Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GBP6	163351	broad.mit.edu	37	1	89846141	89846141	+	Silent	SNP	T	G	G			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr1:89846141T>G	uc001dnf.2	+	6	1096	c.822T>G	c.(820-822)ACT>ACG	p.T274T	GBP6_uc010ost.1_Silent_p.T144T	NM_198460	NP_940862	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	274							GTP binding|GTPase activity			ovary(2)	2		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		ACATCTTCACTCATGCAAGAA	0.418000													20	14					0	0	0.000175454	0	0
CELSR2	1952	broad.mit.edu	37	1	109803706	109803707	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr1:109803706_109803707CG>AT	uc001dxa.3	+	3	4062_4063	c.4001_4002CG>AT	c.(4000-4002)CCG>CAT	p.P1334H		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1334	Extracellular (Potential).|EGF-like 3; calcium-binding.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CGTTGCACCCCGGGTGTCTGCA	0.589000													10	311					0	0	6.4e-05	0	0
CD53	963	broad.mit.edu	37	1	111437611	111437611	+	Silent	SNP	C	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr1:111437611C>A	uc001dzw.2	+	6	528	c.357C>A	c.(355-357)ACC>ACA	p.T119T	CD53_uc001dzx.2_Silent_p.T119T|CD53_uc010owa.1_Intron|CD53_uc001dzy.2_Silent_p.T119T	NM_001040033	NP_001035122	P19397	CD53_HUMAN	CD53 antigen	119	Extracellular (Potential).				signal transduction	integral to membrane|plasma membrane					0		all_cancers(81;1.06e-05)|all_epithelial(167;1.95e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0264)|Colorectal(144;0.0375)|all cancers(265;0.11)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.141)|LUSC - Lung squamous cell carcinoma(189;0.144)		AGGGTCTGACCGACAGCATCC	0.507000													36	66					1.67305e-13	3.34609e-12	0.000228196	1	0
PIAS3	10401	broad.mit.edu	37	1	145578322	145578322	+	Silent	SNP	C	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr1:145578322C>A	uc001eoc.1	+	2	376	c.285C>A	c.(283-285)CCC>CCA	p.P95P	NBPF10_uc001emp.3_Intron|PIAS3_uc010oyy.1_Silent_p.P86P|PIAS3_uc001eod.1_5'Flank	NM_006099	NP_006090	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	95	Pro-rich.				positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CTCTAGCTCCCATTCCCCCAA	0.657000													50	57					3.81248e-40	7.92651e-39	0.000147903	1	0
RPTN	126638	broad.mit.edu	37	1	152127939	152127940	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr1:152127939_152127940GG>TT	uc001ezs.1	-	3	1700_1701	c.1635_1636CC>AA	c.(1633-1638)TCCCAC>TCAAAC	p.H546N		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	546	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						TGACCATAGTGGGAACTCTGGC	0.525000													13	726					0	0	6.4e-05	0	0
FLG	2312	broad.mit.edu	37	1	152280936	152280937	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr1:152280936_152280937CG>AT	uc001ezu.1	-	3	6461_6462	c.6425_6426CG>AT	c.(6424-6426)CCG>CAT	p.P2142H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2142	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCTTGGCCCCGGGTGTCCACG	0.574000									Ichthyosis				8	449					0	0	6.4e-05	0	0
DCST1	149095	broad.mit.edu	37	1	155011916	155011916	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr1:155011916C>T	uc001fgn.1	+	5	396	c.300C>T	c.(298-300)ATC>ATT	p.I100I	DCST1_uc010per.1_Silent_p.I125I|DCST1_uc010pes.1_Silent_p.I75I	NM_152494	NP_689707	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1 isoform 1	100	Helical; (Potential).					integral to membrane	zinc ion binding			ovary(1)|skin(1)	2	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CCCCTCACATCCGCTGTGCCA	0.602000													59	64					0	0	0.000147903	0	0
PEAR1	375033	broad.mit.edu	37	1	156873722	156873722	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr1:156873722T>A	uc001fqj.1	+	2	120	c.4T>A	c.(4-6)TCA>ACA	p.S2T	PEAR1_uc009wsl.1_5'Flank|PEAR1_uc001fqk.1_5'Flank	NM_001080471	NP_001073940	Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	2						integral to membrane				ovary(2)|central_nervous_system(1)	3	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTCTGCAATGTCACCGCCTCT	0.637000													49	80					0	0	0.000147903	0	0
FCRL1	115350	broad.mit.edu	37	1	157771705	157771705	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr1:157771705C>T	uc001frg.2	-	5	999	c.886G>A	c.(886-888)GTG>ATG	p.V296M	FCRL1_uc001frf.2_RNA|FCRL1_uc001frh.2_Missense_Mutation_p.V296M|FCRL1_uc001fri.2_Missense_Mutation_p.G296R|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	296	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TGAGCTATACCTGTGAAGTTG	0.552000													39	47					0	0	0.000437636	0	0
KIF21B	23046	broad.mit.edu	37	1	200969662	200969662	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr1:200969662G>A	uc001gvs.1	-	11	1858	c.1541C>T	c.(1540-1542)CCC>CTC	p.P514L	KIF21B_uc001gvr.1_Missense_Mutation_p.P514L|KIF21B_uc009wzl.1_Missense_Mutation_p.P514L|KIF21B_uc010ppn.1_Missense_Mutation_p.P514L	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	514	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						CAGGGAGTAGGGGCTCCTAGC	0.662000													28	33					0	0	0.000184323	0	0
NAV1	89796	broad.mit.edu	37	1	201782312	201782312	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr1:201782312C>T	uc001gwu.2	+	27	5604	c.5257C>T	c.(5257-5259)CGG>TGG	p.R1753W	NAV1_uc001gwx.2_Missense_Mutation_p.R1362W	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1756					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						TGAGGACTTCCGGACCTGGTT	0.522000													23	45					0	0	9.22233e-05	0	0
LRRN2	10446	broad.mit.edu	37	1	204588913	204588913	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr1:204588913C>T	uc001hbe.1	-	3	596	c.208G>A	c.(208-210)GGC>AGC	p.G70S	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Missense_Mutation_p.G70S|LRRN2_uc009xbf.1_Missense_Mutation_p.G70S|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	70	LRR 1.|Extracellular (Potential).				cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GTCTGTGTGCCTGCGGGGAGT	0.627000													36	52					0	0	0.000191422	0	0
HHIPL2	79802	broad.mit.edu	37	1	222712032	222712033	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr1:222712032_222712033GG>TT	uc001hnh.1	-	5	1592_1593	c.1534_1535CC>AA	c.(1534-1536)CCA>AAA	p.P512K		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	512					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		ATTGAGATTTGGGGATTCACAA	0.416000													10	323					0	0	6.4e-05	0	0
DISP1	84976	broad.mit.edu	37	1	223176989	223176990	+	Nonsense_Mutation	DNP	CG	AT	AT			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr1:223176989_223176990CG>AT	uc001hnu.1	+	8	2397_2398	c.2250_2251CG>AT	c.(2248-2253)TCCGAG>TCATAG	p.E751*		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	751					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		TGGAGTTATCCGAGTTCCAGGT	0.460000													11	781					0	0	6.4e-05	0	0
PSEN2	5664	broad.mit.edu	37	1	227083261	227083261	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr1:227083261C>T	uc009xeo.1	+	13	1755	c.1328C>T	c.(1327-1329)TCC>TTC	p.S443F	CABC1_uc001hqm.1_5'Flank|PSEN2_uc009xep.1_Missense_Mutation_p.S442F|PSEN2_uc001hqk.2_RNA|uc001hql.1_5'Flank	NM_000447	NP_000438	P49810	PSN2_HUMAN	presenilin 2 isoform 1	443				NLVRPFMDTLASHQLYI -> RKHSRFIQMN (in Ref. 3).	amyloid precursor protein catabolic process|anti-apoptosis|apoptosis|beta-amyloid metabolic process|calcium ion transport|induction of apoptosis by extracellular signals|intracellular signal transduction|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear inner membrane|perinuclear region of cytoplasm|Z disc	aspartic-type endopeptidase activity|protein binding			lung(2)	2		Prostate(94;0.0771)				ACCCTGGCCTCCCATCAGCTC	0.542000													12	11					0	0	6.40141e-05	0	0
OBSCN	84033	broad.mit.edu	37	1	228523899	228523899	+	Splice_Site	SNP	A	G	G			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr1:228523899A>G	uc009xez.1	+	64	16511	c.16467_splice	c.e64-2	p.G5489_splice	OBSCN_uc001hsn.2_Splice_Site_p.G5489_splice|OBSCN_uc001hsr.1_Splice_Site_p.G117_splice	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and						apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TCACCTGTTTAGGACCACACA	0.567000													3	65					0	0	0.00024832	0	0
OR2L3	391192	broad.mit.edu	37	1	248224777	248224777	+	Missense_Mutation	SNP	G	A	A	rs148776094		TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr1:248224777G>A	uc001idx.1	+	1	794	c.794G>A	c.(793-795)CGA>CAA	p.R265Q	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	265	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			AGATCCCTGCGATCTCCAACA	0.507000													33	77					0	0	0.000159656	0	0
PITRM1	10531	broad.mit.edu	37	10	3181112	3181112	+	Silent	SNP	G	C	C			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr10:3181112G>C	uc010qah.1	-	22	2639	c.2607C>G	c.(2605-2607)GTC>GTG	p.V869V	PITRM1_uc001igr.1_Silent_p.V967V|PITRM1_uc001igs.1_Silent_p.V72V|PITRM1_uc001igt.1_Silent_p.V967V|PITRM1_uc009xhv.1_Silent_p.V533V|PITRM1_uc001igu.1_Silent_p.V893V|PITRM1_uc010qai.1_Silent_p.V938V|uc001igv.1_5'Flank			E7ES23	E7ES23_HUMAN	SubName: Full=cDNA FLJ54065, moderately similar to Mus musculus pitrilysin metallepetidase 1 (Pitrm1), mRNA;	869					proteolysis		metalloendopeptidase activity|zinc ion binding			pancreas(1)	1						CTGAAGGAGCGACAGGAGCAT	0.483000													85	132					0	0	0.000147903	0	0
UPF2	26019	broad.mit.edu	37	10	12077265	12077266	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr10:12077265_12077266GG>TT	uc001ila.2	-	1	631_632	c.157_158CC>AA	c.(157-159)CCT>AAT	p.P53N	UPF2_uc001ilb.2_Missense_Mutation_p.P53N|UPF2_uc001ilc.2_Missense_Mutation_p.P53N|UPF2_uc009xiz.1_Missense_Mutation_p.P53N	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	53	Glu/Lys-rich.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				CTTGTCTTCAGGGGCCTTGCTG	0.441000													14	873					0	0	6.4e-05	0	0
CACNB2	783	broad.mit.edu	37	10	18828608	18828608	+	Silent	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr10:18828608G>A	uc001ipr.2	+	14	1998	c.1938G>A	c.(1936-1938)CGG>CGA	p.R646R	CACNB2_uc009xjz.1_Silent_p.R396R|CACNB2_uc001ips.2_Silent_p.R622R|CACNB2_uc001ipt.2_Silent_p.R608R|CACNB2_uc001ipu.2_Silent_p.R618R|CACNB2_uc001ipv.2_Silent_p.R594R|CACNB2_uc009xka.1_Silent_p.R580R|CACNB2_uc001ipw.2_Silent_p.R553R|CACNB2_uc001ipx.2_Silent_p.R591R|CACNB2_uc001ipz.2_Silent_p.R568R|CACNB2_uc001ipy.2_Silent_p.R592R|CACNB2_uc010qco.1_Silent_p.R560R|CACNB2_uc001iqa.2_Silent_p.R598R|NSUN6_uc001iqb.2_Intron	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	646					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CAAAAAAACGGAATGAGGCTG	0.423000													25	40					0	0	0.000279167	0	0
ZNF488	118738	broad.mit.edu	37	10	48370853	48370853	+	Silent	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr10:48370853G>A	uc001jex.2	+	2	483	c.321G>A	c.(319-321)AGG>AGA	p.R107R	ZNF488_uc001jey.2_5'UTR	NM_153034	NP_694579	Q96MN9	ZN488_HUMAN	zinc finger protein 488	107					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGCTGCCGAGGATGAAGGACC	0.662000													12	2					0	0	6.40141e-05	0	0
PTEN	5728	broad.mit.edu	37	10	89692922	89692922	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr10:89692922T>C	uc001kfb.2	+	6	1437	c.406T>C	c.(406-408)TGT>CGT	p.C136R		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	136	Phosphatase tensin-type.		C -> Y (in CD; loss of phosphatase activity towards Ins(1,3,4,5)P3).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.C136Y(7)|p.R55fs*1(4)|p.C136F(3)|p.I135fs*44(3)|p.C136fs*1(2)|p.?(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.C136R(2)|p.I135_A137>T(1)|p.A121_F145del(1)|p.I135fs*6(1)|p.C136_A137insGM(1)|p.C136W(1)|p.T131fs*42(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGTAATGATATGTGCATATTT	0.388000		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			40	13					0	0	0.000270559	0	0
RPL13AP6	644511	broad.mit.edu	37	10	112696659	112696659	+	Silent	SNP	A	G	G			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr10:112696659A>G	uc010qrh.1	-	1	355	c.333T>C	c.(331-333)CCT>CCC	p.P111P	SHOC2_uc001kzl.3_Intron|SHOC2_uc009xxx.2_Intron|SHOC2_uc010qrg.1_Intron	NR_026715				SubName: Full=cDNA FLJ51256, highly similar to 60S ribosomal protein L13a;												0						TCTTGTCGTAAGGCGGTGGGA	0.577000													3	9					0	0	1.23904e-05	0	0
MUC5B	727897	broad.mit.edu	37	11	1273675	1273675	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr11:1273675C>T	uc009ycr.1	+	53	16058	c.15932C>T	c.(15931-15933)TCC>TTC	p.S5311F	MUC5B_uc001ltb.2_Missense_Mutation_p.S4992F	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4989					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TGTCCCACCTCCCCACCGCCA	0.652000													28	21					0	0	9.22233e-05	0	0
OR51V1	283111	broad.mit.edu	37	11	5221880	5221880	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr11:5221880C>T	uc010qyz.1	-	1	51	c.51G>A	c.(49-51)ACG>ACA	p.T17T		NM_001004760	NP_001004760	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V,	17	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGAAGAATTCGTGCTGGTGC	0.428000													27	34					0	0	9.22233e-05	0	0
UBQLN3	50613	broad.mit.edu	37	11	5529400	5529400	+	Silent	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr11:5529400G>A	uc001may.1	-	2	1475	c.1389C>T	c.(1387-1389)TCC>TCT	p.S463S	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_5'Flank|OR51B5_uc001maq.1_5'Flank	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	463										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGCCGTGGGGGAAAAAGATA	0.547000													25	27					0	0	0.000586117	0	0
ZNF215	7762	broad.mit.edu	37	11	6953610	6953610	+	Missense_Mutation	SNP	A	G	G	rs11041107	byFrequency	TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr11:6953610A>G	uc001mey.2	+	3	695	c.107A>G	c.(106-108)AAC>AGC	p.N36S	ZNF215_uc010raw.1_Missense_Mutation_p.N36S|ZNF215_uc010rax.1_5'UTR|ZNF215_uc001mez.1_Missense_Mutation_p.N36S	NM_013250	NP_037382	Q9UL58	ZN215_HUMAN	zinc finger protein 215	36					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		CAGGAAACCAACCCCGTCGTG	0.493000													29	67					0	0	0.000184323	0	0
PTPN5	84867	broad.mit.edu	37	11	18750513	18750513	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr11:18750513C>T	uc001mpd.2	-	15	2097	c.1666G>A	c.(1666-1668)GAA>AAA	p.E556K	IGSF22_uc009yht.2_5'Flank|IGSF22_uc001mpa.2_5'Flank|PTPN5_uc001mpb.2_Missense_Mutation_p.E524K|PTPN5_uc001mpc.2_Missense_Mutation_p.E556K|PTPN5_uc001mpe.2_Missense_Mutation_p.E524K|PTPN5_uc010rdj.1_Missense_Mutation_p.E500K|PTPN5_uc001mpf.2_Missense_Mutation_p.E532K|PTPN5_uc010rdk.1_Missense_Mutation_p.E501K	NM_006906	NP_008837	P54829	PTN5_HUMAN	protein-tyrosine-phosphatase non-receptor 5	556						integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(2)	2						AGCTGCTTTTCGTAGAGGCTC	0.622000													34	31					0	0	0.000191422	0	0
TTC17	55761	broad.mit.edu	37	11	43471746	43471746	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr11:43471746C>T	uc001mxi.2	+	20	2915	c.2901C>T	c.(2899-2901)TCC>TCT	p.S967S	TTC17_uc010rfj.1_Silent_p.S967S|TTC17_uc001mxl.2_Silent_p.S23S	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	967							binding			ovary(5)	5						ATGGGGTTTCCAACCGAGCCA	0.517000													12	40					0	0	0.000151284	0	0
ZNF408	79797	broad.mit.edu	37	11	46726807	46726807	+	Silent	SNP	C	A	A	rs148867575		TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr11:46726807C>A	uc001nde.1	+	5	1787	c.1557C>A	c.(1555-1557)ACC>ACA	p.T519T	ZNF408_uc010rgw.1_Silent_p.T511T	NM_024741	NP_079017	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	519					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding				0						GGCTCCACACCGGGGAGCGTC	0.637000													36	33					2.28855e-06	4.50366e-05	0.000132358	1	0
MADD	8567	broad.mit.edu	37	11	47345360	47345360	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr11:47345360C>A	uc001ner.1	+	31	4707	c.4516C>A	c.(4516-4518)CAG>AAG	p.Q1506K	MADD_uc001neq.2_Missense_Mutation_p.Q1447K|MADD_uc001nev.1_Missense_Mutation_p.Q1404K|MADD_uc001nes.1_Missense_Mutation_p.Q1424K|MADD_uc001net.1_Missense_Mutation_p.Q1467K|MADD_uc009yln.1_Missense_Mutation_p.Q1400K|MADD_uc001neu.1_Missense_Mutation_p.Q1404K|MADD_uc001nex.2_Missense_Mutation_p.Q1506K|MADD_uc001nez.2_Missense_Mutation_p.Q1403K|MADD_uc001new.2_Missense_Mutation_p.Q1446K|MADD_uc009ylo.2_Missense_Mutation_p.Q420K	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	1506					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		CTCTGAGACCCAGCTCAACAA	0.463000													31	20					3.76114e-14	7.56338e-13	0.000132358	1	0
SLC22A10	387775	broad.mit.edu	37	11	63071674	63071674	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr11:63071674C>T	uc009yor.2	+	8	1588	c.1380C>T	c.(1378-1380)ATC>ATT	p.I460I	SLC22A10_uc010rmo.1_Intron|SLC22A10_uc001nwu.3_RNA|SLC22A10_uc010rmp.1_Missense_Mutation_p.S254F	NM_001039752	NP_001034841	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	460	Extracellular (Potential).					integral to membrane	transmembrane transporter activity			ovary(2)	2						TTGAACTCATCCCCACTGTTC	0.458000													45	71					0	0	0.000589545	0	0
HRASLS5	117245	broad.mit.edu	37	11	63233660	63233660	+	Silent	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr11:63233660G>A	uc001nwy.2	-	5	843	c.669C>T	c.(667-669)ATC>ATT	p.I223I	HRASLS5_uc001nwz.2_Silent_p.I213I|HRASLS5_uc010rmq.1_Silent_p.I223I|HRASLS5_uc009yos.2_RNA	NM_054108	NP_473449	Q96KN8	HRSL5_HUMAN	HRAS-like suppressor family, member 5 isoform 1	223										ovary(1)	1						TGTACTGCACGATCTTGTTGA	0.517000													48	41					0	0	0.000125731	0	0
TBC1D10C	374403	broad.mit.edu	37	11	67177173	67177173	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr11:67177173G>A	uc001ola.2	+	10	1318	c.1289G>A	c.(1288-1290)GGG>GAG	p.G430E	PPP1CA_uc001okx.1_Intron|TBC1D10C_uc001okz.2_3'UTR|TBC1D10C_uc001olb.2_RNA	NM_198517	NP_940919	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	430	Interaction with calcineurin.					intracellular	Rab GTPase activator activity				0			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			CCCATCGAGGGGCCCCCCAGG	0.682000													12	15					0	0	0.000308642	0	0
FAT3	120114	broad.mit.edu	37	11	92088078	92088079	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr11:92088078_92088079CC>AA	uc001pdj.3	+	1	2817_2818	c.2800_2801CC>AA	c.(2800-2802)CCA>AAA	p.P934K		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	934	Cadherin 8.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGACTGCTCCCCAGCTTTCATT	0.446000										TCGA Ovarian(4;0.039)			13	622					0	0	6.4e-05	0	0
TMEM225	338661	broad.mit.edu	37	11	123755980	123755980	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr11:123755980C>T	uc001pzi.2	-	1	361	c.153G>A	c.(151-153)ATG>ATA	p.M51I		NM_001013743	NP_001013765	Q6GV28	TM225_HUMAN	transmembrane protein 225	51						integral to membrane				upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	3						GGCAACACATCATCCAAGGAC	0.458000													26	57					0	0	0.000586117	0	0
DCP1B	196513	broad.mit.edu	37	12	2062350	2062350	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr12:2062350C>G	uc001qjx.1	-	7	836	c.756G>C	c.(754-756)CAG>CAC	p.Q252H	DCP1B_uc010sdy.1_Missense_Mutation_p.Q150H	NM_152640	NP_689853	Q8IZD4	DCP1B_HUMAN	decapping enzyme Dcp1b	252	Poly-Gln.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			gctgctgctgctgGTGGAGAG	0.458000													3	83					0	0	6.4e-05	0	0
PRMT8	56341	broad.mit.edu	37	12	3600829	3600829	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr12:3600829G>A	uc001qmf.2	+	1	405	c.38G>A	c.(37-39)AGG>AAG	p.R13K	PRMT8_uc009zed.2_Intron|uc001qmd.1_Intron	NM_019854	NP_062828	Q9NR22	ANM8_HUMAN	HMT1 hnRNP methyltransferase-like 4	13					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			ovary(3)|central_nervous_system(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			CTGCTCCTGAGGAGGAAAATG	0.647000													16	28					0	0	7.07596e-05	0	0
NCAPD2	9918	broad.mit.edu	37	12	6636085	6636085	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr12:6636085C>T	uc001qoo.2	+	22	2809	c.2763C>T	c.(2761-2763)TTC>TTT	p.F921F	NCAPD2_uc009zen.1_Silent_p.F793F|NCAPD2_uc010sfd.1_Silent_p.F876F	NM_014865	NP_055680	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	921					cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			ovary(2)|lung(1)|breast(1)|kidney(1)	5						TCCCCACTTTCCTGTTGATGA	0.572000													44	63					0	0	0.000589545	0	0
MANSC1	54682	broad.mit.edu	37	12	12496107	12496107	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr12:12496107C>T	uc001rai.1	-	2	400	c.142G>A	c.(142-144)GGA>AGA	p.G48R	MANSC1_uc001raj.1_Missense_Mutation_p.G14R|MANSC1_uc009zht.1_Intron	NM_018050	NP_060520	Q9H8J5	MANS1_HUMAN	MANSC domain containing 1 precursor	48	MANSC.|Extracellular (Potential).					integral to membrane					0		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		CCTCTGATTCCCTTAGAAAGA	0.383000													39	65					0	0	0.000191422	0	0
NELL2	4753	broad.mit.edu	37	12	44913862	44913862	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr12:44913862C>T	uc001rog.2	-	19	2921	c.2326G>A	c.(2326-2328)GAA>AAA	p.E776K	NELL2_uc001rof.3_Missense_Mutation_p.E775K|NELL2_uc001roh.2_Missense_Mutation_p.E776K|NELL2_uc009zkd.2_Missense_Mutation_p.E728K|NELL2_uc010skz.1_Missense_Mutation_p.E826K|NELL2_uc010sla.1_Missense_Mutation_p.E799K	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	776	VWFC 5.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		ACATTCATTTCGTCCAGGCAA	0.498000													39	39					0	0	0.000437636	0	0
HOXC6	3223	broad.mit.edu	37	12	54423524	54423524	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr12:54423524C>T	uc001sev.2	+	2	598	c.486C>T	c.(484-486)TTC>TTT	p.F162F	HOXC6_uc001ses.2_Silent_p.F80F|HOXC5_uc001set.2_Intron|HOXC4_uc001seu.2_Intron	NM_004503	NP_004494	P09630	HXC6_HUMAN	homeobox C6 isoform 1	162	Homeobox.				regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|upper_aerodigestive_tract(1)	3						AATTTCACTTCAATCGCTACC	0.607000													56	82					0	0	0.000147903	0	0
LOC284232	284232	broad.mit.edu	37	13	19409768	19409768	+	RNA	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr13:19409768G>A	uc010tcj.1	-	1		c.36342C>T				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						CTTTCCAGTGGATTTACTGAC	0.388000													47	76					0	0	0.000147903	0	0
PARP4	143	broad.mit.edu	37	13	25044068	25044068	+	Silent	SNP	G	A	A	rs146166448	by1000genomes	TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr13:25044068G>A	uc001upl.2	-	16	2116	c.2010C>T	c.(2008-2010)TTC>TTT	p.F670F	PARP4_uc010tdc.1_Silent_p.F670F	NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	670	VIT.				cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		TGAAGGCTTCGAAGCCACACA	0.458000													23	27					0	0	0.000184323	0	0
TRPC4	7223	broad.mit.edu	37	13	38237678	38237678	+	Silent	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr13:38237678G>A	uc001uws.2	-	6	1798	c.1563C>T	c.(1561-1563)TTC>TTT	p.F521F	TRPC4_uc010abv.2_Silent_p.F101F|TRPC4_uc001uwt.2_Silent_p.F521F|TRPC4_uc010tey.1_Silent_p.F521F|TRPC4_uc010abw.2_Silent_p.F348F|TRPC4_uc010abx.2_Silent_p.F521F|TRPC4_uc010aby.2_Silent_p.F521F	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	521	Helical; (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		GGCAGTATATGAATAGAAACT	0.403000													18	39					0	0	0.000132079	0	0
COL4A2	1284	broad.mit.edu	37	13	111147731	111147731	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr13:111147731G>A	uc001vqx.2	+	40	3966	c.3677G>A	c.(3676-3678)GGG>GAG	p.G1226E		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	1226	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGCCCTCCTGGGGAAAGAGGT	0.567000													29	51					0	0	0.000117367	0	0
ATP11A	23250	broad.mit.edu	37	13	113508685	113508685	+	Missense_Mutation	SNP	C	T	T	rs139917817		TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr13:113508685C>T	uc001vsi.3	+	19	2172	c.2084C>T	c.(2083-2085)GCG>GTG	p.A695V	ATP11A_uc001vsj.3_Missense_Mutation_p.A695V|ATP11A_uc001vsm.1_Missense_Mutation_p.A571V|ATP11A_uc010ago.2_RNA	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	695	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				GAGACGGCCGCGGCCACGTGC	0.622000													6	43					0	0	3.59834e-05	0	0
IPO4	79711	broad.mit.edu	37	14	24655957	24655957	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr14:24655957C>T	uc001wmv.1	-	9	928	c.797G>A	c.(796-798)CGT>CAT	p.R266H	IPO4_uc001wmt.1_5'Flank|IPO4_uc001wmu.2_5'UTR|IPO4_uc001wmx.1_Missense_Mutation_p.R130H|IPO4_uc001wmy.1_Missense_Mutation_p.R130H|IPO4_uc010tnz.1_RNA|IPO4_uc001wmw.1_RNA|IPO4_uc001wmz.1_Missense_Mutation_p.R266H	NM_024658	NP_078934	Q8TEX9	IPO4_HUMAN	importin 4	266					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1				GBM - Glioblastoma multiforme(265;0.0087)		GCAGAGAATACGTATGCGTAT	0.502000													18	34					0	0	0.000175454	0	0
DLGAP5	9787	broad.mit.edu	37	14	55655776	55655776	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr14:55655776C>T	uc001xbs.2	-	2	339	c.122G>A	c.(121-123)CGA>CAA	p.R41Q	DLGAP5_uc001xbt.2_Missense_Mutation_p.R41Q	NM_014750	NP_055565	Q15398	DLGP5_HUMAN	discs large homolog 7 isoform a	41					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			ovary(1)|skin(1)	2						GTGTCTATTTCGTTCGTATTC	0.353000													27	40					0	0	0.000227799	0	0
SPTB	6710	broad.mit.edu	37	14	65269006	65269006	+	Silent	SNP	T	C	C			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr14:65269006T>C	uc001xht.2	-	4	558	c.504A>G	c.(502-504)GAA>GAG	p.E168E	SPTB_uc001xhr.2_Silent_p.E168E|SPTB_uc001xhs.2_Silent_p.E168E|SPTB_uc001xhu.2_Silent_p.E168E	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	168	Actin-binding.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TTTCACGACCTTCCTGAGTTT	0.468000											OREG0022735	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	13					0	0	0.00010058	0	0
NRXN3	9369	broad.mit.edu	37	14	79270122	79270122	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr14:79270122G>A	uc001xun.2	+	6	1576	c.1085G>A	c.(1084-1086)CGT>CAT	p.R362H	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.R496H	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	735	Laminin G-like 4.|Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GACACCCTGCGTCTGGAGCTG	0.552000													29	42					0	0	0.000184323	0	0
GPR65	8477	broad.mit.edu	37	14	88477401	88477401	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr14:88477401G>A	uc001xvv.2	+	2	740	c.210G>A	c.(208-210)TGG>TGA	p.W70*		NM_003608	NP_003599	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	70	Helical; Name=2; (Potential).				actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity				0						TCCCTTTATGGATTGATTATA	0.393000													56	81					0	0	0.000147903	0	0
CATSPERB	79820	broad.mit.edu	37	14	92157878	92157878	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr14:92157878C>T	uc001xzs.1	-	10	993	c.853G>A	c.(853-855)GGT>AGT	p.G285S		NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	285					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				CTTTCAAAACCACAAAAGTCT	0.328000													81	117					0	0	0.000147903	0	0
SERPINA3	12	broad.mit.edu	37	14	95088748	95088748	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr14:95088748C>T	uc001ydp.2	+	4	1067	c.988C>T	c.(988-990)CAG>TAG	p.Q330*	SERPINA3_uc001ydo.3_Nonsense_Mutation_p.Q355*|SERPINA3_uc001ydr.2_RNA|SERPINA3_uc001ydq.2_Nonsense_Mutation_p.Q330*|SERPINA3_uc001yds.2_Nonsense_Mutation_p.Q330*|SERPINA3_uc010avg.2_Nonsense_Mutation_p.Q330*	NM_001085	NP_001076	P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A, member 3	330					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|skin(1)	6		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		CATACTTCTCCAGCTGGGCAT	0.488000													27	42					0	0	0.000227799	0	0
C15orf2	23742	broad.mit.edu	37	15	24923711	24923711	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr15:24923711C>T	uc001ywo.2	+	1	3171	c.2697C>T	c.(2695-2697)TCC>TCT	p.S899S		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	899					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TCTCTCATTCCACACTTGGGG	0.498000													61	23					0	0	0.000147903	0	0
IQGAP1	8826	broad.mit.edu	37	15	90984786	90984786	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr15:90984786C>T	uc002bpl.1	+	8	799	c.698C>T	c.(697-699)CCA>CTA	p.P233L		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	233					energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			CGTAGAATTCCAGCCGACACA	0.363000													35	32					0	0	0.000132358	0	0
LRRC28	123355	broad.mit.edu	37	15	99828120	99828120	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr15:99828120C>T	uc002bva.1	+	5	504	c.349C>T	c.(349-351)CGA>TGA	p.R117*	LRRC28_uc010urs.1_RNA|LRRC28_uc002bvb.1_5'UTR|LRRC28_uc010urt.1_5'UTR|LRRC28_uc002bvc.1_Nonsense_Mutation_p.R117*|LRRC28_uc010uru.1_Nonsense_Mutation_p.R117*|LRRC28_uc002bvd.1_Intron	NM_144598	NP_653199	Q86X40	LRC28_HUMAN	leucine rich repeat containing 28	117	LRR 5.										0	Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00106)			ACGTCATCTTCGATTAGCTAA	0.373000													33	60					0	0	0.00058488	0	0
XYLT1	64131	broad.mit.edu	37	16	17211549	17211549	+	Silent	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr16:17211549G>A	uc002dfa.2	-	11	2596	c.2511C>T	c.(2509-2511)TTC>TTT	p.F837F		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	837	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						GCGCAACGAGGAATTTGGTCT	0.532000													21	45					0	0	0.000132079	0	0
CRYM	1428	broad.mit.edu	37	16	21273402	21273402	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr16:21273402G>T	uc002dik.2	-	6	836	c.751C>A	c.(751-753)CAG>AAG	p.Q251K	CRYM_uc010bwq.1_RNA|CRYM_uc002dil.2_Missense_Mutation_p.Q209K|CRYM_uc002dim.2_Missense_Mutation_p.Q251K	NM_001888	NP_001879	Q14894	CRYM_HUMAN	crystallin, mu isoform 1	251					negative regulation of transcription from RNA polymerase II promoter|sensory perception of sound|thyroid hormone transport	cytoplasm|nucleus|plasma membrane	NADP binding|protein homodimerization activity|thyroid hormone binding|transcription corepressor activity				0				GBM - Glioblastoma multiforme(48;0.0573)	Levothyroxine(DB00451)	GCAGCCTCCTGGGAATCCACG	0.577000													23	28					6.21321e-17	1.26324e-15	0.000375601	1	0
CORO1A	11151	broad.mit.edu	37	16	30199304	30199304	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr16:30199304C>T	uc002dww.2	+	8	1025	c.903C>T	c.(901-903)GCC>GCT	p.A301A	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|CORO1A_uc010bzq.2_Silent_p.A301A|CORO1A_uc010bzr.2_Silent_p.A301A|CORO1A_uc002dwx.2_Silent_p.A195A|CORO1A_uc002dwy.1_3'UTR|LOC606724_uc002dwz.1_5'Flank	NM_007074	NP_009005	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	301					cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity				0						CTTCCGAGGCCCCTTTCCTGC	0.587000													39	62					0	0	0.000319135	0	0
ITGAL	3683	broad.mit.edu	37	16	30522249	30522249	+	Silent	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr16:30522249G>A	uc002dyi.3	+	23	2843	c.2667G>A	c.(2665-2667)GGG>GGA	p.G889G	ITGAL_uc002dyj.3_Silent_p.G805G|ITGAL_uc010vev.1_Silent_p.G123G	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	889	Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	GCTCCTGGGGGGACTCGGTTG	0.567000													22	31					0	0	0.000295444	0	0
MMP2	4313	broad.mit.edu	37	16	55522457	55522457	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr16:55522457C>T	uc002ehz.3	+	6	1146	c.835C>T	c.(835-837)CTG>TTG	p.L279L	MMP2_uc010vhd.1_Silent_p.L203L|MMP2_uc010ccc.2_Silent_p.L229L	NM_004530	NP_004521	P08253	MMP2_HUMAN	matrix metalloproteinase 2 isoform a	279	Collagen-binding.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			large_intestine(3)|ovary(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	11		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	ACCCTTAGCCCTGTTCACCAT	0.542000													8	12					0	0	0.000274275	0	0
HYDIN	54768	broad.mit.edu	37	16	70891730	70891730	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr16:70891730G>A	uc002ezr.2	-	72	12298	c.12170C>T	c.(12169-12171)TCA>TTA	p.S4057L	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4058										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				GGTCCATGATGACTCAGTGAT	0.463000													5	42					0	0	3.86212e-05	0	0
MARVELD3	91862	broad.mit.edu	37	16	71668443	71668443	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr16:71668443G>A	uc002fat.2	+	3	1006	c.943G>A	c.(943-945)GGG>AGG	p.G315R	MARVELD3_uc002fau.2_Intron|MARVELD3_uc010cge.2_Intron	NM_052858	NP_443090	Q96A59	MALD3_HUMAN	MARVEL domain containing 3 isoform 2	315	MARVEL.|Helical; (Potential).					integral to membrane				skin(1)	1		Ovarian(137;0.125)				GCTCATCGCGGGGGGGTACAT	0.582000													21	29					0	0	0.000295444	0	0
GGT6	124975	broad.mit.edu	37	17	4463750	4463750	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr17:4463750C>T	uc002fyd.3	-	1	127	c.67G>A	c.(67-69)GAG>AAG	p.E23K	GGT6_uc010vsb.1_5'Flank|GGT6_uc002fyc.3_Missense_Mutation_p.E23K|GGT6_uc010vsc.1_Missense_Mutation_p.E23K	NM_001122890	NP_001116362	Q6P531	GGT6_HUMAN	gamma-glutamyltransferase 6 isoform a	23	Cytoplasmic (Potential).|Poly-Glu.				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			skin(1)	1						ACTTCCTCCTCCGACTCCAAG	0.642000													31	40					0	0	0.000409698	0	0
USP6	9098	broad.mit.edu	37	17	5073801	5073801	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr17:5073801G>A	uc002gau.1	+	36	5775	c.3545G>A	c.(3544-3546)GGA>GAA	p.G1182E	USP6_uc002gav.1_Missense_Mutation_p.G1182E|USP6_uc010ckz.1_Missense_Mutation_p.G865E	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	1182					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						AGAAAAAGTGGAACCAGCTGT	0.507000			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								17	27					0	0	0.000132079	0	0
AIPL1	23746	broad.mit.edu	37	17	6329120	6329120	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr17:6329120C>A	uc002gcp.2	-	6	910	c.815G>T	c.(814-816)CGG>CTG	p.R272L	AIPL1_uc002gcq.2_Missense_Mutation_p.R212L|AIPL1_uc002gcr.2_Missense_Mutation_p.R209L|AIPL1_uc010clk.2_Missense_Mutation_p.R250L|AIPL1_uc010cll.2_Missense_Mutation_p.R248L|AIPL1_uc002gcs.2_3'UTR	NM_014336	NP_055151	Q9NZN9	AIPL1_HUMAN	aryl hydrocarbon receptor interacting	272	TPR 3.				protein farnesylation|protein folding|visual perception	cytoplasm|nucleus	farnesylated protein binding|unfolded protein binding				0				COAD - Colon adenocarcinoma(228;0.141)		TGCGTGAGCCCGGGCACGCAC	0.667000													17	26					6.94344e-10	1.38118e-08	7.07596e-05	1	0
MAP2K3	5606	broad.mit.edu	37	17	21215477	21215477	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr17:21215477C>T	uc002gys.2	+	10	1063	c.798C>T	c.(796-798)TTC>TTT	p.F266F	MAP2K3_uc002gyt.2_Silent_p.F237F|MAP2K3_uc002gyu.2_Silent_p.F237F	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	266	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		TCCTGCGGTTCCCTTACGAGT	0.672000													4	37					0	0	1.23904e-05	0	0
KCNJ12	3768	broad.mit.edu	37	17	21318660	21318660	+	Silent	SNP	C	T	T	rs148939916	byFrequency	TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr17:21318660C>T	uc002gyv.1	+	3	711	c.6C>T	c.(4-6)ACC>ACT	p.T2T		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	2	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	CCGGGATGACCGCGGCCAGCC	0.697000										Prostate(3;0.18)			9	23					0	0	0.000274275	0	0
Unknown	0	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	G	G	rs149119138	by1000genomes	TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr17:21731144T>G	uc002gyy.3	+	2	571	c.446T>G	c.(445-447)CTG>CGG	p.L149R						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;																		GTCCTGCGTCTGAGAGGTGGT	0.542000													6	71					0	0	3.59834e-05	0	0
COL1A1	1277	broad.mit.edu	37	17	48263002	48263002	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr17:48263002G>A	uc002iqm.2	-	51	4382	c.4256C>T	c.(4255-4257)ACC>ATC	p.T1419I		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	1419	Fibrillar collagen NC1.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	CCAGGCTCCGGTGTGACTCTG	0.617000			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						26	23					0	0	9.22233e-05	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14850212	14850212	+	Splice_Site	SNP	G	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr18:14850212G>T	uc010dlo.2	+	35	3219	c.3039_splice	c.e35-1	p.R1013_splice	ANKRD30B_uc010xal.1_Splice_Site_p.R155_splice	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B											ovary(1)|skin(1)	2						TTTAATGGCAGATTGACTTTA	0.269000													5	1					3.59834e-05	0.000704355	3.59834e-05	1	0
GALNT1	2589	broad.mit.edu	37	18	33257586	33257586	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr18:33257586C>T	uc010dmu.2	+	4	399	c.346C>T	c.(346-348)CCT>TCT	p.P116S	GALNT1_uc002kyz.3_Missense_Mutation_p.P56S|GALNT1_uc002kzb.2_Missense_Mutation_p.P116S	NM_020474	NP_065207	Q10472	GALT1_HUMAN	polypeptide N-acetylgalactosaminyltransferase 1	116	Lumenal (Potential).|Catalytic subdomain A.				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						AGATAATCTTCCTACAACAAG	0.388000													48	20					0	0	0.000147903	0	0
SERPINB11	89778	broad.mit.edu	37	18	61390507	61390507	+	Silent	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr18:61390507G>A	uc002ljk.3	+	9	1115	c.1053G>A	c.(1051-1053)GGG>GGA	p.G351G	SERPINB11_uc010xes.1_Silent_p.G176G|SERPINB11_uc010dqd.2_Intron|SERPINB11_uc002ljj.3_Silent_p.G237G|SERPINB11_uc010dqe.2_Silent_p.G150G|SERPINB11_uc010dqf.2_Silent_p.G149G	NM_080475	NP_536723	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B, member 11	351	RCL (By similarity).				regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)	1		Esophageal squamous(42;0.129)				CAGCCACTGGGGACAGCATCG	0.498000													35	6					0	0	0.00058488	0	0
ZNF407	55628	broad.mit.edu	37	18	72346087	72346087	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr18:72346087C>T	uc002llw.2	+	1	3169	c.3112C>T	c.(3112-3114)CGG>TGG	p.R1038W	ZNF407_uc010xfc.1_Missense_Mutation_p.R1038W|ZNF407_uc010dqu.1_Missense_Mutation_p.R1038W|ZNF407_uc002llu.2_Missense_Mutation_p.R1037W	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	1038	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GCATGTAAAACGGAAACATAC	0.463000													57	18					0	0	0.000147903	0	0
SNAPC2	6618	broad.mit.edu	37	19	7986931	7986931	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr19:7986931C>T	uc002miw.1	+	4	407	c.384C>T	c.(382-384)ATC>ATT	p.I128I	SNAPC2_uc002mix.1_RNA	NM_003083	NP_003074	Q13487	SNPC2_HUMAN	small nuclear RNA activating complex,	128					snRNA transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	sequence-specific DNA binding transcription factor activity				0						TGCTCACCATCGCGGCCACGG	0.627000													63	97					0	0	0.000147903	0	0
FBN3	84467	broad.mit.edu	37	19	8176585	8176585	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr19:8176585G>A	uc002mjf.2	-	31	4052	c.4031C>T	c.(4030-4032)TCC>TTC	p.S1344F		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1344	EGF-like 20; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GCAGCGGTAGGAGCCAGGGAC	0.647000													19	38					0	0	9.7654e-05	0	0
MUC16	94025	broad.mit.edu	37	19	9057011	9057011	+	Silent	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr19:9057011G>A	uc002mkp.2	-	3	30639	c.30435C>T	c.(30433-30435)TCC>TCT	p.S10145S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10147	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCATTGATGTGGAAATAGAGG	0.458000													19	32					0	0	7.07596e-05	0	0
MUC16	94025	broad.mit.edu	37	19	9074565	9074565	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr19:9074565G>A	uc002mkp.2	-	3	13085	c.12881C>T	c.(12880-12882)TCC>TTC	p.S4294F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4296	Thr-rich.|Extracellular (Potential).|Ser-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGTGGTCTCGGAGGAGCCAAA	0.527000													23	31					0	0	0.000375601	0	0
CYP4F3	4051	broad.mit.edu	37	19	15757879	15757879	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr19:15757879G>A	uc002nbj.2	+	4	411	c.361G>A	c.(361-363)GAC>AAC	p.D121N	CYP4F3_uc010xok.1_Missense_Mutation_p.D121N|CYP4F3_uc010xol.1_Missense_Mutation_p.D121N|CYP4F3_uc010xom.1_5'UTR|CYP4F3_uc002nbk.2_Missense_Mutation_p.D121N|CYP4F3_uc010xon.1_5'Flank	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	121					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						TGTACCAAAGGACAAGGTCTT	0.577000													36	41					0	0	0.000319135	0	0
ANKLE1	126549	broad.mit.edu	37	19	17394647	17394647	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr19:17394647C>T	uc002nga.2	+	5	1350	c.1074C>T	c.(1072-1074)GTC>GTT	p.V358V	ANKLE1_uc010xpm.1_RNA|ANKLE1_uc010eao.1_Silent_p.V380V|ANKLE1_uc010xpn.1_Silent_p.V412V|ANKLE1_uc002nfy.2_Silent_p.V347V|ANKLE1_uc002nfz.2_Silent_p.V64V	NM_152363	NP_689576	Q8NAG6	ANKL1_HUMAN	ankyrin repeat domain 41	358	LEM.					nuclear envelope					0						ACCTGCCAGTCTCCACTGTGT	0.582000													26	30					0	0	0.00047179	0	0
GLT25D1	79709	broad.mit.edu	37	19	17678331	17678331	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr19:17678331G>C	uc002nhc.1	+	4	618	c.606G>C	c.(604-606)TGG>TGC	p.W202C	GLT25D1_uc010eax.1_5'Flank	NM_024656	NP_078932	Q8NBJ5	GT251_HUMAN	glycosyltransferase 25 domain containing 1	202					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity				0						CCAACTTCTGGTGTGGAATGA	0.592000													5	19					0	0	3.59834e-05	0	0
ANKRD27	84079	broad.mit.edu	37	19	33135320	33135321	+	Nonsense_Mutation	DNP	CC	AA	AA			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr19:33135320_33135321CC>AA	uc002ntn.1	-	5	591_592	c.435_436GG>TT	c.(433-438)TTGGGA>TTTTGA	p.145_146LG>F*	ANKRD27_uc002nto.1_Nonsense_Mutation_p.145_146LG>F*	NM_032139	NP_115515	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	145_146					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)	5	Esophageal squamous(110;0.137)					GAGTGTCTTCCCAAGAACTCTC	0.500000													10	339					0	0	6.4e-05	0	0
LRFN1	57622	broad.mit.edu	37	19	39805548	39805548	+	Silent	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr19:39805548G>A	uc002okw.2	-	1	429	c.429C>T	c.(427-429)ATC>ATT	p.I143I		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	143	LRR 4.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			TGTTTCCAAGGATCAGGTGGC	0.687000													7	11					0	0	8.12818e-05	0	0
CEACAM5	1048	broad.mit.edu	37	19	42213851	42213851	+	Missense_Mutation	SNP	C	T	T	rs150911810	byFrequency	TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr19:42213851C>T	uc002ork.2	+	2	438	c.317C>T	c.(316-318)TCC>TTC	p.S106F	CEACAM5_uc010ehz.1_Missense_Mutation_p.S106F|CEACAM5_uc002orj.1_Missense_Mutation_p.S106F|CEACAM5_uc002orl.2_Missense_Mutation_p.S106F	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	106	Ig-like 1.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		CCCAATGCATCCCTGCTGATC	0.468000													74	95					0	0	0.000147903	0	0
HIF3A	64344	broad.mit.edu	37	19	46823707	46823707	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr19:46823707G>A	uc002peh.2	+	9	1062	c.1033G>A	c.(1033-1035)GAA>AAA	p.E345K	HIF3A_uc002peg.3_Missense_Mutation_p.E345K|HIF3A_uc010xxx.1_RNA|HIF3A_uc002pei.3_Missense_Mutation_p.E289K|HIF3A_uc002pej.1_Missense_Mutation_p.E276K|HIF3A_uc002pek.2_Missense_Mutation_p.E289K|HIF3A_uc010xxy.1_Missense_Mutation_p.E276K|HIF3A_uc002pel.2_Missense_Mutation_p.E343K|HIF3A_uc010xxz.1_Missense_Mutation_p.E294K	NM_152795	NP_690008	Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	345					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		CAGCCAGGTGGAAGAGACCGG	0.607000													31	53					0	0	0.000109025	0	0
GYS1	2997	broad.mit.edu	37	19	49477944	49477944	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr19:49477944G>A	uc002plp.2	-	11	1596	c.1355C>T	c.(1354-1356)TCC>TTC	p.S452F	GYS1_uc010xzy.1_Missense_Mutation_p.S85F|GYS1_uc010emm.2_Missense_Mutation_p.S388F|GYS1_uc010xzz.1_Missense_Mutation_p.S372F|GYS1_uc010yaa.1_RNA	NM_002103	NP_002094	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle) isoform 1	452					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		GGGGTCTGAGGAGTCATCCAG	0.587000													24	41					0	0	0.000117367	0	0
ZNF418	147686	broad.mit.edu	37	19	58437712	58437712	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr19:58437712G>A	uc002qqs.1	-	4	2129	c.1837C>T	c.(1837-1839)CAT>TAT	p.H613Y	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Missense_Mutation_p.H528Y	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	613	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		CCTCGAGTATGAAGTCTCTGA	0.453000													39	62					0	0	0.000191422	0	0
SLC4A10	57282	broad.mit.edu	37	2	162719558	162719558	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr2:162719558C>T	uc002ubx.3	+	6	936	c.752C>T	c.(751-753)TCC>TTC	p.S251F	SLC4A10_uc010fpa.1_Missense_Mutation_p.S263F|SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Missense_Mutation_p.S251F|SLC4A10_uc010zcs.1_Missense_Mutation_p.S262F	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	251	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						GAACCAAATTCCATGGACAAA	0.338000													31	12					0	0	0.000339439	0	0
XIRP2	129446	broad.mit.edu	37	2	168099467	168099467	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr2:168099467C>T	uc002udx.2	+	8	1583	c.1565C>T	c.(1564-1566)TCT>TTT	p.S522F	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.S347F|XIRP2_uc010fpq.2_Missense_Mutation_p.S300F|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	347					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGTGAAGTTTCTGAGATTGTT	0.328000													11	3					0	0	6.40141e-05	0	0
AGAP1	116987	broad.mit.edu	37	2	236715898	236715898	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr2:236715898G>A	uc002vvs.2	+	9	1568	c.973G>A	c.(973-975)GAC>AAC	p.D325N	AGAP1_uc002vvt.2_Missense_Mutation_p.D325N	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	centaurin, gamma 2 isoform 1	325					protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			ovary(2)|skin(1)	3						GAAAGGGAGCGACCCAGACAA	0.567000													57	13					0	0	0.000147903	0	0
FRG1B	284802	broad.mit.edu	37	20	29628263	29628263	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr20:29628263A>G	uc010ztl.1	+	3	207	c.175A>G	c.(175-177)ATT>GTT	p.I59V	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Missense_Mutation_p.I11V					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						TAGCTGCTTTATTAGATGCAA	0.363000													4	75					0	0	3.59834e-05	0	0
PTPRT	11122	broad.mit.edu	37	20	40980729	40980729	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr20:40980729A>T	uc002xkg.2	-	10	1941	c.1757T>A	c.(1756-1758)ATT>AAT	p.I586N	PTPRT_uc010ggj.2_Missense_Mutation_p.I586N	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	586	Extracellular (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GATACCTGAAATTTTGGTGGC	0.473000													34	49					0	0	0.00058488	0	0
SERINC3	10955	broad.mit.edu	37	20	43142583	43142583	+	Silent	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr20:43142583G>A	uc002xme.2	-	2	272	c.138C>T	c.(136-138)CTC>CTT	p.L46L	SERINC3_uc002xmf.1_Silent_p.L46L|SERINC3_uc010ggs.1_Silent_p.L39L|SERINC3_uc010zwp.1_5'UTR	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	46	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			TGCTCAGGAGGAGAATGAAAG	0.438000													28	64					0	0	0.000117367	0	0
SPINLW1	57119	broad.mit.edu	37	20	44171395	44171395	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr20:44171395C>T	uc002xou.2	-	3	367	c.335G>A	c.(334-336)GGA>GAA	p.G112E	SPINLW1_uc010zxc.1_Missense_Mutation_p.G112E|SPINLW1_uc002xot.2_Missense_Mutation_p.G96E|SPINLW1_uc002xov.1_3'UTR	NM_020398	NP_065131	O95925	EPPI_HUMAN	serine peptidase inhibitor-like, with Kunitz and	112	BPTI/Kunitz inhibitor.					extracellular region	serine-type endopeptidase inhibitor activity			pancreas(1)	1		Myeloproliferative disorder(115;0.0122)				GTTATTGTTTCCCTGGCAGCC	0.468000													57	84					0	0	0.000147903	0	0
ATP9A	10079	broad.mit.edu	37	20	50286611	50286611	+	Silent	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr20:50286611G>A	uc002xwg.1	-	13	1218	c.1218C>T	c.(1216-1218)CTC>CTT	p.L406L	ATP9A_uc010gih.1_Silent_p.L270L|ATP9A_uc002xwf.1_Intron	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	406	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						TTCCGAGATGGAGCCGTTTGA	0.453000													41	67					0	0	0.000509022	0	0
SALL4	57167	broad.mit.edu	37	20	50406909	50406909	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr20:50406909A>T	uc002xwh.3	-	2	2214	c.2113T>A	c.(2113-2115)TCC>ACC	p.S705T	SALL4_uc010gii.2_Intron|SALL4_uc002xwi.3_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	705					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						ACCTTGGAGGAGCTGCTGGGA	0.597000													18	31					0	0	0.000175454	0	0
ZNF831	128611	broad.mit.edu	37	20	57828183	57828183	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr20:57828183G>A	uc002yan.2	+	4	4178	c.4178G>A	c.(4177-4179)CGA>CAA	p.R1393Q		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1393						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					ATGGACAAACGAACTGTGAAG	0.468000													50	85					0	0	0.000147903	0	0
SLC5A3	6526	broad.mit.edu	37	21	35468710	35468711	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr21:35468710_35468711CG>AT	uc002yto.2	+	2	1725_1726	c.1213_1214CG>AT	c.(1213-1215)CGG>ATG	p.R405M	MRPS6_uc002ytp.2_Intron	NM_006933	NP_008864	P53794	SC5A3_HUMAN	solute carrier family 5 (inositol transporters),	405	Cytoplasmic (Potential).					integral to plasma membrane	myo-inositol:sodium symporter activity			ovary(2)	2						CGCAAGCTCCCGGGAGTTAATG	0.475000													14	692					0	0	6.4e-05	0	0
KRTAP10-11	386678	broad.mit.edu	37	21	46066862	46066862	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr21:46066862G>A	uc002zfr.3	+	1	532	c.487G>A	c.(487-489)GAG>AAG	p.E163K	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198692	NP_941965	P60412	KR10B_HUMAN	keratin associated protein 10-11	163	25 X 5 AA repeats of C-C-X(3).					keratin filament				ovary(1)	1						CACCTGCTCTGAGGATTCCTC	0.403000													65	92					0	0	0.000147903	0	0
GALNTL2	117248	broad.mit.edu	37	3	16264263	16264263	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr3:16264263G>A	uc003car.3	+	9	2246	c.1771G>A	c.(1771-1773)GAG>AAG	p.E591K	GALNTL2_uc003caq.3_Missense_Mutation_p.E324K|GALNTL2_uc003cas.3_Missense_Mutation_p.E121K	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	591	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						GGACTTCCAGGAGGTGAGTAA	0.557000													24	6					0	0	0.000375601	0	0
OR5K3	403277	broad.mit.edu	37	3	98110314	98110314	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr3:98110314G>A	uc011bgw.1	+	1	805	c.805G>A	c.(805-807)GAT>AAT	p.D269N		NM_001005516	NP_001005516	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K,	269	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGGGGATAAAGATATACCTGT	0.299000													25	5					0	0	0.000375601	0	0
ARMC8	25852	broad.mit.edu	37	3	137942489	137942490	+	Missense_Mutation	DNP	CC	AA	AA	rs111530888		TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr3:137942489_137942490CC>AA	uc003esa.1	+	6	674_675	c.307_308CC>AA	c.(307-309)CCA>AAA	p.P103K	ARMC8_uc003erw.2_Missense_Mutation_p.P103K|ARMC8_uc003erx.2_Missense_Mutation_p.P103K|ARMC8_uc003ery.2_Missense_Mutation_p.P75K|ARMC8_uc003erz.2_Missense_Mutation_p.P75K|ARMC8_uc011bmf.1_Missense_Mutation_p.P117K|ARMC8_uc011bmg.1_Missense_Mutation_p.P117K|ARMC8_uc011bmh.1_Missense_Mutation_p.P75K|ARMC8_uc003esb.1_Missense_Mutation_p.P75K	NM_015396	NP_056211	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8 isoform 2	117	ARM 2.						binding				0						ACTACTGTCCCCAGACCTGAAG	0.406000													13	581					0	0	6.4e-05	0	0
PEX5L	51555	broad.mit.edu	37	3	179593214	179593214	+	Missense_Mutation	SNP	C	T	T	rs143237596		TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr3:179593214C>T	uc003fki.1	-	6	687	c.557G>A	c.(556-558)CGA>CAA	p.R186Q	PEX5L_uc011bqd.1_Missense_Mutation_p.R143Q|PEX5L_uc011bqe.1_5'UTR|PEX5L_uc011bqf.1_Missense_Mutation_p.R78Q|PEX5L_uc003fkj.1_Missense_Mutation_p.R151Q|PEX5L_uc010hxd.1_Missense_Mutation_p.R184Q|PEX5L_uc011bqg.1_Missense_Mutation_p.R162Q|PEX5L_uc011bqh.1_Missense_Mutation_p.R127Q	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	186					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			CTTGGTATTTCGATCTCCATG	0.448000													32	47					0	0	0.000339439	0	0
ABCC5	10057	broad.mit.edu	37	3	183679345	183679345	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr3:183679345G>A	uc003fmg.2	-	16	2498	c.2333C>T	c.(2332-2334)GCT>GTT	p.A778V	ABCC5_uc011bqt.1_Missense_Mutation_p.A306V|ABCC5_uc010hxl.2_Missense_Mutation_p.A778V	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	778	ABC transporter 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			AAAAATGGTAGCATAGTCACC	0.458000													27	44					0	0	0.000586117	0	0
ATP13A5	344905	broad.mit.edu	37	3	193032880	193032880	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr3:193032880T>A	uc011bsq.1	-	18	2039	c.2039A>T	c.(2038-2040)AAA>ATA	p.K680I		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	680					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		TGACTCCACTTTTTCTCTTTG	0.328000													31	56					0	0	0.00058488	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6064049	6064049	+	Missense_Mutation	SNP	C	A	A	rs146441068		TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr4:6064049C>A	uc003giu.3	-	10	1826	c.1550G>T	c.(1549-1551)AGG>ATG	p.R517M	JAKMIP1_uc010idb.1_Missense_Mutation_p.R517M|JAKMIP1_uc010idc.1_Missense_Mutation_p.R332M|JAKMIP1_uc010idd.1_Intron|JAKMIP1_uc011bwc.1_Missense_Mutation_p.R352M|JAKMIP1_uc003giv.3_Missense_Mutation_p.R517M|JAKMIP1_uc010ide.2_Missense_Mutation_p.R517M	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	517	Mediates interaction with TYK2 and GABBR1.|Potential.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						CCGGGCCTCCCTCTCAGCGTC	0.667000													31	63					3.03874e-20	6.21253e-19	0.00058488	1	0
KDR	3791	broad.mit.edu	37	4	55956162	55956162	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr4:55956162C>T	uc003has.2	-	23	3455	c.3153G>A	c.(3151-3153)CGG>CGA	p.R1051R	KDR_uc003hat.1_Silent_p.R1051R	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	1051	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TATAAATATCCCGGGCCAAGC	0.413000			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			38	49					0	0	0.000132358	0	0
LPHN3	23284	broad.mit.edu	37	4	62813993	62813993	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr4:62813993A>G	uc010ihh.2	+	14	2773	c.2600A>G	c.(2599-2601)AAG>AGG	p.K867R	LPHN3_uc003hcq.3_Missense_Mutation_p.K867R|LPHN3_uc003hct.2_Missense_Mutation_p.K260R	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	854	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						GTGGAAGTTAAGGTAAGATAT	0.343000													18	26					0	0	9.7654e-05	0	0
GK2	2712	broad.mit.edu	37	4	80328222	80328222	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr4:80328222C>T	uc003hlu.2	-	1	1151	c.1133G>A	c.(1132-1134)GGG>GAG	p.G378E		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	378					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						ACAGAGTATCCCTCTTGCACT	0.423000													38	55					0	0	0.000228196	0	0
CENPE	1062	broad.mit.edu	37	4	104063010	104063010	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr4:104063010T>C	uc003hxb.1	-	35	5450	c.5360A>G	c.(5359-5361)CAG>CGG	p.Q1787R	CENPE_uc003hxc.1_Missense_Mutation_p.Q1762R|CENPE_uc003hxd.1_5'Flank	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	1787	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		AATAGTTTCCTGCTGCTCTTT	0.299000													31	27					0	0	0.000109025	0	0
CFI	3426	broad.mit.edu	37	4	110662164	110662164	+	Missense_Mutation	SNP	C	A	A	rs121964915		TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr4:110662164C>A	uc003hzr.3	-	13	1845	c.1637G>T	c.(1636-1638)TGG>TTG	p.W546L	CFI_uc003hzq.2_Missense_Mutation_p.W343L|CFI_uc011cft.1_Missense_Mutation_p.W554L|CFI_uc003hzs.3_Missense_Mutation_p.W539L	NM_000204	NP_000195	P05156	CFAI_HUMAN	complement factor I preproprotein	546	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		GTTTTCCCCCCAACTCACAAC	0.458000													120	172					7.61515e-48	1.59226e-46	0.000147903	1	0
PITX2	5308	broad.mit.edu	37	4	111542323	111542323	+	Silent	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr4:111542323G>A	uc003iad.2	-	4	969	c.387C>T	c.(385-387)GTC>GTT	p.V129V	PITX2_uc003iac.2_Silent_p.V136V|PITX2_uc003iae.2_Silent_p.V83V|PITX2_uc010iml.2_Intron|PITX2_uc003iaf.2_Silent_p.V129V|PITX2_uc003iag.1_Silent_p.V136V	NM_153426	NP_700475	Q99697	PITX2_HUMAN	paired-like homeodomain transcription factor 2	129	Homeobox.		V -> L (in RIEG1; more than 200% increase in transactivation activity).|Missing (in RIEG1; more than 100-fold reduction in DNA binding activity as well as no detectable transactivation activity).		determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription factor binding				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		CTCCTACCCGGACTCGGGCTT	0.612000													16	21					0	0	0.000422831	0	0
LRBA	987	broad.mit.edu	37	4	151850033	151850033	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr4:151850033A>G	uc010ipj.2	-	3	875	c.401T>C	c.(400-402)GTT>GCT	p.V134A	LRBA_uc003ilu.3_Missense_Mutation_p.V134A|LRBA_uc010ipk.1_Missense_Mutation_p.V53A	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	134						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					CACTTTTTCAACAAGGCCTAC	0.348000													32	71					0	0	0.000132358	0	0
PCDHB2	56133	broad.mit.edu	37	5	140474556	140474556	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr5:140474556T>C	uc003lil.2	+	1	320	c.182T>C	c.(181-183)CTT>CCT	p.L61P	PCDHB2_uc003lim.1_Intron	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	61	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATAGGAGAACTTGCTGTGAGG	0.502000													29	9					0	0	0.000184323	0	0
PCDHB4	56131	broad.mit.edu	37	5	140501747	140501748	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr5:140501747_140501748GG>AA	uc003lip.1	+	1	167_168	c.167_168GG>AA	c.(166-168)GGG>GAA	p.G56E		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	56	Cadherin 1.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGGGAATTGGGGAACTGGCCT	0.559000													17	9					0	0	6.4e-05	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516849	140516849	+	Silent	SNP	C	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr5:140516849C>A	uc003liq.2	+	1	2050	c.1833C>A	c.(1831-1833)CCC>CCA	p.P611P		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	611	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCACGGAGCCCGGGCTGTTCA	0.701000													62	18					1.74971e-23	3.59717e-22	0.000147903	1	0
LTB	4050	broad.mit.edu	37	6	31550182	31550182	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr6:31550182C>T	uc003nuk.2	-	1	21	c.13G>A	c.(13-15)GGG>AGG	p.G5R	LTB_uc003nul.2_Missense_Mutation_p.G5R	NM_002341	NP_002332	Q06643	TNFC_HUMAN	lymphotoxin-beta isoform a	5	Cytoplasmic (Potential).				cell-cell signaling|immune response|positive regulation of interleukin-12 biosynthetic process|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding				0					Infliximab(DB00065)|Simvastatin(DB00641)	CCCTCCAGCCCCAGTGCCCCC	0.652000													24	18					0	0	0.000117367	0	0
C6orf27	80737	broad.mit.edu	37	6	31744326	31744326	+	Silent	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr6:31744326G>A	uc011dog.1	-	2	469	c.231C>T	c.(229-231)TTC>TTT	p.F77F	C6orf27_uc003nxd.2_5'UTR|C6orf27_uc011doh.1_RNA	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	77						extracellular region				ovary(3)	3						TGCTCACCAGGAAGTCCTCAA	0.622000													107	103					0	0	0.000147903	0	0
SLC44A4	80736	broad.mit.edu	37	6	31833650	31833651	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr6:31833650_31833651CG>AT	uc010jti.2	-	14	1552_1553	c.1486_1487CG>AT	c.(1486-1488)CGT>ATT	p.R496I	NEU1_uc003nxq.3_5'Flank|NEU1_uc010jtg.2_5'Flank|NEU1_uc003nxr.3_5'Flank|NEU1_uc010jth.2_5'Flank|NEU1_uc003nxs.3_5'Flank	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	496	Cytoplasmic (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	CCATCCTTACCGGAGTGTGCGG	0.604000													8	266					0	0	6.4e-05	0	0
SLC44A4	80736	broad.mit.edu	37	6	31837018	31837019	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr6:31837018_31837019CC>AA	uc010jti.2	-	13	1212_1213	c.1146_1147GG>TT	c.(1144-1149)TCGGGG>TCTTGG	p.G383W		NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	383	Extracellular (Potential).			LATSGQPQ -> PLPTQPATLG (in Ref. 4; AAD21813 and 5; BAB63296).		integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	TGGGGTTGCCCCGATGTAGCCA	0.554000													12	497					0	0	6.4e-05	0	0
SLC44A4	80736	broad.mit.edu	37	6	31842556	31842557	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr6:31842556_31842557CC>AA	uc010jti.2	-	6	475_476	c.409_410GG>TT	c.(409-411)GGG>TTG	p.G137L	SLC44A4_uc011dol.1_Missense_Mutation_p.G61L|SLC44A4_uc011dom.1_Intron	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	137	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	GAAGACTTCCCCAACAGTCTGT	0.525000													13	599					0	0	6.4e-05	0	0
FKBPL	63943	broad.mit.edu	37	6	32097440	32097441	+	Silent	DNP	GG	TT	TT			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr6:32097440_32097441GG>TT	uc003nzr.2	-	2	387_388	c.117_118CC>AA	c.(115-120)CCCCGA>CCAAGA	p.39_40PR>PR	ATF6B_uc003nzo.2_5'Flank|ATF6B_uc003nzn.2_5'Flank|ATF6B_uc011dpg.1_5'Flank|ATF6B_uc011dph.1_5'Flank	NM_022110	NP_071393	Q9UIM3	FKBPL_HUMAN	WAF-1/CIP1 stabilizing protein 39	39_40					response to radiation	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0						GGAGGGTCTCGGGGCTGCTGCC	0.485000													13	646					0	0	6.4e-05	0	0
CRISP2	7180	broad.mit.edu	37	6	49665657	49665657	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr6:49665657G>A	uc003ozq.2	-	8	687	c.431C>T	c.(430-432)TCG>TTG	p.S144L	CRISP2_uc003ozl.2_Missense_Mutation_p.S144L|CRISP2_uc003ozn.2_Missense_Mutation_p.S144L|CRISP2_uc003ozr.2_Missense_Mutation_p.S144L|CRISP2_uc003ozo.2_Missense_Mutation_p.S144L|CRISP2_uc003ozm.2_Missense_Mutation_p.S144L|CRISP2_uc003ozp.2_Missense_Mutation_p.S144L	NM_001142408	NP_001135880	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2 precursor	144						extracellular space				skin(1)	1	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			CTGGTAAGTCGAGTACCAAAC	0.313000													38	62					0	0	0.000374591	0	0
VNN3	55350	broad.mit.edu	37	6	133055466	133055466	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr6:133055466C>T	uc003qdp.2	-	2	342	c.270G>A	c.(268-270)AGG>AGA	p.R90R	VNN3_uc010kfs.2_5'UTR|VNN3_uc011ecl.1_RNA|VNN3_uc011ecm.1_5'UTR|VNN3_uc011ecn.1_5'UTR|VNN3_uc010kfu.2_5'UTR|VNN3_uc010kfv.2_RNA|VNN3_uc010kfw.2_5'UTR|VNN3_uc010kfx.2_5'UTR|VNN3_uc010kfy.2_5'UTR|VNN3_uc010kfz.2_5'UTR	NM_078625	NP_523239			SubName: Full=PAGEL-beta;												0	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00242)|GBM - Glioblastoma multiforme(226;0.0168)		AAATGCTCTCCCTGGTGAAGA	0.428000													21	8					0	0	0.000175454	0	0
GRM1	2911	broad.mit.edu	37	6	146625858	146625858	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr6:146625858C>T	uc010khw.1	+	4	1532	c.1062C>T	c.(1060-1062)TTC>TTT	p.F354F	GRM1_uc010khv.1_Silent_p.F354F|GRM1_uc003qll.2_Silent_p.F354F|GRM1_uc011edz.1_Silent_p.F354F|GRM1_uc011eea.1_Silent_p.F354F	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	354	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	ATGATTATTTCCTGAAACTGA	0.498000													31	11					0	0	0.000279167	0	0
GCK	2645	broad.mit.edu	37	7	44189377	44189377	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr7:44189377C>T	uc003tkl.2	-	6	1131	c.661G>A	c.(661-663)GAG>AAG	p.E221K	GCK_uc003tkj.1_Missense_Mutation_p.E220K|GCK_uc003tkk.1_Missense_Mutation_p.E222K	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	221			E -> K (in MODY2).		cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						ATGCCGACCTCGCACTGATGG	0.567000													141	239					0	0	0.000147903	0	0
ABCB1	5243	broad.mit.edu	37	7	87144604	87144604	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr7:87144604C>T	uc003uiz.1	-	26	3643	c.3225G>A	c.(3223-3225)GGG>GGA	p.G1075G	ABCB1_uc011khc.1_Silent_p.G1011G	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	1075	Cytoplasmic (Potential).|ABC transporter 2.|ATP 2 (By similarity).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CTGTGCTCTTCCCACAGCCAC	0.572000													18	40					0	0	0.000566183	0	0
FBXL13	222235	broad.mit.edu	37	7	102518846	102518846	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr7:102518846C>T	uc003vaq.2	-	15	1867	c.1440G>A	c.(1438-1440)AGG>AGA	p.R480R	FBXL13_uc010liq.1_Intron|FBXL13_uc010lir.1_Silent_p.R480R|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Silent_p.R480R	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	480	LRR 10.										0						GCTCTCTTATCCTCATGCTTG	0.348000													36	47					0	0	0.000509022	0	0
PSMC2	5701	broad.mit.edu	37	7	103008169	103008169	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr7:103008169C>T	uc003vbs.2	+	11	1127	c.1057C>T	c.(1057-1059)CAC>TAC	p.H353Y	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Missense_Mutation_p.H216Y	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	353					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						GGGTCGGACCCACATATTTAA	0.333000													31	46					0	0	0.000279167	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138764565	138764565	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr7:138764565C>T	uc003vun.2	-	4	1510	c.1122G>A	c.(1120-1122)AAG>AAA	p.K374K	ZC3HAV1_uc003vuo.2_5'Flank|ZC3HAV1_uc003vup.2_Silent_p.K374K	NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	zinc finger antiviral protein isoform 1	374					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			ovary(1)	1						AAAACACAGTCTTTCTCCTGG	0.542000													53	67					0	0	0.000147903	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				20	51					0	0	0.000132079	0	0
NOS3	4846	broad.mit.edu	37	7	150707703	150707703	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr7:150707703G>A	uc003wif.2	+	22	3000	c.2704G>A	c.(2704-2706)GAG>AAG	p.E902K	NOS3_uc011kuy.1_Missense_Mutation_p.E696K	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	902	FAD-binding FR-type.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	ACGCTACGAGGAGTGGAAGTG	0.667000													4	8					0	0	1.23904e-05	0	0
TEX15	56154	broad.mit.edu	37	8	30705724	30705724	+	Silent	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr8:30705724G>A	uc003xil.2	-	1	810	c.810C>T	c.(808-810)ATC>ATT	p.I270I		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	270										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		CTATTGGACTGATTTTTGTTT	0.313000													43	14					0	0	0.000270559	0	0
UNC5D	137970	broad.mit.edu	37	8	35647892	35647892	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr8:35647892C>T	uc003xjr.1	+	17	3001	c.2673C>T	c.(2671-2673)TTC>TTT	p.F891F	UNC5D_uc003xjs.1_Silent_p.F886F|UNC5D_uc003xju.1_Silent_p.F467F	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	891	Death.|Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TATCTTATTTCGCTACACAAA	0.393000													41	55					0	0	0.000509022	0	0
DNAJC5B	85479	broad.mit.edu	37	8	66992777	66992777	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr8:66992777G>A	uc003xvs.1	+	5	790	c.499G>A	c.(499-501)GAA>AAA	p.E167K	DNAJC5B_uc003xvt.1_RNA	NM_033105	NP_149096	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	167					protein folding	membrane	heat shock protein binding|unfolded protein binding				0		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			GTCTGACATGGAAAAAGGTGG	0.507000													4	10					0	0	1.23904e-05	0	0
RDH10	157506	broad.mit.edu	37	8	74209497	74209497	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr8:74209497G>C	uc003xzi.2	+	2	618	c.358G>C	c.(358-360)GGG>CGG	p.G120R	RDH10_uc003xzj.2_5'UTR	NM_172037	NP_742034	Q8IZV5	RDH10_HUMAN	retinol dehydrogenase 10	120					retinal metabolic process|retinol metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|microsome	binding|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity				0	Breast(64;0.0954)		Epithelial(68;0.0105)|all cancers(69;0.0465)|BRCA - Breast invasive adenocarcinoma(89;0.0608)			CTGTGACGTGGGGAAGAGGGA	0.517000													3	77					0	0	6.4e-05	0	0
CHMP4C	92421	broad.mit.edu	37	8	82645023	82645023	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr8:82645023C>T	uc003ycl.2	+	1	336	c.162C>T	c.(160-162)GCC>GCT	p.A54A		NM_152284	NP_689497	Q96CF2	CHM4C_HUMAN	chromatin modifying protein 4C	54	Intramolecular interaction with C- terminus (By similarity).				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein binding			ovary(2)	2						TCGCCCTGGCCAAGAAGCACG	0.602000													13	14					0	0	0.000219431	0	0
DPY19L4	286148	broad.mit.edu	37	8	95795929	95795930	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr8:95795929_95795930GG>TT	uc003ygx.2	+	17	1871_1872	c.1747_1748GG>TT	c.(1747-1749)GGG>TTG	p.G583L		NM_181787	NP_861452	Q7Z388	D19L4_HUMAN	dpy-19-like 4	583						integral to membrane				ovary(2)	2	Breast(36;3.85e-06)					TGTGTTTGCAGGGAGTCCACAG	0.391000													11	576					0	0	6.4e-05	0	0
PGCP	10404	broad.mit.edu	37	8	97797463	97797463	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr8:97797463G>T	uc003yhw.2	+	2	504	c.338G>T	c.(337-339)TGG>TTG	p.W113L	PGCP_uc010mbe.2_Missense_Mutation_p.W113L	NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	113					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					ATACCCCACTGGGAGAGGGGA	0.498000													17	52					8.28177e-16	1.67456e-14	9.7654e-05	1	0
MATN2	4147	broad.mit.edu	37	8	99030221	99030222	+	Splice_Site	DNP	GG	TT	TT			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr8:99030221_99030222GG>TT	uc003yic.2	+	12	1928	c.1697_splice	c.e12-1	p.R566_splice	MATN2_uc010mbh.1_Splice_Site_p.R525_splice|MATN2_uc003yid.2_Splice_Site_p.R566_splice|MATN2_uc003yie.1_Splice_Site_p.R566_splice|MATN2_uc010mbi.1_Splice_Site_p.R399_splice|MATN2_uc010mbj.1_Splice_Site_p.R65_splice	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor							proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			CCTGTCTTCAGGGAAAGATGTC	0.470000													12	466					0	0	6.4e-05	0	0
EPPK1	83481	broad.mit.edu	37	8	144940332	144940333	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr8:144940332_144940333GG>AA	uc003zaa.1	-	2	15112_15113	c.15099_15100CC>TT	c.(15097-15102)TACCGG>TATTGG	p.R5034W		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	5034	Plectin 64.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TAGCCGCGCCGGTAGGCCACGT	0.688000													19	564					0	0	6.4e-05	0	0
GPAA1	8733	broad.mit.edu	37	8	145139185	145139185	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr8:145139185C>T	uc003zax.2	+	6	875	c.765C>T	c.(763-765)TTC>TTT	p.F255F	GPAA1_uc003zav.1_Silent_p.F133F|GPAA1_uc003zaw.1_Silent_p.F195F	NM_003801	NP_003792	O43292	GPAA1_HUMAN	glycosylphosphatidylinositol anchor attachment	255	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|protein complex assembly|protein retention in ER lumen	GPI-anchor transamidase complex	tubulin binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.02e-40)|all cancers(56;2.11e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCAATCTCTTCCAGACCTTCT	0.642000													57	47					0	0	0.000147903	0	0
RPL8	6132	broad.mit.edu	37	8	146017189	146017189	+	Silent	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr8:146017189G>A	uc003zeb.2	-	3	360	c.249C>T	c.(247-249)CAC>CAT	p.H83H	RPL8_uc003zdz.2_RNA|RPL8_uc003zea.2_Silent_p.H47H|RPL8_uc003zec.2_Silent_p.H83H|RPL8_uc010mgc.2_Silent_p.H83H	NM_033301	NP_150644	P62917	RL8_HUMAN	ribosomal protein L8	83					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	rRNA binding|structural constituent of ribosome				0	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;5.47e-39)|OV - Ovarian serous cystadenocarcinoma(54;6.38e-39)|all cancers(56;5.47e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.191)		ACTGGCCCGTGTGAATGCCCT	0.637000													103	55					0	0	0.000147903	0	0
Unknown	0	broad.mit.edu	37	9	78938053	78938053	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr9:78938053C>T	uc004akc.1	+	4	583	c.363C>T	c.(361-363)GTC>GTT	p.V121V						Homo sapiens cDNA FLJ16215 fis, clone CTONG2025610, moderately similar to PC6B.																		GCCACTGTGTCCCCTGCCATA	0.572000													13	2					0	0	0.000151284	0	0
FAM47A	158724	broad.mit.edu	37	X	34150006	34150007	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chrX:34150006_34150007GG>AA	uc004ddg.2	-	1	422_423	c.389_390CC>TT	c.(388-390)CCC>CTT	p.P130L		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	130										ovary(4)|central_nervous_system(1)	5						ACATGGCCAAGGGATGCTTGGC	0.559000													40	18					0	0	6.4e-05	0	0
CXorf22	170063	broad.mit.edu	37	X	35985897	35985897	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chrX:35985897C>T	uc004ddj.2	+	10	1821	c.1762C>T	c.(1762-1764)CCC>TCC	p.P588S	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	588										large_intestine(1)|lung(1)|ovary(1)	3						ATTAGCCTTTCCCAATGACCG	0.403000													13	4					0	0	0.000422831	0	0
IQSEC2	23096	broad.mit.edu	37	X	53279585	53279585	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chrX:53279585G>A	uc004dsd.2	-	5	2374	c.2173C>T	c.(2173-2175)CCG>TCG	p.P725S	IQSEC2_uc004dsc.2_Missense_Mutation_p.P520S	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	715					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3						CCGGTAGCCGGAGGCTCCCTT	0.572000													13	2					0	0	0.00010058	0	0
OTUD6A	139562	broad.mit.edu	37	X	69282557	69282557	+	Silent	SNP	G	A	A			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chrX:69282557G>A	uc004dxu.1	+	1	217	c.183G>A	c.(181-183)CAG>CAA	p.Q61Q		NM_207320	NP_997203	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	61										lung(1)|skin(1)	2						AGCACCGGCAGGAGCTGGAGA	0.557000													9	5					0	0	3.86212e-05	0	0
NHSL2	340527	broad.mit.edu	37	X	71358756	71358756	+	Missense_Mutation	SNP	G	A	A	rs138787811	byFrequency	TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chrX:71358756G>A	uc011mqa.1	+	6	1358	c.1358G>A	c.(1357-1359)GGG>GAG	p.G453E	NHSL2_uc004eak.1_Missense_Mutation_p.G87E|NHSL2_uc010nli.2_Missense_Mutation_p.G222E	NM_001013627	NP_001013649	Q5HYW2	NHSL2_HUMAN	NHS-like 2	453											0	Renal(35;0.156)					GGATGCAGTGGGTCAGCTGGC	0.557000													13	3					0	0	0.00010058	0	0
NAP1L2	4674	broad.mit.edu	37	X	72434151	72434151	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chrX:72434151C>T	uc004ebi.2	-	1	534	c.178G>A	c.(178-180)GAA>AAA	p.E60K	NAP1L2_uc011mqj.1_Intron	NM_021963	NP_068798	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	60					nucleosome assembly	chromatin assembly complex				lung(1)	1	Renal(35;0.156)					TCACCGTTTTCCCCTTCTTCC	0.582000													32	6					0	0	0.000279167	0	0
NOX1	27035	broad.mit.edu	37	X	100105231	100105231	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chrX:100105231C>T	uc004egj.2	-	9	1248	c.1042G>A	c.(1042-1044)GAA>AAA	p.E348K	NOX1_uc004egl.3_Missense_Mutation_p.E348K|NOX1_uc010nne.2_Missense_Mutation_p.E311K	NM_007052	NP_008983	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1 isoform long	348	FAD-binding FR-type.|Extracellular (Potential).				angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			ovary(1)	1						AAGAAATCTTCCTCTGGAGCA	0.468000													36	7					0	0	0.000191422	0	0
CDR1	1038	broad.mit.edu	37	X	139865915	139865915	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chrX:139865915C>T	uc004fbg.1	-	1	809	c.617G>A	c.(616-618)TGG>TAG	p.W206*	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	206	5.|5 X 6 AA approximate repeats.										0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				GGAAAAAATCCAGGTCTTCCA	0.448000													75	24					0	0	0.000147903	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995638	140995638	+	Silent	SNP	C	T	T			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chrX:140995638C>T	uc004fbt.2	+	4	2734	c.2448C>T	c.(2446-2448)TCC>TCT	p.S816S	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	816							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CTGTGAGCTCCTTCCCCTCCT	0.552000										HNSCC(15;0.026)			128	34					0	0	0.000147903	0	0
MAGEA12	4111	broad.mit.edu	37	X	151896231	151896231	+	RNA	SNP	A	G	G			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chrX:151896231A>G	uc004fgb.2	-	4		c.536T>C						P43365	MAGAC_HUMAN	Homo sapiens melanoma antigen family A, 12, mRNA (cDNA clone MGC:4914 IMAGE:3450217), complete cds.											skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GAGTGGCTGGATAGTGTTGGC	0.517000													7	17					0	0	0.000566183	0	0
CACNA1E	777	broad.mit.edu	37	1	181680102	181680103	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr1:181680102_181680103delAG	uc001gow.2	+	8	1233_1234	c.1068_1069delAG	c.(1066-1071)AAAGAGfs	p.K356fs	CACNA1E_uc009wxs.2_Frame_Shift_Del_p.K263fs	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	356_357	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						AATTTGCCAAAGAGAGAGAGAG	0.510													7	113	---	---	---	---					
HEATR5A	25938	broad.mit.edu	37	14	31852869	31852869	+	Frame_Shift_Del	DEL	G	-	-			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr14:31852869delG	uc001wrf.3	-	4	652	c.575delC	c.(574-576)ACAfs	p.T192fs	HEATR5A_uc010ami.2_Frame_Shift_Del_p.T90fs|HEATR5A_uc001wrg.1_Frame_Shift_Del_p.T74fs|HEATR5A_uc010tpk.1_Frame_Shift_Del_p.T485fs	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	479							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		CAAGAGTGGTGTTAGGTAGGA	0.473													77	120	---	---	---	---					
PNN	5411	broad.mit.edu	37	14	39646845	39646866	+	Frame_Shift_Del	DEL	AGAGACCTTATCCAGGATCAAA	-	-			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr14:39646845_39646866delAGAGACCTTATCCAGGATCAAA	uc001wuw.3	+	5	473_494	c.376_397delAGAGACCTTATCCAGGATCAAA	c.(376-399)AGAGACCTTATCCAGGATCAAAATfs	p.R126fs		NM_002687	NP_002678	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	126_133	Necessary for interaction with RNPS1.|Necessary for mediating alternative 5' splicing.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			ovary(1)	1	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		GCGCACACGTAGAGACCTTATCCAGGATCAAAATATGGATGA	0.401													27	140	---	---	---	---					
VRK2	7444	broad.mit.edu	37	2	58312026	58312026	+	Frame_Shift_Del	DEL	A	-	-			TCGA-D3-A3C6-06A-12D-A196-08	TCGA-D3-A3C6-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca68c70f-084b-4ecb-8a4d-3c09d20ac726	a101f798-16cc-46db-95d4-aa9850f9757e	g.chr2:58312026delA	uc002rzo.2	+	7	942	c.197delA	c.(196-198)GAAfs	p.E66fs	VRK2_uc010fcb.2_Frame_Shift_Del_p.E66fs|VRK2_uc002rzs.2_Frame_Shift_Del_p.E66fs|VRK2_uc002rzr.2_Frame_Shift_Del_p.E66fs|VRK2_uc010fcc.2_Intron|VRK2_uc002rzv.2_Frame_Shift_Del_p.E66fs|VRK2_uc010fcd.2_Frame_Shift_Del_p.E43fs|VRK2_uc002rzp.2_Frame_Shift_Del_p.E66fs|VRK2_uc010ypg.1_Frame_Shift_Del_p.E66fs|VRK2_uc002rzq.2_Frame_Shift_Del_p.E66fs|VRK2_uc002rzu.2_Frame_Shift_Del_p.E66fs|VRK2_uc002rzt.2_5'UTR|VRK2_uc010yph.1_5'Flank	NM_001130482	NP_001123954	Q86Y07	VRK2_HUMAN	vaccinia related kinase 2 isoform 2	66	Protein kinase.					integral to membrane	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1						GAATATCAAGAAAATGGCCCG	0.259													2	4	---	---	---	---					
