Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TAS1R3	83756	broad.mit.edu	37	1	1269265	1269265	+	Silent	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr1:1269265G>A	uc010nyk.1	+	6	1980	c.1980G>A	c.(1978-1980)GTG>GTA	p.V660V		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	660	Helical; Name=3; (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	AGATCTTCGTGGAGTCAGAAC	0.582000													8	20					0	0	0.000274275	0	0
EPHA8	2046	broad.mit.edu	37	1	22902942	22902942	+	Missense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr1:22902942G>A	uc001bfx.1	+	3	517	c.392G>A	c.(391-393)CGC>CAC	p.R131H	EPHA8_uc001bfw.2_Missense_Mutation_p.R131H	NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	131	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GAGTCGGACCGCGACCTGGGG	0.587000													21	26					0	0	0.000175454	0	0
KDM4A	9682	broad.mit.edu	37	1	44169937	44169937	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr1:44169937A>G	uc001cjx.2	+	22	3257	c.3091A>G	c.(3091-3093)ACA>GCA	p.T1031A	uc001cjy.2_Intron|ST3GAL3_uc009vwu.1_5'Flank|KDM4A_uc010oki.1_3'UTR	NM_014663	NP_055478	O75164	KDM4A_HUMAN	jumonji domain containing 2A	1031					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1						TGAGATTTTCACAGAGAAAGA	0.438000													4	165					0	0	0.00024832	0	0
SLC6A9	6536	broad.mit.edu	37	1	44467233	44467233	+	Silent	SNP	G	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr1:44467233G>C	uc001cll.2	-	9	1440	c.1248C>G	c.(1246-1248)TCC>TCG	p.S416S	SLC6A9_uc009vxe.2_Silent_p.S272S|SLC6A9_uc010okm.1_Silent_p.S343S|SLC6A9_uc001clm.2_Silent_p.S362S|SLC6A9_uc009vxd.2_RNA|SLC6A9_uc010okn.1_Silent_p.S347S|SLC6A9_uc001cln.2_Silent_p.S343S|SLC6A9_uc010oko.1_Silent_p.S232S|SLC6A9_uc010okp.1_RNA	NM_201649	NP_964012	P48067	SC6A9_HUMAN	solute carrier family 6 member 9 isoform 2	416	Helical; Name=7; (Potential).					integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity				0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	AGCCGAGGATGGAGAAGATGA	0.597000													4	99					0	0	0.00024832	0	0
FGGY	55277	broad.mit.edu	37	1	59812021	59812021	+	Missense_Mutation	SNP	G	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr1:59812021G>C	uc001czi.3	+	4	628	c.416G>C	c.(415-417)GGG>GCG	p.G139A	FGGY_uc001czg.2_Missense_Mutation_p.G27A|FGGY_uc001czh.2_RNA|FGGY_uc009wac.2_Missense_Mutation_p.G139A|FGGY_uc001czj.3_Missense_Mutation_p.G139A|FGGY_uc001czk.3_Missense_Mutation_p.G27A|FGGY_uc001czl.3_Intron	NM_018291	NP_060761	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	139					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(1)	1	all_cancers(7;7.36e-05)					TACGTCGGGGGGGTGATGTCT	0.502000													3	41					0	0	0.00024832	0	0
NBPF14	25832	broad.mit.edu	37	1	148009508	148009509	+	Missense_Mutation	DNP	CC	AA	AA	rs143363070	by1000genomes	TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr1:148009508_148009509CC>AA	uc001eqq.2	-	16	1815_1816	c.1798_1799GG>TT	c.(1798-1800)GGG>TTG	p.G600L	LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqf.2_Intron|LOC200030_uc001eqg.2_Intron|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Missense_Mutation_p.G173L|NBPF14_uc001eqx.2_Intron|NBPF14_uc010pad.1_Intron|NBPF14_uc001eqs.1_Intron	NM_015383	NP_056198	Q5TI25	NBPFE_HUMAN	hypothetical protein LOC25832	600	NBPF 7.					cytoplasm				ovary(1)	1	all_hematologic(923;0.032)					CAACAGCTCCCCGCTGAGCCTG	0.465000													11	283					0	0	6.4e-05	0	0
PSMB4	5692	broad.mit.edu	37	1	151372078	151372078	+	Silent	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr1:151372078G>A	uc001eyc.1	+	1	38	c.15G>A	c.(13-15)TTG>TTA	p.L5L	PSMB4_uc010pda.1_Silent_p.L5L|PSMB4_uc001eyb.1_Silent_p.L5L	NM_002796	NP_002787	P28070	PSB4_HUMAN	proteasome beta 4 subunit	5					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			ovary(2)	2	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			AAGCGTTTTTGGGGTCGCGGT	0.542000													41	59					0	0	0.000147903	0	0
C1orf66	51093	broad.mit.edu	37	1	156705540	156705540	+	Missense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr1:156705540G>A	uc001fpu.2	+	7	1779	c.1145G>A	c.(1144-1146)CGA>CAA	p.R382Q	C1orf66_uc001fpv.2_Silent_p.A220A	NM_015997	NP_057081	Q96FB5	RRNAD_HUMAN	hypothetical protein LOC51093 isoform 1	382						integral to membrane	rRNA (adenine-N6,N6-)-dimethyltransferase activity				0	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGGCTACAGCGAGTGGGGCTA	0.547000													28	31					0	0	7.24521e-05	0	0
INSRR	3645	broad.mit.edu	37	1	156823725	156823725	+	Silent	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr1:156823725G>A	uc010pht.1	-	2	710	c.456C>T	c.(454-456)ACC>ACT	p.T152T	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron|INSRR_uc009wsj.1_Silent_p.T152T	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	152					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCCAGTCAATGGTGGAGAGGT	0.642000													5	10					0	0	1.23904e-05	0	0
PLEKHA6	22874	broad.mit.edu	37	1	204226699	204226699	+	Missense_Mutation	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr1:204226699C>T	uc001hau.2	-	9	1623	c.1306G>A	c.(1306-1308)GAG>AAG	p.E436K	PLEKHA6_uc009xaw.1_Missense_Mutation_p.E60K|PLEKHA6_uc009xax.1_Missense_Mutation_p.E60K|PLEKHA6_uc009xay.1_Missense_Mutation_p.E60K|PLEKHA6_uc009xaz.1_Missense_Mutation_p.E60K|PLEKHA6_uc009xba.1_Missense_Mutation_p.E60K|PLEKHA6_uc009xbb.1_Missense_Mutation_p.E60K|PLEKHA6_uc009xbc.1_Missense_Mutation_p.E60K	NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	436										ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			GCATCCAGCTCATCATAATAG	0.687000													9	6					0	0	6.40141e-05	0	0
KCNH1	3756	broad.mit.edu	37	1	211192165	211192165	+	Missense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr1:211192165G>A	uc001hib.2	-	6	1162	c.992C>T	c.(991-993)GCT>GTT	p.A331V	KCNH1_uc001hic.2_Intron	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	331	Extracellular (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		AATCTGATCAGCAAAACCAAT	0.448000													47	90					0	0	0.000147903	0	0
SPATA17	128153	broad.mit.edu	37	1	217975148	217975148	+	Nonsense_Mutation	SNP	G	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr1:217975148G>T	uc001hlh.1	+	9	987	c.961G>T	c.(961-963)GAA>TAA	p.E321*	SPATA17_uc001hli.2_Nonsense_Mutation_p.E321*	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	321						cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		TTCTTACAAAGAACAATTCCG	0.294000													24	29					4.4004e-07	2.0276e-05	5.49717e-05	1	0
OBSCN	84033	broad.mit.edu	37	1	228494234	228494234	+	Missense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr1:228494234G>A	uc009xez.1	+	44	11865	c.11821G>A	c.(11821-11823)GGC>AGC	p.G3941S	OBSCN_uc001hsn.2_Missense_Mutation_p.G3941S	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3941	Ig-like 40.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				ACGGCTTCAGGGCTGCACCGC	0.632000													25	21					0	0	0.000147802	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	Missense_Mutation	SNP	A	G	G	rs2257765		TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr10:38654432A>G	uc010qex.1	+	5	599	c.524A>G	c.(523-525)AAT>AGT	p.N175S	HSD17B7P2_uc001izq.2_RNA|HSD17B7P2_uc001izo.1_RNA|HSD17B7P2_uc001izp.1_Missense_Mutation_p.N173S					SubName: Full=cDNA FLJ60462, highly similar to 3-keto-steroid reductase (EC 1.1.1.270);												0						TCATCTCGCAATGCAAGGAAA	0.453000													4	82					0	0	0.00024832	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72503320	72503320	+	Missense_Mutation	SNP	G	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr10:72503320G>T	uc001jrh.2	+	13	1941	c.1941G>T	c.(1939-1941)GAG>GAT	p.E647D	ADAMTS14_uc001jrg.2_Missense_Mutation_p.E650D|ADAMTS14_uc001jri.1_Missense_Mutation_p.E170D	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	647	Cys-rich.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						AGAAGTGTGAGCTGATCTGCC	0.597000													15	25					6.81908e-15	3.29533e-13	0.000219431	1	0
CPEB3	22849	broad.mit.edu	37	10	93812079	93812079	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr10:93812079A>G	uc001khw.1	-	10	2160	c.1987T>C	c.(1987-1989)TGT>CGT	p.C663R	CPEB3_uc001khu.1_Missense_Mutation_p.C672R|CPEB3_uc001khv.1_Missense_Mutation_p.C649R|CPEB3_uc010qnn.1_Missense_Mutation_p.C649R	NM_014912	NP_055727	Q8NE35	CPEB3_HUMAN	cytoplasmic polyadenylation element binding	663							nucleotide binding|RNA binding				0		Colorectal(252;0.0869)				CAGTATTCACAGTAATACTGC	0.592000													16	20					0	0	0.000308642	0	0
KNDC1	85442	broad.mit.edu	37	10	135012252	135012252	+	Missense_Mutation	SNP	G	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr10:135012252G>C	uc001llz.1	+	14	2241	c.2240G>C	c.(2239-2241)GGG>GCG	p.G747A	KNDC1_uc001lma.1_Missense_Mutation_p.G682A|KNDC1_uc001lmb.1_Missense_Mutation_p.G159A	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	747	Pro-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GAGCCTCTTGGGGCGTCAGTG	0.726000													3	2					0	0	6.4e-05	0	0
HARBI1	283254	broad.mit.edu	37	11	46637368	46637368	+	Silent	SNP	C	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr11:46637368C>A	uc001ncy.2	-	2	668	c.420G>T	c.(418-420)GGG>GGT	p.G140G	KIAA0652_uc009yld.2_5'Flank|KIAA0652_uc001nda.2_5'Flank|KIAA0652_uc001ndb.2_5'Flank|KIAA0652_uc001ncz.2_5'Flank|KIAA0652_uc001ndc.2_5'Flank|KIAA0652_uc010rgv.1_5'Flank	NM_173811	NP_776172	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	140						cytoplasm|nucleus	metal ion binding|nuclease activity				0						CCCCTGGCATCCCTGCCAACC	0.512000													63	117					7.1157e-29	3.64618e-27	0.000147903	1	0
SAPS3	55291	broad.mit.edu	37	11	68377390	68377390	+	Silent	SNP	T	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr11:68377390T>A	uc001onw.2	+	23	2736	c.2469T>A	c.(2467-2469)TCT>TCA	p.S823S	SAPS3_uc001onv.2_Silent_p.S829S|SAPS3_uc001ony.3_Silent_p.S794S|SAPS3_uc001onx.2_Silent_p.S817S|SAPS3_uc009ysh.2_Silent_p.S743S|SAPS3_uc001onu.2_Silent_p.S743S|SAPS3_uc010rqc.1_Silent_p.S591S|SAPS3_uc010rqd.1_Silent_p.S506S|SAPS3_uc001onz.2_Silent_p.S151S|SAPS3_uc001ooa.2_Silent_p.S279S	NM_001164161	NP_001157633	Q5H9R7	PP6R3_HUMAN	SAPS domain family, member 3 isoform 6	823					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)			GGAAACTGTCTACCTCTCAAG	0.577000													51	64					0	0	0.000147903	0	0
ANKK1	255239	broad.mit.edu	37	11	113270078	113270078	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr11:113270078A>G	uc001pny.2	+	8	1481	c.1387A>G	c.(1387-1389)ACC>GCC	p.T463A		NM_178510	NP_848605	Q8NFD2	ANKK1_HUMAN	ankyrin repeat and kinase domain containing 1	463	ANK 4.						ATP binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|ovary(1)|breast(1)	8		all_cancers(61;1.53e-11)|all_epithelial(67;3e-06)|Melanoma(852;4.04e-05)|all_hematologic(158;0.000315)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0461)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Prostate(24;0.194)		BRCA - Breast invasive adenocarcinoma(274;4.82e-06)|Epithelial(105;5.41e-05)|all cancers(92;0.000442)|OV - Ovarian serous cystadenocarcinoma(223;0.238)		TGAAGGGTGGACCCCTCTTCA	0.622000													3	6					0	0	6.4e-05	0	0
PEX5	5830	broad.mit.edu	37	12	7343122	7343122	+	Splice_Site	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr12:7343122T>C	uc009zfu.1	+	3	727	c.147_splice	c.e3+2	p.A49_splice	PEX5_uc001qsw.2_Splice_Site_p.A49_splice|PEX5_uc010sgc.1_Missense_Mutation_p.V50A|PEX5_uc001qsu.2_Splice_Site_p.A49_splice|PEX5_uc010sgd.1_Splice_Site_p.A70_splice|PEX5_uc001qsv.2_Splice_Site_p.A49_splice	NM_001131026	NP_001124498	P50542	PEX5_HUMAN	peroxisomal biogenesis factor 5 isoform d						protein import into peroxisome matrix, translocation|protein targeting to peroxisome|protein tetramerization|protein transport	cytosol|peroxisomal matrix|peroxisomal membrane	peroxisome matrix targeting signal-1 binding|protein C-terminus binding|protein N-terminus binding			ovary(1)	1						TCTGAGGCAGTGAGTGTTCTT	0.632000													10	10					0	0	3.86212e-05	0	0
LOC653113	653113	broad.mit.edu	37	12	8384412	8384412	+	RNA	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr12:8384412G>A	uc010sgk.1	-	5		c.1376C>T				NR_024254				Homo sapiens family with sequence similarity 86, member A pseudogene (LOC653113), non-coding RNA.												0						TGTCCTTCCCGCAGCTTCTTC	0.582000													7	36					0	0	3.86212e-05	0	0
GSG1	83445	broad.mit.edu	37	12	13243503	13243503	+	Missense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr12:13243503G>A	uc001rbn.2	-	2	471	c.298C>T	c.(298-300)CGG>TGG	p.R100W	GSG1_uc001rbj.2_Missense_Mutation_p.R87W|GSG1_uc001rbk.2_Missense_Mutation_p.R87W|GSG1_uc001rbl.2_Missense_Mutation_p.R87W|GSG1_uc001rbm.2_Missense_Mutation_p.R87W|GSG1_uc001rbo.2_Missense_Mutation_p.R100W|GSG1_uc001rbp.2_Missense_Mutation_p.R100W|GSG1_uc001rbq.1_Missense_Mutation_p.R100W	NM_001080555	NP_001074024	Q2KHT4	GSG1_HUMAN	germ cell associated 1 isoform 4	87						endoplasmic reticulum membrane|integral to membrane					0		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		AAGGAGAACCGGTCATCCCCA	0.542000													6	117					0	0	0.000274275	0	0
IPO8	10526	broad.mit.edu	37	12	30790088	30790088	+	Silent	SNP	C	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr12:30790088C>G	uc001rjd.2	-	22	2693	c.2523G>C	c.(2521-2523)CTG>CTC	p.L841L	IPO8_uc001rje.1_Silent_p.L330L|IPO8_uc010sjt.1_Silent_p.L636L	NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	841					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					AAAGGATACTCAGTCCTATTA	0.393000													67	41					0	0	0.000147903	0	0
FAM60A	58516	broad.mit.edu	37	12	31435663	31435663	+	Missense_Mutation	SNP	A	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr12:31435663A>C	uc010sjz.1	-	6	888	c.649T>G	c.(649-651)TCC>GCC	p.S217A	FAM60A_uc001rkd.2_Missense_Mutation_p.S217A|FAM60A_uc010ska.1_Missense_Mutation_p.S217A|FAM60A_uc001rke.2_Missense_Mutation_p.S217A|FAM60A_uc010skb.1_RNA|FAM60A_uc001rkc.2_Missense_Mutation_p.S242A	NM_021238	NP_067061	Q9NP50	FA60A_HUMAN	family with sequence similarity 60, member A	217											0	all_cancers(9;5.22e-13)|all_epithelial(9;4e-13)|all_lung(12;1.2e-11)|Lung NSC(12;2.17e-09)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0207)|Lung SC(12;0.0592)|Esophageal squamous(101;0.162)					TCCTGAGTGGAGATGGGCAGA	0.453000													44	32					0	0	0.000147903	0	0
KRT83	3889	broad.mit.edu	37	12	52708468	52708468	+	Missense_Mutation	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr12:52708468C>T	uc001saf.2	-	9	1492	c.1429G>A	c.(1429-1431)GGC>AGC	p.G477S		NM_002282	NP_002273	P78385	KRT83_HUMAN	keratin 83	477	Tail.				epidermis development	keratin filament	structural molecule activity			skin(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TTCAGCTGGCCACAGGGCTTG	0.667000													5	7					0	0	1.23904e-05	0	0
HSP90B1	7184	broad.mit.edu	37	12	104336447	104336447	+	Missense_Mutation	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr12:104336447T>C	uc001tkb.1	+	12	1622	c.1517T>C	c.(1516-1518)CTT>CCT	p.L506P	HSP90B1_uc010swg.1_Missense_Mutation_p.L171P|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	506					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	CGAACACGTCTTGCTAAACTT	0.373000													79	51					0	0	0.000147903	0	0
MYO1H	283446	broad.mit.edu	37	12	109834250	109834250	+	Missense_Mutation	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr12:109834250C>T	uc010sxn.1	+	3	304	c.304C>T	c.(304-306)CTC>TTC	p.L102F		NM_001101421	NP_001094891	Q8N1T3	MYO1H_HUMAN	myosin 1H	Error:Variant_position_missing_in_B4DNW6_after_alignment						myosin complex	motor activity				0						CCATTTCATCCTCATTTCTGG	0.458000													39	33					0	0	0.000374591	0	0
NCOR2	9612	broad.mit.edu	37	12	124848291	124848291	+	Silent	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr12:124848291A>G	uc010tba.1	-	21	2979	c.2862T>C	c.(2860-2862)AAT>AAC	p.N954N	NCOR2_uc010tay.1_Silent_p.N954N|NCOR2_uc010taz.1_Silent_p.N937N|NCOR2_uc010tbb.1_Silent_p.N954N|NCOR2_uc010tbc.1_Silent_p.N936N|NCOR2_uc001ugj.1_Silent_p.N954N	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	954					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GGGGTGAGGCATTGGCCCGGG	0.697000													66	58					0	0	0.000147903	0	0
EP400	57634	broad.mit.edu	37	12	132522561	132522562	+	Missense_Mutation	DNP	GC	AT	AT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr12:132522561_132522562GC>AT	uc001ujn.2	+	31	6162_6163	c.6127_6128GC>AT	c.(6127-6129)GCT>ATT	p.A2043I	EP400_uc001ujl.2_Missense_Mutation_p.A2042I|EP400_uc001ujm.2_Missense_Mutation_p.A1962I	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2079					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CCCGGTCAAAGCTGAGGAGTTT	0.465000													53	148					0	0	6.4e-05	0	0
KBTBD6	89890	broad.mit.edu	37	13	41704906	41704906	+	Missense_Mutation	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr13:41704906T>C	uc001uxu.1	-	1	2031	c.1742A>G	c.(1741-1743)AAC>AGC	p.N581S	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Missense_Mutation_p.N515S|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	581	Kelch 5.						protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		AGTCACCCGGTTCTTTTTCCA	0.408000													119	78					0	0	0.000147903	0	0
LRCH1	23143	broad.mit.edu	37	13	47315858	47315859	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr13:47315858_47315859GG>TT	uc001vbj.2	+	19	2298_2299	c.2062_2063GG>TT	c.(2062-2064)GGG>TTG	p.G688L	LRCH1_uc001vbk.2_Missense_Mutation_p.G723L|LRCH1_uc001vbl.3_Intron	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	688	CH.									ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		GCTGGCACTCGGGGAGAAAGCC	0.515000													12	509					0	0	6.4e-05	0	0
NALCN	259232	broad.mit.edu	37	13	101944368	101944368	+	Missense_Mutation	SNP	G	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr13:101944368G>T	uc001vox.1	-	9	1209	c.1020C>A	c.(1018-1020)AGC>AGA	p.S340R	NALCN_uc001voy.2_Missense_Mutation_p.S55R|NALCN_uc001voz.2_Missense_Mutation_p.S340R|NALCN_uc001vpa.2_Missense_Mutation_p.S340R	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	340	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AGGTAGTGCTGCTTCTCGATC	0.438000													26	17					5.77227e-19	2.8592e-17	0.000227799	1	0
SIPA1L1	26037	broad.mit.edu	37	14	72055716	72055716	+	Missense_Mutation	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr14:72055716T>C	uc001xms.2	+	2	1475	c.1127T>C	c.(1126-1128)CTG>CCG	p.L376P	SIPA1L1_uc001xmt.2_Missense_Mutation_p.L376P|SIPA1L1_uc001xmu.2_Missense_Mutation_p.L376P|SIPA1L1_uc001xmv.2_Missense_Mutation_p.L376P	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	376					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		TCTGGACCTCTGTCTCATTCA	0.498000													20	38					0	0	0.000295444	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72055734	72055734	+	Missense_Mutation	SNP	T	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr14:72055734T>A	uc001xms.2	+	2	1493	c.1145T>A	c.(1144-1146)TTT>TAT	p.F382Y	SIPA1L1_uc001xmt.2_Missense_Mutation_p.F382Y|SIPA1L1_uc001xmu.2_Missense_Mutation_p.F382Y|SIPA1L1_uc001xmv.2_Missense_Mutation_p.F382Y	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	382					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		TCAGCCAGTTTTAGCTCCCCA	0.507000													17	34					0	0	5.01169e-05	0	0
THBS1	7057	broad.mit.edu	37	15	39885267	39885267	+	Missense_Mutation	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr15:39885267T>C	uc001zkh.2	+	18	3013	c.2834T>C	c.(2833-2835)ATC>ACC	p.I945T	THBS1_uc010bbi.2_Missense_Mutation_p.I417T	NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	945	TSP type-3 8.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	ATCGATGACATCTGTCCTGAG	0.478000													25	30					0	0	0.000184323	0	0
EPB42	2038	broad.mit.edu	37	15	43508525	43508525	+	Missense_Mutation	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr15:43508525C>T	uc001zra.3	-	2	437	c.137G>A	c.(136-138)CGC>CAC	p.R46H	EPB42_uc010bde.2_5'UTR|EPB42_uc001zrb.3_Missense_Mutation_p.R76H|EPB42_uc010udm.1_Missense_Mutation_p.R46H	NM_001114134	NP_001107606	P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2 isoform 2	46					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			ovary(2)	2		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		GACTGGAGCGCGGAAGTACAG	0.597000													26	34					0	0	0.000184323	0	0
Unknown	0	broad.mit.edu	37	15	76074693	76074693	+	Missense_Mutation	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr15:76074693C>T	uc010umm.1	+	9	765	c.688C>T	c.(688-690)CGG>TGG	p.R230W	uc002bba.1_5'Flank					SubName: Full=cDNA FLJ59077, highly similar to Golgin subfamily A member 6;																		AGAGAGGGCCCGGTGGCAGGA	0.403000													35	32					0	0	0.000106405	0	0
HMG20A	10363	broad.mit.edu	37	15	77756662	77756662	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr15:77756662A>G	uc002bcr.2	+	4	371	c.170A>G	c.(169-171)CAA>CGA	p.Q57R	HMG20A_uc002bcq.1_Missense_Mutation_p.Q57R|HMG20A_uc002bcs.2_Missense_Mutation_p.Q57R	NM_018200	NP_060670	Q9NP66	HM20A_HUMAN	high-mobility group 20A	57					chromatin modification	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						GATCTCTCTCAAGGTCAGTTG	0.448000													32	43					0	0	7.24521e-05	0	0
TSC2	7249	broad.mit.edu	37	16	2130345	2130345	+	Missense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr16:2130345G>A	uc002con.2	+	30	3683	c.3577G>A	c.(3577-3579)GGC>AGC	p.G1193S	TSC2_uc010bsd.2_Missense_Mutation_p.G1193S|TSC2_uc002coo.2_Missense_Mutation_p.G1149S|TSC2_uc010uvv.1_Missense_Mutation_p.G1113S|TSC2_uc010uvw.1_Missense_Mutation_p.G1101S|TSC2_uc002cop.2_Missense_Mutation_p.G949S|TSC2_uc002coq.2_5'Flank|TSC2_uc002cor.2_5'Flank	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	1193					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				GCTGACCCAGGGCTGGGCGGA	0.662000			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				22	60					0	0	0.000375601	0	0
PDXDC1	23042	broad.mit.edu	37	16	15127233	15127234	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr16:15127233_15127234CG>AT	uc002dda.3	+	19	2013_2014	c.1789_1790CG>AT	c.(1789-1791)CGG>ATG	p.R597M	PDXDC1_uc010uzl.1_Missense_Mutation_p.R582M|PDXDC1_uc010uzm.1_Missense_Mutation_p.R506M|PDXDC1_uc002ddb.3_Missense_Mutation_p.R570M|PDXDC1_uc010uzn.1_Missense_Mutation_p.R569M|PDXDC1_uc002ddc.2_Intron	NM_015027	NP_055842	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain	597					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	GGCCACAGCCCGGGAGATAGAG	0.564000													5	150					0	0	6.4e-05	0	0
LOC81691	81691	broad.mit.edu	37	16	20851091	20851091	+	Silent	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr16:20851091C>T	uc002dhv.2	+	14	1661	c.1398C>T	c.(1396-1398)GCC>GCT	p.A466A	ERI2_uc002dht.3_Intron|LOC81691_uc002dhx.2_Silent_p.A466A|LOC81691_uc002dhw.2_Silent_p.A209A|LOC81691_uc002dhy.3_Silent_p.A466A	NM_030941	NP_112203	Q96IC2	REXON_HUMAN	exonuclease NEF-sp isoform 1	466						nucleolus	exonuclease activity|nucleotide binding|RNA binding			ovary(1)|kidney(1)	2						TTGAGCAGGCCAGAGTGGAAA	0.448000													242	149					0	0	0.000147903	0	0
HYDIN	54768	broad.mit.edu	37	16	70843785	70843786	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr16:70843785_70843786CG>AT	uc002ezr.2	-	85	14908_14909	c.14780_14781CG>AT	c.(14779-14781)CCG>CAT	p.P4927H	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4928										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CAGGCTTTTCCGGAAGTGCTGG	0.485000													15	560					0	0	6.4e-05	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2908679	2908680	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr17:2908679_2908680GG>TT	uc010ckd.2	+	15	1307_1308	c.1217_1218GG>TT	c.(1216-1218)CGG>CTT	p.R406L	RAP1GAP2_uc010cke.2_Missense_Mutation_p.R391L	NM_015085	NP_055900	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2 isoform 1	406	Rap-GAP.				regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			ovary(1)	1						GTCACTGCGCGGGAAGATGTGC	0.594000													7	221					0	0	6.4e-05	0	0
DULLARD	23399	broad.mit.edu	37	17	7149598	7149598	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr17:7149598A>G	uc002gfd.2	-	5	832	c.452T>C	c.(451-453)ATT>ACT	p.I151T	DULLARD_uc002gfe.2_Missense_Mutation_p.I151T|DULLARD_uc002gff.2_Missense_Mutation_p.I151T|DULLARD_uc002gfc.2_RNA	NM_001143775	NP_001137247	O95476	CNEP1_HUMAN	dullard homolog	151	FCP1 homology.				nuclear envelope organization|protein dephosphorylation	endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein serine/threonine phosphatase activity				0						CCTCTTAAGAATGCTTCTGCT	0.498000													33	89					0	0	0.000132358	0	0
DNAH9	1770	broad.mit.edu	37	17	11687648	11687649	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr17:11687648_11687649CG>AT	uc002gne.2	+	41	7921_7922	c.7853_7854CG>AT	c.(7852-7854)CCG>CAT	p.P2618H	DNAH9_uc010coo.2_Missense_Mutation_p.P1912H	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2618	AAA 3 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CTCTCCTTCCCGGGGGCAGATG	0.530000													8	344					0	0	6.4e-05	0	0
NCOR1	9611	broad.mit.edu	37	17	16089949	16089949	+	Nonsense_Mutation	SNP	G	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr17:16089949G>C	uc002gpo.2	-	3	401	c.161C>G	c.(160-162)TCA>TGA	p.S54*	NCOR1_uc002gpn.2_Nonsense_Mutation_p.S54*|NCOR1_uc002gpp.1_Intron|NCOR1_uc002gpr.2_Intron|NCOR1_uc002gps.1_Nonsense_Mutation_p.S54*|NCOR1_uc010coz.1_Translation_Start_Site|NCOR1_uc010cpb.1_Nonsense_Mutation_p.S54*|NCOR1_uc010cpa.1_Nonsense_Mutation_p.S54*|NCOR1_uc002gpu.2_Nonsense_Mutation_p.S54*	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	54	Interaction with ZBTB33 and HEXIM1.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CAAAAGCTGTGATGCCTGACT	0.403000													28	57					0	0	0.000117367	0	0
SRCIN1	80725	broad.mit.edu	37	17	36708962	36708962	+	Missense_Mutation	SNP	C	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr17:36708962C>G	uc002hqd.2	-	12	2556	c.2331G>C	c.(2329-2331)AAG>AAC	p.K777N	SRCIN1_uc002hqf.1_Missense_Mutation_p.K649N|SRCIN1_uc002hqe.2_Missense_Mutation_p.K631N|SRCIN1_uc002hqg.2_Missense_Mutation_p.K83N	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	649	Potential.				exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0						CAGACCCACCCTTGAGCTCTG	0.632000													26	48					0	0	0.000184323	0	0
CASC3	22794	broad.mit.edu	37	17	38319005	38319005	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr17:38319005G>A	uc010cwt.1	+	6	931	c.636G>A	c.(634-636)TGG>TGA	p.W212*	CASC3_uc010cws.1_Nonsense_Mutation_p.W212*|CASC3_uc002hue.2_Nonsense_Mutation_p.W212*	NM_007359	NP_031385	O15234	CASC3_HUMAN	metastatic lymph node 51	212	Necessary for RNA-binding, interaction with MAGOH and localization in nucleus speckles.|Sufficient to form the EJC.				mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			ovary(1)	1						GAAAGCTATGGAAGGATGAGG	0.493000													12	39					0	0	6.40141e-05	0	0
MPO	4353	broad.mit.edu	37	17	56348163	56348163	+	Missense_Mutation	SNP	A	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr17:56348163A>T	uc002ivu.1	-	12	2269	c.2092T>A	c.(2092-2094)TCA>ACA	p.S698T		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	698					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	CGGGGCAATGAGATCTGGGCC	0.547000													46	26					0	0	0.000147903	0	0
INTS2	57508	broad.mit.edu	37	17	59981846	59981846	+	Missense_Mutation	SNP	G	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr17:59981846G>T	uc002izn.2	-	9	1382	c.1306C>A	c.(1306-1308)CTA>ATA	p.L436I	INTS2_uc002izm.2_Missense_Mutation_p.L428I	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	436	Helical; (Potential).				snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						AAGGCCAGTAGCATACAAAAG	0.403000													16	9					4.7546e-09	2.2253e-07	0.000422831	1	0
PIP5K1C	23396	broad.mit.edu	37	19	3648675	3648675	+	Missense_Mutation	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr19:3648675C>T	uc002lyj.1	-	9	1216	c.1159G>A	c.(1159-1161)GGG>AGG	p.G387R	PIP5K1C_uc010xhq.1_Missense_Mutation_p.G387R|PIP5K1C_uc010xhr.1_Missense_Mutation_p.G387R	NM_012398	NP_036530	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	387	PIPK.				axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			stomach(2)|skin(2)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		AGCCGCTCCCCGCGGCCGTTC	0.692000													20	17					0	0	0.000295444	0	0
APBA3	9546	broad.mit.edu	37	19	3760228	3760228	+	Missense_Mutation	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr19:3760228C>T	uc002lyp.1	-	2	212	c.35G>A	c.(34-36)GGG>GAG	p.G12E	MRPL54_uc002lyq.3_5'Flank	NM_004886	NP_004877	O96018	APBA3_HUMAN	amyloid beta (A4) precursor protein-binding,	12					intracellular signal transduction|protein transport	intracellular|membrane	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCTGGAGGCCCCGAAGGGGA	0.622000													8	11					0	0	0.000157383	0	0
ZNF626	199777	broad.mit.edu	37	19	20807769	20807769	+	Missense_Mutation	SNP	A	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr19:20807769A>C	uc002npb.1	-	4	1064	c.914T>G	c.(913-915)ATA>AGA	p.I305R	ZNF626_uc002npc.1_Missense_Mutation_p.I229R	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	305	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						AGTATGAATTATCTTATGTGT	0.363000													3	78					0	0	0.00024832	0	0
PSMD8	5714	broad.mit.edu	37	19	38874011	38874011	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr19:38874011A>G	uc002oii.3	+	7	1086	c.1034A>G	c.(1033-1035)CAG>CGG	p.Q345R		NM_002812	NP_002803	P48556	PSMD8_HUMAN	proteasome 26S non-ATPase subunit 8	345					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome regulatory particle	protein binding			central_nervous_system(1)	1	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TATGCCCGGCAGCTGGAGATG	0.557000													7	15					0	0	0.000157383	0	0
ZNF180	7733	broad.mit.edu	37	19	44981073	44981073	+	Missense_Mutation	SNP	G	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr19:44981073G>C	uc002ozf.3	-	5	1907	c.1625C>G	c.(1624-1626)ACT>AGT	p.T542S	ZNF180_uc002ozh.3_Missense_Mutation_p.T199S|ZNF180_uc002ozi.3_Missense_Mutation_p.T515S|ZNF180_uc002ozg.3_Missense_Mutation_p.T541S|ZNF180_uc010ejm.2_Missense_Mutation_p.T517S	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	542	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				TCCAGTGTGAGTTCTTTGATG	0.423000													29	48					0	0	0.000184323	0	0
RSPH6A	81492	broad.mit.edu	37	19	46317979	46317979	+	Silent	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr19:46317979G>A	uc002pdm.2	-	1	599	c.456C>T	c.(454-456)TAC>TAT	p.Y152Y		NM_030785	NP_110412	Q9H0K4	RSH6A_HUMAN	radial spokehead-like 1	152						intracellular				ovary(1)|central_nervous_system(1)	2						GGTCTGTCTGGTAGAGGTTGA	0.602000													12	33					0	0	6.40141e-05	0	0
LILRA3	11026	broad.mit.edu	37	19	54803120	54803120	+	Missense_Mutation	SNP	G	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr19:54803120G>T	uc002qfd.2	-	4	622	c.557C>A	c.(556-558)CCC>CAC	p.P186H	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Intron	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	186	Ig-like C2-type 2.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGGGCTCACGGGGCCCACGGA	0.587000													36	51					4.62619e-21	2.31076e-19	0.000132358	1	0
ZNF324B	388569	broad.mit.edu	37	19	58966903	58966903	+	Missense_Mutation	SNP	T	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr19:58966903T>A	uc002qsv.1	+	4	699	c.592T>A	c.(592-594)TGT>AGT	p.C198S	ZNF324B_uc002qsu.1_Missense_Mutation_p.C188S|ZNF324B_uc010euq.1_Missense_Mutation_p.C198S	NM_207395	NP_997278	Q6AW86	Z324B_HUMAN	zinc finger protein 324B	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		GCAGAAGCCATGTGCACAGGA	0.672000													16	23					0	0	0.000422831	0	0
PAPOLG	64895	broad.mit.edu	37	2	61009021	61009021	+	Missense_Mutation	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr2:61009021T>C	uc002sai.2	+	11	1139	c.908T>C	c.(907-909)GTA>GCA	p.V303A	PAPOLG_uc002saj.2_5'UTR|PAPOLG_uc002sak.2_5'UTR|PAPOLG_uc010fch.2_5'UTR	NM_022894	NP_075045	Q9BWT3	PAPOG_HUMAN	poly(A) polymerase gamma	303					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(2;0.0797)		LUSC - Lung squamous cell carcinoma(5;1.19e-07)|Lung(5;2.86e-06)|Epithelial(17;0.0768)			ATTTCACAGGTAAATCCATCA	0.358000													3	116					0	0	0.00024832	0	0
TGFA	7039	broad.mit.edu	37	2	70742029	70742029	+	Missense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr2:70742029G>A	uc002sgs.3	-	2	262	c.56C>T	c.(55-57)GCG>GTG	p.A19V	TGFA_uc010fdq.2_Missense_Mutation_p.A25V|TGFA_uc010fdr.2_Missense_Mutation_p.A25V|TGFA_uc002sgt.3_Missense_Mutation_p.A19V|TGFA_uc002sgu.2_Missense_Mutation_p.A19V|TGFA_uc002sgv.2_Missense_Mutation_p.A19V|TGFA_uc002sgw.2_Missense_Mutation_p.A19V	NM_003236	NP_003227	P01135	TGFA_HUMAN	transforming growth factor, alpha isoform 1	19					activation of MAPK activity|cell proliferation|positive regulation of cell division|positive regulation of epidermal growth factor receptor activity|positive regulation of epithelial cell proliferation|positive regulation of mitosis	cell surface|extracellular space|integral to membrane|plasma membrane	epidermal growth factor receptor binding|growth factor activity|MAP kinase kinase activity|signal transducer activity			prostate(1)	1						GGCCTGGCACGCAGCCAACAC	0.597000													21	22					0	0	0.000295444	0	0
DCTN1	1639	broad.mit.edu	37	2	74597431	74597431	+	Missense_Mutation	SNP	T	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr2:74597431T>A	uc002skx.2	-	12	1480	c.1169A>T	c.(1168-1170)AAG>ATG	p.K390M	DCTN1_uc002skv.2_Missense_Mutation_p.K256M|DCTN1_uc002sku.2_Missense_Mutation_p.K256M|DCTN1_uc002skw.1_Missense_Mutation_p.K366M|DCTN1_uc010ffd.2_Missense_Mutation_p.K370M|DCTN1_uc002sky.2_Missense_Mutation_p.K353M	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	390	Potential.				cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5						CTTCTGGAGCTTCACATGCTC	0.547000													19	41					0	0	0.000175454	0	0
MAP4K4	9448	broad.mit.edu	37	2	102493544	102493544	+	Silent	SNP	C	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr2:102493544C>A	uc002tbg.2	+	24	2941	c.2886C>A	c.(2884-2886)ATC>ATA	p.I962I	MAP4K4_uc002tbc.2_Silent_p.I1043I|MAP4K4_uc002tbd.2_Silent_p.I935I|MAP4K4_uc002tbe.2_Silent_p.I881I|MAP4K4_uc002tbf.2_Silent_p.I996I|MAP4K4_uc010yvy.1_Silent_p.I958I|MAP4K4_uc002tbh.2_Silent_p.I880I|MAP4K4_uc002tbi.2_Silent_p.I765I|MAP4K4_uc010yvz.1_Silent_p.I1002I|MAP4K4_uc002tbk.2_Silent_p.I417I|MAP4K4_uc002tbl.2_Silent_p.I148I	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	962	CNH.|Mediates interaction with RAP2A.				intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4						ATCCTCTTATCAACCGAAGAC	0.453000													49	31					9.58827e-17	4.67153e-15	0.000147903	1	0
UPP2	151531	broad.mit.edu	37	2	158971732	158971732	+	Silent	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr2:158971732A>G	uc002tzp.2	+	3	494	c.300A>G	c.(298-300)AGA>AGG	p.R100R	UPP2_uc002tzo.2_Silent_p.R157R	NM_173355	NP_775491	O95045	UPP2_HUMAN	uridine phosphorylase 2 isoform a	100					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity				0						GGACAGACAGATACTGTATGT	0.458000													33	74					0	0	7.24521e-05	0	0
TTN	7273	broad.mit.edu	37	2	179468605	179468605	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr2:179468605A>G	uc010zfg.1	-	231	47329	c.47105T>C	c.(47104-47106)ATA>ACA	p.I15702T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.I9397T|TTN_uc010zfi.1_Missense_Mutation_p.I9330T|TTN_uc010zfj.1_Missense_Mutation_p.I9205T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16629							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATACTTACATATGGGATCTCC	0.398000													25	50					0	0	5.49717e-05	0	0
RPL37A	6168	broad.mit.edu	37	2	217364692	217364692	+	Silent	SNP	T	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr2:217364692T>A	uc002vgf.2	+	3	231	c.153T>A	c.(151-153)GCT>GCA	p.A51A	RPL37A_uc002vgg.2_Silent_p.A51A	NM_000998	NP_000989	P61513	RL37A_HUMAN	ribosomal protein L37a	51	C4-type.				endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	metal ion binding|protein binding|structural constituent of ribosome			ovary(1)	1		Renal(323;0.0458)		Epithelial(149;3.51e-06)|all cancers(144;0.000249)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGAGACGAGCTGTGGGGATCT	0.443000													70	62					0	0	0.000147903	0	0
COL4A3	1285	broad.mit.edu	37	2	228118302	228118303	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr2:228118302_228118303CG>AT	uc002vom.1	+	13	875_876	c.713_714CG>AT	c.(712-714)CCG>CAT	p.P238H	COL4A3_uc002von.1_Missense_Mutation_p.P238H|COL4A3_uc002voo.1_Missense_Mutation_p.P238H|COL4A3_uc002vop.1_Missense_Mutation_p.P238H|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	238	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		ACAGGACCCCCGGGACCACCAG	0.436000													9	275					0	0	6.4e-05	0	0
SP110	3431	broad.mit.edu	37	2	231077477	231077477	+	Silent	SNP	T	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr2:231077477T>G	uc002vqh.3	-	4	822	c.582A>C	c.(580-582)TCA>TCC	p.S194S	SP110_uc002vqg.3_Silent_p.S194S|SP110_uc002vqi.3_Silent_p.S194S|SP110_uc010fxk.2_Silent_p.S194S	NM_004509	NP_004500	Q9HB58	SP110_HUMAN	SP110 nuclear body protein isoform a	194					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			ovary(2)|breast(2)	4		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		GTTTCTCACCTGAAGTGCTTC	0.532000													129	107					0	0	0.000147903	0	0
MMP24	10893	broad.mit.edu	37	20	33851638	33851638	+	Missense_Mutation	SNP	C	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr20:33851638C>A	uc002xbu.2	+	5	865	c.862C>A	c.(862-864)CTG>ATG	p.L288M	EDEM2_uc010zuv.1_Intron	NM_006690	NP_006681	Q9Y5R2	MMP24_HUMAN	matrix metalloproteinase 24 preproprotein	288	Extracellular (Potential).				proteolysis	integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GGGCCACGCGCTGGGACTGGA	0.627000													6	5					1.6384e-10	7.79092e-09	8.12818e-05	1	0
EPB41L1	2036	broad.mit.edu	37	20	34800245	34800245	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr20:34800245A>G	uc002xfb.2	+	16	2302	c.2131A>G	c.(2131-2133)ATT>GTT	p.I711V	EPB41L1_uc002xeu.2_Missense_Mutation_p.I637V|EPB41L1_uc010zvo.1_Missense_Mutation_p.I711V|EPB41L1_uc002xev.2_Missense_Mutation_p.I711V|EPB41L1_uc002xew.2_Missense_Mutation_p.I602V|EPB41L1_uc002xex.2_Missense_Mutation_p.I531V|EPB41L1_uc002xey.2_Missense_Mutation_p.I489V|EPB41L1_uc002xez.2_Missense_Mutation_p.I637V|EPB41L1_uc010gfq.2_Missense_Mutation_p.I810V	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	711					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					TAGAAAGAAGATTGAGCCGGA	0.493000													26	52					0	0	0.000184323	0	0
NPEPL1	79716	broad.mit.edu	37	20	57276200	57276200	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr20:57276200A>G	uc010zzs.1	+	6	903	c.808A>G	c.(808-810)AGC>GGC	p.S270G	NPEPL1_uc010zzr.1_Missense_Mutation_p.S222G|NPEPL1_uc002xzn.2_RNA|NPEPL1_uc010gjo.1_Missense_Mutation_p.S242G|NPEPL1_uc002xzp.2_Missense_Mutation_p.S158G	NM_024663	NP_078939	Q8NDH3	PEPL1_HUMAN	aminopeptidase-like 1	270					proteolysis	cytoplasm	aminopeptidase activity|manganese ion binding|metalloexopeptidase activity				0	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;2.88e-09)|Colorectal(105;0.109)			TGGAGGCCTCAGCATCAAAGG	0.677000													4	3					0	0	0.00024832	0	0
NRIP1	8204	broad.mit.edu	37	21	16338944	16338944	+	Missense_Mutation	SNP	T	C	C	rs149069507	byFrequency	TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr21:16338944T>C	uc002yjx.2	-	4	2168	c.1570A>G	c.(1570-1572)AAT>GAT	p.N524D		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	524	Repression domain 2.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		CTCACATCATTGTGTACTCCC	0.403000													93	137					0	0	0.000147903	0	0
SETD4	54093	broad.mit.edu	37	21	37410517	37410517	+	Missense_Mutation	SNP	C	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr21:37410517C>G	uc002yuw.1	-	9	2492	c.1119G>C	c.(1117-1119)AAG>AAC	p.K373N	SETD4_uc002yux.1_Missense_Mutation_p.K349N|SETD4_uc002yuu.2_RNA|SETD4_uc002yuv.2_Missense_Mutation_p.K373N	NM_017438	NP_059134	Q9NVD3	SETD4_HUMAN	SET domain containing 4 isoform a	373				EILVKYLPSTDKQMDKKISILKDHGYIENLTFGWDGPSWRL LTALKLLCLEAEKFTCWKKVLLGEVISDTNEKTSLDIAQKI CYYFIEETNAVLQKVSHMKDEKEALINQLTLVESLWTEELK ILRASAETLHSLQTAFT -> GWNQLCS (in Ref. 5; AAH02898).						large_intestine(1)|ovary(1)	2						CCAAACTTGTCTTCTCATTCG	0.353000													54	60					0	0	0.000147903	0	0
CERK	64781	broad.mit.edu	37	22	47108141	47108141	+	Missense_Mutation	SNP	T	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr22:47108141T>G	uc003bia.2	-	4	536	c.429A>C	c.(427-429)AAA>AAC	p.K143N	CERK_uc010hae.2_5'UTR	NM_022766	NP_073603	Q8TCT0	CERK1_HUMAN	ceramide kinase	143	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|ceramide metabolic process	integral to membrane of membrane fraction|membrane|nucleus	ATP binding|ceramide kinase activity|diacylglycerol kinase activity|magnesium ion binding			skin(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TGCCTTGTCCTTTTCCTCCAA	0.388000													19	36					0	0	0.000295444	0	0
FGD5	152273	broad.mit.edu	37	3	14862878	14862879	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr3:14862878_14862879CC>AA	uc003bzc.2	+	1	2410_2411	c.2300_2301CC>AA	c.(2299-2301)CCC>CAA	p.P767Q	FGD5_uc011avk.1_Missense_Mutation_p.P767Q	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	767					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						ATCTCCTTCCCCAGCGCTGACA	0.594000													11	306					0	0	6.4e-05	0	0
NBEAL2	23218	broad.mit.edu	37	3	47049869	47049869	+	Missense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr3:47049869G>A	uc003cqp.2	+	51	7995	c.7816G>A	c.(7816-7818)GCA>ACA	p.A2606T	NBEAL2_uc010hjm.1_Missense_Mutation_p.A1983T|NBEAL2_uc010hjn.1_Missense_Mutation_p.A972T|NBEAL2_uc010hjo.1_Missense_Mutation_p.A166T	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	2606							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		TTTCCACCTGGCATTGGGGTC	0.597000													23	15					0	0	0.000295444	0	0
NICN1	84276	broad.mit.edu	37	3	49463424	49463424	+	Silent	SNP	C	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr3:49463424C>G	uc003cwz.1	-	3	400	c.315G>C	c.(313-315)CTG>CTC	p.L105L	NICN1_uc003cxa.2_RNA|NICN1_uc011bcr.1_Intron	NM_032316	NP_115692	Q9BSH3	NICN1_HUMAN	nicolin 1	105						microtubule|nucleus					0				BRCA - Breast invasive adenocarcinoma(193;4.52e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CCATGTCACACAGCATCTGAC	0.567000													11	23					0	0	6.40141e-05	0	0
SFMBT1	51460	broad.mit.edu	37	3	52988412	52988412	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr3:52988412A>G	uc003dgf.2	-	4	613	c.44T>C	c.(43-45)ATG>ACG	p.M15T	SFMBT1_uc003dgg.2_Missense_Mutation_p.M15T|SFMBT1_uc003dgh.2_Missense_Mutation_p.M15T	NM_001005159	NP_001005159	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	15					regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		TACCTCTTCCATACCAGAGCC	0.333000													105	74					0	0	0.000147903	0	0
LRIG1	26018	broad.mit.edu	37	3	66460690	66460690	+	Silent	SNP	C	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr3:66460690C>A	uc003dmx.2	-	7	812	c.798G>T	c.(796-798)CTG>CTT	p.L266L	LRIG1_uc010hnz.2_Silent_p.L6L|LRIG1_uc010hoa.2_Silent_p.L266L	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	266	Extracellular (Potential).|LRR 9.					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		TGTTGTACTCCAGGTGCCTGC	0.567000													8	236					0.000157383	0.00714112	0.000157383	1	0
ZBTB11	27107	broad.mit.edu	37	3	101390027	101390027	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr3:101390027A>G	uc003dve.3	-	3	955	c.725T>C	c.(724-726)CTT>CCT	p.L242P	ZBTB11_uc003dvf.2_3'UTR	NM_014415	NP_055230	O95625	ZBT11_HUMAN	zinc finger protein ZNF-U69274	242	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						CTCAATAAAAAGATCTCGAAA	0.363000													24	58					0	0	5.49717e-05	0	0
DRD3	1814	broad.mit.edu	37	3	113847594	113847595	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr3:113847594_113847595CG>AT	uc003ebd.2	-	8	1594_1595	c.1171_1172CG>AT	c.(1171-1173)CGG>ATG	p.R391M	DRD3_uc010hqn.1_Missense_Mutation_p.R391M|DRD3_uc003ebb.1_Missense_Mutation_p.R358M|DRD3_uc003ebc.1_Missense_Mutation_p.R391M	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	391	Cytoplasmic.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	GAAGGCTTTCCGGAACTCGATA	0.530000													9	477					0	0	6.4e-05	0	0
DIRC2	84925	broad.mit.edu	37	3	122598138	122598139	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr3:122598138_122598139CG>AT	uc003efw.3	+	9	1489_1490	c.1350_1351CG>AT	c.(1348-1353)CCCGGG>CCATGG	p.G451W	DIRC2_uc010hrl.2_RNA|DIRC2_uc010hrm.2_Missense_Mutation_p.G289W|uc003efx.1_RNA	NM_032839	NP_116228	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	451	Helical; (Potential).				transport	integral to membrane					0				GBM - Glioblastoma multiforme(114;0.0614)		GGTGCCTTCCCGGGTCGTGTTT	0.455000													16	580					0	0	6.4e-05	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133692538	133692538	+	Silent	SNP	G	C	C	rs150677069		TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr3:133692538G>C	uc003eqa.3	-	3	640	c.366C>G	c.(364-366)TCC>TCG	p.S122S	SLCO2A1_uc003eqb.3_Silent_p.S122S|SLCO2A1_uc011blv.1_Silent_p.S122S|SLCO2A1_uc010htw.1_5'UTR	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	122	Helical; Name=3; (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						GGTAGGGCTCGGAGAGGAAGT	0.582000													8	19					0	0	0.000274275	0	0
ATP13A3	79572	broad.mit.edu	37	3	194146121	194146121	+	Missense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr3:194146121G>A	uc003fty.3	-	29	3665	c.3263C>T	c.(3262-3264)GCA>GTA	p.A1088V	ATP13A3_uc003ftx.3_5'UTR	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	1088	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		AAAGGCAATTGCCACTATGAG	0.353000													47	40					0	0	0.000147903	0	0
ZBTB49	166793	broad.mit.edu	37	4	4322599	4322599	+	Silent	SNP	C	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr4:4322599C>A	uc003ghu.2	+	8	2029	c.1854C>A	c.(1852-1854)TCC>TCA	p.S618S	uc003ghw.2_5'Flank|ZBTB49_uc003ghv.2_Silent_p.S101S|ZBTB49_uc010icy.2_RNA|ZBTB49_uc010icz.2_Silent_p.S196S	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	zinc finger protein 509	618					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						ACTCTTTCTCCCAAGACACGT	0.547000													19	17					4.96729e-08	2.30669e-06	0.000132079	1	0
CCKAR	886	broad.mit.edu	37	4	26483517	26483517	+	Missense_Mutation	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr4:26483517C>T	uc003gse.1	-	5	1183	c.1030G>A	c.(1030-1032)GAG>AAG	p.E344K		NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor	344	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	AGGCGGCGCTCTGCGGAGGCG	0.592000													30	36					0	0	0.000184323	0	0
ANXA3	306	broad.mit.edu	37	4	79516549	79516549	+	Silent	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr4:79516549A>G	uc003hld.2	+	8	808	c.498A>G	c.(496-498)GAA>GAG	p.E166E	ANXA3_uc003hle.2_Silent_p.E127E|ANXA3_uc010ijk.2_Silent_p.E127E	NM_005139	NP_005130	P12429	ANXA3_HUMAN	annexin A3	166					defense response to bacterium|neutrophil degranulation|phagocytosis|positive regulation of angiogenesis|positive regulation of endothelial cell migration|positive regulation of sequence-specific DNA binding transcription factor activity	phagocytic vesicle membrane|plasma membrane|specific granule	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity				0						GAAGAGATGAAAGTCTGAAAG	0.443000													71	127					0	0	0.000147903	0	0
PLRG1	5356	broad.mit.edu	37	4	155470082	155470082	+	Silent	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr4:155470082T>C	uc003iny.2	-	2	78	c.15A>G	c.(13-15)GTA>GTG	p.V5V	PLRG1_uc003inz.2_Silent_p.V5V|PLRG1_uc011cil.1_5'UTR	NM_002669	NP_002660	O43660	PLRG1_HUMAN	pleiotropic regulator 1 (PRL1 homolog,	5						catalytic step 2 spliceosome|nuclear speck	protein binding|signal transducer activity|transcription corepressor activity				0	all_hematologic(180;0.215)	Renal(120;0.0854)				AATGTTTCTGTACCTCCTAAA	0.353000													11	18					0	0	3.86212e-05	0	0
SLC6A18	348932	broad.mit.edu	37	5	1225707	1225707	+	Missense_Mutation	SNP	G	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr5:1225707G>C	uc003jby.1	+	1	238	c.115G>C	c.(115-117)GGG>CGG	p.G39R		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	39	Helical; Name=1; (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CGTGGGACTGGGGAACATTTG	0.642000													4	19					0	0	0.000375601	0	0
TMEM167A	153339	broad.mit.edu	37	5	82357708	82357708	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr5:82357708A>G	uc003khx.3	-	3	266	c.136T>C	c.(136-138)TGT>CGT	p.C46R		NM_174909	NP_777569	Q8TBQ9	KISHA_HUMAN	transmembrane protein 167A precursor	46	Extracellular (Potential).					Golgi membrane|integral to membrane					0						ATTCTGGCACACTTCCAAAAT	0.313000													25	23					0	0	0.000117367	0	0
PCSK1	5122	broad.mit.edu	37	5	95728748	95728748	+	Missense_Mutation	SNP	C	T	T	rs140941383		TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr5:95728748C>T	uc003kls.1	-	14	2425	c.2219G>A	c.(2218-2220)CGG>CAG	p.R740Q	PCSK1_uc010jbi.1_Missense_Mutation_p.R430Q	NM_000439	NP_000430	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	740	Amphipathic (Potential).				cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			ovary(2)	2		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTGAAGCAGCCGGTCGTCTCT	0.398000													91	112					0	0	0.000147903	0	0
CHD1	1105	broad.mit.edu	37	5	98236974	98236974	+	Missense_Mutation	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr5:98236974T>C	uc003knf.2	-	5	651	c.503A>G	c.(502-504)GAA>GGA	p.E168G		NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	168					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	CTCTCTCTCTTCTTCAGATTC	0.358000													60	64					0	0	0.000147903	0	0
GTF2H4	2968	broad.mit.edu	37	6	30877829	30877829	+	Silent	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr6:30877829C>T	uc003nsa.1	+	4	570	c.363C>T	c.(361-363)GCC>GCT	p.A121A	GTF2H4_uc010jsf.2_Silent_p.A121A|GTF2H4_uc011dmv.1_Silent_p.A65A|GTF2H4_uc003nsb.1_5'UTR|GTF2H4_uc011dmw.1_Silent_p.A127A	NM_001517	NP_001508	Q92759	TF2H4_HUMAN	general transcription factor IIH, polypeptide 4,	121					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3						TCCGCATTGCCCTTCTGGGTG	0.582000								NER					45	57					0	0	0.000147903	0	0
VARS2	57176	broad.mit.edu	37	6	30883015	30883015	+	Splice_Site	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr6:30883015G>A	uc003nsc.1	+	2	915	c.283_splice	c.e2+1	p.D95_splice	VARS2_uc003nsd.2_Splice_Site_p.D95_splice|VARS2_uc011dmx.1_Splice_Site_p.D95_splice|VARS2_uc011dmy.1_Splice_Site|VARS2_uc011dmz.1_Splice_Site_p.D125_splice|VARS2_uc011dna.1_Splice_Site_p.D95_splice|VARS2_uc011dnb.1_Splice_Site|VARS2_uc011dnc.1_Splice_Site	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial						valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4						GAAAAGAAAGGTAAGTAGAAT	0.453000													45	40					0	0	0.000437636	0	0
HLA-DQA2	3118	broad.mit.edu	37	6	32714066	32714066	+	Silent	SNP	C	T	T	rs143176293		TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr6:32714066C>T	uc003obx.2	+	4	721	c.663C>T	c.(661-663)TGC>TGT	p.C221C		NM_020056	NP_064440	P01906	DQA2_HUMAN	major histocompatibility complex, class II, DQ	221	Helical; (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTTTGGTCTGCGCCCTGGGGT	0.552000													62	70					0	0	0.000147903	0	0
SCUBE3	222663	broad.mit.edu	37	6	35199528	35199528	+	Missense_Mutation	SNP	G	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr6:35199528G>T	uc003okf.1	+	4	367	c.361G>T	c.(361-363)GGC>TGC	p.G121C	SCUBE3_uc003okg.1_Missense_Mutation_p.G121C|SCUBE3_uc003okh.1_5'UTR	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	121	EGF-like 3; calcium-binding (Potential).				protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						CGAGGGCAACGGCGGCTGTCA	0.582000													16	18					1.02788e-11	4.92721e-10	5.01169e-05	1	0
CDC5L	988	broad.mit.edu	37	6	44390515	44390515	+	Missense_Mutation	SNP	A	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr6:44390515A>T	uc003oxl.2	+	10	1632	c.1373A>T	c.(1372-1374)GAC>GTC	p.D458V		NM_001253	NP_001244	Q99459	CDC5L_HUMAN	CDC5-like	458	Interaction with PPP1R8.				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			lung(3)|ovary(1)|kidney(1)|skin(1)	6	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GGAATGGCAGACTATAGTGAT	0.383000													56	72					0	0	0.000147903	0	0
PLEKHG1	57480	broad.mit.edu	37	6	151151821	151151821	+	Missense_Mutation	SNP	C	T	T	rs138970683	by1000genomes	TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr6:151151821C>T	uc003qny.1	+	16	1886	c.1574C>T	c.(1573-1575)GCG>GTG	p.A525V	PLEKHG1_uc011eel.1_Missense_Mutation_p.A565V|PLEKHG1_uc011eem.1_Missense_Mutation_p.A584V|PLEKHG1_uc003qnz.2_Missense_Mutation_p.A525V	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	525					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		GTGCTTCGAGCGGGTGGAGCT	0.547000													11	22					0	0	3.86212e-05	0	0
SYNE1	23345	broad.mit.edu	37	6	152671451	152671451	+	Missense_Mutation	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr6:152671451T>C	uc010kiw.2	-	72	12355	c.11753A>G	c.(11752-11754)GAG>GGG	p.E3918G	SYNE1_uc003qot.3_Intron|SYNE1_uc003qou.3_Missense_Mutation_p.E3918G|SYNE1_uc010kja.1_Missense_Mutation_p.E623G	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3918	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GACTTTCGCCTCCAGACTGAA	0.473000										HNSCC(10;0.0054)			18	48					0	0	0.000175454	0	0
ARID1B	57492	broad.mit.edu	37	6	157527600	157527600	+	Silent	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr6:157527600G>A	uc003qqn.2	+	20	5423	c.5271G>A	c.(5269-5271)AAG>AAA	p.K1757K	ARID1B_uc003qqo.2_Silent_p.K1717K|ARID1B_uc003qqp.2_Silent_p.K1704K	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1762					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CAGACCCAAAGGAGAAGCCCA	0.517000													40	60					0	0	0.000228196	0	0
GPNMB	10457	broad.mit.edu	37	7	23296573	23296574	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr7:23296573_23296574GG>TT	uc003swc.2	+	4	591_592	c.430_431GG>TT	c.(430-432)GGG>TTG	p.G144L	GPNMB_uc003swa.2_Missense_Mutation_p.G144L|GPNMB_uc003swb.2_Missense_Mutation_p.G144L|GPNMB_uc011jyy.1_Intron|GPNMB_uc011jyz.1_Missense_Mutation_p.G45L	NM_001005340	NP_001005340	Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb isoform a	144	Extracellular (Potential).				negative regulation of cell proliferation	melanosome				ovary(3)|breast(2)	5			GBM - Glioblastoma multiforme(13;0.154)			GGACAGTGACGGGGAAAATGGC	0.480000													5	116					0	0	6.4e-05	0	0
TMEM120A	83862	broad.mit.edu	37	7	75617587	75617587	+	Silent	SNP	G	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr7:75617587G>T	uc003ued.2	-	7	650	c.546C>A	c.(544-546)CTC>CTA	p.L182L	TMEM120A_uc003uee.2_Silent_p.L86L|TMEM120A_uc003ueb.1_5'Flank|TMEM120A_uc003uec.2_Silent_p.L86L	NM_031925	NP_114131	Q9BXJ8	T120A_HUMAN	transmembrane protein 120A	182	Helical; (Potential).					integral to membrane					0						CGTTGTTGATGAGGATGCTCT	0.657000													36	53					6.03168e-27	3.03833e-25	0.000159656	1	0
ZAN	7455	broad.mit.edu	37	7	100349824	100349824	+	Missense_Mutation	SNP	C	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr7:100349824C>A	uc003uwj.2	+	14	2261	c.2096C>A	c.(2095-2097)TCC>TAC	p.S699Y	ZAN_uc003uwk.2_Missense_Mutation_p.S699Y|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	699	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCCACCATCTCCATGGAAGAG	0.512000													43	56					2.37825e-27	1.20823e-25	8.96297e-05	1	0
MUC17	140453	broad.mit.edu	37	7	100677147	100677148	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr7:100677147_100677148CG>AT	uc003uxp.1	+	3	2503_2504	c.2450_2451CG>AT	c.(2449-2451)CCG>CAT	p.P817H	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	817	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|11.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AGCATCACACCGGTGACCAGTC	0.490000													14	578					0	0	6.4e-05	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117431770	117431771	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr7:117431770_117431771GG>TT	uc003vjf.2	-	4	1571_1572	c.1479_1480CC>AA	c.(1477-1482)ACCCAA>ACAAAA	p.Q494K		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	494	Pro-rich.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GACAGTGCTTGGGTCACAGTAT	0.535000													11	545					0	0	6.4e-05	0	0
NRF1	4899	broad.mit.edu	37	7	129348936	129348937	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr7:129348936_129348937CC>AA	uc003voz.2	+	6	745_746	c.628_629CC>AA	c.(628-630)CCA>AAA	p.P210K	NRF1_uc003vpa.2_Missense_Mutation_p.P210K|NRF1_uc011kpa.1_Missense_Mutation_p.P49K|NRF1_uc003vpb.2_Missense_Mutation_p.P210K	NM_005011	NP_005002	Q16656	NRF1_HUMAN	nuclear respiratory factor 1	210					generation of precursor metabolites and energy|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						GGCATTTATCCCAGAGATGCTC	0.490000													13	678					0	0	6.4e-05	0	0
BRAF	673	broad.mit.edu	37	7	140434424	140434425	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr7:140434424_140434425CC>AA	uc003vwc.3	-	18	2334_2335	c.2273_2274GG>TT	c.(2272-2274)GGG>GTT	p.G758V		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	758					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	CACCATATCCCCCTGCCTGGAT	0.436000		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				15	680					0	0	6.4e-05	0	0
Unknown	0	broad.mit.edu	37	7	142498828	142498828	+	RNA	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr7:142498828C>T	uc011ksh.1	+	3		c.207C>T			uc011ksi.1_RNA|uc003vzw.1_RNA|uc010loj.1_RNA|uc003wad.2_RNA|uc003wag.1_3'UTR|uc003wbe.3_RNA|uc003wbf.3_RNA|uc003wbg.3_RNA|uc003wbh.3_Silent_p.G81G|uc003wbi.3_RNA|uc003wbj.3_RNA|uc003wbm.3_RNA|uc003wbn.3_RNA|uc010los.2_RNA					Homo sapiens mRNA for T-cell receptor beta chain, partial cds, clone:TCRVB.3.																		TGGCCACAGGCTTCTACCCCG	0.617000													39	116					0	0	0.000125731	0	0
EPHB6	2051	broad.mit.edu	37	7	142566068	142566068	+	Missense_Mutation	SNP	G	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr7:142566068G>C	uc011kst.1	+	14	2775	c.1988G>C	c.(1987-1989)CGG>CCG	p.R663P	EPHB6_uc011ksu.1_Missense_Mutation_p.R663P|EPHB6_uc003wbs.2_Missense_Mutation_p.R371P|EPHB6_uc003wbt.2_Missense_Mutation_p.R137P|EPHB6_uc003wbu.2_Missense_Mutation_p.R371P|EPHB6_uc003wbv.2_Missense_Mutation_p.R47P	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	663	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity	p.R648L(1)		lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					GAACTTGCCCGGGAAGTCGAT	0.577000													3	94					0	0	6.4e-05	0	0
ANGPT2	285	broad.mit.edu	37	8	6360731	6360731	+	Missense_Mutation	SNP	G	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr8:6360731G>T	uc003wqj.3	-	9	1711	c.1382C>A	c.(1381-1383)CCA>CAA	p.P461Q	MCPH1_uc003wqi.2_Intron|ANGPT2_uc003wqk.3_Missense_Mutation_p.P460Q|ANGPT2_uc010lri.2_Missense_Mutation_p.P409Q	NM_001147	NP_001138	O15123	ANGP2_HUMAN	angiopoietin 2 isoform a precursor	461	Fibrinogen C-terminal.				angiogenesis|blood coagulation|leukocyte migration|negative regulation of blood vessel endothelial cell migration|negative regulation of positive chemotaxis|Tie receptor signaling pathway	extracellular space	metal ion binding|receptor tyrosine kinase binding			upper_aerodigestive_tract(1)	1		Hepatocellular(245;0.0663)		Colorectal(4;0.0142)|READ - Rectum adenocarcinoma(4;0.19)|COAD - Colon adenocarcinoma(4;0.226)		CTGCCTCTGTGGATAGTACAT	0.463000													22	34					2.27731e-05	0.00104125	0.000229342	1	0
BIN3	55909	broad.mit.edu	37	8	22488017	22488017	+	Silent	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr8:22488017G>A	uc003xcl.2	-	5	332	c.235C>T	c.(235-237)CTG>TTG	p.L79L	BIN3_uc003xck.2_Silent_p.L31L|BIN3_uc010ltw.2_Silent_p.L25L	NM_018688	NP_061158	Q9NQY0	BIN3_HUMAN	bridging integrator 3	79	BAR.				actin filament organization|barrier septum formation|cell cycle|protein localization|unidimensional cell growth	cytoplasm|cytoskeleton	cytoskeletal adaptor activity				0		Prostate(55;0.0424)|Breast(100;0.102)|all_epithelial(46;0.143)		BRCA - Breast invasive adenocarcinoma(99;0.00664)|Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)		ACCATGTTCAGAAGGTCCTGG	0.532000													58	82					0	0	0.000147903	0	0
PROSC	11212	broad.mit.edu	37	8	37633451	37633452	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr8:37633451_37633452CG>AT	uc003xkh.2	+	7	690_691	c.613_614CG>AT	c.(613-615)CGG>ATG	p.R205M		NM_007198	NP_009129	O94903	PROSC_HUMAN	proline synthetase co-transcribed homolog	205							pyridoxal phosphate binding			central_nervous_system(1)	1		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)		L-Proline(DB00172)|Pyridoxal Phosphate(DB00114)	ATTGTCCCTCCGGGAGGAGCTG	0.510000													8	167					0	0	6.4e-05	0	0
FABP12	646486	broad.mit.edu	37	8	82441686	82441686	+	Missense_Mutation	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr8:82441686C>T	uc011lfp.1	-	2	233	c.233G>A	c.(232-234)GGC>GAC	p.G78D	FABP12_uc003ycg.3_RNA	NM_001105281	NP_001098751	A6NFH5	FBP12_HUMAN	fatty acid binding protein 12	78							lipid binding|transporter activity				0						TGTTTTGTGGCCACCTGGCGT	0.388000													70	108					0	0	0.000147903	0	0
RIPK2	8767	broad.mit.edu	37	8	90798839	90798839	+	Missense_Mutation	SNP	C	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr8:90798839C>G	uc003yee.2	+	9	1362	c.1048C>G	c.(1048-1050)CAG>GAG	p.Q350E	RIPK2_uc003yef.2_Missense_Mutation_p.Q213E	NM_003821	NP_003812	O43353	RIPK2_HUMAN	receptor-interacting serine-threonine kinase 2	350					activation of MAPK activity|anti-apoptosis|apoptosis|inflammatory response|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|CARD domain binding|LIM domain binding|protein homodimerization activity|protein serine/threonine kinase activity|signal transducer activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.0474)			TGGATCCTCTCAGCTCCATGA	0.323000													3	104					0	0	6.4e-05	0	0
PTPRD	5789	broad.mit.edu	37	9	8471073	8471073	+	Missense_Mutation	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr9:8471073T>C	uc003zkk.2	-	30	4137	c.3426A>G	c.(3424-3426)ATA>ATG	p.I1142M	PTPRD_uc003zkp.2_Missense_Mutation_p.I731M|PTPRD_uc003zkq.2_Missense_Mutation_p.I731M|PTPRD_uc003zkr.2_Missense_Mutation_p.I726M|PTPRD_uc003zks.2_Missense_Mutation_p.I721M|PTPRD_uc003zkl.2_Missense_Mutation_p.I1133M|PTPRD_uc003zkm.2_Missense_Mutation_p.I1129M|PTPRD_uc003zkn.2_Missense_Mutation_p.I731M|PTPRD_uc003zko.2_Missense_Mutation_p.I728M	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1142	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GCACAATTATTATGTAGTAAC	0.393000										TSP Lung(15;0.13)			48	52					0	0	0.000147903	0	0
TOPORS	10210	broad.mit.edu	37	9	32541815	32541815	+	Missense_Mutation	SNP	C	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr9:32541815C>G	uc003zrb.2	-	3	2875	c.2708G>C	c.(2707-2709)CGT>CCT	p.R903P	TOPORS_uc003zrc.2_Missense_Mutation_p.R836P	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	903	Interaction with UBE2I.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		AACTGGGGAACGTGAAGCATT	0.323000													58	90					0	0	0.000147903	0	0
VCP	7415	broad.mit.edu	37	9	35061057	35061057	+	Silent	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr9:35061057A>G	uc003zvy.2	-	11	1703	c.1314T>C	c.(1312-1314)GAT>GAC	p.D438D	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_Silent_p.D107D|VCP_uc010mki.1_Silent_p.D393D	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	438					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TGACCTCGGCATCAATGGTCT	0.537000													111	108					0	0	0.000147903	0	0
TMEM2	23670	broad.mit.edu	37	9	74313090	74313090	+	Missense_Mutation	SNP	G	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr9:74313090G>T	uc011lsa.1	-	20	3948	c.3408C>A	c.(3406-3408)AGC>AGA	p.S1136R	TMEM2_uc011lrz.1_Missense_Mutation_p.S129R|TMEM2_uc010mos.2_Missense_Mutation_p.S1073R|TMEM2_uc011lsb.1_RNA|TMEM2_uc004aik.2_5'UTR	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	1136						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		CATGCCTGTGGCTTTTGGCTT	0.413000													39	73					2.00842e-17	9.86615e-16	8.96297e-05	1	0
FLJ46321	389763	broad.mit.edu	37	9	84609482	84609482	+	Missense_Mutation	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr9:84609482T>C	uc004amn.2	+	4	4144	c.4097T>C	c.(4096-4098)ATA>ACA	p.I1366T		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1366						integral to membrane					0						AAACCCAGCATATCATATGAA	0.433000													10	12					0	0	3.86212e-05	0	0
PAPPA	5069	broad.mit.edu	37	9	118949550	118949550	+	Missense_Mutation	SNP	G	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr9:118949550G>T	uc004bjn.2	+	2	914	c.533G>T	c.(532-534)CGA>CTA	p.R178L	PAPPA_uc011lxp.1_5'UTR|PAPPA_uc011lxq.1_5'UTR	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	178					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						AAGACAGACCGAGCCCGGCAA	0.532000													26	39					2.79863e-10	1.32024e-08	9.22233e-05	1	0
FAM123B	139285	broad.mit.edu	37	X	63411696	63411696	+	Missense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chrX:63411696G>A	uc004dvo.2	-	2	1744	c.1471C>T	c.(1471-1473)CGC>TGC	p.R491C		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	491					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CAATCCCTGCGGACAAGCCCC	0.522000													16	4					0	0	9.7654e-05	0	0
TAS1R3	83756	broad.mit.edu	37	1	1269265	1269265	+	Silent	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr1:1269265G>A	uc010nyk.1	+	6	1980	c.1980G>A	c.(1978-1980)GTG>GTA	p.V660V		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	660	Helical; Name=3; (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	AGATCTTCGTGGAGTCAGAAC	0.582000													8	20					0	0	0.000274275	0	0
EPHA8	2046	broad.mit.edu	37	1	22902942	22902942	+	Missense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr1:22902942G>A	uc001bfx.1	+	3	517	c.392G>A	c.(391-393)CGC>CAC	p.R131H	EPHA8_uc001bfw.2_Missense_Mutation_p.R131H	NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	131	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GAGTCGGACCGCGACCTGGGG	0.587000													21	26					0	0	0.000175454	0	0
KDM4A	9682	broad.mit.edu	37	1	44169937	44169937	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr1:44169937A>G	uc001cjx.2	+	22	3257	c.3091A>G	c.(3091-3093)ACA>GCA	p.T1031A	uc001cjy.2_Intron|ST3GAL3_uc009vwu.1_5'Flank|KDM4A_uc010oki.1_3'UTR	NM_014663	NP_055478	O75164	KDM4A_HUMAN	jumonji domain containing 2A	1031					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1						TGAGATTTTCACAGAGAAAGA	0.438000													4	165					0	0	0.00024832	0	0
SLC6A9	6536	broad.mit.edu	37	1	44467233	44467233	+	Silent	SNP	G	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr1:44467233G>C	uc001cll.2	-	9	1440	c.1248C>G	c.(1246-1248)TCC>TCG	p.S416S	SLC6A9_uc009vxe.2_Silent_p.S272S|SLC6A9_uc010okm.1_Silent_p.S343S|SLC6A9_uc001clm.2_Silent_p.S362S|SLC6A9_uc009vxd.2_RNA|SLC6A9_uc010okn.1_Silent_p.S347S|SLC6A9_uc001cln.2_Silent_p.S343S|SLC6A9_uc010oko.1_Silent_p.S232S|SLC6A9_uc010okp.1_RNA	NM_201649	NP_964012	P48067	SC6A9_HUMAN	solute carrier family 6 member 9 isoform 2	416	Helical; Name=7; (Potential).					integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity				0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	AGCCGAGGATGGAGAAGATGA	0.597000													4	99					0	0	0.00024832	0	0
FGGY	55277	broad.mit.edu	37	1	59812021	59812021	+	Missense_Mutation	SNP	G	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr1:59812021G>C	uc001czi.3	+	4	628	c.416G>C	c.(415-417)GGG>GCG	p.G139A	FGGY_uc001czg.2_Missense_Mutation_p.G27A|FGGY_uc001czh.2_RNA|FGGY_uc009wac.2_Missense_Mutation_p.G139A|FGGY_uc001czj.3_Missense_Mutation_p.G139A|FGGY_uc001czk.3_Missense_Mutation_p.G27A|FGGY_uc001czl.3_Intron	NM_018291	NP_060761	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	139					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(1)	1	all_cancers(7;7.36e-05)					TACGTCGGGGGGGTGATGTCT	0.502000													3	41					0	0	0.00024832	0	0
NBPF14	25832	broad.mit.edu	37	1	148009508	148009509	+	Missense_Mutation	DNP	CC	AA	AA	rs143363070	by1000genomes	TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr1:148009508_148009509CC>AA	uc001eqq.2	-	16	1815_1816	c.1798_1799GG>TT	c.(1798-1800)GGG>TTG	p.G600L	LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqf.2_Intron|LOC200030_uc001eqg.2_Intron|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Missense_Mutation_p.G173L|NBPF14_uc001eqx.2_Intron|NBPF14_uc010pad.1_Intron|NBPF14_uc001eqs.1_Intron	NM_015383	NP_056198	Q5TI25	NBPFE_HUMAN	hypothetical protein LOC25832	600	NBPF 7.					cytoplasm				ovary(1)	1	all_hematologic(923;0.032)					CAACAGCTCCCCGCTGAGCCTG	0.465000													11	283					0	0	6.4e-05	0	0
PSMB4	5692	broad.mit.edu	37	1	151372078	151372078	+	Silent	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr1:151372078G>A	uc001eyc.1	+	1	38	c.15G>A	c.(13-15)TTG>TTA	p.L5L	PSMB4_uc010pda.1_Silent_p.L5L|PSMB4_uc001eyb.1_Silent_p.L5L	NM_002796	NP_002787	P28070	PSB4_HUMAN	proteasome beta 4 subunit	5					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			ovary(2)	2	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			AAGCGTTTTTGGGGTCGCGGT	0.542000													41	59					0	0	0.000147903	0	0
C1orf66	51093	broad.mit.edu	37	1	156705540	156705540	+	Missense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr1:156705540G>A	uc001fpu.2	+	7	1779	c.1145G>A	c.(1144-1146)CGA>CAA	p.R382Q	C1orf66_uc001fpv.2_Silent_p.A220A	NM_015997	NP_057081	Q96FB5	RRNAD_HUMAN	hypothetical protein LOC51093 isoform 1	382						integral to membrane	rRNA (adenine-N6,N6-)-dimethyltransferase activity				0	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGGCTACAGCGAGTGGGGCTA	0.547000													28	31					0	0	7.24521e-05	0	0
INSRR	3645	broad.mit.edu	37	1	156823725	156823725	+	Silent	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr1:156823725G>A	uc010pht.1	-	2	710	c.456C>T	c.(454-456)ACC>ACT	p.T152T	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron|INSRR_uc009wsj.1_Silent_p.T152T	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	152					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCCAGTCAATGGTGGAGAGGT	0.642000													5	10					0	0	1.23904e-05	0	0
PLEKHA6	22874	broad.mit.edu	37	1	204226699	204226699	+	Missense_Mutation	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr1:204226699C>T	uc001hau.2	-	9	1623	c.1306G>A	c.(1306-1308)GAG>AAG	p.E436K	PLEKHA6_uc009xaw.1_Missense_Mutation_p.E60K|PLEKHA6_uc009xax.1_Missense_Mutation_p.E60K|PLEKHA6_uc009xay.1_Missense_Mutation_p.E60K|PLEKHA6_uc009xaz.1_Missense_Mutation_p.E60K|PLEKHA6_uc009xba.1_Missense_Mutation_p.E60K|PLEKHA6_uc009xbb.1_Missense_Mutation_p.E60K|PLEKHA6_uc009xbc.1_Missense_Mutation_p.E60K	NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	436										ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			GCATCCAGCTCATCATAATAG	0.687000													9	6					0	0	6.40141e-05	0	0
KCNH1	3756	broad.mit.edu	37	1	211192165	211192165	+	Missense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr1:211192165G>A	uc001hib.2	-	6	1162	c.992C>T	c.(991-993)GCT>GTT	p.A331V	KCNH1_uc001hic.2_Intron	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	331	Extracellular (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		AATCTGATCAGCAAAACCAAT	0.448000													47	90					0	0	0.000147903	0	0
SPATA17	128153	broad.mit.edu	37	1	217975148	217975148	+	Nonsense_Mutation	SNP	G	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr1:217975148G>T	uc001hlh.1	+	9	987	c.961G>T	c.(961-963)GAA>TAA	p.E321*	SPATA17_uc001hli.2_Nonsense_Mutation_p.E321*	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	321						cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		TTCTTACAAAGAACAATTCCG	0.294000													24	29					4.4004e-07	2.06295e-05	5.49717e-05	1	0
OBSCN	84033	broad.mit.edu	37	1	228494234	228494234	+	Missense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr1:228494234G>A	uc009xez.1	+	44	11865	c.11821G>A	c.(11821-11823)GGC>AGC	p.G3941S	OBSCN_uc001hsn.2_Missense_Mutation_p.G3941S	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3941	Ig-like 40.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				ACGGCTTCAGGGCTGCACCGC	0.632000													25	21					0	0	0.000147802	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72503320	72503320	+	Missense_Mutation	SNP	G	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr10:72503320G>T	uc001jrh.2	+	13	1941	c.1941G>T	c.(1939-1941)GAG>GAT	p.E647D	ADAMTS14_uc001jrg.2_Missense_Mutation_p.E650D|ADAMTS14_uc001jri.1_Missense_Mutation_p.E170D	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	647	Cys-rich.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						AGAAGTGTGAGCTGATCTGCC	0.597000													15	25					6.81908e-15	3.35669e-13	0.000219431	1	0
CPEB3	22849	broad.mit.edu	37	10	93812079	93812079	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr10:93812079A>G	uc001khw.1	-	10	2160	c.1987T>C	c.(1987-1989)TGT>CGT	p.C663R	CPEB3_uc001khu.1_Missense_Mutation_p.C672R|CPEB3_uc001khv.1_Missense_Mutation_p.C649R|CPEB3_uc010qnn.1_Missense_Mutation_p.C649R	NM_014912	NP_055727	Q8NE35	CPEB3_HUMAN	cytoplasmic polyadenylation element binding	663							nucleotide binding|RNA binding				0		Colorectal(252;0.0869)				CAGTATTCACAGTAATACTGC	0.592000													16	20					0	0	0.000308642	0	0
KNDC1	85442	broad.mit.edu	37	10	135012252	135012252	+	Missense_Mutation	SNP	G	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr10:135012252G>C	uc001llz.1	+	14	2241	c.2240G>C	c.(2239-2241)GGG>GCG	p.G747A	KNDC1_uc001lma.1_Missense_Mutation_p.G682A|KNDC1_uc001lmb.1_Missense_Mutation_p.G159A	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	747	Pro-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GAGCCTCTTGGGGCGTCAGTG	0.726000													3	2					0	0	6.4e-05	0	0
HARBI1	283254	broad.mit.edu	37	11	46637368	46637368	+	Silent	SNP	C	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr11:46637368C>A	uc001ncy.2	-	2	668	c.420G>T	c.(418-420)GGG>GGT	p.G140G	KIAA0652_uc009yld.2_5'Flank|KIAA0652_uc001nda.2_5'Flank|KIAA0652_uc001ndb.2_5'Flank|KIAA0652_uc001ncz.2_5'Flank|KIAA0652_uc001ndc.2_5'Flank|KIAA0652_uc010rgv.1_5'Flank	NM_173811	NP_776172	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	140						cytoplasm|nucleus	metal ion binding|nuclease activity				0						CCCCTGGCATCCCTGCCAACC	0.512000													63	117					7.1157e-29	3.71968e-27	0.000147903	1	0
SAPS3	55291	broad.mit.edu	37	11	68377390	68377390	+	Silent	SNP	T	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr11:68377390T>A	uc001onw.2	+	23	2736	c.2469T>A	c.(2467-2469)TCT>TCA	p.S823S	SAPS3_uc001onv.2_Silent_p.S829S|SAPS3_uc001ony.3_Silent_p.S794S|SAPS3_uc001onx.2_Silent_p.S817S|SAPS3_uc009ysh.2_Silent_p.S743S|SAPS3_uc001onu.2_Silent_p.S743S|SAPS3_uc010rqc.1_Silent_p.S591S|SAPS3_uc010rqd.1_Silent_p.S506S|SAPS3_uc001onz.2_Silent_p.S151S|SAPS3_uc001ooa.2_Silent_p.S279S	NM_001164161	NP_001157633	Q5H9R7	PP6R3_HUMAN	SAPS domain family, member 3 isoform 6	823					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)			GGAAACTGTCTACCTCTCAAG	0.577000													51	64					0	0	0.000147903	0	0
ANKK1	255239	broad.mit.edu	37	11	113270078	113270078	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr11:113270078A>G	uc001pny.2	+	8	1481	c.1387A>G	c.(1387-1389)ACC>GCC	p.T463A		NM_178510	NP_848605	Q8NFD2	ANKK1_HUMAN	ankyrin repeat and kinase domain containing 1	463	ANK 4.						ATP binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|ovary(1)|breast(1)	8		all_cancers(61;1.53e-11)|all_epithelial(67;3e-06)|Melanoma(852;4.04e-05)|all_hematologic(158;0.000315)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0461)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Prostate(24;0.194)		BRCA - Breast invasive adenocarcinoma(274;4.82e-06)|Epithelial(105;5.41e-05)|all cancers(92;0.000442)|OV - Ovarian serous cystadenocarcinoma(223;0.238)		TGAAGGGTGGACCCCTCTTCA	0.622000													3	6					0	0	6.4e-05	0	0
PEX5	5830	broad.mit.edu	37	12	7343122	7343122	+	Splice_Site	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr12:7343122T>C	uc009zfu.1	+	3	727	c.147_splice	c.e3+2	p.A49_splice	PEX5_uc001qsw.2_Splice_Site_p.A49_splice|PEX5_uc010sgc.1_Missense_Mutation_p.V50A|PEX5_uc001qsu.2_Splice_Site_p.A49_splice|PEX5_uc010sgd.1_Splice_Site_p.A70_splice|PEX5_uc001qsv.2_Splice_Site_p.A49_splice	NM_001131026	NP_001124498	P50542	PEX5_HUMAN	peroxisomal biogenesis factor 5 isoform d						protein import into peroxisome matrix, translocation|protein targeting to peroxisome|protein tetramerization|protein transport	cytosol|peroxisomal matrix|peroxisomal membrane	peroxisome matrix targeting signal-1 binding|protein C-terminus binding|protein N-terminus binding			ovary(1)	1						TCTGAGGCAGTGAGTGTTCTT	0.632000													10	10					0	0	3.86212e-05	0	0
GSG1	83445	broad.mit.edu	37	12	13243503	13243503	+	Missense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr12:13243503G>A	uc001rbn.2	-	2	471	c.298C>T	c.(298-300)CGG>TGG	p.R100W	GSG1_uc001rbj.2_Missense_Mutation_p.R87W|GSG1_uc001rbk.2_Missense_Mutation_p.R87W|GSG1_uc001rbl.2_Missense_Mutation_p.R87W|GSG1_uc001rbm.2_Missense_Mutation_p.R87W|GSG1_uc001rbo.2_Missense_Mutation_p.R100W|GSG1_uc001rbp.2_Missense_Mutation_p.R100W|GSG1_uc001rbq.1_Missense_Mutation_p.R100W	NM_001080555	NP_001074024	Q2KHT4	GSG1_HUMAN	germ cell associated 1 isoform 4	87						endoplasmic reticulum membrane|integral to membrane					0		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		AAGGAGAACCGGTCATCCCCA	0.542000													6	117					0	0	0.000274275	0	0
IPO8	10526	broad.mit.edu	37	12	30790088	30790088	+	Silent	SNP	C	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr12:30790088C>G	uc001rjd.2	-	22	2693	c.2523G>C	c.(2521-2523)CTG>CTC	p.L841L	IPO8_uc001rje.1_Silent_p.L330L|IPO8_uc010sjt.1_Silent_p.L636L	NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	841					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					AAAGGATACTCAGTCCTATTA	0.393000													67	41					0	0	0.000147903	0	0
FAM60A	58516	broad.mit.edu	37	12	31435663	31435663	+	Missense_Mutation	SNP	A	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr12:31435663A>C	uc010sjz.1	-	6	888	c.649T>G	c.(649-651)TCC>GCC	p.S217A	FAM60A_uc001rkd.2_Missense_Mutation_p.S217A|FAM60A_uc010ska.1_Missense_Mutation_p.S217A|FAM60A_uc001rke.2_Missense_Mutation_p.S217A|FAM60A_uc010skb.1_RNA|FAM60A_uc001rkc.2_Missense_Mutation_p.S242A	NM_021238	NP_067061	Q9NP50	FA60A_HUMAN	family with sequence similarity 60, member A	217											0	all_cancers(9;5.22e-13)|all_epithelial(9;4e-13)|all_lung(12;1.2e-11)|Lung NSC(12;2.17e-09)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0207)|Lung SC(12;0.0592)|Esophageal squamous(101;0.162)					TCCTGAGTGGAGATGGGCAGA	0.453000													44	32					0	0	0.000147903	0	0
KRT83	3889	broad.mit.edu	37	12	52708468	52708468	+	Missense_Mutation	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr12:52708468C>T	uc001saf.2	-	9	1492	c.1429G>A	c.(1429-1431)GGC>AGC	p.G477S		NM_002282	NP_002273	P78385	KRT83_HUMAN	keratin 83	477	Tail.				epidermis development	keratin filament	structural molecule activity			skin(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TTCAGCTGGCCACAGGGCTTG	0.667000													5	7					0	0	1.23904e-05	0	0
HSP90B1	7184	broad.mit.edu	37	12	104336447	104336447	+	Missense_Mutation	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr12:104336447T>C	uc001tkb.1	+	12	1622	c.1517T>C	c.(1516-1518)CTT>CCT	p.L506P	HSP90B1_uc010swg.1_Missense_Mutation_p.L171P|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	506					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	CGAACACGTCTTGCTAAACTT	0.373000													79	51					0	0	0.000147903	0	0
MYO1H	283446	broad.mit.edu	37	12	109834250	109834250	+	Missense_Mutation	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr12:109834250C>T	uc010sxn.1	+	3	304	c.304C>T	c.(304-306)CTC>TTC	p.L102F		NM_001101421	NP_001094891	Q8N1T3	MYO1H_HUMAN	myosin 1H	Error:Variant_position_missing_in_B4DNW6_after_alignment						myosin complex	motor activity				0						CCATTTCATCCTCATTTCTGG	0.458000													39	33					0	0	0.000374591	0	0
NCOR2	9612	broad.mit.edu	37	12	124848291	124848291	+	Silent	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr12:124848291A>G	uc010tba.1	-	21	2979	c.2862T>C	c.(2860-2862)AAT>AAC	p.N954N	NCOR2_uc010tay.1_Silent_p.N954N|NCOR2_uc010taz.1_Silent_p.N937N|NCOR2_uc010tbb.1_Silent_p.N954N|NCOR2_uc010tbc.1_Silent_p.N936N|NCOR2_uc001ugj.1_Silent_p.N954N	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	954					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GGGGTGAGGCATTGGCCCGGG	0.697000													66	58					0	0	0.000147903	0	0
EP400	57634	broad.mit.edu	37	12	132522561	132522562	+	Missense_Mutation	DNP	GC	AT	AT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr12:132522561_132522562GC>AT	uc001ujn.2	+	31	6162_6163	c.6127_6128GC>AT	c.(6127-6129)GCT>ATT	p.A2043I	EP400_uc001ujl.2_Missense_Mutation_p.A2042I|EP400_uc001ujm.2_Missense_Mutation_p.A1962I	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2079					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CCCGGTCAAAGCTGAGGAGTTT	0.465000													53	148					0	0	6.4e-05	0	0
KBTBD6	89890	broad.mit.edu	37	13	41704906	41704906	+	Missense_Mutation	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr13:41704906T>C	uc001uxu.1	-	1	2031	c.1742A>G	c.(1741-1743)AAC>AGC	p.N581S	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Missense_Mutation_p.N515S|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	581	Kelch 5.						protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		AGTCACCCGGTTCTTTTTCCA	0.408000													119	78					0	0	0.000147903	0	0
LRCH1	23143	broad.mit.edu	37	13	47315858	47315859	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr13:47315858_47315859GG>TT	uc001vbj.2	+	19	2298_2299	c.2062_2063GG>TT	c.(2062-2064)GGG>TTG	p.G688L	LRCH1_uc001vbk.2_Missense_Mutation_p.G723L|LRCH1_uc001vbl.3_Intron	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	688	CH.									ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		GCTGGCACTCGGGGAGAAAGCC	0.515000													12	509					0	0	6.4e-05	0	0
NALCN	259232	broad.mit.edu	37	13	101944368	101944368	+	Missense_Mutation	SNP	G	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr13:101944368G>T	uc001vox.1	-	9	1209	c.1020C>A	c.(1018-1020)AGC>AGA	p.S340R	NALCN_uc001voy.2_Missense_Mutation_p.S55R|NALCN_uc001voz.2_Missense_Mutation_p.S340R|NALCN_uc001vpa.2_Missense_Mutation_p.S340R	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	340	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AGGTAGTGCTGCTTCTCGATC	0.438000													26	17					5.77227e-19	2.91426e-17	0.000227799	1	0
SIPA1L1	26037	broad.mit.edu	37	14	72055716	72055716	+	Missense_Mutation	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr14:72055716T>C	uc001xms.2	+	2	1475	c.1127T>C	c.(1126-1128)CTG>CCG	p.L376P	SIPA1L1_uc001xmt.2_Missense_Mutation_p.L376P|SIPA1L1_uc001xmu.2_Missense_Mutation_p.L376P|SIPA1L1_uc001xmv.2_Missense_Mutation_p.L376P	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	376					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		TCTGGACCTCTGTCTCATTCA	0.498000													20	38					0	0	0.000295444	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72055734	72055734	+	Missense_Mutation	SNP	T	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr14:72055734T>A	uc001xms.2	+	2	1493	c.1145T>A	c.(1144-1146)TTT>TAT	p.F382Y	SIPA1L1_uc001xmt.2_Missense_Mutation_p.F382Y|SIPA1L1_uc001xmu.2_Missense_Mutation_p.F382Y|SIPA1L1_uc001xmv.2_Missense_Mutation_p.F382Y	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	382					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		TCAGCCAGTTTTAGCTCCCCA	0.507000													17	34					0	0	5.01169e-05	0	0
THBS1	7057	broad.mit.edu	37	15	39885267	39885267	+	Missense_Mutation	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr15:39885267T>C	uc001zkh.2	+	18	3013	c.2834T>C	c.(2833-2835)ATC>ACC	p.I945T	THBS1_uc010bbi.2_Missense_Mutation_p.I417T	NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	945	TSP type-3 8.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	ATCGATGACATCTGTCCTGAG	0.478000													25	30					0	0	0.000184323	0	0
EPB42	2038	broad.mit.edu	37	15	43508525	43508525	+	Missense_Mutation	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr15:43508525C>T	uc001zra.3	-	2	437	c.137G>A	c.(136-138)CGC>CAC	p.R46H	EPB42_uc010bde.2_5'UTR|EPB42_uc001zrb.3_Missense_Mutation_p.R76H|EPB42_uc010udm.1_Missense_Mutation_p.R46H	NM_001114134	NP_001107606	P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2 isoform 2	46					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			ovary(2)	2		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		GACTGGAGCGCGGAAGTACAG	0.597000													26	34					0	0	0.000184323	0	0
Unknown	0	broad.mit.edu	37	15	76074693	76074693	+	Missense_Mutation	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr15:76074693C>T	uc010umm.1	+	9	765	c.688C>T	c.(688-690)CGG>TGG	p.R230W	uc002bba.1_5'Flank					SubName: Full=cDNA FLJ59077, highly similar to Golgin subfamily A member 6;																		AGAGAGGGCCCGGTGGCAGGA	0.403000													35	32					0	0	0.000106405	0	0
HMG20A	10363	broad.mit.edu	37	15	77756662	77756662	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr15:77756662A>G	uc002bcr.2	+	4	371	c.170A>G	c.(169-171)CAA>CGA	p.Q57R	HMG20A_uc002bcq.1_Missense_Mutation_p.Q57R|HMG20A_uc002bcs.2_Missense_Mutation_p.Q57R	NM_018200	NP_060670	Q9NP66	HM20A_HUMAN	high-mobility group 20A	57					chromatin modification	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						GATCTCTCTCAAGGTCAGTTG	0.448000													32	43					0	0	7.24521e-05	0	0
TSC2	7249	broad.mit.edu	37	16	2130345	2130345	+	Missense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr16:2130345G>A	uc002con.2	+	30	3683	c.3577G>A	c.(3577-3579)GGC>AGC	p.G1193S	TSC2_uc010bsd.2_Missense_Mutation_p.G1193S|TSC2_uc002coo.2_Missense_Mutation_p.G1149S|TSC2_uc010uvv.1_Missense_Mutation_p.G1113S|TSC2_uc010uvw.1_Missense_Mutation_p.G1101S|TSC2_uc002cop.2_Missense_Mutation_p.G949S|TSC2_uc002coq.2_5'Flank|TSC2_uc002cor.2_5'Flank	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	1193					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				GCTGACCCAGGGCTGGGCGGA	0.662000			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				22	60					0	0	0.000375601	0	0
PDXDC1	23042	broad.mit.edu	37	16	15127233	15127234	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr16:15127233_15127234CG>AT	uc002dda.3	+	19	2013_2014	c.1789_1790CG>AT	c.(1789-1791)CGG>ATG	p.R597M	PDXDC1_uc010uzl.1_Missense_Mutation_p.R582M|PDXDC1_uc010uzm.1_Missense_Mutation_p.R506M|PDXDC1_uc002ddb.3_Missense_Mutation_p.R570M|PDXDC1_uc010uzn.1_Missense_Mutation_p.R569M|PDXDC1_uc002ddc.2_Intron	NM_015027	NP_055842	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain	597					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	GGCCACAGCCCGGGAGATAGAG	0.564000													5	150					0	0	6.4e-05	0	0
LOC81691	81691	broad.mit.edu	37	16	20851091	20851091	+	Silent	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr16:20851091C>T	uc002dhv.2	+	14	1661	c.1398C>T	c.(1396-1398)GCC>GCT	p.A466A	ERI2_uc002dht.3_Intron|LOC81691_uc002dhx.2_Silent_p.A466A|LOC81691_uc002dhw.2_Silent_p.A209A|LOC81691_uc002dhy.3_Silent_p.A466A	NM_030941	NP_112203	Q96IC2	REXON_HUMAN	exonuclease NEF-sp isoform 1	466						nucleolus	exonuclease activity|nucleotide binding|RNA binding			ovary(1)|kidney(1)	2						TTGAGCAGGCCAGAGTGGAAA	0.448000													242	149					0	0	0.000147903	0	0
HYDIN	54768	broad.mit.edu	37	16	70843785	70843786	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr16:70843785_70843786CG>AT	uc002ezr.2	-	85	14908_14909	c.14780_14781CG>AT	c.(14779-14781)CCG>CAT	p.P4927H	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4928										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CAGGCTTTTCCGGAAGTGCTGG	0.485000													15	560					0	0	6.4e-05	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2908679	2908680	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr17:2908679_2908680GG>TT	uc010ckd.2	+	15	1307_1308	c.1217_1218GG>TT	c.(1216-1218)CGG>CTT	p.R406L	RAP1GAP2_uc010cke.2_Missense_Mutation_p.R391L	NM_015085	NP_055900	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2 isoform 1	406	Rap-GAP.				regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			ovary(1)	1						GTCACTGCGCGGGAAGATGTGC	0.594000													7	221					0	0	6.4e-05	0	0
DULLARD	23399	broad.mit.edu	37	17	7149598	7149598	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr17:7149598A>G	uc002gfd.2	-	5	832	c.452T>C	c.(451-453)ATT>ACT	p.I151T	DULLARD_uc002gfe.2_Missense_Mutation_p.I151T|DULLARD_uc002gff.2_Missense_Mutation_p.I151T|DULLARD_uc002gfc.2_RNA	NM_001143775	NP_001137247	O95476	CNEP1_HUMAN	dullard homolog	151	FCP1 homology.				nuclear envelope organization|protein dephosphorylation	endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein serine/threonine phosphatase activity				0						CCTCTTAAGAATGCTTCTGCT	0.498000													33	89					0	0	0.000132358	0	0
DNAH9	1770	broad.mit.edu	37	17	11687648	11687649	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr17:11687648_11687649CG>AT	uc002gne.2	+	41	7921_7922	c.7853_7854CG>AT	c.(7852-7854)CCG>CAT	p.P2618H	DNAH9_uc010coo.2_Missense_Mutation_p.P1912H	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2618	AAA 3 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CTCTCCTTCCCGGGGGCAGATG	0.530000													8	344					0	0	6.4e-05	0	0
NCOR1	9611	broad.mit.edu	37	17	16089949	16089949	+	Nonsense_Mutation	SNP	G	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr17:16089949G>C	uc002gpo.2	-	3	401	c.161C>G	c.(160-162)TCA>TGA	p.S54*	NCOR1_uc002gpn.2_Nonsense_Mutation_p.S54*|NCOR1_uc002gpp.1_Intron|NCOR1_uc002gpr.2_Intron|NCOR1_uc002gps.1_Nonsense_Mutation_p.S54*|NCOR1_uc010coz.1_Translation_Start_Site|NCOR1_uc010cpb.1_Nonsense_Mutation_p.S54*|NCOR1_uc010cpa.1_Nonsense_Mutation_p.S54*|NCOR1_uc002gpu.2_Nonsense_Mutation_p.S54*	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	54	Interaction with ZBTB33 and HEXIM1.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CAAAAGCTGTGATGCCTGACT	0.403000													28	57					0	0	0.000117367	0	0
SRCIN1	80725	broad.mit.edu	37	17	36708962	36708962	+	Missense_Mutation	SNP	C	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr17:36708962C>G	uc002hqd.2	-	12	2556	c.2331G>C	c.(2329-2331)AAG>AAC	p.K777N	SRCIN1_uc002hqf.1_Missense_Mutation_p.K649N|SRCIN1_uc002hqe.2_Missense_Mutation_p.K631N|SRCIN1_uc002hqg.2_Missense_Mutation_p.K83N	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	649	Potential.				exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0						CAGACCCACCCTTGAGCTCTG	0.632000													26	48					0	0	0.000184323	0	0
CASC3	22794	broad.mit.edu	37	17	38319005	38319005	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr17:38319005G>A	uc010cwt.1	+	6	931	c.636G>A	c.(634-636)TGG>TGA	p.W212*	CASC3_uc010cws.1_Nonsense_Mutation_p.W212*|CASC3_uc002hue.2_Nonsense_Mutation_p.W212*	NM_007359	NP_031385	O15234	CASC3_HUMAN	metastatic lymph node 51	212	Necessary for RNA-binding, interaction with MAGOH and localization in nucleus speckles.|Sufficient to form the EJC.				mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			ovary(1)	1						GAAAGCTATGGAAGGATGAGG	0.493000													12	39					0	0	6.40141e-05	0	0
MPO	4353	broad.mit.edu	37	17	56348163	56348163	+	Missense_Mutation	SNP	A	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr17:56348163A>T	uc002ivu.1	-	12	2269	c.2092T>A	c.(2092-2094)TCA>ACA	p.S698T		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	698					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	CGGGGCAATGAGATCTGGGCC	0.547000													46	26					0	0	0.000147903	0	0
INTS2	57508	broad.mit.edu	37	17	59981846	59981846	+	Missense_Mutation	SNP	G	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr17:59981846G>T	uc002izn.2	-	9	1382	c.1306C>A	c.(1306-1308)CTA>ATA	p.L436I	INTS2_uc002izm.2_Missense_Mutation_p.L428I	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	436	Helical; (Potential).				snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						AAGGCCAGTAGCATACAAAAG	0.403000													16	9					4.7546e-09	2.26496e-07	0.000422831	1	0
PIP5K1C	23396	broad.mit.edu	37	19	3648675	3648675	+	Missense_Mutation	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr19:3648675C>T	uc002lyj.1	-	9	1216	c.1159G>A	c.(1159-1161)GGG>AGG	p.G387R	PIP5K1C_uc010xhq.1_Missense_Mutation_p.G387R|PIP5K1C_uc010xhr.1_Missense_Mutation_p.G387R	NM_012398	NP_036530	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	387	PIPK.				axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			stomach(2)|skin(2)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		AGCCGCTCCCCGCGGCCGTTC	0.692000													20	17					0	0	0.000295444	0	0
APBA3	9546	broad.mit.edu	37	19	3760228	3760228	+	Missense_Mutation	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr19:3760228C>T	uc002lyp.1	-	2	212	c.35G>A	c.(34-36)GGG>GAG	p.G12E	MRPL54_uc002lyq.3_5'Flank	NM_004886	NP_004877	O96018	APBA3_HUMAN	amyloid beta (A4) precursor protein-binding,	12					intracellular signal transduction|protein transport	intracellular|membrane	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCTGGAGGCCCCGAAGGGGA	0.622000													8	11					0	0	0.000157383	0	0
PSMD8	5714	broad.mit.edu	37	19	38874011	38874011	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr19:38874011A>G	uc002oii.3	+	7	1086	c.1034A>G	c.(1033-1035)CAG>CGG	p.Q345R		NM_002812	NP_002803	P48556	PSMD8_HUMAN	proteasome 26S non-ATPase subunit 8	345					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome regulatory particle	protein binding			central_nervous_system(1)	1	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TATGCCCGGCAGCTGGAGATG	0.557000													7	15					0	0	0.000157383	0	0
ZNF180	7733	broad.mit.edu	37	19	44981073	44981073	+	Missense_Mutation	SNP	G	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr19:44981073G>C	uc002ozf.3	-	5	1907	c.1625C>G	c.(1624-1626)ACT>AGT	p.T542S	ZNF180_uc002ozh.3_Missense_Mutation_p.T199S|ZNF180_uc002ozi.3_Missense_Mutation_p.T515S|ZNF180_uc002ozg.3_Missense_Mutation_p.T541S|ZNF180_uc010ejm.2_Missense_Mutation_p.T517S	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	542	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				TCCAGTGTGAGTTCTTTGATG	0.423000													29	48					0	0	0.000184323	0	0
RSPH6A	81492	broad.mit.edu	37	19	46317979	46317979	+	Silent	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr19:46317979G>A	uc002pdm.2	-	1	599	c.456C>T	c.(454-456)TAC>TAT	p.Y152Y		NM_030785	NP_110412	Q9H0K4	RSH6A_HUMAN	radial spokehead-like 1	152						intracellular				ovary(1)|central_nervous_system(1)	2						GGTCTGTCTGGTAGAGGTTGA	0.602000													12	33					0	0	6.40141e-05	0	0
LILRA3	11026	broad.mit.edu	37	19	54803120	54803120	+	Missense_Mutation	SNP	G	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr19:54803120G>T	uc002qfd.2	-	4	622	c.557C>A	c.(556-558)CCC>CAC	p.P186H	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Intron	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	186	Ig-like C2-type 2.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGGGCTCACGGGGCCCACGGA	0.587000													36	51					4.62619e-21	2.35577e-19	0.000132358	1	0
ZNF324B	388569	broad.mit.edu	37	19	58966903	58966903	+	Missense_Mutation	SNP	T	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr19:58966903T>A	uc002qsv.1	+	4	699	c.592T>A	c.(592-594)TGT>AGT	p.C198S	ZNF324B_uc002qsu.1_Missense_Mutation_p.C188S|ZNF324B_uc010euq.1_Missense_Mutation_p.C198S	NM_207395	NP_997278	Q6AW86	Z324B_HUMAN	zinc finger protein 324B	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		GCAGAAGCCATGTGCACAGGA	0.672000													16	23					0	0	0.000422831	0	0
PAPOLG	64895	broad.mit.edu	37	2	61009021	61009021	+	Missense_Mutation	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr2:61009021T>C	uc002sai.2	+	11	1139	c.908T>C	c.(907-909)GTA>GCA	p.V303A	PAPOLG_uc002saj.2_5'UTR|PAPOLG_uc002sak.2_5'UTR|PAPOLG_uc010fch.2_5'UTR	NM_022894	NP_075045	Q9BWT3	PAPOG_HUMAN	poly(A) polymerase gamma	303					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(2;0.0797)		LUSC - Lung squamous cell carcinoma(5;1.19e-07)|Lung(5;2.86e-06)|Epithelial(17;0.0768)			ATTTCACAGGTAAATCCATCA	0.358000													3	116					0	0	0.00024832	0	0
TGFA	7039	broad.mit.edu	37	2	70742029	70742029	+	Missense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr2:70742029G>A	uc002sgs.3	-	2	262	c.56C>T	c.(55-57)GCG>GTG	p.A19V	TGFA_uc010fdq.2_Missense_Mutation_p.A25V|TGFA_uc010fdr.2_Missense_Mutation_p.A25V|TGFA_uc002sgt.3_Missense_Mutation_p.A19V|TGFA_uc002sgu.2_Missense_Mutation_p.A19V|TGFA_uc002sgv.2_Missense_Mutation_p.A19V|TGFA_uc002sgw.2_Missense_Mutation_p.A19V	NM_003236	NP_003227	P01135	TGFA_HUMAN	transforming growth factor, alpha isoform 1	19					activation of MAPK activity|cell proliferation|positive regulation of cell division|positive regulation of epidermal growth factor receptor activity|positive regulation of epithelial cell proliferation|positive regulation of mitosis	cell surface|extracellular space|integral to membrane|plasma membrane	epidermal growth factor receptor binding|growth factor activity|MAP kinase kinase activity|signal transducer activity			prostate(1)	1						GGCCTGGCACGCAGCCAACAC	0.597000													21	22					0	0	0.000295444	0	0
DCTN1	1639	broad.mit.edu	37	2	74597431	74597431	+	Missense_Mutation	SNP	T	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr2:74597431T>A	uc002skx.2	-	12	1480	c.1169A>T	c.(1168-1170)AAG>ATG	p.K390M	DCTN1_uc002skv.2_Missense_Mutation_p.K256M|DCTN1_uc002sku.2_Missense_Mutation_p.K256M|DCTN1_uc002skw.1_Missense_Mutation_p.K366M|DCTN1_uc010ffd.2_Missense_Mutation_p.K370M|DCTN1_uc002sky.2_Missense_Mutation_p.K353M	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	390	Potential.				cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5						CTTCTGGAGCTTCACATGCTC	0.547000													19	41					0	0	0.000175454	0	0
MAP4K4	9448	broad.mit.edu	37	2	102493544	102493544	+	Silent	SNP	C	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr2:102493544C>A	uc002tbg.2	+	24	2941	c.2886C>A	c.(2884-2886)ATC>ATA	p.I962I	MAP4K4_uc002tbc.2_Silent_p.I1043I|MAP4K4_uc002tbd.2_Silent_p.I935I|MAP4K4_uc002tbe.2_Silent_p.I881I|MAP4K4_uc002tbf.2_Silent_p.I996I|MAP4K4_uc010yvy.1_Silent_p.I958I|MAP4K4_uc002tbh.2_Silent_p.I880I|MAP4K4_uc002tbi.2_Silent_p.I765I|MAP4K4_uc010yvz.1_Silent_p.I1002I|MAP4K4_uc002tbk.2_Silent_p.I417I|MAP4K4_uc002tbl.2_Silent_p.I148I	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	962	CNH.|Mediates interaction with RAP2A.				intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4						ATCCTCTTATCAACCGAAGAC	0.453000													49	31					9.58827e-17	4.75949e-15	0.000147903	1	0
UPP2	151531	broad.mit.edu	37	2	158971732	158971732	+	Silent	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr2:158971732A>G	uc002tzp.2	+	3	494	c.300A>G	c.(298-300)AGA>AGG	p.R100R	UPP2_uc002tzo.2_Silent_p.R157R	NM_173355	NP_775491	O95045	UPP2_HUMAN	uridine phosphorylase 2 isoform a	100					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity				0						GGACAGACAGATACTGTATGT	0.458000													33	74					0	0	7.24521e-05	0	0
TTN	7273	broad.mit.edu	37	2	179468605	179468605	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr2:179468605A>G	uc010zfg.1	-	231	47329	c.47105T>C	c.(47104-47106)ATA>ACA	p.I15702T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.I9397T|TTN_uc010zfi.1_Missense_Mutation_p.I9330T|TTN_uc010zfj.1_Missense_Mutation_p.I9205T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16629							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATACTTACATATGGGATCTCC	0.398000													25	50					0	0	5.49717e-05	0	0
RPL37A	6168	broad.mit.edu	37	2	217364692	217364692	+	Silent	SNP	T	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr2:217364692T>A	uc002vgf.2	+	3	231	c.153T>A	c.(151-153)GCT>GCA	p.A51A	RPL37A_uc002vgg.2_Silent_p.A51A	NM_000998	NP_000989	P61513	RL37A_HUMAN	ribosomal protein L37a	51	C4-type.				endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	metal ion binding|protein binding|structural constituent of ribosome			ovary(1)	1		Renal(323;0.0458)		Epithelial(149;3.51e-06)|all cancers(144;0.000249)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGAGACGAGCTGTGGGGATCT	0.443000													70	62					0	0	0.000147903	0	0
COL4A3	1285	broad.mit.edu	37	2	228118302	228118303	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr2:228118302_228118303CG>AT	uc002vom.1	+	13	875_876	c.713_714CG>AT	c.(712-714)CCG>CAT	p.P238H	COL4A3_uc002von.1_Missense_Mutation_p.P238H|COL4A3_uc002voo.1_Missense_Mutation_p.P238H|COL4A3_uc002vop.1_Missense_Mutation_p.P238H|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	238	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		ACAGGACCCCCGGGACCACCAG	0.436000													9	275					0	0	6.4e-05	0	0
SP110	3431	broad.mit.edu	37	2	231077477	231077477	+	Silent	SNP	T	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr2:231077477T>G	uc002vqh.3	-	4	822	c.582A>C	c.(580-582)TCA>TCC	p.S194S	SP110_uc002vqg.3_Silent_p.S194S|SP110_uc002vqi.3_Silent_p.S194S|SP110_uc010fxk.2_Silent_p.S194S	NM_004509	NP_004500	Q9HB58	SP110_HUMAN	SP110 nuclear body protein isoform a	194					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			ovary(2)|breast(2)	4		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		GTTTCTCACCTGAAGTGCTTC	0.532000													129	107					0	0	0.000147903	0	0
MMP24	10893	broad.mit.edu	37	20	33851638	33851638	+	Missense_Mutation	SNP	C	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr20:33851638C>A	uc002xbu.2	+	5	865	c.862C>A	c.(862-864)CTG>ATG	p.L288M	EDEM2_uc010zuv.1_Intron	NM_006690	NP_006681	Q9Y5R2	MMP24_HUMAN	matrix metalloproteinase 24 preproprotein	288	Extracellular (Potential).				proteolysis	integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GGGCCACGCGCTGGGACTGGA	0.627000													6	5					1.6384e-10	7.93281e-09	8.12818e-05	1	0
EPB41L1	2036	broad.mit.edu	37	20	34800245	34800245	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr20:34800245A>G	uc002xfb.2	+	16	2302	c.2131A>G	c.(2131-2133)ATT>GTT	p.I711V	EPB41L1_uc002xeu.2_Missense_Mutation_p.I637V|EPB41L1_uc010zvo.1_Missense_Mutation_p.I711V|EPB41L1_uc002xev.2_Missense_Mutation_p.I711V|EPB41L1_uc002xew.2_Missense_Mutation_p.I602V|EPB41L1_uc002xex.2_Missense_Mutation_p.I531V|EPB41L1_uc002xey.2_Missense_Mutation_p.I489V|EPB41L1_uc002xez.2_Missense_Mutation_p.I637V|EPB41L1_uc010gfq.2_Missense_Mutation_p.I810V	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	711					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					TAGAAAGAAGATTGAGCCGGA	0.493000													26	52					0	0	0.000184323	0	0
NPEPL1	79716	broad.mit.edu	37	20	57276200	57276200	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr20:57276200A>G	uc010zzs.1	+	6	903	c.808A>G	c.(808-810)AGC>GGC	p.S270G	NPEPL1_uc010zzr.1_Missense_Mutation_p.S222G|NPEPL1_uc002xzn.2_RNA|NPEPL1_uc010gjo.1_Missense_Mutation_p.S242G|NPEPL1_uc002xzp.2_Missense_Mutation_p.S158G	NM_024663	NP_078939	Q8NDH3	PEPL1_HUMAN	aminopeptidase-like 1	270					proteolysis	cytoplasm	aminopeptidase activity|manganese ion binding|metalloexopeptidase activity				0	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;2.88e-09)|Colorectal(105;0.109)			TGGAGGCCTCAGCATCAAAGG	0.677000													4	3					0	0	0.00024832	0	0
NRIP1	8204	broad.mit.edu	37	21	16338944	16338944	+	Missense_Mutation	SNP	T	C	C	rs149069507	byFrequency	TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr21:16338944T>C	uc002yjx.2	-	4	2168	c.1570A>G	c.(1570-1572)AAT>GAT	p.N524D		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	524	Repression domain 2.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		CTCACATCATTGTGTACTCCC	0.403000													93	137					0	0	0.000147903	0	0
SETD4	54093	broad.mit.edu	37	21	37410517	37410517	+	Missense_Mutation	SNP	C	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr21:37410517C>G	uc002yuw.1	-	9	2492	c.1119G>C	c.(1117-1119)AAG>AAC	p.K373N	SETD4_uc002yux.1_Missense_Mutation_p.K349N|SETD4_uc002yuu.2_RNA|SETD4_uc002yuv.2_Missense_Mutation_p.K373N	NM_017438	NP_059134	Q9NVD3	SETD4_HUMAN	SET domain containing 4 isoform a	373				EILVKYLPSTDKQMDKKISILKDHGYIENLTFGWDGPSWRL LTALKLLCLEAEKFTCWKKVLLGEVISDTNEKTSLDIAQKI CYYFIEETNAVLQKVSHMKDEKEALINQLTLVESLWTEELK ILRASAETLHSLQTAFT -> GWNQLCS (in Ref. 5; AAH02898).						large_intestine(1)|ovary(1)	2						CCAAACTTGTCTTCTCATTCG	0.353000													54	60					0	0	0.000147903	0	0
CERK	64781	broad.mit.edu	37	22	47108141	47108141	+	Missense_Mutation	SNP	T	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr22:47108141T>G	uc003bia.2	-	4	536	c.429A>C	c.(427-429)AAA>AAC	p.K143N	CERK_uc010hae.2_5'UTR	NM_022766	NP_073603	Q8TCT0	CERK1_HUMAN	ceramide kinase	143	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|ceramide metabolic process	integral to membrane of membrane fraction|membrane|nucleus	ATP binding|ceramide kinase activity|diacylglycerol kinase activity|magnesium ion binding			skin(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TGCCTTGTCCTTTTCCTCCAA	0.388000													19	36					0	0	0.000295444	0	0
FGD5	152273	broad.mit.edu	37	3	14862878	14862879	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr3:14862878_14862879CC>AA	uc003bzc.2	+	1	2410_2411	c.2300_2301CC>AA	c.(2299-2301)CCC>CAA	p.P767Q	FGD5_uc011avk.1_Missense_Mutation_p.P767Q	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	767					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						ATCTCCTTCCCCAGCGCTGACA	0.594000													11	306					0	0	6.4e-05	0	0
NBEAL2	23218	broad.mit.edu	37	3	47049869	47049869	+	Missense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr3:47049869G>A	uc003cqp.2	+	51	7995	c.7816G>A	c.(7816-7818)GCA>ACA	p.A2606T	NBEAL2_uc010hjm.1_Missense_Mutation_p.A1983T|NBEAL2_uc010hjn.1_Missense_Mutation_p.A972T|NBEAL2_uc010hjo.1_Missense_Mutation_p.A166T	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	2606							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		TTTCCACCTGGCATTGGGGTC	0.597000													23	15					0	0	0.000295444	0	0
NICN1	84276	broad.mit.edu	37	3	49463424	49463424	+	Silent	SNP	C	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr3:49463424C>G	uc003cwz.1	-	3	400	c.315G>C	c.(313-315)CTG>CTC	p.L105L	NICN1_uc003cxa.2_RNA|NICN1_uc011bcr.1_Intron	NM_032316	NP_115692	Q9BSH3	NICN1_HUMAN	nicolin 1	105						microtubule|nucleus					0				BRCA - Breast invasive adenocarcinoma(193;4.52e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CCATGTCACACAGCATCTGAC	0.567000													11	23					0	0	6.40141e-05	0	0
SFMBT1	51460	broad.mit.edu	37	3	52988412	52988412	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr3:52988412A>G	uc003dgf.2	-	4	613	c.44T>C	c.(43-45)ATG>ACG	p.M15T	SFMBT1_uc003dgg.2_Missense_Mutation_p.M15T|SFMBT1_uc003dgh.2_Missense_Mutation_p.M15T	NM_001005159	NP_001005159	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	15					regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		TACCTCTTCCATACCAGAGCC	0.333000													105	74					0	0	0.000147903	0	0
LRIG1	26018	broad.mit.edu	37	3	66460690	66460690	+	Silent	SNP	C	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr3:66460690C>A	uc003dmx.2	-	7	812	c.798G>T	c.(796-798)CTG>CTT	p.L266L	LRIG1_uc010hnz.2_Silent_p.L6L|LRIG1_uc010hoa.2_Silent_p.L266L	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	266	Extracellular (Potential).|LRR 9.					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		TGTTGTACTCCAGGTGCCTGC	0.567000													8	236					0.000157383	0.00726299	0.000157383	1	0
ZBTB11	27107	broad.mit.edu	37	3	101390027	101390027	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr3:101390027A>G	uc003dve.3	-	3	955	c.725T>C	c.(724-726)CTT>CCT	p.L242P	ZBTB11_uc003dvf.2_3'UTR	NM_014415	NP_055230	O95625	ZBT11_HUMAN	zinc finger protein ZNF-U69274	242	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						CTCAATAAAAAGATCTCGAAA	0.363000													24	58					0	0	5.49717e-05	0	0
DRD3	1814	broad.mit.edu	37	3	113847594	113847595	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr3:113847594_113847595CG>AT	uc003ebd.2	-	8	1594_1595	c.1171_1172CG>AT	c.(1171-1173)CGG>ATG	p.R391M	DRD3_uc010hqn.1_Missense_Mutation_p.R391M|DRD3_uc003ebb.1_Missense_Mutation_p.R358M|DRD3_uc003ebc.1_Missense_Mutation_p.R391M	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	391	Cytoplasmic.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	GAAGGCTTTCCGGAACTCGATA	0.530000													9	477					0	0	6.4e-05	0	0
DIRC2	84925	broad.mit.edu	37	3	122598138	122598139	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr3:122598138_122598139CG>AT	uc003efw.3	+	9	1489_1490	c.1350_1351CG>AT	c.(1348-1353)CCCGGG>CCATGG	p.G451W	DIRC2_uc010hrl.2_RNA|DIRC2_uc010hrm.2_Missense_Mutation_p.G289W|uc003efx.1_RNA	NM_032839	NP_116228	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	451	Helical; (Potential).				transport	integral to membrane					0				GBM - Glioblastoma multiforme(114;0.0614)		GGTGCCTTCCCGGGTCGTGTTT	0.455000													16	580					0	0	6.4e-05	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133692538	133692538	+	Silent	SNP	G	C	C	rs150677069		TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr3:133692538G>C	uc003eqa.3	-	3	640	c.366C>G	c.(364-366)TCC>TCG	p.S122S	SLCO2A1_uc003eqb.3_Silent_p.S122S|SLCO2A1_uc011blv.1_Silent_p.S122S|SLCO2A1_uc010htw.1_5'UTR	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	122	Helical; Name=3; (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						GGTAGGGCTCGGAGAGGAAGT	0.582000													8	19					0	0	0.000274275	0	0
ATP13A3	79572	broad.mit.edu	37	3	194146121	194146121	+	Missense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr3:194146121G>A	uc003fty.3	-	29	3665	c.3263C>T	c.(3262-3264)GCA>GTA	p.A1088V	ATP13A3_uc003ftx.3_5'UTR	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	1088	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		AAAGGCAATTGCCACTATGAG	0.353000													47	40					0	0	0.000147903	0	0
ZBTB49	166793	broad.mit.edu	37	4	4322599	4322599	+	Silent	SNP	C	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr4:4322599C>A	uc003ghu.2	+	8	2029	c.1854C>A	c.(1852-1854)TCC>TCA	p.S618S	uc003ghw.2_5'Flank|ZBTB49_uc003ghv.2_Silent_p.S101S|ZBTB49_uc010icy.2_RNA|ZBTB49_uc010icz.2_Silent_p.S196S	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	zinc finger protein 509	618					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						ACTCTTTCTCCCAAGACACGT	0.547000													19	17					4.96729e-08	2.34734e-06	0.000132079	1	0
CCKAR	886	broad.mit.edu	37	4	26483517	26483517	+	Missense_Mutation	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr4:26483517C>T	uc003gse.1	-	5	1183	c.1030G>A	c.(1030-1032)GAG>AAG	p.E344K		NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor	344	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	AGGCGGCGCTCTGCGGAGGCG	0.592000													30	36					0	0	0.000184323	0	0
ANXA3	306	broad.mit.edu	37	4	79516549	79516549	+	Silent	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr4:79516549A>G	uc003hld.2	+	8	808	c.498A>G	c.(496-498)GAA>GAG	p.E166E	ANXA3_uc003hle.2_Silent_p.E127E|ANXA3_uc010ijk.2_Silent_p.E127E	NM_005139	NP_005130	P12429	ANXA3_HUMAN	annexin A3	166					defense response to bacterium|neutrophil degranulation|phagocytosis|positive regulation of angiogenesis|positive regulation of endothelial cell migration|positive regulation of sequence-specific DNA binding transcription factor activity	phagocytic vesicle membrane|plasma membrane|specific granule	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity				0						GAAGAGATGAAAGTCTGAAAG	0.443000													71	127					0	0	0.000147903	0	0
PLRG1	5356	broad.mit.edu	37	4	155470082	155470082	+	Silent	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr4:155470082T>C	uc003iny.2	-	2	78	c.15A>G	c.(13-15)GTA>GTG	p.V5V	PLRG1_uc003inz.2_Silent_p.V5V|PLRG1_uc011cil.1_5'UTR	NM_002669	NP_002660	O43660	PLRG1_HUMAN	pleiotropic regulator 1 (PRL1 homolog,	5						catalytic step 2 spliceosome|nuclear speck	protein binding|signal transducer activity|transcription corepressor activity				0	all_hematologic(180;0.215)	Renal(120;0.0854)				AATGTTTCTGTACCTCCTAAA	0.353000													11	18					0	0	3.86212e-05	0	0
SLC6A18	348932	broad.mit.edu	37	5	1225707	1225707	+	Missense_Mutation	SNP	G	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr5:1225707G>C	uc003jby.1	+	1	238	c.115G>C	c.(115-117)GGG>CGG	p.G39R		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	39	Helical; Name=1; (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CGTGGGACTGGGGAACATTTG	0.642000													4	19					0	0	0.000375601	0	0
TMEM167A	153339	broad.mit.edu	37	5	82357708	82357708	+	Missense_Mutation	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr5:82357708A>G	uc003khx.3	-	3	266	c.136T>C	c.(136-138)TGT>CGT	p.C46R		NM_174909	NP_777569	Q8TBQ9	KISHA_HUMAN	transmembrane protein 167A precursor	46	Extracellular (Potential).					Golgi membrane|integral to membrane					0						ATTCTGGCACACTTCCAAAAT	0.313000													25	23					0	0	0.000117367	0	0
PCSK1	5122	broad.mit.edu	37	5	95728748	95728748	+	Missense_Mutation	SNP	C	T	T	rs140941383		TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr5:95728748C>T	uc003kls.1	-	14	2425	c.2219G>A	c.(2218-2220)CGG>CAG	p.R740Q	PCSK1_uc010jbi.1_Missense_Mutation_p.R430Q	NM_000439	NP_000430	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	740	Amphipathic (Potential).				cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			ovary(2)	2		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTGAAGCAGCCGGTCGTCTCT	0.398000													91	112					0	0	0.000147903	0	0
CHD1	1105	broad.mit.edu	37	5	98236974	98236974	+	Missense_Mutation	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr5:98236974T>C	uc003knf.2	-	5	651	c.503A>G	c.(502-504)GAA>GGA	p.E168G		NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	168					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	CTCTCTCTCTTCTTCAGATTC	0.358000													60	64					0	0	0.000147903	0	0
GTF2H4	2968	broad.mit.edu	37	6	30877829	30877829	+	Silent	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr6:30877829C>T	uc003nsa.1	+	4	570	c.363C>T	c.(361-363)GCC>GCT	p.A121A	GTF2H4_uc010jsf.2_Silent_p.A121A|GTF2H4_uc011dmv.1_Silent_p.A65A|GTF2H4_uc003nsb.1_5'UTR|GTF2H4_uc011dmw.1_Silent_p.A127A	NM_001517	NP_001508	Q92759	TF2H4_HUMAN	general transcription factor IIH, polypeptide 4,	121					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3						TCCGCATTGCCCTTCTGGGTG	0.582000								NER					45	57					0	0	0.000147903	0	0
VARS2	57176	broad.mit.edu	37	6	30883015	30883015	+	Splice_Site	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr6:30883015G>A	uc003nsc.1	+	2	915	c.283_splice	c.e2+1	p.D95_splice	VARS2_uc003nsd.2_Splice_Site_p.D95_splice|VARS2_uc011dmx.1_Splice_Site_p.D95_splice|VARS2_uc011dmy.1_Splice_Site|VARS2_uc011dmz.1_Splice_Site_p.D125_splice|VARS2_uc011dna.1_Splice_Site_p.D95_splice|VARS2_uc011dnb.1_Splice_Site|VARS2_uc011dnc.1_Splice_Site	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial						valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4						GAAAAGAAAGGTAAGTAGAAT	0.453000													45	40					0	0	0.000437636	0	0
HLA-DQA2	3118	broad.mit.edu	37	6	32714066	32714066	+	Silent	SNP	C	T	T	rs143176293		TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr6:32714066C>T	uc003obx.2	+	4	721	c.663C>T	c.(661-663)TGC>TGT	p.C221C		NM_020056	NP_064440	P01906	DQA2_HUMAN	major histocompatibility complex, class II, DQ	221	Helical; (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTTTGGTCTGCGCCCTGGGGT	0.552000													62	70					0	0	0.000147903	0	0
SCUBE3	222663	broad.mit.edu	37	6	35199528	35199528	+	Missense_Mutation	SNP	G	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr6:35199528G>T	uc003okf.1	+	4	367	c.361G>T	c.(361-363)GGC>TGC	p.G121C	SCUBE3_uc003okg.1_Missense_Mutation_p.G121C|SCUBE3_uc003okh.1_5'UTR	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	121	EGF-like 3; calcium-binding (Potential).				protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						CGAGGGCAACGGCGGCTGTCA	0.582000													16	18					1.02788e-11	5.01794e-10	5.01169e-05	1	0
CDC5L	988	broad.mit.edu	37	6	44390515	44390515	+	Missense_Mutation	SNP	A	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr6:44390515A>T	uc003oxl.2	+	10	1632	c.1373A>T	c.(1372-1374)GAC>GTC	p.D458V		NM_001253	NP_001244	Q99459	CDC5L_HUMAN	CDC5-like	458	Interaction with PPP1R8.				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			lung(3)|ovary(1)|kidney(1)|skin(1)	6	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GGAATGGCAGACTATAGTGAT	0.383000													56	72					0	0	0.000147903	0	0
PLEKHG1	57480	broad.mit.edu	37	6	151151821	151151821	+	Missense_Mutation	SNP	C	T	T	rs138970683	by1000genomes	TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr6:151151821C>T	uc003qny.1	+	16	1886	c.1574C>T	c.(1573-1575)GCG>GTG	p.A525V	PLEKHG1_uc011eel.1_Missense_Mutation_p.A565V|PLEKHG1_uc011eem.1_Missense_Mutation_p.A584V|PLEKHG1_uc003qnz.2_Missense_Mutation_p.A525V	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	525					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		GTGCTTCGAGCGGGTGGAGCT	0.547000													11	22					0	0	3.86212e-05	0	0
SYNE1	23345	broad.mit.edu	37	6	152671451	152671451	+	Missense_Mutation	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr6:152671451T>C	uc010kiw.2	-	72	12355	c.11753A>G	c.(11752-11754)GAG>GGG	p.E3918G	SYNE1_uc003qot.3_Intron|SYNE1_uc003qou.3_Missense_Mutation_p.E3918G|SYNE1_uc010kja.1_Missense_Mutation_p.E623G	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3918	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GACTTTCGCCTCCAGACTGAA	0.473000										HNSCC(10;0.0054)			18	48					0	0	0.000175454	0	0
ARID1B	57492	broad.mit.edu	37	6	157527600	157527600	+	Silent	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr6:157527600G>A	uc003qqn.2	+	20	5423	c.5271G>A	c.(5269-5271)AAG>AAA	p.K1757K	ARID1B_uc003qqo.2_Silent_p.K1717K|ARID1B_uc003qqp.2_Silent_p.K1704K	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1762					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CAGACCCAAAGGAGAAGCCCA	0.517000													40	60					0	0	0.000228196	0	0
GPNMB	10457	broad.mit.edu	37	7	23296573	23296574	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr7:23296573_23296574GG>TT	uc003swc.2	+	4	591_592	c.430_431GG>TT	c.(430-432)GGG>TTG	p.G144L	GPNMB_uc003swa.2_Missense_Mutation_p.G144L|GPNMB_uc003swb.2_Missense_Mutation_p.G144L|GPNMB_uc011jyy.1_Intron|GPNMB_uc011jyz.1_Missense_Mutation_p.G45L	NM_001005340	NP_001005340	Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb isoform a	144	Extracellular (Potential).				negative regulation of cell proliferation	melanosome				ovary(3)|breast(2)	5			GBM - Glioblastoma multiforme(13;0.154)			GGACAGTGACGGGGAAAATGGC	0.480000													5	116					0	0	6.4e-05	0	0
TMEM120A	83862	broad.mit.edu	37	7	75617587	75617587	+	Silent	SNP	G	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr7:75617587G>T	uc003ued.2	-	7	650	c.546C>A	c.(544-546)CTC>CTA	p.L182L	TMEM120A_uc003uee.2_Silent_p.L86L|TMEM120A_uc003ueb.1_5'Flank|TMEM120A_uc003uec.2_Silent_p.L86L	NM_031925	NP_114131	Q9BXJ8	T120A_HUMAN	transmembrane protein 120A	182	Helical; (Potential).					integral to membrane					0						CGTTGTTGATGAGGATGCTCT	0.657000													36	53					6.03168e-27	3.09819e-25	0.000159656	1	0
PCLO	27445	broad.mit.edu	37	7	82545301	82545302	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr7:82545301_82545302GG>TT	uc003uhx.2	-	7	12289_12290	c.12000_12001CC>AA	c.(11998-12003)TCCCAT>TCAAAT	p.H4001N	PCLO_uc003uhv.2_Missense_Mutation_p.H4001N|PCLO_uc010lec.2_Missense_Mutation_p.H966N	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3932					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTACCAAGATGGGAAACAGCAA	0.391000													13	641					0	0	6.4e-05	0	0
ZAN	7455	broad.mit.edu	37	7	100349824	100349824	+	Missense_Mutation	SNP	C	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr7:100349824C>A	uc003uwj.2	+	14	2261	c.2096C>A	c.(2095-2097)TCC>TAC	p.S699Y	ZAN_uc003uwk.2_Missense_Mutation_p.S699Y|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	699	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCCACCATCTCCATGGAAGAG	0.512000													43	56					2.37825e-27	1.23231e-25	8.96297e-05	1	0
Unknown	0	broad.mit.edu	37	7	100551902	100551903	+	RNA	DNP	GG	TT	TT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr7:100551902_100551903GG>TT	uc003uxk.1	+	1		c.1153_1154GG>TT			uc003uxl.1_Missense_Mutation_p.R118I					Homo sapiens MUC3B mRNA for intestinal mucin, partial cds.																		TCTTTCACTAGGGGAAGTACGT	0.436000													15	887					0	0	6.4e-05	0	0
MUC17	140453	broad.mit.edu	37	7	100677147	100677148	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr7:100677147_100677148CG>AT	uc003uxp.1	+	3	2503_2504	c.2450_2451CG>AT	c.(2449-2451)CCG>CAT	p.P817H	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	817	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|11.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AGCATCACACCGGTGACCAGTC	0.490000													14	578					0	0	6.4e-05	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117431770	117431771	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr7:117431770_117431771GG>TT	uc003vjf.2	-	4	1571_1572	c.1479_1480CC>AA	c.(1477-1482)ACCCAA>ACAAAA	p.Q494K		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	494	Pro-rich.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GACAGTGCTTGGGTCACAGTAT	0.535000													11	545					0	0	6.4e-05	0	0
BRAF	673	broad.mit.edu	37	7	140434424	140434425	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr7:140434424_140434425CC>AA	uc003vwc.3	-	18	2334_2335	c.2273_2274GG>TT	c.(2272-2274)GGG>GTT	p.G758V		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	758					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	CACCATATCCCCCTGCCTGGAT	0.436000		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				15	680					0	0	6.4e-05	0	0
Unknown	0	broad.mit.edu	37	7	142498828	142498828	+	RNA	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr7:142498828C>T	uc011ksh.1	+	3		c.207C>T			uc011ksi.1_RNA|uc003vzw.1_RNA|uc010loj.1_RNA|uc003wad.2_RNA|uc003wag.1_3'UTR|uc003wbe.3_RNA|uc003wbf.3_RNA|uc003wbg.3_RNA|uc003wbh.3_Silent_p.G81G|uc003wbi.3_RNA|uc003wbj.3_RNA|uc003wbm.3_RNA|uc003wbn.3_RNA|uc010los.2_RNA					Homo sapiens mRNA for T-cell receptor beta chain, partial cds, clone:TCRVB.3.																		TGGCCACAGGCTTCTACCCCG	0.617000													39	116					0	0	0.000125731	0	0
EPHB6	2051	broad.mit.edu	37	7	142566068	142566068	+	Missense_Mutation	SNP	G	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr7:142566068G>C	uc011kst.1	+	14	2775	c.1988G>C	c.(1987-1989)CGG>CCG	p.R663P	EPHB6_uc011ksu.1_Missense_Mutation_p.R663P|EPHB6_uc003wbs.2_Missense_Mutation_p.R371P|EPHB6_uc003wbt.2_Missense_Mutation_p.R137P|EPHB6_uc003wbu.2_Missense_Mutation_p.R371P|EPHB6_uc003wbv.2_Missense_Mutation_p.R47P	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	663	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity	p.R648L(1)		lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					GAACTTGCCCGGGAAGTCGAT	0.577000													3	94					0	0	6.4e-05	0	0
ANGPT2	285	broad.mit.edu	37	8	6360731	6360731	+	Missense_Mutation	SNP	G	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr8:6360731G>T	uc003wqj.3	-	9	1711	c.1382C>A	c.(1381-1383)CCA>CAA	p.P461Q	MCPH1_uc003wqi.2_Intron|ANGPT2_uc003wqk.3_Missense_Mutation_p.P460Q|ANGPT2_uc010lri.2_Missense_Mutation_p.P409Q	NM_001147	NP_001138	O15123	ANGP2_HUMAN	angiopoietin 2 isoform a precursor	461	Fibrinogen C-terminal.				angiogenesis|blood coagulation|leukocyte migration|negative regulation of blood vessel endothelial cell migration|negative regulation of positive chemotaxis|Tie receptor signaling pathway	extracellular space	metal ion binding|receptor tyrosine kinase binding			upper_aerodigestive_tract(1)	1		Hepatocellular(245;0.0663)		Colorectal(4;0.0142)|READ - Rectum adenocarcinoma(4;0.19)|COAD - Colon adenocarcinoma(4;0.226)		CTGCCTCTGTGGATAGTACAT	0.463000													22	34					2.27731e-05	0.00105922	0.000229342	1	0
BIN3	55909	broad.mit.edu	37	8	22488017	22488017	+	Silent	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr8:22488017G>A	uc003xcl.2	-	5	332	c.235C>T	c.(235-237)CTG>TTG	p.L79L	BIN3_uc003xck.2_Silent_p.L31L|BIN3_uc010ltw.2_Silent_p.L25L	NM_018688	NP_061158	Q9NQY0	BIN3_HUMAN	bridging integrator 3	79	BAR.				actin filament organization|barrier septum formation|cell cycle|protein localization|unidimensional cell growth	cytoplasm|cytoskeleton	cytoskeletal adaptor activity				0		Prostate(55;0.0424)|Breast(100;0.102)|all_epithelial(46;0.143)		BRCA - Breast invasive adenocarcinoma(99;0.00664)|Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)		ACCATGTTCAGAAGGTCCTGG	0.532000													58	82					0	0	0.000147903	0	0
PROSC	11212	broad.mit.edu	37	8	37633451	37633452	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr8:37633451_37633452CG>AT	uc003xkh.2	+	7	690_691	c.613_614CG>AT	c.(613-615)CGG>ATG	p.R205M		NM_007198	NP_009129	O94903	PROSC_HUMAN	proline synthetase co-transcribed homolog	205							pyridoxal phosphate binding			central_nervous_system(1)	1		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)		L-Proline(DB00172)|Pyridoxal Phosphate(DB00114)	ATTGTCCCTCCGGGAGGAGCTG	0.510000													8	167					0	0	6.4e-05	0	0
FABP12	646486	broad.mit.edu	37	8	82441686	82441686	+	Missense_Mutation	SNP	C	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr8:82441686C>T	uc011lfp.1	-	2	233	c.233G>A	c.(232-234)GGC>GAC	p.G78D	FABP12_uc003ycg.3_RNA	NM_001105281	NP_001098751	A6NFH5	FBP12_HUMAN	fatty acid binding protein 12	78							lipid binding|transporter activity				0						TGTTTTGTGGCCACCTGGCGT	0.388000													70	108					0	0	0.000147903	0	0
RIPK2	8767	broad.mit.edu	37	8	90798839	90798839	+	Missense_Mutation	SNP	C	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr8:90798839C>G	uc003yee.2	+	9	1362	c.1048C>G	c.(1048-1050)CAG>GAG	p.Q350E	RIPK2_uc003yef.2_Missense_Mutation_p.Q213E	NM_003821	NP_003812	O43353	RIPK2_HUMAN	receptor-interacting serine-threonine kinase 2	350					activation of MAPK activity|anti-apoptosis|apoptosis|inflammatory response|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|CARD domain binding|LIM domain binding|protein homodimerization activity|protein serine/threonine kinase activity|signal transducer activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.0474)			TGGATCCTCTCAGCTCCATGA	0.323000													3	104					0	0	6.4e-05	0	0
PTPRD	5789	broad.mit.edu	37	9	8471073	8471073	+	Missense_Mutation	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr9:8471073T>C	uc003zkk.2	-	30	4137	c.3426A>G	c.(3424-3426)ATA>ATG	p.I1142M	PTPRD_uc003zkp.2_Missense_Mutation_p.I731M|PTPRD_uc003zkq.2_Missense_Mutation_p.I731M|PTPRD_uc003zkr.2_Missense_Mutation_p.I726M|PTPRD_uc003zks.2_Missense_Mutation_p.I721M|PTPRD_uc003zkl.2_Missense_Mutation_p.I1133M|PTPRD_uc003zkm.2_Missense_Mutation_p.I1129M|PTPRD_uc003zkn.2_Missense_Mutation_p.I731M|PTPRD_uc003zko.2_Missense_Mutation_p.I728M	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1142	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GCACAATTATTATGTAGTAAC	0.393000										TSP Lung(15;0.13)			48	52					0	0	0.000147903	0	0
TOPORS	10210	broad.mit.edu	37	9	32541815	32541815	+	Missense_Mutation	SNP	C	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr9:32541815C>G	uc003zrb.2	-	3	2875	c.2708G>C	c.(2707-2709)CGT>CCT	p.R903P	TOPORS_uc003zrc.2_Missense_Mutation_p.R836P	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	903	Interaction with UBE2I.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		AACTGGGGAACGTGAAGCATT	0.323000													58	90					0	0	0.000147903	0	0
VCP	7415	broad.mit.edu	37	9	35061057	35061057	+	Silent	SNP	A	G	G			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr9:35061057A>G	uc003zvy.2	-	11	1703	c.1314T>C	c.(1312-1314)GAT>GAC	p.D438D	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_Silent_p.D107D|VCP_uc010mki.1_Silent_p.D393D	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	438					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TGACCTCGGCATCAATGGTCT	0.537000													111	108					0	0	0.000147903	0	0
TMEM2	23670	broad.mit.edu	37	9	74313090	74313090	+	Missense_Mutation	SNP	G	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr9:74313090G>T	uc011lsa.1	-	20	3948	c.3408C>A	c.(3406-3408)AGC>AGA	p.S1136R	TMEM2_uc011lrz.1_Missense_Mutation_p.S129R|TMEM2_uc010mos.2_Missense_Mutation_p.S1073R|TMEM2_uc011lsb.1_RNA|TMEM2_uc004aik.2_5'UTR	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	1136						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		CATGCCTGTGGCTTTTGGCTT	0.413000													39	73					2.00842e-17	1.0054e-15	8.96297e-05	1	0
FLJ46321	389763	broad.mit.edu	37	9	84609482	84609482	+	Missense_Mutation	SNP	T	C	C			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr9:84609482T>C	uc004amn.2	+	4	4144	c.4097T>C	c.(4096-4098)ATA>ACA	p.I1366T		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1366						integral to membrane					0						AAACCCAGCATATCATATGAA	0.433000													10	12					0	0	3.86212e-05	0	0
PAPPA	5069	broad.mit.edu	37	9	118949550	118949550	+	Missense_Mutation	SNP	G	T	T			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr9:118949550G>T	uc004bjn.2	+	2	914	c.533G>T	c.(532-534)CGA>CTA	p.R178L	PAPPA_uc011lxp.1_5'UTR|PAPPA_uc011lxq.1_5'UTR	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	178					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						AAGACAGACCGAGCCCGGCAA	0.532000													26	39					2.79863e-10	1.34403e-08	9.22233e-05	1	0
FAM123B	139285	broad.mit.edu	37	X	63411696	63411696	+	Missense_Mutation	SNP	G	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chrX:63411696G>A	uc004dvo.2	-	2	1744	c.1471C>T	c.(1471-1473)CGC>TGC	p.R491C		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	491					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CAATCCCTGCGGACAAGCCCC	0.522000													16	4					0	0	9.7654e-05	0	0
UBR4	23352	broad.mit.edu	37	1	19448476	19448477	+	Frame_Shift_Ins	INS	-	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr1:19448476_19448477insA	uc001bbi.2	-	67	9850_9851	c.9846_9847insT	c.(9844-9849)ATTGCCfs	p.I3282fs	UBR4_uc001bbk.1_Frame_Shift_Ins_p.I929fs	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3282_3283					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CGCTGGGCGGCAATCTCTGCAC	0.450													30	45	---	---	---	---					
RRP12	23223	broad.mit.edu	37	10	99120314	99120314	+	Frame_Shift_Del	DEL	G	-	-			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr10:99120314delG	uc001knf.2	-	31	3768	c.3629delC	c.(3628-3630)CCTfs	p.P1210fs	RRP12_uc001kne.2_Frame_Shift_Del_p.P225fs|RRP12_uc009xvl.2_Frame_Shift_Del_p.P327fs|RRP12_uc009xvm.2_Frame_Shift_Del_p.P928fs|RRP12_uc010qou.1_Frame_Shift_Del_p.P1149fs|RRP12_uc009xvn.2_Frame_Shift_Del_p.P1110fs	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	1210						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		TTGGTACTGAGGGGGTATCTC	0.557													39	43	---	---	---	---					
SCN8A	6334	broad.mit.edu	37	12	52145329	52145329	+	Frame_Shift_Del	DEL	C	-	-			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr12:52145329delC	uc001ryw.2	+	14	2500	c.2322delC	c.(2320-2322)CACfs	p.H774fs	SCN8A_uc010snl.1_Frame_Shift_Del_p.H639fs|SCN8A_uc001ryy.2_Frame_Shift_Del_p.H639fs	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	774	II.				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CAATGGAGCACCATCCTATGA	0.418													36	74	---	---	---	---					
TMPO	7112	broad.mit.edu	37	12	98941479	98941479	+	Frame_Shift_Del	DEL	A	-	-			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr12:98941479delA	uc001tfj.2	+	9	1445	c.1208delA	c.(1207-1209)GAAfs	p.E403fs	TMPO_uc001tfk.2_Frame_Shift_Del_p.E294fs|TMPO_uc001tfl.2_RNA	NM_001032283	NP_001027454	P42167	LAP2B_HUMAN	thymopoietin isoform beta	403	Nucleoplasmic (Potential).					integral to membrane|nuclear inner membrane	DNA binding|lamin binding			ovary(2)	2						GTCAAGTCAGAAAAGACAAAA	0.408													47	62	---	---	---	---					
SRRM4	84530	broad.mit.edu	37	12	119568567	119568567	+	Frame_Shift_Del	DEL	C	-	-			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr12:119568567delC	uc001txa.1	+	8	991	c.699delC	c.(697-699)AGCfs	p.S233fs		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	233	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						GCAAGGACAGCCCTGAGGCCC	0.657													9	31	---	---	---	---					
BCL11B	64919	broad.mit.edu	37	14	99641544	99641546	+	In_Frame_Del	DEL	CTC	-	-			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr14:99641544_99641546delCTC	uc001yga.2	-	4	1894_1896	c.1627_1629delGAG	c.(1627-1629)GAGdel	p.E543del	BCL11B_uc001ygb.2_In_Frame_Del_p.E472del	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	543	Glu-rich.					nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		CCAGTAGCAGctcctcctcctcc	0.517			T	TLX3	T-ALL								3	4	---	---	---	---					
LENG8	114823	broad.mit.edu	37	19	54963430	54963444	+	In_Frame_Del	DEL	GTGGCCAGTGCACAG	-	-			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr19:54963430_54963444delGTGGCCAGTGCACAG	uc002qfv.1	+	3	343_357	c.199_213delGTGGCCAGTGCACAG	c.(199-213)GTGGCCAGTGCACAGdel	p.VASAQ67del	LENG8_uc002qfw.2_In_Frame_Del_p.VASAQ67del			Q96PV6	LENG8_HUMAN	RecName: Full=Leukocyte receptor cluster member 8;	67_71							protein binding			central_nervous_system(1)|pancreas(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		CAATGGGCCTGTGGCCAGTGCACAGGTGAGAAGGC	0.642													9	19	---	---	---	---					
PRPF40A	55660	broad.mit.edu	37	2	153573856	153573857	+	Frame_Shift_Ins	INS	-	CCATTTCA	CCATTTCA			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr2:153573856_153573857insCCATTTCA	uc002tyi.2	-	1	65_66	c.52_53insTGAAATGG	c.(52-54)GAGfs	p.E18fs	ARL6IP6_uc002tyn.2_5'Flank|ARL6IP6_uc002tym.2_5'Flank|ARL6IP6_uc002tyo.2_5'Flank|PRPF40A_uc002tyh.3_Intron|PRPF40A_uc010zcd.1_Intron|PRPF40A_uc002tyj.2_Intron|PRPF40A_uc002tyl.1_Frame_Shift_Ins_p.E18fs	NM_017892	NP_060362	O75400	PR40A_HUMAN	formin binding protein 3	18					mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding				0						AGGATGGCTCTCCATTTCACTC	0.663													12	51	---	---	---	---					
CDK13	8621	broad.mit.edu	37	7	40117701	40117701	+	Frame_Shift_Del	DEL	T	-	-			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr7:40117701delT	uc003thh.3	+	10	3160	c.2878delT	c.(2878-2880)TTAfs	p.L960fs	CDK13_uc003thi.3_Frame_Shift_Del_p.L960fs|CDK13_uc003thj.2_Frame_Shift_Del_p.L11fs	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	960	Protein kinase.				alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						TCGTCGAAAGTTAAGAGAAGA	0.348													64	75	---	---	---	---					
RHPN1	114822	broad.mit.edu	37	8	144462787	144462787	+	Frame_Shift_Del	DEL	G	-	-			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chr8:144462787delG	uc003yyb.2	+	11	1378	c.1245delG	c.(1243-1245)CTGfs	p.L415fs		NM_052924	NP_443156	Q8TCX5	RHPN1_HUMAN	rhophilin 1	440	BRO1.				signal transduction	intracellular				large_intestine(1)	1	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			GTGCCATCCTGGGGCAGGAGG	0.697													2	4	---	---	---	---					
BMP15	9210	broad.mit.edu	37	X	50654047	50654047	+	Frame_Shift_Del	DEL	C	-	-			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	e6107469-78da-4831-a87a-9fc0dbccbd8e	g.chrX:50654047delC	uc011mnw.1	+	1	264	c.264delC	c.(262-264)CGCfs	p.R88fs		NM_005448	NP_005439	O95972	BMP15_HUMAN	bone morphogenetic protein 15 precursor	88					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			ovary(2)	2	Ovarian(276;0.236)					GAGAGAACCGCACCATTGGGG	0.592													2	4	---	---	---	---					
UBR4	23352	broad.mit.edu	37	1	19448476	19448477	+	Frame_Shift_Ins	INS	-	A	A			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr1:19448476_19448477insA	uc001bbi.2	-	67	9850_9851	c.9846_9847insT	c.(9844-9849)ATTGCCfs	p.I3282fs	UBR4_uc001bbk.1_Frame_Shift_Ins_p.I929fs	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3282_3283					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CGCTGGGCGGCAATCTCTGCAC	0.450													30	45	---	---	---	---					
RRP12	23223	broad.mit.edu	37	10	99120314	99120314	+	Frame_Shift_Del	DEL	G	-	-			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr10:99120314delG	uc001knf.2	-	31	3768	c.3629delC	c.(3628-3630)CCTfs	p.P1210fs	RRP12_uc001kne.2_Frame_Shift_Del_p.P225fs|RRP12_uc009xvl.2_Frame_Shift_Del_p.P327fs|RRP12_uc009xvm.2_Frame_Shift_Del_p.P928fs|RRP12_uc010qou.1_Frame_Shift_Del_p.P1149fs|RRP12_uc009xvn.2_Frame_Shift_Del_p.P1110fs	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	1210						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		TTGGTACTGAGGGGGTATCTC	0.557													39	43	---	---	---	---					
SCN8A	6334	broad.mit.edu	37	12	52145329	52145329	+	Frame_Shift_Del	DEL	C	-	-			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr12:52145329delC	uc001ryw.2	+	14	2500	c.2322delC	c.(2320-2322)CACfs	p.H774fs	SCN8A_uc010snl.1_Frame_Shift_Del_p.H639fs|SCN8A_uc001ryy.2_Frame_Shift_Del_p.H639fs	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	774	II.				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CAATGGAGCACCATCCTATGA	0.418													36	74	---	---	---	---					
TMPO	7112	broad.mit.edu	37	12	98941479	98941479	+	Frame_Shift_Del	DEL	A	-	-			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr12:98941479delA	uc001tfj.2	+	9	1445	c.1208delA	c.(1207-1209)GAAfs	p.E403fs	TMPO_uc001tfk.2_Frame_Shift_Del_p.E294fs|TMPO_uc001tfl.2_RNA	NM_001032283	NP_001027454	P42167	LAP2B_HUMAN	thymopoietin isoform beta	403	Nucleoplasmic (Potential).					integral to membrane|nuclear inner membrane	DNA binding|lamin binding			ovary(2)	2						GTCAAGTCAGAAAAGACAAAA	0.408													47	62	---	---	---	---					
SRRM4	84530	broad.mit.edu	37	12	119568567	119568567	+	Frame_Shift_Del	DEL	C	-	-			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr12:119568567delC	uc001txa.1	+	8	991	c.699delC	c.(697-699)AGCfs	p.S233fs		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	233	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						GCAAGGACAGCCCTGAGGCCC	0.657													9	31	---	---	---	---					
LENG8	114823	broad.mit.edu	37	19	54963430	54963444	+	In_Frame_Del	DEL	GTGGCCAGTGCACAG	-	-			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr19:54963430_54963444delGTGGCCAGTGCACAG	uc002qfv.1	+	3	343_357	c.199_213delGTGGCCAGTGCACAG	c.(199-213)GTGGCCAGTGCACAGdel	p.VASAQ67del	LENG8_uc002qfw.2_In_Frame_Del_p.VASAQ67del			Q96PV6	LENG8_HUMAN	RecName: Full=Leukocyte receptor cluster member 8;	67_71							protein binding			central_nervous_system(1)|pancreas(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		CAATGGGCCTGTGGCCAGTGCACAGGTGAGAAGGC	0.642													9	19	---	---	---	---					
PRPF40A	55660	broad.mit.edu	37	2	153573856	153573857	+	Frame_Shift_Ins	INS	-	CCATTTCA	CCATTTCA			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr2:153573856_153573857insCCATTTCA	uc002tyi.2	-	1	65_66	c.52_53insTGAAATGG	c.(52-54)GAGfs	p.E18fs	ARL6IP6_uc002tyn.2_5'Flank|ARL6IP6_uc002tym.2_5'Flank|ARL6IP6_uc002tyo.2_5'Flank|PRPF40A_uc002tyh.3_Intron|PRPF40A_uc010zcd.1_Intron|PRPF40A_uc002tyj.2_Intron|PRPF40A_uc002tyl.1_Frame_Shift_Ins_p.E18fs	NM_017892	NP_060362	O75400	PR40A_HUMAN	formin binding protein 3	18					mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding				0						AGGATGGCTCTCCATTTCACTC	0.663													12	51	---	---	---	---					
CDK13	8621	broad.mit.edu	37	7	40117701	40117701	+	Frame_Shift_Del	DEL	T	-	-			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr7:40117701delT	uc003thh.3	+	10	3160	c.2878delT	c.(2878-2880)TTAfs	p.L960fs	CDK13_uc003thi.3_Frame_Shift_Del_p.L960fs|CDK13_uc003thj.2_Frame_Shift_Del_p.L11fs	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	960	Protein kinase.				alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						TCGTCGAAAGTTAAGAGAAGA	0.348													64	75	---	---	---	---					
RHPN1	114822	broad.mit.edu	37	8	144462787	144462787	+	Frame_Shift_Del	DEL	G	-	-			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chr8:144462787delG	uc003yyb.2	+	11	1378	c.1245delG	c.(1243-1245)CTGfs	p.L415fs		NM_052924	NP_443156	Q8TCX5	RHPN1_HUMAN	rhophilin 1	440	BRO1.				signal transduction	intracellular				large_intestine(1)	1	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			GTGCCATCCTGGGGCAGGAGG	0.697													2	4	---	---	---	---					
BMP15	9210	broad.mit.edu	37	X	50654047	50654047	+	Frame_Shift_Del	DEL	C	-	-			TCGA-DZ-6133-01A-11D-1961-08	TCGA-DZ-6133-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac1245d-4f00-4d28-bbc0-cdaf6beba2d0	ba8e73ba-4168-46ed-8ae1-fbbc2848f3f1	g.chrX:50654047delC	uc011mnw.1	+	1	264	c.264delC	c.(262-264)CGCfs	p.R88fs		NM_005448	NP_005439	O95972	BMP15_HUMAN	bone morphogenetic protein 15 precursor	88					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			ovary(2)	2	Ovarian(276;0.236)					GAGAGAACCGCACCATTGGGG	0.592													2	4	---	---	---	---					
