Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TCHH	7062	broad.mit.edu	37	1	152082565	152082565	+	Missense_Mutation	SNP	A	C	C			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr1:152082565A>C	uc001ezp.2	-	2	3128	c.3128T>G	c.(3127-3129)CTC>CGC	p.L1043R	TCHH_uc009wne.1_Missense_Mutation_p.L1043R	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1043	10 X 30 AA tandem repeats.|4-5.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCGCTCCTGGAGTCTTCTTTT	0.254000													5	231					0	0	0.029380	0	0
HHIPL2	79802	broad.mit.edu	37	1	222717024	222717024	+	Missense_Mutation	SNP	A	C	C			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr1:222717024A>C	uc001hnh.1	-	2	887	c.829T>G	c.(829-831)TTG>GTG	p.L277V		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	277					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		TGAAAAGCCAACCCCAAGAAG	0.493000													10	110					0	0	0.098360	0	0
PARG	8505	broad.mit.edu	37	10	51093329	51093329	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr10:51093329C>T	uc001jif.2	-	8	2011	c.1750G>A	c.(1750-1752)GCA>ACA	p.A584T	PARG_uc001jih.2_Missense_Mutation_p.A584T|PARG_uc001jig.2_Missense_Mutation_p.A170T|PARG_uc010qgv.1_Intron|PARG_uc009xoi.2_Intron|PARG_uc010qgw.1_Missense_Mutation_p.A475T|PARG_uc009xoj.2_Missense_Mutation_p.A135T|PARG_uc010qgx.1_Missense_Mutation_p.A502T	NM_003631	NP_003622	Q86W56	PARG_HUMAN	poly (ADP-ribose) glycohydrolase	584					carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity			ovary(2)	2				Epithelial(53;0.213)		TGAGCTTCTGCTTCTTCAAGT	0.318000													3	32					0	0	0.115264	0	0
KRTAP5-4	387267	broad.mit.edu	37	11	1643252	1643252	+	Silent	SNP	A	G	G			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr11:1643252A>G	uc009ycy.1	-	1	117	c.30T>C	c.(28-30)TGT>TGC	p.C10C		NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	24						keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		agccagagccacagcccccac	0.254000													15	104					0	0	0.049695	0	0
MRGPRX4	117196	broad.mit.edu	37	11	18195248	18195248	+	Silent	SNP	C	T	T			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr11:18195248C>T	uc001mnv.1	+	1	865	c.445C>T	c.(445-447)CTG>TTG	p.L149L		NM_054032	NP_473373	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	149	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						GCTCTGGGGCCTGTCCCTGCT	0.577000													98	529					0	0	0.139131	0	0
NAALAD2	10003	broad.mit.edu	37	11	89911214	89911214	+	Missense_Mutation	SNP	A	T	T			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr11:89911214A>T	uc001pdf.3	+	16	1896	c.1787A>T	c.(1786-1788)AAC>ATC	p.N596I	NAALAD2_uc009yvx.2_Missense_Mutation_p.N563I|NAALAD2_uc009yvy.2_Intron	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	596	Extracellular (Potential).				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				GCTTTGAAAAACTATGCAGCA	0.343000													5	218					0	0	0.014758	0	0
MLL2	8085	broad.mit.edu	37	12	49445198	49445198	+	Silent	SNP	A	G	G			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr12:49445198A>G	uc001rta.3	-	10	2268	c.2268T>C	c.(2266-2268)CCT>CCC	p.P756P		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	756	Pro-rich.			Missing (in Ref. 1; AAC51734).	chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GTGGCTCCTCAGGCCGGGGGG	0.692000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			3	67					0	0	0.115264	0	0
TAOK3	51347	broad.mit.edu	37	12	118599637	118599637	+	Nonsense_Mutation	SNP	T	A	A			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr12:118599637T>A	uc001twx.2	-	18	2390	c.2095A>T	c.(2095-2097)AGA>TGA	p.R699*	TAOK3_uc001twv.2_Nonsense_Mutation_p.R239*|TAOK3_uc001tww.2_Nonsense_Mutation_p.R529*|TAOK3_uc001twy.3_Nonsense_Mutation_p.R699*	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	699					MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACATGCTTTCTGTGCAGTTCT	0.423000													78	228					0	0	0.139131	0	0
REC8	9985	broad.mit.edu	37	14	24646579	24646579	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr14:24646579G>C	uc001wmr.2	+	11	1154	c.727G>C	c.(727-729)GCT>CCT	p.A243P	REC8_uc001wms.2_Missense_Mutation_p.A243P	NM_005132	NP_005123	O95072	REC8_HUMAN	REC8 homolog	243	Pro-rich.|Glu-rich.				mitotic metaphase/anaphase transition|mitotic prometaphase|reciprocal meiotic recombination|sister chromatid cohesion	nucleoplasm					0				GBM - Glioblastoma multiforme(265;0.00839)		CCCACCTCCAGCTCCTGCAGA	0.567000													63	68					0	0	0.139131	0	0
HERC2P2	400322	broad.mit.edu	37	15	23316050	23316050	+	Silent	SNP	G	A	A			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr15:23316050G>A	uc001yvr.2	-	17	2630	c.2430C>T	c.(2428-2430)TGC>TGT	p.C810C	HERC2P2_uc010ayf.1_RNA|HERC2P2_uc001yvp.3_RNA					RecName: Full=Putative HERC2-like protein 3;												0						GCAGCAGTCCGCATAAAGTCT	0.512000													5	216					0	0	0.029380	0	0
VPS53	55275	broad.mit.edu	37	17	465803	465803	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr17:465803G>A	uc002frn.2	-	14	1643	c.1496C>T	c.(1495-1497)ACC>ATC	p.T499I	VPS53_uc002frk.2_Missense_Mutation_p.T18I|VPS53_uc010cjo.1_Missense_Mutation_p.T499I|VPS53_uc002frl.2_RNA|VPS53_uc002frm.2_Missense_Mutation_p.T470I|VPS53_uc002fro.2_Missense_Mutation_p.T301I|VPS53_uc010cjp.1_Missense_Mutation_p.T222I	NM_018289	NP_060759	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 isoform 2	499					protein transport	endosome membrane|Golgi apparatus					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		CTGGAAAATGGTGGTCAGGGC	0.537000													4	138					0	0	0.150653	0	0
LOC162632	162632	broad.mit.edu	37	17	16701804	16701804	+	RNA	SNP	C	T	T			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr17:16701804C>T	uc010cpj.1	+	18		c.4335C>T			LOC162632_uc010cpk.1_RNA|LOC162632_uc010vwq.1_RNA|LOC162632_uc002gqm.2_RNA					Homo sapiens mRNA for KIAA0565 protein, partial cds.												0						TGAGCAAAAGCCCATCCTCAC	0.532000													7	89					0	0	0.047766	0	0
FAM83G	644815	broad.mit.edu	37	17	18874919	18874919	+	Missense_Mutation	SNP	T	G	G			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr17:18874919T>G	uc002guw.2	-	6	2392	c.2225A>C	c.(2224-2226)CAC>CCC	p.H742P	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	742										ovary(1)|central_nervous_system(1)	2						CTGCCAGTGGTGGGGGCCAGC	0.662000													6	59					0	0	0.091800	0	0
MRC2	9902	broad.mit.edu	37	17	60766323	60766323	+	Splice_Site	SNP	T	C	C			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr17:60766323T>C	uc002jad.2	+	23	3736	c.3334_splice	c.e23+2	p.D1112_splice	MRC2_uc002jae.2_Splice_Site_p.D183_splice|MRC2_uc002jaf.2_Splice_Site_p.R57_splice	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2						endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						AGGGCACGGGTATGTGTCACC	0.642000													12	47					0	0	0.105934	0	0
UBA52	7311	broad.mit.edu	37	19	18685757	18685757	+	Missense_Mutation	SNP	A	T	T			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr19:18685757A>T	uc002njr.2	+	4	382	c.268A>T	c.(268-270)AAC>TAC	p.N90Y	UBA52_uc002njs.2_Missense_Mutation_p.N90Y|UBA52_uc002njt.2_Missense_Mutation_p.N90Y	NM_001033930	NP_001029102	P62987	RL40_HUMAN	ubiquitin and ribosomal protein L40 precursor	90					activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endocrine pancreas development|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|translational elongation|translational termination|viral transcription	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane|ribosome	protein binding|structural constituent of ribosome				0						CCAGAAATACAACTGCGACAA	0.612000													10	88					0	0	0.080935	0	0
ALK	238	broad.mit.edu	37	2	29432730	29432730	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr2:29432730C>G	uc002rmy.2	-	25	4665	c.3758G>C	c.(3757-3759)AGA>ACA	p.R1253T	ALK_uc010ymo.1_Missense_Mutation_p.R185T	NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	1253	Protein kinase.|Cytoplasmic (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GAGGCAGTTTCTGGCAGCAAT	0.493000			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				12	77					0	0	0.119110	0	0
TTN	7273	broad.mit.edu	37	2	179476553	179476553	+	Missense_Mutation	SNP	G	T	T			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr2:179476553G>T	uc010zfg.1	-	217	43003	c.42779C>A	c.(42778-42780)GCT>GAT	p.A14260D	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.A7955D|TTN_uc010zfi.1_Missense_Mutation_p.A7888D|TTN_uc010zfj.1_Missense_Mutation_p.A7763D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15187							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCATTTTCAGCCCGAACCTG	0.458000													12	25					9.31168e-06	1.12288e-05	0.105934	1	0
THBD	7056	broad.mit.edu	37	20	23029807	23029807	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr20:23029807G>A	uc002wss.2	-	1	495	c.335C>T	c.(334-336)ACG>ATG	p.T112M	THBD_uc002wst.1_5'Flank|THBD_uc002wsu.1_Missense_Mutation_p.T53M	NM_000361	NP_000352	P07204	TRBM_HUMAN	thrombomodulin precursor	112	C-type lectin.|Extracellular (Potential).				blood coagulation|leukocyte migration|negative regulation of fibrinolysis|negative regulation of platelet activation	cell surface|integral to plasma membrane	calcium ion binding|protein binding|transmembrane receptor activity				0	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)				Drotrecogin alfa(DB00055)	GTTGTCTCCCGTAACCCACTG	0.716000													3	8					0	0	0.014758	0	0
CDC42EP1	11135	broad.mit.edu	37	22	37962631	37962631	+	Missense_Mutation	SNP	T	G	G			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr22:37962631T>G	uc003asz.3	+	2	678	c.275T>G	c.(274-276)GTG>GGG	p.V92G		NM_152243	NP_689449	Q00587	BORG5_HUMAN	CDC42 effector protein 1	92					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|endomembrane system|Golgi apparatus|plasma membrane	protein binding				0	Melanoma(58;0.0574)					GTGCGGAGGGTGGGGGCGCCC	0.697000													8	26					0	0	0.099896	0	0
SLC9A10	285335	broad.mit.edu	37	3	111958847	111958847	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr3:111958847C>G	uc003dyu.2	-	12	1508	c.1286G>C	c.(1285-1287)CGT>CCT	p.R429P	SLC9A10_uc011bhu.1_5'UTR|SLC9A10_uc010hqc.2_Missense_Mutation_p.R381P	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	429					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						TGTGGCATCACGAAGACCTTT	0.338000													3	88					0	0	0.115264	0	0
PLXND1	23129	broad.mit.edu	37	3	129284750	129284750	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr3:129284750C>A	uc003emx.2	-	24	4402	c.4302G>T	c.(4300-4302)AAG>AAT	p.K1434N	PLXND1_uc011blb.1_Missense_Mutation_p.K102N	NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1434	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						CCGCAAAGTCCTTCTGCTGCT	0.587000													11	75					0.00010058	0.000114549	0.093190	1	0
CLSTN2	64084	broad.mit.edu	37	3	140122510	140122510	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr3:140122510C>A	uc003etn.2	+	3	462	c.272C>A	c.(271-273)CCC>CAC	p.P91H	CLSTN2_uc003etm.2_Missense_Mutation_p.P91H	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	91	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CAGGAGCTGCCCTTTGAGGCT	0.532000										HNSCC(16;0.037)			63	193					2.69673e-31	3.56665e-31	0.139131	1	0
SLC2A2	6514	broad.mit.edu	37	3	170727776	170727776	+	Missense_Mutation	SNP	G	T	T			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr3:170727776G>T	uc003fhe.1	-	4	776	c.467C>A	c.(466-468)GCT>GAT	p.A156D	SLC2A2_uc003fhf.1_Intron|SLC2A2_uc011bpu.1_Missense_Mutation_p.A29D	NM_000340	NP_000331	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose	156	Extracellular (Potential).				carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			GCTTCTTCCAGCAATTATAAG	0.294000													3	13					6.4e-05	7.49714e-05	0.115264	1	0
OR2Y1	134083	broad.mit.edu	37	5	180166493	180166493	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr5:180166493G>A	uc003mmf.1	-	1	566	c.566C>T	c.(565-567)GCG>GTG	p.A189V		NM_001001657	NP_001001657	Q8NGV0	OR2Y1_HUMAN	olfactory receptor, family 2, subfamily Y,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(89;1.25e-05)|all_epithelial(37;4.36e-06)|Renal(175;0.000159)|Lung NSC(126;0.00317)|all_lung(126;0.0041)|Breast(19;0.114)	all_cancers(40;0.0834)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCTGTGTCCGCACAAGCCAA	0.507000													5	162					0	0	0.014758	0	0
PBX2	5089	broad.mit.edu	37	6	32155509	32155509	+	Missense_Mutation	SNP	T	A	A			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr6:32155509T>A	uc003oav.1	-	5	1056	c.785A>T	c.(784-786)TAT>TTT	p.Y262F	PBX2_uc003oaw.2_Missense_Mutation_p.Y262F	NM_002586	NP_002577	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	262	Homeobox; TALE-type.						transcription factor binding			ovary(1)	1						GGAGTAGAAATACTCATTTAG	0.517000													3	17					0	0	0.150653	0	0
LYPLA2P1	653639	broad.mit.edu	37	6	33333342	33333342	+	Silent	SNP	G	A	A	rs140475230	by1000genomes	TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr6:33333342G>A	uc003shx.2	-	1	798	c.664C>T	c.(664-666)CTG>TTG	p.L222L		NR_001444				SubName: Full=Lysophospholipase II; Flags: Fragment;												0						GGAGGCAGCAGCTTCTCAAGA	0.562000													3	33					0	0	0.021553	0	0
RBAK	57786	broad.mit.edu	37	7	5105227	5105227	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr7:5105227C>T	uc010kss.1	+	6	2464	c.2140C>T	c.(2140-2142)CTC>TTC	p.L714F	LOC389458_uc003snr.2_Intron|RBAK_uc003sns.1_Missense_Mutation_p.L714F	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	714	Interaction with AR.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		TGTGGAAAATCTCTGAAGTCA	0.373000													13	38					0	0	0.119110	0	0
EPDR1	54749	broad.mit.edu	37	7	37960767	37960767	+	Missense_Mutation	SNP	G	T	T			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr7:37960767G>T	uc003tfp.2	+	1	605	c.586G>T	c.(586-588)GTG>TTG	p.V196L	EPDR1_uc003tfq.2_Missense_Mutation_p.V196L|EPDR1_uc010kxh.2_5'Flank	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	76					cell-matrix adhesion	extracellular region	calcium ion binding			upper_aerodigestive_tract(1)	1						CAACCAGCGCGTGCGGGTGCT	0.706000													12	86					6.31663e-08	7.84793e-08	0.132662	1	0
SRRT	51593	broad.mit.edu	37	7	100485034	100485034	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr7:100485034G>A	uc003uwy.2	+	17	2337	c.2069G>A	c.(2068-2070)CGC>CAC	p.R690H	SRRT_uc010lhl.1_Missense_Mutation_p.R689H|SRRT_uc003uxa.2_Missense_Mutation_p.R689H|SRRT_uc003uwz.2_Missense_Mutation_p.R690H	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	690					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						AAGATGGGGCGCAAAGACCCA	0.552000													6	316					0	0	0.021553	0	0
CREB3	10488	broad.mit.edu	37	9	35733059	35733059	+	Missense_Mutation	SNP	A	G	G			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr9:35733059A>G	uc003zxv.2	+	2	649	c.196A>G	c.(196-198)ATT>GTT	p.I66V	TLN1_uc003zxt.2_5'Flank|TLN1_uc003zxu.3_5'Flank|CREB3_uc010mla.2_5'UTR	NM_006368	NP_006359	O43889	CREB3_HUMAN	cAMP responsive element binding protein 3	66	Cytoplasmic (Potential).|Transcription activation (acidic).				chemotaxis|induction of positive chemotaxis|interspecies interaction between organisms|negative regulation of cell cycle|positive regulation of calcium ion transport|positive regulation of cell migration|positive regulation of transcription, DNA-dependent|reactivation of latent virus|regulation of cell proliferation	cytosol|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|integral to membrane|nucleus|nucleus	cAMP response element binding protein binding|CCR1 chemokine receptor binding|DNA binding|protein dimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity				0	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)	GBM - Glioblastoma multiforme(74;0.0285)		GTCGTTGAACATTCTCAGCTC	0.537000													59	64					0	0	0.139131	0	0
EGFL6	25975	broad.mit.edu	37	X	13635856	13635856	+	Silent	SNP	T	C	C			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chrX:13635856T>C	uc004cvi.2	+	8	1026	c.786T>C	c.(784-786)CCT>CCC	p.P262P	EGFL6_uc004cvj.2_Silent_p.P262P|EGFL6_uc011mik.1_Silent_p.P163P	NM_015507	NP_056322	Q8IUX8	EGFL6_HUMAN	epidermal growth factor-like protein 6	262					cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)	2						TAGCTATCCCTGAAAATTCTG	0.343000													4	452					0	0	0.150653	0	0
PLS3	5358	broad.mit.edu	37	X	114874764	114874764	+	Silent	SNP	A	G	G			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chrX:114874764A>G	uc004eqd.2	+	9	1326	c.936A>G	c.(934-936)AAA>AAG	p.K312K	PLS3_uc010nqg.2_Silent_p.K94K|PLS3_uc011mtf.1_Silent_p.K299K|PLS3_uc004eqe.2_Silent_p.K312K|PLS3_uc011mtg.1_Silent_p.K285K|PLS3_uc011mth.1_Silent_p.K267K|PLS3_uc011mti.1_5'UTR|PLS3_uc011mtj.1_5'UTR|PLS3_uc011mtk.1_5'Flank|PLS3_uc011mtl.1_5'Flank	NM_005032	NP_005023	P13797	PLST_HUMAN	plastin 3	312	CH 2.|Actin-binding 1.					cytoplasm	actin binding|calcium ion binding			lung(1)|breast(1)	2						TCGCACCAAAAGGACAAAAGG	0.348000													3	137					0	0	0.115264	0	0
ELF4	2000	broad.mit.edu	37	X	129203444	129203444	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chrX:129203444G>A	uc004evd.3	-	8	1403	c.1018C>T	c.(1018-1020)CCC>TCC	p.P340S	ELF4_uc004eve.3_Missense_Mutation_p.P340S	NM_001421	NP_001412	Q99607	ELF4_HUMAN	E74-like factor 4	340					natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTGCCCTGGGGGGCAGATCTG	0.622000			T	ERG	AML								152	336					0	0	0.139131	0	0
SAV1	60485	broad.mit.edu	37	14	51132122	51132129	+	Frame_Shift_Del	DEL	CTAGACTT	-	-			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr14:51132122_51132129delCTAGACTT	uc001wyg.1	-	3	464_471	c.303_310delAAGTCTAG	c.(301-312)AGAAGTCTAGCAfs	p.R101fs	SAV1_uc001wyh.1_Frame_Shift_Del_p.R101fs	NM_021818	NP_068590	Q9H4B6	SAV1_HUMAN	WW45 protein	101_104					hippo signaling cascade	cytoplasm|nucleus	identical protein binding			breast(1)	1	all_epithelial(31;0.000611)|Breast(41;0.0333)					GGGACATCTGCTAGACTTCTGGCAAGAT	0.385													13	17	---	---	---	---					
BRSK1	84446	broad.mit.edu	37	19	55815036	55815036	+	Frame_Shift_Del	DEL	C	-	-			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr19:55815036delC	uc002qkg.2	+	12	1405	c.1128delC	c.(1126-1128)GACfs	p.D376fs	BRSK1_uc002qkf.2_Frame_Shift_Del_p.D392fs|BRSK1_uc002qkh.2_Frame_Shift_Del_p.D71fs	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	376					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GTCCCTCAGACCCCCCCCGGA	0.453													9	349	---	---	---	---					
