Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CDK11A	728642	broad.mit.edu	37	1	1638914	1638914	+	Silent	SNP	G	T	T			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr1:1638914G>T	uc009vks.2	-	11	1287	c.1179C>A	c.(1177-1179)CCC>CCA	p.P393P	CDK11B_uc001ags.1_Intron|CDK11B_uc001agt.1_Intron|CDK11B_uc001aha.1_Intron|CDK11B_uc001agw.1_Intron|CDK11B_uc001agv.1_Intron|CDK11B_uc001agy.1_Intron|CDK11B_uc001agx.1_Intron|CDK11B_uc001agz.1_Intron|SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Intron|CDK11A_uc001ahj.3_5'UTR|CDK11A_uc009vkp.2_Intron|CDK11A_uc009vkq.2_Intron|CDK11A_uc009vkr.2_Silent_p.P383P|CDK11A_uc010nys.1_Silent_p.P383P|CDK11A_uc010nyt.1_Silent_p.P393P|CDK11A_uc010nyu.1_RNA	NM_024011	NP_076916	Q9UQ88	CD11A_HUMAN	cell division cycle 2-like 2 isoform 1	396					apoptosis|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			stomach(1)	1						CAGGGGAGTCGGGCACATAGT	0.672000													13	10					0.000219431	0.00401377	0.000219431	1	0
NPHP4	261734	broad.mit.edu	37	1	5935029	5935029	+	Silent	SNP	G	A	A			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr1:5935029G>A	uc001alq.1	-	21	3215	c.2949C>T	c.(2947-2949)GCC>GCT	p.A983A		NM_015102	NP_055917	O75161	NPHP4_HUMAN	nephroretinin	983					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			pancreas(1)	1	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		CCCCCAGCGTGGCGTGGAGCG	0.627000													6	51					0	0	0.00116845	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	T	T			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr1:16918653C>T	uc009vos.1	-	6	853	c.-35_splice	c.e6+1		NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672							cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													4	46					0	0	0.000602214	0	0
RPS6KA1	6195	broad.mit.edu	37	1	26885310	26885310	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr1:26885310T>C	uc001bmr.1	+	14	1260	c.1097T>C	c.(1096-1098)ATC>ACC	p.I366T	RPS6KA1_uc010ofe.1_Missense_Mutation_p.I274T|RPS6KA1_uc010off.1_Missense_Mutation_p.I350T|RPS6KA1_uc001bms.1_Missense_Mutation_p.I375T|RPS6KA1_uc009vsl.1_Missense_Mutation_p.I209T	NM_002953	NP_002944	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	366	AGC-kinase C-terminal.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		TCCCCAGGCATCCCCCCCAGC	0.672000													3	76					0	0	0.000602214	0	0
CGN	57530	broad.mit.edu	37	1	151509762	151509762	+	Silent	SNP	C	T	T			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr1:151509762C>T	uc009wmw.2	+	21	3696	c.3552C>T	c.(3550-3552)TAC>TAT	p.Y1184Y	CGN_uc010pde.1_Silent_p.Y178Y	NM_020770	NP_065821	Q9P2M7	CING_HUMAN	cingulin	1178	Tail.					myosin complex|tight junction	actin binding|motor activity			ovary(2)|pancreas(1)	3	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			ACAGTGTCTACGATCCCTCGT	0.537000													16	42					0	0	0.000566183	0	0
ADAR	103	broad.mit.edu	37	1	154562826	154562826	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr1:154562826T>C	uc001ffh.2	-	7	2530	c.2330A>G	c.(2329-2331)AAG>AGG	p.K777R	ADAR_uc001ffj.2_Missense_Mutation_p.K758R|ADAR_uc001ffi.2_Missense_Mutation_p.K777R|ADAR_uc001ffk.2_Missense_Mutation_p.K482R	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	777	DRBM 3.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		GCCTTGCTTCTTGCTGTGTGC	0.542000													20	86					0	0	0.00152264	0	0
CACNA1S	779	broad.mit.edu	37	1	201034981	201034981	+	Silent	SNP	G	T	T			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr1:201034981G>T	uc001gvv.2	-	22	3065	c.2838C>A	c.(2836-2838)GGC>GGA	p.G946G		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	946	Helical; Name=S5 of repeat III; (Potential).|III.				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	AGAGCTGGACGCCGATGCAGG	0.622000													10	16					0.000442599	0.00793066	0.000442599	1	0
SVIL	6840	broad.mit.edu	37	10	29811367	29811367	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr10:29811367G>C	uc001iut.1	-	16	4114	c.3361C>G	c.(3361-3363)CCC>GCC	p.P1121A	SVIL_uc010qdw.1_Missense_Mutation_p.P19A|SVIL_uc001iuu.1_Missense_Mutation_p.P695A	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1121					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				GTTTTGCTGGGTGAGTCAAGA	0.468000													24	53					0	0	0.00047179	0	0
PARD3	56288	broad.mit.edu	37	10	34648076	34648076	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr10:34648076T>C	uc010qej.1	-	14	2066	c.2066A>G	c.(2065-2067)GAG>GGG	p.E689G	PARD3_uc010qek.1_Missense_Mutation_p.E689G|PARD3_uc010qel.1_Missense_Mutation_p.E689G|PARD3_uc010qem.1_Missense_Mutation_p.E676G|PARD3_uc010qen.1_Missense_Mutation_p.E676G|PARD3_uc010qeo.1_Missense_Mutation_p.E676G|PARD3_uc010qep.1_Missense_Mutation_p.E632G|PARD3_uc010qeq.1_Missense_Mutation_p.E632G|PARD3_uc001ixo.1_Missense_Mutation_p.E406G|PARD3_uc001ixp.1_Missense_Mutation_p.E554G|PARD3_uc001ixq.1_Missense_Mutation_p.E676G|PARD3_uc001ixr.1_Missense_Mutation_p.E689G|PARD3_uc001ixt.1_Missense_Mutation_p.E510G|PARD3_uc001ixu.1_Missense_Mutation_p.E632G|PARD3_uc001ixs.1_Missense_Mutation_p.E342G	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	689					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				ATTTCTTACCTCATTGCACTT	0.378000													36	94					0	0	0.000953801	0	0
TMEM26	219623	broad.mit.edu	37	10	63212836	63212836	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr10:63212836C>T	uc001jlo.2	-	1	373	c.4G>A	c.(4-6)GAG>AAG	p.E2K	TMEM26_uc010qij.1_RNA|TMEM26_uc001jlq.2_RNA|uc001jlr.2_RNA	NM_178505	NP_848600	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26	2						integral to membrane					0	Prostate(12;0.0112)					ACCAGTCCCTCCATGCTGGCC	0.667000													24	41					0	0	0.000586117	0	0
DNAJB12	54788	broad.mit.edu	37	10	74100871	74100871	+	Missense_Mutation	SNP	T	A	A			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr10:74100871T>A	uc010qjv.1	-	4	767	c.617A>T	c.(616-618)CAG>CTG	p.Q206L	DNAJB12_uc001jsz.2_Missense_Mutation_p.Q206L|DNAJB12_uc001jta.2_Missense_Mutation_p.Q206L	NM_017626	NP_060096	Q9NXW2	DJB12_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 12	172	J.				protein folding	endoplasmic reticulum|integral to membrane	heat shock protein binding|unfolded protein binding				0						ATCGCCGAACTGGTCATACTG	0.602000													18	38					0	0	0.00188189	0	0
CTSD	1509	broad.mit.edu	37	11	1776167	1776167	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr11:1776167G>A	uc001luc.1	-	6	929	c.796C>T	c.(796-798)CGC>TGC	p.R266C	CTSD_uc009yda.1_RNA	NM_001909	NP_001900	P07339	CATD_HUMAN	cathepsin D preproprotein	266					cell death|proteolysis	extracellular space|lysosome|melanosome	aspartic-type endopeptidase activity				0		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TAGGCCTTGCGGGTGACATTC	0.627000													28	61					0	0	0.00127121	0	0
NRXN2	9379	broad.mit.edu	37	11	64453122	64453122	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr11:64453122C>T	uc001oar.2	-	7	1587	c.1148G>A	c.(1147-1149)CGC>CAC	p.R383H	NRXN2_uc001oas.2_Missense_Mutation_p.R359H|NRXN2_uc001oaq.2_Missense_Mutation_p.R57H	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	203	Extracellular (Potential).|Laminin G-like.				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						TCCTACCTGGCGCAGGTTTCG	0.602000													30	61					0	0	0.00178596	0	0
ROBO4	54538	broad.mit.edu	37	11	124765531	124765531	+	Silent	SNP	G	A	A			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr11:124765531G>A	uc001qbg.2	-	6	998	c.858C>T	c.(856-858)ACC>ACT	p.T286T	ROBO4_uc010sas.1_Silent_p.T141T|ROBO4_uc001qbh.2_Silent_p.T176T|ROBO4_uc001qbi.2_5'Flank|ROBO4_uc010sat.1_5'Flank	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	286	Fibronectin type-III 1.				angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		GGGCAGTCTGGGTCCTGAACA	0.672000													28	66					0	0	0.000409698	0	0
LRP6	4040	broad.mit.edu	37	12	12334210	12334210	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr12:12334210T>G	uc001rah.3	-	6	1282	c.1140A>C	c.(1138-1140)GAA>GAC	p.E380D	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.E380D	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	380	LDL-receptor class B 6.|Extracellular (Potential).|Beta-propeller 2.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				TGGCCCTCACTTCATCATCAG	0.463000													54	89					0	0	0.000781405	0	0
CAND1	55832	broad.mit.edu	37	12	67691215	67691215	+	Missense_Mutation	SNP	C	A	A			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr12:67691215C>A	uc001stn.2	+	5	957	c.520C>A	c.(520-522)CCT>ACT	p.P174T	CAND1_uc001sto.2_5'Flank	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	174	HEAT 5.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		TAATTTCCATCCTTCAATTCT	0.408000													31	98					2.85442e-18	5.44821e-17	0.000339439	1	0
CIT	11113	broad.mit.edu	37	12	120150415	120150415	+	Silent	SNP	G	C	C	rs147828404		TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr12:120150415G>C	uc001txi.1	-	35	4592	c.4539C>G	c.(4537-4539)CTC>CTG	p.L1513L	CIT_uc001txh.1_Silent_p.L1032L|CIT_uc001txj.1_Silent_p.L1555L	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1513	PH.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CTGTATTTGCGAGTTCGGAAG	0.592000													3	68					0	0	0.00024832	0	0
CHD8	57680	broad.mit.edu	37	14	21862588	21862588	+	Missense_Mutation	SNP	T	A	A			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr14:21862588T>A	uc001was.1	-	31	4704	c.4610A>T	c.(4609-4611)GAA>GTA	p.E1537V	CHD8_uc001war.1_Missense_Mutation_p.E1433V|SNORD9_uc001wat.1_5'Flank	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1816					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		AGGGTCATATTCCACACCAAA	0.438000													8	17					0	0	0.000274275	0	0
NR2F2	7026	broad.mit.edu	37	15	96875635	96875635	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr15:96875635A>G	uc010uri.1	+	1	1525	c.301A>G	c.(301-303)AGC>GGC	p.S101G	NR2F2_uc002btp.2_Intron|NR2F2_uc010urj.1_5'Flank|MIR1469_hsa-mir-1469|MI0007074_5'Flank|NR2F2_uc010urk.1_5'Flank	NM_021005	NP_066285	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	101	Nuclear receptor.				lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(1)	3	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)			GGGCTGCAAGAGCTTCTTCAA	0.612000													11	19					0	0	0.000978159	0	0
CAMKK1	84254	broad.mit.edu	37	17	3788981	3788981	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr17:3788981T>C	uc002fwt.2	-	2	95	c.1A>G	c.(1-3)ATG>GTG	p.M1V	CAMKK1_uc002fwu.2_Missense_Mutation_p.M1V|CAMKK1_uc002fwv.2_Missense_Mutation_p.M1V	NM_172206	NP_757343	Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase 1	1					synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		CCCCCCTCCATTGCTTCAGTC	0.582000													14	63					0	0	0.000422831	0	0
MYBBP1A	10514	broad.mit.edu	37	17	4451584	4451584	+	Silent	SNP	C	T	T			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr17:4451584C>T	uc002fyb.3	-	12	1640	c.1578G>A	c.(1576-1578)ACG>ACA	p.T526T	MYBBP1A_uc002fxz.3_Silent_p.T526T	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	526	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						GCTTGAACTGCGTGCTGAGGG	0.637000													86	75					0	0	0.000781405	0	0
KRT40	125115	broad.mit.edu	37	17	39140321	39140321	+	Missense_Mutation	SNP	T	A	A			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr17:39140321T>A	uc010cxh.1	-	3	366	c.205A>T	c.(205-207)AAT>TAT	p.N69Y	KRT40_uc002hvq.1_RNA	NM_182497	NP_872303	Q6A162	K1C40_HUMAN	type I hair keratin KA36	69	Head.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)				CAGGGACTATTACAACTCCCA	0.547000													101	88					0	0	0.000781405	0	0
ADAM11	4185	broad.mit.edu	37	17	42855164	42855164	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr17:42855164C>G	uc002ihh.2	+	23	2003	c.2003C>G	c.(2002-2004)CCA>CGA	p.P668R	ADAM11_uc010wjd.1_Missense_Mutation_p.P468R|ADAM11_uc002ihi.2_Missense_Mutation_p.Q21E	NM_002390	NP_002381	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11 preproprotein	668	Cys-rich.|Extracellular (Potential).				integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			pancreas(1)	1		Prostate(33;0.0959)				CGCTGCCTGCCAGCTTCTGCC	0.657000													47	23					0	0	0.000589545	0	0
GPRC5C	55890	broad.mit.edu	37	17	72436053	72436053	+	Silent	SNP	T	A	A			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr17:72436053T>A	uc002jks.2	+	1	177	c.138T>A	c.(136-138)TCT>TCA	p.S46S	GPRC5C_uc002jkp.2_Silent_p.S91S|GPRC5C_uc002jkq.2_Silent_p.S91S|GPRC5C_uc002jkr.2_Silent_p.S58S|GPRC5C_uc002jkt.2_Silent_p.S46S	NM_018653	NP_061123	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor family C, group 5,	46	Extracellular (Potential).					cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			ovary(2)|prostate(1)|central_nervous_system(1)|pancreas(1)	5						GTGACCGCTCTGGGGCGTGGG	0.662000													79	65					0	0	0.000781405	0	0
LOC644669	644669	broad.mit.edu	37	18	15323336	15323336	+	RNA	SNP	G	A	A			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr18:15323336G>A	uc002ktd.1	-	3		c.123C>T				NR_027417				Homo sapiens cDNA FLJ40312 fis, clone TESTI2029880.												0						TTTCCTTATGGCCAATAAAAG	0.289000													4	14					0	0	0.00116845	0	0
FZR1	51343	broad.mit.edu	37	19	3525916	3525916	+	Silent	SNP	G	A	A			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr19:3525916G>A	uc010dtk.2	+	2	154	c.120G>A	c.(118-120)TCG>TCA	p.S40S	FZR1_uc002lxt.2_Silent_p.S40S|FZR1_uc002lxv.2_Silent_p.S40S	NM_001136198	NP_001129670	Q9UM11	FZR_HUMAN	Fzr1 protein isoform 1	40				S->A: Constitutively active; when associated with A-121; A-151 and A-163.	activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|DNA repair|G2/M transition DNA damage checkpoint|mitosis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding			lung(1)|kidney(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGTGTCCTCGCCCAGCAAGC	0.647000													11	25					0	0	0.000673444	0	0
CEACAM5	1048	broad.mit.edu	37	19	42224098	42224098	+	Missense_Mutation	SNP	G	A	A	rs146319665		TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr19:42224098G>A	uc002ork.2	+	7	1863	c.1742G>A	c.(1741-1743)CGC>CAC	p.R581H	CEACAM5_uc002orj.1_Missense_Mutation_p.R580H|CEACAM5_uc002orl.2_Missense_Mutation_p.R581H	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	581	Ig-like 6.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		AGTGCAAACCGCAGTGACCCA	0.517000													53	96					0	0	0.000781405	0	0
DCTN1	1639	broad.mit.edu	37	2	74604848	74604848	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr2:74604848C>G	uc002skx.2	-	3	596	c.285G>C	c.(283-285)CAG>CAC	p.Q95H	DCTN1_uc002skv.2_5'Flank|DCTN1_uc002sku.2_5'Flank|DCTN1_uc002skw.1_Missense_Mutation_p.Q78H|DCTN1_uc010ffd.2_Missense_Mutation_p.Q95H|DCTN1_uc002sky.2_Missense_Mutation_p.Q78H	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	95					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5						CTTCAAATACCTGGATCTGAG	0.458000													3	101					0	0	6.4e-05	0	0
C20orf3	57136	broad.mit.edu	37	20	24944513	24944513	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr20:24944513C>T	uc002wty.2	-	9	1288	c.1187G>A	c.(1186-1188)GGG>GAG	p.G396E	C20orf3_uc002wtz.2_Missense_Mutation_p.G404E|C20orf3_uc010zsw.1_3'UTR	NM_020531	NP_065392	Q9HDC9	APMAP_HUMAN	chromosome 20 open reading frame 3	396	Extracellular (Potential).				biosynthetic process	cell surface|integral to membrane	arylesterase activity|strictosidine synthase activity			ovary(1)	1						GTACAGGTGCCCATCGTGTTC	0.627000													18	108					0	0	0.00074312	0	0
NCOA3	8202	broad.mit.edu	37	20	46254125	46254125	+	Missense_Mutation	SNP	G	T	T			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr20:46254125G>T	uc002xtk.2	+	5	462	c.257G>T	c.(256-258)GGA>GTA	p.G86V	NCOA3_uc010ght.1_Missense_Mutation_p.G86V|NCOA3_uc002xtl.2_Missense_Mutation_p.G86V|NCOA3_uc002xtm.2_Missense_Mutation_p.G86V|NCOA3_uc002xtn.2_Missense_Mutation_p.G86V|NCOA3_uc010zyc.1_5'Flank	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	86					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						GTCTTTTCAGGAAAAACTATT	0.378000													36	48					9.62906e-15	1.79879e-13	0.00128727	1	0
DSCAM	1826	broad.mit.edu	37	21	41459172	41459172	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr21:41459172G>A	uc002yyq.1	-	22	4345	c.3893C>T	c.(3892-3894)CCA>CTA	p.P1298L	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1298	Extracellular (Potential).|Ig-like C2-type 10.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TTTCATCCATGGAGTAGTCAC	0.488000													12	94					0	0	0.00185496	0	0
SNAP29	9342	broad.mit.edu	37	22	21237785	21237785	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr22:21237785G>C	uc011ahw.1	+	4	654	c.547G>C	c.(547-549)GCC>CCC	p.A183P		NM_004782	NP_004773	O95721	SNP29_HUMAN	synaptosomal-associated protein 29	183					cellular membrane fusion|exocytosis|protein transport|vesicle targeting	cell junction|cytoplasm|nucleus|synapse|synaptosome	SNAP receptor activity				0	all_cancers(11;2.77e-25)|all_epithelial(7;8.92e-24)|Lung NSC(8;1.49e-15)|all_lung(8;2.54e-14)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000592)|Lung(15;0.0117)			GGCTGGTTCTGCCATGAGTAC	0.498000													78	186					0	0	0.000781405	0	0
KIAA1407	57577	broad.mit.edu	37	3	113724781	113724781	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr3:113724781T>C	uc003eax.2	-	10	1589	c.1442A>G	c.(1441-1443)AAG>AGG	p.K481R	KIAA1407_uc011bin.1_RNA|KIAA1407_uc011bio.1_Missense_Mutation_p.K459R|KIAA1407_uc011bip.1_Missense_Mutation_p.K468R	NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	481										ovary(2)	2						CAAGGGAGGCTTTTCCCACAA	0.478000													3	150					0	0	0.00024832	0	0
HPS3	84343	broad.mit.edu	37	3	148872995	148872995	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr3:148872995A>G	uc003ewu.1	+	8	1642	c.1502A>G	c.(1501-1503)AAA>AGA	p.K501R	HPS3_uc011bnq.1_Missense_Mutation_p.K336R	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	501						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			CAGCTGTACAAAGAGATGGTA	0.348000									Hermansky-Pudlak_syndrome				26	57					0	0	0.000720815	0	0
RBM47	54502	broad.mit.edu	37	4	40440532	40440532	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr4:40440532C>G	uc003gvc.2	-	4	1089	c.379G>C	c.(379-381)GCA>CCA	p.A127P	RBM47_uc003gvd.2_Missense_Mutation_p.A127P|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Missense_Mutation_p.A89P|RBM47_uc003gvg.1_Missense_Mutation_p.A127P	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	127	RRM 1.					nucleus	nucleotide binding|RNA binding			breast(3)	3						TCACGCACTGCGCGCTTGGCC	0.642000													6	43					0	0	8.12818e-05	0	0
C4orf37	285555	broad.mit.edu	37	4	98633942	98633942	+	Missense_Mutation	SNP	A	T	T			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr4:98633942A>T	uc003htt.1	-	10	1318	c.1228T>A	c.(1228-1230)TTA>ATA	p.L410I		NM_174952	NP_777612	Q8N412	CD037_HUMAN	hypothetical protein LOC285555	410											0				OV - Ovarian serous cystadenocarcinoma(123;2.27e-08)		GATTTCCTTAAAACAGGATTG	0.348000													31	56					0	0	0.00058488	0	0
DMXL1	1657	broad.mit.edu	37	5	118525502	118525502	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr5:118525502C>G	uc003ksd.2	+	29	7416	c.7235C>G	c.(7234-7236)CCA>CGA	p.P2412R	DMXL1_uc010jcl.1_Missense_Mutation_p.P2412R	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2412										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TCCTCGGCACCAGTAAGCCAG	0.438000													36	90					0	0	0.000953801	0	0
RAB24	53917	broad.mit.edu	37	5	176729807	176729807	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr5:176729807C>G	uc003mfv.2	-	4	580	c.211G>C	c.(211-213)GAG>CAG	p.E71Q	RAB24_uc003mfu.2_Missense_Mutation_p.E42Q|RAB24_uc003mfw.2_Missense_Mutation_p.E71Q|PRELID1_uc003mfx.2_5'Flank|PRELID1_uc003mfy.2_5'Flank	NM_130781	NP_570137	Q969Q5	RAB24_HUMAN	RAB24 gene product	71					autophagy|protein transport|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|protein binding				0	all_cancers(89;2.49e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTCATGGCCTCATAGCGCTCA	0.537000													3	70					0	0	0.00024832	0	0
KIAA0319	9856	broad.mit.edu	37	6	24578370	24578370	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr6:24578370C>G	uc011djo.1	-	9	1710	c.1473G>C	c.(1471-1473)TTG>TTC	p.L491F	KIAA0319_uc011djp.1_Missense_Mutation_p.L446F|KIAA0319_uc003neh.1_Missense_Mutation_p.L491F|KIAA0319_uc011djq.1_Missense_Mutation_p.L482F|KIAA0319_uc011djr.1_Missense_Mutation_p.L491F|KIAA0319_uc010jpt.1_5'UTR	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	491	PKD 2.|Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						CAAGGTTAGACAAGCGTAAGA	0.408000													39	73					0	0	0.00111076	0	0
DNAH11	8701	broad.mit.edu	37	7	21737744	21737744	+	Silent	SNP	A	G	G			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr7:21737744A>G	uc003svc.2	+	37	6145	c.6114A>G	c.(6112-6114)TTA>TTG	p.L2038L		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2038	AAA 1 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AAATCTTGTTAGTTGCTGAAG	0.423000									Kartagener_syndrome				34	35					0	0	0.000692331	0	0
TLN1	7094	broad.mit.edu	37	9	35703618	35703618	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr9:35703618T>C	uc003zxt.2	-	48	6767	c.6413A>G	c.(6412-6414)GAG>GGG	p.E2138G		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	2138					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TTTGGTGGCCTCATCTTCCAC	0.527000													3	67					0	0	6.4e-05	0	0
SCARNA2	677766	broad.mit.edu	37	1	109642945	109642945	+	RNA	DEL	G	-	-			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr1:109642945delG	uc001dwo.1	+	1		c.131delG				NR_003023				Homo sapiens cDNA clone IMAGE:6602628, partial cds.												0						GAGCGTGTTAGGCGAGTGCGT	0.647													18	44	---	---	---	---					
C11orf84	144097	broad.mit.edu	37	11	63594447	63594448	+	Frame_Shift_Del	DEL	GT	-	-			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr11:63594447_63594448delGT	uc001nxt.2	+	6	1218_1219	c.982_983delGT	c.(982-984)GTGfs	p.V328fs	C11orf84_uc001nxu.1_RNA	NM_138471	NP_612480	Q9BUA3	CK084_HUMAN	hypothetical protein LOC144097	328											0						GGTTATCCGCGTGCGGATGGAG	0.683													7	18	---	---	---	---					
RSPRY1	89970	broad.mit.edu	37	16	57261323	57261323	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr16:57261323delA	uc002elb.2	+	11	1509	c.1231delA	c.(1231-1233)AATfs	p.N411fs	RSPRY1_uc002elc.2_Frame_Shift_Del_p.N411fs|RSPRY1_uc002eld.2_Frame_Shift_Del_p.N411fs	NM_133368	NP_588609	Q96DX4	RSPRY_HUMAN	ring finger and SPRY domain containing 1	411	B30.2/SPRY.					extracellular region	zinc ion binding			ovary(1)	1						GATTTGGTACAATGCCAGAAG	0.453													54	45	---	---	---	---					
ALS2CR4	65062	broad.mit.edu	37	2	202493983	202493983	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr2:202493983delA	uc002uyh.1	-	10	940	c.839delT	c.(838-840)TTGfs	p.L280fs	ALS2CR4_uc002uyg.1_Frame_Shift_Del_p.L272fs|ALS2CR4_uc010zho.1_Frame_Shift_Del_p.L75fs|ALS2CR4_uc010zhp.1_RNA	NM_001044385	NP_001037850	Q96Q45	TM237_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	304	Helical; (Potential).					integral to membrane	protein binding				0						ACTCAGAGCCAAAAGCAAGTA	0.428													8	22	---	---	---	---					
BACH1	571	broad.mit.edu	37	21	30698866	30698866	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr21:30698866delA	uc002ynj.2	+	3	836	c.721delA	c.(721-723)ACTfs	p.T241fs	BACH1_uc002ynk.2_Frame_Shift_Del_p.T241fs|BACH1_uc002ynl.2_RNA	NM_001186	NP_001177	O14867	BACH1_HUMAN	BTB and CNC homology 1 transcription factor	241						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|liver(1)	2						CAGAGTCCGTACTGGGGAATC	0.453													38	77	---	---	---	---					
CCR3	1232	broad.mit.edu	37	3	46306948	46306948	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr3:46306948delT	uc003cpg.1	+	4	842	c.299delT	c.(298-300)GTTfs	p.V100fs	CCR3_uc003cpi.1_Frame_Shift_Del_p.V100fs|CCR3_uc003cpj.1_Frame_Shift_Del_p.V100fs|CCR3_uc003cpk.1_Frame_Shift_Del_p.V121fs|CCR3_uc010hjb.1_Frame_Shift_Del_p.V118fs|CCR3_uc003cpl.1_Frame_Shift_Del_p.V133fs	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	100	Extracellular (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		CATAACTGGGTTTTTGGCCAT	0.488													7	444	---	---	---	---					
RUNX2	860	broad.mit.edu	37	6	45390446	45390448	+	In_Frame_Del	DEL	CAG	-	-			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr6:45390446_45390448delCAG	uc011dvx.1	+	3	385_387	c.175_177delCAG	c.(175-177)CAGdel	p.Q71del	RUNX2_uc011dvy.1_In_Frame_Del_p.Q71del|RUNX2_uc003oxt.2_In_Frame_Del_p.Q57del	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	71	Poly-Gln.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						gcagcagcaacagcagcagcagc	0.276													7	77	---	---	---	---					
FGL2	10875	broad.mit.edu	37	7	76828725	76828726	+	Frame_Shift_Ins	INS	-	T	T			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr7:76828725_76828726insT	uc003ugb.2	-	1	425_426	c.385_386insA	c.(385-387)AGAfs	p.R129fs	CCDC146_uc003ufz.1_Intron|CCDC146_uc003uga.2_Intron	NM_006682	NP_006673	Q14314	FGL2_HUMAN	fibrinogen-like 2 precursor	129	Potential.				signal transduction	fibrinogen complex	receptor binding			skin(2)	2						TTCTCTAACTCTGTTATCACCA	0.495													33	135	---	---	---	---					
MYST3	7994	broad.mit.edu	37	8	41836161	41836161	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr8:41836161delC	uc010lxb.2	-	7	1586	c.1042delG	c.(1042-1044)GTAfs	p.V348fs	MYST3_uc010lxc.2_Frame_Shift_Del_p.V348fs|MYST3_uc003xon.3_Frame_Shift_Del_p.V348fs|MYST3_uc010lxd.2_Frame_Shift_Del_p.V348fs	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	348	Interaction with RUNX1-1.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			ACAACTTACACCGTGTTTTGT	0.383													105	278	---	---	---	---					
CNTLN	54875	broad.mit.edu	37	9	17462949	17462949	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chr9:17462949delT	uc003zmz.2	+	20	3365	c.3339delT	c.(3337-3339)AATfs	p.N1113fs	CNTLN_uc003zmy.2_Frame_Shift_Del_p.N1114fs|CNTLN_uc010mio.2_Frame_Shift_Del_p.N793fs	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	1114	Potential.					centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		AGTCATCAAATGTGAAGACTT	0.294													29	69	---	---	---	---					
Unknown	0	broad.mit.edu	37	M	310	311	+	Splice_Site	INS	-	C	C			TCGA-BQ-7046-01A-11D-1961-08	TCGA-BQ-7046-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa8122c-c3e4-4e48-a47a-82feb79f1dc0	ea85b7f0-e214-4d27-80c1-c254338b6b0c	g.chrM:310_311insC	uc004coq.3	-	1		c.56_splice	c.e1+1		uc004cor.1_5'Flank|uc004cos.3_5'Flank					Homo sapiens cDNA: FLJ22857 fis, clone KAT01615.																		AAACCCCCCCCTCCCCCCGCTT	0.411													5	3	---	---	---	---					
