Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RERE	473	broad.mit.edu	37	1	8674682	8674682	+	Missense_Mutation	SNP	A	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr1:8674682A>T	uc001ape.2	-	5	1270	c.460T>A	c.(460-462)TCT>ACT	p.S154T	RERE_uc001apf.2_Missense_Mutation_p.S154T|RERE_uc001aph.1_Missense_Mutation_p.S154T	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	154	BAH.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		ACCGGCAGAGAGCATGCTGGG	0.498													50	106					0	0	0.014410	0	0
TNFRSF1B	7133	broad.mit.edu	37	1	12266986	12266986	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr1:12266986C>T	uc001att.2	+	10	1384	c.1295C>T	c.(1294-1296)TCA>TTA	p.S432L	TNFRSF1B_uc001atu.2_Missense_Mutation_p.S237L|TNFRSF1B_uc009vnk.2_RNA	NM_001066	NP_001057	P20333	TNR1B_HUMAN	tumor necrosis factor receptor 2 precursor	432	Cytoplasmic (Potential).				apoptosis	extracellular region|integral to membrane|membrane raft|plasma membrane	tumor necrosis factor receptor activity			liver(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.72e-05)|all_lung(284;9.92e-05)|Renal(390;0.000147)|Colorectal(325;0.000584)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;5.52e-07)|COAD - Colon adenocarcinoma(227;0.000345)|BRCA - Breast invasive adenocarcinoma(304;0.000353)|Kidney(185;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00302)|STAD - Stomach adenocarcinoma(313;0.00815)|READ - Rectum adenocarcinoma(331;0.0284)	Etanercept(DB00005)|Infliximab(DB00065)	GCCTTTCGGTCACAGCTGGAG	0.622													31	70					0	0	0.009535	0	0
AGMAT	79814	broad.mit.edu	37	1	15909721	15909721	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr1:15909721T>A	uc001awv.1	-	2	585	c.442A>T	c.(442-444)ATT>TTT	p.I148F	DNAJC16_uc001awu.2_Intron	NM_024758	NP_079034	Q9BSE5	SPEB_HUMAN	agmatine ureohydrolase (agmatinase) precursor	148					putrescine biosynthetic process|spermidine biosynthetic process	mitochondrion	agmatinase activity|metal ion binding			skin(1)	1		Breast(348;0.000207)|Colorectal(325;0.000258)|Lung NSC(340;0.000359)|all_lung(284;0.000486)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.93e-07)|COAD - Colon adenocarcinoma(227;3.91e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000121)|KIRC - Kidney renal clear cell carcinoma(229;0.00257)|STAD - Stomach adenocarcinoma(313;0.00734)|READ - Rectum adenocarcinoma(331;0.0649)		GCTGCTACAATTTTCTCATAG	0.502													19	29					0	0	0.012319	0	0
SLC5A9	200010	broad.mit.edu	37	1	48713171	48713171	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr1:48713171C>T	uc001cro.2	+	14	2054	c.2002C>T	c.(2002-2004)CTT>TTT	p.L668F	SLC5A9_uc001crn.2_Missense_Mutation_p.L693F|SLC5A9_uc010omt.1_Missense_Mutation_p.L682F|SLC5A9_uc001crp.2_Missense_Mutation_p.L335F|SLC5A9_uc010omu.1_Missense_Mutation_p.L335F|SLC5A9_uc009vyt.1_RNA	NM_001011547	NP_001011547	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/glucose	668	Helical; (Potential).					integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			ovary(3)	3						CAATGCTGTCCTTTTGCTGGC	0.527													31	72					0	0	0.013726	0	0
ZYG11B	79699	broad.mit.edu	37	1	53287171	53287171	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr1:53287171A>G	uc001cuj.2	+	14	2300	c.2105A>G	c.(2104-2106)AAA>AGA	p.K702R	ZYG11B_uc010onj.1_Missense_Mutation_p.K623R|ZYG11B_uc009vzh.2_Missense_Mutation_p.K124R	NM_024646	NP_078922	Q9C0D3	ZY11B_HUMAN	zyg-11 homolog B	702							protein binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						TACAACATCAAAGATCATGAA	0.418													16	52					0	0	0.004990	0	0
USP24	23358	broad.mit.edu	37	1	55612677	55612677	+	Silent	SNP	A	G	G			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr1:55612677A>G	uc001cyg.3	-	16	1695	c.1695T>C	c.(1693-1695)TAT>TAC	p.Y565Y		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	725					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						TCCAGCCCAGATACAGAGTAG	0.393													18	29					0	0	0.007413	0	0
INADL	10207	broad.mit.edu	37	1	62365295	62365295	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr1:62365295C>T	uc001dab.2	+	23	3286	c.3172C>T	c.(3172-3174)CCA>TCA	p.P1058S	INADL_uc009waf.1_Missense_Mutation_p.P1058S|INADL_uc001daa.2_Missense_Mutation_p.P1058S|INADL_uc001dad.3_Missense_Mutation_p.P755S|INADL_uc001dac.2_RNA	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	1058					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						AGAAGAAACTCCAAATTTTAG	0.398													64	134					0	0	0.014410	0	0
HIST2H2BE	8349	broad.mit.edu	37	1	149858178	149858178	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr1:149858178C>T	uc001etc.2	-	1	55	c.13G>A	c.(13-15)GCA>ACA	p.A5T	HIST2H2AC_uc001etd.2_5'Flank	NM_003528	NP_003519	Q16778	H2B2E_HUMAN	histone cluster 2, H2be	5				A -> S (in Ref. 7; AAH98112/AAH98289).	defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			GCGGATTTTGCCGGTTCAGGC	0.507													4	70					0	0	0.009096	0	0
TCHH	7062	broad.mit.edu	37	1	152082279	152082279	+	Silent	SNP	C	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr1:152082279C>T	uc001ezp.2	-	2	3414	c.3414G>A	c.(3412-3414)AGG>AGA	p.R1138R	TCHH_uc009wne.1_Silent_p.R1138R	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1138	4-8.|10 X 30 AA tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			cccgatattgcctctccagct	0.234													35	85					0	0	0.004289	0	0
KCNN3	3782	broad.mit.edu	37	1	154841688	154841688	+	Silent	SNP	G	A	A			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr1:154841688G>A	uc001ffp.2	-	1	1067	c.753C>T	c.(751-753)AGC>AGT	p.S251S	KCNN3_uc009wox.1_Silent_p.S251S	NM_002249	NP_002240	Q9UGI6	KCNN3_HUMAN	small conductance calcium-activated potassium	256						integral to membrane	calmodulin binding			lung(1)	1	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			AGGTGGTGCTGCTGGCGGTGG	0.567													35	63					0	0	0.005524	0	0
EFNA1	1942	broad.mit.edu	37	1	155104075	155104075	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr1:155104075A>G	uc001fhh.2	+	2	458	c.353A>G	c.(352-354)AAG>AGG	p.K118R	EFNA1_uc001fhi.2_Missense_Mutation_p.K118R|EFNA1_uc009wpd.1_5'Flank	NM_004428	NP_004419	P20827	EFNA1_HUMAN	ephrin A1 isoform a precursor	118					angiogenesis|aortic valve morphogenesis|cell migration|cell-cell signaling|endocardial cushion to mesenchymal transition involved in heart valve formation|ephrin receptor signaling pathway|mitral valve morphogenesis|negative regulation of epithelial to mesenchymal transition|negative regulation of transcription from RNA polymerase II promoter|positive regulation of peptidyl-tyrosine phosphorylation|regulation of cell adhesion mediated by integrin|substrate adhesion-dependent cell spreading	extracellular region|integral to plasma membrane	ephrin receptor binding				0	all_epithelial(22;4.71e-30)|all_lung(78;3.15e-27)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;2.28e-10)|all cancers(21;6.16e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000395)|LUSC - Lung squamous cell carcinoma(543;0.193)			ACCCTGGGCAAGGAGTTCAAA	0.527													9	30					0	0	0.006214	0	0
PTCHD3	374308	broad.mit.edu	37	10	27687708	27687708	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr10:27687708A>G	uc001itu.2	-	4	1937	c.1819T>C	c.(1819-1821)TTT>CTT	p.F607L		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	607	Helical; (Potential).				spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						ACATATATAAAGACTACAAAA	0.383													57	29					0	0	0.014410	0	0
NCOA4	8031	broad.mit.edu	37	10	51585156	51585156	+	Missense_Mutation	SNP	G	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr10:51585156G>T	uc001jis.3	+	8	1458	c.1255G>T	c.(1255-1257)GAT>TAT	p.D419Y	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron|NCOA4_uc009xon.2_Missense_Mutation_p.D435Y|NCOA4_uc010qhd.1_Missense_Mutation_p.D435Y|NCOA4_uc010qhe.1_Missense_Mutation_p.D319Y|NCOA4_uc010qhf.1_Missense_Mutation_p.D253Y|NCOA4_uc001jit.2_Missense_Mutation_p.D419Y|NCOA4_uc009xoo.2_Missense_Mutation_p.D419Y	NM_001145263	NP_001138735	Q13772	NCOA4_HUMAN	nuclear receptor coactivator 4 isoform 3	419					androgen receptor signaling pathway|male gonad development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	androgen receptor binding|transcription coactivator activity			central_nervous_system(1)|kidney(1)	2						GTGTGTGTGTGATGAGAATTG	0.483			T	RET	papillary thyroid 								63	33					9.53978e-28	1.14477e-27	0.014410	1	0
SLC29A3	55315	broad.mit.edu	37	10	73111339	73111339	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr10:73111339T>A	uc001jrr.3	+	4	461	c.404T>A	c.(403-405)GTC>GAC	p.V135D	SLC29A3_uc001jrs.3_Missense_Mutation_p.V135D|SLC29A3_uc010qjq.1_5'UTR|SLC29A3_uc001jrt.3_Intron|SLC29A3_uc001jru.3_Intron	NM_018344	NP_060814	Q9BZD2	S29A3_HUMAN	solute carrier family 29 (nucleoside	135	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|late endosome membrane|lysosomal membrane	nucleoside transmembrane transporter activity				0						CACATCCGTGTCCTGGCCTCA	0.602													4	71					0	0	0.009096	0	0
WAPAL	23063	broad.mit.edu	37	10	88259986	88259986	+	Missense_Mutation	SNP	C	A	A			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr10:88259986C>A	uc001kdo.2	-	3	1456	c.1014G>T	c.(1012-1014)AAG>AAT	p.K338N	WAPAL_uc001kdn.2_Missense_Mutation_p.K381N|WAPAL_uc009xsw.2_Missense_Mutation_p.K338N	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	338	Mediates interaction with the cohesin complex.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						CACCCCCTTTCTTTGCCTGAT	0.448													101	42					6.16109e-32	7.47638e-32	0.014410	1	0
PAPSS2	9060	broad.mit.edu	37	10	89503313	89503313	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr10:89503313C>T	uc001kex.2	+	10	1654	c.1391C>T	c.(1390-1392)GCT>GTT	p.A464V	PAPSS2_uc001kew.2_Missense_Mutation_p.A469V	NM_004670	NP_004661	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	464	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|skin(1)	2		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		CAGCACGCGGCTGTGCTCGAG	0.587													43	36					0	0	0.010771	0	0
OR52K1	390036	broad.mit.edu	37	11	4510932	4510932	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr11:4510932C>T	uc001lza.1	+	1	802	c.802C>T	c.(802-804)CGC>TGC	p.R268C		NM_001005171	NP_001005171	Q8NGK4	O52K1_HUMAN	olfactory receptor, family 52, subfamily K,	268	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.76e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0836)|LUSC - Lung squamous cell carcinoma(625;0.192)		CCGTGTAGCCCGCCATGCTGC	0.507													59	136					0	0	0.014410	0	0
USP47	55031	broad.mit.edu	37	11	11942036	11942036	+	Missense_Mutation	SNP	G	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr11:11942036G>T	uc001mjq.1	+	11	2036	c.1273G>T	c.(1273-1275)GAT>TAT	p.D425Y	USP47_uc001mjr.2_Missense_Mutation_p.D337Y|USP47_uc001mjs.2_Missense_Mutation_p.D405Y	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	425					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		TGATGTTGAAGATGAGGTAAA	0.303													21	49					1.01871e-10	1.18302e-10	0.008871	1	0
DDB1	1642	broad.mit.edu	37	11	61081866	61081866	+	Silent	SNP	G	A	A			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr11:61081866G>A	uc001nrc.3	-	13	1729	c.1503C>T	c.(1501-1503)GCC>GCT	p.A501A	DDB1_uc010rle.1_Intron|DDB1_uc010rlf.1_Silent_p.A501A|DDB1_uc010rlg.1_RNA	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	501	Interaction with CDT1.|Interaction with CUL4A.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						TATTGCAGGAGGCCACACTGA	0.532								NER					4	202					0	0	0.009096	0	0
SLC25A45	283130	broad.mit.edu	37	11	65144060	65144060	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr11:65144060T>C	uc001odp.1	-	6	1107	c.685A>G	c.(685-687)ATG>GTG	p.M229V	SLC25A45_uc009yqi.1_Missense_Mutation_p.M167V|SLC25A45_uc001odq.1_Missense_Mutation_p.M205V|SLC25A45_uc001odr.1_Missense_Mutation_p.M229V|SLC25A45_uc001ods.1_Missense_Mutation_p.M187V|SLC25A45_uc001odt.1_Missense_Mutation_p.M187V	NM_001077241	NP_001070709	Q8N413	S2545_HUMAN	solute carrier family 25, member 45 isoform b	229	Solcar 3.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						TCCATCTGCATCCGGGACTTG	0.617													29	78					0	0	0.009535	0	0
RELA	5970	broad.mit.edu	37	11	65423175	65423175	+	Silent	SNP	A	G	G			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr11:65423175A>G	uc001ofg.2	-	10	1157	c.1017T>C	c.(1015-1017)GCT>GCC	p.A339A	RELA_uc001ofh.2_Silent_p.A336A|RELA_uc010ron.1_Silent_p.A350A|RELA_uc009yqr.2_Silent_p.A286A|RELA_uc001ofe.2_Silent_p.A339A|RELA_uc001off.2_Silent_p.A339A|RELA_uc009yqs.1_RNA	NM_021975	NP_068810	Q04206	TF65_HUMAN	v-rel reticuloendotheliosis viral oncogene	339					anti-apoptosis|cellular defense response|cytokine-mediated signaling pathway|defense response to virus|inflammatory response|innate immune response|interspecies interaction between organisms|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of inflammatory response|response to interleukin-1|response to UV-B|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|transcription factor complex	activating transcription factor binding|chromatin binding|identical protein binding|NF-kappaB binding|phosphate binding|protein kinase binding|protein N-terminus binding|repressing transcription factor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding			lung(3)|ovary(1)	4						TGGGGACAGAAGCTGAGCTGC	0.537													13	43					0	0	0.003163	0	0
ANO1	55107	broad.mit.edu	37	11	69951883	69951883	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr11:69951883C>T	uc001opj.2	+	5	1041	c.736C>T	c.(736-738)CGG>TGG	p.R246W	ANO1_uc001opk.1_Missense_Mutation_p.R218W|ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_5'Flank	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	246	Cytoplasmic (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						CAGCAAAACCCGGAGCACGAT	0.488													14	27					0	0	0.002450	0	0
ZC3H12C	85463	broad.mit.edu	37	11	110007683	110007683	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr11:110007683T>C	uc009yxw.2	+	2	368	c.317T>C	c.(316-318)ATT>ACT	p.I106T	ZC3H12C_uc010rwc.1_Missense_Mutation_p.I107T|ZC3H12C_uc010rwd.1_Missense_Mutation_p.I107T|ZC3H12C_uc001pkr.3_Missense_Mutation_p.I75T|ZC3H12C_uc001pkq.2_Missense_Mutation_p.I75T	NM_033390	NP_203748	Q9C0D7	ZC12C_HUMAN	zinc finger CCCH-type containing 12C	106							endonuclease activity|nucleic acid binding|zinc ion binding				0		all_cancers(61;3.24e-13)|all_epithelial(67;1.27e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.72e-06)|BRCA - Breast invasive adenocarcinoma(274;1.17e-05)|all cancers(92;9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0279)		TTGGGTAGCATTTCAGTAGAG	0.448													14	12					0	0	0.001855	0	0
DRD2	1813	broad.mit.edu	37	11	113295344	113295344	+	Silent	SNP	A	G	G			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr11:113295344A>G	uc001pnz.2	-	1	351	c.30T>C	c.(28-30)GAT>GAC	p.D10D	DRD2_uc010rwv.1_Silent_p.D10D|DRD2_uc001poa.3_Silent_p.D10D|DRD2_uc001pob.3_Silent_p.D10D|DRD2_uc009yyr.1_Silent_p.D10D	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	10	Extracellular (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	CCAGATCATCATCATACCAGG	0.587													26	65					0	0	0.003954	0	0
FAM113B	91523	broad.mit.edu	37	12	47628909	47628909	+	Silent	SNP	G	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr12:47628909G>T	uc001rpn.2	+	4	794	c.63G>T	c.(61-63)CTG>CTT	p.L21L	FAM113B_uc010slj.1_Intron|FAM113B_uc001rpq.2_Silent_p.L21L	NM_138371	NP_612380	Q96HM7	F113B_HUMAN	hypothetical protein LOC91523	21							hydrolase activity			skin(3)|ovary(2)	5	Renal(347;0.138)|Lung SC(27;0.192)					TGGTCATCCTGGGGGACTCTG	0.602													21	41					1.28384e-07	1.47505e-07	0.012319	1	0
AQP2	359	broad.mit.edu	37	12	50344816	50344816	+	Missense_Mutation	SNP	A	C	C	rs104894331		TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr12:50344816A>C	uc001rvn.2	+	1	293	c.203A>C	c.(202-204)AAC>ACC	p.N68T		NM_000486	NP_000477	P41181	AQP2_HUMAN	aquaporin 2	68	Cytoplasmic (Potential).|NPA 1.		N -> S (in ANDI).		cellular response to copper ion|cellular response to mercury ion|excretion	apical plasma membrane|integral to membrane|transport vesicle membrane	glycerol transmembrane transporter activity|water channel activity			ovary(2)	2						GCCCACATCAACCCTGCCGTG	0.662													8	39					0	0	0.003163	0	0
TMEM120B	144404	broad.mit.edu	37	12	122190050	122190050	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr12:122190050G>A	uc001ubc.3	+	5	526	c.382G>A	c.(382-384)GAA>AAA	p.E128K	TMEM120B_uc009zxh.2_Missense_Mutation_p.E128K	NM_001080825	NP_001074294	A0PK00	T120B_HUMAN	transmembrane protein 120B	128						integral to membrane					0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;5.75e-05)|Epithelial(86;0.000128)|BRCA - Breast invasive adenocarcinoma(302;0.238)		CTACAAGGACGAATATGAGAA	0.577													35	64					0	0	0.004878	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102500785	102500785	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr14:102500785A>G	uc001yks.2	+	56	10914	c.10750A>G	c.(10750-10752)AAT>GAT	p.N3584D		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	3584	AAA 5 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						GAAACGATTCAATAGGTATGA	0.473													34	76					0	0	0.003755	0	0
CALML4	91860	broad.mit.edu	37	15	68489823	68489823	+	Missense_Mutation	SNP	G	A	A	rs149339094	by1000genomes	TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr15:68489823G>A	uc002arb.2	-	4	1182	c.448C>T	c.(448-450)CGG>TGG	p.R150W	CALML4_uc002arc.2_Missense_Mutation_p.R103W|CALML4_uc002ard.2_RNA|CALML4_uc002are.2_RNA|CALML4_uc010bhz.2_Intron	NM_033429	NP_219501	Q96GE6	CALL4_HUMAN	calmodulin-like 4 isoform 1	150	EF-hand 3.						calcium ion binding				0						AGTTTTGACCGCAGGTCGGAC	0.507													38	79					0	0	0.007835	0	0
NTRK3	4916	broad.mit.edu	37	15	88679229	88679229	+	Missense_Mutation	SNP	G	C	C			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr15:88679229G>C	uc002bme.1	-	8	970	c.808C>G	c.(808-810)CTG>GTG	p.L270V	NTRK3_uc002bmh.2_Missense_Mutation_p.L270V|NTRK3_uc002bmf.1_Missense_Mutation_p.L270V|NTRK3_uc010upl.1_Missense_Mutation_p.L172V|NTRK3_uc010bnh.1_Missense_Mutation_p.L270V|NTRK3_uc002bmg.2_Missense_Mutation_p.L270V	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	270	Ig-like C2-type 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.L270M(1)	ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			ACATTCACCAGCGTCAAGTTG	0.478			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			36	79					0	0	0.005524	0	0
ACAN	176	broad.mit.edu	37	15	89398462	89398462	+	Silent	SNP	C	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr15:89398462C>T	uc010upo.1	+	12	3020	c.2646C>T	c.(2644-2646)TTC>TTT	p.F882F	ACAN_uc010upp.1_Silent_p.F882F|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	882					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			ACCTTGACTTCAGTGGGCAGC	0.597													18	45					0	0	0.007413	0	0
RHCG	51458	broad.mit.edu	37	15	90026327	90026327	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr15:90026327T>C	uc002bnz.2	-	3	517	c.493A>G	c.(493-495)AAT>GAT	p.N165D	RHCG_uc002boa.2_RNA|RHCG_uc010bnq.1_Missense_Mutation_p.N49D	NM_016321	NP_057405	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	165	Helical; (Potential).				amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			kidney(1)	1	Lung NSC(78;0.0237)|all_lung(78;0.0478)					ATGAACTCATTCACAGCGAAG	0.537													26	40					0	0	0.005443	0	0
PRSS22	64063	broad.mit.edu	37	16	2905588	2905589	+	Missense_Mutation	DNP	GC	AT	AT			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr16:2905588_2905589GC>AT	uc002cry.1	-	4	611_612	c.545_546GC>AT	c.(544-546)AGC>AAT	p.S182N	PRSS22_uc002crz.1_Intron	NM_022119	NP_071402	Q9GZN4	BSSP4_HUMAN	protease, serine, 22 precursor	182	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)	1						CATCTTGGATGCTCCCCCAGCC	0.589													51	46					0	0	0.004672	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319584	21319584	+	Silent	SNP	C	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr17:21319584C>T	uc002gyv.1	+	3	1635	c.930C>T	c.(928-930)ACC>ACT	p.T310T		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	310	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	CCATGACCACCCAGGCCCGCA	0.607										Prostate(3;0.18)			9	195					0	0	0.006214	0	0
SSH2	85464	broad.mit.edu	37	17	27975326	27975326	+	Missense_Mutation	SNP	C	A	A			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr17:27975326C>A	uc002heo.1	-	13	1182	c.1182G>T	c.(1180-1182)ATG>ATT	p.M394I	SSH2_uc010wbh.1_Missense_Mutation_p.M421I|SSH2_uc002hep.1_Missense_Mutation_p.M394I	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	394	Tyrosine-protein phosphatase.				actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						GACTCACCCCCATTTTGCAGT	0.443													41	33					1.47197e-15	1.72796e-15	0.007835	1	0
WIPF2	147179	broad.mit.edu	37	17	38416825	38416825	+	Silent	SNP	G	A	A			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr17:38416825G>A	uc002hug.1	+	3	342	c.102G>A	c.(100-102)CAG>CAA	p.Q34Q	WIPF2_uc010cwv.1_Silent_p.Q34Q|WIPF2_uc002huh.1_5'UTR|WIPF2_uc010cww.1_5'UTR|WIPF2_uc002hui.1_Silent_p.Q34Q|WIPF2_uc010cwx.1_Silent_p.Q34Q|WIPF2_uc010cwy.1_Silent_p.Q34Q	NM_133264	NP_573571	Q8TF74	WIPF2_HUMAN	WIRE protein	34						cytoplasm|cytoskeleton	actin binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						GAGATGAGCAGCGGGGTCGAG	0.463										HNSCC(43;0.11)			34	109					0	0	0.003755	0	0
FAM59A	64762	broad.mit.edu	37	18	29867256	29867256	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr18:29867256A>G	uc002kxl.2	-	4	1360	c.1304T>C	c.(1303-1305)TTC>TCC	p.F435S	FAM59A_uc002kxk.1_Missense_Mutation_p.F435S	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	435										ovary(1)|skin(1)	2						AGCTTCTGGGAAAAGGTAGTC	0.557													57	113					0	0	0.014410	0	0
MBD1	4152	broad.mit.edu	37	18	47800703	47800703	+	Silent	SNP	C	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr18:47800703C>T	uc010dow.1	-	11	1436	c.999G>A	c.(997-999)CGG>CGA	p.R333R	MBD1_uc002lef.2_Intron|MBD1_uc002leg.2_Silent_p.R283R|MBD1_uc010xdi.1_Silent_p.R384R|MBD1_uc002leh.3_Intron|MBD1_uc002len.2_Silent_p.R333R|MBD1_uc002lei.3_Silent_p.R333R|MBD1_uc002lej.3_Intron|MBD1_uc002lek.3_Silent_p.R284R|MBD1_uc002lel.3_Silent_p.R310R|MBD1_uc002lem.3_Silent_p.R333R|MBD1_uc010xdj.1_Intron|MBD1_uc010xdk.1_Silent_p.R358R|MBD1_uc010dox.1_Silent_p.R310R|MBD1_uc002leo.2_Silent_p.R333R	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1	333	CXXC-type 3.				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						TGCGGTTCTGCCGGCGGTTCG	0.642													3	45					0	0	0.004672	0	0
ZNF516	9658	broad.mit.edu	37	18	74154041	74154041	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr18:74154041C>T	uc010dqx.1	-	2	1205	c.970G>A	c.(970-972)GAG>AAG	p.E324K	ZNF516_uc002lme.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	324					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		ATCACCTCCTCCTGGACCACG	0.602													19	50					0	0	0.012319	0	0
CD209	30835	broad.mit.edu	37	19	7810714	7810714	+	Silent	SNP	G	A	A			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr19:7810714G>A	uc002mht.2	-	4	505	c.438C>T	c.(436-438)ATC>ATT	p.I146I	CD209_uc010xju.1_Intron|CD209_uc010dvp.2_Silent_p.I122I|CD209_uc002mhr.2_Silent_p.I122I|CD209_uc002mhs.2_Silent_p.I122I|CD209_uc002mhu.2_Silent_p.I146I|CD209_uc010dvq.2_Silent_p.I146I|CD209_uc002mhq.2_Silent_p.I146I|CD209_uc002mhv.2_Silent_p.I122I|CD209_uc002mhx.2_Silent_p.I102I|CD209_uc002mhw.2_Silent_p.I102I|CD209_uc010dvr.2_Intron	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	146	Extracellular (Probable).|7 X approximate tandem repeats.|3.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						GCTCCTGGTAGATCTCCTGCA	0.547													63	139					0	0	0.014410	0	0
BRD4	23476	broad.mit.edu	37	19	15350519	15350519	+	Silent	SNP	C	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr19:15350519C>T	uc002nar.2	-	16	3618	c.3396G>A	c.(3394-3396)GAG>GAA	p.E1132E		NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	1132					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			GCTTGGGGGGCTCCGGCCGCA	0.711			T	NUT|C15orf55	lethal midline carcinoma of young people								19	36					0	0	0.003954	0	0
FCGBP	8857	broad.mit.edu	37	19	40419757	40419757	+	Silent	SNP	A	G	G			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr19:40419757A>G	uc002omp.3	-	6	3245	c.3237T>C	c.(3235-3237)CAT>CAC	p.H1079H		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	1079	VWFD 2.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CCAGCTTGCTATGGCACTCCC	0.642													38	102					0	0	0.006230	0	0
HRC	3270	broad.mit.edu	37	19	49658077	49658077	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr19:49658077C>G	uc002pmv.2	-	1	605	c.418G>C	c.(418-420)GAA>CAA	p.E140Q	TRPM4_uc002pmw.2_5'Flank|TRPM4_uc010emu.2_5'Flank|TRPM4_uc010yak.1_5'Flank|TRPM4_uc002pmx.2_5'Flank|TRPM4_uc010emv.2_5'Flank|TRPM4_uc010yal.1_5'Flank	NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	140	4 X tandem repeats, acidic.|6 X approximate tandem repeats.|2-2.				muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		TCCGTGTCTTCACTCCCGTGG	0.597													30	70					0	0	0.009535	0	0
VN1R2	317701	broad.mit.edu	37	19	53762787	53762787	+	Nonsense_Mutation	SNP	C	T	T	rs150108993		TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr19:53762787C>T	uc002qbi.2	+	1	1243	c.1159C>T	c.(1159-1161)CGA>TGA	p.R387*		NM_173856	NP_776255	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	387	Cytoplasmic (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0				GBM - Glioblastoma multiforme(134;0.00301)		AAGAAATAGACGATTCTTTCA	0.433													30	91					0	0	0.008361	0	0
LRPPRC	10128	broad.mit.edu	37	2	44139638	44139638	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr2:44139638A>G	uc002rtr.2	-	30	3266	c.3208T>C	c.(3208-3210)TAC>CAC	p.Y1070H	LRPPRC_uc010yob.1_Missense_Mutation_p.Y970H	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	1070	PPR 16.				mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AGATTGCTGTAGGTTTCAGCA	0.313													31	48					0	0	0.007291	0	0
MTHFD2	10797	broad.mit.edu	37	2	74441208	74441208	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr2:74441208G>A	uc002skk.2	+	8	971	c.892G>A	c.(892-894)GTC>ATC	p.V298I	SLC4A5_uc002skl.2_Intron|MTHFD2_uc002skj.2_Missense_Mutation_p.V196I|MTHFD2_uc010yro.1_Missense_Mutation_p.V196I|MTHFD2_uc010ffb.2_Missense_Mutation_p.V215I|MTHFD2_uc010yrp.1_Missense_Mutation_p.V134I	NM_006636	NP_006627	P13995	MTDC_HUMAN	methylenetetrahydrofolate dehydrogenase 2	298					folic acid-containing compound biosynthetic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	magnesium ion binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|phosphate binding|protein binding				0					NADH(DB00157)|Tetrahydrofolic acid(DB00116)	CTATGTAGGAGTCAGACAAAA	0.398													58	136					0	0	0.014410	0	0
SEMA4F	10505	broad.mit.edu	37	2	74883759	74883759	+	Missense_Mutation	SNP	C	G	G	rs140925977		TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr2:74883759C>G	uc002sna.1	+	2	355	c.244C>G	c.(244-246)CGG>GGG	p.R82G	SEMA4F_uc010ysb.1_Missense_Mutation_p.R82G|SEMA4F_uc010ffq.1_Missense_Mutation_p.R82G|SEMA4F_uc010ffr.1_5'UTR|SEMA4F_uc002snb.1_5'UTR|SEMA4F_uc002snc.1_Missense_Mutation_p.R82G	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	82	Sema.|Extracellular (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TGTTGGCGCCCGGGACACCAT	0.562													35	83					0	0	0.003755	0	0
IL1RL2	8808	broad.mit.edu	37	2	102849533	102849533	+	Nonsense_Mutation	SNP	C	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr2:102849533C>T	uc002tbs.2	+	10	1372	c.1246C>T	c.(1246-1248)CAA>TAA	p.Q416*	IL1RL2_uc002tbt.2_Nonsense_Mutation_p.Q298*	NM_003854	NP_003845	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2 precursor	416	TIR.|Cytoplasmic (Potential).				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			ovary(2)	2						GTTGGAGAGACAATGTGGATA	0.453													31	87					0	0	0.013726	0	0
IL1RN	3557	broad.mit.edu	37	2	113885204	113885204	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr2:113885204G>A	uc002tjb.2	+	1	67	c.3G>A	c.(1-3)ATG>ATA	p.M1I	IL1RN_uc002tix.1_Intron|IL1RN_uc002tiy.2_Intron|IL1RN_uc002tiz.2_Intron|IL1RN_uc002tja.2_Intron	NM_173842	NP_776214	P18510	IL1RA_HUMAN	interleukin 1 receptor antagonist isoform 1	1					immune response|inflammatory response|response to glucocorticoid stimulus	centrosome|extracellular space|nucleus|plasma membrane	cytokine activity|interleukin-1 receptor antagonist activity			skin(2)	2					Anakinra(DB00026)	GTCACAGAATGGAAATCTGCA	0.532									Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of				12	36					0	0	0.010729	0	0
PSMD14	10213	broad.mit.edu	37	2	162227815	162227815	+	Silent	SNP	T	C	C			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr2:162227815T>C	uc002ubu.2	+	7	911	c.444T>C	c.(442-444)ATT>ATC	p.I148I		NM_005805	NP_005796	O00487	PSDE_HUMAN	proteasome 26S subunit, non-ATPase 14	148					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K63-linked deubiquitination|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of proteasomal protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	endopeptidase activator activity|metal ion binding|metallopeptidase activity|proteasome binding|ubiquitin thiolesterase activity			breast(1)	1						TGGATCCCATTCAGAGTGTAA	0.408													3	15					0	0	0.009096	0	0
NBEAL1	65065	broad.mit.edu	37	2	204039877	204039877	+	Missense_Mutation	SNP	A	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr2:204039877A>T	uc002uzt.3	+	41	6577	c.6244A>T	c.(6244-6246)AAT>TAT	p.N2082Y	NBEAL1_uc002uzs.3_Missense_Mutation_p.N792Y	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	2082	BEACH.						binding			ovary(1)|skin(1)	2						CAGATATGAAAATTTTGAGGA	0.333													21	45					0	0	0.003330	0	0
GIGYF2	26058	broad.mit.edu	37	2	233660917	233660917	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr2:233660917A>G	uc002vti.3	+	16	1962	c.1625A>G	c.(1624-1626)CAG>CGG	p.Q542R	GIGYF2_uc010zmj.1_Missense_Mutation_p.Q542R|GIGYF2_uc002vtg.2_Missense_Mutation_p.Q536R|GIGYF2_uc002vtj.3_Missense_Mutation_p.Q563R|GIGYF2_uc002vtk.3_Missense_Mutation_p.Q542R|GIGYF2_uc002vth.3_Missense_Mutation_p.Q536R|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc010zml.1_Missense_Mutation_p.Q373R	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	542	GYF.				cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		AAAGATCCTCAGGGAGAAATT	0.378													30	86					0	0	0.009535	0	0
FAM182B	728882	broad.mit.edu	37	20	25848643	25848643	+	RNA	SNP	C	T	T	rs6107089		TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr20:25848643C>T	uc002wvd.1	-	1		c.144G>A								Homo sapiens cDNA FLJ30282 fis, clone BRACE2002803.												0						ctgcttcccccggactccgcc	0													3	9					0	0	0.004672	0	0
MOCS3	27304	broad.mit.edu	37	20	49576203	49576203	+	Missense_Mutation	SNP	T	G	G			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr20:49576203T>G	uc002xvy.1	+	1	841	c.824T>G	c.(823-825)TTG>TGG	p.L275W	DPM1_uc002xvw.1_5'Flank|DPM1_uc002xvx.1_5'Flank	NM_014484	NP_055299	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	275					enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			skin(2)|ovary(1)	3						AGTGGCAGCTTGTTGCTCTTT	0.632													61	54					0	0	0.014410	0	0
NFATC2	4773	broad.mit.edu	37	20	50092014	50092014	+	Missense_Mutation	SNP	T	G	G			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr20:50092014T>G	uc002xwd.2	-	4	1736	c.1516A>C	c.(1516-1518)AAA>CAA	p.K506Q	NFATC2_uc002xwc.2_Missense_Mutation_p.K506Q|NFATC2_uc010zyv.1_Missense_Mutation_p.K287Q|NFATC2_uc010zyw.1_Missense_Mutation_p.K287Q|NFATC2_uc010zyx.1_Missense_Mutation_p.K486Q|NFATC2_uc010zyy.1_Missense_Mutation_p.K287Q|NFATC2_uc010zyz.1_Missense_Mutation_p.K287Q|NFATC2_uc002xwe.2_Missense_Mutation_p.K486Q	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	506	RHD.				B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					ATGTTGTTTTTGGGCTCCAAG	0.577													3	209					0	0	0.004672	0	0
ARVCF	421	broad.mit.edu	37	22	19965495	19965495	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr22:19965495C>G	uc002zqz.2	-	8	1955	c.1684G>C	c.(1684-1686)GAC>CAC	p.D562H	ARVCF_uc002zqy.2_Missense_Mutation_p.D84H	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	562	ARM 5.				cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					TTGTCAGTGTCCTTCCGGCCC	0.652													14	38					0	0	0.002450	0	0
CCR3	1232	broad.mit.edu	37	3	46307340	46307340	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr3:46307340A>G	uc003cpg.1	+	4	1234	c.691A>G	c.(691-693)AGT>GGT	p.S231G	CCR3_uc003cpi.1_Missense_Mutation_p.S231G|CCR3_uc003cpj.1_Missense_Mutation_p.S231G|CCR3_uc003cpk.1_Missense_Mutation_p.S252G|CCR3_uc010hjb.1_Missense_Mutation_p.S249G|CCR3_uc003cpl.1_Missense_Mutation_p.S264G	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	231	Cytoplasmic (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		GAGGTGCCCCAGTAAAAAAAA	0.463													26	32					0	0	0.003330	0	0
GNAI2	2771	broad.mit.edu	37	3	50294280	50294280	+	Missense_Mutation	SNP	A	C	C			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr3:50294280A>C	uc003cyq.1	+	6	840	c.719A>C	c.(718-720)GAG>GCG	p.E240A	GNAI2_uc003cyo.1_Missense_Mutation_p.E224A|GNAI2_uc003cyp.1_Missense_Mutation_p.E224A|GNAI2_uc010hlg.1_Missense_Mutation_p.E159A|GNAI2_uc011bdn.1_Missense_Mutation_p.E203A|GNAI2_uc003cyr.1_Missense_Mutation_p.E159A	NM_002070	NP_002061	P04899	GNAI2_HUMAN	guanine nucleotide binding protein (G protein),	240					adenosine receptor signaling pathway|cell cycle|cell division|gamma-aminobutyric acid signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|platelet activation|response to nutrient|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000288)|KIRC - Kidney renal clear cell carcinoma(197;0.00571)|Kidney(197;0.00651)		GAGGACGAGGAGATGGTGAGA	0.577													30	47					0	0	0.009535	0	0
ZXDC	79364	broad.mit.edu	37	3	126194470	126194470	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr3:126194470T>C	uc003eiv.2	-	1	293	c.239A>G	c.(238-240)GAA>GGA	p.E80G	ZXDC_uc010hsh.2_RNA|ZXDC_uc003eix.2_Missense_Mutation_p.E80G	NM_025112	NP_079388	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C isoform 1	80					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.155)		GTGCGGCACTTCCAGCAGCAC	0.468													7	5					0	0	0.008291	0	0
C4orf36	132989	broad.mit.edu	37	4	87809274	87809274	+	Missense_Mutation	SNP	A	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr4:87809274A>T	uc003hqe.3	-	3	533	c.220T>A	c.(220-222)TCT>ACT	p.S74T		NM_144645	NP_653246	Q96KX1	CD036_HUMAN	hypothetical protein LOC132989	74											0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00141)		AGGAACTTACATTCTGCAGAA	0.363													23	51					0	0	0.002780	0	0
PLK4	10733	broad.mit.edu	37	4	128812805	128812805	+	Missense_Mutation	SNP	C	A	A			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr4:128812805C>A	uc003ifo.2	+	9	2252	c.2007C>A	c.(2005-2007)AAC>AAA	p.N669K	PLK4_uc011cgs.1_Missense_Mutation_p.N637K|PLK4_uc011cgt.1_Missense_Mutation_p.N628K	NM_014264	NP_055079	O00444	PLK4_HUMAN	polo-like kinase 4	669					G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						CTACTGACAACATCAGTAGGT	0.318													50	91					1.17673e-23	1.39656e-23	0.014410	1	0
FHDC1	85462	broad.mit.edu	37	4	153896859	153896859	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr4:153896859G>A	uc003inf.2	+	11	2491	c.2416G>A	c.(2416-2418)GGC>AGC	p.G806S		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	806					actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					GGAAGGGGATGGCTCCATGTC	0.652													47	77					0	0	0.014410	0	0
SLC12A7	10723	broad.mit.edu	37	5	1074691	1074691	+	Missense_Mutation	SNP	T	G	G			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr5:1074691T>G	uc003jbu.2	-	16	2129	c.2063A>C	c.(2062-2064)AAG>ACG	p.K688T		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	688					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	CCTCCAGTTCTTGGTGTGGGG	0.657													21	52					0	0	0.006320	0	0
F12	2161	broad.mit.edu	37	5	176831350	176831350	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr5:176831350A>G	uc003mgo.3	-	9	914	c.865T>C	c.(865-867)TAC>CAC	p.Y289H	F12_uc011dfy.1_5'UTR|F12_uc003mgn.3_5'UTR|F12_uc010jkl.2_RNA	NM_000505	NP_000496	P00748	FA12_HUMAN	coagulation factor XII precursor	289	Kringle.				Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGTCGCAGTACTCCCAGCTC	0.697									Hereditary_Angioedema		OREG0017088	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	19					0	0	0.013537	0	0
SKIV2L	6499	broad.mit.edu	37	6	31927082	31927082	+	Missense_Mutation	SNP	C	A	A			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr6:31927082C>A	uc003nyn.1	+	2	420	c.31C>A	c.(31-33)CCT>ACT	p.P11T	RDBP_uc003nyk.2_5'Flank|RDBP_uc011dot.1_5'Flank|RDBP_uc003nyl.1_5'Flank|RDBP_uc003nym.1_5'Flank|MIR1236_hsa-mir-1236|MI0006326_5'Flank|SKIV2L_uc011dou.1_5'UTR|SKIV2L_uc011dov.1_5'UTR	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	11						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						AGTGCTACCCCCTCCAGATCC	0.602													115	259					1.14936e-50	1.41058e-50	0.014410	1	0
PKHD1	5314	broad.mit.edu	37	6	51930865	51930865	+	Silent	SNP	A	G	G			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr6:51930865A>G	uc003pah.1	-	12	1065	c.789T>C	c.(787-789)TCT>TCC	p.S263S	PKHD1_uc003pai.2_Silent_p.S263S	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	263	IPT/TIG 3.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CTGGAAACACAGATAATATTT	0.328													15	31					0	0	0.002450	0	0
PARK2	5071	broad.mit.edu	37	6	162864432	162864432	+	Silent	SNP	C	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr6:162864432C>T	uc003qtx.3	-	2	215	c.81G>A	c.(79-81)AAG>AAA	p.K27K	PARK2_uc010kkd.2_5'UTR|PARK2_uc003qtw.3_5'UTR|PARK2_uc003qty.3_Silent_p.K27K|PARK2_uc003qtz.3_Silent_p.K27K|PARK2_uc010kke.1_Silent_p.K27K	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	27	Ubiquitin-like.				aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		CAACCACCTCCTTGAGCTGGA	0.542													41	96					0	0	0.010771	0	0
FSCN1	6624	broad.mit.edu	37	7	5633277	5633277	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr7:5633277G>A	uc003sou.2	+	1	824	c.710G>A	c.(709-711)AGC>AAC	p.S237N		NM_003088	NP_003079	Q16658	FSCN1_HUMAN	fascin 1	237					actin filament bundle assembly|cell migration|cell proliferation	cell junction|cytoplasm|filopodium|invadopodium|stress fiber	actin filament binding|drug binding|protein binding, bridging			ovary(1)	1		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;1.21e-13)		TCGGGGCCCAGCGGCACGCTC	0.716													3	19					0	0	0.004672	0	0
RELN	5649	broad.mit.edu	37	7	103159949	103159949	+	Silent	SNP	T	C	C			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr7:103159949T>C	uc003vca.2	-	49	7843	c.7683A>G	c.(7681-7683)TTA>TTG	p.L2561L	RELN_uc010liz.2_Silent_p.L2561L	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2561					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAGTGACTAATAATCGACTAC	0.323													5	87					0	0	0.000602	0	0
DOCK4	9732	broad.mit.edu	37	7	111555869	111555869	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr7:111555869G>A	uc003vfx.2	-	13	1426	c.1157C>T	c.(1156-1158)ACA>ATA	p.T386I	DOCK4_uc003vfy.2_Missense_Mutation_p.T386I|DOCK4_uc003vga.1_5'UTR	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	386					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				CAGCTTCCTTGTTATGGATAC	0.368													11	29					0	0	0.010729	0	0
ABP1	26	broad.mit.edu	37	7	150553627	150553627	+	Silent	SNP	G	C	C			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr7:150553627G>C	uc003why.1	+	3	4287	c.69G>C	c.(67-69)CCG>CCC	p.P23P	ABP1_uc003whz.1_Silent_p.P23P|ABP1_uc003wia.1_Silent_p.P23P	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	23					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	AGCCCTCCCCGGGGACTCTGC	0.632													32	40					0	0	0.010818	0	0
KIF13B	23303	broad.mit.edu	37	8	28991695	28991695	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr8:28991695C>G	uc003xhh.3	-	22	2705	c.2646G>C	c.(2644-2646)CAG>CAC	p.Q882H	uc003xhi.1_Intron	NM_015254	NP_056069	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	882					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		GGGACAGATGCTGTGGCAACC	0.478													34	65					0	0	0.006999	0	0
RB1CC1	9821	broad.mit.edu	37	8	53570007	53570007	+	Silent	SNP	C	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr8:53570007C>T	uc003xre.3	-	15	2940	c.2382G>A	c.(2380-2382)CTG>CTA	p.L794L	RB1CC1_uc003xrf.3_Silent_p.L794L	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	794					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				ACTGGACATTCAGAGAAGTAT	0.378													51	99					0	0	0.014410	0	0
C8orf46	254778	broad.mit.edu	37	8	67405943	67405943	+	Silent	SNP	T	A	A	rs139160272	byFrequency	TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr8:67405943T>A	uc003xwg.2	+	1	453	c.60T>A	c.(58-60)ATT>ATA	p.I20I	C8orf46_uc003xwh.2_RNA|C8orf46_uc011let.1_Silent_p.I20I	NM_152765	NP_689978	Q8TAG6	CH046_HUMAN	hypothetical protein LOC254778	20										skin(2)	2			Epithelial(68;0.0224)|BRCA - Breast invasive adenocarcinoma(89;0.0508)|all cancers(69;0.0558)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			CCACCGTGATTCCTTCCAAGG	0.502													20	47					0	0	0.010504	0	0
KCNV2	169522	broad.mit.edu	37	9	2718279	2718279	+	Silent	SNP	C	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr9:2718279C>T	uc003zho.1	+	1	754	c.540C>T	c.(538-540)CGC>CGT	p.R180R		NM_133497	NP_598004	Q8TDN2	KCNV2_HUMAN	potassium channel, subfamily V, member 2	180	Extracellular (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(50;0.0257)		GTCCGCGCCGCTTCCTGGAGG	0.657													6	11					0	0	0.001168	0	0
TLN1	7094	broad.mit.edu	37	9	35699405	35699405	+	Missense_Mutation	SNP	C	A	A			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr9:35699405C>A	uc003zxt.2	-	51	7176	c.6822G>T	c.(6820-6822)AAG>AAT	p.K2274N		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	2274					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CAGCCACACGCTTTGAATGTC	0.562													25	55					2.25844e-05	2.54074e-05	0.007291	1	0
OLFML2A	169611	broad.mit.edu	37	9	127572163	127572163	+	Silent	SNP	C	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr9:127572163C>T	uc004bov.2	+	8	1544	c.1431C>T	c.(1429-1431)TAC>TAT	p.Y477Y	OLFML2A_uc004bow.2_Silent_p.Y263Y	NM_182487	NP_872293	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A precursor	477	Olfactomedin-like.										0						GCGCCTTCTACTACAACCGCG	0.602													28	56					0	0	0.006320	0	0
CCBL1	883	broad.mit.edu	37	9	131607633	131607633	+	Missense_Mutation	SNP	A	T	T			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr9:131607633A>T	uc004bwh.2	-	2	237	c.52T>A	c.(52-54)TGG>AGG	p.W18R	CCBL1_uc004bwf.2_Missense_Mutation_p.W52R|CCBL1_uc004bwg.2_RNA|CCBL1_uc010myn.2_Missense_Mutation_p.W18R|CCBL1_uc004bwj.2_Missense_Mutation_p.W18R|CCBL1_uc011mbl.1_Missense_Mutation_p.W112R|CCBL1_uc004bwi.2_RNA|CCBL1_uc010myo.2_Missense_Mutation_p.W18R	NM_004059	NP_004050	Q16773	KAT1_HUMAN	kynurenine aminotransferase I isoform a	18					kynurenine metabolic process|L-phenylalanine catabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)	1					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)	CTGGCTCACCAGGGGTTGTAG	0.602													7	33					0	0	0.001984	0	0
FAM48B1	100130302	broad.mit.edu	37	X	24381695	24381695	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chrX:24381695G>A	uc011mjx.1	+	1	818	c.818G>A	c.(817-819)AGA>AAA	p.R273K		NM_001136234	NP_001129706			hypothetical protein LOC100130302											kidney(1)	1						AAAGAAGAAAGAAAAGTAGGT	0.512													4	74					0	0	0.009096	0	0
PTEN	5728	broad.mit.edu	37	10	89717645	89717646	+	Frame_Shift_Del	DEL	AT	-	-			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr10:89717645_89717646delAT	uc001kfb.2	+	8	1701_1702	c.670_671delAT	c.(670-672)ATAfs	p.I224fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	224	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.N212fs*1(2)|p.Y27fs*1(2)|p.I224fs*18(2)|p.G165_*404del(1)|p.?(1)|p.G165_K342del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AAAGGTGAAGATATATTCCTCC	0.421		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			84	65	---	---	---	---					
ABCC2	1244	broad.mit.edu	37	10	101606844	101606844	+	Frame_Shift_Del	DEL	G	-	-			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr10:101606844delG	uc001kqf.2	+	30	4412	c.4273delG	c.(4273-4275)GGGfs	p.G1425fs		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	1425	Cytoplasmic (By similarity).|ABC transporter 2.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CCTGCAACTTGGGTTATCCCA	0.537													101	50	---	---	---	---					
MMP21	118856	broad.mit.edu	37	10	127455343	127455343	+	Frame_Shift_Del	DEL	T	-	-			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr10:127455343delT	uc001liu.2	-	7	1598	c.1598delA	c.(1597-1599)AAGfs	p.K533fs		NM_147191	NP_671724	Q8N119	MMP21_HUMAN	matrix metalloproteinase 21 preproprotein	533	Hemopexin-like 4.				proteolysis	extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TTGTTTGTCCTTGTCATTAAC	0.363													63	57	---	---	---	---					
DENND5A	23258	broad.mit.edu	37	11	9173965	9173965	+	Frame_Shift_Del	DEL	G	-	-			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr11:9173965delG	uc001mhl.2	-	13	2716	c.2461delC	c.(2461-2463)CTGfs	p.L821fs	DENND5A_uc001mhk.2_Frame_Shift_Del_p.L164fs|DENND5A_uc010rbw.1_Frame_Shift_Del_p.L821fs|DENND5A_uc010rbx.1_Intron	NM_015213	NP_056028	Q6IQ26	DEN5A_HUMAN	RAB6 interacting protein 1	821	RUN 1.									liver(1)	1						TAATGTAACAGGTGGGACCAT	0.473													58	130	---	---	---	---					
BAIAP3	8938	broad.mit.edu	37	16	1398015	1398021	+	Splice_Site	DEL	ACTTGTG	-	-	rs112608838		TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr16:1398015_1398021delACTTGTG	uc002clk.1	+	32	3254	c.3254_splice	c.e32+1	p.F1085_splice	BAIAP3_uc002clj.2_Splice_Site_p.F1067_splice|BAIAP3_uc010uuz.1_Splice_Site_p.F1050_splice|BAIAP3_uc010uva.1_Splice_Site_p.F1022_splice|BAIAP3_uc010uvc.1_Splice_Site_p.F1014_splice	NM_003933	NP_003924	O94812	BAIP3_HUMAN	BAI1-associated protein 3						G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			pancreas(1)	1		Hepatocellular(780;0.0893)				GAACTCTTCTACTTGTGAGTGTCCTAa	0.580													43	72	---	---	---	---					
ZNF200	7752	broad.mit.edu	37	16	3274128	3274128	+	Frame_Shift_Del	DEL	G	-	-			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr16:3274128delG	uc002cuj.2	-	5	1584	c.952delC	c.(952-954)CGTfs	p.R318fs	ZNF200_uc002cum.3_Frame_Shift_Del_p.R317fs|ZNF200_uc010bti.2_Frame_Shift_Del_p.R317fs|ZNF200_uc002cuk.2_Frame_Shift_Del_p.R318fs|ZNF200_uc002cui.2_Frame_Shift_Del_p.R317fs|ZNF200_uc002cul.3_Frame_Shift_Del_p.R317fs	NM_003454	NP_003445	P98182	ZN200_HUMAN	zinc finger protein 200 isoform 1	318	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						GAATTCTGACGGAAGTTTTTT	0.393													109	125	---	---	---	---					
TRAF4	9618	broad.mit.edu	37	17	27074242	27074243	+	Frame_Shift_Ins	INS	-	C	C			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr17:27074242_27074243insC	uc002hcs.2	+	2	263_264	c.155_156insC	c.(154-156)TTCfs	p.F52fs	TRAF4_uc002hcq.1_Frame_Shift_Ins_p.F52fs	NM_004295	NP_004286	Q9BUZ4	TRAF4_HUMAN	TNF receptor-associated factor 4	52	RING-type.				apoptosis|positive regulation of JNK cascade|positive regulation of protein homodimerization activity|positive regulation of protein kinase activity|regulation of apoptosis|signal transduction	cytoskeleton|nucleus|perinuclear region of cytoplasm|tight junction	DNA binding|ubiquitin-protein ligase activity|WW domain binding|zinc ion binding			upper_aerodigestive_tract(1)|lung(1)	2	Lung NSC(42;0.01)		Epithelial(11;3.26e-05)|all cancers(11;0.000272)|OV - Ovarian serous cystadenocarcinoma(11;0.235)			GAAGGAGTCTTCAAGTGCCCTG	0.594													82	77	---	---	---	---					
COL5A2	1290	broad.mit.edu	37	2	189898818	189898819	+	Frame_Shift_Ins	INS	-	TT	TT			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr2:189898818_189898819insTT	uc002uqk.2	-	54	4752_4753	c.4477_4478insAA	c.(4477-4479)ATTfs	p.I1493fs	COL5A2_uc010frx.2_Frame_Shift_Ins_p.I1069fs	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1493	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			AACTGGCCCAATTTCAACGCCG	0.460													15	50	---	---	---	---					
ANKZF1	55139	broad.mit.edu	37	2	220099806	220099806	+	Frame_Shift_Del	DEL	C	-	-			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr2:220099806delC	uc002vkg.2	+	10	1637	c.1463delC	c.(1462-1464)GCCfs	p.A488fs	ANKZF1_uc010zkv.1_3'UTR|ANKZF1_uc010zkw.1_3'UTR|ANKZF1_uc002vkh.2_Frame_Shift_Del_p.A278fs|ANKZF1_uc002vki.2_Frame_Shift_Del_p.A488fs|ANKZF1_uc002vkj.1_3'UTR	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	488						intracellular	zinc ion binding			ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GAGGCCAAAGCCCCTGGTCAG	0.587													20	51	---	---	---	---					
PKDREJ	10343	broad.mit.edu	37	22	46655720	46655720	+	Frame_Shift_Del	DEL	G	-	-			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr22:46655720delG	uc003bhh.2	-	1	3500	c.3500delC	c.(3499-3501)CCTfs	p.P1167fs		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1167	Extracellular (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		CACAGGATTAGGGATCACAAT	0.493													50	158	---	---	---	---					
MAT2B	27430	broad.mit.edu	37	5	162940576	162940577	+	Frame_Shift_Ins	INS	-	A	A			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr5:162940576_162940577insA	uc003lzk.2	+	3	382_383	c.274_275insA	c.(274-276)CATfs	p.H92fs	MAT2B_uc003lzj.2_Frame_Shift_Ins_p.H81fs|MAT2B_uc003lzl.1_Frame_Shift_Ins_p.H92fs	NM_013283	NP_037415	Q9NZL9	MAT2B_HUMAN	methionine adenosyltransferase II, beta isoform	92					extracellular polysaccharide biosynthetic process|methylation|S-adenosylmethionine biosynthetic process|xenobiotic metabolic process	cytosol|methionine adenosyltransferase complex|nucleus	dTDP-4-dehydrorhamnose reductase activity|methionine adenosyltransferase regulator activity|protein binding			upper_aerodigestive_tract(1)	1	Renal(175;0.000281)	Medulloblastoma(196;0.0208)|all_neural(177;0.0765)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.027)|OV - Ovarian serous cystadenocarcinoma(192;0.0406)|Epithelial(171;0.0797)	L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	TGTTATAGTACATTGTGCAGCA	0.371													37	68	---	---	---	---					
CLTB	1212	broad.mit.edu	37	5	175843340	175843342	+	In_Frame_Del	DEL	AGA	-	-			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr5:175843340_175843342delAGA	uc003meh.2	-	2	198_200	c.23_25delTCT	c.(22-27)TTCTCG>TCG	p.F8del	CLTB_uc003mei.2_In_Frame_Del_p.F8del|CLTB_uc011dfn.1_RNA	NM_007097	NP_009028	P09497	CLCB_HUMAN	clathrin, light polypeptide isoform b	8					intracellular protein transport|vesicle-mediated transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle	protein binding|structural molecule activity				0	all_cancers(89;0.00522)|Renal(175;0.000269)|Lung NSC(126;0.0105)|all_lung(126;0.0168)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.098)		TCCGACGACGAGAAGAAGCCAAA	0.724													15	21	---	---	---	---					
CYP21A2	1589	broad.mit.edu	37	6	32007842	32007846	+	Frame_Shift_Del	DEL	CAGCC	-	-	rs142028935	byFrequency	TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr6:32007842_32007846delCAGCC	uc003nze.1	+	7	917_921	c.799_803delCAGCC	c.(799-804)CAGCCGfs	p.Q267fs	CYP21A2_uc003nzf.1_Frame_Shift_Del_p.Q237fs	NM_000500	NP_000491	P08686	CP21A_HUMAN	cytochrome P450, family 21, subfamily A,	266_267					glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding				0						AGGGGTGGCGCAGCCGAGCATGGAA	0.639													33	233	---	---	---	---					
AGPAT1	10554	broad.mit.edu	37	6	32139261	32139268	+	Frame_Shift_Del	DEL	GCCACAAA	-	-			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr6:32139261_32139268delGCCACAAA	uc003oae.2	-	2	324_331	c.6_13delTTTGTGGC	c.(4-15)GATTTGTGGCCAfs	p.D2fs	PPT2_uc003nzy.1_RNA|AGPAT1_uc011dpj.1_RNA|AGPAT1_uc011dpk.1_5'UTR|AGPAT1_uc003oaf.2_Frame_Shift_Del_p.D2fs|AGPAT1_uc003oag.2_5'UTR|AGPAT1_uc003oah.2_Frame_Shift_Del_p.D2fs|AGPAT1_uc003oai.1_Frame_Shift_Del_p.D2fs|AGPAT1_uc011dpl.1_5'UTR	NM_006411	NP_006402	Q99943	PLCA_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 1	2_5					energy reserve metabolic process|phosphatidic acid biosynthetic process|positive regulation of cellular metabolic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			central_nervous_system(1)	1						CATGCCCCTGGCCACAAATCCATTCTGG	0.481													9	14	---	---	---	---					
MPP6	51678	broad.mit.edu	37	7	24727063	24727075	+	Frame_Shift_Del	DEL	GACTTGAAGAAAA	-	-			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr7:24727063_24727075delGACTTGAAGAAAA	uc003swx.2	+	13	1752_1764	c.1453_1465delGACTTGAAGAAAA	c.(1453-1467)GACTTGAAGAAAACAfs	p.D485fs	MPP6_uc003swy.2_Frame_Shift_Del_p.D485fs|MPP6_uc010kur.2_Frame_Shift_Del_p.D153fs	NM_016447	NP_057531	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6	485_489	Guanylate kinase-like.				protein complex assembly		protein binding				0						ACAGGACTCTGACTTGAAGAAAACAGTGGATGA	0.324													50	94	---	---	---	---					
ZMIZ2	83637	broad.mit.edu	37	7	44807159	44807159	+	Frame_Shift_Del	DEL	G	-	-			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr7:44807159delG	uc003tlr.2	+	19	2823	c.2700delG	c.(2698-2700)TTGfs	p.L900fs	ZMIZ2_uc003tlq.2_Frame_Shift_Del_p.L842fs|ZMIZ2_uc003tls.2_Frame_Shift_Del_p.L874fs|ZMIZ2_uc003tlt.2_Frame_Shift_Del_p.L523fs|ZMIZ2_uc010kyj.2_Frame_Shift_Del_p.L422fs|ZMIZ2_uc003tlu.2_Frame_Shift_Del_p.L181fs|ZMIZ2_uc010kyk.1_5'Flank	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	900	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5						TGTCCTACTTGGGCCCACCCG	0.552													24	99	---	---	---	---					
TRAPPC9	83696	broad.mit.edu	37	8	141449171	141449172	+	Frame_Shift_Del	DEL	TT	-	-			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chr8:141449171_141449172delTT	uc003yvj.2	-	3	843_844	c.709_710delAA	c.(709-711)AATfs	p.N237fs	TRAPPC9_uc003yvh.2_Frame_Shift_Del_p.N335fs|TRAPPC9_uc003yvi.1_Frame_Shift_Del_p.N237fs	NM_001160372	NP_001153844	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9 isoform	237					cell differentiation	endoplasmic reticulum|Golgi apparatus				skin(2)	2						CAGAAAGTCATTCACAGAACGC	0.455													72	88	---	---	---	---					
RLIM	51132	broad.mit.edu	37	X	73815805	73815805	+	Frame_Shift_Del	DEL	T	-	-			TCGA-A4-7996-01A-11D-2201-08	TCGA-A4-7996-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cf8d4b0-1532-48a1-ac95-242f1fc0a867	5b059d3b-661d-4e07-b668-c140b421ade8	g.chrX:73815805delT	uc004ebu.2	-	3	298	c.8delA	c.(7-9)AACfs	p.N3fs	RLIM_uc004ebw.2_Frame_Shift_Del_p.N3fs	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	3					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						GGAATCTGAGTTTTCCATATT	0.358													31	38	---	---	---	---					
