Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RPL22	6146	broad.mit.edu	37	1	6246873	6246873	+	Nonsense_Mutation	SNP	A	T	T			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr1:6246873A>T	uc001amd.2	-	4	292	c.246T>A	c.(244-246)TAT>TAA	p.Y82*	RPL22_uc001ame.2_Missense_Mutation_p.F77I	NM_000983	NP_000974	P35268	RL22_HUMAN	ribosomal protein L22 proprotein	82					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	heparin binding|RNA binding|structural constituent of ribosome				0	Ovarian(185;0.0634)	all_cancers(23;2.78e-38)|all_epithelial(116;8.88e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.53e-38)|GBM - Glioblastoma multiforme(13;3.33e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.8e-19)|Colorectal(212;6.8e-08)|COAD - Colon adenocarcinoma(227;8.04e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		GATATTTCAAATACCTGCAGA	0.358000			T	RUNX1	AML|CML								15	51					0	0	0.000422831	0	0
KIF1B	23095	broad.mit.edu	37	1	10352150	10352150	+	Silent	SNP	A	G	G			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr1:10352150A>G	uc001aqx.3	+	17	1762	c.1560A>G	c.(1558-1560)GGA>GGG	p.G520G	KIF1B_uc001aqv.3_Silent_p.G474G|KIF1B_uc001aqw.3_Silent_p.G474G|KIF1B_uc001aqy.2_Silent_p.G494G|KIF1B_uc001aqz.2_Silent_p.G520G|KIF1B_uc001ara.2_Silent_p.G480G|KIF1B_uc001arb.2_Silent_p.G506G	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	520					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		GGGAAGATGGAGGAACCCTAG	0.408000													3	160					0	0	0.00024832	0	0
PQLC2	54896	broad.mit.edu	37	1	19644334	19644335	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr1:19644334_19644335CC>AA	uc001bby.2	+	3	515_516	c.163_164CC>AA	c.(163-165)CCC>AAC	p.P55N	PQLC2_uc001bbz.2_Intron|PQLC2_uc001bca.2_Missense_Mutation_p.P55N|PQLC2_uc001bcb.2_Intron|PQLC2_uc001bcc.2_5'UTR	NM_017765	NP_060235	Q6ZP29	PQLC2_HUMAN	PQ loop repeat containing 2 isoform 1	55	PQ-loop 1.|Helical; (Potential).					integral to membrane					0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;1.89e-05)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		ATCTACCTTCCCGTGAGTAGTG	0.624000													8	356					0	0	6.4e-05	0	0
ARID1A	8289	broad.mit.edu	37	1	27094329	27094329	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr1:27094329G>A	uc001bmv.1	+	11	3410	c.3037G>A	c.(3037-3039)GAG>AAG	p.E1013K	ARID1A_uc001bmt.1_Missense_Mutation_p.E1013K|ARID1A_uc001bmu.1_Missense_Mutation_p.E1013K|ARID1A_uc001bmw.1_Missense_Mutation_p.E630K	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1013					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CAAGTTGTATGAGCTGGGTGG	0.488000			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								28	94					0	0	0.00106085	0	0
MACF1	23499	broad.mit.edu	37	1	39798098	39798098	+	Silent	SNP	A	T	T			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr1:39798098A>T	uc010oiu.1	+	1	1289	c.1158A>T	c.(1156-1158)CTA>CTT	p.L386L	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	1951					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAGCAGTTCTACCGTGCAGCA	0.443000													14	62					0	0	0.000308642	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144856892	144856892	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr1:144856892T>C	uc001elw.3	-	40	6884	c.6593A>G	c.(6592-6594)AAG>AGG	p.K2198R	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.K2092R|PDE4DIP_uc001elv.3_Missense_Mutation_p.K1205R	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	2198					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GACCAGCAGCTTGCCCTCCGC	0.517000			T	PDGFRB	MPD								5	76					0	0	8.12818e-05	0	0
ADAR	103	broad.mit.edu	37	1	154574720	154574720	+	Missense_Mutation	SNP	A	T	T			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr1:154574720A>T	uc001ffh.2	-	2	598	c.398T>A	c.(397-399)CTG>CAG	p.L133Q	ADAR_uc001ffj.2_Missense_Mutation_p.L133Q|ADAR_uc001ffi.2_Missense_Mutation_p.L133Q|ADAR_uc001ffk.2_5'UTR|ADAR_uc001ffl.1_5'UTR|ADAR_uc001ffm.1_RNA|ADAR_uc001ffn.1_Nonstop_Mutation_p.*88R	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	133	DRADA 1.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		GTAGATACTCAGTTCCTGGAA	0.517000													22	66					0	0	0.000229342	0	0
FCRL4	83417	broad.mit.edu	37	1	157559028	157559028	+	Silent	SNP	T	C	C			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr1:157559028T>C	uc001fqw.2	-	3	409	c.273A>G	c.(271-273)CCA>CCG	p.P91P	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	91	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				GGTTACTTCGTGGGGAGCCCC	0.498000													26	105					0	0	0.000184323	0	0
MPZL1	9019	broad.mit.edu	37	1	167745333	167745333	+	Missense_Mutation	SNP	A	C	C			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr1:167745333A>C	uc001geo.2	+	5	840	c.638A>C	c.(637-639)AAG>ACG	p.K213T	MPZL1_uc001gep.2_Intron|MPZL1_uc001geq.2_Intron|MPZL1_uc009wvh.2_RNA	NM_003953	NP_003944	O95297	MPZL1_HUMAN	myelin protein zero-like 1 isoform a	213	Cytoplasmic (Potential).				cell-cell signaling|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	protein binding|structural molecule activity			ovary(2)	2	all_hematologic(923;0.215)					TCACCAGTTAAGCAGGCTCCT	0.413000													10	62					0	0	0.000673444	0	0
CACYBP	27101	broad.mit.edu	37	1	174979129	174979129	+	Missense_Mutation	SNP	G	T	T			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr1:174979129G>T	uc001gkj.1	+	6	1026	c.601G>T	c.(601-603)GAT>TAT	p.D201Y	CACYBP_uc001gki.1_Missense_Mutation_p.D158Y	NM_014412	NP_055227	Q9HB71	CYBP_HUMAN	calcyclin binding protein isoform 1	201	SGS.|Interaction with S100A6 (By similarity).|Interaction with SKP1.					beta-catenin destruction complex	protein homodimerization activity				0						AATTTATGAAGATGGAGACGA	0.383000													15	46					0.000308642	0.00896825	0.000308642	1	0
KIN	22944	broad.mit.edu	37	10	7825098	7825098	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr10:7825098C>G	uc001ijt.2	-	2	203	c.155G>C	c.(154-156)AGA>ACA	p.R52T	KIN_uc010qaz.1_RNA|KIN_uc009xip.2_Missense_Mutation_p.R52T|KIN_uc010qba.1_Intron	NM_012311	NP_036443	O60870	KIN17_HUMAN	HsKin17 protein	52					DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CAATAGTTGTCTCTGATGAGA	0.328000													7	46					0	0	0.000157383	0	0
PHYH	5264	broad.mit.edu	37	10	13325784	13325785	+	Missense_Mutation	DNP	CG	AT	AT	rs62619919	byFrequency	TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr10:13325784_13325785CG>AT	uc001imf.2	-	7	821_822	c.733_734CG>AT	c.(733-735)CGG>ATG	p.R245M	PHYH_uc001ime.2_Missense_Mutation_p.R145M|PHYH_uc001img.2_Missense_Mutation_p.R228M	NM_006214	NP_006205	O14832	PAHX_HUMAN	phytanoyl-CoA 2-hydroxylase isoform a precursor	245			R -> Q (in RD; partial loss of activity).		fatty acid alpha-oxidation|nervous system development	peroxisomal matrix	electron carrier activity|L-ascorbic acid binding|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|phytanoyl-CoA dioxygenase activity|protein binding				0		Ovarian(717;0.0448)			Antihemophilic Factor(DB00025)|Vitamin C(DB00126)	CAGGTGCACCCGGGCCTTGTTT	0.500000													11	445					0	0	6.4e-05	0	0
BEST1	7439	broad.mit.edu	37	11	61730354	61730354	+	Silent	SNP	C	T	T			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr11:61730354C>T	uc001nss.2	+	10	2308	c.1728C>T	c.(1726-1728)GCC>GCT	p.A576A	BEST1_uc010rlq.1_3'UTR|BEST1_uc010rlr.1_3'UTR|BEST1_uc010rls.1_Silent_p.A204A|BEST1_uc001nsr.2_Silent_p.A516A|BEST1_uc009ynt.2_RNA|BEST1_uc010rlt.1_Silent_p.A516A|BEST1_uc001nst.2_Silent_p.A489A|BEST1_uc010rlu.1_3'UTR|BEST1_uc010rlv.1_Silent_p.A470A	NM_004183	NP_004174	O76090	BEST1_HUMAN	bestrophin 1 isoform 1	576	Cytoplasmic (Potential).				response to stimulus|transepithelial chloride transport|visual perception	basolateral plasma membrane|chloride channel complex|cytosol|membrane fraction	chloride channel activity			central_nervous_system(1)	1						CTTATTGGGCCTTGGAAAACA	0.507000													12	60					0	0	0.000978159	0	0
C12orf57	113246	broad.mit.edu	37	12	7055012	7055012	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr12:7055012A>G	uc001qrz.2	+	3	390	c.308A>G	c.(307-309)AAG>AGG	p.K103R	PTPN6_uc001qsa.1_5'Flank|PTPN6_uc010sfr.1_5'Flank	NM_138425	NP_612434	Q99622	C10_HUMAN	C10 protein	103											0						GGCAAGCTGAAGGCGCTGTTT	0.627000													4	28					0	0	0.00024832	0	0
ABCC9	10060	broad.mit.edu	37	12	21962862	21962862	+	Silent	SNP	G	A	A			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr12:21962862G>A	uc001rfi.1	-	35	4259	c.4239C>T	c.(4237-4239)TGC>TGT	p.C1413C	ABCC9_uc001rfh.2_Silent_p.C1413C|ABCC9_uc001rfj.1_Silent_p.C1377C|ABCC9_uc001rfg.2_5'Flank	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1413	Cytoplasmic (Potential).|ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TGTCATCTGTGCATTTGCACT	0.299000													20	75					0	0	0.000229342	0	0
KIAA0528	9847	broad.mit.edu	37	12	22666235	22666235	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr12:22666235T>C	uc001rfq.2	-	9	1259	c.1031A>G	c.(1030-1032)GAA>GGA	p.E344G	KIAA0528_uc010sir.1_Missense_Mutation_p.E137G|KIAA0528_uc010sis.1_Missense_Mutation_p.E344G|KIAA0528_uc010sit.1_Missense_Mutation_p.E335G|KIAA0528_uc010siu.1_Missense_Mutation_p.E344G|KIAA0528_uc001rfr.2_Missense_Mutation_p.E335G|KIAA0528_uc009ziy.1_Missense_Mutation_p.E335G	NM_014802	NP_055617	Q86YS7	K0528_HUMAN	hypothetical protein LOC9847	344							protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						TACCCTCTGTTCCAACGCTGA	0.378000													22	135					0	0	0.00106085	0	0
KRT85	3891	broad.mit.edu	37	12	52761009	52761009	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr12:52761009A>G	uc001sag.2	-	1	301	c.181T>C	c.(181-183)TCC>CCC	p.S61P		NM_002283	NP_002274	P78386	KRT85_HUMAN	keratin 85	61	Head.				epidermis development	keratin filament	protein binding|structural molecule activity			ovary(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		GGCCCGCAGGAGCCCAGGTTG	0.716000													10	35					0	0	0.000442599	0	0
SYCP3	50511	broad.mit.edu	37	12	102127436	102127436	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr12:102127436C>G	uc001tiq.2	-	6	502	c.370G>C	c.(370-372)GAA>CAA	p.E124Q	SYCP3_uc001tir.2_Missense_Mutation_p.E124Q|SYCP3_uc001tis.2_Missense_Mutation_p.E124Q	NM_153694	NP_710161	Q8IZU3	SYCP3_HUMAN	synaptonemal complex protein 3	124	Gln-rich.				cell division|male meiosis I|spermatogenesis, exchange of chromosomal proteins	nucleus	DNA binding				0						TGAGAATATTCTTGGTTAAGC	0.308000													9	63					0	0	0.000442599	0	0
NOS1	4842	broad.mit.edu	37	12	117655856	117655856	+	Silent	SNP	G	T	T			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr12:117655856G>T	uc001twm.1	-	28	4970	c.4284C>A	c.(4282-4284)ACC>ACA	p.T1428T		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	1428					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CTTACTCATCGGTGTCTTTTT	0.478000													8	287					0.000157383	0.00463939	0.000157383	1	0
USPL1	10208	broad.mit.edu	37	13	31233386	31233386	+	Missense_Mutation	SNP	A	C	C			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr13:31233386A>C	uc001utc.2	+	9	3604	c.3172A>C	c.(3172-3174)AAG>CAG	p.K1058Q	USPL1_uc001utd.2_Missense_Mutation_p.K729Q|USPL1_uc001ute.1_Missense_Mutation_p.K729Q	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	1058					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		GAGTCCGATGAAGACTGATAT	0.373000													18	79					0	0	0.000566183	0	0
ITM2B	9445	broad.mit.edu	37	13	48833064	48833064	+	Silent	SNP	A	G	G			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr13:48833064A>G	uc001vbz.3	+	5	919	c.696A>G	c.(694-696)CAA>CAG	p.Q232Q		NM_021999	NP_068839	Q9Y287	ITM2B_HUMAN	integral membrane protein 2B	232	Lumenal (Potential).				nervous system development	Golgi membrane|integral to membrane|nucleus|plasma membrane	beta-amyloid binding				0		all_cancers(8;2.2e-31)|all_epithelial(8;6.77e-15)|all_lung(13;9.67e-07)|all_hematologic(8;9.72e-06)|Lung NSC(96;8.3e-05)|Breast(56;0.000141)|Acute lymphoblastic leukemia(8;0.00045)|Prostate(109;0.000669)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;1.97e-06)		ACAAACTGCAACGCAGAGAAA	0.338000													12	58					0	0	0.00010058	0	0
Unknown	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	G	G			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr14:19857036A>G	uc001vvq.1	-	5		c.494T>C								Homo sapiens cDNA FLJ12852 fis, clone NT2RP2003445.																		CTGGATAATAAAGTTCATCTC	0.373000													3	98					0	0	6.4e-05	0	0
EDC4	23644	broad.mit.edu	37	16	67910484	67910484	+	Silent	SNP	G	A	A			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr16:67910484G>A	uc002eur.2	+	3	499	c.333G>A	c.(331-333)AAG>AAA	p.K111K	EDC4_uc010cer.2_5'UTR|EDC4_uc010vkg.1_Silent_p.K43K|EDC4_uc010ces.1_5'UTR|EDC4_uc002eus.2_5'Flank	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	111					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		TTTCAAGCAAGGCCCGGGGAA	0.537000													13	54					0	0	0.000219431	0	0
ALKBH5	54890	broad.mit.edu	37	17	18111630	18111630	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr17:18111630C>T	uc010cpw.2	+	4	1796	c.1105C>T	c.(1105-1107)CGC>TGC	p.R369C	ALKBH5_uc010cpx.2_RNA	NM_017758	NP_060228	Q6P6C2	ALKB5_HUMAN	alkB, alkylation repair homolog 5	369						integral to membrane	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0	all_neural(463;0.228)					GAACTACTGGCGCAAGTCATA	0.637000													13	130					0	0	0.000219431	0	0
ALDOC	230	broad.mit.edu	37	17	26901176	26901177	+	Missense_Mutation	DNP	CG	AT	AT	rs138221835		TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr17:26901176_26901177CG>AT	uc002hbp.2	-	7	852_853	c.707_708CG>AT	c.(706-708)CCG>CAT	p.P236H	PIGS_uc002hbn.2_5'Flank|PIGS_uc002hbo.2_5'Flank|PIGS_uc010wap.1_5'Flank|ALDOC_uc010cro.2_Missense_Mutation_p.P208H	NM_005165	NP_005156	P09972	ALDOC_HUMAN	fructose-bisphosphate aldolase C	236					fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis	cytosol	cytoskeletal protein binding|fructose-bisphosphate aldolase activity			ovary(1)	1	Lung NSC(42;0.00431)					AGGCATGGCCCGGGGTCACCAT	0.599000													6	312					0	0	6.4e-05	0	0
ADAP2	55803	broad.mit.edu	37	17	29261209	29261209	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr17:29261209G>A	uc002hfx.2	+	5	683	c.404G>A	c.(403-405)CGA>CAA	p.R135Q	ADAP2_uc010csk.2_Missense_Mutation_p.R141Q|ADAP2_uc002hfy.2_Missense_Mutation_p.R135Q|ADAP2_uc010csl.2_RNA	NM_018404	NP_060874	Q9NPF8	ADAP2_HUMAN	centaurin-alpha 2 protein	135	PH 1.				heart development|regulation of ARF GTPase activity	mitochondrial envelope|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding, bridging|zinc ion binding	p.?(1)		ovary(1)	1						TAAGGTAACCGAGAAGGATTC	0.483000													13	52					0	0	0.000308642	0	0
Unknown	0	broad.mit.edu	37	17	37188161	37188161	+	RNA	SNP	G	T	T			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr17:37188161G>T	uc002hrd.1	+	1		c.2003G>T								Homo sapiens cDNA FLJ43826 fis, clone TESTI4002703.																		TCCTCCTCCAGAGCACCTTGA	0.512000													62	140					1.12612e-26	3.52388e-25	0.000781405	1	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274291	39274291	+	Missense_Mutation	SNP	T	C	C	rs149439944	by1000genomes	TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr17:39274291T>C	uc002hvz.2	-	1	316	c.277A>G	c.(277-279)ATG>GTG	p.M93V		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	93	14.|27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			TGGCAGCACATAGACTGGCAG	0.388000													5	63					0	0	0.000274275	0	0
BRCA1	672	broad.mit.edu	37	17	41244817	41244817	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr17:41244817C>T	uc002icq.2	-	10	2963	c.2731G>A	c.(2731-2733)GGA>AGA	p.G911R	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.G840R|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.G864R|BRCA1_uc002ict.2_Missense_Mutation_p.G911R|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.G911R|BRCA1_uc002ide.1_Missense_Mutation_p.G742R|BRCA1_uc010cyy.1_Missense_Mutation_p.G911R|BRCA1_uc010whs.1_Missense_Mutation_p.G911R|BRCA1_uc010cyz.2_Missense_Mutation_p.G864R|BRCA1_uc010cza.2_Missense_Mutation_p.G885R|BRCA1_uc010wht.1_Missense_Mutation_p.G615R	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	911					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TCATTCTTTCCTTGATTTTCT	0.398000			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			21	103					0	0	0.000175454	0	0
NPEPPS	9520	broad.mit.edu	37	17	45668145	45668145	+	Silent	SNP	A	G	G			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr17:45668145A>G	uc002ilr.3	+	10	1381	c.1158A>G	c.(1156-1158)GTA>GTG	p.V386V	NPEPPS_uc010wkt.1_Silent_p.V382V|NPEPPS_uc010wku.1_Silent_p.V350V|NPEPPS_uc010wkv.1_5'UTR	NM_006310	NP_006301	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	386					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0						ATCTGTGTGTAGACCACTGCT	0.393000													25	153					0	0	0.000184323	0	0
MSI2	124540	broad.mit.edu	37	17	55754379	55754379	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr17:55754379G>A	uc002iuz.1	+	13	1150	c.977G>A	c.(976-978)GGA>GAA	p.G326E	MSI2_uc010wnm.1_Missense_Mutation_p.G322E	NM_138962	NP_620412	Q96DH6	MSI2H_HUMAN	musashi 2 isoform a	326						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)|pancreas(1)	2	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		TTTACAAATGGATACCATTGA	0.458000			T	HOXA9	CML								62	131					0	0	0.000781405	0	0
EXOC7	23265	broad.mit.edu	37	17	74081426	74081426	+	Missense_Mutation	SNP	T	A	A			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr17:74081426T>A	uc002jqs.2	-	16	1929	c.1834A>T	c.(1834-1836)ATT>TTT	p.I612F	EXOC7_uc002jqp.1_5'Flank|EXOC7_uc010dgv.1_Missense_Mutation_p.I486F|EXOC7_uc002jqq.2_Missense_Mutation_p.I561F|EXOC7_uc010wsw.1_Missense_Mutation_p.I584F|EXOC7_uc010wsx.1_Missense_Mutation_p.I553F|EXOC7_uc002jqr.2_Missense_Mutation_p.I530F|EXOC7_uc010wsv.1_Missense_Mutation_p.I533F	NM_001145297	NP_001138769	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7 isoform 4	612					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding				0			LUSC - Lung squamous cell carcinoma(166;0.187)			TGCTGCTCAATGTGCTCCCGG	0.632000													11	23					0	0	0.000151284	0	0
APCDD1	147495	broad.mit.edu	37	18	10487626	10487626	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr18:10487626C>G	uc002kom.3	+	5	1490	c.1136C>G	c.(1135-1137)GCC>GGC	p.A379G		NM_153000	NP_694545	Q8J025	APCD1_HUMAN	adenomatosis polyposis coli down-regulated 1	379	Extracellular (Potential).				hair follicle development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to plasma membrane	Wnt-protein binding				0				READ - Rectum adenocarcinoma(15;0.08)		GCGGCCACAGCCTCACTGCTC	0.597000													13	64					0	0	0.000151284	0	0
VAV1	7409	broad.mit.edu	37	19	6833546	6833546	+	Missense_Mutation	SNP	T	G	G			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr19:6833546T>G	uc002mfu.1	+	17	1715	c.1618T>G	c.(1618-1620)TTC>GTC	p.F540V	VAV1_uc010xjh.1_Missense_Mutation_p.F508V|VAV1_uc010dva.1_Missense_Mutation_p.F540V|VAV1_uc002mfv.1_Missense_Mutation_p.F485V	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	540	Phorbol-ester/DAG-type.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						CAGAGGTACCTTCTATCAGGG	0.542000													21	132					0	0	0.000375601	0	0
RBM42	79171	broad.mit.edu	37	19	36128157	36128157	+	Silent	SNP	G	A	A			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr19:36128157G>A	uc002oan.2	+	9	1309	c.1233G>A	c.(1231-1233)AAG>AAA	p.K411K	RBM42_uc010eef.2_Silent_p.K357K|RBM42_uc002oao.2_Silent_p.K389K|RBM42_uc002oap.2_Silent_p.K381K|RBM42_uc002oaq.2_Silent_p.K382K|RBM42_uc010eeg.2_Intron	NM_024321	NP_077297	Q9BTD8	RBM42_HUMAN	RNA binding motif protein 42	411	Necessary for interaction with HNRNPK (By similarity).|RRM.					cytoplasm|nucleus	nucleotide binding|RNA binding				0	all_lung(56;1.58e-07)|Lung NSC(56;2.43e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			TTAAGGCCAAGGTGATCCGTG	0.577000													13	66					0	0	0.000151284	0	0
PPP2R1A	5518	broad.mit.edu	37	19	52724382	52724382	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr19:52724382T>C	uc002pyp.2	+	12	1673	c.1514T>C	c.(1513-1515)ATC>ACC	p.I505T	PPP2R1A_uc010ydk.1_Missense_Mutation_p.I450T|PPP2R1A_uc002pyq.2_Missense_Mutation_p.I326T	NM_014225	NP_055040	P30153	2AAA_HUMAN	alpha isoform of regulatory subunit A, protein	505	PP2A subunit C binding.|HEAT 13.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			endometrium(31)|ovary(28)|lung(2)|breast(2)|skin(1)|kidney(1)|pancreas(1)	66				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		CTCTTCTGCATCAATGTGAGC	0.597000			Mis		clear cell ovarian carcinoma								33	115					0	0	0.000814825	0	0
ZNF132	7691	broad.mit.edu	37	19	58945194	58945194	+	Silent	SNP	T	A	A			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr19:58945194T>A	uc002qst.3	-	3	2018	c.1617A>T	c.(1615-1617)GGA>GGT	p.G539G		NM_003433	NP_003424	P52740	ZN132_HUMAN	zinc finger protein 132	539						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0171)|Lung(386;0.182)		AAGGCTTTTCTCCAGTGTGAA	0.478000													19	68					0	0	0.000958276	0	0
ABCA12	26154	broad.mit.edu	37	2	215865500	215865500	+	Missense_Mutation	SNP	T	G	G			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr2:215865500T>G	uc002vew.2	-	22	3328	c.3108A>C	c.(3106-3108)CAA>CAC	p.Q1036H	ABCA12_uc002vev.2_Missense_Mutation_p.Q718H|ABCA12_uc010zjn.1_5'UTR	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1036					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TCCTTCCAGTTTGCAATTCAA	0.428000													31	133					0	0	0.000409698	0	0
C2orf62	375307	broad.mit.edu	37	2	219222364	219222364	+	Nonsense_Mutation	SNP	C	T	T			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr2:219222364C>T	uc002vhr.2	+	3	255	c.226C>T	c.(226-228)CAG>TAG	p.Q76*	C2orf62_uc002vhs.2_RNA	NM_198559	NP_940961	Q7Z7H3	CB062_HUMAN	hypothetical protein LOC375307	76											0		Renal(207;0.0915)		Epithelial(149;8.08e-07)|all cancers(144;0.000146)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGGGAAATACCAGGAAAAACT	0.552000													14	67					0	0	0.000219431	0	0
SEC23B	10483	broad.mit.edu	37	20	18496315	18496315	+	Missense_Mutation	SNP	A	T	T			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr20:18496315A>T	uc002wqz.1	+	4	744	c.301A>T	c.(301-303)ATA>TTA	p.I101L	SEC23B_uc002wra.1_Missense_Mutation_p.I101L|SEC23B_uc002wrb.1_Missense_Mutation_p.I101L|SEC23B_uc010zsb.1_Missense_Mutation_p.I101L|SEC23B_uc002wrc.1_Missense_Mutation_p.I101L	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B	101					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						TTATGGAGGCATATCTGAGGT	0.348000													11	63					0	0	0.000151284	0	0
SLC25A38	54977	broad.mit.edu	37	3	39431018	39431018	+	Silent	SNP	C	T	T			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr3:39431018C>T	uc003cjo.2	+	2	503	c.102C>T	c.(100-102)GGC>GGT	p.G34G		NM_017875	NP_060345	Q96DW6	S2538_HUMAN	solute carrier family 25, member 38	34	Solcar 1.|Helical; Name=1; (Potential).				erythrocyte differentiation|heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane					0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		TCCTGTGTGGCTCCATCAGTG	0.522000													21	71					0	0	0.000295444	0	0
TNFSF10	8743	broad.mit.edu	37	3	172232704	172232704	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr3:172232704T>C	uc003fid.2	-	2	312	c.217A>G	c.(217-219)ATG>GTG	p.M73V	TNFSF10_uc003fie.2_Missense_Mutation_p.M73V	NM_003810	NP_003801	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily,	73	Extracellular (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			skin(4)|lung(1)	5	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			GGGCTGTTCATACTCTCTTCG	0.502000													39	121					0	0	0.000953801	0	0
ACOX3	8310	broad.mit.edu	37	4	8372681	8372681	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr4:8372681G>A	uc010idk.2	-	17	2082	c.1937C>T	c.(1936-1938)CCT>CTT	p.P646L	ACOX3_uc003glc.3_Missense_Mutation_p.P646L|ACOX3_uc003gld.3_Silent_p.S623S	NM_003501	NP_003492	O15254	ACOX3_HUMAN	acyl-Coenzyme A oxidase 3 isoform a	646					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			central_nervous_system(1)	1						AAAGTCAGGAGGAGCGATCAC	0.562000													10	36					0	0	0.000442599	0	0
BOD1L	259282	broad.mit.edu	37	4	13616069	13616069	+	Missense_Mutation	SNP	G	T	T			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr4:13616069G>T	uc003gmz.1	-	4	1042	c.925C>A	c.(925-927)CAG>AAG	p.Q309K	BOD1L_uc010idr.1_5'UTR|BOD1L_uc010ids.1_RNA	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	309							DNA binding			ovary(5)|breast(1)	6						CTGCTTTCCTGTTGAACATCC	0.294000													7	27					2.0095e-06	6.01076e-05	8.12818e-05	1	0
CENPC1	1060	broad.mit.edu	37	4	68385012	68385012	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr4:68385012C>G	uc003hdd.1	-	6	723	c.540G>C	c.(538-540)AAG>AAC	p.K180N	CENPC1_uc010ihj.1_RNA|CENPC1_uc010ihk.1_RNA|CENPC1_uc010ihm.1_Missense_Mutation_p.K180N	NM_001812	NP_001803	Q03188	CENPC_HUMAN	centromere protein C 1	180					mitotic prometaphase	condensed chromosome kinetochore|condensed nuclear chromosome, centromeric region|cytosol	DNA binding			urinary_tract(1)|lung(1)	2						AAGTCTCTCTCTTTTGGGCAC	0.323000													30	82					0	0	0.000227799	0	0
RNF150	57484	broad.mit.edu	37	4	141832440	141832440	+	Missense_Mutation	SNP	G	C	C			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr4:141832440G>C	uc003iio.1	-	6	1710	c.1056C>G	c.(1054-1056)AAC>AAG	p.N352K	RNF150_uc010iok.1_Missense_Mutation_p.N310K|RNF150_uc003iip.1_Missense_Mutation_p.N352K	NM_020724	NP_065775	Q9ULK6	RN150_HUMAN	ring finger protein 150 precursor	352	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)	1	all_hematologic(180;0.162)					CTGTGATCTGGTTGGTGGGTG	0.557000													12	77					0	0	0.000151284	0	0
DNAH5	1767	broad.mit.edu	37	5	13928214	13928214	+	Missense_Mutation	SNP	T	A	A			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr5:13928214T>A	uc003jfd.2	-	3	308	c.266A>T	c.(265-267)GAA>GTA	p.E89V	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	89	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TGTTTCTGCTTCCTCCACATC	0.378000									Kartagener_syndrome				17	75					0	0	0.000566183	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140772927	140772927	+	Nonsense_Mutation	SNP	C	T	T			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr5:140772927C>T	uc003lkd.1	+	1	1445	c.547C>T	c.(547-549)CAG>TAG	p.Q183*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Nonsense_Mutation_p.Q183*	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	183	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGGACGTGCAGACTGGAGA	0.612000													7	58					0	0	0.000157383	0	0
LRRC16A	55604	broad.mit.edu	37	6	25600730	25600730	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr6:25600730C>A	uc011djw.1	+	33	3684	c.3308C>A	c.(3307-3309)CCT>CAT	p.P1103H	LRRC16A_uc010jpx.2_Missense_Mutation_p.P1103H|LRRC16A_uc010jpy.2_Missense_Mutation_p.P1103H	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	1103					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						AGAAGTCCACCTGTGGACTGT	0.488000													22	51					8.10497e-08	2.49781e-06	0.000175454	1	0
KLC4	89953	broad.mit.edu	37	6	43042368	43042368	+	Silent	SNP	G	T	T			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr6:43042368G>T	uc003otv.1	+	16	1895	c.1818G>T	c.(1816-1818)CGG>CGT	p.R606R	PTK7_uc003oub.1_5'Flank|PTK7_uc003ouc.1_5'Flank|PTK7_uc003oud.1_5'Flank|PTK7_uc003oue.1_5'Flank|PTK7_uc003ouf.1_5'Flank|PTK7_uc003oug.1_5'Flank|PTK7_uc011dve.1_5'Flank|KLC4_uc003otr.1_RNA|KLC4_uc011dvd.1_Silent_p.R529R|KLC4_uc003otw.1_Silent_p.R624R|KLC4_uc003otx.1_Silent_p.R606R|KLC4_uc003oty.1_Silent_p.R606R|KLC4_uc003otz.1_Silent_p.R606R|PTK7_uc003oua.2_5'Flank	NM_201521	NP_958929	Q9NSK0	KLC4_HUMAN	kinesin-like 8 isoform a	606						cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			skin(3)|ovary(1)	4			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)			AGGTCTCCCGGGGCCTCAGTG	0.607000													9	59					7.48243e-07	2.27153e-05	0.000442599	1	0
LMBRD1	55788	broad.mit.edu	37	6	70462182	70462182	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr6:70462182T>C	uc003pfa.2	-	4	489	c.374A>G	c.(373-375)GAA>GGA	p.E125G	LMBRD1_uc003pez.2_Missense_Mutation_p.E52G|LMBRD1_uc010kal.2_Missense_Mutation_p.E52G|LMBRD1_uc003pfb.2_Intron	NM_018368	NP_060838	Q9NUN5	LMBD1_HUMAN	liver regeneration p-53 related protein	125	Cytoplasmic (Potential).				interspecies interaction between organisms|transport	integral to membrane|lysosomal membrane	cobalamin binding			ovary(1)	1						ATCATCCTTTTCTTCATAATA	0.294000													13	47					0	0	0.000308642	0	0
SYNE1	23345	broad.mit.edu	37	6	152673335	152673335	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr6:152673335T>C	uc010kiw.2	-	70	12009	c.11407A>G	c.(11407-11409)ACT>GCT	p.T3803A	SYNE1_uc003qot.3_Missense_Mutation_p.T3788A|SYNE1_uc003qou.3_Missense_Mutation_p.T3803A|SYNE1_uc010kja.1_Missense_Mutation_p.T508A	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3803	Cytoplasmic (Potential).|Potential.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTCCGGACAGTGCTGGTCAGT	0.448000										HNSCC(10;0.0054)			36	167					0	0	0.000228196	0	0
C7orf42	55069	broad.mit.edu	37	7	66410208	66410208	+	Silent	SNP	T	C	C			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr7:66410208T>C	uc003tvk.2	+	3	669	c.405T>C	c.(403-405)CAT>CAC	p.H135H	C7orf42_uc010lah.2_RNA|C7orf42_uc003tvl.2_Silent_p.H135H	NM_017994	NP_060464	Q9NWD8	CG042_HUMAN	hypothetical protein LOC55069	135						integral to membrane				ovary(1)	1						ACGTCACCCATCTGTACTCAA	0.527000													32	159					0	0	0.000814825	0	0
ING3	54556	broad.mit.edu	37	7	120595620	120595620	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr7:120595620A>G	uc003vjn.2	+	4	343	c.209A>G	c.(208-210)TAT>TGT	p.Y70C	ING3_uc011knr.1_Missense_Mutation_p.Y70C|ING3_uc003vjl.2_Missense_Mutation_p.Y70C|ING3_uc003vjm.1_Missense_Mutation_p.Y70C|ING3_uc003vjo.2_5'UTR|ING3_uc003vjp.2_Missense_Mutation_p.Y70C|ING3_uc011kns.1_Missense_Mutation_p.Y55C	NM_019071	NP_061944	Q9NXR8	ING3_HUMAN	inhibitor of growth family, member 3 isoform 1	70					histone H2A acetylation|histone H4 acetylation|positive regulation of apoptosis|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Piccolo NuA4 histone acetyltransferase complex	zinc ion binding			ovary(1)	1	all_neural(327;0.117)					CAGGACTACTATAAAGCTTTG	0.299000													3	27					0	0	0.00024832	0	0
MCPH1	79648	broad.mit.edu	37	8	6302006	6302006	+	Missense_Mutation	SNP	A	T	T			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr8:6302006A>T	uc003wqi.2	+	8	831	c.763A>T	c.(763-765)ATT>TTT	p.I255F	MCPH1_uc003wqh.2_Missense_Mutation_p.I255F|MCPH1_uc011kwl.1_Missense_Mutation_p.I207F	NM_024596	NP_078872	Q8NEM0	MCPH1_HUMAN	microcephalin	255						microtubule organizing center				central_nervous_system(1)|skin(1)	2		Hepatocellular(245;0.0663)		Colorectal(4;0.0505)		GGAAGGATCCATTAATGACAT	0.358000													21	57					0	0	0.000229342	0	0
IKBKB	3551	broad.mit.edu	37	8	42173753	42173753	+	Missense_Mutation	SNP	T	A	A			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr8:42173753T>A	uc003xow.1	+	10	1003	c.826T>A	c.(826-828)TGG>AGG	p.W276R	IKBKB_uc003xov.2_Missense_Mutation_p.W276R|IKBKB_uc010lxh.1_Missense_Mutation_p.W171R|IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Missense_Mutation_p.W53R|IKBKB_uc003xox.1_5'UTR|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Missense_Mutation_p.W274R|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Missense_Mutation_p.W217R	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	276	Protein kinase.				anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	ACTGGAGAAGTGGCTGCAACT	0.562000													9	32					0	0	0.000274275	0	0
FBXL6	26233	broad.mit.edu	37	8	145579793	145579793	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr8:145579793T>C	uc003zcb.2	-	8	1332	c.1307A>G	c.(1306-1308)CAG>CGG	p.Q436R	C8ORFK29_uc011llb.1_5'Flank|C8ORFK29_uc010mfw.2_5'Flank|C8ORFK29_uc003zby.3_5'Flank|FBXL6_uc003zbz.2_Missense_Mutation_p.Q163R|FBXL6_uc003zca.2_Missense_Mutation_p.Q430R|FBXL6_uc010mfx.2_Missense_Mutation_p.Q197R|GPR172A_uc003zcc.1_5'Flank|GPR172A_uc003zcd.1_5'Flank|GPR172A_uc003zce.1_5'Flank|GPR172A_uc010mfy.1_5'Flank|GPR172A_uc003zcf.1_5'Flank|GPR172A_uc011llc.1_5'Flank	NM_012162	NP_036294	Q8N531	FBXL6_HUMAN	F-box and leucine-rich repeat protein 6 isoform	436	LRR 9.				proteolysis		ubiquitin-protein ligase activity			ovary(1)|lung(1)	2	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			GCACCACTTCTGGGTCAAAAA	0.592000													24	104					0	0	0.000586117	0	0
SVEP1	79987	broad.mit.edu	37	9	113198779	113198779	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr9:113198779C>T	uc010mtz.2	-	28	4982	c.4645G>A	c.(4645-4647)GGT>AGT	p.G1549S		NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1549	Pentaxin.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						ACTAACGCACCACCACCTAAG	0.453000													6	15					0	0	3.59834e-05	0	0
TRAF5	7188	broad.mit.edu	37	1	211545951	211545952	+	Frame_Shift_Ins	INS	-	C	C			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr1:211545951_211545952insC	uc001hih.2	+	11	1641_1642	c.1581_1582insC	c.(1579-1584)CATTCTfs	p.H527fs	TRAF5_uc001hii.2_Frame_Shift_Ins_p.H527fs|TRAF5_uc010psx.1_Frame_Shift_Ins_p.H538fs|TRAF5_uc010psy.1_Frame_Shift_Ins_p.H421fs|TRAF5_uc001hij.2_Frame_Shift_Ins_p.H527fs	NM_004619	NP_004610	O00463	TRAF5_HUMAN	TNF receptor-associated factor 5	527_528	MATH.				apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis	CD40 receptor complex|centrosome|internal side of plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(2)|ovary(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00946)|all cancers(67;0.0808)|Epithelial(68;0.144)		TTGTGGCTCATTCTGTTTTGGA	0.465													20	102	---	---	---	---					
PAR4	347745	broad.mit.edu	37	15	25453169	25453173	+	RNA	DEL	GCTGT	-	-			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr15:25453169_25453173delGCTGT	uc001yzk.1	+	12		c.1737_1741delGCTGT			PAR4_uc010ayo.1_Intron|SNORD115-20_uc001yzq.1_Intron|SNORD115-22_uc001yzr.1_5'Flank					Homo sapiens clone Rt-13I SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.												0						CCTGCCCTGAGCTGTGGTGAGCCCA	0.585													19	77	---	---	---	---					
SGK269	79834	broad.mit.edu	37	15	77406883	77406886	+	Frame_Shift_Del	DEL	TCCC	-	-			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr15:77406883_77406886delTCCC	uc002bcm.2	-	6	5161_5164	c.4853_4856delGGGA	c.(4852-4857)AGGGAAfs	p.R1618fs		NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	1618_1619	Protein kinase.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		TCGTGTGTATTCCCTCTCCTTCAG	0.559													9	26	---	---	---	---					
TEKT1	83659	broad.mit.edu	37	17	6718552	6718553	+	Frame_Shift_Ins	INS	-	A	A			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr17:6718552_6718553insA	uc002gdt.2	-	5	668_669	c.558_559insT	c.(556-561)GATATCfs	p.D186fs	TEKT1_uc010vth.1_Frame_Shift_Ins_p.D40fs	NM_053285	NP_444515	Q969V4	TEKT1_HUMAN	tektin 1	186_187					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|skin(1)	2		Myeloproliferative disorder(207;0.0255)				GAGAAGCAGATATCATCTATGG	0.480													37	228	---	---	---	---					
SP100	6672	broad.mit.edu	37	2	231338157	231338157	+	Splice_Site	DEL	T	-	-			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr2:231338157delT	uc002vqt.2	+	16	1687	c.1546_splice	c.e16+2	p.D516_splice	SP100_uc002vqs.2_Splice_Site_p.D516_splice|SP100_uc002vqu.1_Splice_Site_p.D516_splice	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2						DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		ACATGATGGGTAAGGCTACCC	0.468													23	112	---	---	---	---					
CPNE9	151835	broad.mit.edu	37	3	9758767	9758768	+	Frame_Shift_Ins	INS	-	T	T			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr3:9758767_9758768insT	uc003bsd.2	+	14	1081_1082	c.910_911insT	c.(910-912)ATTfs	p.I304fs		NM_153635	NP_705899	Q8IYJ1	CPNE9_HUMAN	copine-like protein	304	VWFA.									ovary(2)	2	Medulloblastoma(99;0.227)					CACAGTAGCCATTGACTTCACG	0.411													21	81	---	---	---	---					
SLC22A13	9390	broad.mit.edu	37	3	38307615	38307616	+	Frame_Shift_Ins	INS	-	C	C			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr3:38307615_38307616insC	uc003chz.3	+	1	318_319	c.264_265insC	c.(262-267)CCACCCfs	p.P88fs	SLC22A13_uc011aym.1_RNA|SLC22A13_uc011ayn.1_Frame_Shift_Ins_p.P88fs	NM_004256	NP_004247	Q9Y226	S22AD_HUMAN	solute carrier family 22 (organic anion	88_89	Extracellular (Potential).					integral to plasma membrane	organic cation transmembrane transporter activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0533)|Kidney(284;0.067)		TGTTCCGGCCACCCCCCGCCAA	0.589													7	42	---	---	---	---					
LNP1	348801	broad.mit.edu	37	3	100148586	100148588	+	In_Frame_Del	DEL	GAT	-	-			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr3:100148586_100148588delGAT	uc003dtx.3	+	2	1293_1295	c.13_15delGAT	c.(13-15)GATdel	p.D10del	LNP1_uc003dty.3_RNA|LNP1_uc011bhb.1_RNA	NM_001085451	NP_001078920	A1A4G5	LNP1_HUMAN	leukemia NUP98 fusion partner 1	10	Poly-Asp.										0						GGAGCACAAAGATGATGATGATG	0.507													8	876	---	---	---	---					
DNAH8	1769	broad.mit.edu	37	6	38843585	38843585	+	Frame_Shift_Del	DEL	G	-	-			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chr6:38843585delG	uc003ooe.1	+	51	7788	c.7188delG	c.(7186-7188)GAGfs	p.E2396fs		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CCATGTATGAGTTTTATGTTA	0.338													8	43	---	---	---	---					
PAK3	5063	broad.mit.edu	37	X	110406206	110406208	+	In_Frame_Del	DEL	GAA	-	-			TCGA-G7-6796-01A-11D-1961-08	TCGA-G7-6796-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	d747a9f3-e148-4273-883e-8b64db6779a2	82db6745-95f5-4b86-acd4-8aeb5ec873db	g.chrX:110406206_110406208delGAA	uc004epa.2	+	6	604_606	c.577_579delGAA	c.(577-579)GAAdel	p.E197del	PAK3_uc010npt.1_In_Frame_Del_p.E182del|PAK3_uc010npu.1_In_Frame_Del_p.E182del|PAK3_uc004eoy.1_5'UTR|PAK3_uc004eoz.2_In_Frame_Del_p.E182del|PAK3_uc011mst.1_RNA|PAK3_uc010npv.1_In_Frame_Del_p.E218del|PAK3_uc010npw.1_In_Frame_Del_p.E203del	NM_001128173	NP_001121645	O75914	PAK3_HUMAN	p21-activated kinase 3 isoform d	197	Linker.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			lung(6)|ovary(3)|large_intestine(1)	10						agatgaagaggaagaagaagaag	0.325										TSP Lung(19;0.15)			7	119	---	---	---	---					
