Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MRPL20	55052	broad.mit.edu	37	1	1342391	1342392	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr1:1342391_1342392CC>AA	uc001afo.3	-	2	191_192	c.95_96GG>TT	c.(94-96)CGG>CTT	p.R32L	MRPL20_uc010nyn.1_Missense_Mutation_p.R32L	NM_017971	NP_060441	Q9BYC9	RM20_HUMAN	mitochondrial ribosomal protein L20 precursor	32							protein binding|rRNA binding				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		TTTTCCTTCCCCGGAAGTGCTG	0.495													9	231					0	0	6.4e-05	0	0
PRDM2	7799	broad.mit.edu	37	1	14068533	14068533	+	Missense_Mutation	SNP	G	T	T			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr1:14068533G>T	uc001avi.2	+	5	1121	c.265G>T	c.(265-267)GAT>TAT	p.D89Y	PRDM2_uc001avg.2_Missense_Mutation_p.D89Y|PRDM2_uc001avh.2_Missense_Mutation_p.D89Y|PRDM2_uc001avj.2_RNA	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	89	SET.					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		GATGTGCATTGATGCCACTGA	0.383													26	27					6.07407e-21	3.87302e-19	0.000184323	1	0
INSRR	3645	broad.mit.edu	37	1	156818724	156818724	+	Silent	SNP	G	A	A			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr1:156818724G>A	uc010pht.1	-	7	1814	c.1560C>T	c.(1558-1560)TAC>TAT	p.Y520Y	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	520	Fibronectin type-III 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					ACTCCTTGTAGTACACGATGA	0.532													3	5					0	0	6.4e-05	0	0
CACNA1S	779	broad.mit.edu	37	1	201042689	201042690	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr1:201042689_201042690GG>TT	uc001gvv.2	-	15	2371_2372	c.2144_2145CC>AA	c.(2143-2145)CCC>CAA	p.P715Q		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	715	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TGGCAGTGGTGGGGATGCCCTC	0.55													13	416					0	0	6.4e-05	0	0
NEK2	4751	broad.mit.edu	37	1	211843673	211843673	+	Missense_Mutation	SNP	G	C	C			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr1:211843673G>C	uc001hir.1	-	5	861	c.715C>G	c.(715-717)CGT>GGT	p.R239G	NEK2_uc001hiq.1_Missense_Mutation_p.R239G|NEK2_uc001his.3_Missense_Mutation_p.R239G|NEK2_uc001hit.1_RNA	NM_002497	NP_002488	P51955	NEK2_HUMAN	NIMA-related kinase 2	239	Protein kinase.				cell division|centrosome separation|G2/M transition of mitotic cell cycle|meiosis|protein autophosphorylation|regulation of mitosis	centrosome|condensed chromosome kinetochore|cytosol|nucleolus	ATP binding|metal ion binding|protein binding|protein phosphatase binding|protein serine/threonine kinase activity			breast(2)|stomach(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.00203)|all cancers(67;0.0339)|Epithelial(68;0.0546)		TCAGAGTAACGGTATGGAATT	0.363													4	181					0	0	1.23904e-05	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232577052	232577053	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr1:232577052_232577053GG>TT	uc001hvg.2	-	12	3784_3785	c.3626_3627CC>AA	c.(3625-3627)CCC>CAA	p.P1209Q	SIPA1L2_uc001hvf.2_Missense_Mutation_p.P283Q	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1209					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				AAAGCTTATTGGGGGAATCTTT	0.475													9	506					0	0	6.4e-05	0	0
PCDH15	65217	broad.mit.edu	37	10	55568839	55568839	+	Missense_Mutation	SNP	T	A	A			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr10:55568839T>A	uc010qhs.1	-	37	5381	c.4986A>T	c.(4984-4986)AAA>AAT	p.K1662N	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qht.1_Missense_Mutation_p.K1655N|PCDH15_uc010qhu.1_3'UTR	NM_001142769	NP_001136241	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD2-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GCACAATGTTTTTCCTTGCTT	0.393										HNSCC(58;0.16)			13	14					0	0	0.00010058	0	0
AP3M1	26985	broad.mit.edu	37	10	75898090	75898090	+	Silent	SNP	T	C	C	rs147488745		TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr10:75898090T>C	uc001jwf.2	-	2	478	c.48A>G	c.(46-48)CTA>CTG	p.L16L	AP3M1_uc001jwg.2_Silent_p.L16L|AP3M1_uc001jwh.2_Silent_p.L16L|AP3M1_uc010qla.1_Silent_p.L16L	NM_207012	NP_996895	Q9Y2T2	AP3M1_HUMAN	adaptor-related protein complex 3, mu 1 subunit	16					protein targeting to lysosome|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus|lysosome	protein binding				0	Prostate(51;0.0112)					AGTGCTTCTCTAGAAATATGT	0.358													38	35					0	0	7.51294e-05	0	0
MADD	8567	broad.mit.edu	37	11	47311021	47311022	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr11:47311021_47311022CC>AA	uc001ner.1	+	17	2984_2985	c.2793_2794CC>AA	c.(2791-2796)CCCCAG>CCAAAG	p.Q932K	MADD_uc001neq.2_Missense_Mutation_p.Q912K|MADD_uc001nev.1_Missense_Mutation_p.Q869K|MADD_uc001nes.1_Missense_Mutation_p.Q889K|MADD_uc001net.1_Missense_Mutation_p.Q932K|MADD_uc009yln.1_Missense_Mutation_p.Q869K|MADD_uc001neu.1_Missense_Mutation_p.Q869K|MADD_uc001nex.2_Missense_Mutation_p.Q932K|MADD_uc001nez.2_Missense_Mutation_p.Q869K|MADD_uc001new.2_Missense_Mutation_p.Q912K|MADD_uc009ylo.2_5'Flank	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	932					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		CTCCATCACCCCAGGGTCGATC	0.48													9	162					0	0	6.4e-05	0	0
Unknown	0	broad.mit.edu	37	11	55065601	55065601	+	RNA	SNP	C	G	G	rs4100282		TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr11:55065601C>G	uc001nhl.1	-	1		c.108G>C								Homo sapiens mRNA for hypothetical protein, partial sequence, clone:Hsa11-digit20-11-30-F.																		CACTGAGCAACAACTGCCATG	0.488													3	25					0	0	6.4e-05	0	0
OR8I2	120586	broad.mit.edu	37	11	55861472	55861472	+	Missense_Mutation	SNP	C	G	G			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr11:55861472C>G	uc010rix.1	+	1	689	c.689C>G	c.(688-690)GCA>GGA	p.A230G		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	230	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					ATCCAGTCAGCAGCAGGCAGG	0.468													21	56					0	0	3.10358e-05	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57076186	57076186	+	Silent	SNP	C	T	T			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr11:57076186C>T	uc001njr.2	-	5	4311	c.3999G>A	c.(3997-3999)GGG>GGA	p.G1333G	TNKS1BP1_uc001njs.2_Silent_p.G1333G|TNKS1BP1_uc009ymd.1_Silent_p.G784G	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	1333	Gly-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				ATCCCCGTAGCCCCTGAGAAC	0.607													71	106					0	0	0.000147903	0	0
DSCAML1	57453	broad.mit.edu	37	11	117375681	117375681	+	Missense_Mutation	SNP	C	T	T			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr11:117375681C>T	uc001prh.1	-	10	2322	c.2320G>A	c.(2320-2322)GAC>AAC	p.D774N		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	714	Extracellular (Potential).|Ig-like C2-type 8.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GGGTAGCCGTCCACCGAGCAG	0.602													25	31					0	0	5.49717e-05	0	0
LIMA1	51474	broad.mit.edu	37	12	50571511	50571511	+	Missense_Mutation	SNP	C	G	G			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr12:50571511C>G	uc001rwj.3	-	11	1790	c.1616G>C	c.(1615-1617)GGA>GCA	p.G539A	LIMA1_uc001rwg.3_Missense_Mutation_p.G237A|LIMA1_uc001rwh.3_Missense_Mutation_p.G378A|LIMA1_uc001rwi.3_Missense_Mutation_p.G380A|LIMA1_uc001rwk.3_Missense_Mutation_p.G540A|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	539					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						TCCTGAACTTCCAAGTTCAGT	0.532													71	85					0	0	0.000147903	0	0
LAMP1	3916	broad.mit.edu	37	13	113964011	113964011	+	Silent	SNP	C	T	T			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr13:113964011C>T	uc001vtm.1	+	3	518	c.237C>T	c.(235-237)TCC>TCT	p.S79S	LAMP1_uc010tka.1_Silent_p.S79S	NM_005561	NP_005552	P11279	LAMP1_HUMAN	lysosomal-associated membrane protein 1	79	Lumenal (Potential).|First lumenal domain.					endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				central_nervous_system(2)	2	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			ACCGCAGCTCCTGTGGAAAAG	0.448													50	38					0	0	0.000147903	0	0
BAZ1A	11177	broad.mit.edu	37	14	35242930	35242930	+	Silent	SNP	A	G	G			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr14:35242930A>G	uc001wsk.2	-	20	3568	c.3000T>C	c.(2998-3000)GTT>GTC	p.V1000V	BAZ1A_uc001wsl.2_Silent_p.V968V	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1000					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		GTCGATCTGTAACCTGTAACA	0.323													19	16					0	0	4.16121e-05	0	0
ESR2	2100	broad.mit.edu	37	14	64746749	64746749	+	Missense_Mutation	SNP	C	G	G			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr14:64746749C>G	uc001xha.1	-	3	953	c.485G>C	c.(484-486)GGA>GCA	p.G162A	ESR2_uc001xgu.2_Missense_Mutation_p.G162A|ESR2_uc001xgv.2_Missense_Mutation_p.G162A|ESR2_uc001xgw.2_RNA|ESR2_uc001xgx.2_Missense_Mutation_p.G162A|ESR2_uc001xgy.1_Missense_Mutation_p.G162A|ESR2_uc001xgz.1_Missense_Mutation_p.G162A|ESR2_uc010aqb.1_Intron|ESR2_uc010aqc.1_Missense_Mutation_p.G162A	NM_001437	NP_001428	Q92731	ESR2_HUMAN	estrogen receptor beta isoform 1	162	NR C4-type.|Nuclear receptor.				cell-cell signaling|negative regulation of cell growth|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	mitochondrion|nucleoplasm	enzyme binding|estrogen receptor activity|receptor antagonist activity|sequence-specific DNA binding transcription factor activity|steroid binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3				all cancers(60;0.00916)|OV - Ovarian serous cystadenocarcinoma(108;0.0111)|BRCA - Breast invasive adenocarcinoma(234;0.0437)	Bicalutamide(DB01128)|Estradiol(DB00783)|Estramustine(DB01196)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Trilostane(DB01108)	CGACCAGACTCCATAGTGATA	0.453													120	157					0	0	0.000147903	0	0
ARHGAP11B	89839	broad.mit.edu	37	15	30938440	30938440	+	RNA	SNP	A	G	G	rs115448147	by1000genomes	TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr15:30938440A>G	uc010azv.1	+	11		c.1250A>G			ARHGAP11B_uc001zeu.2_RNA			Q3KRB8	RHGBB_HUMAN	Homo sapiens cDNA, FLJ17072.						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		all_lung(180;2.71e-09)|Breast(32;0.00116)		all cancers(64;1.9e-15)|Epithelial(43;3.59e-12)|GBM - Glioblastoma multiforme(186;9e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)|Lung(196;0.153)		CTCCTTTGCTATTTGTGCATG	0.493													5	39					0	0	1.12685e-05	0	0
ARHGAP11B	89839	broad.mit.edu	37	15	30938448	30938448	+	RNA	SNP	A	G	G	rs146574312	by1000genomes	TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr15:30938448A>G	uc010azv.1	+	11		c.1258A>G			ARHGAP11B_uc001zeu.2_RNA			Q3KRB8	RHGBB_HUMAN	Homo sapiens cDNA, FLJ17072.						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		all_lung(180;2.71e-09)|Breast(32;0.00116)		all cancers(64;1.9e-15)|Epithelial(43;3.59e-12)|GBM - Glioblastoma multiforme(186;9e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)|Lung(196;0.153)		CTATTTGTGCATGGTGGCTGG	0.483													4	34					0	0	0.000157383	0	0
TTBK2	146057	broad.mit.edu	37	15	43038031	43038031	+	Missense_Mutation	SNP	G	T	T			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr15:43038031G>T	uc001zqo.2	-	15	4136	c.3697C>A	c.(3697-3699)CAA>AAA	p.Q1233K	TTBK2_uc010bcy.2_Missense_Mutation_p.Q1164K|uc001zqn.2_5'Flank	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	1233					cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		CTCTTCCCTTGGGGGGTTTTA	0.537													13	201					5.01169e-05	0.00296179	5.01169e-05	1	0
CP110	9738	broad.mit.edu	37	16	19548870	19548870	+	Missense_Mutation	SNP	T	A	A			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr16:19548870T>A	uc002dgl.3	+	4	2126	c.1879T>A	c.(1879-1881)TTC>ATC	p.F627I	CP110_uc002dgk.3_Missense_Mutation_p.F627I			O43303	CP110_HUMAN	RecName: Full=Centrosomal protein of 110 kDa;          Short=Cep110;	627					centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding				0						GGGATCTGGCTTCGTTAACAA	0.348													22	33					0	0	0.000229342	0	0
TNRC6A	27327	broad.mit.edu	37	16	24826534	24826534	+	Missense_Mutation	SNP	G	A	A			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr16:24826534G>A	uc002dmm.2	+	19	4853	c.4739G>A	c.(4738-4740)AGT>AAT	p.S1580N	TNRC6A_uc010bxs.2_Missense_Mutation_p.S1327N|TNRC6A_uc002dmn.2_Missense_Mutation_p.S1278N|TNRC6A_uc002dmo.2_Missense_Mutation_p.S1219N|TNRC6A_uc002dmp.2_Missense_Mutation_p.S181N|TNRC6A_uc002dmq.2_Missense_Mutation_p.S247N	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1580					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		ATGAACAGCAGTACTTCACCA	0.458													32	83					0	0	3.70037e-05	0	0
SLC5A11	115584	broad.mit.edu	37	16	24883521	24883522	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr16:24883521_24883522CC>AA	uc002dmu.2	+	5	585_586	c.353_354CC>AA	c.(352-354)CCC>CAA	p.P118Q	SLC5A11_uc002dms.2_Missense_Mutation_p.P54Q|SLC5A11_uc010vcd.1_Missense_Mutation_p.P118Q|SLC5A11_uc002dmt.2_Missense_Mutation_p.P54Q|SLC5A11_uc010vce.1_Missense_Mutation_p.P83Q|SLC5A11_uc010bxt.2_Missense_Mutation_p.P54Q	NM_052944	NP_443176	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/glucose	118	Helical; (Potential).				apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0365)		ATCTTCCTACCCATCTACATTG	0.53													12	636					0	0	6.4e-05	0	0
C16orf93	90835	broad.mit.edu	37	16	30770380	30770381	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr16:30770380_30770381GG>TT	uc002dzm.2	-	8	1100_1101	c.769_770CC>AA	c.(769-771)CCG>AAG	p.P257K	C16orf93_uc002dzn.2_Missense_Mutation_p.P322K|C16orf93_uc002dzo.2_Missense_Mutation_p.P220K	NM_001014979	NP_001014979	A1A4V9	CP093_HUMAN	hypothetical protein LOC90835	257											0						CTCTTTCTGCGGGGTAACTGCC	0.599													15	427					0	0	6.4e-05	0	0
ITGAM	3684	broad.mit.edu	37	16	31338218	31338219	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr16:31338218_31338219CC>AA	uc002ebq.2	+	22	2768_2769	c.2670_2671CC>AA	c.(2668-2673)TCCCTT>TCAATT	p.L891I	ITGAM_uc002ebr.2_Missense_Mutation_p.L892I|ITGAM_uc010can.2_Missense_Mutation_p.L297I|ITGAM_uc002ebs.1_Missense_Mutation_p.L297I	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	891	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						CTAAGGCTTCCCTTGGAAACAA	0.441													9	322					0	0	6.4e-05	0	0
AMFR	267	broad.mit.edu	37	16	56401373	56401374	+	Nonsense_Mutation	DNP	CC	AA	AA			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr16:56401373_56401374CC>AA	uc002eiy.2	-	12	1786_1787	c.1581_1582GG>TT	c.(1579-1584)GAGGGA>GATTGA	p.527_528EG>D*	AMFR_uc002eix.2_Nonsense_Mutation_p.161_162EG>D*	NM_001144	NP_001135	Q9UKV5	AMFR2_HUMAN	autocrine motility factor receptor	527_528					endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein oligomerization|protein polyubiquitination	integral to endoplasmic reticulum membrane|integral to membrane of membrane fraction	protein binding|protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)	2						GAAGTTTCTCCCTCTTCCTGGT	0.52													16	642					0	0	6.4e-05	0	0
CNOT1	23019	broad.mit.edu	37	16	58585134	58585134	+	Missense_Mutation	SNP	T	C	C			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr16:58585134T>C	uc002env.2	-	24	3537	c.3244A>G	c.(3244-3246)ACA>GCA	p.T1082A	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.T1077A|CNOT1_uc002enx.2_Missense_Mutation_p.T1082A|CNOT1_uc002enz.1_Missense_Mutation_p.T511A|CNOT1_uc010vik.1_Missense_Mutation_p.T78A|SNORA46_uc002eny.1_5'Flank	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1082					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GTTTGATCTGTGGCCACAAGC	0.323													227	134					0	0	0.000147903	0	0
KARS	3735	broad.mit.edu	37	16	75670417	75670418	+	Missense_Mutation	DNP	CC	AA	AA	rs139268669		TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr16:75670417_75670418CC>AA	uc002feq.2	-	4	464_465	c.416_417GG>TT	c.(415-417)GGG>GTT	p.G139V	KARS_uc002fer.2_Missense_Mutation_p.G167V|KARS_uc002fes.2_5'UTR|KARS_uc010cgz.2_5'UTR	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	139					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			ovary(2)	2					L-Lysine(DB00123)	TGAGCTTTCCCCCAGAAGCTCT	0.416													11	284					0	0	6.4e-05	0	0
GP1BA	2811	broad.mit.edu	37	17	4837101	4837101	+	Missense_Mutation	SNP	C	T	T			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr17:4837101C>T	uc010vsq.1	+	2	1277	c.1202C>T	c.(1201-1203)ACC>ATC	p.T401I	uc002fzn.1_RNA	NM_000173	NP_000164	P07359	GP1BA_HUMAN	platelet glycoprotein Ib alpha polypeptide	401											0						AACATGACCACCCTGGAGCCC	0.363													13	38					0	0	0.00010058	0	0
MIS12	79003	broad.mit.edu	37	17	5392722	5392723	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr17:5392722_5392723CC>AA	uc002gcd.2	+	2	869_870	c.540_541CC>AA	c.(538-543)TCCCTG>TCAATG	p.L181M	MIS12_uc002gce.2_Missense_Mutation_p.L181M	NM_024039	NP_076944	Q9H081	MIS12_HUMAN	MIS12 homolog	181	Potential.				cell division|chromosome segregation|kinetochore assembly|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding				0						GTTTAGTATCCCTGGTTCAGAA	0.391													9	255					0	0	6.4e-05	0	0
UBB	7314	broad.mit.edu	37	17	16285476	16285476	+	Silent	SNP	C	G	G			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr17:16285476C>G	uc002gpx.2	+	2	393	c.255C>G	c.(253-255)ACC>ACG	p.T85T	UBB_uc010vwe.1_Intron	NM_018955	NP_061828	P0CG47	UBB_HUMAN	ubiquitin B precursor	85	Ubiquitin-like 2.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		AGACCCTGACCGGCAAGACCA	0.552													4	140					0	0	0.00024832	0	0
BLMH	642	broad.mit.edu	37	17	28601215	28601215	+	Missense_Mutation	SNP	T	C	C			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr17:28601215T>C	uc002hez.1	-	7	883	c.646A>G	c.(646-648)ATA>GTA	p.I216V	BLMH_uc010wbn.1_Missense_Mutation_p.I129V	NM_000386	NP_000377	Q13867	BLMH_HUMAN	bleomycin hydrolase	216					proteolysis	cytoplasm|nucleus	aminopeptidase activity|carboxypeptidase activity|cysteine-type endopeptidase activity|protein binding			ovary(1)	1						ACTCGGAATATCTGGAAGAGA	0.408													12	52					0	0	0.00010058	0	0
TBC1D3	729873	broad.mit.edu	37	17	36288288	36288289	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr17:36288288_36288289CC>AA	uc002hoo.2	+	6	531_532	c.374_375CC>AA	c.(373-375)CCC>CAA	p.P125Q	TBC1D3_uc002hop.2_RNA|TBC1D3_uc010wdj.1_Missense_Mutation_p.P45Q|TBC1D3_uc010cvf.1_Missense_Mutation_p.P125Q|TBC1D3_uc002hoq.2_Missense_Mutation_p.P125Q|TBC1D3_uc010wdk.1_Missense_Mutation_p.P186Q|uc002hpl.2_5'Flank|uc002hor.2_5'Flank	NM_032258	NP_115634	Q8IZP1	TBC3A_HUMAN	TBC1 domain family, member 3F	125	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0	Breast(7;2.97e-12)	Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TTGAAAAACCCCGGAAGATACC	0.574													13	654					0	0	6.4e-05	0	0
MED24	9862	broad.mit.edu	37	17	38182477	38182477	+	Silent	SNP	C	T	T			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr17:38182477C>T	uc002htt.2	-	19	2230	c.1917G>A	c.(1915-1917)TCG>TCA	p.S639S	MED24_uc010wer.1_5'Flank|MED24_uc010wes.1_Silent_p.S499S|MED24_uc010wet.1_Intron|MED24_uc002hts.2_Silent_p.S664S|MED24_uc002htu.2_Silent_p.S626S|MED24_uc010cwn.2_Silent_p.S626S|MED24_uc010weu.1_Silent_p.S549S|MED24_uc010wev.1_Silent_p.S589S|MED24_uc010wew.1_Silent_p.S580S|SNORD124_uc010wey.1_5'Flank	NM_014815	NP_055630	O75448	MED24_HUMAN	mediator complex subunit 24 isoform 1	639					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)					TCATCTGCAGCGACTTCTCAC	0.567													41	130					0	0	0.000191422	0	0
ITGB3	3690	broad.mit.edu	37	17	45369560	45369560	+	Missense_Mutation	SNP	C	T	T			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr17:45369560C>T	uc002ilj.2	+	10	1336	c.1316C>T	c.(1315-1317)TCC>TTC	p.S439F	ITGB3_uc010wkr.1_RNA	NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	439	Extracellular (Potential).				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)	AAGGAGAAGTCCTTTACCATA	0.522													58	32					0	0	0.000147903	0	0
HOXB2	3212	broad.mit.edu	37	17	46620496	46620496	+	Silent	SNP	A	G	G			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr17:46620496A>G	uc002inm.2	-	2	1125	c.1005T>C	c.(1003-1005)CCT>CCC	p.P335P		NM_002145	NP_002136	P14652	HXB2_HUMAN	homeobox B2	335					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CCTCGGAAAAAGGGACCGGGC	0.587													3	129					0	0	6.4e-05	0	0
HSF5	124535	broad.mit.edu	37	17	56540550	56540550	+	Missense_Mutation	SNP	C	G	G			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr17:56540550C>G	uc002iwi.1	-	4	1259	c.1135G>C	c.(1135-1137)GTT>CTT	p.V379L		NM_001080439	NP_001073908	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	379						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AACTCATCAACTATCTGAAAG	0.438													57	132					0	0	0.000147903	0	0
TEX14	56155	broad.mit.edu	37	17	56663339	56663339	+	Missense_Mutation	SNP	G	C	C			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr17:56663339G>C	uc010dcz.1	-	18	3029	c.2911C>G	c.(2911-2913)CCC>GCC	p.P971A	TEX14_uc002iwr.1_Missense_Mutation_p.P965A|TEX14_uc002iws.1_Missense_Mutation_p.P965A|TEX14_uc010dda.1_Missense_Mutation_p.P745A	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	971						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGGGCGTCGGGCTCATTTTCA	0.512													63	162					0	0	0.000147903	0	0
METTL2A	339175	broad.mit.edu	37	17	60501296	60501296	+	Silent	SNP	A	G	G			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr17:60501296A>G	uc002izv.2	+	1	51	c.33A>G	c.(31-33)GCA>GCG	p.A11A	METTL2A_uc002izw.2_5'UTR	NM_181725	NP_859076	Q96IZ6	MTL2A_HUMAN	methyltransferase like 2A	11							methyltransferase activity				0			BRCA - Breast invasive adenocarcinoma(2;1.08e-10)			GTGCACCTGCAGTCCTCGCCG	0.597											OREG0024635	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	40					0	0	0.000132079	0	0
CYB561	1534	broad.mit.edu	37	17	61511913	61511913	+	Silent	SNP	G	A	A			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr17:61511913G>A	uc002jap.2	-	5	1008	c.606C>T	c.(604-606)AAC>AAT	p.N202N	CYB561_uc002jaq.2_Silent_p.N248N|CYB561_uc002jar.2_Silent_p.N202N|CYB561_uc002jas.2_Silent_p.N202N|CYB561_uc010ddt.2_3'UTR|CYB561_uc002jat.2_Silent_p.N202N|CYB561_uc010wpf.1_3'UTR|CYB561_uc010wpg.1_Silent_p.N173N	NM_001915	NP_001906	P49447	CY561_HUMAN	cytochrome b-561	202	Cytochrome b561.|Helical; (Potential).				electron transport chain|transport	integral to plasma membrane	cytochrome-b5 reductase activity|ferric-chelate reductase activity|metal ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(1115;0.0689)		GGCCCAGCACGTTGGCCAGGA	0.642													22	13					0	0	0.000227799	0	0
ABCA5	23461	broad.mit.edu	37	17	67303077	67303077	+	Missense_Mutation	SNP	G	A	A			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr17:67303077G>A	uc002jif.2	-	5	1795	c.577C>T	c.(577-579)CTT>TTT	p.L193F	ABCA5_uc002jig.2_Missense_Mutation_p.L193F|ABCA5_uc002jih.2_Missense_Mutation_p.L193F|ABCA5_uc010dfe.2_Missense_Mutation_p.L193F	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	193					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)					TCCTTCCAAAGAGAAACATTG	0.348													32	61					0	0	7.24521e-05	0	0
NOTUM	147111	broad.mit.edu	37	17	79913365	79913365	+	Silent	SNP	G	A	A			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr17:79913365G>A	uc010wvg.1	-	9	1316	c.1044C>T	c.(1042-1044)AAC>AAT	p.N348N		NM_178493	NP_848588	Q6P988	NOTUM_HUMAN	notum pectinacetylesterase homolog precursor	348						extracellular region	hydrolase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			TCAGGTGCACGTTGTCCACCG	0.687													19	31					0	0	9.7654e-05	0	0
HCN2	610	broad.mit.edu	37	19	615935	615935	+	Missense_Mutation	SNP	G	C	C			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr19:615935G>C	uc002lpe.2	+	8	2184	c.2131G>C	c.(2131-2133)GTG>CTG	p.V711L		NM_001194	NP_001185	Q9UL51	HCN2_HUMAN	hyperpolarization activated cyclic	711	Cytoplasmic (Potential).				cell-cell signaling|muscle contraction	voltage-gated potassium channel complex	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity				0		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGTCAGCGCGTGGGCCTCTT	0.582													3	17					0	0	6.4e-05	0	0
ZNF284	342909	broad.mit.edu	37	19	44590761	44590761	+	Missense_Mutation	SNP	G	C	C			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr19:44590761G>C	uc002oyg.1	+	5	1346	c.1130G>C	c.(1129-1131)GGG>GCG	p.G377A	ZNF284_uc010ejd.2_RNA	NM_001037813	NP_001032902	Q2VY69	ZN284_HUMAN	zinc finger protein 284	377	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0435)				AATGTATGTGGGAAGGGCTTC	0.428													3	98					0	0	0.00024832	0	0
SFRS7	6432	broad.mit.edu	37	2	38978383	38978384	+	Missense_Mutation	DNP	GC	AA	AA			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr2:38978383_38978384GC>AA	uc002rqz.2	-	1	253_254	c.15_16GC>TT	c.(13-18)GGGCGG>GGTTGG	p.R6W	SFRS7_uc002rra.2_RNA|SFRS7_uc010ynp.1_Missense_Mutation_p.R6W|GEMIN6_uc002rrb.2_5'Flank	NM_001031684	NP_001026854	Q16629	SRSF7_HUMAN	splicing factor, arginine/serine-rich 7	6					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding|zinc ion binding				0		all_hematologic(82;0.248)				CCTCCGTACCGCCCGTAACGCG	0.624													27	35					0	0	6.4e-05	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025358	207025358	+	Missense_Mutation	SNP	A	G	G			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr2:207025358A>G	uc002vbf.1	+	3	285	c.127A>G	c.(127-129)AGC>GGC	p.S43G	NDUFS1_uc010ziq.1_5'Flank|NDUFS1_uc002vbe.2_5'Flank|NDUFS1_uc010zir.1_5'Flank|NDUFS1_uc010zis.1_5'Flank|NDUFS1_uc010zit.1_5'Flank|NDUFS1_uc010ziu.1_5'Flank|EEF1B2_uc002vbg.1_Missense_Mutation_p.S43G|EEF1B2_uc002vbh.1_Missense_Mutation_p.S43G|SNORD51_uc002vbi.1_5'Flank|SNORA41_uc002vbj.2_5'Flank	NM_001037663	NP_001032752	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta	43	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity				0						AGCCGTGTCCAGCCCACCGCC	0.468													5	89					0	0	1.23904e-05	0	0
ANKZF1	55139	broad.mit.edu	37	2	220099828	220099828	+	Missense_Mutation	SNP	G	T	T			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr2:220099828G>T	uc002vkg.2	+	10	1659	c.1485G>T	c.(1483-1485)TGG>TGT	p.W495C	ANKZF1_uc010zkv.1_3'UTR|ANKZF1_uc010zkw.1_3'UTR|ANKZF1_uc002vkh.2_Missense_Mutation_p.W285C|ANKZF1_uc002vki.2_Missense_Mutation_p.W495C|ANKZF1_uc002vkj.1_3'UTR	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	495	ANK 1.					intracellular	zinc ion binding			ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CAGAGCTCTGGAATGCACTGC	0.587													21	29					8.10497e-08	4.90959e-06	0.000175454	1	0
RIN2	54453	broad.mit.edu	37	20	19955386	19955386	+	Silent	SNP	C	T	T			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr20:19955386C>T	uc002wro.1	+	7	753	c.717C>T	c.(715-717)TCC>TCT	p.S239S	RIN2_uc010gcu.1_Intron|RIN2_uc010gcv.1_Silent_p.S33S	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	239					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5						GTCCTGCCTCCCTGCGTCAGC	0.547													31	32					0	0	0.000227799	0	0
RBM9	23543	broad.mit.edu	37	22	36206007	36206007	+	Silent	SNP	A	G	G			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr22:36206007A>G	uc003aon.3	-	3	394	c.282T>C	c.(280-282)CCT>CCC	p.P94P	RBM9_uc003aog.3_Silent_p.P4P|RBM9_uc003aol.3_Silent_p.P24P|RBM9_uc003aoj.3_Silent_p.P24P|RBM9_uc003aok.3_Silent_p.P24P|RBM9_uc003aoh.3_Silent_p.P24P|RBM9_uc003aom.3_Silent_p.P24P|RBM9_uc010gwu.2_Silent_p.P4P|RBM9_uc003aoo.3_Silent_p.P94P|RBM9_uc003aop.3_Silent_p.P24P	NM_001082578	NP_001076047	O43251	RFOX2_HUMAN	RNA binding motif protein 9 isoform 5	34					estrogen receptor signaling pathway|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of cell proliferation|RNA splicing	cytoplasm|nucleus	nucleotide binding|RNA binding|transcription corepressor activity|transcription factor binding				0						TGGTAGTAAAAGGCTGAACCA	0.473													51	63					0	0	0.000147903	0	0
PLCL2	23228	broad.mit.edu	37	3	17051783	17051783	+	Missense_Mutation	SNP	G	T	T			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr3:17051783G>T	uc011awc.1	+	5	1026	c.921G>T	c.(919-921)TTG>TTT	p.L307F	PLCL2_uc010het.1_Intron|PLCL2_uc011awd.1_Missense_Mutation_p.L189F	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	315					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						TCAAAGAATTGCATAAATCAA	0.348													46	95					1.7489e-18	1.08656e-16	0.000106405	1	0
CDC25A	993	broad.mit.edu	37	3	48207358	48207359	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr3:48207358_48207359CC>AA	uc003csh.1	-	11	1418_1419	c.1054_1055GG>TT	c.(1054-1056)GGG>TTG	p.G352L	CDC25A_uc003csi.1_Missense_Mutation_p.G312L	NM_001789	NP_001780	P30304	MPIP1_HUMAN	cell division cycle 25A isoform a	352					cell cycle checkpoint|cell division|cell proliferation|cellular response to UV|DNA replication|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding|protein tyrosine phosphatase activity			lung(3)|kidney(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000685)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		CTGATGTTTCCCAGCAACTGTA	0.361													9	305					0	0	6.4e-05	0	0
C3orf27	23434	broad.mit.edu	37	3	128292497	128292497	+	Missense_Mutation	SNP	C	T	T	rs141693917		TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr3:128292497C>T	uc003ekq.2	-	3	1043	c.76G>A	c.(76-78)GTC>ATC	p.V26I		NM_007354	NP_031380	O15544	GR6_HUMAN	putative GR6 protein	26											0				GBM - Glioblastoma multiforme(114;0.176)		AGGCGGGAGACGCTGAGTCTA	0.592													9	40					0	0	2.17888e-05	0	0
KY	339855	broad.mit.edu	37	3	134323200	134323200	+	Nonsense_Mutation	SNP	C	A	A			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr3:134323200C>A	uc010hty.2	-	11	1269	c.1207G>T	c.(1207-1209)GAG>TAG	p.E403*	KY_uc011blw.1_3'UTR|KY_uc011blx.1_Nonsense_Mutation_p.E382*	NM_178554	NP_848649	Q8NBH2	KY_HUMAN	kyphoscoliosis peptidase	403						cytoskeleton|Z disc	peptidase activity			ovary(2)	2						GGGTACACCTCCAACTTCATC	0.542													83	37					1.44182e-19	9.0741e-18	0.000147903	1	0
HPS3	84343	broad.mit.edu	37	3	148885021	148885021	+	Missense_Mutation	SNP	G	T	T			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr3:148885021G>T	uc003ewu.1	+	15	2930	c.2790G>T	c.(2788-2790)GAG>GAT	p.E930D	CP_uc011bnr.1_Intron|HPS3_uc011bnq.1_Missense_Mutation_p.E765D|HPS3_uc003ewv.1_RNA	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	930						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			TGAAAGAAGAGAACCGGGTAT	0.313									Hermansky-Pudlak_syndrome				23	18					5.26018e-13	3.22669e-11	0.000229342	1	0
CRIPAK	285464	broad.mit.edu	37	4	1388729	1388729	+	Missense_Mutation	SNP	G	C	C			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr4:1388729G>C	uc003gdf.2	+	1	3390	c.430G>C	c.(430-432)GGA>CGA	p.G144R		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	144	3.				ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			GTGCCCATGCGGAGTGCCCGC	0.701													4	173					0	0	0.00024832	0	0
DCHS2	54798	broad.mit.edu	37	4	155256161	155256161	+	Missense_Mutation	SNP	T	G	G			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr4:155256161T>G	uc003inw.2	-	8	1075	c.1075A>C	c.(1075-1077)ATT>CTT	p.I359L	DCHS2_uc003inx.2_Missense_Mutation_p.I858L	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	359	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TCGGCATTAATGACAGCTGTG	0.433													42	44					0	0	0.000147903	0	0
HNRNPAB	3182	broad.mit.edu	37	5	177632984	177632984	+	Silent	SNP	G	A	A			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr5:177632984G>A	uc003miu.2	+	3	608	c.351G>A	c.(349-351)CTG>CTA	p.L117L	HNRNPAB_uc003miv.2_Silent_p.L117L|HNRNPAB_uc010jks.2_Silent_p.L117L|HNRNPAB_uc003miw.2_Silent_p.L117L|HNRNPAB_uc003mix.2_Silent_p.L117L	NM_031266	NP_112556	Q99729	ROAA_HUMAN	heterogeneous nuclear ribonucleoprotein A/B	116	RRM 1.				epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding				0						GGTTTATCCTGTTCAAAGATG	0.408													81	74					0	0	0.000147903	0	0
CCDC90A	63933	broad.mit.edu	37	6	13800602	13800602	+	Missense_Mutation	SNP	C	T	T			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr6:13800602C>T	uc003nbd.2	-	5	882	c.754G>A	c.(754-756)GAA>AAA	p.E252K	CCDC90A_uc010jpf.2_RNA	NM_001031713	NP_001026883	Q96AQ8	CC90A_HUMAN	coiled-coil domain containing 90A precursor	252	Potential.					integral to membrane|mitochondrion					0	Breast(50;0.0027)|Ovarian(93;0.0964)	all_hematologic(90;0.117)				TGATGTAGTTCGAGTTTTATT	0.244													8	10					0	0	1.12685e-05	0	0
MDFI	4188	broad.mit.edu	37	6	41614025	41614025	+	Missense_Mutation	SNP	G	A	A			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr6:41614025G>A	uc003oqp.3	+	4	567	c.238G>A	c.(238-240)GTC>ATC	p.V80I	MDFI_uc003oqq.3_Missense_Mutation_p.V80I|MDFI_uc010jxn.2_Missense_Mutation_p.V80I	NM_005586	NP_005577	Q99750	MDFI_HUMAN	MyoD family inhibitor	80					cytoplasmic sequestering of transcription factor|dorsal/ventral axis specification|negative regulation of DNA binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of Wnt receptor signaling pathway	cytoplasm|nucleus					0	Ovarian(28;0.0327)|Colorectal(47;0.121)		Colorectal(64;0.0123)|COAD - Colon adenocarcinoma(64;0.0264)|KIRC - Kidney renal clear cell carcinoma(1;0.138)			TGACCTCGACGTCCCCACAGA	0.627													15	13					0	0	0.000219431	0	0
ICK	22858	broad.mit.edu	37	6	52878690	52878690	+	Missense_Mutation	SNP	G	C	C			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr6:52878690G>C	uc003pbh.2	-	10	1412	c.922C>G	c.(922-924)CTG>GTG	p.L308V	ICK_uc003pbi.2_Missense_Mutation_p.L308V	NM_016513	NP_057597	Q9UPZ9	ICK_HUMAN	intestinal cell kinase	308					intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			ovary(1)|large_intestine(1)|lung(1)|kidney(1)|central_nervous_system(1)	5	Lung NSC(77;0.103)					GCCTTTTCCAGGATGCCTTTC	0.512													23	18					0	0	0.000229342	0	0
SYNCRIP	10492	broad.mit.edu	37	6	86332283	86332283	+	Missense_Mutation	SNP	C	A	A			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr6:86332283C>A	uc003pla.2	-	8	1466	c.925G>T	c.(925-927)GGT>TGT	p.G309C	SYNCRIP_uc003pku.2_Missense_Mutation_p.G309C|SYNCRIP_uc003pkw.2_Intron|SYNCRIP_uc003pky.2_Missense_Mutation_p.G211C|SYNCRIP_uc003pkv.2_Missense_Mutation_p.G309C|SYNCRIP_uc003pkx.2_Missense_Mutation_p.G157C|SYNCRIP_uc003pkz.2_Intron	NM_006372	NP_006363	O60506	HNRPQ_HUMAN	synaptotagmin binding, cytoplasmic RNA	309	RRM 2.				CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			ovary(2)	2		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		TTGACTTTACCACTCATTAAC	0.428													10	211					3.86212e-05	0.0023106	3.86212e-05	1	0
C6orf35	729515	broad.mit.edu	37	6	157743805	157743806	+	Nonsense_Mutation	DNP	CC	AA	AA	rs113617786	by1000genomes	TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr6:157743805_157743806CC>AA	uc003sih.3	-	2	383_384	c.120_121GG>TT	c.(118-123)GCGGGA>GCTTGA	p.G41*		NM_018452	NP_060922	Q9NWH2	CF035_HUMAN	hypothetical protein LOC729515	41	Helical; (Potential).					integral to membrane					0						GCTAGCATTCCCGCTGCAGCAA	0.386													7	161					0	0	6.4e-05	0	0
INHBA	3624	broad.mit.edu	37	7	41739686	41739687	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr7:41739686_41739687CC>AA	uc003thq.2	-	1	521_522	c.286_287GG>TT	c.(286-288)GGG>TTG	p.G96L	LOC285954_uc003tht.3_Intron|INHBA_uc003thr.2_Missense_Mutation_p.G96L|LOC285954_uc003ths.2_Intron	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	96					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6						CCCGTTCTCCCCGACTTTGCCC	0.515										TSP Lung(11;0.080)			18	812					0	0	6.4e-05	0	0
CCM2	83605	broad.mit.edu	37	7	45112359	45112359	+	Silent	SNP	C	T	T			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr7:45112359C>T	uc003tmo.2	+	7	926	c.780C>T	c.(778-780)ACC>ACT	p.T260T	CCM2_uc003tmn.2_RNA|CCM2_uc003tmp.2_Silent_p.T202T|CCM2_uc003tmq.2_Intron|CCM2_uc003tmr.2_Silent_p.T169T|CCM2_uc011kcc.1_3'UTR|CCM2_uc003tms.2_Silent_p.T281T	NM_031443	NP_113631	Q9BSQ5	CCM2_HUMAN	cerebral cavernous malformation 2 isoform 2	260					endothelial tube morphogenesis|integrin-mediated signaling pathway|stress-activated MAPK cascade|vasculogenesis	cytoplasm	protein binding				0						TTAAGGAGACCTACGAGGTGG	0.507									Familial_Cerebral_Cavernous_Angioma				31	99					0	0	0.000159656	0	0
ZKSCAN5	23660	broad.mit.edu	37	7	99123898	99123898	+	Missense_Mutation	SNP	G	T	T			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr7:99123898G>T	uc003uqv.2	+	6	1359	c.1235G>T	c.(1234-1236)CGG>CTG	p.R412L	ZKSCAN5_uc010lfx.2_Missense_Mutation_p.R412L|ZKSCAN5_uc003uqw.2_Missense_Mutation_p.R412L|ZKSCAN5_uc003uqx.2_Missense_Mutation_p.R339L|ZKSCAN5_uc003uqy.2_Missense_Mutation_p.R148L	NM_145102	NP_659570	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	412	C2H2-type 3.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					AAGGCTTTCCGGGTGAGTTCC	0.582													7	255					8.12818e-05	0.00468919	8.12818e-05	1	0
ZKSCAN1	7586	broad.mit.edu	37	7	99621201	99621201	+	Silent	SNP	A	G	G			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr7:99621201A>G	uc003usk.1	+	2	291	c.72A>G	c.(70-72)GTA>GTG	p.V24V	ZKSCAN1_uc003usj.2_Silent_p.V23V|ZKSCAN1_uc003usl.1_5'UTR|ZKSCAN1_uc003usm.1_Intron	NM_003439	NP_003430	P17029	ZKSC1_HUMAN	zinc finger protein 36	24					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			ATGGTATCGTAATAGTGAAGG	0.542													40	123					0	0	6.26518e-05	0	0
AP4M1	9179	broad.mit.edu	37	7	99701290	99701291	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr7:99701290_99701291CC>AA	uc003utb.3	+	6	726_727	c.518_519CC>AA	c.(517-519)CCC>CAA	p.P173Q	MCM7_uc003usv.1_5'Flank|MCM7_uc003usw.1_5'Flank|MCM7_uc003usx.1_5'Flank|AP4M1_uc011kjg.1_Missense_Mutation_p.P127Q|AP4M1_uc010lgl.1_Missense_Mutation_p.P173Q|AP4M1_uc003utc.3_Missense_Mutation_p.P180Q|AP4M1_uc010lgm.2_Missense_Mutation_p.P45Q|AP4M1_uc003utd.2_Missense_Mutation_p.P173Q|AP4M1_uc011kjh.1_Missense_Mutation_p.P125Q|AP4M1_uc003ute.3_5'UTR|AP4M1_uc003utf.3_Missense_Mutation_p.P45Q	NM_004722	NP_004713	O00189	AP4M1_HUMAN	adaptor-related protein complex 4, mu 1 subunit	173					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|coated pit|Golgi trans cisterna	transporter activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCCAGCCGCCCCGTCCTGTCCA	0.54													9	234					0	0	6.4e-05	0	0
CPA1	1357	broad.mit.edu	37	7	130027736	130027737	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr7:130027736_130027737CG>AT	uc003vpx.2	+	10	1216_1217	c.1144_1145CG>AT	c.(1144-1146)CGG>ATG	p.R382M		NM_001868	NP_001859	P15085	CBPA1_HUMAN	carboxypeptidase A1 precursor	382					proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					CTTCGAGCTCCGGGACACTGGG	0.574													8	506					0	0	6.4e-05	0	0
BRAF	673	broad.mit.edu	37	7	140434425	140434426	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr7:140434425_140434426CC>AA	uc003vwc.3	-	18	2333_2334	c.2272_2273GG>TT	c.(2272-2274)GGG>TTG	p.G758L		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	758					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	ACCATATCCCCCTGCCTGGATG	0.436		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				15	675					0	0	6.4e-05	0	0
Unknown	0	broad.mit.edu	37	7	142499644	142499645	+	RNA	DNP	CG	AT	AT			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr7:142499644_142499645CG>AT	uc003wbe.3	+	3		c.457_458CG>AT			uc003wbf.3_RNA|uc003wbh.3_Nonsense_Mutation_p.E182*|uc003wbi.3_RNA|uc003wbm.3_RNA|uc003wbn.3_RNA|uc010los.2_RNA					Homo sapiens mRNA for T cell receptor V beta14-D-J, partial cds.																		GCTTCACCTCCGGTAAGTGAGT	0.51													11	806					0	0	6.4e-05	0	0
RARRES2	5919	broad.mit.edu	37	7	150037229	150037229	+	Missense_Mutation	SNP	C	A	A			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr7:150037229C>A	uc003wha.2	-	3	356	c.239G>T	c.(238-240)AGG>ATG	p.R80M	RARRES2_uc010lpp.1_Missense_Mutation_p.R80M	NM_002889	NP_002880	Q99969	RARR2_HUMAN	chemerin preproprotein	80					embryonic digestive tract development|in utero embryonic development|positive regulation of macrophage chemotaxis|retinoid metabolic process	extracellular matrix	receptor binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.011)			CTTCCAGTCCCTCTTCCGGCA	0.582													14	751					0.000151284	0.00862499	0.000151284	1	0
SLC4A2	6522	broad.mit.edu	37	7	150769158	150769158	+	Missense_Mutation	SNP	C	A	A			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr7:150769158C>A	uc003wit.3	+	16	2726	c.2470C>A	c.(2470-2472)CAG>AAG	p.Q824K	SLC4A2_uc011kve.1_Missense_Mutation_p.Q815K|SLC4A2_uc003wiu.3_Missense_Mutation_p.Q810K|SLC4A2_uc003wiv.3_Missense_Mutation_p.Q18K	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	824	Membrane (anion exchange).			Q -> R (in Ref. 1; CAA44067 and 6; CAA27556).	bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCGCTTCACCCAGGAGATCTT	0.617													9	295					6.40141e-05	0.0037375	6.40141e-05	1	0
ASB10	136371	broad.mit.edu	37	7	150878302	150878302	+	Silent	SNP	C	G	G			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr7:150878302C>G	uc003wjm.1	-	3	1089	c.963G>C	c.(961-963)CTG>CTC	p.L321L	ASB10_uc003wjl.1_Silent_p.L321L|ASB10_uc003wjn.1_Silent_p.L261L	NM_001142459	NP_001135931	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box-containing 10	276	ANK 5.				intracellular signal transduction						0			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCAAGCTGCACAGCTGCAGGC	0.682													10	42					0	0	2.31682e-05	0	0
WISP1	8840	broad.mit.edu	37	8	134225321	134225321	+	Missense_Mutation	SNP	C	T	T			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr8:134225321C>T	uc003yub.2	+	2	360	c.284C>T	c.(283-285)CCC>CTC	p.P95L	WISP1_uc003yuc.2_Missense_Mutation_p.P95L|WISP1_uc010meb.2_Intron|WISP1_uc010mec.2_Missense_Mutation_p.P95L|WISP1_uc010med.2_Intron|WISP1_uc003yud.2_RNA	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	95	IGFBP N-terminal.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			ATCTGTGACCCCCACCGGGGC	0.612													32	34					0	0	0.000109025	0	0
IFNA16	3449	broad.mit.edu	37	9	21216839	21216840	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr9:21216839_21216840CC>AA	uc003zor.1	-	1	471_472	c.465_466GG>TT	c.(463-468)ATGGGG>ATTTGG	p.155_156MG>IW	IFNA14_uc003zoo.1_Intron	NM_002173	NP_002164	P05015	IFN16_HUMAN	interferon, alpha 16 precursor	155_156					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			skin(1)	1				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		TATTTCTTCCCCATCAGATAAA	0.446													9	272					0	0	6.4e-05	0	0
COL27A1	85301	broad.mit.edu	37	9	117047026	117047026	+	Missense_Mutation	SNP	C	G	G			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr9:117047026C>G	uc011lxl.1	+	41	3956	c.3956C>G	c.(3955-3957)CCC>CGC	p.P1319R	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1319	Collagen-like 12.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						ATTGTGGGACCCCTTGGACCT	0.478													30	49					0	0	5.84002e-05	0	0
TMEM203	94107	broad.mit.edu	37	9	140099503	140099503	+	Missense_Mutation	SNP	A	T	T			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr9:140099503A>T	uc004clv.2	-	1	588	c.364T>A	c.(364-366)TTC>ATC	p.F122I	NDOR1_uc004clx.2_5'Flank|NDOR1_uc004clw.2_5'Flank|NDOR1_uc011mes.1_5'Flank|NDOR1_uc004cly.2_5'Flank	NM_053045	NP_444273	Q969S6	TM203_HUMAN	transmembrane protein 203	122	Helical; (Potential).					integral to membrane					0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		AGGAGAATGAAGAGCGGGGAC	0.587													19	16					0	0	3.10358e-05	0	0
LOC442459	442459	broad.mit.edu	37	X	98975171	98975171	+	RNA	SNP	C	T	T			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chrX:98975171C>T	uc011mrd.1	-	8		c.1172G>A				NR_024608				Homo sapiens DNA repair protein mRNA, complete cds.												0						CTTCTGTTTCCTCTTTCTCCA	0.453													12	3					0	0	0.00010058	0	0
ARID4A	5926	broad.mit.edu	37	14	58827698	58827698	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr14:58827698delC	uc001xdp.2	+	19	2272	c.2018delC	c.(2017-2019)TCAfs	p.S673fs	ARID4A_uc001xdo.2_Frame_Shift_Del_p.S673fs|ARID4A_uc001xdq.2_Frame_Shift_Del_p.S673fs|ARID4A_uc010apg.1_Frame_Shift_Del_p.S351fs	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	673					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						CCTTTAAAATCAACCCTCTCA	0.433													59	73	---	---	---	---					
C2orf55	343990	broad.mit.edu	37	2	99413866	99413867	+	Frame_Shift_Del	DEL	GT	-	-			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr2:99413866_99413867delGT	uc002szf.1	-	8	2844_2845	c.2550_2551delAC	c.(2548-2553)GCACGGfs	p.A850fs		NM_207362	NP_997245	Q6NV74	CB055_HUMAN	hypothetical protein LOC343990	850_851											0						TTCAGGGTCCGTGCCCCAGGCT	0.619													42	61	---	---	---	---					
HIP1	3092	broad.mit.edu	37	7	75168684	75168684	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr7:75168684delT	uc003uds.1	-	30	3061	c.3020delA	c.(3019-3021)AAGfs	p.K1007fs	HIP1_uc011kfz.1_Frame_Shift_Del_p.K833fs	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	1007	I/LWEQ.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						CTCGTAGTGCTTTTTCCGAAG	0.507			T	PDGFRB	CMML								8	834	---	---	---	---					
PDK4	5166	broad.mit.edu	37	7	95221864	95221872	+	In_Frame_Del	DEL	CCAATGTGG	-	-	rs138077797		TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chr7:95221864_95221872delCCAATGTGG	uc003uoa.2	-	5	887_895	c.567_575delCCACATTGG	c.(565-576)AGCCACATTGGA>AGA	p.189_192SHIG>R	PDK4_uc003unz.2_5'UTR	NM_002612	NP_002603	Q16654	PDK4_HUMAN	pyruvate dehydrogenase kinase 4 precursor	189_192	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity				0	all_cancers(62;1.06e-10)|all_epithelial(64;1.04e-09)|Lung NSC(181;0.128)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0151)			ATCAATGCTTCCAATGTGGCTTGGGTTTC	0.321													78	127	---	---	---	---					
KDM6A	7403	broad.mit.edu	37	X	44920581	44920581	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chrX:44920581delA	uc004dge.3	+	14	1717	c.1342delA	c.(1342-1344)AATfs	p.N448fs	KDM6A_uc010nhk.2_Frame_Shift_Del_p.N448fs|KDM6A_uc011mkz.1_Frame_Shift_Del_p.N500fs|KDM6A_uc011mla.1_Frame_Shift_Del_p.N403fs|KDM6A_uc011mlb.1_Frame_Shift_Del_p.N455fs|KDM6A_uc011mlc.1_Frame_Shift_Del_p.N152fs|KDM6A_uc011mld.1_Frame_Shift_Del_p.N121fs	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	448					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TACTTCTGACAATTGGAGTGG	0.348			D|N|F|S		renal|oesophageal SCC|MM								14	1	---	---	---	---					
EMD	2010	broad.mit.edu	37	X	153609241	153609241	+	Splice_Site	DEL	G	-	-			TCGA-HE-7129-01A-11D-1961-08	TCGA-HE-7129-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	c56f3efb-5a25-4967-b817-44b1eb9f440a	3c6e3907-3f31-4a91-825b-87070d603395	g.chrX:153609241delG	uc004fkl.2	+	6	698	c.450_splice	c.e6-1	p.R150_splice		NM_000117	NP_000108	P50402	EMD_HUMAN	emerin						cellular response to growth factor stimulus|muscle contraction|muscle organ development|negative regulation of catenin import into nucleus|negative regulation of fibroblast proliferation|positive regulation of protein export from nucleus|regulation of canonical Wnt receptor signaling pathway	endoplasmic reticulum|integral to membrane|microtubule|nuclear inner membrane|nuclear outer membrane	actin binding|beta-tubulin binding				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TTTTGCCTCAGGGAACGCCCC	0.622													40	5	---	---	---	---					
