>T	c.(1411-1413)CAT>TAT	p.H471Y	NALCN_uc001voy.2_Missense_Mutation_p.H186Y|NALCN_uc001voz.2_Missense_Mutation_p.H471Y|NALCN_uc001vpa.2_Missense_Mutation_p.H471Y	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	471	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AATTGTGAATGATAAAGATCT	0.308000													39	130					0	0	0	0
TUBGCP3	10426	broad.mit.edu	37	13	113223541	113223541	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr13:113223541G>A	uc001vse.1	-	2	296	c.109C>T	c.(109-111)CGG>TGG	p.R37W	TUBGCP3_uc010tjq.1_Missense_Mutation_p.R37W|TUBGCP3_uc001vsf.2_Missense_Mutation_p.R37W|TUBGCP3_uc001vsg.1_Missense_Mutation_p.R37W	NM_006322	NP_006313	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	37					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					CCAATCACCCGCACAGCATAC	0.433000													15	42					0	0	0	0
OR4Q3	441669	broad.mit.edu	37	14	20216405	20216405	+	Silent	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr14:20216405C>A	uc010tkt.1	+	1	819	c.819C>A	c.(817-819)TCC>TCA	p.S273S		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	273	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGATATTCTCCTTGTTTTACA	0.433000													20	157					7.41877e-09	1.39491e-08	1	0
MYH7	4625	broad.mit.edu	37	14	23884302	23884302	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr14:23884302C>G	uc001wjx.2	-	37	5567	c.5461G>C	c.(5461-5463)GAG>CAG	p.E1821Q		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1821	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TTCTCCAGCTCCCGCACCCGC	0.627000													16	109					0	0	0	0
KIAA0391	9692	broad.mit.edu	37	14	35593231	35593231	+	Silent	SNP	A	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr14:35593231A>C	uc001wsy.1	+	2	1140	c.780A>C	c.(778-780)GTA>GTC	p.V260V	KIAA0391_uc010tps.1_Silent_p.V165V|KIAA0391_uc001wsz.1_Silent_p.V260V|KIAA0391_uc001wta.2_RNA|KIAA0391_uc001wtb.1_Silent_p.V260V|KIAA0391_uc001wtc.1_Intron|PPP2R3C_uc001wss.2_5'Flank|PPP2R3C_uc001wst.2_5'Flank|PPP2R3C_uc010tpr.1_5'Flank|PPP2R3C_uc001wsu.2_5'Flank|PPP2R3C_uc010amn.1_5'Flank|PPP2R3C_uc001wsw.2_5'Flank|PPP2R3C_uc001wsx.1_5'Flank	NM_014672	NP_055487	O15091	MRRP3_HUMAN	mitochondrial RNase P protein 3 precursor	260					tRNA processing	mitochondrion					0	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;2.93e-05)|LUAD - Lung adenocarcinoma(48;3.86e-05)|Epithelial(34;0.0114)|all cancers(34;0.0277)	GBM - Glioblastoma multiforme(112;0.0593)		ATCAAGATGTAAACACAGCTT	0.343000													9	20					0	0	0	0
MDGA2	161357	broad.mit.edu	37	14	47504427	47504427	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr14:47504427C>G	uc001wwj.3	-	8	1595	c.1399G>C	c.(1399-1401)GTA>CTA	p.V467L	MDGA2_uc001wwi.3_Missense_Mutation_p.V238L|MDGA2_uc010ani.2_Missense_Mutation_p.V27L	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	467	Ig-like 5.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						TTGCCAGTTACTTGACATTGC	0.413000													32	75					0	0	0	0
KCNH5	27133	broad.mit.edu	37	14	63175134	63175134	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr14:63175134C>T	uc001xfx.2	-	11	2110	c.2059G>A	c.(2059-2061)GAG>AAG	p.E687K	KCNH5_uc001xfy.2_3'UTR	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	687	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		AGGCGCTCCTCCTCCTCTTTC	0.493000													16	68					0	0	0	0
EXD2	55218	broad.mit.edu	37	14	69701456	69701456	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr14:69701456C>T	uc001xkt.2	+	7	1041	c.382C>T	c.(382-384)CTC>TTC	p.L128F	EXD2_uc001xku.2_Intron|EXD2_uc001xkv.2_Missense_Mutation_p.L253F|EXD2_uc001xkw.2_Missense_Mutation_p.L128F|EXD2_uc010aqt.2_Missense_Mutation_p.L253F|EXD2_uc010tte.1_Missense_Mutation_p.L253F|EXD2_uc001xky.2_Missense_Mutation_p.L128F	NM_018199	NP_060669	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2	128					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding				0						TTCAGTGGCTCTCTTTCTTCA	0.433000													9	26					0	0	0	0
C14orf169	79697	broad.mit.edu	37	14	73959074	73959074	+	Silent	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr14:73959074G>C	uc001xok.1	+	3	1432	c.1353G>C	c.(1351-1353)CGG>CGC	p.R451R	HEATR4_uc010tua.1_Intron	NM_024644	NP_078920	Q9H6W3	NO66_HUMAN	chromosome 14 open reading frame 169	451					negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K4 specific)|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.215)		TGGAGTTTCGGAGGGGTCTGC	0.547000													13	45					0	0	0	0
SEL1L	6400	broad.mit.edu	37	14	81972553	81972553	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr14:81972553C>T	uc010tvv.1	-	4	490	c.373G>A	c.(373-375)GAG>AAG	p.E125K	SEL1L_uc001xvo.3_Missense_Mutation_p.E125K	NM_005065	NP_005056	Q9UBV2	SE1L1_HUMAN	sel-1 suppressor of lin-12-like precursor	125	Lumenal (Potential).|Interaction with ERLEC1, OS9 and SYVN1.|Fibronectin type-II.				Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0299)		TGGCAGGGCTCCCCATGTGCT	0.438000													12	39					0	0	0	0
SLC24A4	123041	broad.mit.edu	37	14	92959967	92959967	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr14:92959967G>A	uc001yak.2	+	17	1837	c.1813G>A	c.(1813-1815)GAT>AAT	p.D605N	SLC24A4_uc001yai.2_Missense_Mutation_p.D558N|SLC24A4_uc010twm.1_Missense_Mutation_p.D603N|SLC24A4_uc001yaj.2_Missense_Mutation_p.D586N|SLC24A4_uc010auj.2_3'UTR|SLC24A4_uc010twn.1_Missense_Mutation_p.D378N|SLC24A4_uc001yan.2_Missense_Mutation_p.D316N	NM_153646	NP_705932	Q8NFF2	NCKX4_HUMAN	solute carrier family 24 member 4 isoform 1	622	Extracellular (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(2)|ovary(1)	3		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		CCGGGAAGACGATTAGCGCTG	0.547000													4	20					0	0	0	0
FAM181A	90050	broad.mit.edu	37	14	94395169	94395169	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr14:94395169G>A	uc001ybz.1	+	3	1031	c.724G>A	c.(724-726)GAG>AAG	p.E242K	C14orf86_uc001yby.2_5'Flank|FAM181A_uc010aus.1_Missense_Mutation_p.E180K|FAM181A_uc001yca.1_Missense_Mutation_p.E180K	NM_138344	NP_612353	Q8N9Y4	F181A_HUMAN	hypothetical protein LOC90050	242											0						CCTGGGACCTGAGACTACCCT	0.622000													4	33					0	0	0	0
DDX24	57062	broad.mit.edu	37	14	94521392	94521392	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr14:94521392C>T	uc001ycj.2	-	7	2227	c.2128G>A	c.(2128-2130)GAG>AAG	p.E710K	DDX24_uc010twq.1_Missense_Mutation_p.E667K|DDX24_uc010twr.1_Missense_Mutation_p.E460K	NM_020414	NP_065147	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	710	Helicase C-terminal.				RNA metabolic process	cytoplasm|nucleolus|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|skin(1)	4		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		GGGATATCCTCATCTTTCTTG	0.463000													32	149					0	0	0	0
IFI27L1	122509	broad.mit.edu	37	14	94567115	94567115	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr14:94567115G>C	uc001ycl.2	+	3	267	c.59G>C	c.(58-60)GGA>GCA	p.G20A	IFI27L1_uc001yck.2_Missense_Mutation_p.G20A	NM_206949	NP_996832	Q96BM0	I27L1_HUMAN	interferon, alpha-inducible protein 27-like 1	20	Helical; (Potential).					integral to membrane					0						GTGGTCGGAGGAGGTGAGTCT	0.507000													14	62					0	0	0	0
ATG2B	55102	broad.mit.edu	37	14	96757161	96757161	+	Silent	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr14:96757161T>C	uc001yfi.2	-	39	6056	c.5691A>G	c.(5689-5691)CTA>CTG	p.L1897L		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	1897										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		CTAATTGTACTAGTGAATGCA	0.284000													26	66					0	0	0	0
AKT1	207	broad.mit.edu	37	14	105246455	105246455	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr14:105246455C>T	uc001ypk.2	-	3	699	c.145G>A	c.(145-147)GAG>AAG	p.E49K	INF2_uc010tyi.1_Intron|AKT1_uc001ypl.2_Missense_Mutation_p.E49K|AKT1_uc010axa.2_Missense_Mutation_p.E49K|AKT1_uc001ypm.2_Missense_Mutation_p.E49K|AKT1_uc001ypn.2_Missense_Mutation_p.E49K|AKT1_uc010tyk.1_5'Flank	NM_005163	NP_005154	P31749	AKT1_HUMAN	AKT1 kinase	49	PH.				activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity	p.E49K(1)		breast(86)|urinary_tract(12)|thyroid(10)|lung(7)|endometrium(5)|large_intestine(4)|skin(4)|prostate(3)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|NS(1)	134		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)	AGGGGAGCCTCACGTTGGTCC	0.587000		1	Mis		breast|colorectal|ovarian|NSCLC								11	13					0	0	0	0
ATP10A	57194	broad.mit.edu	37	15	25963462	25963462	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr15:25963462C>A	uc010ayu.2	-	8	1554	c.1448G>T	c.(1447-1449)AGC>ATC	p.S483I		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	483	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GCTGCCGATGCTGCCGCGCTG	0.711000													11	8					6.40141e-05	0.000117891	1	0
MYO5A	4644	broad.mit.edu	37	15	52656782	52656782	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr15:52656782T>A	uc002aby.2	-	24	3522	c.3278A>T	c.(3277-3279)GAT>GTT	p.D1093V	MYO5A_uc002abx.3_Missense_Mutation_p.D1093V	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	1093	Potential.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		CTTGAGGTCATCATATCTTTC	0.284000													25	54					0	0	0	0
TLN2	83660	broad.mit.edu	37	15	63128147	63128147	+	Missense_Mutation	SNP	C	G	G	rs140723056	by1000genomes	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr15:63128147C>G	uc002alb.3	+	54	7249	c.7249C>G	c.(7249-7251)CAG>GAG	p.Q2417E	TLN2_uc002alc.3_Missense_Mutation_p.Q810E|TLN2_uc010uic.1_Missense_Mutation_p.Q18E|uc002ale.1_5'Flank	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	2417	I/LWEQ.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						TGCCTCCGTTCAGGGACACGC	0.647000													5	37					0	0	0	0
CALML4	91860	broad.mit.edu	37	15	68489825	68489825	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr15:68489825A>T	uc002arb.2	-	4	1180	c.446T>A	c.(445-447)CTG>CAG	p.L149Q	CALML4_uc002arc.2_Missense_Mutation_p.L102Q|CALML4_uc002ard.2_RNA|CALML4_uc002are.2_RNA|CALML4_uc010bhz.2_Intron	NM_033429	NP_219501	Q96GE6	CALL4_HUMAN	calmodulin-like 4 isoform 1	149	EF-hand 3.						calcium ion binding				0						TTTTGACCGCAGGTCGGACGC	0.498000													21	71					0	0	0	0
ERCC4	2072	broad.mit.edu	37	16	14020442	14020442	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr16:14020442G>A	uc002dce.2	+	3	422	c.413G>A	c.(412-414)AGA>AAA	p.R138K	ERCC4_uc010bva.2_Missense_Mutation_p.R138K	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	138					double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10						AGAGCCCACAGAATAATCGAG	0.353000			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				6	98					0	0	0	0
Unknown	0	broad.mit.edu	37	16	32077573	32077573	+	RNA	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr16:32077573C>T	uc010vfu.1	+	1		c.15C>T								Homo sapiens mRNA for immunoglobulin heavy chain, VHDJH rearrangement : VHLI26.																		TACGCAGACTCTGTGAAAGGC	0.517000													70	226					0	0	0	0
C16orf46	123775	broad.mit.edu	37	16	81087678	81087678	+	Nonstop_Mutation	SNP	A	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr16:81087678A>G	uc010chf.2	-	4	1335	c.1165T>C	c.(1165-1167)TAG>CAG	p.*389Q		NM_001100873	NP_001094343	Q6P387	CP046_HUMAN	chromosome 16 open reading frame 46 isoform 1	389											0						TCCCTCTCCTACTTTATCTTC	0.408000													16	38					0	0	0	0
MBTPS1	8720	broad.mit.edu	37	16	84108251	84108251	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr16:84108251T>A	uc002fhi.2	-	12	2046	c.1544A>T	c.(1543-1545)AAT>ATT	p.N515I	MBTPS1_uc002fhh.2_Missense_Mutation_p.N19I	NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	515	Lumenal (Potential).				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						GATGGTGACATTAACAACTGT	0.478000													16	27					0	0	0	0
JPH3	57338	broad.mit.edu	37	16	87678544	87678544	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr16:87678544C>T	uc002fkd.2	+	2	1317	c.1063C>T	c.(1063-1065)CGG>TGG	p.R355W	JPH3_uc010vou.1_RNA	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	355	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)		CATCCCCCTGCGGGCCAGCAA	0.652000													10	24					0	0	0	0
ZC3H18	124245	broad.mit.edu	37	16	88664701	88664701	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr16:88664701C>T	uc002fky.2	+	4	1004	c.804C>T	c.(802-804)CTC>CTT	p.L268L	ZC3H18_uc010voy.1_Silent_p.L151L|ZC3H18_uc010voz.1_Silent_p.L292L	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	268	Pro-rich.					nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		CCCCGCCTCTCGGACCTCACC	0.537000													6	62					0	0	0	0
RPA1	6117	broad.mit.edu	37	17	1783840	1783840	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr17:1783840G>A	uc002fto.2	+	12	1211	c.1096G>A	c.(1096-1098)GAT>AAT	p.D366N		NM_002945	NP_002936	P27694	RFA1_HUMAN	replication protein A1	366					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding				0						TTTACAGGCTGATAAATTTGA	0.428000								NER					16	33					0	0	0	0
NEURL4	84461	broad.mit.edu	37	17	7230539	7230539	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr17:7230539C>T	uc002gga.1	-	3	745	c.738G>A	c.(736-738)GTG>GTA	p.V246V	NEURL4_uc002ggb.1_Silent_p.V246V|NEURL4_uc002ggc.1_5'Flank	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	246							protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						GCGCTGGGGACACCATGAAGG	0.627000													8	16					0	0	0	0
POLR2A	5430	broad.mit.edu	37	17	7399540	7399540	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr17:7399540G>C	uc002ghf.3	+	3	472	c.238G>C	c.(238-240)GAG>CAG	p.E80Q	POLR2A_uc002ghe.2_Missense_Mutation_p.E80Q	NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	80					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				AAACATGACAGAGTGTCCTGG	0.537000													6	48					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578413	7578413	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr17:7578413C>A	uc002gim.2	-	5	711	c.517G>T	c.(517-519)GTG>TTG	p.V173L	TP53_uc002gig.1_Missense_Mutation_p.V173L|TP53_uc002gih.2_Missense_Mutation_p.V173L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V41L|TP53_uc010cng.1_Missense_Mutation_p.V41L|TP53_uc002gii.1_Missense_Mutation_p.V41L|TP53_uc010cnh.1_Missense_Mutation_p.V173L|TP53_uc010cni.1_Missense_Mutation_p.V173L|TP53_uc002gij.2_Missense_Mutation_p.V173L|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V80L|TP53_uc002gio.2_Missense_Mutation_p.V41L|TP53_uc010vug.1_Missense_Mutation_p.V134L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	173	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> M (in LFS; germline mutation and in sporadic cancers; somatic mutation).|V -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|V -> E (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> A (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V173L(54)|p.V173M(40)|p.V173A(8)|p.V173V(8)|p.0?(7)|p.V173G(6)|p.V173fs*1(4)|p.V80L(2)|p.V173fs*59(2)|p.V41L(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V172_R174delVVR(1)|p.V173fs*69(1)|p.P151_V173del23(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.V173E(1)|p.E171fs*1(1)|p.V173W(1)|p.V173fs*8(1)|p.H168fs*69(1)|p.V80M(1)|p.E171_H179delEVVRRCPHH(1)|p.S149fs*72(1)|p.V41M(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCGCCTCACAACCTCCGTC	0.662000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			31	22					9.65021e-13	1.86472e-12	1	0
DNAH2	146754	broad.mit.edu	37	17	7637808	7637808	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr17:7637808C>T	uc002giu.1	+	6	774	c.760C>T	c.(760-762)CGG>TGG	p.R254W	DNAH2_uc002git.2_Missense_Mutation_p.R254W|DNAH2_uc010vuk.1_Missense_Mutation_p.R254W	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	254	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CCACTGGACCCGGCAGATAAA	0.537000													9	38					0	0	0	0
KDM6B	23135	broad.mit.edu	37	17	7752018	7752018	+	Silent	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr17:7752018C>G	uc002giw.1	+	11	2788	c.2412C>G	c.(2410-2412)CTC>CTG	p.L804L	KDM6B_uc002gix.2_Silent_p.L106L	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	804	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CCAGCCTGCTCAAATCCTTGG	0.363000													6	52					0	0	0	0
CHD3	1107	broad.mit.edu	37	17	7794330	7794330	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr17:7794330G>A	uc002gje.2	+	4	607	c.457G>A	c.(457-459)GAG>AAG	p.E153K	CHD3_uc002gjd.2_Missense_Mutation_p.E212K|CHD3_uc002gjf.2_Missense_Mutation_p.E153K|CHD3_uc002gjg.1_5'UTR	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	153					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				TGTGTTCTCTGAGGAGGATTA	0.512000													28	70					0	0	0	0
MYH8	4626	broad.mit.edu	37	17	10309390	10309390	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr17:10309390C>G	uc002gmm.2	-	21	2495	c.2400G>C	c.(2398-2400)ATG>ATC	p.M800I	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	800	IQ.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						ATTCTACCCTCATTAGGAATC	0.373000									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				8	66					0	0	0	0
DNAH9	1770	broad.mit.edu	37	17	11607549	11607549	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr17:11607549G>A	uc002gne.2	+	25	5249	c.5181G>A	c.(5179-5181)TGG>TGA	p.W1727*	DNAH9_uc010coo.2_Nonsense_Mutation_p.W1021*	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1727	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGATCTGGTGGACAACAGAAG	0.507000													5	112					0	0	0	0
PRPSAP2	5636	broad.mit.edu	37	17	18775924	18775924	+	Silent	SNP	G	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr17:18775924G>T	uc002gup.1	+	5	412	c.201G>T	c.(199-201)GTG>GTT	p.V67V	PRPSAP2_uc002guo.1_5'UTR|PRPSAP2_uc010vyi.1_Intron|PRPSAP2_uc010vyj.1_5'UTR|PRPSAP2_uc010vyk.1_Silent_p.V55V	NM_002767	NP_002758	O60256	KPRB_HUMAN	phosphoribosyl pyrophosphate	67					nucleotide biosynthetic process		enzyme inhibitor activity|magnesium ion binding|ribose phosphate diphosphokinase activity			skin(1)	1						AAGAGTCTGTGAGGGGAAAAG	0.348000													41	168					1.57019e-19	3.09116e-19	1	0
KIAA0100	9703	broad.mit.edu	37	17	26965108	26965108	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr17:26965108C>G	uc002hbu.2	-	14	1616	c.1517G>C	c.(1516-1518)AGC>ACC	p.S506T		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	506						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					CTGGTTATAGCTACCCTAGAG	0.498000													12	54					0	0	0	0
KRT27	342574	broad.mit.edu	37	17	38938473	38938473	+	Silent	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr17:38938473G>C	uc002hvg.2	-	1	314	c.273C>G	c.(271-273)CTC>CTG	p.L91L		NM_181537	NP_853515	Q7Z3Y8	K1C27_HUMAN	keratin 27	91	Rod.|Coil 1A.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.000812)				AGCGGTCGTTGAGGTTCTGCA	0.572000													33	63					0	0	0	0
DHX8	1659	broad.mit.edu	37	17	41585799	41585799	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr17:41585799C>T	uc002idu.1	+	16	2486	c.2413C>T	c.(2413-2415)CCA>TCA	p.P805S	DHX8_uc010wif.1_Missense_Mutation_p.P714S|DHX8_uc010wig.1_Missense_Mutation_p.P805S	NM_004941	NP_004932	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	805	Helicase C-terminal.					catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		ACCTGATGTTCCAGAGTTAAT	0.488000													13	61					0	0	0	0
ARHGAP27	201176	broad.mit.edu	37	17	43480174	43480174	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr17:43480174G>A	uc002iix.2	-	9	1075	c.626C>T	c.(625-627)TCC>TTC	p.S209F	ARHGAP27_uc010dak.2_Missense_Mutation_p.S182F|ARHGAP27_uc010wjl.1_Missense_Mutation_p.S328F	NM_199282	NP_954976	Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27 isoform a	550	PH.				positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding				0	Renal(3;0.0405)					GGAAAACTTGGAAGGCTGCCT	0.572000													19	38					0	0	0	0
ABCA8	10351	broad.mit.edu	37	17	66890418	66890418	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr17:66890418T>C	uc002jhp.2	-	21	2991	c.2812A>G	c.(2812-2814)AGA>GGA	p.R938G	ABCA8_uc002jhq.2_Missense_Mutation_p.R978G|ABCA8_uc010wqq.1_Missense_Mutation_p.R978G|ABCA8_uc010wqr.1_Missense_Mutation_p.R917G|ABCA8_uc002jhr.2_Missense_Mutation_p.R978G	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	938						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					CAATTCAATCTTTTGGCATTG	0.313000													7	14					0	0	0	0
NOL4	8715	broad.mit.edu	37	18	31523045	31523045	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr18:31523045C>T	uc010dmi.2	-	9	1755	c.1526G>A	c.(1525-1527)CGT>CAT	p.R509H	NOL4_uc010xbs.1_Missense_Mutation_p.R224H|NOL4_uc002kxr.3_Missense_Mutation_p.R281H|NOL4_uc010xbt.1_Missense_Mutation_p.R435H|NOL4_uc010dmh.2_Missense_Mutation_p.R371H|NOL4_uc010xbu.1_Missense_Mutation_p.R445H|NOL4_uc002kxt.3_Intron|NOL4_uc010xbv.1_Missense_Mutation_p.R194H	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	509						nucleolus	RNA binding			ovary(3)	3						TCTCTCCAGACGCATCCTCTT	0.443000													10	56					0	0	0	0
DTNA	1837	broad.mit.edu	37	18	32428280	32428280	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr18:32428280G>A	uc010dmn.1	+	13	1287	c.1286G>A	c.(1285-1287)CGG>CAG	p.R429Q	DTNA_uc010xbx.1_Intron|DTNA_uc002kxv.3_Missense_Mutation_p.R372Q|DTNA_uc002kxw.2_Missense_Mutation_p.R372Q|DTNA_uc010dmj.2_Missense_Mutation_p.R369Q|DTNA_uc002kxz.2_Missense_Mutation_p.R369Q|DTNA_uc002kxy.2_Missense_Mutation_p.R369Q|DTNA_uc010dml.2_Missense_Mutation_p.R369Q|DTNA_uc002kyb.3_Missense_Mutation_p.R426Q|DTNA_uc010dmm.2_Missense_Mutation_p.R429Q|DTNA_uc010xby.1_Missense_Mutation_p.R119Q|DTNA_uc010dmo.2_Missense_Mutation_p.R51Q|DTNA_uc002kyd.3_Missense_Mutation_p.R51Q|DTNA_uc010xbz.1_Missense_Mutation_p.R138Q|DTNA_uc010xca.1_Missense_Mutation_p.R81Q|DTNA_uc002kye.2_Missense_Mutation_p.R77Q	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	429	Syntrophin-binding region.				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						AGTTCAAACCGGCTTGATGAA	0.448000													20	24					0	0	0	0
CDH19	28513	broad.mit.edu	37	18	64178908	64178908	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr18:64178908G>A	uc002lkc.1	-	10	1611	c.1473C>T	c.(1471-1473)ATC>ATT	p.I491I	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Intron	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	491	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				CCACTGCACTGATAGTCTGAA	0.318000													20	32					0	0	0	0
SHD	56961	broad.mit.edu	37	19	4282869	4282869	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr19:4282869G>A	uc002lzw.2	+	2	1763	c.300G>A	c.(298-300)CTG>CTA	p.L100L	SHD_uc010dtu.2_Silent_p.L100L	NM_020209	NP_064594	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming	100											0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCCGCAGCTGGAAGCCGACA	0.572000													32	54					0	0	0	0
CD320	51293	broad.mit.edu	37	19	8367860	8367860	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr19:8367860G>A	uc002mjj.1	-	4	572	c.507C>T	c.(505-507)ACC>ACT	p.T169T	CD320_uc002mjk.1_RNA|CD320_uc002mjl.1_Silent_p.T127T	NM_016579	NP_057663	Q9NPF0	CD320_HUMAN	8D6 antigen isoform 1 precursor	169	Extracellular (Potential).				regulation of cell growth	endoplasmic reticulum|integral to membrane	growth factor activity				0						GGATCTCATTGGTTCCTGCAA	0.607000													4	15					0	0	0	0
ZNF266	10781	broad.mit.edu	37	19	9524534	9524534	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr19:9524534T>G	uc002mll.2	-	4	1333	c.1067A>C	c.(1066-1068)GAT>GCT	p.D356A	ZNF266_uc002mlm.2_Missense_Mutation_p.D356A|ZNF266_uc002mln.2_Missense_Mutation_p.D356A|ZNF266_uc002mlo.2_Missense_Mutation_p.D356A|ZNF266_uc010dwp.2_Missense_Mutation_p.D356A|ZNF266_uc010dwq.2_Missense_Mutation_p.D356A	NM_198058	NP_932175	Q14584	ZN266_HUMAN	zinc finger protein 266	356	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTTCCCACAATCCTTACATTT	0.413000													18	46					0	0	0	0
ZNF442	79973	broad.mit.edu	37	19	12461237	12461237	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr19:12461237G>C	uc002mtr.1	-	6	1773	c.1162C>G	c.(1162-1164)CAT>GAT	p.H388D	ZNF442_uc010xmk.1_Missense_Mutation_p.H319D	NM_030824	NP_110451	Q9H7R0	ZN442_HUMAN	zinc finger protein 442	388	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|breast(1)|kidney(1)	4						CTTGAGTGATGAGATAACGCT	0.428000													9	168					0	0	0	0
MAST1	22983	broad.mit.edu	37	19	12969220	12969220	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr19:12969220C>T	uc002mvm.2	+	11	1250	c.1122C>T	c.(1120-1122)TTC>TTT	p.F374F	MAST1_uc002mvk.2_Silent_p.F370F	NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	374	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						AGAATGACTTCGATACCATCA	0.582000													21	131					0	0	0	0
ZNF708	7562	broad.mit.edu	37	19	21492100	21492100	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr19:21492100T>A	uc002npq.1	-	3	372	c.174A>T	c.(172-174)CAA>CAT	p.Q58H	ZNF708_uc002npr.1_Translation_Start_Site|ZNF708_uc010ecs.1_Translation_Start_Site	NM_021269	NP_067092	P17019	ZN708_HUMAN	zinc finger protein 708	58	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(4)|skin(2)	6						GCTCTTTTCCTTGCTCCAGAC	0.428000													24	72					0	0	0	0
ZNF493	284443	broad.mit.edu	37	19	21606747	21606747	+	Missense_Mutation	SNP	G	C	C	rs143136118		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr19:21606747G>C	uc002npx.2	+	2	1182	c.902G>C	c.(901-903)GGA>GCA	p.G301A	ZNF493_uc002npw.2_Missense_Mutation_p.G429A|ZNF493_uc002npy.2_Missense_Mutation_p.G301A	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	301					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATTCATACTGGAGAGAAACCC	0.338000													3	30					0	0	0	0
ZNF91	7644	broad.mit.edu	37	19	23542840	23542840	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr19:23542840G>A	uc002nre.2	-	4	3054	c.2941C>T	c.(2941-2943)CTT>TTT	p.L981F	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Missense_Mutation_p.L949F	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	981	C2H2-type 30.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TGTTCAGTAAGAGTTGAAGAT	0.378000													5	48					0	0	0	0
KIRREL2	84063	broad.mit.edu	37	19	36355599	36355599	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr19:36355599G>A	uc002ocb.3	+	14	1987	c.1775G>A	c.(1774-1776)GGG>GAG	p.G592E	KIRREL2_uc002obz.3_Missense_Mutation_p.G592E|KIRREL2_uc002oca.3_Missense_Mutation_p.G542E|KIRREL2_uc002occ.3_Missense_Mutation_p.G539E|KIRREL2_uc002ocd.3_Missense_Mutation_p.G554E	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	592	Cytoplasmic (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GAGGAGAAAGGGACTCTGGAG	0.597000													26	16					0	0	0	0
PSG5	5673	broad.mit.edu	37	19	43688992	43688992	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr19:43688992G>C	uc002ovu.2	-	2	503	c.372C>G	c.(370-372)ATC>ATG	p.I124M	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Missense_Mutation_p.I52M|PSG5_uc002ovx.2_Missense_Mutation_p.I124M|PSG5_uc002ovv.2_Missense_Mutation_p.I124M|PSG5_uc002ovw.2_Missense_Mutation_p.I124M	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	124	Ig-like V-type.				female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				CTCGCTTTATGATGTGTAAGG	0.493000													114	238					0	0	0	0
ZNF233	353355	broad.mit.edu	37	19	44777511	44777511	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr19:44777511C>A	uc002oyz.1	+	5	825	c.698C>A	c.(697-699)GCT>GAT	p.A233D	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Missense_Mutation_p.A48D	NM_181756	NP_861421	A6NK53	ZN233_HUMAN	zinc finger protein 233	233					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)				AGAGAGAAAGCTTTTAGCCAC	0.368000													9	26					0.000274275	0.000502171	1	0
SFRS16	11129	broad.mit.edu	37	19	45563652	45563652	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr19:45563652T>A	uc002pak.2	+	9	814	c.716T>A	c.(715-717)CTC>CAC	p.L239H	SFRS16_uc002pal.2_RNA|SFRS16_uc010xxh.1_Missense_Mutation_p.L177H|SFRS16_uc002pam.2_Missense_Mutation_p.L239H|SFRS16_uc002pan.1_RNA	NM_007056	NP_008987	Q8N2M8	CLASR_HUMAN	splicing factor, arginine/serine-rich 16	239					mRNA processing|RNA splicing	nucleus					0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TATAGGATGCTCCGGAAAGAC	0.572000													8	28					0	0	0	0
SYMPK	8189	broad.mit.edu	37	19	46328447	46328447	+	Silent	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr19:46328447C>G	uc002pdn.2	-	18	2717	c.2472G>C	c.(2470-2472)CTG>CTC	p.L824L	SYMPK_uc002pdo.1_Silent_p.L824L|SYMPK_uc002pdp.1_Silent_p.L824L	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	824					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		CAATGACCCTCAGCACCGTCC	0.647000													5	66					0	0	0	0
GRLF1	2909	broad.mit.edu	37	19	47503732	47503732	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr19:47503732C>G	uc010ekv.2	+	6	4287	c.4287C>G	c.(4285-4287)ATC>ATG	p.I1429M		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	1429	Rho-GAP.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		AACTCTTTATCCAGCAGTGCC	0.597000													30	103					0	0	0	0
NUP62	23636	broad.mit.edu	37	19	50412910	50412910	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr19:50412910G>C	uc002pqx.2	-	2	259	c.155C>G	c.(154-156)ACA>AGA	p.T52R	IL4I1_uc002pqv.1_Intron|IL4I1_uc010eno.1_Intron|IL4I1_uc002pqw.1_Intron|IL4I1_uc002pqu.1_Intron|NUP62_uc002pqy.2_Missense_Mutation_p.T52R|NUP62_uc002pqz.2_Missense_Mutation_p.T52R|NUP62_uc002pra.2_Missense_Mutation_p.T52R|NUP62_uc002prb.2_Missense_Mutation_p.T52R|NUP62_uc002prc.2_Missense_Mutation_p.T52R	NM_153719	NP_714941	P37198	NUP62_HUMAN	nucleoporin 62kDa	52	15 X 9 AA approximate repeats.|Thr-rich.				carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding				0		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		AGGGGTACTTGTGGCTGGTTG	0.567000													7	134					0	0	0	0
SIGLEC5	8778	broad.mit.edu	37	19	52115506	52115506	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr19:52115506G>A	uc002pxe.2	-	9	1773	c.1634C>T	c.(1633-1635)TCG>TTG	p.S545L		NM_003830	NP_003821	O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5 precursor	545	SLAM-like motif.|Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding			skin(2)|breast(1)|central_nervous_system(1)	4		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		CTTGATCTCCGAGTACTCCGT	0.537000													16	80					0	0	0	0
APOB	338	broad.mit.edu	37	2	21224885	21224885	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:21224885G>A	uc002red.2	-	29	13537	c.13409C>T	c.(13408-13410)TCT>TTT	p.S4470F		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4470					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AGCAGTGGCAGAAAGCTCTGC	0.383000													12	71					0	0	0	0
PFN4	375189	broad.mit.edu	37	2	24345335	24345335	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:24345335A>T	uc002rfa.1	-	2	247	c.71T>A	c.(70-72)ATC>AAC	p.I24N	LOC375190_uc002rew.2_Intron|LOC375190_uc010ykl.1_5'Flank|LOC375190_uc002rfb.2_5'Flank	NM_199346	NP_955378	Q8NHR9	PROF4_HUMAN	profilin family, member 4	24					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGGATTTTGATGAGGGCTGC	0.428000													65	49					0	0	0	0
DNMT3A	1788	broad.mit.edu	37	2	25463307	25463307	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:25463307C>T	uc002rgc.2	-	19	2443	c.2186G>A	c.(2185-2187)CGG>CAG	p.R729Q	DNMT3A_uc002rgd.2_Missense_Mutation_p.R729Q|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Missense_Mutation_p.R540Q	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	729					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding	p.R729Q(1)|p.R729W(1)		haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAAGAAGAGCCGGCCAGTGCC	0.612000			Mis|F|N|S		AML								30	28					0	0	0	0
EHBP1	23301	broad.mit.edu	37	2	63217961	63217961	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:63217961G>A	uc002sby.2	+	18	3414	c.2932G>A	c.(2932-2934)GAG>AAG	p.E978K	EHBP1_uc010fcp.2_Missense_Mutation_p.E907K|EHBP1_uc002sbz.2_Missense_Mutation_p.E907K|EHBP1_uc002scb.2_Missense_Mutation_p.E943K	NM_015252	NP_056067	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1 isoform 1	978						cytoplasm|membrane				ovary(1)|breast(1)	2	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			TGAGAGCTCAGAGCAGGACAT	0.418000									Hereditary_Prostate_Cancer				6	38					0	0	0	0
MEIS1	4211	broad.mit.edu	37	2	66775128	66775128	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:66775128C>T	uc002sdu.2	+	9	1399	c.942C>T	c.(940-942)CTC>CTT	p.L314L	MEIS1_uc002sdt.2_Silent_p.L314L|MEIS1_uc002sdv.2_Silent_p.L312L|MEIS1_uc010yqh.1_RNA|MEIS1_uc010yqi.1_Silent_p.L249L|MEIS1_uc002sdw.1_Silent_p.L170L	NM_002398	NP_002389	O00470	MEIS1_HUMAN	Meis homeobox 1	314	Homeobox; TALE-type.						sequence-specific DNA binding transcription factor activity				0						ACACGGGACTCACCATCCTTC	0.423000													13	31					0	0	0	0
ASPRV1	151516	broad.mit.edu	37	2	70188034	70188034	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:70188034G>A	uc002sfz.3	-	1	1364	c.787C>T	c.(787-789)CTA>TTA	p.L263L		NM_152792	NP_690005	Q53RT3	APRV1_HUMAN	aspartic peptidase, retroviral-like 1 precursor	263	Peptidase A2.|Extracellular (Potential).				protein maturation by peptide bond cleavage|skin development		aspartic-type endopeptidase activity			ovary(1)	1						AGCTTGCCTAGGGACACCGCT	0.542000													25	60					0	0	0	0
ZNF638	27332	broad.mit.edu	37	2	71653623	71653623	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:71653623G>T	uc002shx.2	+	24	4943	c.4624G>T	c.(4624-4626)GTT>TTT	p.V1542F	ZNF638_uc002shy.2_Missense_Mutation_p.V1542F|ZNF638_uc002shz.2_Missense_Mutation_p.V1542F|ZNF638_uc002sia.2_Missense_Mutation_p.V1542F|ZNF638_uc002sib.1_Missense_Mutation_p.L1133F|ZNF638_uc010fed.2_Intron|ZNF638_uc002sic.2_Missense_Mutation_p.V639F|ZNF638_uc002sid.2_5'UTR	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	1542					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						GGATGAATTTGTTACTGTGGA	0.348000													18	20					1.56452e-12	3.00465e-12	1	0
REG1B	5968	broad.mit.edu	37	2	79314023	79314023	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:79314023C>G	uc002sny.2	-	3	210	c.98G>C	c.(97-99)CGA>CCA	p.R33P	REG1B_uc010ffv.1_Missense_Mutation_p.R33P|REG1B_uc010ffw.2_Missense_Mutation_p.R33P	NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor	33					cell proliferation	extracellular region	sugar binding	p.R33*(1)		central_nervous_system(1)|skin(1)	2						GCAGCTGATTCGGGGATTAGG	0.498000													68	53					0	0	0	0
CTNNA2	1496	broad.mit.edu	37	2	79878701	79878701	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:79878701C>T	uc010ysh.1	+	1	24	c.19C>T	c.(19-21)CCT>TCT	p.P7S	CTNNA2_uc010yse.1_Missense_Mutation_p.P7S|CTNNA2_uc010ysf.1_Missense_Mutation_p.P7S|CTNNA2_uc010ysg.1_Missense_Mutation_p.P7S|hsa-mir-4264|MI0015877_5'Flank	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	7					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GGCAACTTCACCTATCATTCT	0.403000													24	57					0	0	0	0
WASH2P	375260	broad.mit.edu	37	2	114355998	114355998	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:114355998C>G	uc002tkh.2	+	5	674	c.616C>G	c.(616-618)CAC>GAC	p.H206D	WASH2P_uc002tka.2_RNA|WASH2P_uc002tkb.2_RNA|WASH2P_uc002tkd.2_RNA	NM_182905	NP_878908			WAS protein family homolog 1												0						CCAAGGTGGGCACTTGATGTC	0.612000													3	4					0	0	0	0
DPP10	57628	broad.mit.edu	37	2	116447315	116447315	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:116447315G>A	uc002tla.1	+	6	951	c.494G>A	c.(493-495)AGG>AAG	p.R165K	DPP10_uc002tlb.1_Missense_Mutation_p.R115K|DPP10_uc002tlc.1_Missense_Mutation_p.R161K|DPP10_uc002tle.2_Missense_Mutation_p.R169K|DPP10_uc002tlf.1_Missense_Mutation_p.R158K	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	165	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						ATACACACTAGGTAAGTTCTT	0.264000													4	16					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141260622	141260622	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:141260622G>C	uc002tvj.1	-	54	9544	c.8572C>G	c.(8572-8574)CTT>GTT	p.L2858V		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2858	Extracellular (Potential).|LDL-receptor class A 19.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTATTTAGAAGACACCGCCCA	0.388000										TSP Lung(27;0.18)			20	52					0	0	0	0
MBD5	55777	broad.mit.edu	37	2	149227843	149227843	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:149227843C>T	uc002twm.3	+	9	3319	c.2331C>T	c.(2329-2331)AAC>AAT	p.N777N	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Silent_p.N777N|MBD5_uc002twn.1_Silent_p.N218N	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	777						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		CAGTCCCCAACCACCATCTTG	0.463000													21	63					0	0	0	0
NEB	4703	broad.mit.edu	37	2	152499769	152499769	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:152499769C>G	uc010fnx.2	-	58	8246	c.8055G>C	c.(8053-8055)TTG>TTC	p.L2685F		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2685	Nebulin 72.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CATGGTCACTCAAAATCTGGG	0.413000													3	109					0	0	0	0
XIRP2	129446	broad.mit.edu	37	2	168102261	168102261	+	Silent	SNP	T	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:168102261T>G	uc002udx.2	+	8	4377	c.4359T>G	c.(4357-4359)ACT>ACG	p.T1453T	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.T1278T|XIRP2_uc010fpq.2_Silent_p.T1231T|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1278	Xin 26.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AAACATCTACTTGGCTATTTG	0.348000													10	15					0	0	0	0
GPR155	151556	broad.mit.edu	37	2	175346518	175346518	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:175346518C>G	uc002uit.2	-	3	558	c.167G>C	c.(166-168)GGC>GCC	p.G56A	GPR155_uc002uiu.2_Missense_Mutation_p.G56A|GPR155_uc002uiv.2_Missense_Mutation_p.G56A|GPR155_uc010fqs.2_Missense_Mutation_p.G56A	NM_001033045	NP_001028217	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155 isoform 9	56	Helical; (Potential).				intracellular signal transduction|transmembrane transport	integral to membrane				ovary(1)	1						TGCTATGTAGCCACAAAGGAC	0.418000													12	34					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179395647	179395647	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:179395647G>T	uc010zfg.1	-	307	98215	c.97991C>A	c.(97990-97992)CCA>CAA	p.P32664Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P26359Q|TTN_uc010zfi.1_Missense_Mutation_p.P26292Q|TTN_uc010zfj.1_Missense_Mutation_p.P26167Q|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33591							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGACTCTTGGTGGTGATGT	0.478000													13	141					4.36969e-10	8.24074e-10	1	0
TTN	7273	broad.mit.edu	37	2	179593094	179593094	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:179593094T>G	uc010zfg.1	-	64	15949	c.15725A>C	c.(15724-15726)AAA>ACA	p.K5242T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.K1903T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6169							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGGTTAATTTTTTGGTGAA	0.358000													6	13					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179654776	179654776	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:179654776G>T	uc010zfg.1	-	12	2091	c.1867C>A	c.(1867-1869)CAA>AAA	p.Q623K	TTN_uc010zfh.1_Missense_Mutation_p.Q577K|TTN_uc010zfi.1_Missense_Mutation_p.Q577K|TTN_uc010zfj.1_Missense_Mutation_p.Q577K|TTN_uc002unb.2_Missense_Mutation_p.Q623K|TTN_uc010frg.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	623							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTAAATCTTGTTCTTTGACT	0.348000													18	27					3.51602e-12	6.73189e-12	1	0
TTN	7273	broad.mit.edu	37	2	179655440	179655440	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:179655440C>T	uc010zfg.1	-	11	2019	c.1795G>A	c.(1795-1797)GAA>AAA	p.E599K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002unb.2_Missense_Mutation_p.E599K|TTN_uc010frg.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	599							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCACCTTTTCATAACTTAGG	0.408000													6	82					0	0	0	0
PMS1	5378	broad.mit.edu	37	2	190719576	190719576	+	Silent	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:190719576T>C	uc002urh.3	+	9	2107	c.1578T>C	c.(1576-1578)TGT>TGC	p.C526C	PMS1_uc010zga.1_Silent_p.C487C|PMS1_uc010zgb.1_Silent_p.C465C|PMS1_uc002urk.3_Silent_p.C487C|PMS1_uc002uri.3_Silent_p.C526C|PMS1_uc010zgc.1_Silent_p.C350C|PMS1_uc010zgd.1_Silent_p.C350C|PMS1_uc002urj.2_RNA|PMS1_uc010fry.1_Silent_p.C487C|PMS1_uc010frz.2_Intron|PMS1_uc002url.2_Silent_p.C311C|PMS1_uc002urm.2_RNA|PMS1_uc002urn.1_Silent_p.C194C	NM_000534	NP_000525	P54277	PMS1_HUMAN	postmeiotic segregation 1 isoform a	526					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			GTTTACCATGTAAAGTAAGTA	0.294000			Mis|N			colorectal|endometrial|ovarian		Direct_reversal_of_damage|MMR					12	30					0	0	0	0
STAT1	6772	broad.mit.edu	37	2	191863005	191863005	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:191863005C>T	uc002usj.2	-	8	959	c.571G>A	c.(571-573)GAT>AAT	p.D191N	STAT1_uc010fse.1_Missense_Mutation_p.D191N|STAT1_uc002usk.2_Missense_Mutation_p.D191N|STAT1_uc002usl.2_Missense_Mutation_p.D193N|STAT1_uc010fsf.1_Intron	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	191					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	TGTTTCTGATCACTCTTTGCC	0.338000													7	64					0	0	0	0
DNAH7	56171	broad.mit.edu	37	2	196664153	196664153	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:196664153C>T	uc002utj.3	-	55	10321	c.10220G>A	c.(10219-10221)CGT>CAT	p.R3407H		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3407	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AATGAATGCACGTCCCAATCT	0.418000													28	75					0	0	0	0
GTF3C3	9330	broad.mit.edu	37	2	197641315	197641315	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:197641315C>T	uc002uts.2	-	11	1519	c.1429G>A	c.(1429-1431)GAA>AAA	p.E477K	GTF3C3_uc010zgu.1_Missense_Mutation_p.E448K	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	477	TPR 8.					transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7						CCATAGCTTTCAGCAGCTCGC	0.438000													5	87					0	0	0	0
FN1	2335	broad.mit.edu	37	2	216286886	216286886	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:216286886G>C	uc002vfa.2	-	10	1740	c.1474C>G	c.(1474-1476)CAC>GAC	p.H492D	FN1_uc002vfb.2_Missense_Mutation_p.H492D|FN1_uc002vfc.2_Missense_Mutation_p.H492D|FN1_uc002vfd.2_Missense_Mutation_p.H492D|FN1_uc002vfe.2_Missense_Mutation_p.H492D|FN1_uc002vff.2_Missense_Mutation_p.H492D|FN1_uc002vfg.2_Missense_Mutation_p.H492D|FN1_uc002vfh.2_Missense_Mutation_p.H492D|FN1_uc002vfi.2_Missense_Mutation_p.H492D|FN1_uc002vfj.2_Missense_Mutation_p.H492D|FN1_uc002vfl.2_Missense_Mutation_p.H492D	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	492	Collagen-binding.|Fibronectin type-I 7.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTCATCATGTGACCCATGTCA	0.478000													21	100					0	0	0	0
SP140	11262	broad.mit.edu	37	2	231112644	231112644	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:231112644C>T	uc002vql.2	+	8	871	c.756C>T	c.(754-756)AAC>AAT	p.N252N	SP140_uc010zma.1_Intron|SP140_uc002vqk.2_Silent_p.N252N|SP140_uc002vqn.2_Intron|SP140_uc002vqm.2_Silent_p.N226N|SP140_uc010fxl.2_Silent_p.N252N	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	252					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TAGAAAGCAACGGGATGATAG	0.443000													32	70					0	0	0	0
GBX2	2637	broad.mit.edu	37	2	237075004	237075004	+	Silent	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:237075004C>A	uc002vvw.1	-	2	638	c.600G>T	c.(598-600)TCG>TCT	p.S200S	GBX2_uc010zng.1_Missense_Mutation_p.A203S	NM_001485	NP_001476	P52951	GBX2_HUMAN	gastrulation brain homeo box 2	200						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Breast(86;0.00235)|Renal(207;0.00339)|all_hematologic(139;0.00357)|all_lung(227;0.0616)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|Lung NSC(271;0.179)		Epithelial(121;4.5e-25)|OV - Ovarian serous cystadenocarcinoma(60;5.16e-11)|BRCA - Breast invasive adenocarcinoma(100;3.4e-05)|Lung(119;0.00195)|LUSC - Lung squamous cell carcinoma(224;0.00471)		CGCTCTCCAGCGAGAAGCTCT	0.602000													39	79					2.75727e-19	5.39429e-19	1	0
TGM6	343641	broad.mit.edu	37	20	2375175	2375175	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr20:2375175G>A	uc002wfy.1	+	2	146	c.85G>A	c.(85-87)GAG>AAG	p.E29K	TGM6_uc010gal.1_Missense_Mutation_p.E29K	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	29					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	CCCCTGCCCTGAGCTGGTGGT	0.627000													4	30					0	0	0	0
TM9SF4	9777	broad.mit.edu	37	20	30729430	30729430	+	Silent	SNP	C	T	T	rs117023270	by1000genomes	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr20:30729430C>T	uc002wxj.2	+	4	595	c.360C>T	c.(358-360)CTC>CTT	p.L120L	TM9SF4_uc010ztr.1_Silent_p.L46L|TM9SF4_uc010zts.1_Silent_p.L27L|TM9SF4_uc002wxk.2_Silent_p.L103L|TM9SF4_uc010gdz.2_Silent_p.L27L	NM_014742	NP_055557	Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	120						integral to membrane				central_nervous_system(1)|pancreas(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AGAGCCGACTCGTGGCCGAGC	0.577000													9	137					0	0	0	0
NCOA6	23054	broad.mit.edu	37	20	33329653	33329653	+	Silent	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr20:33329653T>C	uc002xav.2	-	12	6978	c.4407A>G	c.(4405-4407)AAA>AAG	p.K1469K	NCOA6_uc002xaw.2_Silent_p.K1469K	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1469					brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						CACTGGGAAGTTTGTTAGGAT	0.448000													31	140					0	0	0	0
KIAA1755	85449	broad.mit.edu	37	20	36850870	36850870	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr20:36850870C>G	uc002xhy.1	-	10	2670	c.2398G>C	c.(2398-2400)GAC>CAC	p.D800H	KIAA1755_uc002xhx.1_Missense_Mutation_p.D78H	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	800										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				GGGCTGAAGTCCAGCCTGCTG	0.642000											OREG0025921	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	95					0	0	0	0
PLCG1	5335	broad.mit.edu	37	20	39791883	39791883	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr20:39791883G>C	uc002xjp.1	+	8	878	c.757G>C	c.(757-759)GAG>CAG	p.E253Q	PLCG1_uc002xjo.1_Missense_Mutation_p.E253Q|PLCG1_uc010zwe.1_5'Flank|PLCG1_uc010ggf.2_5'Flank	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	253					activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				GTCCCTTCCTGAGTTCCAGCA	0.607000													20	111					0	0	0	0
SLCO4A1	28231	broad.mit.edu	37	20	61292481	61292481	+	Missense_Mutation	SNP	G	A	A	rs138628669		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr20:61292481G>A	uc002ydb.1	+	5	1280	c.1075G>A	c.(1075-1077)GAG>AAG	p.E359K	SLCO4A1_uc002ydc.1_RNA	NM_016354	NP_057438	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family	359	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(1)	1	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			CAGCCGTGGGGAGGCGAGCAA	0.617000													30	67					0	0	0	0
DIDO1	11083	broad.mit.edu	37	20	61541176	61541176	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr20:61541176C>G	uc002ydr.1	-	4	1300	c.1036G>C	c.(1036-1038)GAT>CAT	p.D346H	DIDO1_uc002yds.1_Missense_Mutation_p.D346H|DIDO1_uc002ydt.1_Missense_Mutation_p.D346H|DIDO1_uc002ydu.1_Missense_Mutation_p.D346H|DIDO1_uc002ydv.1_Missense_Mutation_p.D346H|DIDO1_uc002ydw.1_Missense_Mutation_p.D346H|DIDO1_uc002ydx.1_Missense_Mutation_p.D346H|DIDO1_uc011aao.1_Missense_Mutation_p.D346H	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	346					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					TCGGTGCCATCAGCATCTCCA	0.458000													7	170					0	0	0	0
SAMD10	140700	broad.mit.edu	37	20	62608706	62608706	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr20:62608706C>T	uc002yhm.2	-	2	320	c.145G>A	c.(145-147)GAG>AAG	p.E49K	SAMD10_uc002yhn.2_RNA	NM_080621	NP_542188	Q9BYL1	SAM10_HUMAN	sterile alpha motif domain containing 10	49											0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					GGGATGCTCTCAGCTGACACC	0.652000													9	92					0	0	0	0
GABPA	2551	broad.mit.edu	37	21	27130510	27130510	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr21:27130510G>A	uc002ylx.3	+	6	1270	c.743G>A	c.(742-744)CGA>CAA	p.R248Q	GABPA_uc002yly.3_Missense_Mutation_p.R248Q	NM_002040	NP_002031	Q06546	GABPA_HUMAN	GA binding protein transcription factor, alpha	248	PNT.				positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)|central_nervous_system(1)	2						GAACTTCTCCGAAAATGTATG	0.328000													13	28					0	0	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28338237	28338237	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr21:28338237G>A	uc002ymg.2	-	1	1203	c.474C>T	c.(472-474)GTC>GTT	p.V158V		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	158					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						GCGCGTGCTTGACCGCGAAGA	0.657000													7	26					0	0	0	0
WRB	7485	broad.mit.edu	37	21	40762689	40762689	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr21:40762689G>A	uc002yxs.2	+	2	266	c.168G>A	c.(166-168)ATG>ATA	p.M56I	WRB_uc011aeo.1_RNA|WRB_uc011aep.1_Missense_Mutation_p.M56I|WRB_uc002yxt.3_Missense_Mutation_p.M22I|WRB_uc010goj.2_RNA	NM_004627	NP_004618	O00258	WRB_HUMAN	tryptophan rich basic protein isoform 1	56	Potential.					integral to membrane|nucleolus					0		Prostate(19;1.2e-06)				TCCAGGACATGAAGCAGGAGC	0.542000													4	28					0	0	0	0
SLC19A1	6573	broad.mit.edu	37	21	46951984	46951984	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr21:46951984G>A	uc002zhl.1	-	3	387	c.268C>T	c.(268-270)CTG>TTG	p.L90L	SLC19A1_uc010gpy.1_Silent_p.L90L|SLC19A1_uc011aft.1_Silent_p.L50L|SLC19A1_uc002zhm.1_Silent_p.L90L|SLC19A1_uc010gpz.1_5'UTR	NM_194255	NP_919231	P41440	S19A1_HUMAN	solute carrier family 19 member 1	90	Cytoplasmic (Probable).				folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity				0				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		GTGTAGCGCAGGTAGTCGGTG	0.672000													16	28					0	0	0	0
psiTPTE22	387590	broad.mit.edu	37	22	17119533	17119533	+	RNA	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr22:17119533G>A	uc002zls.1	+	2		c.370G>A			psiTPTE22_uc002zlr.2_RNA|psiTPTE22_uc002zlt.2_RNA					Homo sapiens cDNA FLJ10437 fis, clone NT2RP1000581.												0						AATTTTCACTGACAGCAAACT	0.323000													17	58					0	0	0	0
DGCR2	9993	broad.mit.edu	37	22	19076905	19076905	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr22:19076905C>T	uc002zoq.1	-	2	426	c.178G>A	c.(178-180)GAG>AAG	p.E60K	DGCR2_uc002zor.1_5'UTR|DGCR2_uc011agr.1_Intron	NM_005137	NP_005128	P98153	IDD_HUMAN	integral membrane protein DGCR2 precursor	60	Extracellular (Potential).|LDL-receptor class A.				cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			large_intestine(1)	1	Colorectal(54;0.0993)					TCGTCGCTCTCATCCTCGCAA	0.607000													14	123					0	0	0	0
CLTCL1	8218	broad.mit.edu	37	22	19183840	19183840	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr22:19183840G>A	uc002zpb.2	-	27	4203	c.4128C>T	c.(4126-4128)CTC>CTT	p.L1376L	CLTCL1_uc011agv.1_Silent_p.L1376L|CLTCL1_uc011agw.1_Silent_p.L1355L|CLTCL1_uc011agt.1_Silent_p.L167L|CLTCL1_uc011agu.1_Silent_p.L167L|CLTCL1_uc010grm.1_Silent_p.L136L|CLTCL1_uc002zpe.2_3'UTR|CLTCL1_uc002zpd.1_Silent_p.L283L	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	1376	Involved in binding clathrin light chain (By similarity).|Proximal segment.|Heavy chain arm.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					TCATCATGGTGAGCACAGCAT	0.567000			T	?	ALCL								8	72					0	0	0	0
CLTCL1	8218	broad.mit.edu	37	22	19209480	19209480	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr22:19209480C>G	uc002zpb.2	-	16	2630	c.2555G>C	c.(2554-2556)AGA>ACA	p.R852T	CLTCL1_uc011agv.1_Missense_Mutation_p.R852T|CLTCL1_uc011agw.1_Missense_Mutation_p.R852T	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	852	Proximal segment.|Heavy chain arm.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					TTACCTATTTCTTTTTTCTAC	0.418000			T	?	ALCL								7	106					0	0	0	0
TBX1	6899	broad.mit.edu	37	22	19766783	19766783	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr22:19766783G>A	uc002zqb.2	+	9	1179	c.1050G>A	c.(1048-1050)ACG>ACA	p.T350T	TBX1_uc002zqc.2_Intron	NM_080646	NP_542377	O43435	TBX1_HUMAN	T-box 1 isoform A	350					embryonic viscerocranium morphogenesis|heart development|parathyroid gland development|pharyngeal system development|regulation of transcription from RNA polymerase II promoter|soft palate development|thymus development	nucleus	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|breast(1)	2	Colorectal(54;0.0993)	all_lung(157;3.05e-06)				AAGCTGAGACGTCTAGGAACA	0.547000													23	137					0	0	0	0
PI4KA	5297	broad.mit.edu	37	22	21157491	21157491	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr22:21157491G>A	uc002zsz.3	-	13	1636	c.1405C>T	c.(1405-1407)CAG>TAG	p.Q469*	PI4KA_uc010gsq.1_Nonsense_Mutation_p.Q527*	NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	469					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			GTGTGGTACTGACTGTGGTAC	0.547000													14	158					0	0	0	0
P2RX6	9127	broad.mit.edu	37	22	21377467	21377467	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr22:21377467C>T	uc010gsu.1	+	6	618	c.618C>T	c.(616-618)TTC>TTT	p.F206F	P2RX6_uc002ztz.2_Silent_p.F180F|P2RX6_uc002zua.2_RNA|P2RX6_uc002zuc.1_RNA	NM_005446	NP_005437	O15547	P2RX6_HUMAN	purinergic receptor P2X6 isoform 1	206	Extracellular (Potential).				muscle contraction|protein homooligomerization	cell junction|cytoplasm|integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0						CAGTCACCTTCAGCAAGTTCA	0.572000													11	283					0	0	0	0
MYO18B	84700	broad.mit.edu	37	22	26343755	26343755	+	Silent	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr22:26343755G>C	uc003abz.1	+	36	5959	c.5709G>C	c.(5707-5709)CTG>CTC	p.L1903L	MYO18B_uc003aca.1_Silent_p.L1784L|MYO18B_uc010guy.1_Silent_p.L1785L|MYO18B_uc010guz.1_Silent_p.L1783L|MYO18B_uc011aka.1_Silent_p.L1057L|MYO18B_uc011akb.1_Silent_p.L1416L	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1903	Tail.|Potential.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						AGGATGACCTGAATGAGCTGA	0.557000													9	18					0	0	0	0
CRYBA4	1413	broad.mit.edu	37	22	27026341	27026341	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr22:27026341C>T	uc003acz.3	+	6	516	c.481C>T	c.(481-483)CAG>TAG	p.Q161*		NM_001886	NP_001877	P53673	CRBA4_HUMAN	crystallin, beta A4	161	Beta/gamma crystallin 'Greek key' 4.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens				0						CCGAGGATTTCAGTATGTGCT	0.537000													12	35					0	0	0	0
TCN2	6948	broad.mit.edu	37	22	31010483	31010483	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr22:31010483C>T	uc003aip.1	+	4	733	c.575C>T	c.(574-576)TCT>TTT	p.S192F	TCN2_uc003aiq.1_Missense_Mutation_p.S188F|TCN2_uc003air.1_Missense_Mutation_p.S165F	NM_000355	NP_000346	P20062	TCO2_HUMAN	transcobalamin II precursor	192	Cobalamin binding.				cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular space	cobalamin binding			central_nervous_system(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GGCCACCATTCTGTGGGTGAG	0.602000													9	17					0	0	0	0
FOXRED2	80020	broad.mit.edu	37	22	36886209	36886209	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr22:36886209T>C	uc003apn.3	-	8	2009	c.1901A>G	c.(1900-1902)CAC>CGC	p.H634R	FOXRED2_uc003apm.3_Missense_Mutation_p.H186R|FOXRED2_uc003apo.3_Missense_Mutation_p.H634R|FOXRED2_uc003app.3_Missense_Mutation_p.H634R	NM_024955	NP_079231	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	634					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			lung(1)|kidney(1)	2						CTCCACTCTGTGCTGCCAAAG	0.637000													12	100					0	0	0	0
MKL1	57591	broad.mit.edu	37	22	40825650	40825650	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr22:40825650G>T	uc003ayv.1	-	4	468	c.261C>A	c.(259-261)AAC>AAA	p.N87K	MKL1_uc003ayw.1_Missense_Mutation_p.N87K|MKL1_uc010gye.1_Missense_Mutation_p.N87K|MKL1_uc010gyf.1_Missense_Mutation_p.N87K	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	87	RPEL 2.|Mediates interaction with SCAI and ACTB (By similarity).				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						CAGGAAGGATGTTCTTCTCCA	0.577000			T	RBM15	acute megakaryocytic leukemia								35	14					1.99505e-19	3.91529e-19	1	0
PLXNB2	23654	broad.mit.edu	37	22	50721260	50721260	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr22:50721260C>T	uc003bkv.3	-	18	2973	c.2867G>A	c.(2866-2868)CGG>CAG	p.R956Q	PLXNB2_uc003bkt.1_5'Flank|PLXNB2_uc003bku.1_5'Flank	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	956	Extracellular (Potential).|IPT/TIG 2.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CATCTGGCCCCGTGTCGCCTG	0.672000													4	28					0	0	0	0
HACL1	26061	broad.mit.edu	37	3	15609959	15609959	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:15609959C>T	uc003caf.2	-	13	1390	c.1230G>A	c.(1228-1230)CAG>CAA	p.Q410Q	HACL1_uc011avr.1_RNA|HACL1_uc011avs.1_Silent_p.Q383Q|HACL1_uc011avt.1_Silent_p.Q350Q|HACL1_uc003cag.2_Silent_p.Q54Q|HACL1_uc011avu.1_Silent_p.Q328Q|HACL1_uc010hep.2_Silent_p.Q169Q	NM_012260	NP_036392	Q9UJ83	HACL1_HUMAN	2-hydroxyphytanoyl-CoA lyase	410	Thiamine pyrophosphate binding.				fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding				0						GAAGGTAGTTCTGAAGCACAG	0.368000													5	40					0	0	0	0
TGFBR2	7048	broad.mit.edu	37	3	30713698	30713698	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:30713698C>T	uc003ceo.2	+	4	1405	c.1023C>T	c.(1021-1023)GTC>GTT	p.V341V	TGFBR2_uc003cen.2_Silent_p.V366V	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	341	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						CGCGGCATGTCATCAGCTGGG	0.617000													52	40					0	0	0	0
MLH1	4292	broad.mit.edu	37	3	37048548	37048548	+	Silent	SNP	G	A	A	rs63750638		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:37048548G>A	uc003cgl.2	+	5	507	c.447G>A	c.(445-447)CAG>CAA	p.Q149Q	MLH1_uc011aye.1_5'UTR|MLH1_uc011ayb.1_5'UTR|MLH1_uc010hge.2_Silent_p.Q149Q|MLH1_uc003cgn.3_5'UTR|MLH1_uc011ayc.1_Silent_p.Q51Q|MLH1_uc011ayd.1_5'UTR|MLH1_uc003cgo.2_5'UTR	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	149					mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						AAGGGACCCAGATCACGGTAA	0.343000		1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				22	15					0	0	0	0
DLEC1	9940	broad.mit.edu	37	3	38081086	38081086	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:38081086G>A	uc003cho.1	+	1	391	c.370G>A	c.(370-372)GAG>AAG	p.E124K	DLEC1_uc003chp.1_Missense_Mutation_p.E124K|DLEC1_uc010hgv.1_Missense_Mutation_p.E124K	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	124					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CCGCGGCAGCGAGAATGAGCG	0.647000													23	39					0	0	0	0
TTC21A	199223	broad.mit.edu	37	3	39156090	39156090	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:39156090G>A	uc003cjc.2	+	6	750	c.573G>A	c.(571-573)ATG>ATA	p.M191I	TTC21A_uc003cja.2_Missense_Mutation_p.M191I|TTC21A_uc010hho.1_Missense_Mutation_p.M113I|TTC21A_uc003cjb.2_Missense_Mutation_p.D58N|TTC21A_uc003cje.2_Missense_Mutation_p.M191I|TTC21A_uc003cjd.2_RNA|TTC21A_uc011ayx.1_Missense_Mutation_p.M150I	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	191	TPR 4.						binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TGTACTTCATGATGCAGCAGA	0.557000													62	57					0	0	0	0
ALS2CL	259173	broad.mit.edu	37	3	46713495	46713495	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:46713495C>G	uc003cqa.1	-	24	2753	c.2563G>C	c.(2563-2565)GAG>CAG	p.E855Q	ALS2CL_uc003cpx.1_Missense_Mutation_p.E202Q|ALS2CL_uc003cpy.1_RNA|ALS2CL_uc003cpz.1_Missense_Mutation_p.E370Q|ALS2CL_uc003cqb.1_Missense_Mutation_p.E855Q|ALS2CL_uc003cqc.1_RNA	NM_147129	NP_667340	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like isoform 1	855	VPS9.				endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		TCCAGCACCTCCAGCTTCTCC	0.622000													3	50					0	0	0	0
NBEAL2	23218	broad.mit.edu	37	3	47033992	47033992	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:47033992G>A	uc003cqp.2	+	10	1239	c.1060G>A	c.(1060-1062)GAG>AAG	p.E354K	NBEAL2_uc003cqq.1_Intron|NBEAL2_uc010hjm.1_5'Flank	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	354							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		GGCGCCCCCCGAGGGGGACAG	0.637000													5	4					0	0	0	0
CCDC36	339834	broad.mit.edu	37	3	49294689	49294689	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:49294689G>C	uc003cwk.2	+	10	2146	c.1759G>C	c.(1759-1761)GAT>CAT	p.D587H	CCDC36_uc011bck.1_Missense_Mutation_p.D587H	NM_178173	NP_835467	Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	587										ovary(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		CCTGGGTTTTGATAGCAGTGA	0.478000													3	162					0	0	0	0
RBM5	10181	broad.mit.edu	37	3	50151488	50151488	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:50151488G>C	uc003cyg.2	+	19	1871	c.1723G>C	c.(1723-1725)GAA>CAA	p.E575Q	RBM5_uc011bdj.1_Missense_Mutation_p.E519Q|RBM5_uc011bdk.1_Missense_Mutation_p.E403Q|RBM5_uc003cyh.2_Missense_Mutation_p.E32Q	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5	575	Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGAAAGGAGAGAATCTGCTGC	0.423000													22	24					0	0	0	0
GRM2	2912	broad.mit.edu	37	3	51749374	51749374	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:51749374G>C	uc010hlv.2	+	4	1824	c.1585G>C	c.(1585-1587)GAG>CAG	p.E529Q	GRM2_uc003dbo.3_5'UTR|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	529	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	CCAGCCCTATGAGTACCGATT	0.612000													6	15					0	0	0	0
SFMBT1	51460	broad.mit.edu	37	3	52947576	52947576	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:52947576G>C	uc003dgf.2	-	16	2107	c.1538C>G	c.(1537-1539)TCA>TGA	p.S513*	SFMBT1_uc010hmr.2_Nonsense_Mutation_p.S460*|SFMBT1_uc003dgg.2_Nonsense_Mutation_p.S513*|SFMBT1_uc003dgh.2_Nonsense_Mutation_p.S513*	NM_001005159	NP_001005159	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	513					regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		ATATGGCCCTGAGAAGCAACG	0.403000													13	11					0	0	0	0
ERC2	26059	broad.mit.edu	37	3	55984515	55984515	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:55984515G>A	uc003dhr.1	-	13	2597	c.2341C>T	c.(2341-2343)CAG>TAG	p.Q781*	ERC2_uc003dhq.1_RNA|ERC2_uc003dht.1_Nonsense_Mutation_p.Q260*	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	781	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TCTAGTAACTGAGCATTTTTC	0.428000													10	35					0	0	0	0
COL8A1	1295	broad.mit.edu	37	3	99513335	99513335	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:99513335G>A	uc003dtg.1	+	5	835	c.590G>A	c.(589-591)GGA>GAA	p.G197E	COL8A1_uc003dth.1_Missense_Mutation_p.G197E|COL8A1_uc003dti.1_Missense_Mutation_p.G198E	NM_001850	NP_001841	P27658	CO8A1_HUMAN	alpha 1 type VIII collagen precursor	197	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII					0						GGACCACAAGGACCTCCAGGG	0.587000													5	58					0	0	0	0
BOC	91653	broad.mit.edu	37	3	112998239	112998239	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:112998239A>T	uc003dzx.2	+	12	2578	c.1957A>T	c.(1957-1959)ATT>TTT	p.I653F	BOC_uc003dzy.2_Missense_Mutation_p.I653F|BOC_uc003dzz.2_Missense_Mutation_p.I654F|BOC_uc003eab.2_Missense_Mutation_p.I354F|BOC_uc003eac.2_5'Flank	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	653	Fibronectin type-III 2.|Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			GGGAGACTGGATTCTGGCCAC	0.602000													9	47					0	0	0	0
CD80	941	broad.mit.edu	37	3	119248769	119248769	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:119248769A>T	uc003ecq.2	-	5	1111	c.716T>A	c.(715-717)TTT>TAT	p.F239Y	CD80_uc010hqt.1_Intron|CD80_uc010hqu.1_Intron	NM_005191	NP_005182	P33681	CD80_HUMAN	CD80 antigen precursor	239	Extracellular (Potential).				interspecies interaction between organisms|intracellular signal transduction|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of signal transduction|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation	intracellular	coreceptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2					Abatacept(DB01281)	GTTATCAGGAAAATGCTCTTG	0.408000													5	61					0	0	0	0
NDUFB4	4710	broad.mit.edu	37	3	120315376	120315376	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:120315376G>A	uc003edu.2	+	1	249	c.170G>A	c.(169-171)CGA>CAA	p.R57Q	NDUFB4_uc003edt.2_Missense_Mutation_p.R57Q	NM_004547	NP_004538	O95168	NDUB4_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	57					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0				GBM - Glioblastoma multiforme(114;0.14)	NADH(DB00157)	CCCAACCGCCGAGGGCTCATC	0.632000													4	17					0	0	0	0
GOLGB1	2804	broad.mit.edu	37	3	121414936	121414936	+	Silent	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:121414936T>C	uc003eei.3	-	13	4545	c.4419A>G	c.(4417-4419)GAA>GAG	p.E1473E	GOLGB1_uc010hrc.2_Silent_p.E1478E|GOLGB1_uc003eej.3_Silent_p.E1439E|GOLGB1_uc011bjm.1_Silent_p.E1359E|GOLGB1_uc010hrd.1_Silent_p.E1437E	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1473	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		CTCTACTTTCTTCTCCAATCT	0.393000													42	223					0	0	0	0
TMEM22	80723	broad.mit.edu	37	3	136573801	136573801	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:136573801C>T	uc003erf.3	+	2	713	c.499C>T	c.(499-501)CGA>TGA	p.R167*	TMEM22_uc003erg.3_Nonsense_Mutation_p.R167*|TMEM22_uc010hub.2_Nonsense_Mutation_p.R167*	NM_001097600	NP_001091069	Q8TBE7	TMM22_HUMAN	transmembrane protein 22	167	DUF6 1.					Golgi apparatus|integral to membrane				ovary(1)	1						ATACAGATTACGACTCTTCTT	0.408000													34	160					0	0	0	0
AGTR1	185	broad.mit.edu	37	3	148459339	148459339	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:148459339G>A	uc003ewg.2	+	4	963	c.517G>A	c.(517-519)GAG>AAG	p.E173K	AGTR1_uc003ewh.2_Missense_Mutation_p.E173K|AGTR1_uc003ewi.2_Missense_Mutation_p.E173K|AGTR1_uc003ewj.2_Missense_Mutation_p.E173K|AGTR1_uc003ewk.2_Missense_Mutation_p.E173K	NM_031850	NP_114038	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	173	Extracellular (Potential).				calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity				0			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	ATTTTTCATTGAGAACACCAA	0.443000													25	85					0	0	0	0
VEPH1	79674	broad.mit.edu	37	3	157146114	157146114	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:157146114G>A	uc003fbj.1	-	5	1010	c.693C>T	c.(691-693)CTC>CTT	p.L231L	VEPH1_uc003fbk.1_Silent_p.L231L|VEPH1_uc010hvu.1_Silent_p.L231L	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	231						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			TTTTTACCTCGAGTTGTTTTT	0.438000													6	69					0	0	0	0
IFT80	57560	broad.mit.edu	37	3	160099354	160099354	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:160099354G>A	uc011boy.1	-	3	629	c.196C>T	c.(196-198)CCA>TCA	p.P66S	IFT80_uc003fda.2_Intron|IFT80_uc003fdb.1_5'UTR|IFT80_uc003fdd.1_5'UTR|IFT80_uc003fde.1_5'UTR	NM_020800	NP_065851	Q9P2H3	IFT80_HUMAN	WD repeat domain 56	66						cilium axoneme|microtubule basal body				ovary(1)	1			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AAACTTTTTGGAAACCAGTGA	0.358000													9	51					0	0	0	0
ABCC5	10057	broad.mit.edu	37	3	183707045	183707045	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr3:183707045T>C	uc003fmg.2	-	3	421	c.256A>G	c.(256-258)AGT>GGT	p.S86G	ABCC5_uc011bqt.1_5'UTR|ABCC5_uc010hxl.2_Missense_Mutation_p.S86G|ABCC5_uc003fmh.2_Missense_Mutation_p.S86G|ABCC5_uc010hxm.2_RNA|ABCC5_uc010hxn.2_Missense_Mutation_p.S86G|ABCC5_uc010hxo.2_Missense_Mutation_p.S86G	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	86						integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TTCAGAGCACTCAAGCCATGA	0.473000													28	17					0	0	0	0
BOD1L	259282	broad.mit.edu	37	4	13603813	13603813	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr4:13603813T>A	uc003gmz.1	-	10	4828	c.4711A>T	c.(4711-4713)AAT>TAT	p.N1571Y	BOD1L_uc010idr.1_Missense_Mutation_p.N908Y	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1571							DNA binding			ovary(5)|breast(1)	6						AGAGGATTATTTCTGGAATGT	0.468000													5	19					0	0	0	0
GPR125	166647	broad.mit.edu	37	4	22517230	22517230	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr4:22517230C>T	uc003gqm.1	-	1	443	c.178G>A	c.(178-180)GAG>AAG	p.E60K	GPR125_uc003gqo.2_Missense_Mutation_p.E60K	NM_145290	NP_660333	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125 precursor	60	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)				ACCTTGCCCTCGGCGGCGCCC	0.572000													11	11					0	0	0	0
PDS5A	23244	broad.mit.edu	37	4	39843630	39843630	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr4:39843630C>G	uc003guv.3	-	31	4135	c.3595G>C	c.(3595-3597)GAG>CAG	p.E1199Q	PDS5A_uc010ifo.2_Missense_Mutation_p.E1159Q	NM_001100399	NP_001093869	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog	1199					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding				0						ACAGGGTTCTCTTCATTTTCA	0.343000													4	41					0	0	0	0
DCAF4L1	285429	broad.mit.edu	37	4	41984115	41984115	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr4:41984115C>T	uc003gwk.2	+	1	403	c.306C>T	c.(304-306)ATC>ATT	p.I102I		NM_001029955	NP_001025126	Q3SXM0	DC4L1_HUMAN	WD repeat domain 21B	102										skin(1)	1						ACGGCATCATCAGCCTGCGAA	0.557000													17	42					0	0	0	0
SHISA3	152573	broad.mit.edu	37	4	42403210	42403210	+	Silent	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr4:42403210C>G	uc003gwp.2	+	2	677	c.459C>G	c.(457-459)ACC>ACG	p.T153T		NM_001080505	NP_001073974	A0PJX4	SHSA3_HUMAN	shisa homolog 3 precursor	153	Cytoplasmic (Potential).				multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				ovary(1)|skin(1)	2						TGACCTCCACCAGCCCCAGGG	0.647000													30	108					0	0	0	0
CHIC2	26511	broad.mit.edu	37	4	54880271	54880271	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr4:54880271C>T	uc003haj.1	-	4	667	c.346G>A	c.(346-348)GAG>AAG	p.E116K	PDGFRA_uc003haa.2_Intron	NM_012110	NP_036242	Q9UKJ5	CHIC2_HUMAN	cysteine-rich hydrophobic domain 2	116						plasma membrane	protein binding			central_nervous_system(1)	1	all_cancers(7;0.0193)|all_neural(26;0.0209)|Lung NSC(11;0.0281)|Glioma(25;0.08)		LUSC - Lung squamous cell carcinoma(32;0.00216)			AATAACTTCTCAATCGATCTT	0.403000			T	ETV6	AML								10	19					0	0	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68925156	68925156	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr4:68925156C>G	uc003hdt.1	-	9	1095	c.1046G>C	c.(1045-1047)AGA>ACA	p.R349T	LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	349	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						GGTTTCCACTCTGGCTTGCCG	0.358000													12	21					0	0	0	0
COL25A1	84570	broad.mit.edu	37	4	109895698	109895698	+	Silent	SNP	T	C	C	rs142155024	by1000genomes	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr4:109895698T>C	uc003hze.1	-	6	987	c.456A>G	c.(454-456)AAA>AAG	p.K152K	COL25A1_uc003hzg.2_Silent_p.K152K|COL25A1_uc003hzd.2_RNA|COL25A1_uc003hzf.2_5'UTR	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	152	Extracellular (Potential).|Collagen-like 1.					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CCTTATCGCCTTTTGGACCAG	0.318000													3	121					0	0	0	0
NDST4	64579	broad.mit.edu	37	4	115769459	115769459	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr4:115769459G>C	uc003ibu.2	-	9	2531	c.1852C>G	c.(1852-1854)CCT>GCT	p.P618A	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	618	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		ATGATTGAAGGATGCATAAGA	0.308000													4	60					0	0	0	0
QRFPR	84109	broad.mit.edu	37	4	122250496	122250496	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr4:122250496C>A	uc010inj.1	-	6	1648	c.1269G>T	c.(1267-1269)GAG>GAT	p.E423D	QRFPR_uc010ink.1_RNA|QRFPR_uc003ids.2_3'UTR	NM_198179	NP_937822	Q96P65	QRFPR_HUMAN	G protein-coupled receptor 103	423	Cytoplasmic (Potential).					plasma membrane	neuropeptide Y receptor activity				0						AAGGAGAATTCTCAGCCAGTT	0.368000													23	55					1.10513e-12	2.12891e-12	1	0
HPGD	3248	broad.mit.edu	37	4	175414436	175414436	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr4:175414436C>T	uc003itu.2	-	6	718	c.528G>A	c.(526-528)GTG>GTA	p.V176V	HPGD_uc003itt.2_Silent_p.V43V|HPGD_uc003itv.2_Intron|HPGD_uc011ckf.1_Silent_p.V55V|HPGD_uc010irp.2_Silent_p.V55V|HPGD_uc010irq.2_Intron|HPGD_uc011ckg.1_Silent_p.V108V|HPGD_uc011ckh.1_Silent_p.V55V	NM_000860	NP_000851	P15428	PGDH_HUMAN	hydroxyprostaglandin dehydrogenase 15-(NAD)	176					female pregnancy|lipoxygenase pathway|negative regulation of cell cycle|parturition|prostaglandin metabolic process|transforming growth factor beta receptor signaling pathway	cytosol|nucleus	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|NAD+ binding|prostaglandin E receptor activity|protein homodimerization activity				0		Prostate(90;0.00763)|Melanoma(52;0.0179)|Renal(120;0.0376)|Breast(14;0.0991)|all_hematologic(60;0.124)|all_neural(102;0.196)		all cancers(43;2.6e-18)|Epithelial(43;4.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.23e-09)|GBM - Glioblastoma multiforme(59;0.00176)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.0253)	NADH(DB00157)	CATTCAGTCTCACACCACTGT	0.363000													9	45					0	0	0	0
ADAM29	11086	broad.mit.edu	37	4	175897135	175897135	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr4:175897135C>T	uc003iuc.2	+	5	1129	c.459C>T	c.(457-459)GAC>GAT	p.D153D	ADAM29_uc003iud.2_Silent_p.D153D|ADAM29_uc010irr.2_Silent_p.D153D|ADAM29_uc011cki.1_Silent_p.D153D	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	153					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		ACAAGATGGACAGTGAGGAGA	0.363000													19	67					0	0	0	0
SNX25	83891	broad.mit.edu	37	4	186231908	186231908	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr4:186231908C>A	uc003ixh.2	+	7	979	c.790C>A	c.(790-792)CCT>ACT	p.P264T	SNX25_uc010ish.2_Missense_Mutation_p.P35T	NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	264					cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		CCTGGGAGGCCCTGCCTATGA	0.512000													14	80					4.14922e-12	7.92009e-12	1	0
ANKRD37	353322	broad.mit.edu	37	4	186318369	186318369	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr4:186318369G>A	uc003ixm.2	+	2	331	c.93G>A	c.(91-93)AAG>AAA	p.K31K	LRP2BP_uc011ckr.1_5'Flank|ANKRD37_uc011cks.1_Silent_p.K31K	NM_181726	NP_859077	Q7Z713	ANR37_HUMAN	ankyrin repeat domain 37	31	ANK 2.					cytoplasm|nucleus					0		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;1.27e-25)|Epithelial(43;1.02e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.14e-11)|BRCA - Breast invasive adenocarcinoma(30;7.72e-05)|GBM - Glioblastoma multiforme(59;0.000118)|STAD - Stomach adenocarcinoma(60;0.000756)|LUSC - Lung squamous cell carcinoma(40;0.00902)|COAD - Colon adenocarcinoma(29;0.00939)|READ - Rectum adenocarcinoma(43;0.155)		ATCCCTGCAAGCAGTCGCCTG	0.592000													14	73					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187630110	187630110	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr4:187630110G>C	uc003izf.2	-	2	1060	c.872C>G	c.(871-873)TCT>TGT	p.S291C	FAT1_uc010iso.1_Missense_Mutation_p.S291C	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	291	Extracellular (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GATGCTTAAAGATGCTATGTC	0.488000										HNSCC(5;0.00058)			20	173					0	0	0	0
DNAH5	1767	broad.mit.edu	37	5	13901432	13901432	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr5:13901432G>A	uc003jfd.2	-	14	2023	c.1981C>T	c.(1981-1983)CGC>TGC	p.R661C		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	661	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTGTAACTGCGAATTATAGGT	0.532000									Kartagener_syndrome				16	30					0	0	0	0
CDH9	1007	broad.mit.edu	37	5	26881405	26881405	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr5:26881405G>A	uc003jgs.1	-	12	2379	c.2210C>T	c.(2209-2211)ACG>ATG	p.T737M	CDH9_uc011cnv.1_Missense_Mutation_p.T330M	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	737	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						ATAGGCATACGTTGCCAGCGA	0.423000													29	72					0	0	0	0
PRLR	5618	broad.mit.edu	37	5	35086419	35086419	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr5:35086419C>G	uc003jjm.2	-	4	624	c.94G>C	c.(94-96)GAG>CAG	p.E32Q	PRLR_uc003jjg.1_Missense_Mutation_p.E32Q|PRLR_uc003jjh.1_Missense_Mutation_p.E32Q|PRLR_uc003jji.1_Intron|PRLR_uc003jjj.1_Missense_Mutation_p.E32Q|PRLR_uc003jjk.1_Intron|PRLR_uc003jjl.3_Intron|PRLR_uc010iuw.1_5'UTR	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	32	Fibronectin type-III 1.|Extracellular (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TTAAAGATCTCAGGTTTTCCA	0.448000													16	55					0	0	0	0
PAIP1	10605	broad.mit.edu	37	5	43539127	43539127	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr5:43539127C>T	uc003job.2	-	5	992	c.745G>A	c.(745-747)GAA>AAA	p.E249K	PAIP1_uc003joa.2_Missense_Mutation_p.E170K|PAIP1_uc010ivp.2_Missense_Mutation_p.E170K|PAIP1_uc010ivo.2_Intron|PAIP1_uc003joc.2_Missense_Mutation_p.E137K	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	249	MIF4G.				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					ACTTCATATTCAGTCCGACAT	0.333000													21	54					0	0	0	0
SNX18	112574	broad.mit.edu	37	5	53814496	53814496	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr5:53814496C>T	uc003jpj.3	+	1	904	c.714C>T	c.(712-714)TCC>TCT	p.S238S	SNX18_uc011cqg.1_Silent_p.S238S|SNX18_uc003jpi.3_Silent_p.S238S	NM_052870	NP_443102	Q96RF0	SNX18_HUMAN	sorting nexin 18 isoform b	238					cell communication|endocytosis|positive regulation of GTPase activity|protein transport	endomembrane system|endosome membrane|extrinsic to internal side of plasma membrane	phosphatidylinositol binding|protein binding				0		Lung NSC(810;3.46e-05)|Breast(144;0.102)				TCGTCAAGTCCGGCGGGGAGG	0.706000													20	45					0	0	0	0
LOC441089	441089	broad.mit.edu	37	5	79647313	79647313	+	RNA	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr5:79647313G>A	uc010jaj.1	-	1		c.473C>T				NR_003665				Homo sapiens CRSP8 pseudogene (LOC441089), non-coding RNA.												0						GGTAGGACAAGAGTTGTGGGC	0.463000													5	46					0	0	0	0
ANKRD34B	340120	broad.mit.edu	37	5	79854712	79854712	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr5:79854712G>C	uc010jam.2	-	4	1477	c.1127C>G	c.(1126-1128)TCA>TGA	p.S376*	ANKRD34B_uc003kgw.2_Nonsense_Mutation_p.S376*|ANKRD34B_uc010jan.2_Nonsense_Mutation_p.S376*	NM_001004441	NP_001004441	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	376						cytoplasm|nucleus				pancreas(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		AAGGCCAGCTGAGAGCTGGGA	0.438000													6	39					0	0	0	0
TTC37	9652	broad.mit.edu	37	5	94842673	94842673	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr5:94842673G>A	uc003klb.2	-	30	3327	c.3057C>T	c.(3055-3057)TAC>TAT	p.Y1019Y		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	1019							binding			ovary(3)|pancreas(1)	4						TTGCAACATTGTAAGTATCTT	0.323000													15	32					0	0	0	0
LNPEP	4012	broad.mit.edu	37	5	96320825	96320825	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr5:96320825C>G	uc003kmv.1	+	3	1416	c.902C>G	c.(901-903)TCT>TGT	p.S301C	LNPEP_uc003kmw.1_Missense_Mutation_p.S287C	NM_005575	NP_005566	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase isoform 1	301	Extracellular (Potential).			S -> L (in Ref. 6; AA sequence).	cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		GCAGCAAGATCTGCTTTTCCT	0.303000													22	87					0	0	0	0
NRG2	9542	broad.mit.edu	37	5	139231379	139231379	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr5:139231379T>A	uc003lex.1	-	9	1807	c.1582A>T	c.(1582-1584)AGC>TGC	p.S528C	NRG2_uc003lev.1_Missense_Mutation_p.S536C|NRG2_uc003lew.1_Missense_Mutation_p.S530C|NRG2_uc003ley.1_Missense_Mutation_p.S522C	NM_004883	NP_004874	O14511	NRG2_HUMAN	neuregulin 2 isoform 1	528	Cytoplasmic (Potential).				embryo development	extracellular region|integral to membrane|plasma membrane	growth factor activity			pancreas(2)|breast(2)|ovary(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAGTCAGGCTCTCAGAACGT	0.632000													7	32					0	0	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203557	140203557	+	Missense_Mutation	SNP	C	T	T	rs140039635		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr5:140203557C>T	uc003lhl.2	+	1	2197	c.2197C>T	c.(2197-2199)CGG>TGG	p.R733W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.R733W|PCDHA5_uc003lhj.1_Missense_Mutation_p.R733W	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	733	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGTGCACACGGGGCAAGCC	0.662000													15	33					0	0	0	0
PCDHB1	29930	broad.mit.edu	37	5	140433131	140433131	+	Silent	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr5:140433131C>A	uc003lik.1	+	1	2153	c.2076C>A	c.(2074-2076)GTC>GTA	p.V692V		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	692	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AATATTTGGTCATTTCTCTGG	0.388000													22	82					1.96895e-08	3.69104e-08	1	0
PCDHGA5	56110	broad.mit.edu	37	5	140746180	140746180	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr5:140746180G>A	uc003lju.1	+	1	2283	c.2283G>A	c.(2281-2283)GCG>GCA	p.A761A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Silent_p.A761A	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	761	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCTCACCGCGGACTCGAGGA	0.592000													13	136					0	0	0	0
PCDHGB6	56100	broad.mit.edu	37	5	140789449	140789449	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr5:140789449G>A	uc003lkj.1	+	1	1680	c.1680G>A	c.(1678-1680)CCG>CCA	p.P560P	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Silent_p.P560P	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	560	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAACGCACCGCGGGTGCTGT	0.662000													6	22					0	0	0	0
SPARC	6678	broad.mit.edu	37	5	151052775	151052775	+	Silent	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr5:151052775T>C	uc003luh.2	-	3	147	c.123A>G	c.(121-123)GTA>GTG	p.V41V	GM2A_uc011dcs.1_Intron|SPARC_uc003lug.2_5'UTR|SPARC_uc003lui.2_Silent_p.V41V	NM_003118	NP_003109	P09486	SPRC_HUMAN	secreted protein, acidic, cysteine-rich	41	Asp/Glu-rich (acidic; binds calcium).				ossification|platelet activation|platelet degranulation|signal transduction	basement membrane|extracellular space|platelet alpha granule lumen	calcium ion binding|collagen binding			central_nervous_system(1)	1		Medulloblastoma(196;0.109)|all_hematologic(541;0.122)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;0.00118)	Becaplermin(DB00102)	CTCCCACAGATACCTGGAATT	0.522000													34	67					0	0	0	0
HK3	3101	broad.mit.edu	37	5	176308467	176308467	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr5:176308467G>A	uc003mfa.2	-	18	2555	c.2463C>T	c.(2461-2463)GAC>GAT	p.D821D	HK3_uc003mez.2_Silent_p.D377D	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	821	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCATCAGGGCGTCATCTGAGG	0.652000													9	17					0	0	0	0
FLT4	2324	broad.mit.edu	37	5	180057046	180057046	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr5:180057046C>A	uc003mma.3	-	5	652	c.573G>T	c.(571-573)ATG>ATT	p.M191I	FLT4_uc003mlz.3_Missense_Mutation_p.M191I|FLT4_uc003mmb.1_5'Flank|FLT4_uc011dgy.1_Missense_Mutation_p.M191I|FLT4_uc011dgz.1_Missense_Mutation_p.M191I|FLT4_uc011dha.1_Missense_Mutation_p.C175F	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	191	Ig-like C2-type 2.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TGGACACGAGCATGCCCCGCC	0.637000									Congenital_Hereditary_Lymphedema				7	29					1.58986e-06	2.95395e-06	1	0
SSR1	6745	broad.mit.edu	37	6	7301699	7301699	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr6:7301699G>T	uc003mxf.3	-	4	575	c.387C>A	c.(385-387)GAC>GAA	p.D129E	SSR1_uc003mxg.3_Intron|SSR1_uc010jny.2_Missense_Mutation_p.D129E	NM_003144	NP_003135	P43307	SSRA_HUMAN	signal sequence receptor, alpha precursor	129	Lumenal (Potential).				cotranslational protein targeting to membrane|positive regulation of cell proliferation	endoplasmic reticulum membrane|integral to membrane	signal sequence binding				0	Ovarian(93;0.0398)					AAAACTGGTAGTCCTGAGGAT	0.428000													23	57					3.7963e-18	7.40397e-18	1	0
OR10C1	442194	broad.mit.edu	37	6	29407891	29407891	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr6:29407891C>T	uc011dlp.1	+	1	99	c.99C>T	c.(97-99)ATC>ATT	p.I33I	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	33	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTCTCACTATCTACCTGCTGA	0.557000													31	59					0	0	0	0
NRM	11270	broad.mit.edu	37	6	30658649	30658649	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr6:30658649G>C	uc003nrc.2	-	1	121	c.103C>G	c.(103-105)CTT>GTT	p.L35V	KIAA1949_uc003nrb.3_5'Flank|NRM_uc003nrd.2_RNA|NRM_uc003nre.2_5'UTR	NM_007243	NP_009174	Q8IXM6	NRM_HUMAN	nurim	35	Perinuclear space (Potential).					integral to membrane|nuclear inner membrane					0						ATCCCTCCAAGAAGTGGCCGA	0.642000													21	47					0	0	0	0
CYP21A2	1589	broad.mit.edu	37	6	32007955	32007955	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr6:32007955C>T	uc003nze.1	+	7	1030	c.912C>T	c.(910-912)GCC>GCT	p.A304A	CYP21A2_uc003nzf.1_Silent_p.A274A	NM_000500	NP_000491	P08686	CP21A_HUMAN	cytochrome P450, family 21, subfamily A,	303					glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding				0						TCTCCTGGGCCGTGGTTTTTT	0.617000													30	111					0	0	0	0
FKBPL	63943	broad.mit.edu	37	6	32097359	32097359	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr6:32097359C>T	uc003nzr.2	-	2	469	c.199G>A	c.(199-201)GAA>AAA	p.E67K	ATF6B_uc003nzo.2_5'Flank|ATF6B_uc003nzn.2_5'Flank|ATF6B_uc011dpg.1_5'Flank|ATF6B_uc011dph.1_5'Flank	NM_022110	NP_071393	Q9UIM3	FKBPL_HUMAN	WAF-1/CIP1 stabilizing protein 39	67					response to radiation	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0						ACCAGTTTTTCAGCTCCTTGA	0.512000													11	66					0	0	0	0
DNAH8	1769	broad.mit.edu	37	6	38821072	38821072	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr6:38821072C>G	uc003ooe.1	+	39	5631	c.5031C>G	c.(5029-5031)ATC>ATG	p.I1677M		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TCTATCAAATCAGTGATTCAG	0.368000													19	32					0	0	0	0
BYSL	705	broad.mit.edu	37	6	41900357	41900357	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr6:41900357C>T	uc003orl.2	+	7	1563	c.1227C>T	c.(1225-1227)CCC>CCT	p.P409P		NM_004053	NP_004044	Q13895	BYST_HUMAN	bystin	409					cell adhesion|female pregnancy|ribosome biogenesis	cytoplasm|nucleolus					0	Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000473)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GGCTGCAGCCCCATCCACAGC	0.587000													12	64					0	0	0	0
SENP6	26054	broad.mit.edu	37	6	76344432	76344433	+	Nonsense_Mutation	DNP	GC	TT	TT			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr6:76344432_76344433GC>TT	uc003pid.3	+	5	982_983	c.363_364GC>TT	c.(361-366)ACGCAA>ACTTAA	p.Q122*	SENP6_uc003pie.3_Nonsense_Mutation_p.Q122*|SENP6_uc003pic.2_Nonsense_Mutation_p.Q122*|SENP6_uc003pif.1_Nonsense_Mutation_p.Q13*	NM_015571	NP_056386	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6 isoform 1	122					proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|urinary_tract(1)|ovary(1)|lung(1)|skin(1)	6		all_hematologic(105;0.189)				GTGAAAATACGCAAAATACGTC	0.322000													8	17					0	0	0	0
PREP	5550	broad.mit.edu	37	6	105816838	105816838	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr6:105816838C>A	uc003prc.2	-	6	860	c.657G>T	c.(655-657)CAG>CAT	p.Q219H		NM_002726	NP_002717	P48147	PPCE_HUMAN	prolyl endopeptidase	219					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)	TATCTTCTGACTGATCGGTTC	0.418000													23	33					5.35356e-11	1.01266e-10	1	0
FRK	2444	broad.mit.edu	37	6	116265528	116265528	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr6:116265528G>A	uc003pwi.1	-	6	1466	c.1019C>T	c.(1018-1020)TCT>TTT	p.S340F		NM_002031	NP_002022	P42685	FRK_HUMAN	fyn-related kinase	340	Protein kinase.				negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|lung(3)	6		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		GGCCATTCCAGAGGCAACCTG	0.418000													10	40					0	0	0	0
GRM1	2911	broad.mit.edu	37	6	146720758	146720758	+	Silent	SNP	C	T	T	rs148042148		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr6:146720758C>T	uc010khw.1	+	8	3053	c.2583C>T	c.(2581-2583)GGC>GGT	p.G861G	GRM1_uc010khv.1_Silent_p.G861G|GRM1_uc003qll.2_Silent_p.G861G|GRM1_uc011edz.1_Silent_p.G861G|GRM1_uc011eea.1_Silent_p.G861G	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	861	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TGCATGTTGGCGATGGCAAGC	0.517000													12	25					0	0	0	0
TAB2	23118	broad.mit.edu	37	6	149699950	149699950	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr6:149699950C>T	uc003qmj.2	+	3	1077	c.899C>T	c.(898-900)TCA>TTA	p.S300L	TAB2_uc011eec.1_Missense_Mutation_p.S268L|TAB2_uc010kia.1_Missense_Mutation_p.S300L|TAB2_uc010kib.1_Missense_Mutation_p.S300L|TAB2_uc003qmk.3_RNA	NM_015093	NP_055908	Q9NYJ8	TAB2_HUMAN	mitogen-activated protein kinase kinase kinase 7	300					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding				0						ACCATTCATTCATCTGGTAGC	0.433000													9	82					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152737810	152737810	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr6:152737810G>A	uc010kiw.2	-	41	6364	c.5762C>T	c.(5761-5763)TCT>TTT	p.S1921F	SYNE1_uc003qot.3_Missense_Mutation_p.S1928F|SYNE1_uc003qou.3_Missense_Mutation_p.S1921F|SYNE1_uc010kjb.1_Missense_Mutation_p.S1904F	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1921	Cytoplasmic (Potential).|Potential.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GACGGCAGCAGATTCTAATGC	0.453000										HNSCC(10;0.0054)			21	46					0	0	0	0
LPAL2	80350	broad.mit.edu	37	6	160899548	160899548	+	RNA	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr6:160899548G>C	uc003qtj.2	-	8		c.1337C>G			LPAL2_uc011efy.1_RNA	NR_028093				Homo sapiens cDNA FLJ43922 fis, clone TESTI4012406.												0		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.214)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)		ACCTGCTTCAGAATGAGCCTC	0.453000													9	47					0	0	0	0
PDE10A	10846	broad.mit.edu	37	6	165792780	165792780	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr6:165792780T>A	uc003qun.2	-	19	2099	c.1858A>T	c.(1858-1860)ATC>TTC	p.I620F	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.I550F|PDE10A_uc003quo.2_Missense_Mutation_p.I630F	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	620					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	GTGGCAATGATGGCTTTGCGG	0.413000													7	41					0	0	0	0
SFRP4	6424	broad.mit.edu	37	7	37956080	37956080	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr7:37956080G>A	uc003tfo.3	-	1	446	c.60C>T	c.(58-60)CGC>CGT	p.R20R		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	20	FZ.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						AGGGCGCGCCGCGCACGCCCA	0.682000													19	32					0	0	0	0
ABCA13	154664	broad.mit.edu	37	7	48318187	48318187	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr7:48318187C>G	uc003toq.2	+	18	7421	c.7396C>G	c.(7396-7398)CTA>GTA	p.L2466V	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2466					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TTCATTCCCTCTAAGAAACAG	0.358000													12	129					0	0	0	0
WBSCR17	64409	broad.mit.edu	37	7	70853278	70853278	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr7:70853278C>G	uc003tvy.2	+	3	480	c.480C>G	c.(478-480)TTC>TTG	p.F160L	WBSCR17_uc003tvz.2_5'UTR	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	160	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				TATTCATCTTCGTGAACGAGG	0.527000													6	67					0	0	0	0
PCLO	27445	broad.mit.edu	37	7	82475906	82475906	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr7:82475906T>A	uc003uhx.2	-	12	14097	c.13808A>T	c.(13807-13809)GAA>GTA	p.E4603V	PCLO_uc003uhv.2_Missense_Mutation_p.E4603V|PCLO_uc003uht.1_Missense_Mutation_p.E54V|PCLO_uc003uhu.1_Missense_Mutation_p.E33V	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4491					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTCATGAAGTTCCAGATGCTG	0.338000													19	17					0	0	0	0
RUNDC3B	154661	broad.mit.edu	37	7	87258202	87258202	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr7:87258202G>C	uc003ujb.2	+	1	474	c.63G>C	c.(61-63)AAG>AAC	p.K21N	ABCB1_uc003uiz.1_Intron|ABCB1_uc003uja.1_Intron|ABCB1_uc010lei.1_Intron|RUNDC3B_uc011khd.1_Missense_Mutation_p.K21N|RUNDC3B_uc011khe.1_Missense_Mutation_p.K21N|RUNDC3B_uc003ujc.2_Missense_Mutation_p.K21N	NM_138290	NP_612147	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B isoform a	21										skin(1)	1	Esophageal squamous(14;0.00164)					GAGGCGGCAAGAAAAGCCTGA	0.716000													4	11					0	0	0	0
CYP3A7	1551	broad.mit.edu	37	7	99306662	99306662	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr7:99306662C>T	uc003uru.2	-	11	1354	c.1249G>A	c.(1249-1251)GAA>AAA	p.E417K	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,	417					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					TCCTACCTTTCAGGGAGGAAC	0.512000													18	89					0	0	0	0
MUC17	140453	broad.mit.edu	37	7	100676630	100676630	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr7:100676630G>C	uc003uxp.1	+	3	1986	c.1933G>C	c.(1933-1935)GAG>CAG	p.E645Q	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	645	Extracellular (Potential).|8.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GGCCAGTTCTGAGGCTAGCAC	0.483000													115	469					0	0	0	0
C7orf66	154907	broad.mit.edu	37	7	108524578	108524578	+	Silent	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr7:108524578C>G	uc003vfo.2	-	1	60	c.12G>C	c.(10-12)GTG>GTC	p.V4V		NM_001024607	NP_001019778	A4D0T2	CG066_HUMAN	hypothetical protein LOC154907	4						integral to membrane				ovary(2)	2						TGGGTGTCATCACAGCCATCA	0.413000													3	54					0	0	0	0
C7orf58	79974	broad.mit.edu	37	7	120764400	120764400	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr7:120764400G>C	uc003vjq.3	+	8	1381	c.934G>C	c.(934-936)GAG>CAG	p.E312Q	C7orf58_uc003vjr.1_Missense_Mutation_p.E312Q|C7orf58_uc003vjs.3_Missense_Mutation_p.E312Q|C7orf58_uc003vjt.3_Missense_Mutation_p.E92Q|C7orf58_uc010lkk.1_Missense_Mutation_p.E92Q	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	312						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					AACATTTTTTGAGACATTCCT	0.393000													16	53					0	0	0	0
FSCN3	29999	broad.mit.edu	37	7	127240328	127240328	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr7:127240328G>A	uc003vmd.1	+	6	1591	c.1372G>A	c.(1372-1374)GAG>AAG	p.E458K	FSCN3_uc011koh.1_Missense_Mutation_p.R322Q|FSCN3_uc010llc.1_Missense_Mutation_p.R456Q	NM_020369	NP_065102	Q9NQT6	FSCN3_HUMAN	fascin 3	458						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			ovary(1)	1						CTTCTGTATCGAGCTTCAGGG	0.537000													6	59					0	0	0	0
LRGUK	136332	broad.mit.edu	37	7	133812362	133812362	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr7:133812362G>A	uc003vrm.1	+	1	258	c.242G>A	c.(241-243)GGC>GAC	p.G81D		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	81							ATP binding|kinase activity			lung(2)|skin(2)|kidney(1)	5						GAGGACCAGGGCGAGGGCGAG	0.612000													7	40					0	0	0	0
KIAA1549	57670	broad.mit.edu	37	7	138603487	138603487	+	Silent	SNP	G	A	A	rs79934303	by1000genomes	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr7:138603487G>A	uc011kql.1	-	2	934	c.885C>T	c.(883-885)GAC>GAT	p.D295D	KIAA1549_uc003vuk.3_Silent_p.D245D|KIAA1549_uc011kqj.1_Silent_p.D295D	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	295						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						TAGTAATGCCGTCGCCTAACG	0.537000			O	BRAF	pilocytic astrocytoma								16	54					0	0	0	0
PARP12	64761	broad.mit.edu	37	7	139727113	139727113	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr7:139727113G>A	uc003vvl.1	-	10	2465	c.1591C>T	c.(1591-1593)CGA>TGA	p.R531*	PARP12_uc003vvk.1_Nonsense_Mutation_p.R317*|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	531	PARP catalytic.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					TTCTGTACTCGCTCAATCTTC	0.537000													5	42					0	0	0	0
ADCK2	90956	broad.mit.edu	37	7	140373236	140373236	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr7:140373236G>T	uc003vvy.1	+	1	284	c.106G>T	c.(106-108)GAT>TAT	p.D36Y	ADCK2_uc003vvz.2_Missense_Mutation_p.D36Y	NM_052853	NP_443085	Q7Z695	ADCK2_HUMAN	aarF domain containing kinase 2	36						integral to membrane	ATP binding|protein serine/threonine kinase activity				0	Melanoma(164;0.00956)					GTGCCCTCGCGATGCCAGGCT	0.677000													6	12					0.00116845	0.00212076	1	0
KEL	3792	broad.mit.edu	37	7	142643301	142643301	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr7:142643301C>T	uc003wcb.2	-	11	1517	c.1307G>A	c.(1306-1308)CGA>CAA	p.R436Q		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	436	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					TACAGCACTTCGGGTGCTCGG	0.577000													8	11					0	0	0	0
CSMD1	64478	broad.mit.edu	37	8	3267046	3267046	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr8:3267046G>T	uc011kwk.1	-	13	2036	c.1646C>A	c.(1645-1647)ACA>AAA	p.T549K	CSMD1_uc011kwj.1_5'UTR	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	549	Extracellular (Potential).|Sushi 3.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AAAGGTGAGTGTATCTCCATG	0.527000													4	5					0.000602214	0.0010962	1	0
DEFA4	1669	broad.mit.edu	37	8	6794410	6794410	+	Missense_Mutation	SNP	G	C	C	rs61749084	byFrequency	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr8:6794410G>C	uc003wqu.1	-	2	63	c.12C>G	c.(10-12)ATC>ATG	p.I4M		NM_001925	NP_001916	P12838	DEF4_HUMAN	defensin, alpha 4 preproprotein	4					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				large_intestine(1)	1				COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		CGAGGAGGGCGATAATCCTCA	0.622000													4	9					0	0	0	0
KIF13B	23303	broad.mit.edu	37	8	28974435	28974435	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr8:28974435G>A	uc003xhh.3	-	31	3809	c.3750C>T	c.(3748-3750)ATC>ATT	p.I1250I	uc003xhi.1_Intron	NM_015254	NP_056069	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	1250					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		TCACGCGCACGATCAGGAACA	0.602000													26	63					0	0	0	0
IKBKB	3551	broad.mit.edu	37	8	42179657	42179657	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr8:42179657C>G	uc003xow.1	+	18	2001	c.1824C>G	c.(1822-1824)ATC>ATG	p.I608M	IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Missense_Mutation_p.I385M|IKBKB_uc003xox.1_Missense_Mutation_p.I329M|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Missense_Mutation_p.I606M|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Missense_Mutation_p.I549M	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	608					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	TGCGAGTGATCTATACGCAGC	0.557000													8	63					0	0	0	0
MOS	4342	broad.mit.edu	37	8	57025647	57025648	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr8:57025647_57025648GG>AA	uc011leb.1	-	1	894_895	c.894_895CC>TT	c.(892-897)TCCCTC>TCTTTC	p.L299F		NM_005372	NP_005363	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene	299	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|ovary(1)|central_nervous_system(1)	4			Epithelial(17;0.00117)|all cancers(17;0.00879)			GCAGCGGAGAGGGACGGGCGCA	0.683000													9	31					0	0	0	0
MYBL1	4603	broad.mit.edu	37	8	67514655	67514655	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr8:67514655C>T	uc003xwj.2	-	2	531	c.124G>A	c.(124-126)GAG>AAG	p.E42K	MYBL1_uc003xwl.2_Missense_Mutation_p.E42K|MYBL1_uc003xwk.2_Missense_Mutation_p.E42K	NM_001080416	NP_001073885	P10243	MYBA_HUMAN	v-myb myeloblastosis viral oncogene homolog	42	HTH myb-type 1.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)	3			Epithelial(68;0.00211)|all cancers(69;0.00726)|OV - Ovarian serous cystadenocarcinoma(28;0.00989)|BRCA - Breast invasive adenocarcinoma(89;0.0938)			ATAATTACCTCGTCCCTTGTC	0.308000													16	45					0	0	0	0
CSPP1	79848	broad.mit.edu	37	8	68007843	68007843	+	Missense_Mutation	SNP	C	T	T	rs114953032	by1000genomes	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr8:68007843C>T	uc003xxi.2	+	8	962	c.931C>T	c.(931-933)CGT>TGT	p.R311C	CSPP1_uc003xxg.1_Missense_Mutation_p.R303C|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.R276C|CSPP1_uc003xxk.2_5'UTR	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	311						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			TAATGAGGATCGTGTTTTTGA	0.373000													6	34					0	0	0	0
PRDM14	63978	broad.mit.edu	37	8	70964454	70964454	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr8:70964454G>C	uc003xym.2	-	8	1776	c.1574C>G	c.(1573-1575)TCT>TGT	p.S525C		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	525	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			GGATGCAAAAGATTTACCACA	0.517000													19	121					0	0	0	0
ZFHX4	79776	broad.mit.edu	37	8	77775694	77775694	+	Silent	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr8:77775694T>C	uc003yav.2	+	11	9996	c.9609T>C	c.(9607-9609)AAT>AAC	p.N3203N		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3199						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CATTACAGAATGCAATTGCTG	0.443000										HNSCC(33;0.089)			39	134					0	0	0	0
CNGB3	54714	broad.mit.edu	37	8	87645041	87645041	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr8:87645041A>G	uc003ydx.2	-	11	1305	c.1259T>C	c.(1258-1260)ATT>ACT	p.I420T	CNGB3_uc010maj.2_Missense_Mutation_p.I282T	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	420	Helical; Name=H5; (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						TTGAAAAACAATTTCAAATAA	0.353000													14	19					0	0	0	0
CNGB3	54714	broad.mit.edu	37	8	87738776	87738776	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr8:87738776C>T	uc003ydx.2	-	3	367	c.321G>A	c.(319-321)GGG>GGA	p.G107G		NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	107	Cytoplasmic (Potential).		G -> R (in ACHM3; uncertain pathogenicity).		signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						GACCTTCTTTCCCGGGGTCCA	0.453000													64	241					0	0	0	0
OSGIN2	734	broad.mit.edu	37	8	90937360	90937360	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr8:90937360C>T	uc003yeg.2	+	6	1464	c.1118C>T	c.(1117-1119)TCT>TTT	p.S373F	OSGIN2_uc003yeh.2_Missense_Mutation_p.S417F	NM_004337	NP_004328	Q9Y236	OSGI2_HUMAN	oxidative stress induced growth inhibitor family	373					germ cell development|meiosis						0			BRCA - Breast invasive adenocarcinoma(11;0.0344)			AATCTTTTATCTGATTATACC	0.358000													14	152					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113364752	113364752	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr8:113364752C>A	uc003ynu.2	-	39	6307	c.6148G>T	c.(6148-6150)GAT>TAT	p.D2050Y	CSMD3_uc003yns.2_Missense_Mutation_p.D1252Y|CSMD3_uc003ynt.2_Missense_Mutation_p.D2010Y|CSMD3_uc011lhx.1_Missense_Mutation_p.D1946Y	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2050	Extracellular (Potential).|Sushi 11.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGACAGGAATCCAAACCAATT	0.318000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			10	70					2.17888e-05	4.02451e-05	1	0
ZFAT	57623	broad.mit.edu	37	8	135612760	135612760	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr8:135612760C>T	uc003yup.2	-	7	2569	c.2394G>A	c.(2392-2394)CTG>CTA	p.L798L	ZFAT_uc003yun.2_Silent_p.L786L|ZFAT_uc003yuo.2_Silent_p.L786L|ZFAT_uc010meh.2_Silent_p.L786L|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Silent_p.L786L|ZFAT_uc010mej.2_Silent_p.L736L|ZFAT_uc003yur.2_Silent_p.L786L|ZFATAS_uc003yus.1_RNA	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	798	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			TGGGACACTTCAGCAAGATGT	0.438000													26	109					0	0	0	0
RHPN1	114822	broad.mit.edu	37	8	144464817	144464817	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr8:144464817C>T	uc003yyb.2	+	15	2142	c.2009C>T	c.(2008-2010)CCG>CTG	p.P670L		NM_052924	NP_443156	Q8TCX5	RHPN1_HUMAN	rhophilin 1	695					signal transduction	intracellular				large_intestine(1)	1	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			CCAGGGTGGCCGTGAGGGCCA	0.687000													16	14					0	0	0	0
PLEC	5339	broad.mit.edu	37	8	144996395	144996395	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr8:144996395C>G	uc003zaf.1	-	32	8175	c.8005G>C	c.(8005-8007)GAG>CAG	p.E2669Q	PLEC_uc003zab.1_Missense_Mutation_p.E2532Q|PLEC_uc003zac.1_Missense_Mutation_p.E2536Q|PLEC_uc003zad.2_Missense_Mutation_p.E2532Q|PLEC_uc003zae.1_Missense_Mutation_p.E2500Q|PLEC_uc003zag.1_Missense_Mutation_p.E2510Q|PLEC_uc003zah.2_Missense_Mutation_p.E2518Q|PLEC_uc003zaj.2_Missense_Mutation_p.E2559Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2669	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						tgctgctCCTCACGCAGCTGC	0.517000													3	12					0	0	0	0
SLC39A4	55630	broad.mit.edu	37	8	145640760	145640760	+	Missense_Mutation	SNP	G	T	T	rs141890870	byFrequency	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr8:145640760G>T	uc003zcq.2	-	3	618	c.518C>A	c.(517-519)GCG>GAG	p.A173E	SLC39A4_uc003zcm.1_5'Flank|SLC39A4_uc003zcn.2_5'Flank|SLC39A4_uc003zco.2_Splice_Site|SLC39A4_uc003zcp.2_Missense_Mutation_p.A148E	NM_130849	NP_570901	Q6P5W5	S39A4_HUMAN	solute carrier family 39 (zinc transporter),	173	Extracellular (Potential).					cytoplasmic membrane-bounded vesicle|integral to membrane|recycling endosome membrane	zinc ion transmembrane transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;1.12e-40)|all cancers(56;8.17e-36)|BRCA - Breast invasive adenocarcinoma(115;0.0407)|Colorectal(110;0.055)			CGGAGCCCCCGCCCCCACCGC	0.682000													7	12					2.7689e-08	5.1752e-08	1	0
PSIP1	11168	broad.mit.edu	37	9	15469058	15469058	+	Splice_Site	SNP	T	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr9:15469058T>C	uc003zlv.3	-	13	1435	c.1105_splice	c.e13-1	p.D369_splice	PSIP1_uc003zlw.3_Splice_Site_p.D369_splice	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2						initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		GTTCACATCCTTCATGACAAA	0.353000													11	18					0	0	0	0
DCAF12	25853	broad.mit.edu	37	9	34098412	34098412	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr9:34098412G>C	uc003ztt.2	-	5	1047	c.705C>G	c.(703-705)ATC>ATG	p.I235M		NM_015397	NP_056212	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	235						centrosome|CUL4 RING ubiquitin ligase complex					0						CCTTGTGAGTGATGTGTGCAT	0.483000													7	108					0	0	0	0
C9orf79	286234	broad.mit.edu	37	9	90502856	90502856	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr9:90502856A>G	uc004app.3	+	4	3489	c.3454A>G	c.(3454-3456)ACC>GCC	p.T1152A		NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	1152						integral to membrane				ovary(3)	3						CCCTCTGTCCACCTCCCAGAG	0.642000													8	32					0	0	0	0
KIAA1529	57653	broad.mit.edu	37	9	100136864	100136864	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr9:100136864G>A	uc011lut.1	+	47	5962	c.5189G>A	c.(5188-5190)CGA>CAA	p.R1730Q	KIAA1529_uc004axe.1_Missense_Mutation_p.R1536Q|KIAA1529_uc004axg.1_Missense_Mutation_p.R1591Q|KIAA1529_uc004axh.1_RNA|KIAA1529_uc011luw.1_Missense_Mutation_p.R684Q	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				ATGCTCATACGAAGGAAACTC	0.507000													4	22					0	0	0	0
SVEP1	79987	broad.mit.edu	37	9	113169482	113169482	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr9:113169482C>G	uc010mtz.2	-	38	8735	c.8398G>C	c.(8398-8400)GAG>CAG	p.E2800Q	SVEP1_uc010mty.2_Missense_Mutation_p.E726Q	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2800	Sushi 23.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GGGTCACACTCATAGTACAAC	0.483000													76	52					0	0	0	0
LAMC3	10319	broad.mit.edu	37	9	133957539	133957539	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr9:133957539G>C	uc004caa.1	+	24	4119	c.4021G>C	c.(4021-4023)GAT>CAT	p.D1341H	LAMC3_uc010mze.1_Missense_Mutation_p.D57H	NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	1341	Domain II and I.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		TCTGCTGGCTGATCTGGAAGG	0.617000													13	5					0	0	0	0
C9orf96	169436	broad.mit.edu	37	9	136253248	136253248	+	Silent	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr9:136253248C>G	uc004cdk.2	+	5	373	c.312C>G	c.(310-312)CTC>CTG	p.L104L	C9orf96_uc004cdl.2_RNA	NM_153710	NP_714921	Q8NE28	SGK71_HUMAN	hypothetical protein LOC169436	104	Protein kinase.						ATP binding|protein kinase activity			stomach(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		CTCTGTACCTCTGCCTGGTGA	0.572000													12	55					0	0	0	0
PHPT1	29085	broad.mit.edu	37	9	139744530	139744530	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr9:139744530G>A	uc004cjp.2	+	3	848	c.226G>A	c.(226-228)GGC>AGC	p.G76S	PHPT1_uc011mei.1_Missense_Mutation_p.G76S|PHPT1_uc004cjq.3_Missense_Mutation_p.G76S|MAMDC4_uc004cjs.2_5'Flank|MAMDC4_uc011mej.1_5'Flank	NM_014172	NP_054891	Q9NRX4	PHP14_HUMAN	phosphohistidine phosphatase 1 isoform 3	76						cytosol	phosphohistidine phosphatase activity|phosphoprotein phosphatase activity				0	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		GTGTCTGGGCGGCGGGCGCAT	0.647000													47	20					0	0	0	0
C8G	733	broad.mit.edu	37	9	139840948	139840948	+	Silent	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr9:139840948G>C	uc004cka.2	+	5	561	c.486G>C	c.(484-486)CTG>CTC	p.L162L	FBXW5_uc004cjx.2_5'Flank|FBXW5_uc004cjy.2_5'Flank|FBXW5_uc004cjz.2_5'Flank	NM_000606	NP_000597	P07360	CO8G_HUMAN	complement component 8, gamma polypeptide	162					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex	retinol binding|transporter activity				0	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.88e-06)|Epithelial(140;0.000107)		ACTCGGTCCTGAGTGGGTTTG	0.657000													3	19					0	0	0	0
RNF208	727800	broad.mit.edu	37	9	140115259	140115259	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr9:140115259C>T	uc004clz.1	-	1	517	c.406G>A	c.(406-408)GCG>ACG	p.A136T		NM_031297	NP_112587	Q9H0X6	RN208_HUMAN	ring finger protein 208	136							zinc ion binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		TCGCCTGCCGCCGCCGAAGAA	0.672000													23	11					0	0	0	0
ASMTL	8623	broad.mit.edu	37	X	1554652	1554652	+	Splice_Site	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chrX:1554652C>T	uc004cpx.1	-	4	385	c.274_splice	c.e4-1	p.T92_splice	ASMTL_uc011mhe.1_Intron|ASMTL_uc004cpy.1_Splice_Site_p.T76_splice|ASMTL_uc011mhf.1_Splice_Site_p.T34_splice	NM_004192	NP_004183	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like						melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CCCCGACTGTCTGTGAGAGGA	0.587000													11	69					0	0	0	0
CNKSR2	22866	broad.mit.edu	37	X	21545080	21545080	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chrX:21545080C>T	uc004czx.1	+	10	1089	c.1053C>T	c.(1051-1053)CTC>CTT	p.L351L	CNKSR2_uc004czw.2_Silent_p.L351L|CNKSR2_uc011mjn.1_Silent_p.L302L|CNKSR2_uc011mjo.1_Silent_p.L351L|CNKSR2_uc004czy.2_5'UTR	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	351	DUF1170.				regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						TCCAGGATCTCTACATTCCCC	0.483000													16	137					0	0	0	0
MID1IP1	58526	broad.mit.edu	37	X	38664680	38664680	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chrX:38664680C>G	uc004dei.3	+	3	905	c.481C>G	c.(481-483)CTC>GTC	p.L161V	MID1IP1_uc010ngz.2_Missense_Mutation_p.L161V|MID1IP1_uc004dej.3_Missense_Mutation_p.L161V	NM_001098790	NP_001092260	Q9NPA3	M1IP1_HUMAN	MID1 interacting G12-like protein	161					lipid biosynthetic process|negative regulation of microtubule depolymerization|positive regulation of fatty acid biosynthetic process|positive regulation of ligase activity|protein polymerization	cytosol|microtubule|nucleus					0						GCTCTCGAAACTCACGCGCAA	0.627000													11	7					0	0	0	0
ATP6AP2	10159	broad.mit.edu	37	X	40456555	40456555	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chrX:40456555G>C	uc004det.2	+	4	457	c.355G>C	c.(355-357)GAG>CAG	p.E119Q	ATP6AP2_uc010nhc.2_RNA|ATP6AP2_uc011mkl.1_Missense_Mutation_p.E43Q|ATP6AP2_uc011mkm.1_Intron|ATP6AP2_uc011mkn.1_Intron|ATP6AP2_uc004deu.1_5'Flank	NM_005765	NP_005756	O75787	RENR_HUMAN	ATPase, H+ transporting, lysosomal accessory	119	Extracellular (Potential).				angiotensin maturation|positive regulation of transforming growth factor-beta1 production|regulation of MAPKKK cascade	external side of plasma membrane|integral to membrane	protein binding|receptor activity				0						CTTATTTTCTGAGGAAACTCC	0.323000													8	21					0	0	0	0
UBA1	7317	broad.mit.edu	37	X	47074277	47074277	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chrX:47074277C>T	uc004dhj.3	+	26	3277	c.3126C>T	c.(3124-3126)GAC>GAT	p.D1042D	UBA1_uc004dhk.3_Silent_p.D1042D|UBA1_uc004dhm.2_Silent_p.D490D	NM_153280	NP_695012	P22314	UBA1_HUMAN	ubiquitin-activating enzyme E1	1042					cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			ovary(1)	1						GCTGTAACGACGAGAGCGGCG	0.627000													23	16					0	0	0	0
UBQLN2	29978	broad.mit.edu	37	X	56591223	56591223	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chrX:56591223A>T	uc004dus.2	+	1	1152	c.917A>T	c.(916-918)CAG>CTG	p.Q306L	UBQLN2_uc011moq.1_Missense_Mutation_p.Q306L	NM_013444	NP_038472	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	306						cytoplasm|nucleus|plasma membrane	binding			ovary(1)|skin(1)	2						GAAGGTACGCAGCCTTCCCGC	0.562000													11	3					0	0	0	0
ARR3	407	broad.mit.edu	37	X	69489243	69489243	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chrX:69489243A>C	uc004dyb.2	+	2	76	c.8A>C	c.(7-9)AAG>ACG	p.K3T	ARR3_uc004dya.2_Missense_Mutation_p.K3T	NM_004312	NP_004303	P36575	ARRC_HUMAN	arrestin 3, retinal (X-arrestin)	3					signal transduction|visual perception	cytoplasm|soluble fraction				large_intestine(2)|ovary(2)	4						AACATGTCCAAGTAAGAATTC	0.423000													11	5					0	0	0	0
PGAM4	441531	broad.mit.edu	37	X	77224532	77224532	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chrX:77224532C>G	uc004ecy.1	-	1	604	c.604G>C	c.(604-606)GAA>CAA	p.E202Q	ATP7A_uc004ecw.2_Intron|ATP7A_uc004ecx.3_Intron	NM_001029891	NP_001025062	Q8N0Y7	PGAM4_HUMAN	bisphosphoglycerate mutase 4	202					glycolysis		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity				0						ATAGCCTCTTCAGAGAGACCC	0.512000													4	179					0	0	0	0
NAP1L3	4675	broad.mit.edu	37	X	92927456	92927456	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chrX:92927456C>G	uc004efq.2	-	1	1153	c.848G>C	c.(847-849)AGA>ACA	p.R283T	FAM133A_uc004efr.1_5'Flank	NM_004538	NP_004529	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	283					nucleosome assembly	chromatin assembly complex				ovary(1)|skin(1)	2						CTCAGGAACTCTTTTATGAGT	0.453000													3	87					0	0	0	0
TCEAL4	79921	broad.mit.edu	37	X	102842017	102842017	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chrX:102842017C>T	uc004ekl.2	+	3	707	c.414C>T	c.(412-414)CTC>CTT	p.L138L	TCEAL4_uc004ekn.2_Silent_p.L138L|TCEAL4_uc004ekm.2_Silent_p.L138L|TCEAL4_uc004eko.2_Silent_p.L138L	NM_024863	NP_079139	Q96EI5	TCAL4_HUMAN	transcription elongation factor A (SII)-like 4	138					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						CTCATTACCTCAAGGAGTATA	0.433000													11	117					0	0	0	0
PLP1	5354	broad.mit.edu	37	X	103041526	103041526	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chrX:103041526C>T	uc010nov.2	+	4	604	c.324C>T	c.(322-324)ATC>ATT	p.I108I	RAB9B_uc004eli.1_Intron|PLP1_uc004elk.2_Silent_p.I108I|PLP1_uc004elj.2_Silent_p.I108I|PLP1_uc011msf.1_Silent_p.I53I|PLP1_uc010now.1_Silent_p.I112I|PLP1_uc010nox.2_Silent_p.I62I	NM_001128834	NP_001122306	P60201	MYPR_HUMAN	proteolipid protein 1 isoform 1	108	Cytoplasmic (Probable).				cell death|synaptic transmission	integral to membrane				ovary(1)	1						AGACCACCATCTGCGGCAAGG	0.582000													12	110					0	0	0	0
SERPINA7	6906	broad.mit.edu	37	X	105280474	105280474	+	Silent	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chrX:105280474G>A	uc004eme.1	-	1	592	c.576C>T	c.(574-576)CTC>CTT	p.L192L	SERPINA7_uc010npd.2_Silent_p.L192L|SERPINA7_uc010npe.1_Silent_p.L192L	NM_000354	NP_000345	P05543	THBG_HUMAN	serine (or cysteine) proteinase inhibitor, clade	192					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity				0					Levothyroxine(DB00451)|Liothyronine(DB00279)	TGTTTGGCTTGAGGTCTTGAA	0.418000													18	103					0	0	0	0
CHRDL1	91851	broad.mit.edu	37	X	109922601	109922601	+	Silent	SNP	C	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chrX:109922601C>T	uc004eou.3	-	11	1558	c.1209G>A	c.(1207-1209)GAG>GAA	p.E403E	CHRDL1_uc004eov.2_Silent_p.E392E|CHRDL1_uc004eow.2_Silent_p.E401E|CHRDL1_uc010nps.2_Silent_p.E402E|CHRDL1_uc004eot.2_Silent_p.E322E|CHRDL1_uc011mss.1_Silent_p.E317E	NM_001143981	NP_001137453	Q9BU40	CRDL1_HUMAN	chordin-like 1 isoform 1 precursor	395					BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region					0						AGTGAGGAAGCTCCTCAAACA	0.453000													45	15					0	0	0	0
ATP2B3	492	broad.mit.edu	37	X	152845713	152845713	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chrX:152845713C>G	uc004fht.1	+	20	3746	c.3620C>G	c.(3619-3621)TCC>TGC	p.S1207C	ATP2B3_uc004fhs.1_3'UTR|ATP2B3_uc010nuf.1_Missense_Mutation_p.S344C|ATP2B3_uc004fhu.1_Missense_Mutation_p.S159C	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	1207	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTGTTTTCCTCCAGTCCCGGG	0.473000													3	75					0	0	0	0
KDM5D	8284	broad.mit.edu	37	Y	21877710	21877710	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chrY:21877710G>A	uc004fug.2	-	16	2500	c.2212C>T	c.(2212-2214)CGG>TGG	p.R738W	KDM5D_uc011naz.1_Missense_Mutation_p.R769W|KDM5D_uc010nwy.2_Missense_Mutation_p.R681W|KDM5D_uc011nba.1_Missense_Mutation_p.R738W|KDM5D_uc004fuf.2_5'Flank	NM_004653	NP_004644	Q9BY66	KDM5D_HUMAN	jumonji, AT rich interactive domain 1D isoform	738					chromatin modification|spermatogenesis	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1					Vitamin C(DB00126)	CATGCTCACCGGAGGTACTGT	0.552000													67	9					0	0	0	0
NSUN4	387338	broad.mit.edu	37	1	46826430	46826430	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:46826430delA	uc001cpr.1	+	5	917	c.808delA	c.(808-810)AACfs	p.N270fs	NSUN4_uc010omc.1_Frame_Shift_Del_p.N221fs|NSUN4_uc009vyf.1_Frame_Shift_Del_p.N119fs|NSUN4_uc009vyg.1_Frame_Shift_Del_p.N221fs|NSUN4_uc001cpt.1_RNA|NSUN4_uc001cps.1_RNA	NM_199044	NP_950245	Q96CB9	NSUN4_HUMAN	NOL1/NOP2/Sun domain family 4 protein	270							methyltransferase activity				0	Acute lymphoblastic leukemia(166;0.155)					TGAGGAGGAGAACAACATCTT	0.473													---	---	---							
LOC200030	200030	broad.mit.edu	37	1	148349431	148349432	+	5'Flank	INS	-	G	G	rs67020224		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:148349431_148349432insG	uc001eqf.2	-						LOC200030_uc001eqe.2_5'Flank|LOC200030_uc001eqg.2_5'Flank|NBPF14_uc009wkf.1_5'Flank|uc001erd.3_5'Flank|uc001erc.3_5'Flank|uc010paj.1_5'Flank|uc010pav.1_5'Flank|uc010paw.1_5'Flank	NM_017940	NP_060410	Q86T75	NBPFB_HUMAN	hypothetical protein LOC55672							cytoplasm					0						GGGCTGACACTGGGGGGCCAGA	0.559													---	---	---							
NELL1	4745	broad.mit.edu	37	11	21592401	21592402	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr11:21592401_21592402insA	uc001mqe.2	+	18	2225_2226	c.2072_2073insA	c.(2071-2073)ACAfs	p.T691fs	NELL1_uc001mqf.2_Frame_Shift_Ins_p.T644fs|NELL1_uc009yid.2_Frame_Shift_Ins_p.T719fs|NELL1_uc010rdo.1_Frame_Shift_Ins_p.T634fs|NELL1_uc010rdp.1_Frame_Shift_Ins_p.T404fs|NELL1_uc001mqh.2_Frame_Shift_Ins_p.T236fs	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	691					cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						ACCAGAGTCACAAGTCAATGTT	0.470													---	---	---							
Unknown	0	broad.mit.edu	37	11	45777181	45777182	+	IGR	INS	-	AGGCAG	AGGCAG	rs141710688		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr11:45777181_45777182insAGGCAG								CHST1 (90009 upstream) : DKFZp779M0652 (15801 downstream)																							ggtagagacccaggcagaggca	0.233													---	---	---							
MS4A6E	245802	broad.mit.edu	37	11	60107412	60107418	+	Frame_Shift_Del	DEL	GGAAACA	-	-			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr11:60107412_60107418delGGAAACA	uc001npd.2	+	3	442_448	c.428_434delGGAAACA	c.(427-435)TGGAAACAGfs	p.W143fs		NM_139249	NP_640342	Q96DS6	M4A6E_HUMAN	membrane-spanning 4-domains, subfamily A, member	143_145	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						GTGCTGCAGTGGAAACAGACTGTCTGA	0.478													---	---	---							
Unknown	0	broad.mit.edu	37	12	124719586	124719594	+	IGR	DEL	CACCACCAT	-	-	rs141799019	by1000genomes	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:124719586_124719594delCACCACCAT								ZNF664 (219619 upstream) : FAM101A (54116 downstream)																							tcaccatcaccaccaccatcatcaccatc	0.000													---	---	---							
ACIN1	22985	broad.mit.edu	37	14	23528491	23528491	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:23528491delC	uc001wit.3	-	19	4220	c.3892delG	c.(3892-3894)GACfs	p.D1298fs	CDH24_uc001wil.2_5'Flank|CDH24_uc010akf.2_5'Flank|CDH24_uc001win.3_5'Flank|ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Frame_Shift_Del_p.D540fs|ACIN1_uc001wiq.3_Frame_Shift_Del_p.D540fs|ACIN1_uc001wir.3_Frame_Shift_Del_p.D571fs|ACIN1_uc001wis.3_Frame_Shift_Del_p.D979fs|ACIN1_uc010akg.2_Frame_Shift_Del_p.D1285fs	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1298	Arg/Asp/Glu/Lys-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		TCCCccctgtcccgctccctt	0.478											OREG0022595	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---							
Unknown	0	broad.mit.edu	37	16	33547973	33547973	+	IGR	DEL	C	-	-			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr16:33547973delC								SLC6A10P (651510 upstream) : MIR1826 (417535 downstream)																							CCTGAGTGAACATGACATTAA	0.294													---	---	---							
Unknown	0	broad.mit.edu	37	2	201967218	201967218	+	IGR	DEL	G	-	-			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:201967218delG								NDUFB3 (16747 upstream) : CFLAR (13598 downstream)																							aaaaaaaaaagaaTTTGTTCT	0.229													---	---	---							
MC3R	4159	broad.mit.edu	37	20	54823685	54823686	+	5'Flank	DEL	TC	-	-			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr20:54823685_54823686delTC	uc002xxb.2	+							NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor						activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			tgtgtgtatgtctctctctctc	0.208													---	---	---							
TCF20	6942	broad.mit.edu	37	22	42611473	42611474	+	5'Flank	INS	-	T	T			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:42611473_42611474insT	uc003bcj.1	-						TCF20_uc003bck.1_5'Flank|TCF20_uc003bnt.2_5'Flank	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						TTGAAtttctattttttttttt	0.193													---	---	---							
TFG	10342	broad.mit.edu	37	3	100463757	100463758	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:100463757_100463758insA	uc003due.2	+	7	1251_1252	c.802_803insA	c.(802-804)TATfs	p.Y268fs	TFG_uc003duf.2_Frame_Shift_Ins_p.Y268fs|TFG_uc003dug.2_Frame_Shift_Ins_p.Y264fs|TFG_uc003duh.2_Frame_Shift_Ins_p.Y264fs|TFG_uc003dui.2_Frame_Shift_Ins_p.Y268fs	NM_006070	NP_006061	Q92734	TFG_HUMAN	TRK-fused	268					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm	signal transducer activity		TFG/ALK(7)	haematopoietic_and_lymphoid_tissue(7)|lung(2)|large_intestine(1)|prostate(1)	11						GCCTCAACAGTATGGTATTCAG	0.455			T	NTRK1|ALK	papillary thyroid|ALCL|NSCLC								---	---	---							
Unknown	0	broad.mit.edu	37	4	57829485	57829485	+	IGR	DEL	A	-	-			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:57829485delA								REST (31146 upstream) : C4orf14 (32 downstream)																							tcagtctcagaaaaaaaaaaa	0.104													---	---	---							
POLR2B	5431	broad.mit.edu	37	4	57896492	57896492	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:57896492delT	uc003hcl.1	+	24	3405	c.3362delT	c.(3361-3363)CTTfs	p.L1121fs	POLR2B_uc011cae.1_Frame_Shift_Del_p.L1114fs|POLR2B_uc011caf.1_Frame_Shift_Del_p.L1046fs|POLR2B_uc003hcm.1_Frame_Shift_Del_p.L614fs	NM_000938	NP_000929	P30876	RPB2_HUMAN	DNA directed RNA polymerase II polypeptide B	1121	C4-type.				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(2)	2	Glioma(25;0.08)|all_neural(26;0.181)					GTTTGCAATCTTTGTGGAATA	0.448													---	---	---							
FAT1	2195	broad.mit.edu	37	4	187628386	187628386	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:187628386delC	uc003izf.2	-	2	2784	c.2596delG	c.(2596-2598)GACfs	p.D866fs	FAT1_uc010iso.1_Frame_Shift_Del_p.D866fs	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	866	Extracellular (Potential).|Cadherin 7.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GAAAATGTGTCTGTGTCTGTA	0.493										HNSCC(5;0.00058)			---	---	---							
Unknown	0	broad.mit.edu	37	7	2290782	2290783	+	IGR	DEL	TT	-	-			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:2290782_2290783delTT								NUDT1 (2 upstream) : SNX8 (3858 downstream)																							CTAGCGGTGGtttttttttttt	0.257													---	---	---							
NELL1	4745	broad.mit.edu	37	11	21592401	21592402	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr11:21592401_21592402insA	uc001mqe.2	+	18	2225_2226	c.2072_2073insA	c.(2071-2073)ACAfs	p.T691fs	NELL1_uc001mqf.2_Frame_Shift_Ins_p.T644fs|NELL1_uc009yid.2_Frame_Shift_Ins_p.T719fs|NELL1_uc010rdo.1_Frame_Shift_Ins_p.T634fs|NELL1_uc010rdp.1_Frame_Shift_Ins_p.T404fs|NELL1_uc001mqh.2_Frame_Shift_Ins_p.T236fs	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	691					cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						ACCAGAGTCACAAGTCAATGTT	0.470													---	---	---							
ACIN1	22985	broad.mit.edu	37	14	23528491	23528491	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr14:23528491delC	uc001wit.3	-	19	4220	c.3892delG	c.(3892-3894)GACfs	p.D1298fs	CDH24_uc001wil.2_5'Flank|CDH24_uc010akf.2_5'Flank|CDH24_uc001win.3_5'Flank|ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Frame_Shift_Del_p.D540fs|ACIN1_uc001wiq.3_Frame_Shift_Del_p.D540fs|ACIN1_uc001wir.3_Frame_Shift_Del_p.D571fs|ACIN1_uc001wis.3_Frame_Shift_Del_p.D979fs|ACIN1_uc010akg.2_Frame_Shift_Del_p.D1285fs	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1298	Arg/Asp/Glu/Lys-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		TCCCccctgtcccgctccctt	0.478											OREG0022595	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---							
RPTOR	57521	broad.mit.edu	37	17	78516456	78516456	+	5'Flank	DEL	A	-	-	rs143567101		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr17:78516456delA	uc002jyt.1	+						RPTOR_uc002jys.2_5'Flank|RPTOR_uc010wuf.1_5'Flank|RPTOR_uc010wug.1_5'Flank|RPTOR_uc002jyr.1_5'Flank	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1						cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						TAAAAACTGCAAAAAAAaaaa	0.224													---	---	---							
Unknown	0	broad.mit.edu	37	2	133020743	133020744	+	IGR	INS	-	T	T	rs137914230		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr2:133020743_133020744insT								NCRNA00164 (5201 upstream) : GPR39 (153403 downstream)																							TTAGATAGCTCTTTATTGTCAT	0.327													---	---	---							
Unknown	0	broad.mit.edu	37	4	57829485	57829485	+	IGR	DEL	A	-	-			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr4:57829485delA								REST (31146 upstream) : C4orf14 (32 downstream)																							tcagtctcagaaaaaaaaaaa	0.104													---	---	---							
POLR2B	5431	broad.mit.edu	37	4	57896492	57896492	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr4:57896492delT	uc003hcl.1	+	24	3405	c.3362delT	c.(3361-3363)CTTfs	p.L1121fs	POLR2B_uc011cae.1_Frame_Shift_Del_p.L1114fs|POLR2B_uc011caf.1_Frame_Shift_Del_p.L1046fs|POLR2B_uc003hcm.1_Frame_Shift_Del_p.L614fs	NM_000938	NP_000929	P30876	RPB2_HUMAN	DNA directed RNA polymerase II polypeptide B	1121	C4-type.				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(2)	2	Glioma(25;0.08)|all_neural(26;0.181)					GTTTGCAATCTTTGTGGAATA	0.448													---	---	---							
Unknown	0	broad.mit.edu	37	8	49297743	49297743	+	IGR	DEL	A	-	-	rs140564135		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr8:49297743delA								UBE2V2 (323291 upstream) : EFCAB1 (325608 downstream)																							CGGAGGCAGGAAAAAAAAAAG	0.428													---	---	---							
FOXE1	2304	broad.mit.edu	37	9	100616701	100616706	+	In_Frame_Del	DEL	GCCGCC	-	-			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr9:100616701_100616706delGCCGCC	uc004axu.2	+	1	1165_1170	c.505_510delGCCGCC	c.(505-510)GCCGCCdel	p.AA177del		NM_004473	NP_004464	O00358	FOXE1_HUMAN	forkhead box E1	177_178	Ala-rich.				cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		Acute lymphoblastic leukemia(62;0.158)				Ggctgccgcagccgccgccgccgccg	0.573													---	---	---							
