Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PER3	8863	broad.mit.edu	37	1	7845603	7845603	+	Silent	SNP	A	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr1:7845603A>C	uc001aoo.2	+	2	406	c.231A>C	c.(229-231)CTA>CTC	p.L77L	PER3_uc009vmg.1_Silent_p.L77L|PER3_uc009vmh.1_Silent_p.L77L|PER3_uc001aop.2_Silent_p.L77L|PER3_uc010nzw.1_5'UTR|PER3_uc001aon.2_Silent_p.L77L	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	77					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		CAAGCACTCTAGATGCCCTCA	0.448000													18	53					0	0	0.006122	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12855985	12855985	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr1:12855985T>C	uc001auj.1	+	4	1368	c.1265T>C	c.(1264-1266)TTG>TCG	p.L422S		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	422											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTGAATTCCTTGGTTCGTGTC	0.552000													7	151					0	0	0.001368	0	0
PTAFR	5724	broad.mit.edu	37	1	28477260	28477260	+	Silent	SNP	G	A	A	rs146920734		TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr1:28477260G>A	uc001bpl.2	-	2	400	c.273C>T	c.(271-273)AAC>AAT	p.N91N	PTAFR_uc001bpm.3_Silent_p.N91N|PTAFR_uc009vte.2_Silent_p.N91N	NM_000952	NP_000943	P25105	PTAFR_HUMAN	platelet-activating factor receptor	91	Extracellular (Potential).				chemotaxis|inflammatory response|interferon-gamma-mediated signaling pathway|phosphatidylinositol-mediated signaling	integral to plasma membrane|nucleus	phospholipid binding|platelet activating factor receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00715)|all_lung(284;0.00732)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.215)|OV - Ovarian serous cystadenocarcinoma(117;6e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|STAD - Stomach adenocarcinoma(196;0.00678)|READ - Rectum adenocarcinoma(331;0.0649)		AGCCAGCCACGTTGCACAGGA	0.522000													26	44					0	0	0.003954	0	0
MECR	51102	broad.mit.edu	37	1	29520539	29520539	+	Missense_Mutation	SNP	T	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr1:29520539T>A	uc001brq.1	-	10	1153	c.1117A>T	c.(1117-1119)ATG>TTG	p.M373L	MECR_uc001brp.1_Missense_Mutation_p.M297L|MECR_uc001brr.1_Missense_Mutation_p.M297L|MECR_uc001brs.1_RNA	NM_016011	NP_057095	Q9BV79	MECR_HUMAN	trans-2-enoyl-CoA reductase, mitochondrial	373				M -> I (in Ref. 2; CAG32984).	fatty acid biosynthetic process	mitochondrion	trans-2-enoyl-CoA reductase (NADPH) activity|zinc ion binding			ovary(1)	1		Colorectal(325;0.000389)|Breast(348;0.00765)|Lung NSC(340;0.0081)|all_lung(284;0.00914)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.39e-07)|COAD - Colon adenocarcinoma(152;2.04e-05)|STAD - Stomach adenocarcinoma(196;0.0195)|BRCA - Breast invasive adenocarcinoma(304;0.053)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.137)		GATGATCACATGGTGAGAATC	0.597000													28	59					0	0	0.008361	0	0
TXLNA	200081	broad.mit.edu	37	1	32646099	32646099	+	Silent	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr1:32646099T>C	uc001bui.2	+	2	218	c.153T>C	c.(151-153)GCT>GCC	p.A51A	TXLNA_uc001buj.2_Silent_p.A51A	NM_175852	NP_787048	P40222	TXLNA_HUMAN	taxilin	51					cell proliferation|exocytosis	cytoplasm|extracellular region	cytokine activity|high molecular weight B cell growth factor receptor binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				GCAGCCAGGCTCCTCGGAAGC	0.701000													4	10					0	0	0.000248	0	0
CDCA8	55143	broad.mit.edu	37	1	38174030	38174030	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr1:38174030C>T	uc001cbr.2	+	11	942	c.835C>T	c.(835-837)CAC>TAC	p.H279Y	CDCA8_uc001cbs.2_Missense_Mutation_p.H279Y	NM_018101	NP_060571	Q53HL2	BOREA_HUMAN	cell division cycle associated 8	279					cell division|chromosome organization|mitotic metaphase|mitotic prometaphase	chromosome passenger complex|chromosome, centromeric region|cytosol|nucleolus|spindle	protein binding			central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CATACGGACCCACAAATGAGA	0.483000													13	43					0	0	0.001855	0	0
LRRC40	55631	broad.mit.edu	37	1	70671136	70671136	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr1:70671136C>G	uc001der.1	-	1	140	c.88G>C	c.(88-90)GGG>CGG	p.G30R	SFRS11_uc009wbi.2_5'Flank|SFRS11_uc009wbj.1_5'Flank|SFRS11_uc010oqo.1_5'Flank|SFRS11_uc001des.2_5'Flank|SFRS11_uc001det.2_5'Flank	NM_017768	NP_060238	Q9H9A6	LRC40_HUMAN	leucine rich repeat containing 40	30										ovary(1)	1						TTCAACAGCCCTTGGGGTACC	0.562000													7	63					0	0	0.003080	0	0
OR6K2	81448	broad.mit.edu	37	1	158669896	158669896	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr1:158669896C>T	uc001fsu.1	-	1	547	c.547G>A	c.(547-549)GTG>ATG	p.V183M		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					AGACGCAGCACTGGGAGGAAG	0.478000													29	63					0	0	0.001786	0	0
PAPPA2	60676	broad.mit.edu	37	1	176740277	176740277	+	Missense_Mutation	SNP	G	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr1:176740277G>T	uc001gkz.2	+	17	5840	c.4676G>T	c.(4675-4677)GGG>GTG	p.G1559V	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1559	Sushi 3.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TGCAAACCAGGGTACTATGTG	0.478000													18	47					0.000566183	0.000645185	0.004990	1	0
CFHR3	10878	broad.mit.edu	37	1	196762616	196762617	+	Missense_Mutation	DNP	GA	TT	TT	rs149081467		TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr1:196762616_196762617GA>TT	uc001gtl.2	+	6	1053_1054	c.966_967GA>TT	c.(964-969)GGGATA>GGTTTA	p.I323L	CFHR3_uc010poy.1_Missense_Mutation_p.I262L|CFHR1_uc001gtm.2_Intron	NM_021023	NP_066303	Q02985	FHR3_HUMAN	complement factor H-related 3 precursor	323	Sushi 5.					extracellular space					0						GTCGGGAAGGGATAGTGGAATA	0.381000													7	90					0	0	0.004672	0	0
OLAH	55301	broad.mit.edu	37	10	15107661	15107661	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr10:15107661G>A	uc001inu.2	+	6	735	c.481G>A	c.(481-483)GGC>AGC	p.G161S	ACBD7_uc010qby.1_Intron|OLAH_uc001int.2_Missense_Mutation_p.G214S	NM_001039702	NP_001034791	Q9NV23	SAST_HUMAN	oleoyl-ACP hydrolase isoform 2	161					fatty acid biosynthetic process		myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity				0						GGAATTTGGAGGCACCCCCAA	0.408000													16	42					0	0	0.004007	0	0
SLC5A12	159963	broad.mit.edu	37	11	26725363	26725363	+	Missense_Mutation	SNP	A	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr11:26725363A>C	uc001mra.2	-	5	970	c.657T>G	c.(655-657)AAT>AAG	p.N219K	SLC5A12_uc001mrb.2_RNA|SLC5A12_uc001mrc.3_Missense_Mutation_p.N219K	NM_178498	NP_848593	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/glucose	219	Extracellular (Potential).				sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(1)|skin(1)	2						GTCGAGATCCATTTGTTGATT	0.368000													47	99					0	0	0.003610	0	0
LRFN4	78999	broad.mit.edu	37	11	66625625	66625625	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr11:66625625C>T	uc001ojr.2	+	1	750	c.410C>T	c.(409-411)CCG>CTG	p.P137L	PC_uc001ojo.1_Intron|PC_uc001ojp.1_Intron|PC_uc001ojn.1_Intron|LRFN4_uc001ojq.1_Missense_Mutation_p.P137L|LRFN4_uc001ojs.2_Missense_Mutation_p.P137L	NM_024036	NP_076941	Q6PJG9	LRFN4_HUMAN	leucine rich repeat and fibronectin type III	137	LRR 4.|Extracellular (Potential).					integral to membrane					0						CGCATCGCGCCGGGAGCCTTC	0.692000													17	41					0	0	0.004990	0	0
LRP5	4041	broad.mit.edu	37	11	68205929	68205929	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr11:68205929C>T	uc001ont.2	+	20	4202	c.4127C>T	c.(4126-4128)CCC>CTC	p.P1376L	LRP5_uc009ysg.2_Missense_Mutation_p.P786L	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	1376	Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						ACCAAGCCGCCCTCAGACGAC	0.592000													16	54					0	0	0.001523	0	0
MLL2	8085	broad.mit.edu	37	12	49433380	49433380	+	Silent	SNP	C	G	G			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr12:49433380C>G	uc001rta.3	-	32	8067	c.8067G>C	c.(8065-8067)CTG>CTC	p.L2689L		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2689	Potential.|LXXLL motif 1.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GCCGAATCAGCAGCTCTCGTA	0.577000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			6	18					0	0	0.006214	0	0
NAB2	4665	broad.mit.edu	37	12	57485457	57485457	+	Silent	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr12:57485457T>C	uc001smz.2	+	2	1011	c.633T>C	c.(631-633)CCT>CCC	p.P211P		NM_005967	NP_005958	Q15742	NAB2_HUMAN	NGFI-A binding protein 2	211					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TCTCCCCCCCTGCAGGGGGAG	0.711000													9	26					0	0	0.004007	0	0
POLR3B	55703	broad.mit.edu	37	12	106889911	106889911	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr12:106889911C>A	uc001tlp.2	+	24	3014	c.2792C>A	c.(2791-2793)CCA>CAA	p.P931Q	POLR3B_uc001tlq.2_Missense_Mutation_p.P873Q	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	931					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						ATCATGAACCCACACGGCTTC	0.488000													4	129					0.000602214	0.000678356	0.000602	1	0
RPH3A	22895	broad.mit.edu	37	12	113306301	113306301	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr12:113306301C>A	uc010syl.1	+	8	873	c.511C>A	c.(511-513)CCT>ACT	p.P171T	RPH3A_uc001ttz.2_Missense_Mutation_p.P171T|RPH3A_uc001tty.2_Missense_Mutation_p.P167T|RPH3A_uc009zwe.1_Missense_Mutation_p.P167T|RPH3A_uc010sym.1_Missense_Mutation_p.P122T|RPH3A_uc001tua.2_5'UTR	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	171	Pro-rich.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		ACAGCCTATGCCTATAAAGAA	0.602000													12	41					2.27111e-07	2.71425e-07	0.001368	1	0
CCDC62	84660	broad.mit.edu	37	12	123286278	123286278	+	Missense_Mutation	SNP	A	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr12:123286278A>T	uc001udc.2	+	9	1730	c.1585A>T	c.(1585-1587)ATG>TTG	p.M529L	CCDC62_uc010tah.1_RNA|CCDC62_uc001udf.2_Missense_Mutation_p.M529L|CCDC62_uc001ude.2_Missense_Mutation_p.M290L	NM_201435	NP_958843	Q6P9F0	CCD62_HUMAN	coiled-coil domain containing 62 isoform b	529						cytoplasm|nucleus				ovary(2)|large_intestine(1)|pancreas(1)|skin(1)	5	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.51e-06)|Epithelial(86;2.65e-05)|BRCA - Breast invasive adenocarcinoma(302;0.206)		CCCAGGCCACATGTCTGACGT	0.502000													54	171					0	0	0.003610	0	0
SLC15A4	121260	broad.mit.edu	37	12	129283926	129283926	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr12:129283926A>G	uc001uhu.2	-	7	1504	c.1451T>C	c.(1450-1452)ATG>ACG	p.M484T	SLC15A4_uc001uhv.2_RNA	NM_145648	NP_663623	Q8N697	S15A4_HUMAN	solute carrier family 15, member 4	484					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.69e-06)|Epithelial(86;1.17e-05)|all cancers(50;5.07e-05)		GGCACTCTGCATGGACTTGGG	0.512000													34	50					0	0	0.002836	0	0
SLITRK1	114798	broad.mit.edu	37	13	84453895	84453895	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr13:84453895G>A	uc001vlk.2	-	1	2634	c.1748C>T	c.(1747-1749)GCT>GTT	p.A583V		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	583	Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CGAGATCCTAGCGTACAGCTG	0.542000													8	23					0	0	0.004482	0	0
UBAC2	337867	broad.mit.edu	37	13	99890774	99890774	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr13:99890774T>C	uc001voa.3	+	2	609	c.125T>C	c.(124-126)GTG>GCG	p.V42A	UBAC2_uc010tiu.1_Missense_Mutation_p.C92R|UBAC2_uc001vob.3_Missense_Mutation_p.C92R|UBAC2_uc010tiv.1_RNA|UBAC2_uc001vod.2_5'UTR|UBAC2_uc001voc.2_Missense_Mutation_p.C84R|UBAC2_uc010tiw.1_RNA	NM_001144072	NP_001137544	Q8NBM4	UBAC2_HUMAN	UBA domain containing 2 isoform 1	42	Extracellular (Potential).					integral to membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					AAGCTCTTTGTGTATGACCTT	0.547000													64	209					0	0	0.003610	0	0
LAMP1	3916	broad.mit.edu	37	13	113960803	113960803	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr13:113960803T>C	uc001vtm.1	+	2	346	c.65T>C	c.(64-66)CTC>CCC	p.L22P	LAMP1_uc010tka.1_Missense_Mutation_p.L22P	NM_005561	NP_005552	P11279	LAMP1_HUMAN	lysosomal-associated membrane protein 1	22				LLLLLGLMHCA -> PVAAARPHALS (in Ref. 1; AAA60382).		endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				central_nervous_system(2)	2	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			TTGACAGGCCTCATGCATTGT	0.473000													3	150					0	0	0.000248	0	0
ADAM6	8755	broad.mit.edu	37	14	107062402	107062402	+	RNA	SNP	G	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr14:107062402G>C	uc010tyt.1	-	131		c.6193C>G								Parts of antibodies, mostly variable regions.												0						TCCTGGGCCCGACTCCTGCAG	0.597000													3	72					0	0	0.003080	0	0
SCAMP2	10066	broad.mit.edu	37	15	75142970	75142970	+	Missense_Mutation	SNP	A	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr15:75142970A>T	uc002azb.1	-	6	591	c.517T>A	c.(517-519)TGG>AGG	p.W173R	SCAMP2_uc002aza.1_Missense_Mutation_p.W23R|SCAMP2_uc010bkg.1_Intron	NM_005697	NP_005688	O15127	SCAM2_HUMAN	secretory carrier membrane protein 2	173	Helical; (Potential).				post-Golgi vesicle-mediated transport|protein transport	integral to membrane|nucleus|recycling endosome membrane|trans-Golgi network membrane	protein binding			ovary(1)	1						CCCGAGAACCAGGCCAGGCAG	0.562000													18	64					0	0	0.007413	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79059040	79059041	+	Missense_Mutation	DNP	AT	GC	GC	rs144043775	by1000genomes	TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr15:79059040_79059041AT>GC	uc002bej.3	-	19	3423_3424	c.3212_3213AT>GC	c.(3211-3213)AAT>AGC	p.N1071S	ADAMTS7_uc010und.1_3'UTR	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1071					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						CCTCGTGGAAATTGATGAAATT	0.619000													3	30					0	0	0.004672	0	0
ACSM2A	123876	broad.mit.edu	37	16	20482481	20482481	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr16:20482481C>G	uc010bwe.2	+	6	922	c.683C>G	c.(682-684)CCC>CGC	p.P228R	ACSM2A_uc010bwd.1_Intron|ACSM2A_uc010vax.1_Missense_Mutation_p.P149R|ACSM2A_uc002dhf.3_Missense_Mutation_p.P228R|ACSM2A_uc002dhg.3_Missense_Mutation_p.P228R|ACSM2A_uc010vay.1_Missense_Mutation_p.P149R	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	228	ATP.				fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						AGTGGTCTTCCCAAGATGGCA	0.507000													20	57					0	0	0.003954	0	0
KIAA0556	23247	broad.mit.edu	37	16	27761006	27761006	+	Missense_Mutation	SNP	T	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr16:27761006T>A	uc002dow.2	+	16	2749	c.2725T>A	c.(2725-2727)TCC>ACC	p.S909T		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	909										ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						CTTCGACCGCTCCCACCGGGG	0.637000													21	63					0	0	0.008871	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29884867	29884867	+	Missense_Mutation	SNP	T	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr16:29884867T>A	uc002duq.3	-	13	2528	c.2288A>T	c.(2287-2289)AAA>ATA	p.K763I	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.K693I|SEZ6L2_uc002dur.3_Missense_Mutation_p.K693I|SEZ6L2_uc002dus.3_Missense_Mutation_p.K649I|SEZ6L2_uc010vec.1_Missense_Mutation_p.K763I|SEZ6L2_uc010ved.1_Missense_Mutation_p.K719I	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	763	Sushi 4.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						ACAGGCGCATTTGGGGACCCT	0.667000													10	45					0	0	0.008291	0	0
HEATR3	55027	broad.mit.edu	37	16	50104088	50104088	+	Splice_Site	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr16:50104088G>A	uc002efw.2	+	4	562	c.400_splice	c.e4-1	p.C134_splice	HEATR3_uc002efx.2_Splice_Site_p.C48_splice	NM_182922	NP_891552	Q7Z4Q2	HEAT3_HUMAN	HEAT repeat containing 3								binding			ovary(1)|skin(1)	2						TTTGGTTACAGTGTAGTGCTG	0.383000													29	26					0	0	0.007291	0	0
AMFR	267	broad.mit.edu	37	16	56401438	56401438	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr16:56401438C>A	uc002eiy.2	-	12	1722	c.1517G>T	c.(1516-1518)CGG>CTG	p.R506L	AMFR_uc002eix.2_Missense_Mutation_p.R140L	NM_001144	NP_001135	Q9UKV5	AMFR2_HUMAN	autocrine motility factor receptor	506					endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein oligomerization|protein polyubiquitination	integral to endoplasmic reticulum membrane|integral to membrane of membrane fraction	protein binding|protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)	2						GCTATCTGACCGCTGGAAGAG	0.498000													90	254					3.82636e-28	4.68729e-28	0.003610	1	0
HYDIN	54768	broad.mit.edu	37	16	70866949	70866949	+	Missense_Mutation	SNP	T	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr16:70866949T>A	uc002ezr.2	-	80	13826	c.13698A>T	c.(13696-13698)AAA>AAT	p.K4566N	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4567										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				GAGGCTCAAATTTTTTGATGT	0.413000													8	22					0	0	0.000978	0	0
GRB7	2886	broad.mit.edu	37	17	37898588	37898588	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr17:37898588A>G	uc002hsr.2	+	2	284	c.34A>G	c.(34-36)AGC>GGC	p.S12G	GRB7_uc002hss.2_Missense_Mutation_p.S12G|GRB7_uc010cwc.2_Missense_Mutation_p.S12G|GRB7_uc002hst.2_Missense_Mutation_p.S12G	NM_005310	NP_005301	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	12					blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TCATCTTAGCAGCTCTCCGGA	0.617000													92	131					0	0	0.003610	0	0
KRT13	3860	broad.mit.edu	37	17	39658827	39658827	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr17:39658827G>A	uc002hwu.1	-	6	1106	c.1043C>T	c.(1042-1044)ACG>ATG	p.T348M	KRT13_uc002hwv.1_Missense_Mutation_p.T348M|KRT13_uc002hww.2_Missense_Mutation_p.T241M|KRT13_uc010wfr.1_Missense_Mutation_p.T241M|KRT13_uc010cxo.2_Missense_Mutation_p.T348M|KRT13_uc002hwx.1_Missense_Mutation_p.T336M	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	348	Rod.|Coil 2.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				CTCTGCCACCGTGTTCTCCAG	0.632000													5	133					0	0	0.000602	0	0
CDK5RAP3	80279	broad.mit.edu	37	17	46058013	46058013	+	Silent	SNP	C	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr17:46058013C>T	uc002imr.2	+	12	1216	c.1132C>T	c.(1132-1134)CTG>TTG	p.L378L	CDK5RAP3_uc010wlc.1_Silent_p.L398L|CDK5RAP3_uc002imq.1_Silent_p.L153L|CDK5RAP3_uc002imu.2_Silent_p.L222L|CDK5RAP3_uc002ims.2_Silent_p.L291L|CDK5RAP3_uc002imv.2_Silent_p.L222L|CDK5RAP3_uc002imw.2_Silent_p.L220L|CDK5RAP3_uc002imx.2_Silent_p.L153L	NM_176096	NP_788276	Q96JB5	CK5P3_HUMAN	CDK5 regulatory subunit associated protein 3	378					brain development|regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation		neuronal Cdc2-like kinase binding				0						GGCAGATGTCCTGTCTGTGAG	0.473000													12	173					0	0	0.000978	0	0
POTEC	388468	broad.mit.edu	37	18	14513764	14513764	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr18:14513764C>T	uc010dln.2	-	10	1884	c.1430G>A	c.(1429-1431)CGG>CAG	p.R477Q	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	477										skin(3)	3						AAGTTGTTTCCGGGTATCATT	0.358000													4	66					0	0	0.001168	0	0
RANBP3	8498	broad.mit.edu	37	19	5941706	5941706	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr19:5941706T>C	uc002mdw.2	-	5	559	c.332A>G	c.(331-333)GAA>GGA	p.E111G	RANBP3_uc002mdx.2_Missense_Mutation_p.E111G|RANBP3_uc002mdy.2_Missense_Mutation_p.E43G|RANBP3_uc002mdz.2_Missense_Mutation_p.E43G|RANBP3_uc010duq.2_5'UTR|RANBP3_uc002mea.2_Intron|RANBP3_uc010xix.1_Intron	NM_007322	NP_015561	Q9H6Z4	RANB3_HUMAN	RAN binding protein 3 isoform RANBP3-d	111					intracellular transport|protein transport	cytoplasm|nucleus	Ran GTPase binding			breast(1)	1						ATTTCCATCTTCTCTGTCAGA	0.423000													27	62					0	0	0.004656	0	0
ZNF101	94039	broad.mit.edu	37	19	19789581	19789581	+	Silent	SNP	G	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr19:19789581G>C	uc002nni.1	+	3	287	c.177G>C	c.(175-177)CTG>CTC	p.L59L	ZNF101_uc010ecg.1_5'UTR|ZNF101_uc002nnj.1_5'UTR	NM_033204	NP_149981	Q8IZC7	ZN101_HUMAN	zinc finger protein 101	59	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						ACCAAAACCTGGGGATTAAGC	0.333000													7	27					0	0	0.003080	0	0
ZFP14	57677	broad.mit.edu	37	19	36831515	36831515	+	Missense_Mutation	SNP	A	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr19:36831515A>C	uc002odx.1	-	4	1306	c.1213T>G	c.(1213-1215)TTT>GTT	p.F405V	ZFP14_uc010xtd.1_Missense_Mutation_p.F406V|ZFP14_uc010eex.1_Missense_Mutation_p.F405V	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	405	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)					TAACTACTAAAGGTCTTCCAA	0.408000													29	72					0	0	0.001786	0	0
Unknown	0	broad.mit.edu	37	2	96593016	96593016	+	RNA	SNP	C	A	A	rs79307257	by1000genomes	TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr2:96593016C>A	uc002sva.1	-	9		c.389G>T			uc010yug.1_RNA|uc002svc.1_RNA					Homo sapiens cDNA FLJ41632 fis, clone FCBBF1000297, highly  similar to Human protein immuno-reactive with anti-PTH polyclonal antibodies mRNA.																		GAAACAGAATCTTTCTCATCA	0.318000													4	65					0.000274275	0.000316223	0.004482	1	0
CIR1	9541	broad.mit.edu	37	2	175215408	175215408	+	Silent	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr2:175215408T>C	uc002uim.2	-	9	750	c.657A>G	c.(655-657)AAA>AAG	p.K219K	CIR1_uc002uin.2_Silent_p.K93K|CIR1_uc002uio.2_Silent_p.K46K|CIR1_uc002uip.2_Silent_p.K108K	NM_004882	NP_004873	Q86X95	CIR1_HUMAN	CBF1 interacting corepressor	219	Interaction with RP9 (By similarity).|Lys/Ser-rich.				mRNA processing|negative regulation of transcription, DNA-dependent|RNA splicing	nuclear speck	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			large_intestine(1)	1						TCTGTTTTTGTTTGGTTGTTA	0.303000													4	48					0	0	0.000248	0	0
STK36	27148	broad.mit.edu	37	2	219556970	219556970	+	Silent	SNP	C	G	G			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr2:219556970C>G	uc002viu.2	+	15	2135	c.1869C>G	c.(1867-1869)CTC>CTG	p.L623L	STK36_uc002viv.2_Silent_p.L623L|STK36_uc002viw.2_5'Flank	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	623					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		TGGATGGGCTCCTTCATGGCT	0.537000													53	55					0	0	0.003610	0	0
ECEL1	9427	broad.mit.edu	37	2	233350797	233350797	+	Silent	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr2:233350797G>A	uc002vsv.2	-	2	772	c.567C>T	c.(565-567)GAC>GAT	p.D189D	ECEL1_uc010fya.1_Silent_p.D189D|ECEL1_uc010fyb.1_5'UTR	NM_004826	NP_004817	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	189	Lumenal (Potential).				neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)	2		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TCTCGCGCATGTCGAGGCACG	0.582000													5	19					0	0	0.001984	0	0
CHGB	1114	broad.mit.edu	37	20	5903930	5903930	+	Silent	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr20:5903930T>C	uc002wmg.2	+	4	1446	c.1140T>C	c.(1138-1140)AGT>AGC	p.S380S	CHGB_uc010zqz.1_Silent_p.S63S	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	380						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						GTGAGGAGAGTTGGGATGAGG	0.547000													38	135					0	0	0.007835	0	0
PLUNC	51297	broad.mit.edu	37	20	31825663	31825663	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr20:31825663G>A	uc002wyv.2	+	2	216	c.146G>A	c.(145-147)GGA>GAA	p.G49E	PLUNC_uc002wyt.3_Missense_Mutation_p.G49E|PLUNC_uc002wyu.3_Missense_Mutation_p.G49E	NM_130852	NP_570913	Q9NP55	PLUNC_HUMAN	palate, lung and nasal epithelium associated	49					innate immune response	extracellular region	lipid binding				0						GGTCTTGCAGGAAGCTTGACA	0.398000													33	55					0	0	0.003271	0	0
HMGB3L1	128872	broad.mit.edu	37	20	33422211	33422211	+	RNA	SNP	A	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr20:33422211A>C	uc002xax.2	-	1		c.55T>G				NR_002165				Homo sapiens high-mobility group (nonhistone chromosomal) protein 4-like, mRNA (cDNA clone IMAGE:40002762).												0						GTCTGCACAAAGAAGGCAAAA	0.423000													13	47					0	0	0.003163	0	0
MIR499	574501	broad.mit.edu	37	20	33578248	33578248	+	RNA	SNP	A	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr20:33578248A>T	hsa-mir-499|MI0003183	+			c.70A>T			MYH7B_uc002xbi.1_Intron																	0						TCTCCACGTGAACATCACAGC	0.637000													26	23					0	0	0.003954	0	0
TUBB1	81027	broad.mit.edu	37	20	57599037	57599037	+	Silent	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr20:57599037G>A	uc002yak.2	+	4	824	c.555G>A	c.(553-555)GCG>GCA	p.A185A		NM_030773	NP_110400	Q9H4B7	TBB1_HUMAN	beta tubulin 1, class VI	185					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity			ovary(1)	1	all_lung(29;0.00711)		Colorectal(105;0.109)		Colchicine(DB01394)|Docetaxel(DB01248)|Paclitaxel(DB01229)|Vindesine(DB00309)	CCTACAACGCGGTTCTGTCTA	0.517000													21	144					0	0	0.001882	0	0
COL6A1	1291	broad.mit.edu	37	21	47423886	47423886	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr21:47423886G>A	uc002zhu.1	+	35	3148	c.3046G>A	c.(3046-3048)GTC>ATC	p.V1016I	COL6A1_uc010gqd.1_Missense_Mutation_p.V347I|COL6A1_uc002zhv.1_Missense_Mutation_p.V347I|COL6A1_uc002zhw.1_Missense_Mutation_p.V110I	NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	1016	C-terminal globular domain.|VWFA 3.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	GCTCCGCGGTGTCTTCCACCA	0.662000													49	71					0	0	0.003610	0	0
ARVCF	421	broad.mit.edu	37	22	19966432	19966432	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr22:19966432G>A	uc002zqz.2	-	7	1839	c.1568C>T	c.(1567-1569)TCG>TTG	p.S523L	ARVCF_uc002zqy.2_Missense_Mutation_p.S45L	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	523					cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					CAGGCAGCCCGACGTGTTCTT	0.622000													7	28					0	0	0.003080	0	0
C22orf13	83606	broad.mit.edu	37	22	24938994	24938994	+	Missense_Mutation	SNP	A	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr22:24938994A>T	uc003aah.2	-	6	1019	c.703T>A	c.(703-705)TTT>ATT	p.F235I	C22orf13_uc003aal.2_Missense_Mutation_p.F291I|C22orf13_uc003aai.3_Missense_Mutation_p.F191I|C22orf13_uc003aaj.3_Missense_Mutation_p.F234I|C22orf13_uc003aak.3_Missense_Mutation_p.F290I	NM_031444	NP_113632	Q96NT3	CV013_HUMAN	chromosome 22 open reading frame 13	235											0						AAGTAGACAAAGAGGATGTCC	0.637000													27	65					0	0	0.006320	0	0
CSF2RB	1439	broad.mit.edu	37	22	37334445	37334446	+	Missense_Mutation	DNP	GC	TT	TT			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr22:37334445_37334446GC>TT	uc003aqa.3	+	14	2812_2813	c.2595_2596GC>TT	c.(2593-2598)GTGCCC>GTTTCC	p.P866S	CSF2RB_uc003aqc.3_Missense_Mutation_p.P872S	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	866	Cytoplasmic (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	GCCAGGCTGTGCCCCAGGTGCC	0.589000													30	112					0	0	0.004672	0	0
JAGN1	84522	broad.mit.edu	37	3	9934676	9934676	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr3:9934676G>A	uc003btt.3	+	2	303	c.167G>A	c.(166-168)AGC>AAC	p.S56N	CIDEC_uc003bto.2_Intron	NM_032492	NP_115881	Q8N5M9	JAGN1_HUMAN	jagunal homolog 1	56	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(1)	1	Medulloblastoma(99;0.227)					GCTAAGATGAGCGTGGGACAC	0.512000													18	52					0	0	0.007413	0	0
APEH	327	broad.mit.edu	37	3	49720689	49720689	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr3:49720689A>G	uc003cxf.2	+	22	2513	c.2113A>G	c.(2113-2115)AGC>GGC	p.S705G	APEH_uc010hkw.1_Missense_Mutation_p.S710G	NM_001640	NP_001631	P13798	ACPH_HUMAN	N-acylaminoacyl-peptide hydrolase	705					proteolysis	cytoplasm|nuclear membrane	serine-type endopeptidase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CTATCCCAAAAGCACCCACGC	0.557000													53	227					0	0	0.003610	0	0
ACY1	95	broad.mit.edu	37	3	52022538	52022538	+	Splice_Site	SNP	A	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr3:52022538A>C	uc003dcp.2	+	13	983	c.922_splice	c.e13-2	p.K308_splice	ACY1_uc011bea.1_Splice_Site_p.K398_splice|ACY1_uc003dcq.2_Splice_Site_p.K308_splice	NM_000666	NP_000657	Q03154	ACY1_HUMAN	aminoacylase 1						cellular amino acid metabolic process|proteolysis	cytosol	aminoacylase activity|metal ion binding|metallopeptidase activity			breast(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	L-Aspartic Acid(DB00128)	CCTGTCCCTCAGAAGTGGATG	0.512000													12	43					0	0	0.001855	0	0
STAB1	23166	broad.mit.edu	37	3	52554291	52554291	+	Nonsense_Mutation	SNP	C	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr3:52554291C>A	uc003dej.2	+	52	5558	c.5484C>A	c.(5482-5484)TGC>TGA	p.C1828*	STAB1_uc003dek.1_5'UTR|STAB1_uc003del.2_5'Flank	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	1828	Extracellular (Potential).|FAS1 6.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CTTTCTCCTGCAGCCGAACGC	0.632000													16	123					3.45872e-05	4.08379e-05	0.004007	1	0
MYH15	22989	broad.mit.edu	37	3	108110610	108110610	+	Silent	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr3:108110610G>A	uc003dxa.1	-	38	5544	c.5487C>T	c.(5485-5487)TCC>TCT	p.S1829S		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1829	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						CTCCTACCCTGGATTCTAGTT	0.473000													33	149					0	0	0.003271	0	0
FAM162A	26355	broad.mit.edu	37	3	122128621	122128621	+	Silent	SNP	C	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr3:122128621C>T	uc003eez.2	+	5	498	c.408C>T	c.(406-408)AAC>AAT	p.N136N		NM_014367	NP_055182	Q96A26	F162A_HUMAN	growth and transformation-dependent protein	136						integral to membrane				ovary(1)	1						CAAGCTTGAACTTAGAAAAGA	0.438000													46	61					0	0	0.003610	0	0
PLXNA1	5361	broad.mit.edu	37	3	126730880	126730880	+	Missense_Mutation	SNP	A	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr3:126730880A>C	uc003ejg.2	+	9	2127	c.2123A>C	c.(2122-2124)AAC>ACC	p.N708T		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	731	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		GCCGCACGGAACCTGCCACAG	0.627000													7	68					0	0	0.001855	0	0
ATR	545	broad.mit.edu	37	3	142238533	142238533	+	Silent	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr3:142238533G>A	uc003eux.3	-	24	4482	c.4360C>T	c.(4360-4362)CTA>TTA	p.L1454L		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	1454					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						TGAGGTTCTAGTATTTCCCGA	0.308000								Other_conserved_DNA_damage_response_genes					28	92					0	0	0.006320	0	0
ANP32C	23520	broad.mit.edu	37	4	165118517	165118517	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr4:165118517A>G	uc011cjk.1	-	1	347	c.347T>C	c.(346-348)CTT>CCT	p.L116P	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	116	LRR 4.										0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		GCAATTGAAAAGGTCTAAGCT	0.433000													3	189					0	0	0.004672	0	0
EHMT2	10919	broad.mit.edu	37	6	31864742	31864742	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr6:31864742C>A	uc003nxz.1	-	2	77	c.67G>T	c.(67-69)GCG>TCG	p.A23S	EHMT2_uc003nxy.1_5'Flank|EHMT2_uc011don.1_Missense_Mutation_p.A80S|EHMT2_uc003nya.1_Missense_Mutation_p.A23S|EHMT2_uc003nyb.1_Missense_Mutation_p.A23S|C2_uc003nyc.2_5'Flank|C2_uc011doo.1_5'Flank	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	23					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						AGCAGCAGCGCCCCCATCTCA	0.637000													33	78					3.03874e-20	3.6765e-20	0.003271	1	0
BRD2	6046	broad.mit.edu	37	6	32945266	32945266	+	Silent	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr6:32945266T>C	uc003ocn.3	+	8	2949	c.1248T>C	c.(1246-1248)GCT>GCC	p.A416A	BRD2_uc003oco.2_RNA|BRD2_uc003ocq.3_Silent_p.A416A|BRD2_uc003ocp.3_Silent_p.A296A|BRD2_uc010juh.2_Silent_p.A416A	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	416	Bromo 2.				spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						AGTTTGCTGCTGATGTACGGC	0.517000													34	101					0	0	0.004878	0	0
DNAH8	1769	broad.mit.edu	37	6	38913344	38913344	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr6:38913344T>C	uc003ooe.1	+	78	12058	c.11458T>C	c.(11458-11460)TTT>CTT	p.F3820L	DNAH8_uc003oog.1_Missense_Mutation_p.F269L|uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						ACTTCCACAATTTGCAGAAAT	0.488000													32	71					0	0	0.002445	0	0
SLC35B2	347734	broad.mit.edu	37	6	44224125	44224125	+	Missense_Mutation	SNP	G	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr6:44224125G>C	uc003oxd.2	-	3	450	c.314C>G	c.(313-315)CCG>CGG	p.P105R	SLC35B2_uc011dvt.1_Intron|SLC35B2_uc011dvu.1_Intron	NM_178148	NP_835361	Q8TB61	S35B2_HUMAN	solute carrier family 35, member B2	105					positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|signal transducer activity			ovary(1)|central_nervous_system(1)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CTGCCACATCGGGGTGGTCTC	0.627000													24	56					0	0	0.004656	0	0
MOXD1	26002	broad.mit.edu	37	6	132694134	132694134	+	Missense_Mutation	SNP	A	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr6:132694134A>C	uc003qdf.2	-	3	513	c.414T>G	c.(412-414)GAT>GAG	p.D138E	MOXD1_uc003qde.2_Missense_Mutation_p.D70E	NM_015529	NP_056344	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1 isoform 2	138	Lumenal (Potential).|DOMON.				catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			ovary(1)	1	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		TCACAGTGCTATCCTGGGGAT	0.458000													25	63					0	0	0.006320	0	0
TXLNB	167838	broad.mit.edu	37	6	139563747	139563747	+	Silent	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr6:139563747T>C	uc011eds.1	-	10	2136	c.1971A>G	c.(1969-1971)GCA>GCG	p.A657A		NM_153235	NP_694967	Q8N3L3	TXLNB_HUMAN	taxilin beta	657						cytoplasm				large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		CCTCTGCTGCTGCTCGTGGGG	0.642000													36	80					0	0	0.004878	0	0
HOXA10	3206	broad.mit.edu	37	7	27211695	27211695	+	Silent	SNP	C	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr7:27211695C>T	uc011jzm.1	-	2	1086	c.1056G>A	c.(1054-1056)GAG>GAA	p.E352E	MIR196B_hsa-mir-196b|MI0001150_5'Flank|HOXA10_uc003syw.3_Silent_p.E36E	NM_018951	NP_061824	P31260	HXA10_HUMAN	homeobox A10 isoform a	352	Homeobox.				spermatogenesis		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GAAACTCCTTCTCCAGCTCCA	0.532000													69	92					0	0	0.003610	0	0
TRY6	154754	broad.mit.edu	37	7	142481342	142481342	+	Missense_Mutation	SNP	G	C	C	rs146962136	by1000genomes	TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr7:142481342G>C	uc011ksq.1	+	3	499	c.416G>C	c.(415-417)TGC>TCC	p.C139S	uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|uc003wan.1_Intron|TRY6_uc011ksr.1_RNA	NR_001296				SubName: Full=Protease, serine, 3; Flags: Fragment;												0						GGCACCGAGTGCCTTATCTCC	0.557000													3	44					0	0	0.000248	0	0
NRG1	3084	broad.mit.edu	37	8	32463201	32463201	+	Missense_Mutation	SNP	G	A	A	rs78513616		TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr8:32463201G>A	uc003xiv.2	+	3	917	c.400G>A	c.(400-402)GAG>AAG	p.E134K	NRG1_uc003xip.2_Missense_Mutation_p.A349T|NRG1_uc003xir.2_Missense_Mutation_p.E134K|NRG1_uc010lvl.2_Missense_Mutation_p.E134K|NRG1_uc010lvm.2_Missense_Mutation_p.A134T|NRG1_uc010lvn.2_Missense_Mutation_p.A134T|NRG1_uc003xis.2_Missense_Mutation_p.E134K|NRG1_uc011lbf.1_Missense_Mutation_p.E134K|NRG1_uc010lvo.2_Missense_Mutation_p.E134K|NRG1_uc003xiu.2_Missense_Mutation_p.E134K|NRG1_uc003xiw.2_Missense_Mutation_p.E134K|NRG1_uc003xit.2_Missense_Mutation_p.E134K|NRG1_uc010lvr.2_5'UTR|NRG1_uc010lvs.2_5'UTR|NRG1_uc010lvp.2_Missense_Mutation_p.E100K|NRG1_uc010lvq.2_Missense_Mutation_p.A100T|NRG1_uc003xix.2_Missense_Mutation_p.E24K	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	134	Extracellular (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		GGAATCAAACGGTAAGAGATA	0.398000													20	86					0	0	0.008871	0	0
GPR124	25960	broad.mit.edu	37	8	37692907	37692907	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr8:37692907C>G	uc003xkj.2	+	12	2187	c.1824C>G	c.(1822-1824)TTC>TTG	p.F608L	GPR124_uc010lvy.2_Intron	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124 precursor	608	Extracellular (Potential).				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			TGTCGTCCTTCCACATCAAGG	0.682000													10	14					0	0	0.008291	0	0
GAPVD1	26130	broad.mit.edu	37	9	128121733	128121733	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr9:128121733G>A	uc010mwx.2	+	26	4386	c.4060G>A	c.(4060-4062)GTA>ATA	p.V1354I	GAPVD1_uc004bpp.2_Missense_Mutation_p.V1363I|GAPVD1_uc004bpq.2_Missense_Mutation_p.V1336I|GAPVD1_uc004bpr.2_Missense_Mutation_p.V1315I|GAPVD1_uc004bps.2_Missense_Mutation_p.V1309I|GAPVD1_uc004bpt.2_Missense_Mutation_p.V369I	NM_015635	NP_056450	Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	1354	VPS9.				endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						ATTGTCTAAAGTAGTGACTGC	0.358000													27	98					0	0	0.008361	0	0
AHNAK	79026	broad.mit.edu	37	11	62293750	62293750	+	Frame_Shift_Del	DEL	G	-	-			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr11:62293750delG	uc001ntl.2	-	5	8439	c.8139delC	c.(8137-8139)GACfs	p.D2713fs	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2713					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCAGGTTTAAGTCAATATCAG	0.463													83	177	---	---	---	---					
CASC5	57082	broad.mit.edu	37	15	40914067	40914068	+	Frame_Shift_Del	DEL	TT	-	-			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr15:40914067_40914068delTT	uc010bbs.1	+	11	1844_1845	c.1683_1684delTT	c.(1681-1686)AATTGTfs	p.N561fs	CASC5_uc010ucq.1_Frame_Shift_Del_p.N385fs|CASC5_uc001zme.2_Frame_Shift_Del_p.N535fs|CASC5_uc010bbt.1_Frame_Shift_Del_p.N535fs	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	561_562	Interaction with BUB1 and BUB1B.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TGAATGTAAATTGTAACTCAGT	0.371													21	44	---	---	---	---					
SPTBN5	51332	broad.mit.edu	37	15	42178141	42178141	+	Frame_Shift_Del	DEL	G	-	-			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr15:42178141delG	uc001zos.2	-	7	1540	c.1207delC	c.(1207-1209)CGGfs	p.R403fs		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	438	Spectrin 2.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		AAACTCTCCCGGAGGGCTGCC	0.667													2	4	---	---	---	---					
DNMT1	1786	broad.mit.edu	37	19	10250732	10250732	+	Frame_Shift_Del	DEL	A	-	-			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr19:10250732delA	uc002mng.2	-	32	3928	c.3748delT	c.(3748-3750)TCCfs	p.S1250fs	DNMT1_uc002mne.2_RNA|DNMT1_uc002mnf.2_Frame_Shift_Del_p.S174fs|DNMT1_uc010xlc.1_Frame_Shift_Del_p.S1266fs|DNMT1_uc002mnh.2_Frame_Shift_Del_p.S1145fs|DNMT1_uc010xld.1_Frame_Shift_Del_p.S1250fs	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	1250	Catalytic.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	CTGAGGAAGGAAACCACCAGA	0.612													10	42	---	---	---	---					
ZNF776	284309	broad.mit.edu	37	19	58265245	58265245	+	Frame_Shift_Del	DEL	T	-	-			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr19:58265245delT	uc002qpx.2	+	3	970	c.747delT	c.(745-747)AATfs	p.N249fs	ZNF587_uc002qqb.2_Intron|ZNF776_uc002qqa.2_Frame_Shift_Del_p.N249fs	NM_173632	NP_775903	Q68DI1	ZN776_HUMAN	zinc finger protein 776	249	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0256)		GCAAAAGTAATAGTTTTAATA	0.413													17	48	---	---	---	---					
KDM3A	55818	broad.mit.edu	37	2	86716748	86716749	+	In_Frame_Ins	INS	-	GGG	GGG			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr2:86716748_86716749insGGG	uc002sri.3	+	23	3866_3867	c.3539_3540insGGG	c.(3538-3540)AAG>AAGGGG	p.1180_1181insG	KDM3A_uc010ytj.1_In_Frame_Ins_p.1180_1181insG|KDM3A_uc010ytk.1_In_Frame_Ins_p.1128_1129insG	NM_018433	NP_060903	Q9Y4C1	KDM3A_HUMAN	jumonji domain containing 1A	1180_1181	JmjC.				androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	5						TATGCTGCAAAGGACACGGAGA	0.406													51	84	---	---	---	---					
C21orf7	56911	broad.mit.edu	37	21	30547133	30547133	+	Frame_Shift_Del	DEL	T	-	-			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr21:30547133delT	uc002yne.2	+	8	920	c.649delT	c.(649-651)TTGfs	p.L217fs	C21orf7_uc011acr.1_RNA|C21orf7_uc002ynd.2_RNA|C21orf7_uc010gln.2_RNA|C21orf7_uc002ynf.2_Frame_Shift_Del_p.L217fs|C21orf7_uc010glo.2_Frame_Shift_Del_p.L62fs|C21orf7_uc002yng.2_Frame_Shift_Del_p.L117fs|C21orf7_uc010glp.2_RNA	NM_020152	NP_064537	P57077	TAK1L_HUMAN	chromosome 21 open reading frame 7	217						cytosol|nucleus	protein binding			ovary(2)	2				Colorectal(56;0.248)		GAATCGGACGTTGAGGTTGGC	0.488													19	46	---	---	---	---					
DAG1	1605	broad.mit.edu	37	3	49568641	49568641	+	Frame_Shift_Del	DEL	A	-	-			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr3:49568641delA	uc003cxc.3	+	3	1115	c.697delA	c.(697-699)AACfs	p.N233fs		NM_004393	NP_004384	Q14118	DAG1_HUMAN	dystroglycan 1 preproprotein	233	Required for laminin recognition.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		GGTGGTGAATAACAGACTATT	0.522													10	39	---	---	---	---					
N4BP2	55728	broad.mit.edu	37	4	40122970	40122970	+	Frame_Shift_Del	DEL	A	-	-			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr4:40122970delA	uc003guy.3	+	9	3577	c.3239delA	c.(3238-3240)GAAfs	p.E1080fs	N4BP2_uc010ifq.2_Frame_Shift_Del_p.E1000fs|N4BP2_uc010ifr.2_Frame_Shift_Del_p.E1000fs	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	1080						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						TTTGTTGAAGAAAGTGAGCTT	0.338													25	72	---	---	---	---					
MRPL2	51069	broad.mit.edu	37	6	43023807	43023820	+	Splice_Site	DEL	GCCATCTCTCACCT	-	-			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr6:43023807_43023820delGCCATCTCTCACCT	uc003ots.1	-	4	643	c.520_splice	c.e4+1	p.V174_splice	CUL7_uc011dvb.1_5'Flank|CUL7_uc003otq.2_5'Flank|CUL7_uc010jyh.2_5'Flank|KLC4_uc003otr.1_Intron|MRPL2_uc011dvc.1_Frame_Shift_Del_p.A173fs	NM_015950	NP_057034	Q5T653	RM02_HUMAN	mitochondrial ribosomal protein L2 precursor						translation	mitochondrion|ribosome	structural constituent of ribosome				0		Ovarian(999;0.0014)	Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00708)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)	BRCA - Breast invasive adenocarcinoma(397;0.0026)		ACATCTGGTAGCCATCTCTCACCTGCCATTCGGC	0.533													9	37	---	---	---	---					
PON2	5445	broad.mit.edu	37	7	95035516	95035516	+	Frame_Shift_Del	DEL	G	-	-	rs77619496	byFrequency	TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08									Somatic	Phase_I	Capture				Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr7:95035516delG	uc003unv.2	-	8	942	c.821delC	c.(820-822)CCTfs	p.P274fs	PON2_uc003unu.2_Frame_Shift_Del_p.P262fs|PON2_uc010lfk.2_RNA|PON2_uc003unw.2_Frame_Shift_Del_p.P187fs	NM_000305	NP_000296	Q15165	PON2_HUMAN	paraoxonase 2 isoform 1	274					aromatic compound catabolic process	extracellular region|plasma membrane	arylesterase activity|identical protein binding|metal ion binding				0	all_cancers(62;9.35e-11)|all_epithelial(64;3.37e-09)		STAD - Stomach adenocarcinoma(171;0.0151)			CCCCGAGGAAGGATCAATAGA	0.398													13	233	---	---	---	---					
