Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RER1	11079	broad.mit.edu	37	1	2332308	2332308	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr1:2332308C>G	uc001aje.1	+	5	490	c.299C>G	c.(298-300)TCG>TGG	p.S100W	RER1_uc001ajf.1_Missense_Mutation_p.S100W	NM_007033	NP_008964	O15258	RER1_HUMAN	RER1 retention in endoplasmic reticulum 1	100					retrograde vesicle-mediated transport, Golgi to ER	integral to Golgi membrane					0	all_cancers(77;0.000247)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;5.35e-20)|all_lung(118;2.78e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.28e-37)|OV - Ovarian serous cystadenocarcinoma(86;8.29e-23)|GBM - Glioblastoma multiforme(42;4.71e-08)|Colorectal(212;4.73e-05)|COAD - Colon adenocarcinoma(227;0.00021)|Kidney(185;0.00116)|BRCA - Breast invasive adenocarcinoma(365;0.00459)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0182)|Lung(427;0.204)		GACGGTCCTTCGCTACCCACC	0.478													3	150					0	0	0.009096	0	0
MST1P9	11223	broad.mit.edu	37	1	17085865	17085865	+	Missense_Mutation	SNP	A	G	G	rs1057378	by1000genomes	TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr1:17085865A>G	uc010ock.1	-	8	956	c.956T>C	c.(955-957)CTC>CCC	p.L319P	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_5'UTR	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						TGAGCCGTCGAGGTTCCAGCA	0.667													3	38					0	0	0.001168	0	0
SORCS1	114815	broad.mit.edu	37	10	108427534	108427534	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr10:108427534T>C	uc001kym.2	-	17	2224	c.2216A>G	c.(2215-2217)AAT>AGT	p.N739S	SORCS1_uc001kyl.2_Missense_Mutation_p.N739S|SORCS1_uc009xxs.2_Missense_Mutation_p.N739S|SORCS1_uc001kyn.1_Missense_Mutation_p.N739S|SORCS1_uc001kyo.2_Missense_Mutation_p.N739S	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	739	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GCACTGGCCATTGCTGTGTCG	0.458													26	2					0	0	0.008361	0	0
OR52J3	119679	broad.mit.edu	37	11	5068288	5068288	+	Missense_Mutation	SNP	A	T	T			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr11:5068288A>T	uc010qyv.1	+	1	533	c.533A>T	c.(532-534)CAT>CTT	p.H178L		NM_001001916	NP_001001916	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|lung(1)|skin(1)	3		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATAATAGCCCATTCCTACTGT	0.418													86	5					0	0	0.014410	0	0
IL10RA	3587	broad.mit.edu	37	11	117866403	117866403	+	Missense_Mutation	SNP	G	A	A	rs145975996		TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr11:117866403G>A	uc001prv.2	+	6	865	c.788G>A	c.(787-789)CGA>CAA	p.R263Q	IL10RA_uc010rxl.1_Missense_Mutation_p.R243Q|IL10RA_uc010rxm.1_Missense_Mutation_p.R243Q|IL10RA_uc010rxn.1_Missense_Mutation_p.R114Q|IL10RA_uc001prw.2_Missense_Mutation_p.R114Q	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor	263	Cytoplasmic (Potential).					integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		GTGCGGCGCCGAAAGAAGCTA	0.602													19	17					0	0	0.006122	0	0
EFHA1	221154	broad.mit.edu	37	13	22088516	22088516	+	Silent	SNP	C	T	T			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr13:22088516C>T	uc001uof.2	-	7	661	c.639G>A	c.(637-639)GTG>GTA	p.V213V	EFHA1_uc010tct.1_Silent_p.V3V	NM_152726	NP_689939	Q8IYU8	EFHA1_HUMAN	EF-hand domain family, member A1	213							calcium ion binding				0		all_cancers(29;1.24e-15)|all_epithelial(30;5.4e-14)|all_lung(29;2.04e-13)|Lung SC(185;0.0367)		all cancers(112;0.000171)|Epithelial(112;0.000398)|OV - Ovarian serous cystadenocarcinoma(117;0.00641)|Lung(94;0.189)		CATTAGTTTTCACTGTCATCA	0.318													7	69					0	0	0.004482	0	0
KL	9365	broad.mit.edu	37	13	33591068	33591068	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr13:33591068G>C	uc001uus.2	+	1	498	c.490G>C	c.(490-492)GTC>CTC	p.V164L	KL_uc001uur.1_Intron	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	164	Glycosyl hydrolase-1 1.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		CAGCGCGGGCGTCCCCAACCG	0.711													5	7					0	0	0.004482	0	0
RANBP10	57610	broad.mit.edu	37	16	67840335	67840335	+	Silent	SNP	C	T	T			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr16:67840335C>T	uc002eud.2	-	1	221	c.105G>A	c.(103-105)CTG>CTA	p.L35L	RANBP10_uc010ceo.2_5'UTR|RANBP10_uc010vju.1_Silent_p.L35L|RANBP10_uc010vjv.1_5'UTR|RANBP10_uc010vjx.1_Silent_p.L35L|RANBP10_uc010vjy.1_5'UTR|TSNAXIP1_uc010cep.2_5'Flank|TSNAXIP1_uc010vjz.1_5'Flank|TSNAXIP1_uc002euf.3_5'Flank|TSNAXIP1_uc010vka.1_5'Flank|TSNAXIP1_uc010vkb.1_5'Flank|TSNAXIP1_uc002eug.3_5'Flank|TSNAXIP1_uc002euh.3_5'Flank|TSNAXIP1_uc002eui.3_5'Flank|TSNAXIP1_uc002euj.2_5'Flank	NM_020850	NP_065901	Q6VN20	RBP10_HUMAN	RAN binding protein 10	35	B30.2/SPRY.									ovary(1)	1		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)		AGCGCCGGCTCAGCTCCTGCT	0.701													5	11					0	0	0.001168	0	0
ZFHX3	463	broad.mit.edu	37	16	72984648	72984648	+	Missense_Mutation	SNP	A	C	C			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr16:72984648A>C	uc002fck.2	-	3	3609	c.2936T>G	c.(2935-2937)GTG>GGG	p.V979G	ZFHX3_uc002fcl.2_Missense_Mutation_p.V65G	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	979					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				GTCCCCCATCACCGCCTTCCA	0.592													4	91					0	0	0.003080	0	0
AKAP10	11216	broad.mit.edu	37	17	19861611	19861611	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr17:19861611A>G	uc002gwo.2	-	4	730	c.593T>C	c.(592-594)TTT>TCT	p.F198S	AKAP10_uc002gwp.1_Missense_Mutation_p.F198S|AKAP10_uc010cqw.1_Missense_Mutation_p.F198S|AKAP10_uc010vze.1_Missense_Mutation_p.F119S	NM_007202	NP_009133	O43572	AKA10_HUMAN	A-kinase anchor protein 10 precursor	198	RGS 1.				blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			skin(1)	1	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					ATCAGTTAAAAAAGACGCTGT	0.418													41	44					0	0	0.006230	0	0
C17orf57	124989	broad.mit.edu	37	17	45490253	45490253	+	Missense_Mutation	SNP	A	G	G	rs137885108		TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr17:45490253A>G	uc002iln.2	+	22	2804	c.2393A>G	c.(2392-2394)AAT>AGT	p.N798S	C17orf57_uc002ilm.2_Missense_Mutation_p.N702S	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	798	EF-hand 5.						calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3						GAGGACTTCAATGAAGCCCTT	0.363													41	151					0	0	0.014410	0	0
MUC16	94025	broad.mit.edu	37	19	9065718	9065718	+	Missense_Mutation	SNP	G	T	T			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr19:9065718G>T	uc002mkp.2	-	3	21932	c.21728C>A	c.(21727-21729)TCC>TAC	p.S7243Y		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7245	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGGCTCAGGGAGGAAATTGA	0.468													15	181					2.32078e-09	2.84178e-09	0.003163	1	0
ZNF761	388561	broad.mit.edu	37	19	53958709	53958709	+	Missense_Mutation	SNP	T	A	A			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr19:53958709T>A	uc010eqp.2	+	7	1406	c.948T>A	c.(946-948)CAT>CAA	p.H316Q	ZNF761_uc010ydy.1_Missense_Mutation_p.H262Q|ZNF761_uc002qbt.1_Missense_Mutation_p.H262Q	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	316	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		TTGAAAGACATAGGATAATTC	0.383													86	15					0	0	0.014410	0	0
ZNF761	388561	broad.mit.edu	37	19	53958711	53958711	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr19:53958711G>A	uc010eqp.2	+	7	1408	c.950G>A	c.(949-951)AGG>AAG	p.R317K	ZNF761_uc010ydy.1_Missense_Mutation_p.R263K|ZNF761_uc002qbt.1_Missense_Mutation_p.R263K	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	317	C2H2-type 4.			R -> S (in Ref. 2; BAD18456).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		GAAAGACATAGGATAATTCAT	0.383													88	15					0	0	0.014410	0	0
XPO1	7514	broad.mit.edu	37	2	61709536	61709536	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr2:61709536G>A	uc002sbj.2	-	23	3679	c.2951C>T	c.(2950-2952)TCG>TTG	p.S984L	XPO1_uc010fcl.2_Missense_Mutation_p.S980L|XPO1_uc010ypn.1_Missense_Mutation_p.S980L|XPO1_uc002sbk.2_Missense_Mutation_p.S545L|XPO1_uc002sbg.2_Missense_Mutation_p.S181L|XPO1_uc002sbh.2_Missense_Mutation_p.S631L	NM_003400	NP_003391	O14980	XPO1_HUMAN	exportin 1	984					intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			AGGGAAGGCCGACTTAAGGAG	0.269													8	90					0	0	0.008291	0	0
ANAPC1	64682	broad.mit.edu	37	2	112625621	112625621	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr2:112625621G>C	uc002thi.2	-	7	911	c.664C>G	c.(664-666)CCA>GCA	p.P222A		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	222					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						CAAACAAGTGGAGTTATTTCA	0.328													3	70					0	0	0.004672	0	0
LRP1B	53353	broad.mit.edu	37	2	141643776	141643776	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr2:141643776G>C	uc002tvj.1	-	24	4867	c.3895C>G	c.(3895-3897)CAA>GAA	p.Q1299E	LRP1B_uc010fnl.1_Missense_Mutation_p.Q481E	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1299	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGTAAACTTTGATTGAAGTGA	0.328										TSP Lung(27;0.18)			73	13					0	0	0.014410	0	0
ARL6IP6	151188	broad.mit.edu	37	2	153591621	153591621	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr2:153591621C>T	uc002tyn.2	+	3	1284	c.568C>T	c.(568-570)CTT>TTT	p.L190F	ARL6IP6_uc002tym.2_RNA|ARL6IP6_uc002tyo.2_Missense_Mutation_p.L82F	NM_152522	NP_689735	Q8N6S5	AR6P6_HUMAN	ADP-ribosylation-like factor 6 interacting	190						integral to membrane					0						TCCTACTCCTCTTTCACCTGC	0.378													5	123					0	0	0.014758	0	0
GGTLC1	92086	broad.mit.edu	37	20	23967129	23967129	+	Silent	SNP	C	T	T			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr20:23967129C>T	uc002wts.2	-	2	253	c.120G>A	c.(118-120)CTG>CTA	p.L40L	GGTLC1_uc002wtu.2_Silent_p.L40L	NM_178312	NP_842564	Q9BX51	GGTL1_HUMAN	gamma-glutamyltransferase light chain 1	40							gamma-glutamyltransferase activity			ovary(1)	1						CGACCACAGACAGGTGAGCAG	0.647													52	38					0	0	0.014410	0	0
MATN4	8785	broad.mit.edu	37	20	43927153	43927153	+	Silent	SNP	G	A	A			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr20:43927153G>A	uc002xnn.2	-	7	1270	c.1083C>T	c.(1081-1083)TTC>TTT	p.F361F	MATN4_uc002xno.2_Silent_p.F320F|MATN4_uc002xnp.2_Silent_p.F279F|MATN4_uc010zwr.1_Silent_p.F309F|MATN4_uc002xnr.1_Silent_p.F361F	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	402	VWFA 2.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				TCACTAGCTCGAAGTTTTGTG	0.597													6	198					0	0	0.001984	0	0
MOCS3	27304	broad.mit.edu	37	20	49575760	49575760	+	Silent	SNP	G	T	T			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr20:49575760G>T	uc002xvy.1	+	1	398	c.381G>T	c.(379-381)CTG>CTT	p.L127L	DPM1_uc002xvw.1_5'Flank|DPM1_uc002xvx.1_5'Flank	NM_014484	NP_055299	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	127					enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			skin(2)|ovary(1)	3						GCCAAGTGCTGCATGGCGAGG	0.667													9	242					6.40141e-05	7.53107e-05	0.010729	1	0
TMPRSS15	5651	broad.mit.edu	37	21	19685347	19685347	+	Silent	SNP	T	G	G	rs111276490		TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr21:19685347T>G	uc002ykw.2	-	18	2111	c.2080A>C	c.(2080-2082)AGA>CGA	p.R694R		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	694	Extracellular (Potential).|SRCR.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						CTCTGGATTCTGAACCGCACT	0.279													90	6					0	0	0.014410	0	0
PFKL	5211	broad.mit.edu	37	21	45732008	45732008	+	Silent	SNP	C	T	T	rs140593126	byFrequency	TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr21:45732008C>T	uc002zel.2	+	4	317	c.258C>T	c.(256-258)AGC>AGT	p.S86S	PFKL_uc002zek.2_Silent_p.S133S|PFKL_uc011afd.1_Silent_p.S133S	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	86				S -> T (in Ref. 2; CAB46744).	fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)		TCATTGGCAGCGCTCGCTGCA	0.652													9	0					0	0	0.006214	0	0
Unknown	0	broad.mit.edu	37	22	18844763	18844763	+	RNA	SNP	T	C	C			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr22:18844763T>C	uc002zoe.2	+	4		c.2017T>C			uc002zof.2_5'Flank					Homo sapiens cDNA FLJ76361 complete cds.																		TCACAGCCTCTGAGGGCAGCA	0.562													2	9					0	0	0.004672	0	0
TXNRD2	10587	broad.mit.edu	37	22	19870863	19870863	+	Silent	SNP	A	T	T			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr22:19870863A>T	uc011ahc.1	-	12	1104	c.1071T>A	c.(1069-1071)ATT>ATA	p.I357I	TXNRD2_uc002zql.1_Silent_p.I111I|TXNRD2_uc002zqm.1_RNA|TXNRD2_uc002zqn.1_RNA|TXNRD2_uc002zqo.1_RNA|TXNRD2_uc002zqp.1_RNA|TXNRD2_uc002zqr.1_Silent_p.I356I|TXNRD2_uc002zqj.1_RNA|TXNRD2_uc002zqq.1_5'Flank	NM_006440	NP_006431	Q9NNW7	TRXR2_HUMAN	thioredoxin reductase 2 precursor	357					cell redox homeostasis|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			ovary(2)	2	Colorectal(54;0.0993)					CCACGTCACCAATGGCGTAGA	0.652													64	11					0	0	0.014410	0	0
CCDC116	164592	broad.mit.edu	37	22	21989095	21989095	+	Nonsense_Mutation	SNP	C	G	G			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr22:21989095C>G	uc002zve.2	+	4	836	c.743C>G	c.(742-744)TCA>TGA	p.S248*	CCDC116_uc011aih.1_Nonsense_Mutation_p.S248*	NM_152612	NP_689825	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	248										ovary(1)|skin(1)	2	Colorectal(54;0.105)					CTGCTGGGCTCAAGCTCTGGC	0.577													7	147					0	0	0.001984	0	0
CCR5	1234	broad.mit.edu	37	3	46415326	46415326	+	Silent	SNP	C	T	T			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr3:46415326C>T	uc003cpo.3	+	3	1055	c.933C>T	c.(931-933)TTC>TTT	p.F311F	CCR5_uc010hjd.2_Silent_p.F311F	NM_001100168	NP_001093638	P51681	CCR5_HUMAN	chemokine (C-C motif) receptor 5	311	Cytoplasmic (Potential).				cell-cell signaling|cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|immune response|inflammatory response|initiation of viral infection	endosome|external side of plasma membrane|integral to plasma membrane	actin binding|C-C chemokine receptor activity|coreceptor activity|phosphatidylinositol phospholipase C activity			lung(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)	Maraviroc(DB04835)	TCTTAGTCTTCTTCCAAAAGC	0.502													8	255					0	0	0.003080	0	0
ACTL6A	86	broad.mit.edu	37	3	179304341	179304341	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr3:179304341G>A	uc003fjw.2	+	13	1303	c.1130G>A	c.(1129-1131)CGG>CAG	p.R377Q	ACTL6A_uc003fjx.2_Missense_Mutation_p.R335Q|ACTL6A_uc003fjy.2_Missense_Mutation_p.R335Q	NM_004301	NP_004292	O96019	ACL6A_HUMAN	actin-like 6A isoform 1	377					chromatin remodeling|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|nervous system development|regulation of growth|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	Ino80 complex|npBAF complex|NuA4 histone acetyltransferase complex|plasma membrane|SWI/SNF complex	ATP binding|chromatin binding			ovary(1)	1	all_cancers(143;3.94e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)			CAGAGTATGCGGTTGAAATTG	0.313													41	7					0	0	0.008740	0	0
HAND2	9464	broad.mit.edu	37	4	174449979	174449979	+	Silent	SNP	C	T	T			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr4:174449979C>T	uc003ith.1	-	1	1400	c.462G>A	c.(460-462)CTG>CTA	p.L154L	NBLA00301_uc011ckd.1_5'Flank|NBLA00301_uc003itl.3_5'Flank|NBLA00301_uc003itj.2_5'Flank|NBLA00301_uc010irf.2_5'Flank|NBLA00301_uc010irg.2_5'Flank|NBLA00301_uc010irh.2_5'Flank|NBLA00301_uc010iri.2_5'Flank|NBLA00301_uc010irj.2_5'Flank|NBLA00301_uc010irk.2_5'Flank|NBLA00301_uc010irl.2_5'Flank|NBLA00301_uc010irm.2_5'Flank|NBLA00301_uc010irn.2_5'Flank|NBLA00301_uc003itk.2_5'Flank|HAND2_uc003itg.1_Missense_Mutation_p.A120T|HAND2_uc010ire.1_Silent_p.L154L	NM_021973	NP_068808	P61296	HAND2_HUMAN	basic helix-loop-helix transcription factor	154	Helix-loop-helix motif.				adult heart development|angiogenesis|apoptosis|cardiac neural crest cell development involved in outflow tract morphogenesis|heart looping|in utero embryonic development|negative regulation of cardiac muscle cell apoptosis|noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|regulation of secondary heart field cardioblast proliferation|thymus development	nuclear chromatin|transcription factor complex	activating transcription factor binding|protein homodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|transcription coactivator activity			skin(1)	1		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.37e-18)|Epithelial(43;5.5e-17)|OV - Ovarian serous cystadenocarcinoma(60;3.3e-10)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		CCTTGGCCAGCAGGTCCATGA	0.577													4	73					0	0	0.009096	0	0
KLHL3	26249	broad.mit.edu	37	5	136963990	136963990	+	Silent	SNP	G	A	A			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr5:136963990G>A	uc010jek.2	-	13	2031	c.1587C>T	c.(1585-1587)AAC>AAT	p.N529N	KLHL3_uc011cyc.1_Silent_p.N264N|KLHL3_uc003lbr.3_Silent_p.N447N|KLHL3_uc011cyd.1_RNA	NM_017415	NP_059111	Q9UH77	KLHL3_HUMAN	kelch-like 3	529	Kelch 5.					cytoplasm|cytoskeleton	actin binding|structural molecule activity				0		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		CATTACCTGCGTTGCGCCGGC	0.537													75	133					0	0	0.014410	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140711928	140711928	+	Silent	SNP	G	A	A			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr5:140711928G>A	uc003lji.1	+	1	1677	c.1677G>A	c.(1675-1677)GCG>GCA	p.A559A	PCDHGA1_uc011dan.1_Silent_p.A559A	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	559	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGACAACGCGCCCGAGATCC	0.647													178	187					0	0	0.014410	0	0
DRD1	1812	broad.mit.edu	37	5	174870046	174870046	+	Silent	SNP	G	A	A			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr5:174870046G>A	uc003mcz.2	-	2	1002	c.57C>T	c.(55-57)GAC>GAT	p.D19D		NM_000794	NP_000785	P21728	DRD1_HUMAN	dopamine receptor D1	19	Extracellular (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|adult walking behavior|cerebral cortex GABAergic interneuron migration|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|mating behavior|positive regulation of cAMP biosynthetic process|positive regulation of cell migration|positive regulation of potassium ion transport|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|response to drug|synapse assembly|visual learning	endoplasmic reticulum membrane|membrane fraction	protein binding			ovary(2)|skin(1)	3	all_cancers(89;0.00895)|Renal(175;0.000159)|Lung NSC(126;0.00625)|all_lung(126;0.0104)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)		Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Carphenazine(DB01038)|Chlorprothixene(DB01239)|Clozapine(DB00363)|Cocaine(DB00907)|Dopamine(DB00988)|Fenoldopam(DB00800)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Methylergonovine(DB00353)|Minaprine(DB00805)|Olanzapine(DB00334)|Pegademase bovine(DB00061)|Pergolide(DB01186)|Perphenazine(DB00850)|Prochlorperazine(DB00433)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Triflupromazine(DB00508)|Zuclopenthixol(DB01624)	GAACAGAGAAGTCCCTCTCCA	0.572													59	94					0	0	0.014410	0	0
UBR2	23304	broad.mit.edu	37	6	42657391	42657391	+	Silent	SNP	G	A	A			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr6:42657391G>A	uc011dur.1	+	46	5109	c.5109G>A	c.(5107-5109)GAG>GAA	p.E1703E	UBR2_uc011dus.1_Silent_p.E1348E|UBR2_uc003osh.2_RNA|UBR2_uc011dut.1_Silent_p.E291E|UBR2_uc011duu.1_Silent_p.E95E	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	1703					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			ACTATGGGGAGACCGACCAGG	0.517													314	36					0	0	0.014410	0	0
DOPEY1	23033	broad.mit.edu	37	6	83862077	83862077	+	Silent	SNP	A	G	G			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr6:83862077A>G	uc003pjs.1	+	30	6380	c.6120A>G	c.(6118-6120)TTA>TTG	p.L2040L	DOPEY1_uc011dyy.1_Silent_p.L2031L|DOPEY1_uc010kbl.1_Silent_p.L2031L|DOPEY1_uc003pjt.2_RNA	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	2040					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		CATTGACATTACTCTCTGAGG	0.294													3	54					0	0	0.009096	0	0
USP45	85015	broad.mit.edu	37	6	99930682	99930682	+	Missense_Mutation	SNP	C	A	A			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr6:99930682C>A	uc003ppx.2	-	8	1325	c.792G>T	c.(790-792)GAG>GAT	p.E264D	USP45_uc003ppw.2_Intron|USP45_uc003ppy.2_RNA|USP45_uc010kcq.1_Missense_Mutation_p.E264D|USP45_uc003ppz.2_Missense_Mutation_p.E264D|USP45_uc003pqa.2_Missense_Mutation_p.E264D	NM_001080481	NP_001073950	Q70EL2	UBP45_HUMAN	ubiquitin specific peptidase 45	264					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|breast(1)	2		all_cancers(76;0.000208)|Acute lymphoblastic leukemia(125;8.41e-11)|all_hematologic(75;2.56e-07)|all_epithelial(107;0.122)|Colorectal(196;0.133)		BRCA - Breast invasive adenocarcinoma(108;0.0718)		CTTTTTCAGTCTCCTTCATGC	0.383													70	5					5.98616e-33	7.4827e-33	0.014410	1	0
HOXA5	3202	broad.mit.edu	37	7	27182685	27182685	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr7:27182685C>T	uc003syn.1	-	1	603	c.542G>A	c.(541-543)CGC>CAC	p.R181H		NM_019102	NP_061975	P20719	HXA5_HUMAN	homeobox A5	181	Antp-type hexapeptide.				negative regulation of angiogenesis|negative regulation of erythrocyte differentiation|positive regulation of apoptosis|positive regulation of myeloid cell differentiation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GTGCAGCTTGCGCATCCAGGG	0.677													5	375					0	0	0.014758	0	0
C7orf41	222166	broad.mit.edu	37	7	30197075	30197075	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr7:30197075G>A	uc011kab.1	+	3	508	c.307G>A	c.(307-309)GAT>AAT	p.D103N	C7orf41_uc010kvr.1_RNA|C7orf41_uc003tar.1_Missense_Mutation_p.D103N	NM_152793	NP_690006	Q8N3F0	CG041_HUMAN	hypothetical protein LOC222166	103											0						TCCGGATGCAGATGACGATGC	0.562													6	404					0	0	0.001984	0	0
IRF5	3663	broad.mit.edu	37	7	128587532	128587532	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr7:128587532C>T	uc003vog.2	+	7	821	c.700C>T	c.(700-702)CCC>TCC	p.P234S	IRF5_uc010llr.1_Silent_p.C216C|IRF5_uc010lls.1_Silent_p.C216C|IRF5_uc003voh.2_Missense_Mutation_p.P218S|IRF5_uc010llt.2_Intron|IRF5_uc003voi.2_Missense_Mutation_p.P218S|IRF5_uc010llu.1_Silent_p.C216C|IRF5_uc003vok.2_3'UTR|IRF5_uc003voj.3_Missense_Mutation_p.P218S|IRF5_uc010llv.1_3'UTR|IRF5_uc010llw.1_Silent_p.C216C	NM_002200	NP_002191	Q13568	IRF5_HUMAN	interferon regulatory factor 5 isoform a	228					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						TGCCAGCCTGCCCCCTGCAGG	0.682													18	25					0	0	0.012319	0	0
C8orf34	116328	broad.mit.edu	37	8	69380981	69380981	+	Missense_Mutation	SNP	G	A	A	rs142064557	byFrequency	TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr8:69380981G>A	uc010lyz.2	+	4	453	c.404G>A	c.(403-405)CGT>CAT	p.R135H	C8orf34_uc010lyy.1_Missense_Mutation_p.R135H|C8orf34_uc003xyb.2_Missense_Mutation_p.R110H	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	135					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			CCACAAAGCCGTGATTTTGAT	0.378													80	8					0	0	0.014410	0	0
BAAT	570	broad.mit.edu	37	9	104125282	104125282	+	Missense_Mutation	SNP	C	T	T	rs141722672	by1000genomes	TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr9:104125282C>T	uc010mtd.2	-	4	794	c.685G>A	c.(685-687)GTT>ATT	p.V229I	BAAT_uc004bbd.3_Missense_Mutation_p.V229I	NM_001127610	NP_001121082	Q14032	BAAT_HUMAN	bile acid Coenzyme A: amino acid	229					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			ovary(1)|lung(1)|skin(1)	3		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	ACTACCCCAACGCCTGAGCCA	0.388													23	37					0	0	0.012319	0	0
COL4A6	1288	broad.mit.edu	37	X	107434729	107434729	+	Silent	SNP	T	C	C			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chrX:107434729T>C	uc004enw.3	-	19	1321	c.1218A>G	c.(1216-1218)CCA>CCG	p.P406P	COL4A6_uc004env.3_Silent_p.P405P|COL4A6_uc011msn.1_Silent_p.P405P|COL4A6_uc010npk.2_Silent_p.P405P	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	406	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						CCTTCAGCCCTGGAAATCCCT	0.567									Alport_syndrome_with_Diffuse_Leiomyomatosis				4	192					0	0	0.014758	0	0
SFRS2IP	9169	broad.mit.edu	37	12	46320707	46320708	+	Frame_Shift_Del	DEL	TC	-	-			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr12:46320707_46320708delTC	uc001rox.2	-	11	3063_3064	c.2776_2777delGA	c.(2776-2778)GAAfs	p.E926fs	SFRS2IP_uc001row.2_Frame_Shift_Del_p.E611fs|SFRS2IP_uc001roy.1_Frame_Shift_Del_p.E1000fs	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	926	Arg-rich.				spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		GGTTCTCCTTTCTCTCTCTCTC	0.446													11	502	---	---	---	---					
ACADL	33	broad.mit.edu	37	2	211057526	211057526	+	Splice_Site	DEL	A	-	-			TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr2:211057526delA	uc002vdz.3	-	10	1427	c.1199_splice	c.e10+1	p.K400_splice		NM_001608	NP_001599	P28330	ACADL_HUMAN	long-chain acyl-CoA dehydrogenase precursor						carnitine catabolic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial matrix	long-chain-acyl-CoA dehydrogenase activity|palmitoyl-CoA oxidase activity				0		Renal(323;0.202)		Epithelial(149;0.00631)|Lung(261;0.0438)|LUSC - Lung squamous cell carcinoma(261;0.0466)|all cancers(144;0.0621)		AACTATACTTACTTTGCAATT	0.383													63	4	---	---	---	---					
SETD2	29072	broad.mit.edu	37	3	47162849	47162850	+	Frame_Shift_Del	DEL	TT	-	-	rs114327122	by1000genomes	TCGA-BQ-5891-01A-11D-1589-08	TCGA-BQ-5891-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	37d4ff42-0161-4f83-bd6f-13eb19d4eabf	28824279-2be9-45db-867a-b165d8191d0c	g.chr3:47162849_47162850delTT	uc003cqs.2	-	3	3329_3330	c.3276_3277delAA	c.(3274-3279)CAAAGTfs	p.Q1092fs	SETD2_uc003cqv.2_Frame_Shift_Del_p.Q1081fs	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1092_1093					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TGTCTATAACTTTGACTGCTCC	0.416			N|F|S|Mis		clear cell renal carcinoma								121	20	---	---	---	---					
