Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AHDC1	27245	broad.mit.edu	37	1	27875947	27875947	+	Missense_Mutation	SNP	T	G	G			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr1:27875947T>G	uc009vsy.2	-	6	3649	c.2680A>C	c.(2680-2682)AAG>CAG	p.K894Q	AHDC1_uc009vsz.1_Missense_Mutation_p.K894Q	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	894							DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GGGCTGGCCTTGGCTCCCCGG	0.716000													28	18					0	0	0.041601	0	0
USP24	23358	broad.mit.edu	37	1	55569689	55569689	+	Missense_Mutation	SNP	T	C	C			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr1:55569689T>C	uc001cyg.3	-	39	4405	c.4405A>G	c.(4405-4407)AGT>GGT	p.S1469G		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	1629					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						TTCGCTGTACTACACCTAGAA	0.328000													5	9					0	0	0.021553	0	0
FLG	2312	broad.mit.edu	37	1	152279672	152279672	+	Nonsense_Mutation	SNP	C	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr1:152279672C>A	uc001ezu.1	-	3	7726	c.7690G>T	c.(7690-7692)GGA>TGA	p.G2564*		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2564	Ser-rich.|Filaggrin 15.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AAACTGGATCCCCAGTTCCTG	0.582000									Ichthyosis				196	177					8.39021e-101	1.05389e-100	0.048971	1	0
MYOC	4653	broad.mit.edu	37	1	171605341	171605341	+	Silent	SNP	G	C	C			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr1:171605341G>C	uc001ghu.2	-	3	1261	c.1239C>G	c.(1237-1239)CTC>CTG	p.L413L	MYOC_uc010pmk.1_Silent_p.L355L	NM_000261	NP_000252	Q99972	MYOC_HUMAN	myocilin precursor	413	Olfactomedin-like.				anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			lung(1)	1	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					AGGTTTGTTCGAGTTCCAGAT	0.522000													53	77					0	0	0.048971	0	0
OBSCN	84033	broad.mit.edu	37	1	228473855	228473855	+	Silent	SNP	G	C	C			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr1:228473855G>C	uc009xez.1	+	34	9125	c.9081G>C	c.(9079-9081)CGG>CGC	p.R3027R	OBSCN_uc001hsn.2_Silent_p.R3027R|OBSCN_uc001hsq.1_Silent_p.R283R	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3027	Ig-like 30.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TCCGTTGCCGGATCTCCCCGG	0.627000													11	5					0	0	0.080935	0	0
ABLIM1	3983	broad.mit.edu	37	10	116225561	116225561	+	Missense_Mutation	SNP	A	G	G			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr10:116225561A>G	uc010qsg.1	-	12	1436	c.1337T>C	c.(1336-1338)ATG>ACG	p.M446T	ABLIM1_uc010qsh.1_Missense_Mutation_p.M414T|ABLIM1_uc010qsi.1_Missense_Mutation_p.M386T|ABLIM1_uc010qsk.1_Missense_Mutation_p.M370T|ABLIM1_uc009xyp.2_Missense_Mutation_p.M408T|ABLIM1_uc010qsf.1_Missense_Mutation_p.M158T|ABLIM1_uc009xyn.2_Missense_Mutation_p.M97T|ABLIM1_uc010qsj.1_Missense_Mutation_p.M123T|ABLIM1_uc009xyo.2_Missense_Mutation_p.M294T	NM_002313	NP_002304	O14639	ABLM1_HUMAN	actin-binding LIM protein 1 isoform a	446					axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(1)	1		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		CCGATGGATCATCCGATCCCG	0.557000													74	71					0	0	0.048971	0	0
LOC650368	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr11:3427845C>T	uc010qxs.1	+	9		c.838C>T			LOC650368_uc001lxx.2_RNA|LOC650368_uc001lxy.2_RNA	NR_024248				Homo sapiens cDNA FLJ41654 fis, clone FEBRA2025463, weakly  similar to Homo sapiens HMT-1 mRNA for beta-1,4 mannosyltransferase.												0						CTTCAAGTGGCAGGAGCAGAA	0.587000													4	61					0	0	0.009096	0	0
TRIM22	10346	broad.mit.edu	37	11	5717510	5717510	+	Silent	SNP	C	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr11:5717510C>T	uc001mbr.2	+	2	325	c.48C>T	c.(46-48)CCC>CCT	p.P16P	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Silent_p.P16P|TRIM22_uc009yes.2_Silent_p.P16P|TRIM22_uc010qzm.1_5'UTR|TRIM22_uc009yeu.2_5'UTR	NM_006074	NP_006065	Q8IYM9	TRI22_HUMAN	tripartite motif-containing 22	16	RING-type.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding				0		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		TGACCTGCCCCATCTGCCTGG	0.502000													31	27					0	0	0.059317	0	0
GPR137	56834	broad.mit.edu	37	11	64056826	64056826	+	Missense_Mutation	SNP	C	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr11:64056826C>T	uc001nzg.1	+	8	1551	c.1243C>T	c.(1243-1245)CCG>TCG	p.P415S	GPR137_uc010rni.1_Missense_Mutation_p.P473S|GPR137_uc001nzf.2_3'UTR|GPR137_uc001nzi.2_3'UTR|GPR137_uc010rnj.1_3'UTR|KCNK4_uc009ypl.1_5'Flank|KCNK4_uc001nzj.1_5'Flank|KCNK4_uc001nzk.1_5'Flank|KCNK4_uc010rnk.1_5'Flank|KCNK4_uc001nzl.1_5'Flank|KCNK4_uc001nzm.3_5'Flank|KCNK4_uc001nzn.1_5'Flank	NM_020155	NP_064540	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	415	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(1)	1						TGAGCTTGTGCCGTCCCCCTA	0.647000													4	112					0	0	0.009096	0	0
OR2AT4	341152	broad.mit.edu	37	11	74800733	74800733	+	Missense_Mutation	SNP	G	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr11:74800733G>A	uc010rro.1	-	1	26	c.26C>T	c.(25-27)TCA>TTA	p.S9L		NM_001005285	NP_001005285	A6NND4	O2AT4_HUMAN	olfactory receptor, family 2, subfamily AT,	9	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GCCATCCACTGATTCATTACA	0.473000													32	34					0	0	0.080422	0	0
MYO7A	4647	broad.mit.edu	37	11	76867021	76867021	+	Silent	SNP	C	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr11:76867021C>T	uc001oyb.2	+	5	626	c.354C>T	c.(352-354)CAC>CAT	p.H118H	MYO7A_uc010rsl.1_Silent_p.H118H|MYO7A_uc010rsm.1_Silent_p.H107H|MYO7A_uc001oyc.2_Silent_p.H118H	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	118	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						CGCCAGAGCACATCCGCCAGT	0.562000													7	3					0	0	0.047766	0	0
GAB2	9846	broad.mit.edu	37	11	77991912	77991912	+	Silent	SNP	G	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr11:77991912G>A	uc001ozh.2	-	2	111	c.111C>T	c.(109-111)GGC>GGT	p.G37G	GAB2_uc001ozg.2_5'UTR	NM_080491	NP_536739	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2 isoform a	37	PH.				osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity			ovary(5)|lung(1)	6	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			CGCTCATCCGGCCACTCCGCA	0.463000													5	129					0	0	0.029380	0	0
C12orf26	84190	broad.mit.edu	37	12	82752495	82752495	+	Missense_Mutation	SNP	G	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr12:82752495G>A	uc001szq.2	+	1	172	c.151G>A	c.(151-153)GTC>ATC	p.V51I	CCDC59_uc001szp.3_5'Flank	NM_032230	NP_115606	Q8N6Q8	CL026_HUMAN	hypothetical protein LOC84190	51											0						GGAGGAGCTGGTCGACTTGCC	0.602000											OREG0022008	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	56					0	0	0.045705	0	0
C12orf63	374467	broad.mit.edu	37	12	97137640	97137640	+	Silent	SNP	A	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr12:97137640A>T	uc001tet.1	+	21	2862	c.2784A>T	c.(2782-2784)ACA>ACT	p.T928T		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	928										skin(6)|ovary(1)	7						CTTCAAAAACAGGAAAATTAA	0.393000													35	34					0	0	0.080422	0	0
SBNO1	55206	broad.mit.edu	37	12	123780522	123780522	+	Missense_Mutation	SNP	G	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr12:123780522G>A	uc010tap.1	-	31	4115	c.4115C>T	c.(4114-4116)GCG>GTG	p.A1372V	SBNO1_uc009zxv.2_RNA|SBNO1_uc010tao.1_Missense_Mutation_p.A1371V|SBNO1_uc010taq.1_Missense_Mutation_p.A323V	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1372							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		CTGTTGGACCGCAAGCTGTTG	0.433000													6	279					0	0	0.021553	0	0
C13orf23	80209	broad.mit.edu	37	13	39587414	39587414	+	Missense_Mutation	SNP	C	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr13:39587414C>A	uc001uwy.2	-	11	2848	c.1975G>T	c.(1975-1977)GCA>TCA	p.A659S	C13orf23_uc001uwz.2_Missense_Mutation_p.A637S	NM_025138	NP_079414	Q86XN7	CM023_HUMAN	hypothetical protein LOC80209 isoform 1	659	Ser-rich.									ovary(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)	5		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;3.7e-08)|Epithelial(112;4.28e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00114)|BRCA - Breast invasive adenocarcinoma(63;0.00366)|GBM - Glioblastoma multiforme(144;0.0146)		CCTGACAATGCAGGATTAAGG	0.478000													46	45					8.20599e-20	9.71513e-20	0.042209	1	0
MYCBP2	23077	broad.mit.edu	37	13	77799654	77799654	+	Missense_Mutation	SNP	T	C	C			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr13:77799654T>C	uc001vkf.2	-	20	2750	c.2659A>G	c.(2659-2661)AAA>GAA	p.K887E	MYCBP2_uc010aev.2_Missense_Mutation_p.K291E	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	887	RCC1 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GTTGTGATTTTGCTTGCATCC	0.413000													55	67					0	0	0.048971	0	0
COCH	1690	broad.mit.edu	37	14	31355476	31355476	+	Missense_Mutation	SNP	T	C	C			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr14:31355476T>C	uc001wqr.2	+	11	1515	c.1435T>C	c.(1435-1437)TAT>CAT	p.Y479H	COCH_uc001wqp.2_Missense_Mutation_p.Y479H|COCH_uc001wqq.3_Missense_Mutation_p.Y479H|uc001wqs.2_RNA|COCH_uc001wqt.1_Missense_Mutation_p.Y330H	NM_004086	NP_004077	O43405	COCH_HUMAN	cochlin precursor	479	VWFA 2.				sensory perception of sound	proteinaceous extracellular matrix				pancreas(1)|central_nervous_system(1)|skin(1)	3	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		TGGGCAGTCCTATGATGATGT	0.453000													34	38					0	0	0.054565	0	0
FERMT2	10979	broad.mit.edu	37	14	53360052	53360052	+	Missense_Mutation	SNP	T	C	C			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr14:53360052T>C	uc001xad.2	-	4	540	c.485A>G	c.(484-486)GAG>GGG	p.E162G	FERMT2_uc001xac.2_Missense_Mutation_p.E162G|FERMT2_uc001xae.2_Missense_Mutation_p.E162G|FERMT2_uc001xaf.2_Missense_Mutation_p.E162G	NM_006832	NP_006823	Q96AC1	FERM2_HUMAN	fermitin family homolog 2 isoform 1	162					actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding				0	Breast(41;0.0342)					TTCAAGTGCCTCATCTTCAGA	0.413000													62	89					0	0	0.048971	0	0
ADAM6	8755	broad.mit.edu	37	14	106110991	106110991	+	RNA	SNP	A	G	G			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr14:106110991A>G	uc010tyt.1	-	3640		c.60770T>C			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_RNA					Parts of antibodies, mostly variable regions.												0						GCCGCTGGTCAGAGCGCCTGA	0.657000													13	17					0	0	0.105934	0	0
MRPL46	26589	broad.mit.edu	37	15	89008985	89008985	+	Missense_Mutation	SNP	A	G	G			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr15:89008985A>G	uc002bmj.2	-	2	273	c.248T>C	c.(247-249)CTG>CCG	p.L83P	MRPL46_uc002bmi.1_5'UTR|MRPL46_uc002bmk.2_Missense_Mutation_p.L83P|MRPS11_uc002bmm.2_5'Flank|MRPS11_uc002bml.2_5'Flank|MRPS11_uc002bmn.2_5'Flank|MRPS11_uc010bnj.2_5'Flank	NM_022163	NP_071446	Q9H2W6	RM46_HUMAN	mitochondrial ribosomal protein L46 precursor	83						mitochondrion|ribosome	hydrolase activity			central_nervous_system(1)	1	Lung NSC(78;0.203)		BRCA - Breast invasive adenocarcinoma(143;0.188)			GTCTGAATACAGGCTTCTCTC	0.388000													3	116					0	0	0.004672	0	0
CRAMP1L	57585	broad.mit.edu	37	16	1718163	1718163	+	Silent	SNP	C	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr16:1718163C>T	uc010uvh.1	+	17	3303	c.3303C>T	c.(3301-3303)ATC>ATT	p.I1101I	CRAMP1L_uc002cmf.2_RNA	NM_020825	NP_065876	Q96RY5	CRML_HUMAN	Crm, cramped-like	1101	Ser-rich.					nucleus	DNA binding				0						GCGACTCCATCATTGAGATCG	0.607000													28	69					0	0	0.045705	0	0
MKL2	57496	broad.mit.edu	37	16	14342808	14342808	+	Missense_Mutation	SNP	C	G	G			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr16:14342808C>G	uc010uza.1	+	13	2428	c.2273C>G	c.(2272-2274)ACT>AGT	p.T758S	MKL2_uc002dcg.2_Missense_Mutation_p.T708S|MKL2_uc002dcj.2_Missense_Mutation_p.T3S	NM_014048	NP_054767	Q9ULH7	MKL2_HUMAN	megakaryoblastic leukemia 2 protein	747	Gln-rich.				cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			ovary(3)|kidney(1)|pancreas(1)	5						GGAATGCAGACTCAGCCTCAG	0.448000													58	33					0	0	0.048971	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53636027	53636027	+	Missense_Mutation	SNP	C	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr16:53636027C>A	uc002ehp.2	-	27	3973	c.3909G>T	c.(3907-3909)CAG>CAT	p.Q1303H	RPGRIP1L_uc002eho.3_Missense_Mutation_p.Q1223H|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.Q1257H|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.Q1269H	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	1303					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				TGTAGACAGACTGGAGGGCAT	0.468000													62	29					5.52965e-18	6.4722e-18	0.048971	1	0
ELMO3	79767	broad.mit.edu	37	16	67236330	67236330	+	Missense_Mutation	SNP	T	G	G			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr16:67236330T>G	uc002esa.2	+	14	1494	c.1451T>G	c.(1450-1452)ATG>AGG	p.M484R	ELMO3_uc002esb.2_Missense_Mutation_p.M467R|ELMO3_uc002esc.2_Missense_Mutation_p.M318R|uc010vjf.1_5'Flank|MIR328_hsa-mir-328|MI0000804_5'Flank	NM_024712	NP_078988	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	431	ELMO.				apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		TTCTCACCCATGTTCTTCGGC	0.597000													17	179					0	0	0.049695	0	0
Unknown	0	broad.mit.edu	37	17	16734855	16734855	+	Missense_Mutation	SNP	C	T	T	rs688852	by1000genomes	TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr17:16734855C>T	uc010vwr.1	-	3	720	c.278G>A	c.(277-279)CGG>CAG	p.R93Q						SubName: Full=cDNA FLJ53570, highly similar to Keratin, type I cytoskeletal 16;																		CACAGTCTGCCGCAGGGCCAG	0.632000													3	26					0	0	0.014758	0	0
CDK5RAP3	80279	broad.mit.edu	37	17	46051766	46051766	+	Missense_Mutation	SNP	G	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr17:46051766G>A	uc002imr.2	+	5	370	c.286G>A	c.(286-288)GAT>AAT	p.D96N	CDK5RAP3_uc010wlc.1_Missense_Mutation_p.D116N|CDK5RAP3_uc002imq.1_5'UTR|CDK5RAP3_uc002imu.2_5'UTR|CDK5RAP3_uc002ims.2_5'UTR|CDK5RAP3_uc002imv.2_5'UTR|CDK5RAP3_uc002imw.2_5'UTR|CDK5RAP3_uc002imx.2_5'UTR	NM_176096	NP_788276	Q96JB5	CK5P3_HUMAN	CDK5 regulatory subunit associated protein 3	96					brain development|regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation		neuronal Cdc2-like kinase binding				0						TCTTACTCAGGATTGGCAGGA	0.493000													9	99					0	0	0.105934	0	0
APPBP2	10513	broad.mit.edu	37	17	58525181	58525181	+	Missense_Mutation	SNP	C	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr17:58525181C>A	uc002iys.1	-	13	1807	c.1519G>T	c.(1519-1521)GGT>TGT	p.G507C	APPBP2_uc010ddl.1_Missense_Mutation_p.G436C	NM_006380	NP_006371	Q92624	APBP2_HUMAN	amyloid beta precursor protein-binding protein	507					intracellular protein transport	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|nucleus	microtubule motor activity|protein binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.67e-13)|all cancers(12;1.44e-11)|Colorectal(3;0.01)			TAGCCCTCACCAAAAAGTTTC	0.308000													52	70					5.2118e-15	6.03163e-15	0.048971	1	0
KIAA1012	22878	broad.mit.edu	37	18	29488737	29488737	+	Missense_Mutation	SNP	T	G	G			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr18:29488737T>G	uc002kxc.3	-	7	1466	c.1102A>C	c.(1102-1104)ATT>CTT	p.I368L	KIAA1012_uc002kxb.3_Missense_Mutation_p.I314L|KIAA1012_uc002kxd.3_RNA|KIAA1012_uc002kxe.2_Missense_Mutation_p.I368L	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	368					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						AATTGCCTAATTGTTTTCTCT	0.269000													28	38					0	0	0.030593	0	0
CNDP2	55748	broad.mit.edu	37	18	72179734	72179734	+	Missense_Mutation	SNP	C	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr18:72179734C>A	uc002llm.1	+	7	871	c.709C>A	c.(709-711)CAT>AAT	p.H237N	CNDP2_uc002lln.1_Missense_Mutation_p.H153N|CNDP2_uc010dqs.2_Missense_Mutation_p.H73N	NM_018235	NP_060705	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2	237						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			ovary(2)|skin(1)	3		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		GGGCTCGGTGCATGAGGCCAT	0.562000													31	51					4.34311e-12	4.97044e-12	0.059317	1	0
ZNF236	7776	broad.mit.edu	37	18	74561610	74561610	+	Missense_Mutation	SNP	G	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr18:74561610G>A	uc002lmi.2	+	2	376	c.178G>A	c.(178-180)GAG>AAG	p.E60K	ZNF236_uc002lmj.2_RNA|ZNF236_uc002lmk.1_Missense_Mutation_p.E60K	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	60					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		GAGGGATCACGAGCGAAATGA	0.358000													33	44					0	0	0.059317	0	0
MYO1F	4542	broad.mit.edu	37	19	8609279	8609279	+	Missense_Mutation	SNP	C	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr19:8609279C>A	uc002mkg.2	-	14	1540	c.1426G>T	c.(1426-1428)GAC>TAC	p.D476Y		NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	476	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						AGTGTCTGGTCTGCTCCCCCG	0.677000													21	21					3.62473e-10	4.10272e-10	0.062417	1	0
CACNA1A	773	broad.mit.edu	37	19	13397703	13397703	+	Missense_Mutation	SNP	C	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr19:13397703C>T	uc010dze.2	-	20	3406	c.3170G>A	c.(3169-3171)CGC>CAC	p.R1057H	CACNA1A_uc010dzc.2_Missense_Mutation_p.R582H|CACNA1A_uc002mwy.3_Missense_Mutation_p.R1056H|CACNA1A_uc010xne.1_Missense_Mutation_p.R585H	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1057	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TGGGTCTTGGCGGCCCAGGTC	0.642000													7	40					0	0	0.038147	0	0
ZNF780B	163131	broad.mit.edu	37	19	40541550	40541550	+	Missense_Mutation	SNP	G	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr19:40541550G>T	uc002omu.2	-	5	1281	c.1216C>A	c.(1216-1218)CAA>AAA	p.Q406K	ZNF780B_uc002omv.2_Missense_Mutation_p.Q258K	NM_001005851	NP_001005851	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	406	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CTCTGGTGTTGAATAAGGTTT	0.358000													71	87					3.19223e-45	3.91429e-45	0.048971	1	0
ATF5	22809	broad.mit.edu	37	19	50434060	50434060	+	Translation_Start_Site	SNP	G	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr19:50434060G>A	uc010enq.1	+	3	520	c.-47G>A	c.(-49--45)TGGTG>TGATG		IL4I1_uc002pqv.1_5'Flank|IL4I1_uc010eno.1_5'Flank|IL4I1_uc002pqw.1_5'Flank|IL4I1_uc002pqu.1_5'Flank|NUP62_uc002pqx.2_5'Flank|NUP62_uc002pqy.2_5'Flank|NUP62_uc002pqz.2_5'Flank|NUP62_uc002pra.2_5'Flank|NUP62_uc002prb.2_5'Flank|NUP62_uc002prc.2_5'Flank|ATF5_uc002prd.2_Translation_Start_Site	NM_012068	NP_036200	Q9Y2D1	ATF5_HUMAN	activating transcription factor 5						regulation of transcription from RNA polymerase II promoter	cytoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			skin(2)	2		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00221)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		CCAGCTGCTGGTGCAGCCTCT	0.637000													7	1					0	0	0.029380	0	0
ZNF320	162967	broad.mit.edu	37	19	53384942	53384942	+	Missense_Mutation	SNP	A	G	G			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr19:53384942A>G	uc002qag.2	-	4	628	c.437T>C	c.(436-438)TTG>TCG	p.L146S	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Missense_Mutation_p.L92S|ZNF320_uc002qai.2_Missense_Mutation_p.L146S	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		TCGCAAATGCAAATGAAATCT	0.348000													69	91					0	0	0.048971	0	0
ZSCAN22	342945	broad.mit.edu	37	19	58849878	58849878	+	Missense_Mutation	SNP	G	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr19:58849878G>A	uc002qsc.2	+	3	809	c.662G>A	c.(661-663)CGT>CAT	p.R221H	ZSCAN22_uc010yhz.1_Missense_Mutation_p.V216M	NM_181846	NP_862829	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	221					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		CAGCGTGGCCGTGAATCTGGT	0.512000													7	238					0	0	0.038147	0	0
BIRC6	57448	broad.mit.edu	37	2	32667276	32667276	+	Missense_Mutation	SNP	A	C	C			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr2:32667276A>C	uc010ezu.2	+	18	4222	c.4088A>C	c.(4087-4089)CAT>CCT	p.H1363P		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1363					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GCTGGAGTTCATTCAAATGGA	0.383000													34	28					0	0	0.050027	0	0
HNRPLL	92906	broad.mit.edu	37	2	38791355	38791355	+	Missense_Mutation	SNP	T	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr2:38791355T>A	uc002rqw.2	-	13	2008	c.1598A>T	c.(1597-1599)AAG>ATG	p.K533M	HNRPLL_uc002rqv.2_Missense_Mutation_p.K228M|HNRPLL_uc002rqx.2_Missense_Mutation_p.K528M	NM_138394	NP_612403	Q8WVV9	HNRLL_HUMAN	heterogeneous nuclear ribonucleoprotein L-like	533					mRNA processing|positive regulation of RNA splicing	nucleus|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding			skin(1)	1		all_hematologic(82;0.248)				AAAGCAAAGCTTCAATGTATA	0.289000													57	62					0	0	0.048971	0	0
SLC3A1	6519	broad.mit.edu	37	2	44508525	44508525	+	Splice_Site	SNP	G	C	C			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr2:44508525G>C	uc002ruc.3	+	3	689	c.611_splice	c.e3-1	p.G204_splice	SLC3A1_uc002rty.2_Splice_Site_p.G204_splice|SLC3A1_uc002rtz.2_Splice_Site_p.G204_splice|SLC3A1_uc002rua.2_Splice_Site_p.G204_splice|SLC3A1_uc002rub.2_Splice_Site_p.G204_splice	NM_000341	NP_000332	Q07837	SLC31_HUMAN	solute carrier family 3, member 1						carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity				0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	TTACTCATTAGGTTTAAAATT	0.249000													29	32					0	0	0.034045	0	0
FSHR	2492	broad.mit.edu	37	2	49190328	49190328	+	Silent	SNP	G	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr2:49190328G>A	uc002rww.2	-	10	1706	c.1632C>T	c.(1630-1632)GTC>GTT	p.V544V	FSHR_uc002rwx.2_Silent_p.V482V|FSHR_uc010fbn.2_Silent_p.V518V	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	544	Helical; Name=5; (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	AGCCACAGATGACCACAAAGG	0.532000									Gonadal_Dysgenesis_46_XX				16	18					0	0	0.033300	0	0
MRPS5	64969	broad.mit.edu	37	2	95753148	95753148	+	Missense_Mutation	SNP	C	G	G			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr2:95753148C>G	uc002sub.2	-	12	1465	c.1247G>C	c.(1246-1248)GGA>GCA	p.G416A	MRPS5_uc002suc.2_RNA	NM_031902	NP_114108	P82675	RT05_HUMAN	mitochondrial ribosomal protein S5	416					translation	mitochondrion|ribosome	protein binding|RNA binding|structural constituent of ribosome			ovary(2)|central_nervous_system(1)	3						GCGCTTCATTCCCTGTGCAGT	0.572000													35	41					0	0	0.054565	0	0
IL1RL2	8808	broad.mit.edu	37	2	102836361	102836361	+	Missense_Mutation	SNP	A	C	C			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr2:102836361A>C	uc002tbs.2	+	8	1001	c.875A>C	c.(874-876)GAA>GCA	p.E292A	IL1RL2_uc002tbt.2_Missense_Mutation_p.E174A	NM_003854	NP_003845	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2 precursor	292	Extracellular (Potential).|Ig-like C2-type 3.				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			ovary(2)	2						TCTTTTCGGGAACATAATTTG	0.358000													34	50					0	0	0.059317	0	0
WNT10A	80326	broad.mit.edu	37	2	219754716	219754716	+	Missense_Mutation	SNP	G	C	C			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr2:219754716G>C	uc002vjd.1	+	3	850	c.387G>C	c.(385-387)GAG>GAC	p.E129D		NM_025216	NP_079492	Q9GZT5	WN10A_HUMAN	wingless-type MMTV integration site family,	129					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|female gonad development|hair follicle morphogenesis|odontogenesis|regulation of odontogenesis of dentine-containing tooth|sebaceous gland development|skin development|tongue development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			lung(1)|skin(1)	2		Renal(207;0.0474)		Epithelial(149;4.26e-07)|all cancers(144;8.8e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTTTCCGAGAGAGCGCTTTTG	0.418000													36	55					0	0	0.098360	0	0
PLK1S1	55857	broad.mit.edu	37	20	21142793	21142793	+	Silent	SNP	T	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr20:21142793T>A	uc002wsb.2	+	5	820	c.687T>A	c.(685-687)TCT>TCA	p.S229S	PLK1S1_uc010zsh.1_Silent_p.S126S|PLK1S1_uc010zsi.1_Silent_p.S96S|PLK1S1_uc010zsj.1_RNA|uc002wsc.2_Intron|PLK1S1_uc002wsd.2_RNA	NM_018474	NP_060944	Q2M2Z5	KIZ_HUMAN	polo-like kinase 1 substrate 1 isoform 1	229					spindle organization	centrosome	protein kinase binding				0						GAAAGGCATCTCTTCAGATTG	0.433000													131	38					0	0	0.048971	0	0
NCOA3	8202	broad.mit.edu	37	20	46279830	46279830	+	Silent	SNP	G	A	A	rs147918555		TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr20:46279830G>A	uc002xtk.2	+	20	3961	c.3756G>A	c.(3754-3756)CAG>CAA	p.Q1252Q	NCOA3_uc010ght.1_Silent_p.Q1243Q|NCOA3_uc002xtl.2_Silent_p.Q1248Q|NCOA3_uc002xtm.2_Silent_p.Q1247Q|NCOA3_uc002xtn.2_Silent_p.Q1251Q|NCOA3_uc010zyc.1_Silent_p.Q1047Q	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	1252	Poly-Gln.|Acetyltransferase.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						agcagcagcagcagcaacagc	0.289000													6	64					0	0	0.021553	0	0
NCAM2	4685	broad.mit.edu	37	21	22656582	22656582	+	Missense_Mutation	SNP	G	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr21:22656582G>T	uc002yld.1	+	3	448	c.199G>T	c.(199-201)GTA>TTA	p.V67L	NCAM2_uc011acb.1_Intron|NCAM2_uc011acc.1_Missense_Mutation_p.V92L	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	67	Ig-like C2-type 1.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		AACACAGAGGGTAGTAGTGCA	0.398000													22	40					6.44725e-10	7.21812e-10	0.069288	1	0
KRTAP13-3	337960	broad.mit.edu	37	21	31797740	31797740	+	Missense_Mutation	SNP	T	C	C			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr21:31797740T>C	uc002yob.1	-	1	491	c.491A>G	c.(490-492)CAG>CGG	p.Q164R		NM_181622	NP_853653	Q3SY46	KR133_HUMAN	keratin associated protein 13-3	164						intermediate filament				ovary(1)|lung(1)	2						ACAGAATGGCTGATAACAAGA	0.378000													3	51					0	0	0.004672	0	0
TTC3	7267	broad.mit.edu	37	21	38536463	38536463	+	Missense_Mutation	SNP	G	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr21:38536463G>A	uc002yvz.2	+	32	3386	c.3281G>A	c.(3280-3282)CGC>CAC	p.R1094H	TTC3_uc011aee.1_Missense_Mutation_p.R784H|TTC3_uc002ywa.2_Missense_Mutation_p.R1094H|TTC3_uc002ywb.2_Missense_Mutation_p.R1094H|TTC3_uc010gnf.2_Missense_Mutation_p.R859H|TTC3_uc002ywc.2_Missense_Mutation_p.R784H|TTC3_uc002ywd.1_Missense_Mutation_p.R158H	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1094					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				TATGTTGTCCGCAATAAGAAG	0.393000													4	89					0	0	0.009096	0	0
BCL2L13	23786	broad.mit.edu	37	22	18138590	18138590	+	Missense_Mutation	SNP	C	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr22:18138590C>T	uc002zmw.2	+	2	331	c.113C>T	c.(112-114)TCA>TTA	p.S38L	BCL2L13_uc002zmu.2_Missense_Mutation_p.S38L|BCL2L13_uc002zmv.2_Missense_Mutation_p.S38L|BCL2L13_uc002zmx.2_5'UTR|BCL2L13_uc002zmy.2_Missense_Mutation_p.S38L|BCL2L13_uc010gqy.2_5'UTR|BCL2L13_uc011agk.1_Missense_Mutation_p.H26Y|BCL2L13_uc010gqz.2_5'UTR	NM_015367	NP_056182	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	38					induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4		all_epithelial(15;0.123)		Lung(27;0.199)		CATCTTTCCTCACCCCAAGGT	0.358000													28	0					0	0	0.037714	0	0
NR1D2	9975	broad.mit.edu	37	3	24003534	24003534	+	Missense_Mutation	SNP	T	G	G			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr3:24003534T>G	uc003ccs.2	+	5	903	c.584T>G	c.(583-585)ATG>AGG	p.M195R	NR1D2_uc010hfd.2_RNA|NR1D2_uc011awk.1_Missense_Mutation_p.M120R	NM_005126	NP_005117	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	195					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			urinary_tract(1)|kidney(1)|skin(1)	3						CAAAGTGCAATGAAGACCATG	0.413000													19	30					0	0	0.062417	0	0
SCN11A	11280	broad.mit.edu	37	3	38889146	38889146	+	Missense_Mutation	SNP	C	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr3:38889146C>T	uc011ays.1	-	26	4614	c.4415G>A	c.(4414-4416)CGA>CAA	p.R1472Q		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1472	IV.|Helical; Voltage-sensor; Name=S4 of repeat IV; (By similarity).				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CCTCAGGATTCGGCCAATCCG	0.498000													3	24					0	0	0.009096	0	0
TGM4	7047	broad.mit.edu	37	3	44935102	44935102	+	Missense_Mutation	SNP	G	A	A	rs147559877		TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr3:44935102G>A	uc003coc.3	+	5	537	c.464G>A	c.(463-465)CGC>CAC	p.R155H	TGM4_uc003cob.2_RNA	NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	155					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	GAGGACGAGCGCAAAGAGTAC	0.507000													30	43					0	0	0.037714	0	0
LZTFL1	54585	broad.mit.edu	37	3	45874547	45874547	+	Missense_Mutation	SNP	T	G	G			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr3:45874547T>G	uc003cox.1	-	5	589	c.451A>C	c.(451-453)AAC>CAC	p.N151H	LZTFL1_uc003coy.1_Missense_Mutation_p.N134H|LZTFL1_uc011bak.1_RNA	NM_020347	NP_065080	Q9NQ48	LZTL1_HUMAN	leucine zipper transcription factor-like 1	151	Potential.										0				BRCA - Breast invasive adenocarcinoma(193;0.00867)|KIRC - Kidney renal clear cell carcinoma(197;0.0177)|Kidney(197;0.0208)		ATTACCTTGTTTAGGAGTTCT	0.393000													31	55					0	0	0.041601	0	0
USP4	7375	broad.mit.edu	37	3	49362339	49362339	+	Silent	SNP	T	C	C			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr3:49362339T>C	uc003cwq.2	-	5	700	c.621A>G	c.(619-621)CTA>CTG	p.L207L	USP4_uc003cwr.2_Silent_p.L207L	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	207					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		GACCCTGGTATAGCCCAGCAT	0.547000													79	94					0	0	0.048971	0	0
CNTN3	5067	broad.mit.edu	37	3	74350871	74350871	+	Missense_Mutation	SNP	G	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr3:74350871G>T	uc003dpm.1	-	14	1952	c.1872C>A	c.(1870-1872)AAC>AAA	p.N624K		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	624	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		CTGGGCTATGGTTGTCTTTAC	0.468000													42	51					6.2361e-21	7.46882e-21	0.098360	1	0
PIK3CB	5291	broad.mit.edu	37	3	138456588	138456588	+	Silent	SNP	T	C	C			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr3:138456588T>C	uc011bmq.1	-	4	762	c.762A>G	c.(760-762)GTA>GTG	p.V254V		NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	254	PI3K-RBD.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						AAACATATTCTACTCTCCCGC	0.318000													46	38					0	0	0.048971	0	0
PARL	55486	broad.mit.edu	37	3	183551347	183551348	+	Missense_Mutation	DNP	CT	GG	GG			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr3:183551347_183551348CT>GG	uc003fmd.2	-	9	1019_1020	c.960_961AG>CC	c.(958-963)ACAGCA>ACCCCA	p.A321P	PARL_uc003fme.2_Missense_Mutation_p.A271P	NM_018622	NP_061092	Q9H300	PARL_HUMAN	presenilin associated, rhomboid-like isoform 1	321	Mitochondrial matrix (Potential).				proteolysis	integral to membrane|mitochondrial inner membrane|nucleus	serine-type endopeptidase activity				0	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.21e-41)|Epithelial(37;1.34e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			ATCATTCCTGCTGTATCCATGG	0.446000													33	49					0	0	0.004672	0	0
RNF168	165918	broad.mit.edu	37	3	196214405	196214405	+	Silent	SNP	G	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr3:196214405G>T	uc003fwq.2	-	3	961	c.423C>A	c.(421-423)GCC>GCA	p.A141A	RNF168_uc010iah.2_5'UTR	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	141	Glu-rich.				double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		ATTCTTCACTGGCTTTGTTTT	0.443000													97	101					2.77303e-49	3.44123e-49	0.048971	1	0
LOC650293	650293	broad.mit.edu	37	4	8951612	8951612	+	Missense_Mutation	SNP	C	G	G			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr4:8951612C>G	uc011bwm.1	+	1	136	c.136C>G	c.(136-138)CCC>GCC	p.P46A		NM_001040071	NP_001035160	Q8NGT4	Q8NGT4_HUMAN	seven transmembrane helix receptor	46						integral to membrane	olfactory receptor activity				0						GGCCATGGTTCCCAAGATGAT	0.522000													6	5					0	0	0.038147	0	0
YTHDC1	91746	broad.mit.edu	37	4	69203291	69203291	+	Missense_Mutation	SNP	T	G	G			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr4:69203291T>G	uc003hdx.2	-	3	811	c.458A>C	c.(457-459)GAG>GCG	p.E153A	YTHDC1_uc003hdy.2_Missense_Mutation_p.E153A	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	153										upper_aerodigestive_tract(1)|ovary(1)	2						ATTTACTACCTCAGAACCATC	0.403000													32	29					0	0	0.054565	0	0
ENAM	10117	broad.mit.edu	37	4	71510231	71510231	+	Missense_Mutation	SNP	C	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr4:71510231C>T	uc011caw.1	+	9	3369	c.3088C>T	c.(3088-3090)CCA>TCA	p.P1030S		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	1030					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			AGGCTCCAATCCAGAAGGCAT	0.433000													59	60					0	0	0.048971	0	0
ANXA3	306	broad.mit.edu	37	4	79512751	79512751	+	Missense_Mutation	SNP	C	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr4:79512751C>T	uc003hld.2	+	7	767	c.457C>T	c.(457-459)CGG>TGG	p.R153W	ANXA3_uc003hle.2_Missense_Mutation_p.R114W|ANXA3_uc010ijk.2_Missense_Mutation_p.R114W	NM_005139	NP_005130	P12429	ANXA3_HUMAN	annexin A3	153	Annexin 2.				defense response to bacterium|neutrophil degranulation|phagocytosis|positive regulation of angiogenesis|positive regulation of endothelial cell migration|positive regulation of sequence-specific DNA binding transcription factor activity	phagocytic vesicle membrane|plasma membrane|specific granule	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity				0						TGGTGACTTCCGGAAAGCTCT	0.343000													95	131					0	0	0.048971	0	0
MTRR	4552	broad.mit.edu	37	5	7873543	7873543	+	Missense_Mutation	SNP	G	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr5:7873543G>A	uc003jed.2	+	3	298	c.268G>A	c.(268-270)GGA>AGA	p.G90R	MTRR_uc010itn.1_Intron|MTRR_uc003jee.3_Missense_Mutation_p.G63R|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_Intron|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	90	Flavodoxin-like.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	CACGGGCACCGGAGACCCACC	0.478000													68	179					0	0	0.048971	0	0
TRIO	7204	broad.mit.edu	37	5	14471560	14471560	+	Missense_Mutation	SNP	C	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr5:14471560C>T	uc003jff.2	+	38	5903	c.5897C>T	c.(5896-5898)TCT>TTT	p.S1966F	TRIO_uc003jfg.2_RNA|TRIO_uc003jfh.1_Missense_Mutation_p.S1615F	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1966					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					AAATCCAGCTCTTTAAAGAGA	0.438000													75	27					0	0	0.048971	0	0
RICTOR	253260	broad.mit.edu	37	5	38954924	38954924	+	Nonsense_Mutation	SNP	A	C	C			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr5:38954924A>C	uc003jlp.2	-	27	2673	c.2649T>G	c.(2647-2649)TAT>TAG	p.Y883*	RICTOR_uc003jlo.2_Nonsense_Mutation_p.Y883*|RICTOR_uc010ivf.2_Nonsense_Mutation_p.Y598*	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	883					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					CTAGTTGTCCATAAAGGTGTA	0.313000													123	73					0	0	0.048971	0	0
PIK3R1	5295	broad.mit.edu	37	5	67588178	67588178	+	Silent	SNP	A	G	G			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr5:67588178A>G	uc003jva.2	+	8	1568	c.1008A>G	c.(1006-1008)GGA>GGG	p.G336G	PIK3R1_uc003jvb.2_Silent_p.G336G|PIK3R1_uc003jvc.2_Silent_p.G36G|PIK3R1_uc003jvd.2_Silent_p.G66G|PIK3R1_uc003jve.2_Silent_p.G15G|PIK3R1_uc011crb.1_5'Flank	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	336	SH2 1.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	GGTACTGGGGAGATATCTCGA	0.393000			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			64	133					0	0	0.048971	0	0
PIK3R1	5295	broad.mit.edu	37	5	67591286	67591286	+	Missense_Mutation	SNP	A	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr5:67591286A>T	uc003jva.2	+	14	2344	c.1784A>T	c.(1783-1785)AAC>ATC	p.N595I	PIK3R1_uc003jvb.2_Missense_Mutation_p.N595I|PIK3R1_uc003jvc.2_Missense_Mutation_p.N295I|PIK3R1_uc003jvd.2_Missense_Mutation_p.N325I|PIK3R1_uc003jve.2_Missense_Mutation_p.N274I|PIK3R1_uc011crb.1_Missense_Mutation_p.N265I	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	595					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.M582_D605>I(4)|p.Y580fs*1(1)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	AAGAAGTTGAACGAGTGGTTG	0.368000			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			33	69					0	0	0.054565	0	0
ACSL6	23305	broad.mit.edu	37	5	131324510	131324510	+	Missense_Mutation	SNP	T	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr5:131324510T>A	uc010jdo.1	-	6	648	c.565A>T	c.(565-567)ATC>TTC	p.I189F	ACSL6_uc003kvv.1_RNA|ACSL6_uc003kvx.1_Missense_Mutation_p.I214F|ACSL6_uc003kvy.1_Missense_Mutation_p.I214F|ACSL6_uc003kwb.2_Missense_Mutation_p.I179F|ACSL6_uc003kvz.1_Missense_Mutation_p.I154F|ACSL6_uc003kwa.1_Missense_Mutation_p.I200F|ACSL6_uc010jdn.1_Missense_Mutation_p.I189F|ACSL6_uc010jdp.1_5'Flank	NM_015256	NP_056071	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	189	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTATTGATGATGTAGCGGATA	0.572000													83	161					0	0	0.048971	0	0
ATP10B	23120	broad.mit.edu	37	5	160113261	160113262	+	Missense_Mutation	DNP	GG	TC	TC			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr5:160113261_160113262GG>TC	uc003lym.1	-	6	1141_1142	c.294_295CC>GA	c.(292-297)TTCCTG>TTGATG	p.98_99FL>LM	ATP10B_uc003lyp.2_Missense_Mutation_p.98_99FL>LM|ATP10B_uc011deg.1_Missense_Mutation_p.142_143FL>LM|ATP10B_uc003lyo.2_5'Flank	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	98_99	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACCAGGAACAGGAAATAGAGGT	0.450000													10	37					0	0	0.004672	0	0
BTNL8	79908	broad.mit.edu	37	5	180374575	180374575	+	Missense_Mutation	SNP	G	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr5:180374575G>A	uc003mmp.2	+	4	971	c.737G>A	c.(736-738)GGC>GAC	p.G246D	BTNL8_uc003mmq.2_Missense_Mutation_p.G246D|BTNL8_uc011dhg.1_Missense_Mutation_p.G121D|BTNL8_uc010jll.2_Missense_Mutation_p.G246D|BTNL8_uc010jlm.2_Missense_Mutation_p.G130D|BTNL8_uc011dhh.1_Missense_Mutation_p.G62D	NM_001040462	NP_001035552	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8 isoform 2 precursor	246	Helical; (Potential).					integral to membrane				upper_aerodigestive_tract(1)|skin(1)	2	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTCTGCTGTGGCCTATTTTTT	0.443000													428	233					0	0	0.048971	0	0
MTCH1	23787	broad.mit.edu	37	6	36949411	36949411	+	Missense_Mutation	SNP	T	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr6:36949411T>A	uc003ond.1	-	2	359	c.359A>T	c.(358-360)AAT>ATT	p.N120I	MTCH1_uc003onc.1_Missense_Mutation_p.N120I|MTCH1_uc010jwo.1_RNA|MTCH1_uc003one.3_Missense_Mutation_p.N120I|MTCH1_uc011dtt.1_Intron	NM_014341	NP_055156	Q9NZJ7	MTCH1_HUMAN	mitochondrial carrier homolog 1	120	Solcar 1.				activation of caspase activity|neuronal ion channel clustering|positive regulation of apoptosis|regulation of signal transduction|transport	integral to membrane|mitochondrial inner membrane	protein binding				0						CCCCAGCACATTGGTCCCAAG	0.562000													18	0					0	0	0.038395	0	0
TBL2	26608	broad.mit.edu	37	7	72985195	72985195	+	Missense_Mutation	SNP	G	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr7:72985195G>T	uc003tyh.2	-	7	1120	c.986C>A	c.(985-987)GCG>GAG	p.A329E	TBL2_uc011kex.1_Missense_Mutation_p.A293E|TBL2_uc010lbg.2_Missense_Mutation_p.A234E|TBL2_uc003tyi.2_Missense_Mutation_p.A164E|TBL2_uc011key.1_Missense_Mutation_p.A200E|TBL2_uc010lbh.2_Missense_Mutation_p.A234E	NM_012453	NP_036585	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	329	WD 6.										0		Lung NSC(55;0.0659)|all_lung(88;0.152)				GGCACCCGCCGCCTCTTCAAA	0.597000													7	101					8.12818e-05	8.72086e-05	0.029380	1	0
C7orf43	55262	broad.mit.edu	37	7	99753405	99753405	+	Silent	SNP	G	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr7:99753405G>A	uc003utr.2	-	9	1464	c.1284C>T	c.(1282-1284)GCC>GCT	p.A428A	C7orf43_uc010lgo.2_Silent_p.A54A|C7orf43_uc010lgp.2_Silent_p.A50A|C7orf43_uc011kjj.1_Silent_p.A196A|C7orf43_uc003uts.2_Silent_p.A159A	NM_018275	NP_060745	Q8WVR3	CG043_HUMAN	hypothetical protein LOC55262	428											0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CGGAGTCCAGGGCAGCCTGCA	0.637000													44	42					0	0	0.042209	0	0
LRRN3	54674	broad.mit.edu	37	7	110763780	110763780	+	Missense_Mutation	SNP	A	G	G			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr7:110763780A>G	uc003vft.3	+	4	1998	c.952A>G	c.(952-954)AAC>GAC	p.N318D	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Missense_Mutation_p.N318D|LRRN3_uc003vfs.3_Missense_Mutation_p.N318D	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	318	Extracellular (Potential).|LRR 11.					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		AGAAGCTACTAACAACCCTAG	0.418000													53	43					0	0	0.048971	0	0
TNPO3	23534	broad.mit.edu	37	7	128626935	128626935	+	Missense_Mutation	SNP	T	A	A			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr7:128626935T>A	uc003vol.1	-	12	1912	c.1538A>T	c.(1537-1539)AAG>ATG	p.K513M	TNPO3_uc010llx.1_5'Flank|TNPO3_uc003vom.1_Missense_Mutation_p.K447M|TNPO3_uc010lly.1_Missense_Mutation_p.K547M|TNPO3_uc010llz.1_Intron	NM_012470	NP_036602	Q9Y5L0	TNPO3_HUMAN	transportin 3	513					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			ovary(2)|skin(2)|lung(1)	5						AGCCAGGGGCTTTTCACACAG	0.453000													63	45					0	0	0.048971	0	0
C8orf76	84933	broad.mit.edu	37	8	124243792	124243792	+	Missense_Mutation	SNP	G	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr8:124243792G>T	uc003yqc.1	-	4	594	c.563C>A	c.(562-564)TCT>TAT	p.S188Y	C8orf76_uc003yqd.2_Missense_Mutation_p.S156Y	NM_032847	NP_116236	Q96K31	CH076_HUMAN	hypothetical protein LOC84933	188							binding			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			CTGTTTCTGAGATGACGCAAG	0.438000													6	172					0.00116845	0.00124072	0.021553	1	0
PLEC	5339	broad.mit.edu	37	8	144995793	144995793	+	Silent	SNP	C	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr8:144995793C>T	uc003zaf.1	-	32	8777	c.8607G>A	c.(8605-8607)GCG>GCA	p.A2869A	PLEC_uc003zab.1_Silent_p.A2732A|PLEC_uc003zac.1_Silent_p.A2736A|PLEC_uc003zad.2_Silent_p.A2732A|PLEC_uc003zae.1_Silent_p.A2700A|PLEC_uc003zag.1_Silent_p.A2710A|PLEC_uc003zah.2_Silent_p.A2718A|PLEC_uc003zaj.2_Silent_p.A2759A	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2869	Globular 2.|Plectin 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						AGGCCGCCTGCGCCTCCAGCA	0.667000													3	42					0	0	0.004672	0	0
WASH5P	375690	broad.mit.edu	37	9	17011	17011	+	Silent	SNP	T	C	C			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr9:17011T>C	uc010mgm.1	-	7	980	c.837A>G	c.(835-837)CCA>CCG	p.P279P	WASH5P_uc003zfr.2_RNA|WASH5P_uc011llq.1_RNA|WASH5P_uc003zfu.1_Silent_p.P292P	NM_182905	NP_878908			WAS protein family homolog 1												0						TGGGCAGTTCTGGAATGGTGC	0.642000													3	14					0	0	0.029380	0	0
GBA2	57704	broad.mit.edu	37	9	35739010	35739010	+	Missense_Mutation	SNP	A	G	G			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr9:35739010A>G	uc003zxw.2	-	11	2308	c.1784T>C	c.(1783-1785)ATT>ACT	p.I595T	GBA2_uc003zxx.1_5'Flank|GBA2_uc011lpb.1_Missense_Mutation_p.I595T|GBA2_uc011lpc.1_Missense_Mutation_p.I595T|GBA2_uc011lpd.1_Missense_Mutation_p.I601T|GBA2_uc003zxy.1_Missense_Mutation_p.I308T	NM_020944	NP_065995	Q9HCG7	GBA2_HUMAN	bile acid beta-glucosidase	595	Extracellular (Potential).				bile acid metabolic process|glucosylceramide catabolic process|O-glycoside catabolic process	integral to membrane|microsome|plasma membrane|smooth endoplasmic reticulum	beta-glucosidase activity|glucosylceramidase activity			ovary(3)|skin(1)	4	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TGGGTCCCCAATATCATGGGG	0.572000													16	14					0	0	0.033300	0	0
ZNF169	169841	broad.mit.edu	37	9	97063238	97063238	+	Silent	SNP	C	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr9:97063238C>T	uc004aum.1	+	5	1503	c.1398C>T	c.(1396-1398)GGC>GGT	p.G466G		NM_194320	NP_919301	Q14929	ZN169_HUMAN	zinc finger protein 169	466	C2H2-type 9.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.136)				GTGGGCGTGGCTTTGGTCAGA	0.577000													37	34					0	0	0.064281	0	0
C9orf84	158401	broad.mit.edu	37	9	114503767	114503767	+	Missense_Mutation	SNP	A	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr9:114503767A>T	uc004bfr.2	-	9	1106	c.971T>A	c.(970-972)TTT>TAT	p.F324Y	C9orf84_uc011lwt.1_RNA|C9orf84_uc004bfs.1_Missense_Mutation_p.F388Y|C9orf84_uc004bfq.2_Missense_Mutation_p.F285Y|C9orf84_uc010mug.2_Missense_Mutation_p.F270Y	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	324										ovary(2)	2						TGTAAGCAAAAATGGGTTCAA	0.323000													43	38					0	0	0.045515	0	0
GSN	2934	broad.mit.edu	37	9	124074615	124074615	+	Splice_Site	SNP	A	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr9:124074615A>T	uc004blf.1	+	5	728	c.667_splice	c.e5-2	p.N223_splice	GSN_uc004bld.1_Splice_Site_p.N172_splice|GSN_uc010mvq.1_Splice_Site_p.N183_splice|GSN_uc010mvr.1_Splice_Site_p.N183_splice|GSN_uc010mvu.1_Splice_Site_p.N172_splice|GSN_uc010mvt.1_Splice_Site_p.N172_splice|GSN_uc010mvs.1_Splice_Site_p.N172_splice|GSN_uc004ble.1_Splice_Site_p.N172_splice|GSN_uc010mvv.1_Splice_Site_p.N172_splice|GSN_uc011lyh.1_Splice_Site_p.N189_splice|GSN_uc011lyi.1_Splice_Site_p.N172_splice|GSN_uc011lyj.1_Splice_Site_p.N196_splice|GSN_uc004blg.1_5'UTR	NM_000177	NP_000168	P06396	GELS_HUMAN	gelsolin isoform a precursor						actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			breast(2)|ovary(1)	3						TCTGTCTTCCAGAACATCCAC	0.612000													7	121					0	0	0.047766	0	0
TUBB2C	10383	broad.mit.edu	37	9	140137389	140137389	+	Missense_Mutation	SNP	T	C	C			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr9:140137389T>C	uc004cmh.1	+	4	821	c.719T>C	c.(718-720)CTG>CCG	p.L240P	TUBB2C_uc004cmg.1_Missense_Mutation_p.L94P	NM_006088	NP_006079	P68371	TBB2C_HUMAN	tubulin, beta, 2	240					'de novo' posttranslational protein folding|cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding|structural molecule activity|unfolded protein binding			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		ACCACCTGCCTGCGCTTCCCA	0.592000													21	19					0	0	0.055883	0	0
ODZ1	10178	broad.mit.edu	37	X	123519705	123519705	+	Silent	SNP	G	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chrX:123519705G>T	uc004euj.2	-	28	5941	c.5877C>A	c.(5875-5877)ACC>ACA	p.T1959T	ODZ1_uc011muj.1_Silent_p.T1965T|ODZ1_uc010nqy.2_Silent_p.T1966T	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1959	YD 11.|Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CCAGATGCAGGGTCTGTAGCA	0.488000													19	89					8.34094e-07	9.04333e-07	0.049695	1	0
ZDHHC9	51114	broad.mit.edu	37	X	128963040	128963040	+	Missense_Mutation	SNP	G	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chrX:128963040G>T	uc004euv.2	-	3	614	c.245C>A	c.(244-246)ACA>AAA	p.T82K	ZDHHC9_uc004euw.2_Missense_Mutation_p.T82K|ZDHHC9_uc004eux.1_Missense_Mutation_p.T82K|ZDHHC9_uc004euy.1_Missense_Mutation_p.T9K	NM_001008222	NP_001008223	Q9Y397	ZDHC9_HUMAN	zinc finger, DHHC domain containing 9	82	Helical; (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)	1						CCTCAACAGTGTAGCCATGGA	0.522000													67	2					4.38816e-42	5.31742e-42	0.048971	1	0
RLF	6018	broad.mit.edu	37	1	40705390	40705391	+	Frame_Shift_Ins	INS	-	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr1:40705390_40705391insT	uc001cfc.3	+	8	5047_5048	c.5016_5017insT	c.(5014-5019)TTGAAAfs	p.L1672fs	RLF_uc001cfd.3_Frame_Shift_Ins_p.L1363fs	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	1672_1673					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			GGGGAACTTTGAAATGTAATCA	0.411													54	51	---	---	---	---					
INCENP	3619	broad.mit.edu	37	11	61916013	61916015	+	In_Frame_Del	DEL	AGA	-	-	rs79863590		TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr11:61916013_61916015delAGA	uc001nsw.1	+	16	2472_2474	c.2270_2272delAGA	c.(2269-2274)GAGAAG>GAG	p.K761del	INCENP_uc009ynw.1_In_Frame_Del_p.K765del|INCENP_uc001nsx.1_In_Frame_Del_p.K757del|INCENP_uc001nsy.1_In_Frame_Del_p.K175del	NM_001040694	NP_001035784	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa	761	Potential.				chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			lung(1)	1						GAACTGGAGGAGAAGAAGAAGAA	0.631													7	8	---	---	---	---					
ZC3H13	23091	broad.mit.edu	37	13	46543501	46543502	+	Frame_Shift_Ins	INS	-	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr13:46543501_46543502insT	uc010tfw.1	-	13	3183_3184	c.3177_3178insA	c.(3175-3180)AAAGAAfs	p.K1059fs	ZC3H13_uc001vaq.2_5'Flank|ZC3H13_uc001vas.1_Frame_Shift_Ins_p.K1059fs|ZC3H13_uc001vat.1_Frame_Shift_Ins_p.K1059fs	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	1059_1060							nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		GCTGTATCTTCTTTTTTCTGGG	0.475													22	186	---	---	---	---					
MBIP	51562	broad.mit.edu	37	14	36770005	36770006	+	Frame_Shift_Ins	INS	-	T	T			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr14:36770005_36770006insT	uc001wtm.2	-	8	1000_1001	c.912_913insA	c.(910-915)AAAGTTfs	p.K304fs	MBIP_uc001wto.2_Frame_Shift_Ins_p.K304fs|MBIP_uc010tpy.1_Frame_Shift_Ins_p.K163fs|MBIP_uc001wtn.2_Frame_Shift_Ins_p.S272fs	NM_016586	NP_057670	Q9NS73	MBIP1_HUMAN	MAP3K12 binding inhibitory protein 1 isoform 1	304_305	Interaction with MAP3K12.				histone H3 acetylation|inactivation of MAPK activity involved in osmosensory signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|nucleolus	identical protein binding|protein kinase inhibitor activity				0	all_cancers(3;1.55e-52)|all_epithelial(1;2.69e-62)|Breast(36;0.0505)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)		Lung(8;1.28e-07)|LUAD - Lung adenocarcinoma(9;3e-07)|Epithelial(34;0.0303)|all cancers(34;0.0781)	GBM - Glioblastoma multiforme(112;0.0191)		GGTGGTTGAACTTTTCTTCTTT	0.243													11	10	---	---	---	---					
CNTNAP4	85445	broad.mit.edu	37	16	76587277	76587278	+	Frame_Shift_Ins	INS	-	GC	GC			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr16:76587277_76587278insGC	uc002feu.1	+	24	3925_3926	c.3540_3541insGC	c.(3538-3543)AAGGCAfs	p.K1180fs	CNTNAP4_uc002fev.1_Frame_Shift_Ins_p.K1044fs|CNTNAP4_uc010chb.1_Frame_Shift_Ins_p.K1107fs|CNTNAP4_uc002fex.1_Frame_Shift_Ins_p.K1183fs	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	1180_1181	Extracellular (Potential).|Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						CCCCTCTGAAGGCAGCTCTGCA	0.604													25	18	---	---	---	---					
DHX57	90957	broad.mit.edu	37	2	39030017	39030017	+	Frame_Shift_Del	DEL	T	-	-			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr2:39030017delT	uc002rrf.2	-	23	3956	c.3857delA	c.(3856-3858)AAGfs	p.K1286fs	DHX57_uc002rrd.3_Frame_Shift_Del_p.K625fs|DHX57_uc002rre.2_Frame_Shift_Del_p.K719fs	NM_198963	NP_945314	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	1286							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		all_hematologic(82;0.248)				AGTTTTTATCTTCTCGTGGTA	0.468													83	113	---	---	---	---					
CASP10	843	broad.mit.edu	37	2	202073930	202073931	+	Frame_Shift_Del	DEL	TG	-	-			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr2:202073930_202073931delTG	uc002uxl.1	+	9	1478_1479	c.1060_1061delTG	c.(1060-1062)TGTfs	p.C354fs	CASP10_uc002uxj.1_Frame_Shift_Del_p.C354fs|CASP10_uc002uxk.1_Frame_Shift_Del_p.C311fs|CASP10_uc010fta.1_Frame_Shift_Del_p.C287fs|CASP10_uc002uxm.1_Frame_Shift_Del_p.C311fs|CASP10_uc010ftb.1_RNA	NM_032974	NP_116756	Q92851	CASPA_HUMAN	caspase 10 isoform b preproprotein	354					apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			skin(3)|ovary(1)|pancreas(1)|breast(1)	6						CTTCGTGTTCTGTATTCTGACC	0.515													90	97	---	---	---	---					
SLC23A2	9962	broad.mit.edu	37	20	4850569	4850569	+	Frame_Shift_Del	DEL	G	-	-	rs138961929		TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr20:4850569delG	uc002wlg.1	-	12	1608	c.1233delC	c.(1231-1233)CCCfs	p.P411fs	SLC23A2_uc010zqr.1_Frame_Shift_Del_p.P296fs|SLC23A2_uc002wlh.1_Frame_Shift_Del_p.P411fs|SLC23A2_uc002wli.2_Frame_Shift_Del_p.P410fs	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	411					L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						TTGCGTGGATGGGGGGGGGTG	0.527													7	192	---	---	---	---					
NF2	4771	broad.mit.edu	37	22	30067890	30067905	+	Frame_Shift_Del	DEL	AGGCTGCTGCAGATGA	-	-	rs74315492		TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr22:30067890_30067905delAGGCTGCTGCAGATGA	uc003age.3	+	11	1518_1533	c.1075_1090delAGGCTGCTGCAGATGA	c.(1075-1092)AGGCTGCTGCAGATGAAAfs	p.R359fs	NF2_uc003afy.3_Frame_Shift_Del_p.R359fs|NF2_uc003afz.3_Frame_Shift_Del_p.R276fs|NF2_uc003agf.3_Frame_Shift_Del_p.R359fs|NF2_uc003agb.3_Frame_Shift_Del_p.R282fs|NF2_uc003agc.3_Frame_Shift_Del_p.R321fs|NF2_uc003agd.3_Intron|NF2_uc003agg.3_Frame_Shift_Del_p.R359fs|NF2_uc003aga.3_Frame_Shift_Del_p.R317fs|NF2_uc003agh.3_Frame_Shift_Del_p.R318fs|NF2_uc003agi.3_Frame_Shift_Del_p.R276fs|NF2_uc003agj.3_Intron|NF2_uc003agk.3_Frame_Shift_Del_p.R321fs|NF2_uc010gvp.2_Splice_Site_p.M27_splice|NF2_uc011akq.1_5'Flank	NM_000268	NP_000259	P35240	MERL_HUMAN	neurofibromin 2 isoform 1	359_364	Glu-rich.		K -> I (in melanoma).		actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.Q362*(4)|p.M363fs*12(2)|p.L361fs*6(1)|p.M334fs*4(1)|p.L361fs*3(1)|p.?(1)|p.M334_Q362del(1)|p.L127_D382del(1)|p.K364fs*5(1)		meninges(372)|soft_tissue(284)|central_nervous_system(20)|kidney(10)|pleura(9)|skin(7)|large_intestine(5)|breast(5)|urinary_tract(3)|thyroid(2)|endometrium(2)|ovary(2)|lung(2)|stomach(2)|bone(2)|pituitary(1)	728						GTTGGAGAGGAGGCTGCTGCAGATGAAAGAAGAAGC	0.565			D|Mis|N|F|S|O		meningioma|acoustic neuroma|renal 	meningioma|acoustic neuroma			Neurofibromatosis_type_2				22	16	---	---	---	---					
C5orf36	285600	broad.mit.edu	37	5	93856355	93856362	+	Frame_Shift_Del	DEL	AAATTTTT	-	-			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr5:93856355_93856362delAAATTTTT	uc011cuk.1	-	5	818_825	c.561_568delAAAAATTT	c.(559-570)CAAAAAATTTTAfs	p.Q187fs	C5orf36_uc003kkp.2_Frame_Shift_Del_p.Q187fs	NM_001145678	NP_001139150	Q8IV33	K0825_HUMAN	hypothetical protein LOC285600 isoform 1	187_190											0		all_cancers(142;2.12e-08)|all_epithelial(76;5.95e-11)|all_lung(232;0.000996)|Lung NSC(167;0.0108)|Ovarian(174;0.0218)|Colorectal(57;0.0329)|Breast(839;0.214)|Lung SC(612;0.236)		all cancers(79;3.96e-19)		TTTTTCAATAAAATTTTTTGCTGTGAAT	0.322													25	146	---	---	---	---					
MRPL22	29093	broad.mit.edu	37	5	154330411	154330411	+	Frame_Shift_Del	DEL	T	-	-			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr5:154330411delT	uc003lvy.3	+	3	146	c.108delT	c.(106-108)AGTfs	p.S36fs	MRPL22_uc003lvz.3_Intron	NM_014180	NP_054899	Q9NWU5	RM22_HUMAN	mitochondrial ribosomal protein L22 isoform a	36					translation	large ribosomal subunit|mitochondrion	structural constituent of ribosome				0	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TCCACACAAGTGCTTCTCTTG	0.398													125	61	---	---	---	---					
GBAS	2631	broad.mit.edu	37	7	56045954	56045955	+	Frame_Shift_Del	DEL	AC	-	-			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr7:56045954_56045955delAC	uc003tre.1	+	2	236_237	c.228_229delAC	c.(226-231)TTACAGfs	p.L76fs	GBAS_uc003trf.1_Frame_Shift_Del_p.L76fs	NM_001483	NP_001474	O75323	NIPS2_HUMAN	nipsnap homolog 2	76_77						integral to plasma membrane|membrane fraction|mitochondrion	protein binding			central_nervous_system(1)	1	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TATACAAATTACAGTGTGAGTG	0.361													80	70	---	---	---	---					
STMN4	81551	broad.mit.edu	37	8	27097566	27097566	+	Frame_Shift_Del	DEL	T	-	-			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr8:27097566delT	uc003xfk.2	-	5	546	c.432delA	c.(430-432)AAAfs	p.K144fs	STMN4_uc003xfj.2_Frame_Shift_Del_p.K171fs|STMN4_uc011lai.1_Frame_Shift_Del_p.K171fs|STMN4_uc011laj.1_Frame_Shift_Del_p.K135fs|STMN4_uc011lak.1_Frame_Shift_Del_p.K171fs|STMN4_uc010luo.2_Frame_Shift_Del_p.K144fs			Q9H169	STMN4_HUMAN	RecName: Full=Stathmin-4; AltName: Full=Stathmin-like protein B3;          Short=RB3;	144	Potential.				intracellular signal transduction					large_intestine(1)|pancreas(1)	2		Ovarian(32;0.00167)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0214)|Epithelial(17;9.82e-10)|Colorectal(74;0.142)		TCTGGGCCAGTTTTTCCTTAG	0.517													76	98	---	---	---	---					
AMBP	259	broad.mit.edu	37	9	116837296	116837296	+	Frame_Shift_Del	DEL	G	-	-			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr9:116837296delG	uc004bie.3	-	3	544	c.281delC	c.(280-282)ACGfs	p.T94fs	AMBP_uc011lxk.1_Frame_Shift_Del_p.T35fs|AMBP_uc010mvc.1_RNA	NM_001633	NP_001624	P02760	AMBP_HUMAN	alpha-1-microglobulin/bikunin preproprotein	94					cell adhesion|female pregnancy|heme catabolic process|interspecies interaction between organisms|negative regulation of immune response|negative regulation of JNK cascade|protein-chromophore linkage	extracellular region|plasma membrane	calcium channel inhibitor activity|calcium oxalate binding|heme binding|IgA binding|protein homodimerization activity|serine-type endopeptidase inhibitor activity|transporter activity			skin(1)	1					Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	AGCTCCAGACGTCTCCTCACA	0.453													46	53	---	---	---	---					
RABGAP1	23637	broad.mit.edu	37	9	125772734	125772738	+	Frame_Shift_Del	DEL	TTCAG	-	-			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr9:125772734_125772738delTTCAG	uc011lzh.1	+	11	1610_1614	c.1476_1480delTTCAG	c.(1474-1482)CCTTCAGTTfs	p.P492fs	RABGAP1_uc004bnl.3_RNA	NM_012197	NP_036329	Q9Y3P9	RBGP1_HUMAN	RAB GTPase activating protein 1	492_494					cell cycle	centrosome|cytosol|microtubule associated complex	Rab GTPase activator activity|tubulin binding			ovary(3)|kidney(2)	5						CAGCCAGTCCTTCAGTTCGCCTGCC	0.400													25	46	---	---	---	---					
ZER1	10444	broad.mit.edu	37	9	131515779	131515779	+	Frame_Shift_Del	DEL	A	-	-			TCGA-EV-5902-01A-11D-1589-08	TCGA-EV-5902-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	05c0e7bb-5be8-4e8d-9724-8063e99cc058	c49e0138-d7e1-4094-9d2d-b41239dea126	g.chr9:131515779delA	uc004bwa.1	-	4	843	c.410delT	c.(409-411)TTCfs	p.F137fs		NM_006336	NP_006327	Q7Z7L7	ZER1_HUMAN	zyg-11 homolog B (C. elegans)-like	137					ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			ovary(1)	1						TGTACAGCCGAAGAGGCTCAA	0.557													26	34	---	---	---	---					
