Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TMEM201	199953	broad.mit.edu	37	1	9657101	9657101	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:9657101C>T	uc001apz.2	+	3	431	c.419C>T	c.(418-420)CCC>CTC	p.P140L	TMEM201_uc001apy.2_Missense_Mutation_p.P140L	NM_001130924	NP_001124396	Q5SNT2	TM201_HUMAN	transmembrane protein 201 isoform 1	140						integral to membrane|nuclear inner membrane					0	all_lung(157;0.222)	all_epithelial(116;2.09e-14)|Renal(390;0.000469)|all_lung(118;0.000521)|Lung NSC(185;0.000744)|Colorectal(325;0.0062)|Breast(348;0.0157)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.5e-08)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|STAD - Stomach adenocarcinoma(132;0.00345)|READ - Rectum adenocarcinoma(331;0.0419)		GCCTTCGCTCCCCGCGAGGAG	0.672000													16	22					0	0	0.00229938	0	0
MTOR	2475	broad.mit.edu	37	1	11303281	11303281	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:11303281G>A	uc001asd.2	-	9	1423	c.1302C>T	c.(1300-1302)TTC>TTT	p.F434F		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	434					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						CCAGGGCTTGGAAGGCCGCTG	0.522000													21	58					0	0	0.00152264	0	0
AADACL3	126767	broad.mit.edu	37	1	12785271	12785271	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:12785271G>A	uc009vnn.1	+	4	594	c.361G>A	c.(361-363)GAT>AAT	p.D121N	AADACL3_uc001aug.1_Missense_Mutation_p.D51N	NM_001103170	NP_001096640	Q5VUY0	ADCL3_HUMAN	arylacetamide deacetylase-like 3 isoform 1	121							hydrolase activity				0	Ovarian(185;0.249)	Lung NSC(185;8.27e-05)|all_lung(284;9.47e-05)|Renal(390;0.000147)|Colorectal(325;0.000583)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		GAAGTCCCTGGATGCATATGG	0.512000													35	81					0	0	0.00428921	0	0
MST1P9	11223	broad.mit.edu	37	1	17087458	17087458	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:17087458C>T	uc010ock.1	-	2	207	c.207G>A	c.(205-207)ATG>ATA	p.M69I	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_5'Flank	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						ACCAGCAGTCCATTAAGGGCC	0.627000													7	124					0	0	0.000274275	0	0
DDOST	1650	broad.mit.edu	37	1	20980210	20980210	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:20980210C>T	uc001bdo.1	-	8	1046	c.903G>A	c.(901-903)AAG>AAA	p.K301K	DDOST_uc009vpw.1_Silent_p.K301K|DDOST_uc010odd.1_Silent_p.K100K|DDOST_uc010ode.1_Silent_p.K264K	NM_005216	NP_005207	P39656	OST48_HUMAN	dolichyl-diphosphooligosaccharide-protein	301	Lumenal (Potential).				innate immune response|post-translational protein modification|response to cytokine stimulus|T cell activation	integral to membrane|microsome|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding				0		all_lung(284;2.98e-05)|Lung NSC(340;3.25e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.17e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000141)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00046)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CACCCTCCTCCTTGAACACCC	0.597000													11	22					0	0	0.000673444	0	0
SRRM1	10250	broad.mit.edu	37	1	24996657	24996657	+	Silent	SNP	C	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:24996657C>A	uc001bjm.2	+	15	2475	c.2251C>A	c.(2251-2253)CGA>AGA	p.R751R	SRRM1_uc010oel.1_Silent_p.R763R|SRRM1_uc009vri.1_Silent_p.R680R	NM_005839	NP_005830	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	751	Pro-rich.|Ser-rich.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		CTCATCCTCCCGATCTGTCTC	0.532000													6	142					0.00198382	0.00683498	0.00198382	1	0
FGR	2268	broad.mit.edu	37	1	27939754	27939754	+	Missense_Mutation	SNP	T	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:27939754T>G	uc001boj.2	-	10	1503	c.1357A>C	c.(1357-1359)ACC>CCC	p.T453P	FGR_uc001boi.2_Missense_Mutation_p.T156P|FGR_uc001bok.2_Missense_Mutation_p.T453P|FGR_uc001bol.2_Missense_Mutation_p.T453P|FGR_uc001bom.2_Missense_Mutation_p.T453P	NM_005248	NP_005239	P09769	FGR_HUMAN	proto-oncogene tyrosine-protein kinase FGR	453	Protein kinase.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			skin(2)	2		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CGGCCCTTGGTGATGAGCTCA	0.602000													16	50					0	0	0.000566183	0	0
CLSPN	63967	broad.mit.edu	37	1	36230223	36230223	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:36230223G>A	uc001bzi.2	-	3	306	c.226C>T	c.(226-228)CCA>TCA	p.P76S	CLSPN_uc009vux.2_Missense_Mutation_p.P76S	NM_022111	NP_071394	Q9HAW4	CLSPN_HUMAN	claspin	76					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GTTTTCTCTGGAGAGGCATTT	0.373000													14	44					0	0	0.000566183	0	0
ELOVL1	64834	broad.mit.edu	37	1	43830677	43830677	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:43830677G>A	uc001ciz.2	-	5	483	c.240C>T	c.(238-240)TTC>TTT	p.F80F	ELOVL1_uc001cja.2_Silent_p.F80F|ELOVL1_uc001cjb.2_Silent_p.F80F|ELOVL1_uc001cjc.2_RNA|ELOVL1_uc010okh.1_Intron	NM_022821	NP_073732	Q9BW60	ELOV1_HUMAN	elongation of very long chain fatty acids-like	80	Helical; (Potential).				fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|sphingolipid biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	fatty acid elongase activity|protein binding				0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CCGACATCAGGAACTGGGAAG	0.577000													6	17					0	0	0.00116845	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47564867	47564867	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:47564867C>T	uc001cqu.1	+	8	981	c.978C>T	c.(976-978)ATC>ATT	p.I326I		NM_178134	NP_835235	Q86W10	CP4Z1_HUMAN	cytochrome P450 4Z1	326	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			skin(1)	1						TCTCCTGGATCCTTTACTGCT	0.478000													22	35					0	0	0.00229938	0	0
C1orf175	374977	broad.mit.edu	37	1	55138821	55138821	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:55138821G>A	uc010ooe.1	+	8	1981	c.1657G>A	c.(1657-1659)GAG>AAG	p.E553K	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_Missense_Mutation_p.E121K|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Missense_Mutation_p.E71K|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Missense_Mutation_p.E553K|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	553						integral to membrane	binding				0						CCTCTTTATCGAGGACCCCAC	0.398000													18	30					0	0	0.00152264	0	0
TMEM61	199964	broad.mit.edu	37	1	55452004	55452004	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:55452004G>A	uc001cyd.2	+	2	524	c.250G>A	c.(250-252)GGC>AGC	p.G84S		NM_182532	NP_872338	Q8N0U2	TMM61_HUMAN	transmembrane protein 61	84	Helical; (Potential).					integral to membrane					0						GCTGCTCATTGGCCTGCTGTG	0.652000													41	105					0	0	0.00170553	0	0
L1TD1	54596	broad.mit.edu	37	1	62675455	62675455	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:62675455G>A	uc001dae.3	+	4	1311	c.1009G>A	c.(1009-1011)GAT>AAT	p.D337N		NM_019079	NP_061952	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	337										ovary(1)|skin(1)	2						TAACTTTCAGGATAAAACCCT	0.294000													15	50					0	0	0.00244969	0	0
WDR78	79819	broad.mit.edu	37	1	67301341	67301341	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:67301341C>T	uc001dcx.2	-	11	1757	c.1701G>A	c.(1699-1701)CGG>CGA	p.R567R	WDR78_uc009waw.2_Silent_p.R313R|WDR78_uc009wax.2_Intron	NM_024763	NP_079039	Q5VTH9	WDR78_HUMAN	WD repeat domain 78 isoform 1	567	WD 1.									ovary(2)	2						TACTGTTGCTCCGTACATTGT	0.368000													23	54					0	0	0.00278032	0	0
TNNI3K	51086	broad.mit.edu	37	1	74701860	74701860	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:74701860G>A	uc001dgf.1	+	2	166	c.115G>A	c.(115-117)GAA>AAA	p.E39K	TNNI3K_uc001dgc.1_Missense_Mutation_p.E140K|TNNI3K_uc001dgd.2_Missense_Mutation_p.E140K|TNNI3K_uc001dge.1_Missense_Mutation_p.E140K	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	39	Potential.					cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						GCAGATCAAGGAAAAAGAACT	0.299000													37	77					0	0	0.00128727	0	0
TMEM56	148534	broad.mit.edu	37	1	95657412	95657412	+	Silent	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:95657412A>G	uc001drb.2	+	7	1071	c.780A>G	c.(778-780)GGA>GGG	p.G260G	RWDD3_uc001drd.3_Intron|uc001dre.1_Intron|TMEM56_uc001drc.2_Silent_p.G260G	NM_152487	NP_689700	Q96MV1	TMM56_HUMAN	transmembrane protein 56	260						integral to membrane					0		all_lung(203;0.0232)|Lung NSC(277;0.0739)		all cancers(265;0.133)		TTCAGAATGGAAAACTTGATT	0.363000													11	21					0	0	0.000673444	0	0
COL11A1	1301	broad.mit.edu	37	1	103461558	103461558	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:103461558G>A	uc001dul.2	-	27	2600	c.2282C>T	c.(2281-2283)CCC>CTC	p.P761L	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.P773L|COL11A1_uc001dun.2_Missense_Mutation_p.P722L|COL11A1_uc009weh.2_Missense_Mutation_p.P645L	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	761	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TACTCCCCGGGGGCCCGGGTA	0.378000													30	64					0	0	0.00283554	0	0
NTNG1	22854	broad.mit.edu	37	1	107691265	107691265	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:107691265C>T	uc001dvh.3	+	2	768	c.50C>T	c.(49-51)TCC>TTC	p.S17F	NTNG1_uc001dvf.3_Missense_Mutation_p.S17F|NTNG1_uc010out.1_Missense_Mutation_p.S17F|NTNG1_uc001dvc.3_Missense_Mutation_p.S17F|NTNG1_uc001dvd.1_Missense_Mutation_p.S17F	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	17					axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		GTTACGGTGTCCTCAGTGATG	0.423000													41	88					0	0	0.0025221	0	0
NTNG1	22854	broad.mit.edu	37	1	107937858	107937858	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:107937858C>T	uc001dvh.3	+	4	1688	c.970C>T	c.(970-972)CCA>TCA	p.P324S	NTNG1_uc001dvf.3_Missense_Mutation_p.P324S|NTNG1_uc010out.1_Missense_Mutation_p.P324S|NTNG1_uc001dvc.3_Missense_Mutation_p.P324S|NTNG1_uc001dvi.2_5'UTR|NTNG1_uc001dve.2_RNA|NTNG1_uc009wek.2_RNA|NTNG1_uc001dvg.2_RNA|NTNG1_uc009wem.2_5'UTR|NTNG1_uc001dvd.1_Missense_Mutation_p.P324S	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	324	Laminin EGF-like 1.				axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		CACTACAGGTCCAGACTGTGG	0.493000													48	106					0	0	0.00361006	0	0
FNDC7	163479	broad.mit.edu	37	1	109271474	109271474	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:109271474G>A	uc001dvx.2	+	8	1590	c.1590G>A	c.(1588-1590)CGG>CGA	p.R530R	FNDC7_uc010ova.1_Silent_p.R297R	NM_001144937	NP_001138409	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	531	Fibronectin type-III 6.					extracellular region				ovary(1)|skin(1)	2		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		AGGCAGGACGGAGCCTGCCCA	0.562000													14	36					0	0	0.00400662	0	0
SORT1	6272	broad.mit.edu	37	1	109857359	109857359	+	Silent	SNP	C	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:109857359C>A	uc001dxm.1	-	18	2341	c.2292G>T	c.(2290-2292)GTG>GTT	p.V764V	SORT1_uc010ovi.1_Silent_p.V627V	NM_002959	NP_002950	Q99523	SORT_HUMAN	sortilin 1 preproprotein	764	Helical; (Potential).				endocytosis|endosome to lysosome transport|endosome transport via multivesicular body sorting pathway|glucose import|Golgi to endosome transport|induction of apoptosis by extracellular signals|myotube differentiation|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|neuropeptide signaling pathway|ossification|plasma membrane to endosome transport|regulation of gene expression|response to insulin stimulus|vesicle organization	cell surface|coated pit|early endosome|endoplasmic reticulum membrane|endosome membrane|Golgi cisterna membrane|integral to membrane|lysosomal membrane|microsome|nuclear membrane|perinuclear region of cytoplasm|plasma membrane	enzyme binding|nerve growth factor binding|nerve growth factor receptor activity|neurotensin receptor activity, non-G-protein coupled			ovary(1)	1		all_epithelial(167;4.69e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0529)|Colorectal(144;0.142)|Epithelial(280;0.145)|Kidney(133;0.169)|all cancers(265;0.184)		GCATCAATCCCACGATGGCCA	0.423000													10	463					0.00136819	0.00474535	0.00136819	1	0
KCND3	3752	broad.mit.edu	37	1	112329723	112329723	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:112329723C>T	uc001ebu.1	-	3	1592	c.1112G>A	c.(1111-1113)GGA>GAA	p.G371E	KCND3_uc001ebv.1_Missense_Mutation_p.G371E	NM_004980	NP_004971	Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related	371	Selectivity filter (By similarity).					sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			ovary(2)|large_intestine(1)	3		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		CACCATGTCTCCGTATCTGAG	0.517000													16	51					0	0	0.00074312	0	0
DCLRE1B	64858	broad.mit.edu	37	1	114454751	114454751	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:114454751C>T	uc001eeg.2	+	4	1708	c.1537C>T	c.(1537-1539)CAG>TAG	p.Q513*	DCLRE1B_uc001eeh.2_Intron|DCLRE1B_uc001eei.2_Nonsense_Mutation_p.Q387*	NM_022836	NP_073747	Q9H816	DCR1B_HUMAN	DNA cross-link repair 1B (PSO2 homolog, S.	513					cell cycle checkpoint|DNA repair|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|telomeric loop formation	centrosome|chromosome, telomeric region|nucleus	5'-3' exonuclease activity|protein binding				0	Lung SC(450;0.184)	all_cancers(81;1.46e-05)|all_epithelial(167;2.42e-05)|all_lung(203;0.000353)|Lung NSC(69;0.000518)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAACTTTTTCCAGGCAGGGTA	0.483000								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					41	119					0	0	0.00361006	0	0
SIKE1	80143	broad.mit.edu	37	1	115323135	115323135	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:115323135G>A	uc001efo.3	-	1	174	c.94C>T	c.(94-96)CAG>TAG	p.Q32*	SIKE1_uc001efp.3_Nonsense_Mutation_p.Q32*	NM_025073	NP_079349	Q9BRV8	SIKE1_HUMAN	suppressor of IKK epsilon isoform 2	32						cytosol	protein binding				0						GCCGCCGACTGATCCACCAGC	0.657000													14	29					0	0	0.00244969	0	0
SPAG17	200162	broad.mit.edu	37	1	118624248	118624248	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:118624248C>T	uc001ehk.2	-	14	1848	c.1780G>A	c.(1780-1782)GAA>AAA	p.E594K		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	594						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CGTTCTACTTCATTCCAGCTC	0.458000													15	54					0	0	0.00316338	0	0
TBX15	6913	broad.mit.edu	37	1	119466105	119466105	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:119466105A>T	uc001ehl.1	-	5	812	c.497T>A	c.(496-498)TTT>TAT	p.F166Y		NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	272	T-box.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		AGTCTCAGGAAAGTTGAACGT	0.483000													18	32					0	0	0.00074312	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144852490	144852490	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:144852490G>A	uc001elw.3	-	44	7300	c.7009C>T	c.(7009-7011)CTA>TTA	p.L2337L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.L2231L|PDE4DIP_uc001elv.3_Silent_p.L1344L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	2337					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AGAGCCCTTAGGGATTTCACC	0.507000			T	PDGFRB	MPD								9	52					0	0	0.000673444	0	0
PDE4DIP	9659	broad.mit.edu	37	1	145075723	145075723	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:145075723G>A	uc001emh.2	-	1	357	c.140C>T	c.(139-141)CCG>CTG	p.P47L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elo.2_Missense_Mutation_p.P47L|PDE4DIP_uc001emk.2_Missense_Mutation_p.P47L	NM_022359	NP_071754	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	721					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TTCCCGGCTCGGGGTCTGCCG	0.716000			T	PDGFRB	MPD								10	99					0	0	0.000673444	0	0
NOTCH2NL	388677	broad.mit.edu	37	1	145273413	145273413	+	Silent	SNP	C	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:145273413C>A	uc001emn.3	+	3	637	c.267C>A	c.(265-267)ACC>ACA	p.T89T	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_5'UTR|NOTCH2NL_uc001emm.3_Silent_p.T89T|NOTCH2NL_uc001emo.2_Silent_p.T89T|NOTCH2NL_uc010oyh.1_RNA	NM_203458	NP_982283	Q7Z3S9	NT2NL_HUMAN	Notch homolog 2 N-terminal like protein	89	EGF-like 3.				cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			ovary(1)	1						GCCGGGATACCTATGAGTGCA	0.478000													18	850					0.000958276	0.00333473	0.000958276	1	0
RPRD2	23248	broad.mit.edu	37	1	150430042	150430042	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:150430042C>T	uc009wlr.2	+	8	1350	c.1149C>T	c.(1147-1149)ATC>ATT	p.I383I	RPRD2_uc010pcc.1_Silent_p.I357I|RPRD2_uc001eup.3_Silent_p.I357I	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	383							protein binding			ovary(1)	1						GGTCAAAAATCATTGGTATGT	0.393000													55	187					0	0	0.00361006	0	0
ECM1	1893	broad.mit.edu	37	1	150484121	150484121	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:150484121C>T	uc001eus.2	+	7	1096	c.897C>T	c.(895-897)TTC>TTT	p.F299F	ECM1_uc010pce.1_3'UTR|ECM1_uc010pcf.1_3'UTR|ECM1_uc001eut.2_Intron|ECM1_uc001euu.2_Silent_p.F328F|ECM1_uc001euv.2_Silent_p.F326F|ECM1_uc009wlu.2_Silent_p.F59F	NM_004425	NP_004416	Q16610	ECM1_HUMAN	extracellular matrix protein 1 isoform 1	299	2 X approximate repeats.|2.				angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			AGCTGCCTTTCCCTCCTGGGG	0.597000													13	42					0	0	0.00185496	0	0
ARNT	405	broad.mit.edu	37	1	150804825	150804825	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:150804825A>C	uc001evr.1	-	9	997	c.854T>G	c.(853-855)GTG>GGG	p.V285G	ARNT_uc001evs.1_Missense_Mutation_p.V270G|ARNT_uc009wmb.1_Missense_Mutation_p.V276G|ARNT_uc009wmc.1_Missense_Mutation_p.V285G|ARNT_uc009wmd.1_Missense_Mutation_p.V270G|ARNT_uc009wme.1_Missense_Mutation_p.V285G|ARNT_uc010pcl.1_Missense_Mutation_p.V269G	NM_001668	NP_001659	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	285					positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			skin(4)|lung(3)|central_nervous_system(1)|kidney(1)	9	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCTGTTCCTCACAAAGCTCAG	0.438000			T	ETV6	AML								26	134					0	0	0.001512	0	0
SETDB1	9869	broad.mit.edu	37	1	150902529	150902529	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:150902529C>T	uc001evu.2	+	3	537	c.347C>T	c.(346-348)TCT>TTT	p.S116F	SETDB1_uc009wmf.2_Missense_Mutation_p.S116F|SETDB1_uc001evv.2_Missense_Mutation_p.S116F|SETDB1_uc001evw.3_Missense_Mutation_p.S116F|SETDB1_uc009wmg.1_Missense_Mutation_p.S116F	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	116					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			GAGGACGAATCTTCCCGGCCT	0.448000													17	80					0	0	0.00074312	0	0
PGLYRP4	57115	broad.mit.edu	37	1	153309673	153309673	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:153309673G>A	uc001fbo.2	-	8	992	c.927C>T	c.(925-927)TTC>TTT	p.F309F	PGLYRP4_uc001fbp.2_Silent_p.F305F	NM_020393	NP_065126	Q96LB8	PGRP4_HUMAN	peptidoglycan recognition protein-I-beta	309					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)|skin(1)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			AGGTGCCCATGAAGGTAATGC	0.522000													16	71					0	0	0.000958276	0	0
SYT11	23208	broad.mit.edu	37	1	155838375	155838375	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:155838375C>T	uc001fmg.2	+	2	917	c.654C>T	c.(652-654)ACC>ACT	p.T218T	SYT11_uc010pgq.1_Intron	NM_152280	NP_689493	Q9BT88	SYT11_HUMAN	synaptotagmin XI	218	Cytoplasmic (Potential).|C2 1.					cell junction|synaptic vesicle membrane	protein binding|transporter activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			TGCGGAAGACCCTGGACCCTG	0.557000													12	49					0	0	0.000978159	0	0
ARHGEF2	9181	broad.mit.edu	37	1	155931590	155931590	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:155931590C>T	uc001fmt.2	-	11	1448	c.1330G>A	c.(1330-1332)GAG>AAG	p.E444K	ARHGEF2_uc001fmr.2_Missense_Mutation_p.E416K|ARHGEF2_uc001fms.2_Missense_Mutation_p.E443K|ARHGEF2_uc001fmu.2_Missense_Mutation_p.E488K|ARHGEF2_uc010pgt.1_Missense_Mutation_p.E417K|ARHGEF2_uc010pgu.1_Missense_Mutation_p.E489K	NM_001162383	NP_001155855	Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor 2	444					actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			ovary(1)	1	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					TTGTAGATCTCCTGCAGACGG	0.607000													24	93					0	0	0.00332997	0	0
OR10J1	26476	broad.mit.edu	37	1	159410507	159410507	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:159410507C>T	uc010piv.1	+	1	959	c.959C>T	c.(958-960)TCC>TTC	p.S320F	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	320	Cytoplasmic (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					GGGAAGTTTTCCTGACCATGT	0.493000													23	62					0	0	0.00278032	0	0
CRP	1401	broad.mit.edu	37	1	159683618	159683618	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:159683618G>A	uc001ftw.2	-	2	476	c.372C>T	c.(370-372)ATC>ATT	p.I124I	CRP_uc001ftx.1_Intron|CRP_uc001fty.1_RNA	NM_000567	NP_000558	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related precursor	124	Pentaxin.				acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	AGAACTCCACGATCCCTGAGG	0.522000													119	111					0	0	0.00361006	0	0
CCDC19	25790	broad.mit.edu	37	1	159846476	159846476	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:159846476C>T	uc001fui.2	-	10	1240	c.1222G>A	c.(1222-1224)GAA>AAA	p.E408K	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_Missense_Mutation_p.E323K|CCDC19_uc001ful.2_Missense_Mutation_p.E323K|CCDC19_uc009wtc.1_Missense_Mutation_p.G407E	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	408	Potential.					mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			CGCGCATTTTCCTTTTCCTTT	0.562000													21	45					0	0	0.00121646	0	0
TBX19	9095	broad.mit.edu	37	1	168260534	168260534	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:168260534C>T	uc001gfl.2	+	2	391	c.340C>T	c.(340-342)CCA>TCA	p.P114S	TBX19_uc001gfj.3_Missense_Mutation_p.P45S	NM_005149	NP_005140	O60806	TBX19_HUMAN	T-box 19	114	T-box.				anatomical structure morphogenesis	nucleus	DNA binding				0	all_hematologic(923;0.215)					CGCTGGCAAGCCAGAGGTCTC	0.587000													22	103					0	0	0.00106085	0	0
C1orf112	55732	broad.mit.edu	37	1	169790881	169790881	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:169790881C>T	uc001ggp.2	+	10	1074	c.764C>T	c.(763-765)TCC>TTC	p.S255F	C1orf112_uc001ggj.2_RNA|C1orf112_uc001ggq.2_Missense_Mutation_p.S255F|C1orf112_uc009wvt.2_5'UTR|C1orf112_uc010plu.1_Missense_Mutation_p.S226F|C1orf112_uc009wvu.1_Intron|C1orf112_uc001ggr.2_Missense_Mutation_p.S120F|C1orf112_uc010plv.1_Missense_Mutation_p.S197F	NM_018186	NP_060656	Q9NSG2	CA112_HUMAN	hypothetical protein LOC55732	255											0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTTGCCAACTCCCTTTTgcac	0.169000													21	42					0	0	0.00188189	0	0
FMO1	2326	broad.mit.edu	37	1	171254677	171254677	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:171254677C>T	uc009wvz.2	+	9	1729	c.1593C>T	c.(1591-1593)TTC>TTT	p.F531F	FMO1_uc010pme.1_Silent_p.F468F|FMO1_uc001ghl.2_Silent_p.F531F|FMO1_uc001ghm.2_Silent_p.F531F|FMO1_uc001ghn.2_3'UTR	NM_002021	NP_002012	Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	531					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTCTGATTTTCCTATAAGTAA	0.363000													14	30					0	0	0.00244969	0	0
METTL13	51603	broad.mit.edu	37	1	171761229	171761229	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:171761229C>T	uc001ghz.2	+	6	1894	c.1547C>T	c.(1546-1548)CCA>CTA	p.P516L	METTL13_uc001gia.2_Missense_Mutation_p.P430L|METTL13_uc001gib.2_Missense_Mutation_p.P360L|METTL13_uc010pml.1_Missense_Mutation_p.P515L|METTL13_uc001gic.1_5'Flank	NM_015935	NP_057019	Q8N6R0	MTL13_HUMAN	CGI-01 protein isoform 1	516							methyltransferase activity|protein binding			kidney(1)	1						GATCATTTTCCAAAGTCCTGC	0.522000													24	123					0	0	0.00395357	0	0
TNN	63923	broad.mit.edu	37	1	175097186	175097186	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:175097186G>A	uc001gkl.1	+	14	3177	c.3064G>A	c.(3064-3066)GAA>AAA	p.E1022K		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	1022	Fibronectin type-III 9.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GCTGGGACGGGAAGACCAGAG	0.552000													18	70					0	0	0.00074312	0	0
PAPPA2	60676	broad.mit.edu	37	1	176758969	176758969	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:176758969G>A	uc001gkz.2	+	18	5904	c.4740G>A	c.(4738-4740)CTG>CTA	p.L1580L	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1580	Sushi 3.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TACAATGCCTGGAAGGTGGAA	0.448000													18	7					0	0	0.000566183	0	0
ASTN1	460	broad.mit.edu	37	1	176852083	176852083	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:176852083G>A	uc001glc.2	-	20	3486	c.3274C>T	c.(3274-3276)CCT>TCT	p.P1092S	ASTN1_uc001glb.1_Missense_Mutation_p.P1092S|ASTN1_uc001gld.1_Missense_Mutation_p.P1092S	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	1100	Fibronectin type-III 1.				cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						ATTGCACAAGGAGACTTTGCT	0.493000													22	99					0	0	0.00229938	0	0
LAMC1	3915	broad.mit.edu	37	1	183083683	183083683	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:183083683C>T	uc001gpy.3	+	5	1296	c.1039C>T	c.(1039-1041)CGA>TGA	p.R347*		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	347	Laminin EGF-like 2.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTGCAATGGTCGATCCCAGGA	0.468000													35	282					0	0	0.00222228	0	0
RGS21	431704	broad.mit.edu	37	1	192335163	192335163	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:192335163C>T	uc001gsh.2	+	5	542	c.368C>T	c.(367-369)TCT>TTT	p.S123F		NM_001039152	NP_001034241	Q2M5E4	RGS21_HUMAN	regulator of G-protein signaling 21	123	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|skin(1)	2						GCCAAGGATTCTTTCCCTCGA	0.378000													23	110					0	0	0.00332997	0	0
KCNT2	343450	broad.mit.edu	37	1	196397273	196397273	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:196397273C>T	uc001gtd.1	-	10	1006	c.946G>A	c.(946-948)GAT>AAT	p.D316N	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.D316N|KCNT2_uc001gtf.1_Missense_Mutation_p.D316N|KCNT2_uc001gtg.1_Intron|KCNT2_uc009wyu.2_Missense_Mutation_p.D316N|KCNT2_uc009wyv.1_Missense_Mutation_p.D291N	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	316	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						TTTAAAAAATCCATAAGTAAA	0.378000													13	45					0	0	0.00185496	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204401437	204401437	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:204401437C>T	uc001haw.2	-	28	4525	c.4046G>A	c.(4045-4047)CGG>CAG	p.R1349Q	PIK3C2B_uc010pqv.1_Missense_Mutation_p.R1321Q	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	1349					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GAGGGTCAGCCGGTCATCTGA	0.527000													27	93					0	0	0.00106085	0	0
CR2	1380	broad.mit.edu	37	1	207643060	207643060	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:207643060C>T	uc001hfw.2	+	6	932	c.838C>T	c.(838-840)CCC>TCC	p.P280S	CR2_uc001hfv.2_Missense_Mutation_p.P280S|CR2_uc009xch.2_Missense_Mutation_p.P280S|CR2_uc009xci.1_5'Flank	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	280	Sushi 5.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						CCCATCACCTCCCCCTATTCT	0.433000													15	71					0	0	0.000566183	0	0
CR1	1378	broad.mit.edu	37	1	207751265	207751265	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:207751265G>A	uc001hfy.2	+	21	3443	c.3303G>A	c.(3301-3303)GGG>GGA	p.G1101G	CR1_uc009xcl.1_Silent_p.G651G|CR1_uc001hfx.2_Silent_p.G1551G	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1101	Extracellular (Potential).|Sushi 17.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						GAAGCAGAGGGAGAAAGGTGT	0.517000													94	123					0	0	0.00361006	0	0
CAMK1G	57172	broad.mit.edu	37	1	209785202	209785202	+	Silent	SNP	G	A	A	rs147599953	byFrequency	TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:209785202G>A	uc001hhd.2	+	11	1083	c.981G>A	c.(979-981)CCG>CCA	p.P327P	CAMK1G_uc001hhf.3_Silent_p.P327P|CAMK1G_uc001hhe.2_Silent_p.P327P	NM_020439	NP_065172	Q96NX5	KCC1G_HUMAN	calcium/calmodulin-dependent protein kinase IG	327						Golgi membrane|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0475)		TGCACAGCCCGGGCGTCCGCC	0.597000													26	89					0	0	0.00395357	0	0
SLC30A10	55532	broad.mit.edu	37	1	220089128	220089128	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:220089128C>T	uc001hlw.2	-	4	1332	c.1121G>A	c.(1120-1122)GGA>GAA	p.G374E	SLC30A10_uc001hlu.1_Intron|SLC30A10_uc001hlv.2_Missense_Mutation_p.G129E|SLC30A10_uc001hlx.2_Missense_Mutation_p.G149E	NM_018713	NP_061183	Q6XR72	ZNT10_HUMAN	solute carrier family 30 (zinc transporter),	374	Cytoplasmic (Potential).				zinc ion transport	integral to membrane|plasma membrane	cation transmembrane transporter activity				0				GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.209)		ATTGTGGATTCCCGCATGGTG	0.468000													71	81					0	0	0.00361006	0	0
DISP1	84976	broad.mit.edu	37	1	223178084	223178084	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:223178084C>T	uc001hnu.1	+	8	3492	c.3345C>T	c.(3343-3345)ATC>ATT	p.I1115I		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	1115	Helical; (Potential).				diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		TGATGCTCATCATGTGTATCA	0.542000													385	447					0	0	0.00361006	0	0
OBSCN	84033	broad.mit.edu	37	1	228494858	228494858	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:228494858C>T	uc009xez.1	+	45	12227	c.12183C>T	c.(12181-12183)CTC>CTT	p.L4061L	OBSCN_uc001hsn.2_Silent_p.L4061L	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4061	Ig-like 41.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TGGCCAGCCTCTCTGTCCGTG	0.632000													14	75					0	0	0.00400662	0	0
NID1	4811	broad.mit.edu	37	1	236175286	236175286	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:236175286G>A	uc001hxo.2	-	12	2564	c.2462C>T	c.(2461-2463)CCA>CTA	p.P821L	NID1_uc009xgd.2_Intron|NID1_uc009xgc.2_5'UTR	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	821	EGF-like 5; calcium-binding (Potential).				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GAAAGAGCCTGGAGTGTTGTA	0.552000													20	45					0	0	0.00229938	0	0
ACTN2	88	broad.mit.edu	37	1	236914939	236914940	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:236914939_236914940CC>TT	uc001hyf.2	+	15	2030_2031	c.1826_1827CC>TT	c.(1825-1827)ACC>ATT	p.T609I	ACTN2_uc001hyg.2_Missense_Mutation_p.T401I|ACTN2_uc009xgi.1_Missense_Mutation_p.T609I|ACTN2_uc010pxu.1_Missense_Mutation_p.T298I|ACTN2_uc001hyh.2_Missense_Mutation_p.T297I	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	609	Spectrin 3.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GAGCTCCGGACCAAGTGGGACA	0.564000													9	51					0	0	6.4e-05	0	0
ACTN2	88	broad.mit.edu	37	1	236923026	236923026	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:236923026G>A	uc001hyf.2	+	19	2508	c.2304G>A	c.(2302-2304)AGG>AGA	p.R768R	ACTN2_uc001hyg.2_Silent_p.R560R|ACTN2_uc009xgi.1_Silent_p.R768R|ACTN2_uc010pxu.1_Silent_p.R457R|ACTN2_uc001hyh.2_Silent_p.R456R	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	768	1; possibly ancestral.|EF-hand 1.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GCCAACAGAGGAAGAATGGCC	0.433000													40	56					0	0	0.00321405	0	0
NLRP3	114548	broad.mit.edu	37	1	247587607	247587607	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:247587607C>T	uc001icr.2	+	5	1000	c.862C>T	c.(862-864)CAC>TAC	p.H288Y	NLRP3_uc001ics.2_Missense_Mutation_p.H288Y|NLRP3_uc001icu.2_Missense_Mutation_p.H288Y|NLRP3_uc001icw.2_Missense_Mutation_p.H288Y|NLRP3_uc001icv.2_Missense_Mutation_p.H288Y|NLRP3_uc010pyw.1_Missense_Mutation_p.H286Y|NLRP3_uc001ict.1_Missense_Mutation_p.H286Y	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	288	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CCCACCCATCCACAAGATCGT	0.552000													33	53					0	0	0.00327116	0	0
OR2G3	81469	broad.mit.edu	37	1	247769793	247769793	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:247769793G>A	uc010pyz.1	+	1	906	c.906G>A	c.(904-906)AGG>AGA	p.R302R		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			AGGCTCTGAGGAAACTTCTCT	0.393000													34	62					0	0	0.000953801	0	0
OR13G1	441933	broad.mit.edu	37	1	247836218	247836218	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:247836218G>A	uc001idi.1	-	1	126	c.126C>T	c.(124-126)ATC>ATT	p.I42I		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	42	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TGGCAATGATGATGAGCATGT	0.423000													22	55					0	0	0.00229938	0	0
OR1C1	26188	broad.mit.edu	37	1	247921054	247921054	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:247921054C>T	uc010pza.1	-	1	655	c.655G>A	c.(655-657)GGA>AGA	p.G219R		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	219	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			AAGATAAGTCCATAAGATACG	0.483000													27	29					0	0	0.00209593	0	0
OR2M3	127062	broad.mit.edu	37	1	248366917	248366917	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:248366917C>T	uc010pzg.1	+	1	548	c.548C>T	c.(547-549)TCC>TTC	p.S183F		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GACTTCCCCTCCCTACTAATC	0.413000													125	119					0	0	0.00361006	0	0
OR2M4	26245	broad.mit.edu	37	1	248402764	248402764	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:248402764C>T	uc010pzh.1	+	1	534	c.534C>T	c.(532-534)TTC>TTT	p.F178F		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ATCACTTTTTCTGTGATGTTG	0.428000													50	90					0	0	0.00361006	0	0
OR2T33	391195	broad.mit.edu	37	1	248436915	248436915	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:248436915C>T	uc010pzi.1	-	1	202	c.202G>A	c.(202-204)GAC>AAC	p.D68N		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AGCATCATGTCCATGAGGGAA	0.552000													49	139					0	0	0.00361006	0	0
OR2T2	401992	broad.mit.edu	37	1	248616173	248616174	+	Missense_Mutation	DNP	CG	TT	TT			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:248616173_248616174CG>TT	uc001iek.1	+	1	75_76	c.75_76CG>TT	c.(73-78)CCCGGG>CCTTGG	p.G26W		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	26	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTGCCTTCCCCGGGCTTCTCTT	0.540000													44	304					0	0	6.4e-05	0	0
OR2G6	391211	broad.mit.edu	37	1	248685082	248685082	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:248685082C>T	uc001ien.1	+	1	135	c.135C>T	c.(133-135)CTC>CTT	p.L45L		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	45	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACACTGCCCTCATACTAGTAT	0.478000													40	49					0	0	0.000953801	0	0
ITGA8	8516	broad.mit.edu	37	10	15639298	15639298	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:15639298C>T	uc001ioc.1	-	21	2119	c.2119G>A	c.(2119-2121)GGA>AGA	p.G707R	ITGA8_uc010qcb.1_Missense_Mutation_p.G692R	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	707	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						GGTCGAAATCCCTACAATTGC	0.498000													22	31					0	0	0.00229938	0	0
PARD3	56288	broad.mit.edu	37	10	34400331	34400331	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:34400331G>A	uc010qej.1	-	25	3837	c.3837C>T	c.(3835-3837)GTC>GTT	p.V1279V	PARD3_uc010qek.1_Silent_p.V1276V|PARD3_uc010qel.1_Silent_p.V1242V|PARD3_uc010qem.1_Silent_p.V1263V|PARD3_uc010qen.1_Silent_p.V1233V|PARD3_uc010qeo.1_Silent_p.V1196V|PARD3_uc010qep.1_Silent_p.V1189V|PARD3_uc010qeq.1_Silent_p.V1167V|uc001ixe.1_5'Flank	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	1279					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				TTTCCAGCATGACCCTGGCGT	0.592000													14	29					0	0	0.000566183	0	0
FRMPD2	143162	broad.mit.edu	37	10	49386119	49386119	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:49386119C>T	uc001jgi.2	-	22	2973	c.2866G>A	c.(2866-2868)GAA>AAA	p.E956K	FRMPD2_uc001jgh.2_Missense_Mutation_p.E924K|FRMPD2_uc001jgj.2_Missense_Mutation_p.E934K|FRMPD2L1_uc001jgf.2_5'Flank|FRMPD2_uc001jgg.2_5'Flank|FRMPD2_uc001jgk.2_5'UTR	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	956	PDZ 2.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		GTCCCATCTTCTTTAACCAGT	0.428000													5	15					0	0	0.000274275	0	0
LRRC18	474354	broad.mit.edu	37	10	50122162	50122162	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:50122162G>A	uc001jhd.2	-	1	119	c.39C>T	c.(37-39)ATC>ATT	p.I13I	WDFY4_uc001jha.3_Intron|LRRC18_uc001jhe.1_Silent_p.I13I	NM_001006939	NP_001006940	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	13						cytoplasm				ovary(1)|pancreas(1)	2						CCTTGAGGGTGATCTTCTTGC	0.443000													21	36					0	0	0.00278032	0	0
SLC16A9	220963	broad.mit.edu	37	10	61443926	61443926	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:61443926C>T	uc010qig.1	-	2	573	c.124G>A	c.(124-126)GAT>AAT	p.D42N		NM_194298	NP_919274	Q7RTY1	MOT9_HUMAN	solute carrier family 16 (monocarboxylic acid	42	Cytoplasmic (Potential).				urate metabolic process	integral to membrane|plasma membrane	symporter activity			skin(2)|ovary(1)	3						CCAAAGGCATCCAGCCATTCT	0.478000													31	60					0	0	0.00428921	0	0
ANK3	288	broad.mit.edu	37	10	61830452	61830452	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:61830452G>T	uc001jky.2	-	37	10379	c.10187C>A	c.(10186-10188)TCC>TAC	p.S3396Y	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3396					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GGTGGCAATGGAACACTCTGT	0.468000													32	43					4.62619e-21	1.64005e-20	0.00428921	1	0
ANK3	288	broad.mit.edu	37	10	61868658	61868658	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:61868658G>A	uc001jky.2	-	27	3295	c.3103C>T	c.(3103-3105)CCC>TCC	p.P1035S	ANK3_uc001jkw.2_Missense_Mutation_p.P169S|ANK3_uc009xpa.2_Missense_Mutation_p.P169S|ANK3_uc001jkx.2_Missense_Mutation_p.P213S|ANK3_uc010qih.1_Missense_Mutation_p.P1036S|ANK3_uc001jkz.3_Missense_Mutation_p.P1029S|ANK3_uc001jla.1_Missense_Mutation_p.P101S|ANK3_uc001jlb.1_Missense_Mutation_p.P553S	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1035	ZU5.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding	p.P1035S(1)		skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TCCACCATGGGGGGTGGGTTG	0.502000													23	33					0	0	0.00278032	0	0
HERC4	26091	broad.mit.edu	37	10	69752044	69752044	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:69752044G>A	uc001jng.3	-	11	1494	c.1183C>T	c.(1183-1185)CCG>TCG	p.P395S	HERC4_uc009xpq.2_5'UTR|HERC4_uc001jnf.3_RNA|HERC4_uc001jnh.3_Missense_Mutation_p.P395S|HERC4_uc009xpr.2_Missense_Mutation_p.P395S|HERC4_uc001jni.3_Missense_Mutation_p.P139S|HERC4_uc001jnj.2_Missense_Mutation_p.P395S	NM_022079	NP_071362	Q5GLZ8	HERC4_HUMAN	hect domain and RLD 4 isoform a	395					cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			ovary(1)|breast(1)|skin(1)	3						TGCTTTGTCGGATTGGGACAT	0.393000													34	44					0	0	0.000953801	0	0
CYP2C9	1559	broad.mit.edu	37	10	96741125	96741125	+	Nonsense_Mutation	SNP	A	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:96741125A>T	uc001kka.3	+	7	1172	c.1147A>T	c.(1147-1149)AAG>TAG	p.K383*	CYP2C9_uc009xut.2_Nonsense_Mutation_p.K381*	NM_000771	NP_000762	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C,	383					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(4)|ovary(2)	6		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	TCTCATTCCCAAGGTAAGTTT	0.458000													16	43					0	0	0.00400662	0	0
NRAP	4892	broad.mit.edu	37	10	115365969	115365969	+	Silent	SNP	G	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:115365969G>T	uc001laj.2	-	33	3939	c.3775C>A	c.(3775-3777)CGA>AGA	p.R1259R	NRAP_uc009xyb.2_Intron|NRAP_uc001lak.2_Silent_p.R1224R|NRAP_uc001lal.3_Silent_p.R1259R	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	1259	Nebulin 33.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		GTTTTTGCTCGGATGAACTCG	0.433000													6	54					0.00198382	0.00683498	0.00198382	1	0
C10orf96	374355	broad.mit.edu	37	10	118137974	118137974	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:118137974G>A	uc001lck.2	+	8	944	c.693G>A	c.(691-693)ATG>ATA	p.M231I		NM_198515	NP_940917	P0C7W6	CJ096_HUMAN	hypothetical protein LOC374355	231	Potential.									ovary(2)	2		Lung NSC(174;0.204)|all_lung(145;0.248)		all cancers(201;0.014)		AAGATGACATGGAAAGTGTTT	0.274000													25	28					0	0	0.00127121	0	0
PNLIPRP1	5407	broad.mit.edu	37	10	118365033	118365033	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:118365033G>A	uc001lco.1	+	12	1326	c.1308G>A	c.(1306-1308)AAG>AAA	p.K436K	PNLIPRP1_uc001lcp.2_Silent_p.K436K	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	436	PLAT.				lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		GTGCCACCAAGATCACTGTGC	0.413000													10	22					0	0	0.000978159	0	0
TUBGCP2	10844	broad.mit.edu	37	10	135099033	135099033	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:135099033G>A	uc001lmg.1	-	12	2179	c.1822C>T	c.(1822-1824)CTG>TTG	p.L608L	TUBGCP2_uc001lmf.1_Silent_p.L201L|TUBGCP2_uc010qvc.1_Silent_p.L636L|TUBGCP2_uc009ybk.1_Intron|TUBGCP2_uc010qvd.1_Silent_p.L478L|TUBGCP2_uc001lmh.1_RNA	NM_006659	NP_006650	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	608					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		CTCAGCGCCAGCTCCGTGGGG	0.637000													6	19					0	0	0.00116845	0	0
SIGIRR	59307	broad.mit.edu	37	11	408110	408110	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:408110C>T	uc001lpd.2	-	4	633	c.303G>A	c.(301-303)CAG>CAA	p.Q101Q	SIGIRR_uc001lpf.2_Silent_p.Q101Q|SIGIRR_uc001lpe.1_Silent_p.Q101Q|SIGIRR_uc001lpg.2_Silent_p.Q101Q	NM_001135054	NP_001128526	Q6IA17	SIGIR_HUMAN	single Ig IL-1R-related molecule	101	Ig-like C2-type.|Extracellular (Potential).				acute-phase response|innate immune response|negative regulation of chemokine biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity	integral to membrane	protein binding|transmembrane receptor activity				0		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGCTGATGTTCTGGATGGAGC	0.582000													14	76					0	0	0.00316338	0	0
OR52M1	119772	broad.mit.edu	37	11	4567252	4567252	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:4567252C>T	uc010qyf.1	+	1	832	c.832C>T	c.(832-834)CTG>TTG	p.L278L		NM_001004137	NP_001004137	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M,	278	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGTCCACACTCTGCTGGCCAA	0.498000													10	41					0	0	0.000442599	0	0
OR51F2	119694	broad.mit.edu	37	11	4842792	4842792	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:4842792C>T	uc010qyn.1	+	1	177	c.177C>T	c.(175-177)ATC>ATT	p.I59I		NM_001004753	NP_001004753	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F,	59	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATAGCATGATCCTGTTTGTGG	0.488000													16	153					0	0	0.000566183	0	0
OR52D1	390066	broad.mit.edu	37	11	5510608	5510608	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:5510608C>T	uc010qzg.1	+	1	672	c.672C>T	c.(670-672)ATC>ATT	p.I224I	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005163	NP_001005163	Q9H346	O52D1_HUMAN	olfactory receptor, family 52, subfamily D,	224	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.46e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGGCTTTATCCTCCATGCAG	0.488000													26	138					0	0	0.00127121	0	0
OR6A2	8590	broad.mit.edu	37	11	6816899	6816899	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:6816899A>G	uc001mes.1	-	1	241	c.41T>C	c.(40-42)GTG>GCG	p.V14A		NM_003696	NP_003687	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GCCCAGCAACACAAACTCACT	0.507000													12	45					0	0	0.00185496	0	0
ZNF215	7762	broad.mit.edu	37	11	6977047	6977047	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:6977047G>A	uc001mey.2	+	7	1427	c.839G>A	c.(838-840)TGG>TAG	p.W280*	ZNF215_uc010raw.1_3'UTR|ZNF215_uc010rax.1_Nonsense_Mutation_p.W42*|ZNF215_uc001mez.1_Intron	NM_013250	NP_037382	Q9UL58	ZN215_HUMAN	zinc finger protein 215	280					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		CAGAAAAAATGGGACATAAAT	0.378000													37	60					0	0	0.00111076	0	0
NLRP14	338323	broad.mit.edu	37	11	7063998	7063998	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:7063998C>T	uc001mfb.1	+	4	1064	c.741C>T	c.(739-741)ATC>ATT	p.I247I		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	247	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TTGAAGAAATCATGTACCAGC	0.433000													19	53					0	0	0.00121646	0	0
AMPD3	272	broad.mit.edu	37	11	10500204	10500204	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:10500204C>T	uc001mio.1	+	3	688	c.353C>T	c.(352-354)TCC>TTC	p.S118F	AMPD3_uc010rbz.1_Intron|AMPD3_uc001min.1_Missense_Mutation_p.S127F|AMPD3_uc009yfw.1_RNA|AMPD3_uc009yfx.1_Missense_Mutation_p.S118F|AMPD3_uc009yfz.2_RNA|AMPD3_uc001mip.1_Missense_Mutation_p.S125F|AMPD3_uc009yfy.2_Missense_Mutation_p.S118F	NM_001025389	NP_001020560	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3 isoform 1B	118					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		GGAGCCACTTCCCTGCCCACG	0.617000													33	51					0	0	0.00428921	0	0
USH1C	10083	broad.mit.edu	37	11	17542914	17542914	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:17542914C>T	uc001mnf.2	-	13	1173	c.1064G>A	c.(1063-1065)AGA>AAA	p.R355K	USH1C_uc001mne.2_Missense_Mutation_p.R355K|USH1C_uc009yhb.2_Missense_Mutation_p.R336K|USH1C_uc001mng.2_RNA|USH1C_uc001mnd.2_Missense_Mutation_p.R319K	NM_005709	NP_005700	Q9Y6N9	USH1C_HUMAN	harmonin isoform a	355	Potential.				equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1						CTTCCGGTATCTCTCATTTTC	0.502000													39	76					0	0	0.00195071	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955401	18955401	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:18955401C>T	uc001mpg.2	-	1	1149	c.931G>A	c.(931-933)GAA>AAA	p.E311K		NM_147199	NP_671732	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	311	Cytoplasmic (Potential).			EEI -> QET (in Ref. 2; AAL86880).	acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(2)|central_nervous_system(1)	3						TCCAGGATTTCCTCAGGAAGC	0.567000													9	50					0	0	0.000274275	0	0
NAV2	89797	broad.mit.edu	37	11	19955287	19955287	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:19955287G>A	uc010rdm.1	+	8	1927	c.1566G>A	c.(1564-1566)GAG>GAA	p.E522E	NAV2_uc001mpp.2_Silent_p.E435E|NAV2_uc001mpr.3_Silent_p.E499E	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	522	Potential.					nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						aggataaggagaaaagcaagg	0.393000													7	41					0	0	0.00198382	0	0
F2	2147	broad.mit.edu	37	11	46750326	46750326	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:46750326C>T	uc001ndf.3	+	11	1454	c.1411C>T	c.(1411-1413)CCT>TCT	p.P471S	F2_uc001ndg.3_RNA	NM_000506	NP_000497	P00734	THRB_HUMAN	coagulation factor II preproprotein	471	Peptidase S1.				activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity	p.P471S(1)		ovary(3)	3		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)	GCTGAAGAAGCCTGTTGCCTT	0.493000													12	60					0	0	0.00185496	0	0
OR4A16	81327	broad.mit.edu	37	11	55110948	55110948	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:55110948C>T	uc010rie.1	+	1	272	c.272C>T	c.(271-273)TCC>TTC	p.S91F		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	91	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						ATCGCTATTTCCTTGTCAGCT	0.438000													62	94					0	0	0.00361006	0	0
OR4S2	219431	broad.mit.edu	37	11	55418857	55418857	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:55418857C>T	uc001nhs.1	+	1	478	c.478C>T	c.(478-480)CTG>TTG	p.L160L		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	160	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				CCAAGTGGCTCTGGTAGTCCA	0.433000													63	37					0	0	0.00361006	0	0
OR5D18	219438	broad.mit.edu	37	11	55587319	55587319	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:55587319T>A	uc010rin.1	+	1	214	c.214T>A	c.(214-216)TTC>ATC	p.F72I		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	72	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				CTTTGTGGATTTCTGCTATTC	0.408000													56	107					0	0	0.00361006	0	0
OR5M8	219484	broad.mit.edu	37	11	56258182	56258182	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:56258182G>T	uc001nix.1	-	1	665	c.665C>A	c.(664-666)CCT>CAT	p.P222H		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					TAAAATAGCAGGGAAAATGTA	0.408000													12	29					1.49906e-05	5.25175e-05	0.00244969	1	0
OR5M1	390168	broad.mit.edu	37	11	56380724	56380724	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:56380724G>A	uc001nja.1	-	1	255	c.255C>T	c.(253-255)TTC>TTT	p.F85F		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	85	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						GTTCTGAGAGGAAATTGTGCA	0.448000													10	70					0	0	0.000442599	0	0
OR5B3	441608	broad.mit.edu	37	11	58170745	58170745	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:58170745C>T	uc010rkf.1	-	1	138	c.138G>A	c.(136-138)TTG>TTA	p.L46L		NM_001005469	NP_001005469	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B,	46	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CCCAGAATATCAATACAATAA	0.418000													23	29					0	0	0.000720815	0	0
ASRGL1	80150	broad.mit.edu	37	11	62124474	62124474	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:62124474C>T	uc001nte.3	+	4	633	c.349C>T	c.(349-351)CTG>TTG	p.L117L	ASRGL1_uc001ntf.3_Silent_p.L117L|ASRGL1_uc001ntg.3_5'UTR|ASRGL1_uc001nth.1_RNA	NM_025080	NP_079356	Q7L266	ASGL1_HUMAN	asparaginase-like 1	117					asparagine catabolic process via L-aspartate|protein maturation	cytoplasm|microtubule cytoskeleton|nucleus	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity				0					L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)	TCATTGCTTTCTGACTGACCA	0.398000													19	38					0	0	0.00278032	0	0
SLC22A8	9376	broad.mit.edu	37	11	62760988	62760988	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:62760988C>T	uc001nwo.2	-	10	1573	c.1437G>A	c.(1435-1437)GGG>GGA	p.G479G	SLC22A8_uc001nwn.1_3'UTR|SLC22A8_uc001nwp.2_Silent_p.G479G|SLC22A8_uc009yom.2_Silent_p.G356G|SLC22A8_uc010rmm.1_Silent_p.G388G|SLC22A8_uc009yon.2_Silent_p.G479G	NM_004254	NP_004245	Q8TCC7	S22A8_HUMAN	solute carrier family 22 member 8	479	Helical; (Potential).			YGI -> FTGS (in Ref. 1; AAD19357).	response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			skin(2)|ovary(1)	3						GGGCGGTGATCCCGTAGATGA	0.582000													11	54					0	0	0.00185496	0	0
ANKRD13D	338692	broad.mit.edu	37	11	67059550	67059550	+	Silent	SNP	A	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:67059550A>T	uc001okc.1	+	7	880	c.369A>T	c.(367-369)ACA>ACT	p.T123T	ANKRD13D_uc001okd.1_Silent_p.T210T|ANKRD13D_uc001oke.1_Silent_p.T123T	NM_207354	NP_997237	Q6ZTN6	AN13D_HUMAN	ankyrin repeat domain 13 family, member D	123										ovary(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			AGCCCGAAACACTGCTGGCCG	0.637000													17	41					0	0	0.00074312	0	0
LRP5	4041	broad.mit.edu	37	11	68153959	68153959	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:68153959C>T	uc001ont.2	+	6	1266	c.1191C>T	c.(1189-1191)ATC>ATT	p.I397I	LRP5_uc009ysg.2_5'UTR	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	397	LDL-receptor class B 6.|Beta-propeller 2.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						TGCGGGCCATCCGCAGGGCGT	0.637000													8	44					0	0	0.00307968	0	0
P2RY2	5029	broad.mit.edu	37	11	72946179	72946179	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:72946179C>T	uc001otj.2	+	3	1308	c.975C>T	c.(973-975)GGC>GGT	p.G325G	P2RY2_uc001otk.2_Silent_p.G325G|P2RY2_uc001otl.2_Silent_p.G325G	NM_002564	NP_002555	P41231	P2RY2_HUMAN	purinergic receptor P2Y2	325	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(1)|skin(1)	4					Suramin(DB04786)	CACCCACTGGCCCCAGCCCTG	0.642000													7	28					0	0	0.000274275	0	0
INTS4	92105	broad.mit.edu	37	11	77614629	77614629	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:77614629A>G	uc001oys.2	-	17	2082	c.2054T>C	c.(2053-2055)TTG>TCG	p.L685S	C11orf67_uc001oyp.2_Intron|INTS4_uc001oyt.2_RNA	NM_033547	NP_291025	Q96HW7	INT4_HUMAN	integrator complex subunit 4	685					snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			CTTCAAATACAAAGGGGCAGC	0.478000													3	44					0	0	6.4e-05	0	0
NAALAD2	10003	broad.mit.edu	37	11	89911136	89911136	+	Missense_Mutation	SNP	G	A	A	rs150474449		TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:89911136G>A	uc001pdf.3	+	16	1818	c.1709G>A	c.(1708-1710)CGA>CAA	p.R570Q	NAALAD2_uc009yvx.2_Missense_Mutation_p.R537Q|NAALAD2_uc009yvy.2_Intron	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	570	Extracellular (Potential).|NAALADase.				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				GCTCAATTACGAGGAGCACTG	0.348000													12	36					0	0	0.00136819	0	0
FAT3	120114	broad.mit.edu	37	11	92531999	92531999	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:92531999C>T	uc001pdj.3	+	9	5837	c.5820C>T	c.(5818-5820)ACC>ACT	p.T1940T		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1940	Cadherin 17.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GAGTACTTACCATAAAAAACA	0.423000										TCGA Ovarian(4;0.039)			145	271					0	0	0.00361006	0	0
MMP3	4314	broad.mit.edu	37	11	102710983	102710983	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:102710983C>T	uc001phj.1	-	6	856	c.791G>A	c.(790-792)GGA>GAA	p.G264E		NM_002422	NP_002413	P08254	MMP3_HUMAN	matrix metalloproteinase 3 preproprotein	264					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			lung(1)|kidney(1)	2		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	AGGGGGAGGTCCTAAAGGGAA	0.483000													8	29					0	0	0.00307968	0	0
GRIA4	2893	broad.mit.edu	37	11	105483100	105483100	+	Silent	SNP	T	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:105483100T>C	uc001pix.2	+	3	632	c.186T>C	c.(184-186)TTT>TTC	p.F62F	GRIA4_uc001piu.1_Silent_p.F62F|GRIA4_uc001piw.2_Silent_p.F62F|GRIA4_uc001piv.2_Silent_p.F62F|GRIA4_uc009yxk.1_Silent_p.F62F|GRIA4_uc001pit.2_Silent_p.F62F	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	62	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	AAGCTCCTTTTAATTTGGTAC	0.398000													31	47					0	0	0.00428921	0	0
CUL5	8065	broad.mit.edu	37	11	107965615	107965615	+	Silent	SNP	T	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:107965615T>A	uc001pjv.2	+	15	2311	c.1644T>A	c.(1642-1644)CCT>CCA	p.P548P	CUL5_uc001pju.2_RNA	NM_003478	NP_003469	Q93034	CUL5_HUMAN	Vasopressin-activated calcium-mobilizing	548					cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			ovary(1)	1		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)		TCTCACTTCCTACTGAACTGG	0.358000													8	52					0	0	0.000274275	0	0
ATM	472	broad.mit.edu	37	11	108213955	108213955	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:108213955C>T	uc001pkb.1	+	57	8660	c.8275C>T	c.(8275-8277)CCC>TCC	p.P2759S	ATM_uc009yxr.1_Missense_Mutation_p.P2759S|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.P1411S	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2759	PI3K/PI4K.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		CCAGGTGGTTCCCCTCTCTCA	0.388000			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			44	70					0	0	0.00361006	0	0
DDX10	1662	broad.mit.edu	37	11	108594053	108594053	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:108594053C>T	uc001pkm.2	+	13	1894	c.1829C>T	c.(1828-1830)ACC>ATC	p.T610I	DDX10_uc001pkl.1_Missense_Mutation_p.T610I	NM_004398	NP_004389	Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	610							ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity	p.E594_E618del(1)		breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		CTTCCTAACACCAGTGAGGCA	0.368000			T	NUP98	AML*								16	21					0	0	0.000958276	0	0
TMPRSS13	84000	broad.mit.edu	37	11	117779432	117779432	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:117779432C>T	uc001prs.1	-	9	1270	c.1177G>A	c.(1177-1179)GAG>AAG	p.E393K	TMPRSS13_uc009yzr.1_Missense_Mutation_p.E72K|TMPRSS13_uc001prt.1_Missense_Mutation_p.E72K|TMPRSS13_uc001pru.1_Missense_Mutation_p.E393K	NM_001077263	NP_001070731	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	388	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			pancreas(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		GAGGCTGCCTCAGGCAACTGG	0.597000													4	18					0	0	0.00198382	0	0
AMICA1	120425	broad.mit.edu	37	11	118076638	118076638	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:118076638C>T	uc001psk.2	-	5	667	c.493G>A	c.(493-495)GTG>ATG	p.V165M	AMICA1_uc001psg.2_5'Flank|AMICA1_uc001psh.2_Missense_Mutation_p.V126M|AMICA1_uc009yzw.1_RNA|AMICA1_uc001psi.2_Missense_Mutation_p.V155M|AMICA1_uc001psj.2_Missense_Mutation_p.V165M|AMICA1_uc010rxw.1_Missense_Mutation_p.V126M|AMICA1_uc010rxx.1_Missense_Mutation_p.V165M|AMICA1_uc001psl.1_Missense_Mutation_p.V121M	NM_001098526	NP_001091996	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen	165	Ig-like V-type 2.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				ovary(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		ACCTTGGTCACGTGTTTCACT	0.458000													35	98					0	0	0.00195071	0	0
MLL	4297	broad.mit.edu	37	11	118390453	118390453	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:118390453C>T	uc001pta.2	+	32	11281	c.11258C>T	c.(11257-11259)GCC>GTC	p.A3753V	MLL_uc001ptb.2_Missense_Mutation_p.A3756V	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3753					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CCAGAGGAGGCCAATGAACCC	0.517000			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								22	52					0	0	0.00278032	0	0
TECTA	7007	broad.mit.edu	37	11	121008698	121008698	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:121008698C>T	uc010rzo.1	+	10	3510	c.3510C>T	c.(3508-3510)ATC>ATT	p.I1170I		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1170	VWFD 3.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GCTACAGCATCGTGATCCACC	0.562000													10	23					0	0	0.000673444	0	0
SORL1	6653	broad.mit.edu	37	11	121424794	121424794	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:121424794C>T	uc001pxx.2	+	17	2495	c.2415C>T	c.(2413-2415)TCC>TCT	p.S805S		NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	805	Extracellular (Potential).|LDL-receptor class B 1.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TGTATTGGTCCGACCTGGCCT	0.587000													16	17					0	0	0.000566183	0	0
OR10G4	390264	broad.mit.edu	37	11	123887211	123887211	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:123887211G>A	uc010sac.1	+	1	930	c.930G>A	c.(928-930)AGG>AGA	p.R310R		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	310	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		ATCCTCAGAGGAAATAAATAC	0.348000													11	29					0	0	0.00121646	0	0
KCNJ1	3758	broad.mit.edu	37	11	128709568	128709568	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:128709568G>A	uc001qeo.1	-	2	679	c.628C>T	c.(628-630)CTA>TTA	p.L210L	KCNJ1_uc001qep.1_Silent_p.L191L|KCNJ1_uc001qeq.1_Silent_p.L191L|KCNJ1_uc001qer.1_Silent_p.L191L|KCNJ1_uc001qes.1_Silent_p.L191L	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	210	Cytoplasmic (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	ACTCGGATTAGGAGGCAAAGC	0.488000													25	96					0	0	0.00278032	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130332616	130332616	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:130332616G>A	uc010scd.1	+	4	1483	c.1483G>A	c.(1483-1485)GAG>AAG	p.E495K		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	495	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		CAGCTGTGGCGAGGGCAAGCT	0.642000													24	63					0	0	0.000878237	0	0
SLC6A13	6540	broad.mit.edu	37	12	344336	344336	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:344336G>A	uc001qic.1	-	7	804	c.751C>T	c.(751-753)CGA>TGA	p.R251*	SLC6A13_uc009zdj.1_Nonsense_Mutation_p.R251*|SLC6A13_uc010sdl.1_Nonsense_Mutation_p.R159*|SLC6A13_uc010sdm.1_Nonsense_Mutation_p.R132*	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	251	Helical; Name=5; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			GTCACCCCTCGAATTAACAGG	0.537000													14	21					0	0	0.00185496	0	0
KCNA6	3742	broad.mit.edu	37	12	4920465	4920466	+	Missense_Mutation	DNP	AT	TG	TG			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:4920465_4920466AT>TG	uc001qng.2	+	1	2124_2125	c.1258_1259AT>TG	c.(1258-1260)ATG>TGG	p.M420W		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	420						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						AGTGGTTACAATGACCACGGTA	0.584000										HNSCC(72;0.22)			33	68					0	0	6.4e-05	0	0
NTF3	4908	broad.mit.edu	37	12	5603469	5603469	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:5603469C>T	uc001qnl.3	+	1	172	c.89C>T	c.(88-90)TCG>TTG	p.S30L	NTF3_uc001qnk.3_Missense_Mutation_p.S43L	NM_002527	NP_002518	P20783	NTF3_HUMAN	neurotrophin 3 isoform 2 preproprotein	30					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			pancreas(1)	1						CCAGAAGACTCGCTCAATTCC	0.428000													28	70					0	0	0.00127121	0	0
VWF	7450	broad.mit.edu	37	12	6103617	6103617	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:6103617G>A	uc001qnn.1	-	36	6470	c.6220C>T	c.(6220-6222)CCC>TCC	p.P2074S	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2074	VWFD 4.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	AAAGTCTTGGGGCTGAGCTGC	0.428000													39	112					0	0	0.00222228	0	0
CD163L1	283316	broad.mit.edu	37	12	7531810	7531810	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:7531810C>T	uc001qsy.2	-	9	2161	c.2135G>A	c.(2134-2136)GGA>GAA	p.G712E	CD163L1_uc010sge.1_Missense_Mutation_p.G722E	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	712	SRCR 7.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						ACACAGAATTCCCACGGCACC	0.502000													27	49					0	0	0.00106085	0	0
PRB4	5545	broad.mit.edu	37	12	11461589	11461589	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:11461589A>G	uc001qzf.1	-	3	362	c.328T>C	c.(328-330)TCC>CCC	p.S110P	PRB4_uc001qzt.2_Missense_Mutation_p.S110P	NM_002723	NP_002714	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	152	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.|6.		Missing (in allele M and allele S).			extracellular region				ovary(1)	1						GTACCTTGGGACTGGTTTCCT	0.602000										HNSCC(22;0.051)			5	214					0	0	0.00307968	0	0
GPRC5A	9052	broad.mit.edu	37	12	13061445	13061445	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:13061445G>A	uc001rba.2	+	2	912	c.262G>A	c.(262-264)GGA>AGA	p.G88R	GPRC5A_uc001raz.2_Missense_Mutation_p.G88R	NM_003979	NP_003970	Q8NFJ5	RAI3_HUMAN	G protein-coupled receptor, family C, group 5,	88	Helical; Name=2; (Potential).					cytoplasmic vesicle membrane|Golgi apparatus|integral to plasma membrane	G-protein coupled receptor activity				0		Prostate(47;0.141)		BRCA - Breast invasive adenocarcinoma(232;0.0708)	Tretinoin(DB00755)	CTTCATCATCGGACTGGACGG	0.552000													54	134					0	0	0.00361006	0	0
PTPRO	5800	broad.mit.edu	37	12	15661550	15661550	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:15661550A>C	uc001rcv.1	+	7	1487	c.1313A>C	c.(1312-1314)CAC>CCC	p.H438P	PTPRO_uc001rcw.1_Missense_Mutation_p.H438P|PTPRO_uc001rcu.1_Missense_Mutation_p.H438P	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	438	Fibronectin type-III 5.|Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.H438H(1)		skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				AAGCCGCAGCACGTGAGTGTC	0.502000													14	25					0	0	0.00400662	0	0
PLCZ1	89869	broad.mit.edu	37	12	18847966	18847966	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:18847966C>T	uc010sid.1	-	12	1530	c.1339G>A	c.(1339-1341)GGG>AGG	p.G447R	PLCZ1_uc001rdv.3_Missense_Mutation_p.G343R|PLCZ1_uc001rdw.3_Missense_Mutation_p.G188R|PLCZ1_uc001rdu.1_Missense_Mutation_p.G229R|PLCZ1_uc009zil.1_RNA	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	447	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					AAAAATTTCCCATTTTGCAGA	0.343000													12	44					0	0	0.00136819	0	0
CAPZA3	93661	broad.mit.edu	37	12	18891911	18891911	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:18891911C>T	uc001rdy.2	+	1	867	c.709C>T	c.(709-711)CAA>TAA	p.Q237*	PLCZ1_uc001rdv.3_5'Flank|PLCZ1_uc001rdw.3_5'Flank|PLCZ1_uc010sid.1_5'Flank	NM_033328	NP_201585	Q96KX2	CAZA3_HUMAN	capping protein alpha 3	237					actin cytoskeleton organization|actin filament capping	F-actin capping protein complex	actin binding			ovary(1)|central_nervous_system(1)	2	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)	Hepatocellular(102;0.194)				GAACAAATTTCAAGCTGCAGT	0.423000													23	48					0	0	0.00278032	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21036450	21036450	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:21036450G>A	uc001rek.2	+	12	1722	c.1596G>A	c.(1594-1596)AGG>AGA	p.R532R	SLCO1B3_uc001rel.2_Silent_p.R532R|SLCO1B3_uc010sil.1_Silent_p.R532R|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Silent_p.R357R	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	532	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					CTTGTACAAGGAAATTTTTCA	0.373000													26	53					0	0	0.00106085	0	0
ALG10B	144245	broad.mit.edu	37	12	38714839	38714839	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:38714839C>T	uc001rln.3	+	3	1385	c.1246C>T	c.(1246-1248)CGT>TGT	p.R416C	ALG10B_uc001rlo.3_Missense_Mutation_p.R386C|ALG10B_uc010skk.1_Missense_Mutation_p.R356C	NM_001013620	NP_001013642	Q5I7T1	AG10B_HUMAN	asparagine-linked glycosylation 10 homolog B	416	Extracellular (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			ovary(2)|skin(1)	3	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				GCTGGAATTTCGTTACTTCAT	0.333000													41	118					0	0	0.00361006	0	0
NELL2	4753	broad.mit.edu	37	12	44913944	44913944	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:44913944C>T	uc001rog.2	-	19	2839	c.2244G>A	c.(2242-2244)GAG>GAA	p.E748E	NELL2_uc001rof.3_Silent_p.E747E|NELL2_uc001roh.2_Silent_p.E748E|NELL2_uc009zkd.2_Silent_p.E700E|NELL2_uc010skz.1_Silent_p.E798E|NELL2_uc010sla.1_Silent_p.E771E	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	748	VWFC 4.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		AGCACTCATTCTCTGGGAGAA	0.542000													10	9					0	0	0.000442599	0	0
COL2A1	1280	broad.mit.edu	37	12	48376908	48376908	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:48376908C>T	uc001rqu.2	-	32	2243	c.2062G>A	c.(2062-2064)GAA>AAA	p.E688K	COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Missense_Mutation_p.E619K	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	688	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	GCTCCAGCTTCACCGGGAACA	0.577000													4	7					0	0	0.00024832	0	0
LASS5	91012	broad.mit.edu	37	12	50524370	50524370	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:50524370C>T	uc001rwd.3	-	10	1154	c.1137G>A	c.(1135-1137)CGG>CGA	p.R379R	LASS5_uc001rwc.2_3'UTR|LASS5_uc001rwe.3_Silent_p.R320R|LASS5_uc001rwf.3_RNA	NM_147190	NP_671723	Q8N5B7	CERS5_HUMAN	LAG1 homolog, ceramide synthase 5	379	Lumenal (Potential).				ceramide biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0						GACCATTCACCCGATTGGCAC	0.522000													38	50					0	0	0.00128727	0	0
KRT6A	3853	broad.mit.edu	37	12	52881529	52881529	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:52881529G>A	uc001sam.2	-	9	1879	c.1670C>T	c.(1669-1671)TCC>TTC	p.S557F		NM_005554	NP_005545	P02538	K2C6A_HUMAN	keratin 6A	557	Tail.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			ovary(4)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.189)		CTTCCTGCTGGAGGAGGAGGT	0.602000													22	56					0	0	0.00127121	0	0
SPRYD3	84926	broad.mit.edu	37	12	53470996	53470996	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:53470996G>A	uc001sbt.1	-	2	94	c.73C>T	c.(73-75)CTG>TTG	p.L25L	SPRYD3_uc010snw.1_5'UTR	NM_032840	NP_116229	Q8NCJ5	SPRY3_HUMAN	SPRY domain containing 3	25	B30.2/SPRY.									central_nervous_system(1)	1						CGCCAATTCAGAAACCGGTAG	0.507000													11	30					0	0	0.000978159	0	0
ATF7	11016	broad.mit.edu	37	12	53928439	53928439	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:53928439A>G	uc001sdy.2	-	5	461	c.440T>C	c.(439-441)GTT>GCT	p.V147A	ATF7_uc010sok.1_RNA|ATF7_uc001sdz.2_Missense_Mutation_p.V136A|ATF7_uc010sol.1_Missense_Mutation_p.V115A	NM_001130059	NP_001123531	P17544	ATF7_HUMAN	activating transcription factor 7 isoform 1	147	Transactivation domain.				interspecies interaction between organisms	cytoplasm|nuclear periphery|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						CTTTGGGGTAACCTCCTGGAG	0.433000													11	45					0	0	0.000978159	0	0
ITGA5	3678	broad.mit.edu	37	12	54798666	54798666	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:54798666C>T	uc001sga.2	-	13	1306	c.1238G>A	c.(1237-1239)GGG>GAG	p.G413E	ITGA5_uc010sow.1_RNA	NM_002205	NP_002196	P08648	ITA5_HUMAN	integrin alpha 5 precursor	413	Extracellular (Potential).|FG-GAP 6.				angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			ovary(2)	2						AAAGGGAGCCCCGATGGCCAC	0.582000											OREG0021554	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	9					0	0	6.4e-05	0	0
OR10A7	121364	broad.mit.edu	37	12	55614962	55614962	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:55614962G>A	uc010spf.1	+	1	154	c.154G>A	c.(154-156)GAT>AAT	p.D52N		NM_001005280	NP_001005280	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A,	52	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)	4						TACCAGTGTGGATCTCGCACT	0.393000													61	144					0	0	0.00361006	0	0
PTPRB	5787	broad.mit.edu	37	12	71029686	71029686	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:71029686G>A	uc001swc.3	-	2	260	c.216C>T	c.(214-216)TCC>TCT	p.S72S	PTPRB_uc001swa.3_Silent_p.S72S|PTPRB_uc001swd.3_Silent_p.S71S|PTPRB_uc009zrr.1_Intron|PTPRB_uc001swe.2_Silent_p.S72S	NM_001109754	NP_001103224	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	Error:Variant_position_missing_in_P23467_after_alignment					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GGGAAGAGTTGGAGATGGCCA	0.562000													10	16					0	0	0.000978159	0	0
TRHDE	29953	broad.mit.edu	37	12	72863634	72863634	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:72863634C>T	uc001sxa.2	+	4	1307	c.1277C>T	c.(1276-1278)TCA>TTA	p.S426L		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	426	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						CCCAGTGTTTCATCTATTTCT	0.393000													12	46					0	0	0.00185496	0	0
SSH1	54434	broad.mit.edu	37	12	109186493	109186494	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:109186493_109186494GG>AA	uc001tnm.2	-	14	1548_1549	c.1461_1462CC>TT	c.(1459-1464)ACCCCG>ACTTCG	p.P488S	SSH1_uc001tnl.2_Missense_Mutation_p.P176S|SSH1_uc010sxg.1_Missense_Mutation_p.P499S|SSH1_uc001tnn.3_Missense_Mutation_p.P488S	NM_018984	NP_061857	Q8WYL5	SSH1_HUMAN	slingshot 1 isoform 1	488					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4						TGGCTTTCCGGGGTGCCATCTG	0.644000													20	44					0	0	6.4e-05	0	0
HVCN1	84329	broad.mit.edu	37	12	111089247	111089247	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:111089247G>A	uc001trs.1	-	6	583	c.418C>T	c.(418-420)CAC>TAC	p.H140Y	HVCN1_uc001trq.1_Missense_Mutation_p.H140Y|HVCN1_uc001trt.1_Missense_Mutation_p.H140Y|HVCN1_uc010syd.1_Missense_Mutation_p.H120Y	NM_032369	NP_115745	Q96D96	HVCN1_HUMAN	hydrogen voltage-gated channel 1	140	Helical; Name=Segment S2; (By similarity).			H->A: Exhibits selectivity to protons but sensitivity to zinc ions is abolished; when associated with A-193.	response to pH|response to zinc ion	integral to membrane	voltage-gated proton channel activity			skin(1)	1						CTCATGTAGTGGAATACCTGA	0.478000													10	15					0	0	0.000442599	0	0
ACAD10	80724	broad.mit.edu	37	12	112182825	112182825	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:112182825C>T	uc001tsq.2	+	13	2293	c.2093C>T	c.(2092-2094)TCC>TTC	p.S698F	ACAD10_uc001tsp.2_Missense_Mutation_p.S698F|ACAD10_uc009zvx.2_Missense_Mutation_p.S729F|ACAD10_uc001tss.1_RNA	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	698							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						TGGAGCCCCTCCCCACTGATC	0.602000													13	30					0	0	0.00244969	0	0
MED13L	23389	broad.mit.edu	37	12	116434479	116434479	+	Nonsense_Mutation	SNP	G	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:116434479G>T	uc001tvw.2	-	16	2853	c.2798C>A	c.(2797-2799)TCA>TAA	p.S933*		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	933					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		GTGCACATATGAAAAGTCCTG	0.418000													10	40					0.000673444	0.00234747	0.000673444	1	0
P2RX7	5027	broad.mit.edu	37	12	121603181	121603181	+	Silent	SNP	C	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:121603181C>G	uc001tzm.2	+	6	651	c.555C>G	c.(553-555)GCC>GCG	p.A185A	P2RX7_uc001tzn.2_Silent_p.A95A|P2RX7_uc001tzo.2_RNA|P2RX7_uc001tzp.2_5'UTR|P2RX7_uc001tzq.2_Silent_p.A15A	NM_002562	NP_002553	Q99572	P2RX7_HUMAN	purinergic receptor P2X7	185						integral to membrane	ATP binding|ion channel activity|receptor activity			large_intestine(2)|lung(1)|breast(1)|skin(1)	5	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TGAACAGTGCCGAAAACTTCA	0.517000													40	228					0	0	0.00195071	0	0
KNTC1	9735	broad.mit.edu	37	12	123034322	123034322	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:123034322C>T	uc001ucv.2	+	13	1160	c.997C>T	c.(997-999)CTC>TTC	p.L333F	KNTC1_uc010taf.1_Missense_Mutation_p.L296F	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	333					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		GATGAAAAACCTCATGGTTTA	0.308000													3	8					0	0	6.4e-05	0	0
HIP1R	9026	broad.mit.edu	37	12	123335413	123335413	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:123335413C>T	uc001udj.1	+	6	529	c.470C>T	c.(469-471)ACA>ATA	p.T157I	HIP1R_uc001udg.1_Missense_Mutation_p.T145I|HIP1R_uc001udi.1_Missense_Mutation_p.T157I	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	157					receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		CTGGAGGTGACAGATGAGGTA	0.622000													17	57					0	0	0.00121646	0	0
DNAH10	196385	broad.mit.edu	37	12	124403268	124403268	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:124403268G>A	uc001uft.3	+	64	10949	c.10924G>A	c.(10924-10926)GAC>AAC	p.D3642N		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3642					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CTTGGACATCGACAGGCTGCG	0.577000													9	19					0	0	0.000673444	0	0
TMEM132B	114795	broad.mit.edu	37	12	126128723	126128723	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:126128723C>T	uc001uhe.1	+	6	1532	c.1524C>T	c.(1522-1524)TTC>TTT	p.F508F	TMEM132B_uc001uhf.1_Silent_p.F20F	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	508	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CCTCCCAGTTCGAGGTCACTG	0.527000													26	42					0	0	0.00127121	0	0
POLE	5426	broad.mit.edu	37	12	133226033	133226033	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:133226033G>A	uc001uks.1	-	31	3908	c.3864C>T	c.(3862-3864)GCC>GCT	p.A1288A	POLE_uc001ukr.1_Silent_p.A92A|POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Silent_p.A1261A	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1288					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		TCTTCCTGCGGGCGAGGCGCT	0.657000								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					6	54					0	0	0.00307968	0	0
GOLGA3	2802	broad.mit.edu	37	12	133357462	133357462	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:133357462G>A	uc001ukz.1	-	18	4063	c.3504C>T	c.(3502-3504)CGC>CGT	p.R1168R	GOLGA3_uc001ula.1_Silent_p.R1168R	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	1168	Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GCTTCATCTGGCGATCCTCCT	0.537000													15	46					0	0	0.00244969	0	0
RNF17	56163	broad.mit.edu	37	13	25433214	25433214	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr13:25433214G>A	uc001upr.2	+	26	3727	c.3686G>A	c.(3685-3687)TGG>TAG	p.W1229*	RNF17_uc010tdd.1_Nonsense_Mutation_p.W1088*|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Nonsense_Mutation_p.W1225*|RNF17_uc001ups.2_Nonsense_Mutation_p.W1168*|RNF17_uc010aac.2_Nonsense_Mutation_p.W427*|RNF17_uc010aad.2_Nonsense_Mutation_p.W281*	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1229	Tudor 3.				multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		CCTTATTTCTGGAAAAAAGGA	0.373000													10	25					0	0	0.000673444	0	0
NBEA	26960	broad.mit.edu	37	13	36242646	36242646	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr13:36242646C>T	uc001uvb.2	+	57	8946	c.8740C>T	c.(8740-8742)CAT>TAT	p.H2914Y	NBEA_uc010abi.2_Missense_Mutation_p.H1572Y|NBEA_uc010tef.1_Missense_Mutation_p.H707Y|NBEA_uc001uvd.2_Missense_Mutation_p.H492Y	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2914	WD 5.					cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GGACTTGTCCCATGACCAGAG	0.493000													19	21					0	0	0.00229938	0	0
TRPC4	7223	broad.mit.edu	37	13	38225576	38225576	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr13:38225576C>T	uc001uws.2	-	8	2140	c.1905G>A	c.(1903-1905)TGG>TGA	p.W635*	TRPC4_uc010abv.2_Nonsense_Mutation_p.W215*|TRPC4_uc001uwt.2_Nonsense_Mutation_p.W635*|TRPC4_uc010tey.1_Nonsense_Mutation_p.W635*|TRPC4_uc010abw.2_Nonsense_Mutation_p.W462*|TRPC4_uc010abx.2_Nonsense_Mutation_p.W635*|TRPC4_uc010aby.2_Intron	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	635	Binds to ITPR1, ITPR2 and ITPR3.|Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		GTGCAAATTTCCATTCTATAT	0.428000													11	27					0	0	0.000978159	0	0
DOCK9	23348	broad.mit.edu	37	13	99538816	99538816	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr13:99538816G>A	uc001vnt.2	-	19	2164	c.2109C>T	c.(2107-2109)CAC>CAT	p.H703H	DOCK9_uc001vnw.2_Silent_p.H702H|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Silent_p.H703H|DOCK9_uc010tis.1_Silent_p.H702H|DOCK9_uc010tit.1_Silent_p.H703H|DOCK9_uc010afu.1_Silent_p.H518H	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	703	DHR-1.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TTTGGTGATGGTGTAAAACTG	0.403000													8	32					0	0	0.000442599	0	0
OR4N5	390437	broad.mit.edu	37	14	20612775	20612775	+	Missense_Mutation	SNP	T	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr14:20612775T>G	uc010tla.1	+	1	881	c.881T>G	c.(880-882)GTG>GGG	p.V294G		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	294	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		AACCAGGAGGTGAAAGCTTCC	0.403000													22	36					0	0	0.00395357	0	0
OR4E2	26686	broad.mit.edu	37	14	22134212	22134212	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr14:22134212G>A	uc010tmd.1	+	1	916	c.916G>A	c.(916-918)GTT>ATT	p.V306I		NM_001001912	NP_001001912	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E,	306	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		GCAGAGACAAGTTTTTTTCAC	0.408000													5	8					0	0	0.000602214	0	0
TSSK4	283629	broad.mit.edu	37	14	24677292	24677292	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr14:24677292G>A	uc001wng.2	+	4	1095	c.927G>A	c.(925-927)GAG>GAA	p.E309E	TM9SF1_uc010tob.1_Intron|TSSK4_uc001wne.2_Silent_p.E233E|TSSK4_uc001wnf.2_Silent_p.E239E|TSSK4_uc001wnh.2_Silent_p.E319E	NM_174944	NP_777604	Q6SA08	TSSK4_HUMAN	testis-specific serine kinase 4	309					cell differentiation|multicellular organismal development|positive regulation of CREB transcription factor activity|spermatogenesis		ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity				0				GBM - Glioblastoma multiforme(265;0.018)		GGCTGCTTGAGGCCATGTGCC	0.542000													14	27					0	0	0.00244969	0	0
TRMT5	57570	broad.mit.edu	37	14	61446310	61446310	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr14:61446310C>T	uc001xff.3	-	2	397	c.306G>A	c.(304-306)AGG>AGA	p.R102R	SLC38A6_uc001xfg.1_5'Flank|SLC38A6_uc001xfh.1_5'Flank|SLC38A6_uc001xfi.2_5'Flank|SLC38A6_uc001xfj.1_5'Flank|SLC38A6_uc001xfk.2_5'Flank|SLC38A6_uc010trz.1_5'Flank	NM_020810	NP_065861	Q32P41	TRMT5_HUMAN	tRNA methyltransferase 5	102						cytoplasm	tRNA (guanine-N1-)-methyltransferase activity			central_nervous_system(2)|large_intestine(1)	3				OV - Ovarian serous cystadenocarcinoma(108;0.0873)		CTATTTCTTTCCTCACTTTAA	0.408000													36	68					0	0	0.00375469	0	0
SNAPC1	6617	broad.mit.edu	37	14	62245615	62245615	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr14:62245615C>T	uc001xft.2	+	7	916	c.812C>T	c.(811-813)TCA>TTA	p.S271L		NM_003082	NP_003073	Q16533	SNPC1_HUMAN	small nuclear RNA activating complex,	271					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.0639)|BRCA - Breast invasive adenocarcinoma(234;0.186)		AAGGCCTTTTCAGTTGTCATA	0.244000													18	42					0	0	0.00188189	0	0
LTBP2	4053	broad.mit.edu	37	14	75052711	75052711	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr14:75052711C>T	uc001xqa.2	-	3	1063	c.676G>A	c.(676-678)GAA>AAA	p.E226K		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	226					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GGGTCAAATTCCTCATCGGGA	0.682000													14	10					0	0	0.00400662	0	0
NRXN3	9369	broad.mit.edu	37	14	79432748	79432748	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr14:79432748G>A	uc001xun.2	+	9	2148	c.1657G>A	c.(1657-1659)GGG>AGG	p.G553R	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.G678R	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	926	Extracellular (Potential).|Laminin G-like 5.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GCTTGTCAAGGGGTAAGTAGA	0.418000													28	48					0	0	0.00283554	0	0
CLMN	79789	broad.mit.edu	37	14	95670789	95670789	+	Silent	SNP	G	A	A	rs143079668		TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr14:95670789G>A	uc001yef.2	-	9	1013	c.897C>T	c.(895-897)TTC>TTT	p.F299F		NM_024734	NP_079010	Q96JQ2	CLMN_HUMAN	calmin	299						integral to membrane	actin binding				0				Epithelial(152;0.193)		TATCTGAATCGAAAATATCTT	0.289000													14	21					0	0	0.00316338	0	0
Unknown	0	broad.mit.edu	37	15	20495446	20495446	+	RNA	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:20495446G>A	uc001ytf.1	+	5		c.649G>A								full-length cDNA clone CS0DI026YN18 of Placenta Cot 25-normalized of Homo sapiens (human).																		TTCTAGCCCAGGTATTCGTAT	0.383000													9	64					0	0	0.000442599	0	0
Unknown	0	broad.mit.edu	37	15	20645802	20645802	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:20645802G>A	uc001ytg.2	-	20	2983	c.2274C>T	c.(2272-2274)TCC>TCT	p.S758S	uc010tyx.1_RNA|uc001yth.3_Silent_p.S758S|uc010tyy.1_Silent_p.S758S					RecName: Full=Putative HERC2-like protein 3;																		TCCACTGCAGGGAGCTGAGGG	0.617000													6	11					0	0	0.00116845	0	0
Unknown	0	broad.mit.edu	37	15	20645838	20645838	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:20645838G>A	uc001ytg.2	-	20	2947	c.2238C>T	c.(2236-2238)ATC>ATT	p.I746I	uc010tyx.1_RNA|uc001yth.3_Silent_p.I746I|uc010tyy.1_Silent_p.I746I					RecName: Full=Putative HERC2-like protein 3;																		GCGTGAGAGCGATGCTCTGCA	0.612000													11	12					0	0	0.000978159	0	0
OR4M2	390538	broad.mit.edu	37	15	22369378	22369378	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:22369378C>T	uc010tzu.1	+	1	803	c.803C>T	c.(802-804)TCC>TTC	p.S268F	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	268	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GACTCGTTTTCCCTAGATAAA	0.423000													26	118					0	0	0.00106085	0	0
C15orf2	23742	broad.mit.edu	37	15	24921643	24921643	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:24921643G>A	uc001ywo.2	+	1	1103	c.629G>A	c.(628-630)GGA>GAA	p.G210E		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	210					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CCTCTGGAGGGAAATGTCTAC	0.612000													8	29					0	0	0.000442599	0	0
SPRED1	161742	broad.mit.edu	37	15	38643623	38643623	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:38643623C>T	uc001zka.3	+	7	1428	c.1093C>T	c.(1093-1095)CAA>TAA	p.Q365*		NM_152594	NP_689807	Q7Z699	SPRE1_HUMAN	sprouty-related protein 1 with EVH-1 domain	365	SPR.				inactivation of MAPK activity|multicellular organismal development	caveola|nucleus	stem cell factor receptor binding			ovary(2)|lung(2)|skin(1)	5		all_cancers(109;4.88e-13)|all_epithelial(112;1.83e-11)|Lung NSC(122;2.21e-09)|all_lung(180;4.64e-08)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(113;2.41e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		ATGCATATATCAAGTTAGTTG	0.428000									Legius_syndrome				38	84					0	0	0.000953801	0	0
PAK6	56924	broad.mit.edu	37	15	40557141	40557141	+	Missense_Mutation	SNP	C	T	T	rs146905959		TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:40557141C>T	uc010bbl.2	+	4	595	c.155C>T	c.(154-156)CCC>CTC	p.P52L	PAK6_uc010bbm.2_Missense_Mutation_p.P52L|PAK6_uc001zky.3_Missense_Mutation_p.P52L|PAK6_uc010bbn.2_Missense_Mutation_p.P52L|PAK6_uc001zlb.2_Missense_Mutation_p.P52L	NM_001128628	NP_001122100	Q9NQU5	PAK6_HUMAN	p21-activated kinase 6	52	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity	p.P52L(1)		lung(5)|large_intestine(1)|ovary(1)|skin(1)	8		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		CGCCCCAAGCCCGTGGTGGAC	0.617000													18	40					0	0	0.00188189	0	0
VPS18	57617	broad.mit.edu	37	15	41192378	41192378	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:41192378G>A	uc001zne.2	+	4	1701	c.1362G>A	c.(1360-1362)GAG>GAA	p.E454E		NM_020857	NP_065908	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18	454	Potential.				endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			ovary(2)|large_intestine(1)	3		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GCTACTTTGAGGAGATTGCCC	0.622000													20	58					0	0	0.000958276	0	0
EXD1	161829	broad.mit.edu	37	15	41482309	41482309	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:41482309C>T	uc001znk.2	-	9	899	c.708G>A	c.(706-708)TGG>TGA	p.W236*	EXD1_uc001znj.2_Nonsense_Mutation_p.W34*|EXD1_uc010ucv.1_Nonsense_Mutation_p.W294*	NM_152596	NP_689809	Q8NHP7	EXD1_HUMAN	exonuclease 3'-5' domain containing 1	236					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			ovary(1)	1						GTCGGATGAACCATACTTCTG	0.368000													54	86					0	0	0.00361006	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42437807	42437807	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:42437807G>A	uc001zoz.2	-	16	1809	c.1746C>T	c.(1744-1746)TTC>TTT	p.F582F	PLA2G4F_uc010bcq.2_5'UTR|PLA2G4F_uc001zoy.2_Silent_p.F214F|PLA2G4F_uc010bcr.2_Silent_p.F333F|PLA2G4F_uc001zpa.2_Silent_p.F333F|PLA2G4F_uc010bcs.2_Silent_p.F369F	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	582	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		ACCACTCCAGGAAGCTGAGGC	0.622000													35	86					0	0	0.00128727	0	0
VPS39	23339	broad.mit.edu	37	15	42458803	42458803	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:42458803G>A	uc001zpd.2	-	16	1748	c.1597C>T	c.(1597-1599)CTG>TTG	p.L533L	VPS39_uc001zpc.2_Silent_p.L522L|VPS39_uc001zpb.2_5'Flank	NM_015289	NP_056104	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39	533					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			ovary(1)|pancreas(1)|skin(1)	3		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		TGGCCTTTCAGAGGGGAGTTG	0.557000													9	41					0	0	0.000442599	0	0
GANC	2595	broad.mit.edu	37	15	42619626	42619626	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:42619626T>A	uc001zpi.2	+	13	1800	c.1486T>A	c.(1486-1488)TTC>ATC	p.F496I	GANC_uc001zpj.1_Missense_Mutation_p.F235I	NM_198141	NP_937784	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	496					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			central_nervous_system(2)	2		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		TCTTTTTGCTTTCCCTGTTTA	0.383000													46	127					0	0	0.00361006	0	0
UBR1	197131	broad.mit.edu	37	15	43363063	43363063	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:43363063C>T	uc001zqq.2	-	5	655	c.589G>A	c.(589-591)GTG>ATG	p.V197M	UBR1_uc010udk.1_Missense_Mutation_p.V197M	NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	197					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		TATTTTATCACTGAAGGAAAT	0.378000													36	83					0	0	0.00327116	0	0
SPG11	80208	broad.mit.edu	37	15	44890914	44890914	+	Silent	SNP	T	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:44890914T>C	uc001ztx.2	-	22	3838	c.3807A>G	c.(3805-3807)AGA>AGG	p.R1269R	SPG11_uc010ueh.1_Silent_p.R1269R|SPG11_uc010uei.1_Silent_p.R1269R|SPG11_uc001zty.1_5'UTR	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	1269	Cytoplasmic (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		TCATATCAACTCTGAGCTTGA	0.418000													20	58					0	0	0.00188189	0	0
C15orf33	196951	broad.mit.edu	37	15	49833925	49833925	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:49833925C>T	uc001zxl.2	-	10	1120	c.826G>A	c.(826-828)GAT>AAT	p.D276N	C15orf33_uc001zxm.2_Missense_Mutation_p.D242N	NM_152647	NP_689860	Q96M60	CO033_HUMAN	hypothetical protein LOC196951	276										ovary(1)	1		all_lung(180;0.00187)		all cancers(107;3.45e-08)|GBM - Glioblastoma multiforme(94;0.000124)		TTAAATTCATCATTAAAGAGG	0.279000													30	131					0	0	0.00327116	0	0
ATP8B4	79895	broad.mit.edu	37	15	50215620	50215620	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:50215620G>A	uc001zxu.2	-	17	1856	c.1714C>T	c.(1714-1716)CCT>TCT	p.P572S	ATP8B4_uc010ber.2_Missense_Mutation_p.P445S|ATP8B4_uc010ufd.1_Missense_Mutation_p.P382S|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	572	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TCATTGGAAGGATGAAGTTTT	0.408000													11	29					0	0	0.00136819	0	0
MAPK6	5597	broad.mit.edu	37	15	52356250	52356250	+	Nonsense_Mutation	SNP	G	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:52356250G>T	uc002abp.2	+	6	2013	c.1219G>T	c.(1219-1221)GAA>TAA	p.E407*		NM_002748	NP_002739	Q16659	MK06_HUMAN	mitogen-activated protein kinase 6	407					cell cycle		ATP binding|MAP kinase activity			lung(3)|ovary(1)	4				all cancers(107;0.0028)		TGGAGATCGGGAAAAGTATCT	0.403000													11	40					9.05144e-12	3.18177e-11	0.00185496	1	0
MAPK6	5597	broad.mit.edu	37	15	52356254	52356254	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:52356254A>G	uc002abp.2	+	6	2017	c.1223A>G	c.(1222-1224)AAG>AGG	p.K408R		NM_002748	NP_002739	Q16659	MK06_HUMAN	mitogen-activated protein kinase 6	408					cell cycle		ATP binding|MAP kinase activity			lung(3)|ovary(1)	4				all cancers(107;0.0028)		GATCGGGAAAAGTATCTGGAG	0.408000													12	40					0	0	0.00244969	0	0
MYO5A	4644	broad.mit.edu	37	15	52681452	52681452	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:52681452G>A	uc002aby.2	-	13	1895	c.1651C>T	c.(1651-1653)CAA>TAA	p.Q551*	MYO5A_uc002abx.3_Nonsense_Mutation_p.Q551*|MYO5A_uc010uge.1_Nonsense_Mutation_p.Q420*	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	551	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		GCAAAATGTTGGATGATGAAA	0.353000													9	41					0	0	0.000673444	0	0
UNC13C	440279	broad.mit.edu	37	15	54792317	54792317	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:54792317G>A	uc002ack.2	+	19	5101	c.5101G>A	c.(5101-5103)GAA>AAA	p.E1701K		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1701	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AGATGAAAACGAAGATGTGTC	0.348000													10	25					0	0	0.00244969	0	0
SMAD3	4088	broad.mit.edu	37	15	67482846	67482846	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:67482846C>T	uc002aqj.2	+	9	1548	c.1250C>T	c.(1249-1251)CCA>CTA	p.P417L	SMAD3_uc010ujr.1_Missense_Mutation_p.P312L|SMAD3_uc010ujs.1_Missense_Mutation_p.P373L|SMAD3_uc010ujt.1_Missense_Mutation_p.P222L	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	417	MH2.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		ATGGGCTCCCCAAGCATCCGC	0.547000													15	19					0	0	0.000566183	0	0
PML	5371	broad.mit.edu	37	15	74337233	74337233	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:74337233G>A	uc002awv.2	+	9	2673	c.2533G>A	c.(2533-2535)GCT>ACT	p.A845T	PML_uc002awu.2_Missense_Mutation_p.A797T|PML_uc010ule.1_Missense_Mutation_p.A406T	NM_033238	NP_150241	P29590	PML_HUMAN	promyelocytic leukemia protein isoform 1	845					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding|zinc ion binding			central_nervous_system(2)|kidney(2)|breast(1)	5						CAACCTGCAGGCTCTGGGCAC	0.652000			T	RARA|PAX5	APL|ALL								29	55					0	0	0.001512	0	0
GOLGA6A	342096	broad.mit.edu	37	15	74368313	74368313	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:74368313C>T	uc002axa.1	-	8	619	c.578G>A	c.(577-579)AGA>AAA	p.R193K		NM_001038640	NP_001033729	Q9NYA3	GOG6A_HUMAN	golgi autoantigen, golgin subfamily a, 6	193	Potential.										0						GACCGCTTCTCTGCAGCTCGA	0.562000													21	104					0	0	0.00395357	0	0
ISLR	3671	broad.mit.edu	37	15	74467238	74467238	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:74467238G>A	uc002axg.1	+	2	321	c.39G>A	c.(37-39)CTG>CTA	p.L13L	ISLR_uc002axh.1_Silent_p.L13L	NM_005545	NP_005536	O14498	ISLR_HUMAN	immunoglobulin superfamily containing	13					cell adhesion	extracellular region				large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						CGCTTCTCCTGGGCCTGGCTC	0.632000													15	45					0	0	0.000566183	0	0
SCAMP5	192683	broad.mit.edu	37	15	75310792	75310792	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:75310792G>A	uc002azk.1	+	6	591	c.429G>A	c.(427-429)ACG>ACA	p.T143T	SCAMP5_uc002azl.1_Silent_p.T143T|SCAMP5_uc002azm.1_Silent_p.T143T|SCAMP5_uc002azn.1_Silent_p.T151T|SCAMP5_uc010uly.1_Silent_p.T72T	NM_138967	NP_620417	Q8TAC9	SCAM5_HUMAN	secretory carrier membrane protein 5	143	Extracellular (Potential).				exocytosis|negative regulation of endocytosis|positive regulation of calcium ion-dependent exocytosis|positive regulation of cytokine secretion|protein transport|response to endoplasmic reticulum stress	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane|trans-Golgi network membrane	protein binding			ovary(1)	1						TCTTCGGAACGAACATTGGCT	0.592000													54	127					0	0	0.00361006	0	0
IGF1R	3480	broad.mit.edu	37	15	99459195	99459195	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:99459195C>T	uc002bul.2	+	9	1881	c.1831C>T	c.(1831-1833)CCT>TCT	p.P611S	IGF1R_uc010urq.1_Missense_Mutation_p.P611S|IGF1R_uc010bon.2_Missense_Mutation_p.P611S|IGF1R_uc010urr.1_Missense_Mutation_p.P61S	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	611	Fibronectin type-III 2.				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	CTCTCCAGTTCCTTCCATTCC	0.463000													51	135					0	0	0.00361006	0	0
LINS1	55180	broad.mit.edu	37	15	101109526	101109526	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:101109526G>A	uc002bwe.2	-	8	2482	c.2191C>T	c.(2191-2193)CTT>TTT	p.L731F	LINS1_uc002bwd.2_Missense_Mutation_p.L318F|LINS1_uc002bwf.2_Missense_Mutation_p.L731F|LINS1_uc002bwg.2_Missense_Mutation_p.L731F|LINS1_uc002bwh.2_Missense_Mutation_p.L731F	NM_001040614	NP_001035704	Q8NG48	LINES_HUMAN	lines homolog 1	731											0	Lung NSC(78;0.0018)|all_lung(78;0.00223)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00095)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			TATGGGAAAAGATTTTTCTTT	0.328000													29	79					0	0	0.00178596	0	0
WDR90	197335	broad.mit.edu	37	16	706315	706315	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:706315C>T	uc002cii.1	+	18	2034	c.1980C>T	c.(1978-1980)CCC>CCT	p.P660P	WDR90_uc002cig.1_3'UTR|WDR90_uc002cih.1_3'UTR|WDR90_uc002cij.1_Intron|WDR90_uc002cik.1_Silent_p.P187P|WDR90_uc002cil.1_5'Flank|WDR90_uc002cim.1_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	660	WD 5.									ovary(1)	1		Hepatocellular(780;0.0218)				ACGAGGGCCCCGTCAGCTCAG	0.697000													5	16					0	0	0.00116845	0	0
BAIAP3	8938	broad.mit.edu	37	16	1395287	1395287	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:1395287C>T	uc002clk.1	+	22	2083	c.2083C>T	c.(2083-2085)CCC>TCC	p.P695S	BAIAP3_uc002clj.2_Missense_Mutation_p.P677S|BAIAP3_uc010uuz.1_Missense_Mutation_p.P660S|BAIAP3_uc010uva.1_Missense_Mutation_p.P632S|BAIAP3_uc010uvc.1_Missense_Mutation_p.P624S	NM_003933	NP_003924	O94812	BAIP3_HUMAN	BAI1-associated protein 3	695	MHD1.				G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			pancreas(1)	1		Hepatocellular(780;0.0893)				CATCCACGCCCCCTTCCTGCC	0.642000													19	52					0	0	0.000958276	0	0
ABCC1	4363	broad.mit.edu	37	16	16215894	16215894	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:16215894C>T	uc010bvi.2	+	24	3628	c.3453C>T	c.(3451-3453)GTC>GTT	p.V1151V	ABCC1_uc010bvj.2_Silent_p.V1092V|ABCC1_uc010bvk.2_Silent_p.V1095V|ABCC1_uc010bvl.2_Silent_p.V1151V|ABCC1_uc010bvm.2_Silent_p.V1036V|ABCC1_uc002del.3_Silent_p.V1045V	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	1151	Cytoplasmic.|ABC transmembrane type-1 2.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GCTCCCCGGTCTATTCCCATT	0.597000													13	41					0	0	0.00136819	0	0
DNAH3	55567	broad.mit.edu	37	16	21156507	21156507	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:21156507G>A	uc010vbe.1	-	3	443	c.443C>T	c.(442-444)TCA>TTA	p.S148L	DNAH3_uc002die.2_Missense_Mutation_p.S119L	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	148	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AGTACCTGATGATGGCAGCCC	0.433000													6	9					0	0	0.00198382	0	0
PRKCB	5579	broad.mit.edu	37	16	24231416	24231416	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:24231416G>A	uc002dmd.2	+	17	2195	c.1998G>A	c.(1996-1998)GAG>GAA	p.E666E	PRKCB_uc002dme.2_3'UTR	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	666	AGC-kinase C-terminal.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	CTAACCCAGAGTTTGTCATTA	0.433000													32	50					0	0	0.00148497	0	0
CD19	930	broad.mit.edu	37	16	28950019	28950019	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:28950019G>A	uc002drs.2	+	13	1571	c.1509G>A	c.(1507-1509)ATG>ATA	p.M503I	uc010vct.1_Intron|CD19_uc010byo.1_Missense_Mutation_p.M504I	NM_001770	NP_001761	P15391	CD19_HUMAN	CD19 antigen precursor	503	Cytoplasmic (Potential).				cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			ovary(2)|central_nervous_system(1)	3						ATGAGGATATGAGAGGAATCC	0.607000													16	41					0	0	0.00121646	0	0
MVP	9961	broad.mit.edu	37	16	29857188	29857188	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:29857188G>A	uc002dui.2	+	12	2110	c.2026G>A	c.(2026-2028)GAG>AAG	p.E676K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MVP_uc002duj.2_Missense_Mutation_p.E676K|MVP_uc010vea.1_Missense_Mutation_p.E270K	NM_005115	NP_005106	Q14764	MVP_HUMAN	major vault protein	676					mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						CTCCAGGCATGAGGCTCAGAG	0.642000													11	17					0	0	0.000978159	0	0
ASPHD1	253982	broad.mit.edu	37	16	29912595	29912596	+	Missense_Mutation	DNP	AG	GA	GA			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:29912595_29912596AG>GA	uc002dut.2	+	1	449_450	c.303_304AG>GA	c.(301-306)CAAGAC>CAGAAC	p.D102N	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_5'Flank|SEZ6L2_uc002dur.3_5'Flank|SEZ6L2_uc002duq.3_5'Flank|SEZ6L2_uc002dus.3_5'Flank|SEZ6L2_uc010vec.1_5'Flank|SEZ6L2_uc010ved.1_5'Flank|ASPHD1_uc002duu.3_RNA|ASPHD1_uc010bzi.2_RNA	NM_181718	NP_859069	Q5U4P2	ASPH1_HUMAN	aspartate beta-hydroxylase domain containing 1	102	Lumenal (Potential).				peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity				0						TGGGCTCCCAAGACATGCAGGC	0.698000													18	61					0	0	6.4e-05	0	0
SALL1	6299	broad.mit.edu	37	16	51172871	51172871	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:51172871C>T	uc010vgs.1	-	2	3293	c.3262G>A	c.(3262-3264)GAG>AAG	p.E1088K	SALL1_uc010vgr.1_Missense_Mutation_p.E991K|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	1088					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CCGTTGACCTCTGTCTTGATG	0.562000													23	47					0	0	0.00278032	0	0
SALL1	6299	broad.mit.edu	37	16	51175508	51175508	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:51175508G>A	uc010vgs.1	-	2	656	c.625C>T	c.(625-627)CAG>TAG	p.Q209*	SALL1_uc010vgr.1_Nonsense_Mutation_p.Q112*|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	209					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TGGGAGAACTGGGCCACCGCC	0.607000													34	73					0	0	0.000953801	0	0
CDH16	1014	broad.mit.edu	37	16	66946411	66946411	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:66946411G>A	uc002eql.2	-	11	1428	c.1355C>T	c.(1354-1356)TCC>TTC	p.S452F	CDH16_uc010cdy.2_Missense_Mutation_p.S452F|CDH16_uc002eqm.2_Missense_Mutation_p.S355F	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	452	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GCTTACCTGGGAAGTGATGAA	0.577000													11	42					0	0	0.000673444	0	0
KCTD19	146212	broad.mit.edu	37	16	67327935	67327935	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:67327935C>T	uc002esu.2	-	12	1781	c.1730G>A	c.(1729-1731)CGA>CAA	p.R577Q	KCTD19_uc002est.2_Missense_Mutation_p.R349Q|KCTD19_uc010vjj.1_Missense_Mutation_p.R320Q	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	577						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		CTTGGCATTTCGGCATAGGGA	0.582000													59	104					0	0	0.00361006	0	0
CENPT	80152	broad.mit.edu	37	16	67865769	67865769	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:67865769G>A	uc002eun.3	-	8	960	c.411C>T	c.(409-411)CTC>CTT	p.L137L	CENPT_uc002eum.3_Silent_p.L137L|CENPT_uc010vkc.1_5'UTR|CENPT_uc010vkd.1_Intron|CENPT_uc010vke.1_Silent_p.L34L	NM_025082	NP_079358	Q96BT3	CENPT_HUMAN	centromere protein T	137					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		TGGGGGGCTCGAGCTCAGGAA	0.577000													17	22					0	0	0.00121646	0	0
CHTF8	54921	broad.mit.edu	37	16	69154546	69154547	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:69154546_69154547GG>AA	uc002ewn.1	-	4	248_249	c.147_148CC>TT	c.(145-150)ATCCCT>ATTTCT	p.P50S	CHTF8_uc002ewm.1_5'UTR|CHTF8_uc002ewo.1_Missense_Mutation_p.P31S|CHTF8_uc002ewp.1_Missense_Mutation_p.P50S	NM_001040146	NP_001035236	P0CG13	CTF8_HUMAN	chromosome transmission fidelity factor 8	50					cell cycle|DNA replication	nucleus	DNA binding				0						ATCAGCACAGGGATTCCCTTTG	0.530000													20	40					0	0	6.4e-05	0	0
TAT	6898	broad.mit.edu	37	16	71610089	71610089	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:71610089G>A	uc002fap.2	-	2	329	c.230C>T	c.(229-231)TCC>TTC	p.S77F	TAT_uc002faq.2_Missense_Mutation_p.S77F|TAT_uc002far.2_Missense_Mutation_p.S77F	NM_000353	NP_000344	P17735	ATTY_HUMAN	tyrosine aminotransferase	77					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(2)	2		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	CTCACCAATGGACAGGGAAAT	0.502000													7	16					0	0	0.00198382	0	0
ZFHX3	463	broad.mit.edu	37	16	72993437	72993437	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:72993437G>A	uc002fck.2	-	2	1281	c.608C>T	c.(607-609)TCC>TTC	p.S203F	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	203					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				TTTCCCGAAGGATGAGGCTAT	0.612000													31	97					0	0	0.00178596	0	0
FOXF1	2294	broad.mit.edu	37	16	86544358	86544358	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:86544358C>T	uc002fjl.2	+	1	226	c.183C>T	c.(181-183)ATC>ATT	p.I61I	uc002fjk.1_5'Flank	NM_001451	NP_001442	Q12946	FOXF1_HUMAN	forkhead box F1	61	Fork-head.				branching involved in open tracheal system development|cardiac left ventricle morphogenesis|embryonic ectodermal digestive tract morphogenesis|endocardial cushion development|in utero embryonic development|lung vasculature development|midgut development|pancreas development|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|ureter development|venous blood vessel development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding				0						TCATGGCCATCCAGAGTTCAC	0.642000													12	28					0	0	0.00185496	0	0
ZC3H18	124245	broad.mit.edu	37	16	88643603	88643604	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:88643603_88643604GG>AA	uc002fky.2	+	2	272_273	c.72_73GG>AA	c.(70-75)TCGGAC>TCAAAC	p.D25N	ZC3H18_uc010voy.1_Missense_Mutation_p.D25N|ZC3H18_uc010voz.1_Missense_Mutation_p.D25N|ZC3H18_uc010vpa.1_Missense_Mutation_p.D25N	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	25						nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		AGGGACTCTCGGACGATGACAT	0.599000													11	25					0	0	6.4e-05	0	0
CBFA2T3	863	broad.mit.edu	37	16	88967966	88967966	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:88967966G>A	uc002fmm.1	-	2	436	c.250C>T	c.(250-252)CCG>TCG	p.P84S	CBFA2T3_uc002fml.1_Missense_Mutation_p.P23S|CBFA2T3_uc010cif.1_Missense_Mutation_p.P23S|CBFA2T3_uc002fmn.1_Missense_Mutation_p.P84S	NM_005187	NP_005178	O75081	MTG16_HUMAN	myeloid translocation gene on chromosome 16	84	Mediates localization to the nucleus (By similarity).|Pro-rich.|Mediates interaction with PDE7A (in isoform 2).|Required for nucleolar targeting (in isoform 1).				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0275)		GCGGCAGGCGGTGGGGGCGGC	0.697000			T	RUNX1	AML								10	26					0	0	0.000978159	0	0
ATP2A3	489	broad.mit.edu	37	17	3854588	3854588	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:3854588G>A	uc002fxb.1	-	5	571	c.420C>T	c.(418-420)ATC>ATT	p.I140I	ATP2A3_uc002fwx.1_Silent_p.I140I|ATP2A3_uc002fwy.1_Silent_p.I140I|ATP2A3_uc002fwz.1_Silent_p.I140I|ATP2A3_uc002fxa.1_Silent_p.I140I|ATP2A3_uc002fxc.1_Silent_p.I140I|ATP2A3_uc002fxd.1_Silent_p.I140I	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	140	Cytoplasmic (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		CCCGGGCACGGATCCTCTGCA	0.517000													15	25					0	0	0.00074312	0	0
ZZEF1	23140	broad.mit.edu	37	17	3919720	3919720	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:3919720A>C	uc002fxe.2	-	49	8106	c.8042T>G	c.(8041-8043)CTG>CGG	p.L2681R	ZZEF1_uc002fxg.1_Missense_Mutation_p.L2R	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	2681							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CATGGTCCCCAGCATGTCCTC	0.567000													9	42					0	0	0.000442599	0	0
MINK1	50488	broad.mit.edu	37	17	4789256	4789256	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:4789256C>T	uc010vsl.1	+	8	886	c.690C>T	c.(688-690)GCC>GCT	p.A230A	MINK1_uc010vsk.1_Silent_p.A230A|MINK1_uc010vsm.1_Silent_p.A230A|MINK1_uc010vsn.1_Silent_p.A230A|MINK1_uc010vso.1_Silent_p.A175A|MINK1_uc010vsp.1_5'UTR	NM_153827	NP_722549	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1 isoform 3	230	Protein kinase.				JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)|skin(1)	6						CAGAGGGAGCCCCCCGTAAGT	0.567000													8	21					0	0	0.000442599	0	0
USP6	9098	broad.mit.edu	37	17	5048150	5048150	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:5048150G>A	uc002gau.1	+	26	4214	c.1984G>A	c.(1984-1986)GCT>ACT	p.A662T	USP6_uc002gav.1_Missense_Mutation_p.A662T|USP6_uc010ckz.1_Missense_Mutation_p.A345T	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	662					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						CTGGGAAGTAGCTGCAGAGGT	0.408000			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								17	64					0	0	0.00121646	0	0
TP53	7157	broad.mit.edu	37	17	7577082	7577082	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:7577082C>T	uc002gim.2	-	8	1050	c.856G>A	c.(856-858)GAA>AAA	p.E286K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E286K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E154K|TP53_uc010cng.1_Missense_Mutation_p.E154K|TP53_uc002gii.1_Missense_Mutation_p.E154K|TP53_uc010cnh.1_Missense_Mutation_p.E286K|TP53_uc010cni.1_Missense_Mutation_p.E286K|TP53_uc002gij.2_Missense_Mutation_p.E286K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	286	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> V (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> G (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> A (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E286K(52)|p.E286*(14)|p.E286G(14)|p.0?(7)|p.E286V(6)|p.E286Q(5)|p.?(2)|p.E286D(2)|p.E286E(2)|p.R283fs*16(2)|p.E286fs*59(2)|p.E286fs*17(2)|p.E285_N288delEEEN(1)|p.R282_E287delRRTEEE(1)|p.T284_G293del10(1)|p.G279fs*59(1)|p.E285fs*13(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.R283fs*56(1)|p.E286A(1)|p.V272_K292del21(1)|p.R283fs*59(1)|p.E285_L289delEEENL(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGATTCTCTTCCTCTGTGCGC	0.557000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			6	28					0	0	0.00307968	0	0
TP53	7157	broad.mit.edu	37	17	7578263	7578263	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:7578263G>A	uc002gim.2	-	6	780	c.586C>T	c.(586-588)CGA>TGA	p.R196*	TP53_uc002gig.1_Nonsense_Mutation_p.R196*|TP53_uc002gih.2_Nonsense_Mutation_p.R196*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R64*|TP53_uc010cng.1_Nonsense_Mutation_p.R64*|TP53_uc002gii.1_Nonsense_Mutation_p.R64*|TP53_uc010cnh.1_Nonsense_Mutation_p.R196*|TP53_uc010cni.1_Nonsense_Mutation_p.R196*|TP53_uc002gij.2_Nonsense_Mutation_p.R196*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R103*|TP53_uc002gio.2_Nonsense_Mutation_p.R64*|TP53_uc010vug.1_Nonsense_Mutation_p.R157*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	196	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R196*(125)|p.R196P(12)|p.0?(7)|p.R196R(5)|p.R196fs*51(4)|p.A189_V197delAPPQHLIRV(4)|p.R196Q(3)|p.K164_P219del(1)|p.R196L(1)|p.I195fs*50(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.R64*(1)|p.I195fs*12(1)|p.R103*(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTTCCACTCGGATAAGATGC	0.552000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	20					0	0	0.000442599	0	0
MYH3	4621	broad.mit.edu	37	17	10552993	10552993	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:10552993G>A	uc002gmq.1	-	6	620	c.543C>T	c.(541-543)TCC>TCT	p.S181S		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	181	Myosin head-like.|ATP (Potential).				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TTCCTGCCCCGGATTCTCCGC	0.478000													28	39					0	0	0.00178596	0	0
TNFAIP1	7126	broad.mit.edu	37	17	26669304	26669304	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:26669304G>A	uc002hax.1	+	6	569	c.550G>A	c.(550-552)GAG>AAG	p.E184K	TNFAIP1_uc002hay.2_Missense_Mutation_p.E184K|TNFAIP1_uc010waf.1_Missense_Mutation_p.E80K	NM_021137	NP_066960	Q13829	BACD2_HUMAN	tumor necrosis factor, alpha-induced protein 1	184					apoptosis|cell migration|DNA replication|embryo development|immune response|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|endosome|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity				0	all_lung(13;0.000294)|Lung NSC(42;0.000964)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		GAAAAACATCGAGCTGTTTGA	0.542000													11	19					0	0	0.00244969	0	0
ADAP2	55803	broad.mit.edu	37	17	29283285	29283285	+	Silent	SNP	T	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:29283285T>C	uc002hfx.2	+	10	1188	c.909T>C	c.(907-909)TTT>TTC	p.F303F	ADAP2_uc010csk.2_Silent_p.F309F|ADAP2_uc002hfy.2_Silent_p.F302F|ADAP2_uc010csl.2_RNA	NM_018404	NP_060874	Q9NPF8	ADAP2_HUMAN	centaurin-alpha 2 protein	303	PH 2.				heart development|regulation of ARF GTPase activity	mitochondrial envelope|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding, bridging|zinc ion binding	p.?(1)		ovary(1)	1						GCCAGGTTTTTCTTGGGAACA	0.592000													10	45					0	0	0.000978159	0	0
NF1	4763	broad.mit.edu	37	17	29654621	29654621	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:29654621C>T	uc002hgg.2	+	38	5706	c.5373C>T	c.(5371-5373)ATC>ATT	p.I1791I	NF1_uc002hgh.2_Silent_p.I1770I|NF1_uc002hgi.1_Silent_p.I803I|NF1_uc010cso.2_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1791					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TTGAAGAAATCTGCCTAGTAG	0.448000			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			9	70					0	0	0.000673444	0	0
HNF1B	6928	broad.mit.edu	37	17	36091655	36091655	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:36091655G>A	uc002hok.3	-	4	1197	c.976C>T	c.(976-978)CTG>TTG	p.L326L	HNF1B_uc010wdi.1_Silent_p.L300L|HNF1B_uc010cve.1_Silent_p.L134L	NM_000458	NP_000449	P35680	HNF1B_HUMAN	hepatocyte nuclear factor 1-beta isoform 1	326					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			AGAGGGTTCAGGCTGTGAGTC	0.597000									Hereditary_Prostate_Cancer				171	320					0	0	0.00361006	0	0
KRT10	3858	broad.mit.edu	37	17	38978776	38978776	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:38978776C>T	uc002hvi.2	-	1	88	c.62G>A	c.(61-63)GGA>GAA	p.G21E	KRT10_uc010cxd.2_5'Flank|TMEM99_uc002hvj.1_Intron	NM_000421	NP_000412	P13645	K1C10_HUMAN	keratin 10	21	Head.|Gly-rich.				epidermis development		protein binding|structural constituent of epidermis				0		Breast(137;0.000301)				tcctcctcctcctcctcctcc	0.413000													9	17					0	0	0.000274275	0	0
KRT9	3857	broad.mit.edu	37	17	39724582	39724582	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:39724582A>C	uc002hxe.3	-	6	1292	c.1226T>G	c.(1225-1227)CTG>CGG	p.L409R	JUP_uc010wfs.1_Intron	NM_000226	NP_000217	P35527	K1C9_HUMAN	keratin 9	409	Rod.|Coil 2.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Breast(137;0.000307)				GATCATCTGCAGCTGGCCACA	0.512000													8	62					0	0	0.000274275	0	0
SLC4A1	6521	broad.mit.edu	37	17	42336949	42336949	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:42336949C>T	uc002igf.3	-	8	759	c.610G>A	c.(610-612)GGA>AGA	p.G204R	SLC4A1_uc002igg.3_Missense_Mutation_p.G204R	NM_000342	NP_000333	P02730	B3AT_HUMAN	solute carrier family 4, anion exchanger, member	204	Cytoplasmic.				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		CCCCCATCTCCCTGTGGGAAG	0.587000													7	26					0	0	0.00307968	0	0
OSBPL7	114881	broad.mit.edu	37	17	45892672	45892672	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:45892672G>A	uc002ilx.1	-	13	1369	c.1166C>T	c.(1165-1167)TCG>TTG	p.S389L	OSBPL7_uc002ilw.1_5'UTR	NM_145798	NP_665741	Q9BZF2	OSBL7_HUMAN	oxysterol-binding protein-like protein 7	389					lipid transport		lipid binding				0						GCTGGTCTGCGATAGCTGGGG	0.607000													6	11					0	0	0.000274275	0	0
HOXB2	3212	broad.mit.edu	37	17	46621972	46621972	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:46621972T>C	uc002inm.2	-	1	422	c.302A>G	c.(301-303)AAG>AGG	p.K101R		NM_002145	NP_002136	P14652	HXB2_HUMAN	homeobox B2	101					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGCGGATTTCTTCTCTTTCAT	0.473000													4	59					0	0	0.000602214	0	0
TRIM37	4591	broad.mit.edu	37	17	57125123	57125123	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:57125123G>A	uc002iwy.3	-	16	2032	c.1588C>T	c.(1588-1590)CAG>TAG	p.Q530*	TRIM37_uc002iwz.3_Nonsense_Mutation_p.Q530*|TRIM37_uc002ixa.3_Nonsense_Mutation_p.Q408*|TRIM37_uc010woc.1_Nonsense_Mutation_p.Q496*	NM_001005207	NP_001005207	O94972	TRI37_HUMAN	tripartite motif-containing 37 protein	530						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					CCATCGAGCTGATTTACTTCA	0.393000									Mulibrey_Nanism				6	24					0	0	0.00307968	0	0
EFCAB3	146779	broad.mit.edu	37	17	60469297	60469297	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:60469297A>C	uc002izu.1	+	4	344	c.266A>C	c.(265-267)TAT>TCT	p.Y89S	EFCAB3_uc010wpc.1_Missense_Mutation_p.Y141S	NM_173503	NP_775774	Q8N7B9	EFCB3_HUMAN	EF-hand calcium binding domain 3 isoform b	89	EF-hand 2.						calcium ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)			CATGATGTCTATAATGAATTG	0.348000													44	84					0	0	0.00361006	0	0
KCNJ16	3773	broad.mit.edu	37	17	68129132	68129132	+	Silent	SNP	C	A	A	rs142625269		TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:68129132C>A	uc002jin.2	+	5	1390	c.904C>A	c.(904-906)CGA>AGA	p.R302R	KCNJ16_uc002jio.2_Silent_p.R302R|KCNJ16_uc002jip.2_Silent_p.R302R|KCNJ16_uc002jiq.2_Silent_p.R334R	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	302	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)					CTATGTTCCCCGAGAAATTCT	0.393000													5	96					0.00198382	0.00683498	0.00198382	1	0
HRH4	59340	broad.mit.edu	37	18	22056862	22056862	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr18:22056862C>T	uc002kvi.2	+	3	609	c.509C>T	c.(508-510)TCG>TTG	p.S170L	HRH4_uc010xbd.1_3'UTR|HRH4_uc010dlx.2_Missense_Mutation_p.S82L	NM_021624	NP_067637	Q9H3N8	HRH4_HUMAN	histamine H4 receptor isoform 1	170	Extracellular (Potential).					integral to membrane|plasma membrane	histamine receptor activity			ovary(2)	2	all_cancers(21;0.000545)|all_epithelial(16;6.56e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)				Clozapine(DB00363)	GGATTTTTTTCGGAATGGTAC	0.433000													33	93					0	0	0.00375469	0	0
DSC1	1823	broad.mit.edu	37	18	28710596	28710596	+	Missense_Mutation	SNP	C	T	T	rs147309022		TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr18:28710596C>T	uc002kwn.2	-	16	2828	c.2566G>A	c.(2566-2568)GGT>AGT	p.G856S	DSC1_uc002kwm.2_3'UTR|uc002kwo.1_5'Flank	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	856	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			GCCAGAGAACCTTTGCCTTCA	0.438000													23	62					0	0	0.00229938	0	0
DSG3	1830	broad.mit.edu	37	18	29046579	29046579	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr18:29046579G>A	uc002kws.2	+	11	1607	c.1498G>A	c.(1498-1500)GAT>AAT	p.D500N		NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	500	Extracellular (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CCTCGAAAAAGATGCAGTTTG	0.428000													40	100					0	0	0.00128727	0	0
C18orf34	374864	broad.mit.edu	37	18	30992029	30992029	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr18:30992029G>A	uc002kxn.2	-	2	166	c.24C>T	c.(22-24)TCC>TCT	p.S8S	C18orf34_uc010xbr.1_Silent_p.S8S|C18orf34_uc010dmf.1_Silent_p.S8S|C18orf34_uc002kxo.2_Silent_p.S8S|C18orf34_uc002kxp.2_Silent_p.S8S	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	8										ovary(1)	1						TGGAAGAAGAGGAAACTGTCT	0.209000													10	23					0	0	0.00136819	0	0
MYO5B	4645	broad.mit.edu	37	18	47402197	47402197	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr18:47402197C>T	uc002leb.2	-	26	3685	c.3397G>A	c.(3397-3399)GAA>AAA	p.E1133K	MYO5B_uc002lea.2_Missense_Mutation_p.E274K	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	1133	Potential.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		AGGCCAATTTCCTTCAAAGGA	0.498000													23	74					0	0	0.000720815	0	0
DCC	1630	broad.mit.edu	37	18	50731625	50731625	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr18:50731625C>T	uc002lfe.1	+	10	2200	c.1613C>T	c.(1612-1614)TCT>TTT	p.S538F	DCC_uc010xdr.1_Missense_Mutation_p.S386F|DCC_uc010dpf.1_Missense_Mutation_p.S193F	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	538	Extracellular (Potential).|Fibronectin type-III 2.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CAAGCTGTATCTACCTCACCT	0.423000													50	131					0	0	0.00361006	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55020146	55020146	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr18:55020146G>A	uc002lgn.2	+	1	426	c.69G>A	c.(67-69)CTG>CTA	p.L23L		NM_015879	NP_056963	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide	23	Helical; Signal-anchor for type II membrane protein; (Potential).				glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|skin(1)	2				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		TCGCCCTGCTGATTTTATCGC	0.602000													14	42					0	0	0.00244969	0	0
MALT1	10892	broad.mit.edu	37	18	56390461	56390461	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr18:56390461C>T	uc002lhm.1	+	10	1458	c.1200C>T	c.(1198-1200)CTC>CTT	p.L400L	MALT1_uc002lhn.1_Silent_p.L389L	NM_006785	NP_006776	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma	400	Caspase-like.				activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			ovary(2)|lung(1)|central_nervous_system(1)	4						AGTTTTTACTCCTTTTAGACA	0.313000			T	BIRC3	MALT								13	45					0	0	0.00185496	0	0
C19orf21	126353	broad.mit.edu	37	19	757679	757679	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:757679G>A	uc002lpo.2	+	2	816	c.733G>A	c.(733-735)GTT>ATT	p.V245I		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	245										upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGGCACGTGGTTCCCATCAA	0.662000													9	15					0	0	0.000978159	0	0
C19orf21	126353	broad.mit.edu	37	19	758513	758513	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:758513C>T	uc002lpo.2	+	2	1650	c.1567C>T	c.(1567-1569)CCC>TCC	p.P523S		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	523										upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCCAAGTCCCCCATGTCTG	0.667000													12	32					0	0	0.00136819	0	0
TLE6	79816	broad.mit.edu	37	19	2987153	2987153	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:2987153G>A	uc002lwu.2	+	6	489	c.89G>A	c.(88-90)TGG>TAG	p.W30*	TLE6_uc002lwt.2_Nonsense_Mutation_p.W153*|TLE6_uc010dtg.2_Nonsense_Mutation_p.W153*|TLE6_uc002lwv.2_5'Flank	NM_024760	NP_079036	Q9H808	TLE6_HUMAN	transducin-like enhancer of split 6 isoform 2	30					regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGGAGCCTTGGTTTTGGCAC	0.602000													36	48					0	0	0.00222228	0	0
RFX2	5990	broad.mit.edu	37	19	6040210	6040210	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:6040210G>A	uc002meb.2	-	5	572	c.303C>T	c.(301-303)GCC>GCT	p.A101A	RFX2_uc002mec.2_Silent_p.A101A|RFX2_uc010xiy.1_Silent_p.A56A	NM_000635	NP_000626	P48378	RFX2_HUMAN	regulatory factor X2 isoform a	101					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(4)|ovary(1)|skin(1)	6						TGCTGCTGGGGGCGTACATCT	0.612000													29	81					0	0	0.00178596	0	0
CLEC4M	10332	broad.mit.edu	37	19	7830105	7830105	+	Silent	SNP	C	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:7830105C>A	uc002mih.2	+	3	283	c.165C>A	c.(163-165)CTC>CTA	p.L55L	CLEC4M_uc010xjv.1_Intron|CLEC4M_uc002mhy.2_Intron|CLEC4M_uc010xjw.1_Intron|CLEC4M_uc010dvt.2_Silent_p.L55L|CLEC4M_uc010dvs.2_Silent_p.L54L|CLEC4M_uc010xjx.1_Silent_p.L27L|CLEC4M_uc002mhz.2_Silent_p.L55L|CLEC4M_uc002mic.2_Silent_p.L27L|CLEC4M_uc002mia.2_Intron	NM_001144910	NP_001138382	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M isoform	55	Helical; Signal-anchor for type II membrane protein; (Probable).				cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			pancreas(1)	1						TGCTGCAACTCCTCTCCTTCA	0.637000													23	58					3.65163e-15	1.28579e-14	0.00106085	1	0
ZNF414	84330	broad.mit.edu	37	19	8577592	8577592	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:8577592T>A	uc002mkf.2	-	3	438	c.320A>T	c.(319-321)AAG>ATG	p.K107M	ZNF414_uc002mke.3_Missense_Mutation_p.K107M|ZNF414_uc010dwf.2_Missense_Mutation_p.K96M	NM_032370	NP_115746	Q96IQ9	ZN414_HUMAN	zinc finger protein 414 isoform 2	107					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGGGATTTGCTTCCCTGCAGG	0.602000													4	0					0	0	0.000602214	0	0
MUC16	94025	broad.mit.edu	37	19	9047932	9047932	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:9047932C>T	uc002mkp.2	-	5	33903	c.33699G>A	c.(33697-33699)GAG>GAA	p.E11233E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11235	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGTCTATGGTCTCTGGTTGAC	0.483000													10	20					0	0	0.000442599	0	0
MUC16	94025	broad.mit.edu	37	19	9068414	9068414	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:9068414G>A	uc002mkp.2	-	3	19236	c.19032C>T	c.(19030-19032)TCC>TCT	p.S6344S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6346	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCATTGATGTGGAAACTATTG	0.438000													14	38					0	0	0.00185496	0	0
MUC16	94025	broad.mit.edu	37	19	9090789	9090789	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:9090789C>T	uc002mkp.2	-	1	1230	c.1026G>A	c.(1024-1026)AGG>AGA	p.R342R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	342	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGCTTCTGACCCTTTCGGCAC	0.512000													5	32					0	0	0.000602214	0	0
MUC16	94025	broad.mit.edu	37	19	9091671	9091671	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:9091671G>A	uc002mkp.2	-	1	348	c.144C>T	c.(142-144)ATC>ATT	p.I48I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	48	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGTCACCACGATTGCACCTG	0.517000													14	36					0	0	0.00244969	0	0
Unknown	0	broad.mit.edu	37	19	9801338	9801338	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:9801338C>T	uc010xkx.1	-	3	1152	c.529G>A	c.(529-531)GAA>AAA	p.E177K						RecName: Full=Zinc finger protein 562;																		TTCCCACATTCCGTATATTTG	0.378000													12	46					0	0	0.00136819	0	0
TMED1	11018	broad.mit.edu	37	19	10943869	10943869	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:10943869C>T	uc002mpy.2	-	4	602	c.486G>A	c.(484-486)CGG>CGA	p.R162R	DNM2_uc002mpx.1_3'UTR	NM_006858	NP_006849	Q13445	TMED1_HUMAN	interleukin 1 receptor-like 1 ligand precursor	162	Extracellular (Potential).				cell-cell signaling|signal transduction|transport	integral to membrane|plasma membrane	receptor binding			ovary(2)|breast(1)|central_nervous_system(1)	4						CCAGCCGGGTCCGCATGGTCT	0.627000													6	7					0	0	0.00116845	0	0
WIZ	58525	broad.mit.edu	37	19	15538022	15538022	+	Silent	SNP	T	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:15538022T>G	uc002nbc.2	-	4	1397	c.1374A>C	c.(1372-1374)CCA>CCC	p.P458P	WIZ_uc002nba.3_Silent_p.P325P|WIZ_uc002nbb.3_Silent_p.P284P	NM_021241	NP_067064	O95785	WIZ_HUMAN	widely-interspaced zinc finger motifs	1141	Pro-rich.					nucleus	zinc ion binding				0						CCGGTGGTGGTGGCAACTTCT	0.652000													9	45					0	0	0.000978159	0	0
CYP4F8	11283	broad.mit.edu	37	19	15728888	15728888	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:15728888G>A	uc002nbi.2	+	3	340	c.276G>A	c.(274-276)TTG>TTA	p.L92L	CYP4F8_uc010xoi.1_Silent_p.L92L|CYP4F8_uc010xoj.1_Intron	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	92					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						TGAGGTGGTTGGGCCCCATCA	0.597000													11	61					0	0	0.00185496	0	0
OR10H5	284433	broad.mit.edu	37	19	15905608	15905608	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:15905608C>T	uc010xos.1	+	1	750	c.750C>T	c.(748-750)GTC>GTT	p.V250V		NM_001004466	NP_001004466	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTGTGGTGGTCGTGCACTATG	0.562000													6	20					0	0	0.000274275	0	0
EPS15L1	58513	broad.mit.edu	37	19	16488050	16488050	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:16488050G>A	uc002ndz.1	-	22	2269	c.2263C>T	c.(2263-2265)CCT>TCT	p.P755S	EPS15L1_uc002ndx.2_Missense_Mutation_p.P755S|EPS15L1_uc002ndy.2_Intron|EPS15L1_uc010xpe.1_Intron|EPS15L1_uc010xpf.1_Missense_Mutation_p.P658S|EPS15L1_uc002nea.1_Intron|EPS15L1_uc010eah.1_Intron	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	755	Pro-rich.|15 X 3 AA repeats of D-P-F.|12.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						GAGGTGAAAGGGCCAGAAGGT	0.512000											OREG0025332	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	81					0	0	0.00121646	0	0
NWD1	284434	broad.mit.edu	37	19	16859961	16859961	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:16859961G>A	uc002neu.3	+	6	930	c.508G>A	c.(508-510)GAG>AAG	p.E170K	NWD1_uc002net.3_Missense_Mutation_p.E35K|NWD1_uc002nev.3_5'UTR			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	170							ATP binding			skin(3)|ovary(2)|pancreas(2)	7						CATTGAGTGGGAGATAGAGCG	0.542000													6	22					0	0	0.00198382	0	0
CPAMD8	27151	broad.mit.edu	37	19	17085952	17085952	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:17085952G>A	uc002nfb.2	-	17	2198	c.2166C>T	c.(2164-2166)TTC>TTT	p.F722F		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	675						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						AAGGCCACGGGAAGACAGAGG	0.567000													10	19					0	0	0.000673444	0	0
ZNF536	9745	broad.mit.edu	37	19	30936347	30936347	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:30936347G>A	uc002nsu.1	+	2	2016	c.1878G>A	c.(1876-1878)ATG>ATA	p.M626I	ZNF536_uc010edd.1_Missense_Mutation_p.M626I	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	626					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CTGGGAACATGAAGGAGAAGC	0.597000													23	107					0	0	0.000720815	0	0
ATP4A	495	broad.mit.edu	37	19	36046380	36046380	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:36046380G>A	uc002oal.1	-	14	2148	c.2119C>T	c.(2119-2121)CAG>TAG	p.Q707*	ATP4A_uc010eee.1_5'UTR	NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	707	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	AGCTTCTGCTGGGGGCTGGTG	0.662000													13	20					0	0	0.00136819	0	0
NPHS1	4868	broad.mit.edu	37	19	36321826	36321826	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:36321826G>A	uc002oby.2	-	28	3514	c.3514C>T	c.(3514-3516)CCT>TCT	p.P1172S		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	1172	Binds to NPHS2.|Cytoplasmic (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AAGTGCCCAGGGAAGGCCATA	0.562000													15	51					0	0	0.00244969	0	0
LGALS13	29124	broad.mit.edu	37	19	40095889	40095889	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:40095889G>A	uc002omb.2	+	3	204	c.164G>A	c.(163-165)CGA>CAA	p.R55Q		NM_013268	NP_037400	Q9UHV8	PP13_HUMAN	galectin-13	55	Galectin.				lipid catabolic process|phospholipid metabolic process		carboxylesterase activity|lysophospholipase activity|sugar binding			ovary(1)	1	all_cancers(60;1.77e-05)|all_lung(34;5.38e-08)|Lung NSC(34;6.37e-08)|Ovarian(47;0.116)		Epithelial(26;3.28e-26)|OV - Ovarian serous cystadenocarcinoma(5;7.31e-25)|all cancers(26;1.15e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			TTCCGTTTCCGAGTGCACTTT	0.498000													7	53					0	0	0.000274275	0	0
FCGBP	8857	broad.mit.edu	37	19	40408704	40408704	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:40408704G>A	uc002omp.3	-	8	4143	c.4135C>T	c.(4135-4137)CCC>TCC	p.P1379S		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	1379	VWFD 3.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TAGTTTCCGGGGACGGTGACC	0.582000													34	54					0	0	0.00327116	0	0
MAP3K10	4294	broad.mit.edu	37	19	40719021	40719021	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:40719021C>T	uc002ona.2	+	8	2051	c.1763C>T	c.(1762-1764)TCA>TTA	p.S588L	MAP3K10_uc002onb.2_5'UTR	NM_002446	NP_002437	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase	588					activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			ovary(2)|lung(2)|skin(1)|pancreas(1)	6						CAGTGGTCATCAAGTGCCCCC	0.622000													5	9					0	0	0.00116845	0	0
PRX	57716	broad.mit.edu	37	19	40902141	40902141	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:40902141G>A	uc002onr.2	-	7	2387	c.2118C>T	c.(2116-2118)CTC>CTT	p.L706L	PRX_uc002onq.2_Silent_p.L567L|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	706	44.|55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCACCTCTGGGAGGTGCACAT	0.567000													19	118					0	0	0.00278032	0	0
LTBP4	8425	broad.mit.edu	37	19	41132981	41132981	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:41132981C>T	uc002ooh.1	+	32	4288	c.4288C>T	c.(4288-4290)CCA>TCA	p.P1430S	LTBP4_uc002oog.1_Missense_Mutation_p.P1393S|LTBP4_uc002ooi.1_Missense_Mutation_p.P1363S|LTBP4_uc002ooj.1_Missense_Mutation_p.P303S|LTBP4_uc002ook.1_Missense_Mutation_p.P564S|LTBP4_uc002ool.1_Missense_Mutation_p.P442S|LTBP4_uc010xvp.1_Missense_Mutation_p.P190S	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	1430	Pro-rich.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGACTTAGGTCCACCTTACCA	0.657000													7	13					0	0	0.00198382	0	0
RAB4B	53916	broad.mit.edu	37	19	41289901	41289901	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:41289901C>T	uc002opd.1	+	5	461	c.351C>T	c.(349-351)ATC>ATT	p.I117I	RAB4B_uc002opc.1_RNA|RAB4B_uc002ope.1_Intron|EGLN2_uc010ehd.2_5'UTR|RAB4B_uc002opf.1_Silent_p.I143I	NM_016154	NP_057238	P61018	RAB4B_HUMAN	ras-related GTP-binding protein 4b	117					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	intracellular|plasma membrane	GTP binding|GTPase activity			skin(1)	1			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			TCGTGGTCATCCTCTGTGGCA	0.627000													5	28					0	0	0.00116845	0	0
ATP1A3	478	broad.mit.edu	37	19	42479928	42479928	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:42479928C>G	uc002osg.2	-	16	2270	c.2116G>C	c.(2116-2118)GGG>CGG	p.G706R	ATP1A3_uc010xwf.1_Missense_Mutation_p.G717R|ATP1A3_uc010xwg.1_Missense_Mutation_p.G676R|ATP1A3_uc010xwh.1_Missense_Mutation_p.G719R|ATP1A3_uc002osh.2_Missense_Mutation_p.G706R	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	706	Cytoplasmic (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						ACACCATCCCCGGTCACAGCC	0.463000													12	63					0	0	0.00136819	0	0
PSG8	440533	broad.mit.edu	37	19	43262160	43262160	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:43262160G>A	uc002ouo.2	-	3	801	c.703C>T	c.(703-705)CTC>TTC	p.L235F	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc010eim.2_RNA|PSG8_uc002oui.2_Missense_Mutation_p.L74F|PSG8_uc002ouh.2_Missense_Mutation_p.L235F|PSG8_uc010ein.2_Missense_Mutation_p.L113F|PSG8_uc002ouj.3_Intron|PSG8_uc002ouk.3_Missense_Mutation_p.L74F|PSG8_uc002oul.3_Missense_Mutation_p.L235F|PSG8_uc002oum.3_Intron|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Intron	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	235						extracellular region					0		Prostate(69;0.00899)				TCACGGAGGAGATTCAGGGTG	0.527000													38	183					0	0	0.00148497	0	0
ZNF223	7766	broad.mit.edu	37	19	44564992	44564992	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:44564992C>T	uc002oyf.1	+	4	486	c.233C>T	c.(232-234)TCA>TTA	p.S78L	ZNF284_uc010ejd.2_RNA	NM_013361	NP_037493	Q9UK11	ZN223_HUMAN	zinc finger protein 223	78	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0352)				GAAGGGAATTCAGGTAAGAAG	0.328000													38	67					0	0	0.00428921	0	0
PNMAL1	55228	broad.mit.edu	37	19	46973464	46973464	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:46973464C>T	uc002peq.3	-	2	1135	c.829G>A	c.(829-831)GGT>AGT	p.G277S	PNMAL1_uc002per.3_Missense_Mutation_p.G277S	NM_018215	NP_060685	Q86V59	PNML1_HUMAN	PNMA-like 1 isoform a	277											0		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		TCAGCATCACCCACCTCAGGA	0.507000													26	105					0	0	0.000720815	0	0
SYNGR4	23546	broad.mit.edu	37	19	48879000	48879000	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:48879000C>T	uc002piz.2	+	4	707	c.462C>T	c.(460-462)ATC>ATT	p.I154I		NM_012451	NP_036583	O95473	SNG4_HUMAN	synaptogyrin 4	154	MARVEL.|Helical; (Potential).					integral to membrane					0		all_epithelial(76;5.08e-07)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|Prostate(7;0.0143)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.00017)|Epithelial(262;0.0138)|GBM - Glioblastoma multiforme(486;0.0146)		TCTTCTCCATCCTTGTCTGGG	0.602000													17	47					0	0	0.00121646	0	0
RUVBL2	10856	broad.mit.edu	37	19	49507615	49507615	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:49507615G>T	uc002plr.1	+	4	218	c.205G>T	c.(205-207)GCC>TCC	p.A69S	RUVBL2_uc002plq.1_Missense_Mutation_p.A24S|RUVBL2_uc010yab.1_Missense_Mutation_p.A69S|RUVBL2_uc002pls.1_RNA|RUVBL2_uc010emn.1_Missense_Mutation_p.A24S|RUVBL2_uc010yac.1_Missense_Mutation_p.A24S	NM_006666	NP_006657	Q9Y230	RUVB2_HUMAN	RuvB-like 2	69					cellular response to UV|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|protein folding|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|membrane|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|ATP-dependent DNA helicase activity|damaged DNA binding|identical protein binding|unfolded protein binding				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000449)|OV - Ovarian serous cystadenocarcinoma(262;0.000555)|GBM - Glioblastoma multiforme(486;0.00585)|Epithelial(262;0.047)		AGGGAAGATTGCCGGTCGGGC	0.662000													20	54					8.04996e-18	2.83932e-17	0.00188189	1	0
C19orf41	126123	broad.mit.edu	37	19	50657946	50657946	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:50657946C>T	uc002prp.1	-	6	621	c.534G>A	c.(532-534)ATG>ATA	p.M178I		NM_152358	NP_689571	Q6UXV1	IZUM2_HUMAN	hypothetical protein LOC126123 precursor	178	Extracellular (Potential).					integral to membrane					0		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00364)|OV - Ovarian serous cystadenocarcinoma(262;0.0052)		ATTTGCTGTCCATCTGGTACT	0.612000													5	64					0	0	0.000602214	0	0
VSTM1	284415	broad.mit.edu	37	19	54561647	54561647	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:54561647C>T	uc002qcw.3	-	3	444	c.268G>A	c.(268-270)GAT>AAT	p.D90N	VSTM1_uc010erb.2_RNA|VSTM1_uc002qcx.3_Missense_Mutation_p.D90N	NM_198481	NP_940883	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	90	Ig-like V-type.					integral to membrane					0	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		CTCCCAGCATCCTTAGGCTTC	0.532000													21	92					0	0	0.00152264	0	0
LILRA5	353514	broad.mit.edu	37	19	54822811	54822811	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:54822811G>A	uc002qfe.2	-	5	705	c.585C>T	c.(583-585)TTC>TTT	p.F195F	LILRA5_uc002qff.2_Silent_p.F183F|LILRA5_uc010yev.1_Silent_p.F195F|LILRA5_uc010yew.1_Silent_p.F183F|LILRA5_uc002qfh.1_Silent_p.F183F|LILRA5_uc002qfg.1_Silent_p.F195F	NM_021250	NP_067073	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor subfamily	195	Extracellular (Potential).|Ig-like C2-type 2.				innate immune response	extracellular region|integral to membrane	receptor activity			upper_aerodigestive_tract(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ACAGGGCCTGGAACTGCCCAC	0.592000													8	33					0	0	0.000274275	0	0
NLRP4	147945	broad.mit.edu	37	19	56369333	56369333	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:56369333G>A	uc002qmd.3	+	3	996	c.574G>A	c.(574-576)GAA>AAA	p.E192K	NLRP4_uc002qmf.2_Missense_Mutation_p.E117K|NLRP4_uc010etf.2_Missense_Mutation_p.E23K	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	192	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CTGCTGCAGAGAACTGAGGGA	0.507000													34	80					0	0	0.00327116	0	0
NLRP8	126205	broad.mit.edu	37	19	56466752	56466752	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:56466752C>T	uc002qmh.2	+	3	1399	c.1328C>T	c.(1327-1329)TCC>TTC	p.S443F	NLRP8_uc010etg.2_Missense_Mutation_p.S443F	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	443	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GAGAACTTTTCCAGAAAGATC	0.473000													13	83					0	0	0.00185496	0	0
PEG3	5178	broad.mit.edu	37	19	57335917	57335917	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:57335917C>T	uc002qnu.2	-	1	458	c.107G>A	c.(106-108)GGA>GAA	p.G36E	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.G36E|PEG3_uc002qnv.2_Missense_Mutation_p.G36E|PEG3_uc002qnw.2_Intron|PEG3_uc002qnx.2_Intron|PEG3_uc010etr.2_Missense_Mutation_p.G36E	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	36					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TGGACCTTCTCCTATGATGAC	0.478000													23	50					0	0	0.00188189	0	0
APOB	338	broad.mit.edu	37	2	21225135	21225135	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:21225135C>T	uc002red.2	-	29	13287	c.13159G>A	c.(13159-13161)GAA>AAA	p.E4387K		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4387					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCAAAATATTCTTCACGAAGG	0.358000													206	507					0	0	0.00361006	0	0
LTBP1	4052	broad.mit.edu	37	2	33500129	33500129	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:33500129G>A	uc002ros.2	+	17	2844	c.2844G>A	c.(2842-2844)ATG>ATA	p.M948I	LTBP1_uc002rot.2_Missense_Mutation_p.M622I|LTBP1_uc002rou.2_Missense_Mutation_p.M621I|LTBP1_uc002rov.2_Missense_Mutation_p.M568I|LTBP1_uc010ymz.1_Missense_Mutation_p.M621I|LTBP1_uc010yna.1_Missense_Mutation_p.M568I	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	947	EGF-like 5; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CAGGATTTATGGCCAGTGAGG	0.463000													19	50					0	0	0.00229938	0	0
LTBP1	4052	broad.mit.edu	37	2	33525539	33525539	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:33525539G>A	uc002ros.2	+	21	3260	c.3260G>A	c.(3259-3261)GGG>GAG	p.G1087E	LTBP1_uc002rot.2_Missense_Mutation_p.G761E|LTBP1_uc002rou.2_Missense_Mutation_p.G760E|LTBP1_uc002rov.2_Missense_Mutation_p.G707E|LTBP1_uc010ymz.1_Missense_Mutation_p.G760E|LTBP1_uc010yna.1_Missense_Mutation_p.G707E|LTBP1_uc010ynb.1_Missense_Mutation_p.G26E	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1086	EGF-like 9; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TGTCAGCAAGGGAATCTATGT	0.488000													19	44					0	0	0.00278032	0	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48808712	48808712	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:48808712G>A	uc010yol.1	+	1	987	c.940G>A	c.(940-942)GGA>AGA	p.G314R	STON1_uc002rwo.3_Missense_Mutation_p.G314R|STON1_uc010fbm.2_Missense_Mutation_p.G314R|STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.G314R|STON1_uc002rwr.2_RNA|STON1_uc002rwq.2_Missense_Mutation_p.G314R	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	314					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TTATGAACAGGGATTAGAAAA	0.393000													36	79					0	0	0.00428921	0	0
BCL11A	53335	broad.mit.edu	37	2	60688028	60688028	+	Silent	SNP	G	A	A	rs115953983	by1000genomes	TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:60688028G>A	uc002sae.1	-	4	2247	c.2019C>T	c.(2017-2019)TTC>TTT	p.F673F	BCL11A_uc002sab.2_Silent_p.F673F|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Silent_p.F342F|BCL11A_uc010ypj.1_Silent_p.F639F|BCL11A_uc002sad.1_Silent_p.F521F|BCL11A_uc002saf.1_Silent_p.F639F	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	673					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			CGAAGCTAAGGAAGGGATCTT	0.642000			T	IGH@	B-CLL								145	326					0	0	0.00361006	0	0
GFPT1	2673	broad.mit.edu	37	2	69556548	69556550	+	Nonsense_Mutation	TNP	TAA	ATT	ATT			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:69556548_69556550TAA>ATT	uc002sfh.2	-	16	1729_1731	c.1550_1552TTA>AAT	c.(1549-1554)ATTAAG>AAATAG	p.517_518IK>K*		NM_002056	NP_002047	Q06210	GFPT1_HUMAN	glucosamine-fructose-6-phosphate	535_536					dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			skin(1)	1						AGTACTTCCTTAATCAAATCTAA	0.325000													8	15					0	0	6.4e-05	0	0
SNRNP200	23020	broad.mit.edu	37	2	96968966	96968966	+	Silent	SNP	G	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:96968966G>T	uc002svu.2	-	3	398	c.312C>A	c.(310-312)CCC>CCA	p.P104P		NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	104						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						CTTTAGTTTTGGGCTTGTAGA	0.448000													10	337					6.40141e-05	0.000223888	0.000978159	1	0
KIAA1310	55683	broad.mit.edu	37	2	97270077	97270077	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:97270077G>A	uc002swn.3	-	17	2205	c.2059C>T	c.(2059-2061)CCT>TCT	p.P687S	KIAA1310_uc002swh.3_Missense_Mutation_p.P573S|KIAA1310_uc002swi.3_Missense_Mutation_p.P614S|KIAA1310_uc002swj.3_RNA|KIAA1310_uc002swk.3_Missense_Mutation_p.P600S|KIAA1310_uc010fhz.2_Missense_Mutation_p.P507S|KIAA1310_uc002swl.3_Missense_Mutation_p.P586S|KIAA1310_uc002swm.3_RNA|KIAA1310_uc010yur.1_Missense_Mutation_p.P481S|KIAA1310_uc002swo.2_Missense_Mutation_p.P35S	NM_001115016	NP_001108488	Q9P2N6	K1310_HUMAN	hypothetical protein LOC55683 isoform a	713	Ser-rich.										0						ACCACTGAAGGGACTGGGCTG	0.582000													5	41					0	0	0.00116845	0	0
IL1F10	84639	broad.mit.edu	37	2	113832364	113832364	+	Silent	SNP	C	T	T	rs34320972	byFrequency	TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:113832364C>T	uc002tiu.2	+	4	258	c.183C>T	c.(181-183)ATC>ATT	p.I61I	IL1F10_uc002tiv.2_Silent_p.I61I|IL1F10_uc002tiw.2_Silent_p.I53I	NM_173161	NP_775184	Q8WWZ1	IL1FA_HUMAN	interleukin 1 family, member 10	61						extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			ovary(1)	1						TCCTGGGGATCCAGGGAGGGA	0.582000													25	46					0	0	0.000878237	0	0
SLC35F5	80255	broad.mit.edu	37	2	114486999	114486999	+	Silent	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:114486999A>G	uc002tku.1	-	11	1493	c.1069T>C	c.(1069-1071)TTG>CTG	p.L357L	SLC35F5_uc002tkt.2_RNA	NM_025181	NP_079457	Q8WV83	S35F5_HUMAN	solute carrier family 35, member F5	357					transport	integral to membrane					0						GGAATATCCAACTTGTCTTCT	0.353000													6	37					0	0	0.00116845	0	0
TMEM37	140738	broad.mit.edu	37	2	120194514	120194514	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:120194514C>T	uc002tly.2	+	2	105	c.71C>T	c.(70-72)TCC>TTC	p.S24F		NM_183240	NP_899063	Q8WXS4	CCGL_HUMAN	transmembrane protein 37	24						integral to membrane	calcium channel activity|voltage-gated ion channel activity			breast(1)	1						TTCTTTGAATCCTTCATCCGG	0.627000													28	47					0	0	0.00106085	0	0
POTEF	728378	broad.mit.edu	37	2	130869581	130869581	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:130869581C>T	uc010fmh.2	-	6	1304	c.904G>A	c.(904-906)GAT>AAT	p.D302N		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	302						cell cortex	ATP binding			skin(3)|ovary(2)	5						CCATATCTATCCAGTGCATTT	0.323000													25	33					0	0	0.00278032	0	0
FAM123C	205147	broad.mit.edu	37	2	131520521	131520521	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:131520521G>A	uc002trw.2	+	2	1066	c.876G>A	c.(874-876)GTG>GTA	p.V292V	FAM123C_uc010fmv.2_Silent_p.V292V|FAM123C_uc010fms.1_Silent_p.V292V|FAM123C_uc010fmt.1_Silent_p.V292V|FAM123C_uc010fmu.1_Silent_p.V292V	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	292										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		AGGGCAGTGTGGAGCAGCTGG	0.652000													9	45					0	0	0.000442599	0	0
POTEE	445582	broad.mit.edu	37	2	131976431	131976431	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:131976431C>T	uc002tsn.2	+	1	508	c.456C>T	c.(454-456)GTC>GTT	p.V152V	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_5'UTR|POTEE_uc002tsl.2_5'UTR	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	152							ATP binding				0						GGGGTAAAGTCCCCAGAAAGG	0.572000													22	89					0	0	0.00178596	0	0
UBXN4	23190	broad.mit.edu	37	2	136505928	136505928	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:136505928C>T	uc002tur.2	+	2	485	c.174C>T	c.(172-174)ATC>ATT	p.I58I		NM_014607	NP_055422	Q92575	UBXN4_HUMAN	UBX domain containing 2	58	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			skin(2)	2						CTATTAAAATCGATACCAAAA	0.289000													7	34					0	0	0.00198382	0	0
THSD7B	80731	broad.mit.edu	37	2	138425350	138425350	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:138425350G>A	uc002tva.1	+	26	4571	c.4571G>A	c.(4570-4572)CGA>CAA	p.R1524Q		NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		ACAGATGGCCGAGTAAAAATT	0.378000													5	9					0	0	0.000602214	0	0
KIF5C	3800	broad.mit.edu	37	2	149806890	149806890	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:149806890G>A	uc010zbu.1	+	10	1250	c.882G>A	c.(880-882)GGG>GGA	p.G294G	KIF5C_uc002tws.1_RNA	NM_004522	NP_004513	O60282	KIF5C_HUMAN	kinesin family member 5C	294	Kinesin-motor.|Microtubule-binding.				microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.108)		CTTTGGGTGGGAACTGCAGAA	0.473000													17	30					0	0	0.00074312	0	0
ARL5A	26225	broad.mit.edu	37	2	152684689	152684689	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:152684689A>G	uc002txx.1	-	1	321	c.2T>C	c.(1-3)ATG>ACG	p.M1T	ARL5A_uc010zcc.1_Intron|ARL5A_uc002txv.1_Intron|ARL5A_uc002txw.1_Intron	NM_012097	NP_036229	Q9Y689	ARL5A_HUMAN	ADP-ribosylation factor-like 5A isoform 1	1					small GTPase mediated signal transduction	intracellular	GTP binding				0				BRCA - Breast invasive adenocarcinoma(221;0.153)		GAGAATTCCCATTCTCGGGCA	0.677000													5	28					0	0	0.000602214	0	0
CCDC148	130940	broad.mit.edu	37	2	159077138	159077138	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:159077138T>A	uc002tzq.2	-	11	1602	c.1339A>T	c.(1339-1341)ATC>TTC	p.I447F	CCDC148_uc002tzr.2_Missense_Mutation_p.I295F|CCDC148_uc010foh.2_Missense_Mutation_p.I160F	NM_138803	NP_620158	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	447										ovary(2)	2						TGTTCAGCGATTAATTTCTTC	0.328000													8	23					0	0	0.000673444	0	0
DAPL1	92196	broad.mit.edu	37	2	159663565	159663565	+	Splice_Site	SNP	A	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:159663565A>C	uc002uaf.2	+	3	203	c.147_splice	c.e3-2	p.S49_splice		NM_001017920	NP_001017920	A0PJW8	DAPL1_HUMAN	death associated protein-like 1						apoptosis|cell differentiation						0						TCATCTTCACAGTGCCATTGC	0.438000													7	18					0	0	0.00198382	0	0
BAZ2B	29994	broad.mit.edu	37	2	160206398	160206398	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:160206398G>A	uc002uao.2	-	28	5036	c.4684C>T	c.(4684-4686)CTT>TTT	p.L1562F	BAZ2B_uc002uap.2_Missense_Mutation_p.L1526F	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1562					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						CGTGGCAAAAGACTAAACCAT	0.448000													19	87					0	0	0.000958276	0	0
SLC4A10	57282	broad.mit.edu	37	2	162660961	162660961	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:162660961C>T	uc002ubx.3	+	3	317	c.133C>T	c.(133-135)CAT>TAT	p.H45Y	SLC4A10_uc010fpa.1_Missense_Mutation_p.H57Y|SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Missense_Mutation_p.H45Y|SLC4A10_uc010zcs.1_Missense_Mutation_p.H56Y	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	45	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						TTATGAAGGTCATCGAACACT	0.388000													9	23					0	0	0.000978159	0	0
XIRP2	129446	broad.mit.edu	37	2	168097208	168097208	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:168097208A>G	uc002udx.2	+	6	1022	c.1004A>G	c.(1003-1005)AAC>AGC	p.N335S	XIRP2_uc010fpn.2_Missense_Mutation_p.N368S|XIRP2_uc010fpo.2_Missense_Mutation_p.N335S|XIRP2_uc010fpp.2_Missense_Mutation_p.N335S|XIRP2_uc002udy.2_Missense_Mutation_p.N160S|XIRP2_uc010fpq.2_Missense_Mutation_p.N113S|XIRP2_uc010fpr.2_Missense_Mutation_p.N113S	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	160					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GAGGAAGTAAACCAAGCATCT	0.308000													25	67					0	0	0.00106085	0	0
TTN	7273	broad.mit.edu	37	2	179489390	179489390	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:179489390C>T	uc010zfg.1	-	191	37137	c.36913G>A	c.(36913-36915)GAG>AAG	p.E12305K	TTN_uc010zfh.1_Missense_Mutation_p.E6000K|TTN_uc010zfi.1_Missense_Mutation_p.E5933K|TTN_uc010zfj.1_Missense_Mutation_p.E5808K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13232							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTTCACACTCCAGCACTGCA	0.453000													31	58					0	0	0.001512	0	0
TTN	7273	broad.mit.edu	37	2	179583666	179583666	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:179583666C>T	uc010zfg.1	-	81	20753	c.20529G>A	c.(20527-20529)GTG>GTA	p.V6843V	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.V3504V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7770							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAAAACTTCCACAGAATCAG	0.473000													4	14					0	0	0.00024832	0	0
TTN	7273	broad.mit.edu	37	2	179584546	179584546	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:179584546G>A	uc010zfg.1	-	79	20165	c.19941C>T	c.(19939-19941)ATC>ATT	p.I6647I	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.I3308I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7574							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTTCTCTATGATTCTTGCTG	0.393000													9	24					0	0	0.000274275	0	0
TTN	7273	broad.mit.edu	37	2	179615354	179615354	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:179615354C>T	uc002unb.2	-	46	11997	c.11773G>A	c.(11773-11775)GAA>AAA	p.E3925K	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.E3925D(1)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGTTTTCTTCCTTCTGTTCG	0.338000													16	31					0	0	0.00316338	0	0
ITGA4	3676	broad.mit.edu	37	2	182343501	182343501	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:182343501G>A	uc002unu.2	+	5	1337	c.574G>A	c.(574-576)GGA>AGA	p.G192R	ITGA4_uc010zfl.1_Missense_Mutation_p.G192R	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	192	FG-GAP 3.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	GAAAAAATTTGGAGAAAATTT	0.234000													6	13					0	0	0.00116845	0	0
COL5A2	1290	broad.mit.edu	37	2	189932972	189932972	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:189932972G>A	uc002uqk.2	-	20	1557	c.1282C>T	c.(1282-1284)CCT>TCT	p.P428S	COL5A2_uc010frx.2_Intron	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	428					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			TTGGCACCAGGAGTACCATCA	0.408000													44	95					0	0	0.00361006	0	0
NAB1	4664	broad.mit.edu	37	2	191524549	191524549	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:191524549A>G	uc002usb.2	+	4	1219	c.647A>G	c.(646-648)AAT>AGT	p.N216S	NAB1_uc010fsc.2_Missense_Mutation_p.N216S|NAB1_uc010fsd.2_Missense_Mutation_p.N216S|NAB1_uc002usc.2_Missense_Mutation_p.N216S|NAB1_uc010zgh.1_Missense_Mutation_p.N216S	NM_005966	NP_005957	Q13506	NAB1_HUMAN	NGFI-A binding protein 1	216					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0405)|all cancers(119;0.109)			AGTGACTTGAATGAAGTGAAA	0.493000													8	33					0	0	0.000442599	0	0
DNAH7	56171	broad.mit.edu	37	2	196726449	196726449	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:196726449C>T	uc002utj.3	-	42	7829	c.7728G>A	c.(7726-7728)AAG>AAA	p.K2576K		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2576	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ACCTTCTTTTCTTTTCTAACA	0.284000													10	35					0	0	0.000673444	0	0
DNAH7	56171	broad.mit.edu	37	2	196741347	196741347	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:196741347G>A	uc002utj.3	-	37	6139	c.6038C>T	c.(6037-6039)GCT>GTT	p.A2013V		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2013	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CTGAGTTTGAGCTGCTGTAGT	0.323000													19	44					0	0	0.00152264	0	0
TRAK2	66008	broad.mit.edu	37	2	202251159	202251159	+	Missense_Mutation	SNP	C	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:202251159C>A	uc002uyb.3	-	14	2191	c.1745G>T	c.(1744-1746)GGA>GTA	p.G582V		NM_015049	NP_055864	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	582				Missing (in Ref. 2).		early endosome|plasma membrane	GABA receptor binding				0						AAGGATGGTTCCCAAGTTTGG	0.443000													45	108					8.48111e-28	3.01181e-27	0.00361006	1	0
IKZF2	22807	broad.mit.edu	37	2	213872225	213872225	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:213872225G>A	uc002vem.2	-	8	1609	c.1440C>T	c.(1438-1440)TTC>TTT	p.F480F	IKZF2_uc010fuu.2_Silent_p.F335F|IKZF2_uc002vej.2_Silent_p.F427F|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Silent_p.F406F|IKZF2_uc002vel.2_Silent_p.F401F|IKZF2_uc010fuw.2_Silent_p.F254F|IKZF2_uc010fux.2_Silent_p.F254F|IKZF2_uc010fuy.2_Silent_p.F408F|IKZF2_uc002ven.2_Silent_p.F454F|IKZF2_uc002vei.2_Silent_p.F258F	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	480	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		CATGGTCTAGGAAAAGGACTC	0.512000													37	71					0	0	0.00148497	0	0
TNS1	7145	broad.mit.edu	37	2	218669215	218669216	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:218669215_218669216GG>AA	uc002vgt.2	-	33	5572_5573	c.5174_5175CC>TT	c.(5173-5175)TCC>TTT	p.S1725F	TNS1_uc002vgr.2_Missense_Mutation_p.S1711F|TNS1_uc002vgs.2_Missense_Mutation_p.S1704F|TNS1_uc002vgq.2_Missense_Mutation_p.S225F	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	1725						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GCATGACCTTGGAGACGAAGTT	0.624000													28	84					0	0	6.4e-05	0	0
VIL1	7429	broad.mit.edu	37	2	219301212	219301212	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:219301212G>A	uc002via.2	+	16	1899	c.1834G>A	c.(1834-1836)GAA>AAA	p.E612K	VIL1_uc010zke.1_Missense_Mutation_p.E301K|VIL1_uc002vib.2_Missense_Mutation_p.E612K	NM_007127	NP_009058	P09327	VILI_HUMAN	villin 1	612	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CAGACTACAGGAAGAAAACCT	0.512000													62	143					0	0	0.00361006	0	0
TUBA4A	7277	broad.mit.edu	37	2	220115512	220115512	+	Silent	SNP	T	C	C	rs141922502	byFrequency	TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:220115512T>C	uc002vkt.1	-	4	967	c.909A>G	c.(907-909)GTA>GTG	p.V303V	TUBA4A_uc010zkz.1_Silent_p.V288V|TUBA4B_uc002vku.2_5'Flank|TUBA4B_uc002vkv.1_5'Flank	NM_006000	NP_005991	P68366	TBA4A_HUMAN	tubulin, alpha 4a	303					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|platelet activation|platelet degranulation|protein polymerization	cytosol|extracellular region|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)	3		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000191)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GATCACACTTTACCATCTGGT	0.567000													28	59					0	0	0.00178596	0	0
CCDC140	151278	broad.mit.edu	37	2	223169005	223169005	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:223169005C>T	uc002vnb.1	+	2	768	c.384C>T	c.(382-384)CTC>CTT	p.L128L		NM_153038	NP_694583	Q96MF4	CC140_HUMAN	coiled-coil domain containing 140	128											0		Renal(207;0.0376)		Epithelial(121;4.03e-10)|all cancers(144;1.8e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CACGTACTCTCCCGACCCCTC	0.458000													11	28					0	0	0.00244969	0	0
SLC19A3	80704	broad.mit.edu	37	2	228563556	228563556	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:228563556A>G	uc002vpi.2	-	3	964	c.875T>C	c.(874-876)TTT>TCT	p.F292S	SLC19A3_uc002vpj.2_RNA|SLC19A3_uc010zlv.1_Missense_Mutation_p.F288S	NM_025243	NP_079519	Q9BZV2	S19A3_HUMAN	solute carrier family 19, member 3	292	Helical; (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	AACCTGGTTAAAACCTGCTGT	0.453000													23	64					0	0	0.00188189	0	0
NMUR1	10316	broad.mit.edu	37	2	232390033	232390033	+	Silent	SNP	G	A	A	rs149953749		TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:232390033G>A	uc002vry.3	-	3	1112	c.1002C>T	c.(1000-1002)TTC>TTT	p.F334F		NM_006056	NP_006047	Q9HB89	NMUR1_HUMAN	neuromedin U receptor 1	334	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|calcium ion transport|calcium-mediated signaling|chloride transport|smooth muscle contraction	integral to plasma membrane|membrane fraction	neuromedin U receptor activity			lung(3)|central_nervous_system(1)|pancreas(1)	5		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;8.37e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		GCACGTGCTGGAAGGCCAGGT	0.632000													24	46					0	0	0.00395357	0	0
TMC2	117532	broad.mit.edu	37	20	2591073	2591073	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:2591073C>T	uc002wgf.1	+	12	1437	c.1422C>T	c.(1420-1422)ATC>ATT	p.I474I	TMC2_uc002wgg.1_Silent_p.I458I|TMC2_uc010zpw.1_Silent_p.I306I|TMC2_uc010zpx.1_Silent_p.I305I	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	474	Extracellular (Potential).					integral to membrane				ovary(3)	3						AGGTAGAGATCGTGATGTCCC	0.512000													37	126					0	0	0.0025221	0	0
PTPRA	5786	broad.mit.edu	37	20	2969051	2969051	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:2969051G>A	uc010zqd.1	+	8	1019	c.702G>A	c.(700-702)GTG>GTA	p.V234V	PTPRA_uc002whj.2_Silent_p.V223V|PTPRA_uc010zqc.1_Silent_p.V108V|PTPRA_uc002whk.2_Silent_p.V214V|PTPRA_uc002whl.2_Silent_p.V214V|PTPRA_uc002whm.2_5'UTR|PTPRA_uc002whn.2_Silent_p.V214V|PTPRA_uc002who.2_5'UTR	NM_002836	NP_002827	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	223	Cytoplasmic (Potential).				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1						CCCTGCCCGTGGACAAGCTGG	0.527000													25	44					0	0	0.00395357	0	0
PROKR2	128674	broad.mit.edu	37	20	5282886	5282886	+	Nonsense_Mutation	SNP	C	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:5282886C>A	uc010zqw.1	-	2	955	c.955G>T	c.(955-957)GAG>TAG	p.E319*	PROKR2_uc010zqx.1_Nonsense_Mutation_p.E319*|PROKR2_uc010zqy.1_Nonsense_Mutation_p.E319*	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	319	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GCGATGCACTCGACCACGTAG	0.517000										HNSCC(71;0.22)			5	113					0.00116845	0.00405932	0.00116845	1	0
PLCB1	23236	broad.mit.edu	37	20	8717789	8717790	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:8717789_8717790GG>AA	uc002wnb.2	+	20	2161_2162	c.2158_2159GG>AA	c.(2158-2160)GGA>AAA	p.G720K	PLCB1_uc010zrb.1_Missense_Mutation_p.G619K|PLCB1_uc002wna.2_Missense_Mutation_p.G720K|PLCB1_uc002wnc.1_Missense_Mutation_p.G619K|PLCB1_uc002wnd.1_Missense_Mutation_p.G297K	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	720	C2.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						AACATCCCAAGGAAATGCTGTG	0.386000													20	56					0	0	6.4e-05	0	0
PLCB1	23236	broad.mit.edu	37	20	8717814	8717814	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:8717814A>G	uc002wnb.2	+	20	2186	c.2183A>G	c.(2182-2184)GAA>GGA	p.E728G	PLCB1_uc010zrb.1_Missense_Mutation_p.E627G|PLCB1_uc002wna.2_Missense_Mutation_p.E728G|PLCB1_uc002wnc.1_Missense_Mutation_p.E627G|PLCB1_uc002wnd.1_Missense_Mutation_p.E305G	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	728	C2.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CCTGTCTGGGAAGAAGAACCT	0.378000													16	55					0	0	0.000958276	0	0
PLCB4	5332	broad.mit.edu	37	20	9317777	9317777	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:9317777C>T	uc002wnf.2	+	4	225	c.89C>T	c.(88-90)TCC>TTC	p.S30F	PLCB4_uc010gbw.1_Missense_Mutation_p.S30F|PLCB4_uc010gbx.2_Missense_Mutation_p.S30F|PLCB4_uc002wne.2_Missense_Mutation_p.S30F	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	30					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						TGACAGGAATCCTTTGTGTTT	0.373000													20	64					0	0	0.00278032	0	0
PLCB4	5332	broad.mit.edu	37	20	9402023	9402023	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:9402023C>T	uc002wnf.2	+	25	2334	c.2198C>T	c.(2197-2199)ACC>ATC	p.T733I	PLCB4_uc010gbw.1_Missense_Mutation_p.T733I|PLCB4_uc010gbx.2_Missense_Mutation_p.T745I|PLCB4_uc002wne.2_Missense_Mutation_p.T733I|PLCB4_uc002wnh.2_Missense_Mutation_p.T580I	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	733	C2.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						CCCACTGACACCATACGTAAG	0.413000													23	47					0	0	0.00188189	0	0
ANKRD5	63926	broad.mit.edu	37	20	10030496	10030496	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:10030496G>T	uc002wno.2	+	7	1672	c.1279G>T	c.(1279-1281)GGG>TGG	p.G427W	uc002wnn.1_Intron|ANKRD5_uc002wnp.2_Missense_Mutation_p.G427W|ANKRD5_uc010gbz.2_Missense_Mutation_p.G238W	NM_022096	NP_071379	Q9NU02	ANKR5_HUMAN	ankyrin repeat domain protein 5	427							calcium ion binding			ovary(1)|breast(1)	2						AGGAAAGAAAGGGAAATTTGT	0.418000													21	53					7.41877e-09	2.60345e-08	0.00188189	1	0
PTPRT	11122	broad.mit.edu	37	20	41514563	41514563	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:41514563G>A	uc002xkg.2	-	2	282	c.98C>T	c.(97-99)TCC>TTC	p.S33F	PTPRT_uc010ggj.2_Missense_Mutation_p.S33F	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	33	Extracellular (Potential).|MAM.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CTCATCAAAGGAACAGCCACC	0.478000													27	47					0	0	0.00127121	0	0
WFDC8	90199	broad.mit.edu	37	20	44181906	44181906	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:44181906C>T	uc002xow.2	-	5	534	c.455G>A	c.(454-456)GGA>GAA	p.G152E	WFDC8_uc002xox.2_Missense_Mutation_p.G152E	NM_181510	NP_852611	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8 precursor	152	WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				TGGGCATTGTCCATCCTTAAC	0.468000													9	31					0	0	0.000673444	0	0
ACOT8	10005	broad.mit.edu	37	20	44477272	44477272	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:44477272C>T	uc002xqa.1	-	3	386	c.305G>A	c.(304-306)CGA>CAA	p.R102Q	ACOT8_uc010zxe.1_Missense_Mutation_p.R102Q|ACOT8_uc002xqc.1_Missense_Mutation_p.R49Q|ACOT8_uc010zxf.1_Intron	NM_005469	NP_005460	O14734	ACOT8_HUMAN	peroxisomal acyl-CoA thioesterase 1 isoform a	102					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|interspecies interaction between organisms|peroxisome organization	peroxisomal matrix	acetyl-CoA hydrolase activity|acyl-CoA thioesterase activity|carboxylesterase activity|choloyl-CoA hydrolase activity|protein binding			skin(1)	1		Myeloproliferative disorder(115;0.0122)				CGACCCTGTTCGTGTCCGCTC	0.627000													9	34					0	0	0.000673444	0	0
ZFP64	55734	broad.mit.edu	37	20	50769728	50769728	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:50769728G>A	uc002xwl.2	-	6	1352	c.1003C>T	c.(1003-1005)CGC>TGC	p.R335C	ZFP64_uc002xwk.2_Intron|ZFP64_uc002xwm.2_Missense_Mutation_p.R333C|ZFP64_uc002xwn.2_Missense_Mutation_p.R281C	NM_018197	NP_060667	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform a	335	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						TGGTGCACGCGGCTGTGCTTC	0.592000													31	64					0	0	0.00209593	0	0
NPBWR2	2832	broad.mit.edu	37	20	62737683	62737683	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:62737683G>A	uc011abt.1	-	1	502	c.502C>T	c.(502-504)CTG>TTG	p.L168L		NM_005286	NP_005277	P48146	NPBW2_HUMAN	neuropeptides B/W receptor 2	168	Helical; Name=4; (Potential).					plasma membrane	opioid receptor activity|protein binding			large_intestine(1)	1	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)					CAGACACACAGGCTGGCGACC	0.652000													7	26					0	0	0.000442599	0	0
RBM11	54033	broad.mit.edu	37	21	15592007	15592007	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr21:15592007C>T	uc002yjo.3	+	2	262	c.220C>T	c.(220-222)CGT>TGT	p.R74C	RBM11_uc002yjn.3_5'UTR|RBM11_uc002yjp.3_Intron	NM_144770	NP_658983	P57052	RBM11_HUMAN	RNA binding motif protein 11	74	RRM.						nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		GAATGGAATTCGTTTATATGG	0.388000													19	34					0	0	0.00074312	0	0
SYNJ1	8867	broad.mit.edu	37	21	34072313	34072313	+	Missense_Mutation	SNP	G	A	A	rs146507597		TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr21:34072313G>A	uc002yqh.2	-	4	431	c.431C>T	c.(430-432)TCA>TTA	p.S144L	SYNJ1_uc011ads.1_Missense_Mutation_p.S105L|SYNJ1_uc002yqf.2_Missense_Mutation_p.S105L|SYNJ1_uc002yqg.2_Missense_Mutation_p.S105L|SYNJ1_uc002yqi.2_Missense_Mutation_p.S144L	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	105							inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						GATTCGCAGTGATATAAACTC	0.383000													20	27					0	0	0.000958276	0	0
MX2	4600	broad.mit.edu	37	21	42778885	42778885	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr21:42778885C>T	uc002yzf.1	+	13	1969	c.1865C>T	c.(1864-1866)TCC>TTC	p.S622F	MX2_uc002yzg.1_Missense_Mutation_p.S345F|MX2_uc010gop.1_Missense_Mutation_p.S104F	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	622					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				TCGGTTTCCTCCTTTACTGAA	0.488000													16	32					0	0	0.00074312	0	0
AGPAT3	56894	broad.mit.edu	37	21	45402199	45402199	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr21:45402199C>T	uc002zdv.2	+	10	1279	c.1057C>T	c.(1057-1059)CGC>TGC	p.R353C	AGPAT3_uc002zdw.2_Missense_Mutation_p.R353C|AGPAT3_uc002zdx.2_Missense_Mutation_p.R440C|AGPAT3_uc002zdy.2_Missense_Mutation_p.R291C	NM_020132	NP_064517	Q9NRZ7	PLCC_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 3	353	Cytoplasmic (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0				STAD - Stomach adenocarcinoma(101;0.18)|Colorectal(79;0.24)		CTTTGGAGTTCGCAGACTGAT	0.448000													62	171					0	0	0.00361006	0	0
GGT1	2678	broad.mit.edu	37	22	25019805	25019805	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr22:25019805C>T	uc003aan.1	+	11	1429	c.942C>T	c.(940-942)CAC>CAT	p.H314H	GGT1_uc003aas.1_Silent_p.H314H|GGT1_uc003aat.1_Silent_p.H314H|GGT1_uc003aau.1_Silent_p.H314H|GGT1_uc003aav.1_Silent_p.H314H|GGT1_uc003aaw.1_Silent_p.H314H|GGT1_uc003aax.1_Silent_p.H314H	NM_013430	NP_038347	P19440	GGT1_HUMAN	gamma-glutamyltransferase 1 precursor	314	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding				0					Glutathione(DB00143)	TGACGTACCACCGCATCGTAG	0.617000													9	18					0	0	0.00136819	0	0
INPP5J	27124	broad.mit.edu	37	22	31522380	31522380	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr22:31522380G>A	uc003aju.3	+	3	1382	c.1290G>A	c.(1288-1290)TGG>TGA	p.W430*	INPP5J_uc010gwf.2_Nonsense_Mutation_p.W430*|INPP5J_uc003ajv.3_Nonsense_Mutation_p.W63*|INPP5J_uc003ajs.3_Nonsense_Mutation_p.W63*|INPP5J_uc011alk.1_Nonsense_Mutation_p.W363*|INPP5J_uc010gwg.2_5'UTR|INPP5J_uc003ajw.2_5'UTR|INPP5J_uc003ajt.3_Nonsense_Mutation_p.W62*|INPP5J_uc003ajx.2_5'Flank|INPP5J_uc003ajy.2_5'Flank|INPP5J_uc003ajz.2_5'Flank	NM_001002837	NP_001002837	Q15735	PI5PA_HUMAN	phosphatidylinositol (4,5) bisphosphate	430	Catalytic (Potential).					cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			skin(1)	1						TGGTCACATGGAACGTGGGCA	0.612000													45	94					0	0	0.00361006	0	0
PLXNB2	23654	broad.mit.edu	37	22	50721224	50721224	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr22:50721224G>A	uc003bkv.3	-	18	3009	c.2903C>T	c.(2902-2904)TCC>TTC	p.S968F	PLXNB2_uc003bkt.1_5'Flank|PLXNB2_uc003bku.1_5'Flank	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	968	Extracellular (Potential).|IPT/TIG 2.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGGCACGGGGGACCCCCCGTA	0.662000													8	25					0	0	0.000274275	0	0
ITPR1	3708	broad.mit.edu	37	3	4847917	4847918	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:4847917_4847918GG>AA	uc003bqa.2	+	52	7442_7443	c.7094_7095GG>AA	c.(7093-7095)GGG>GAA	p.G2365E	ITPR1_uc010hca.1_Missense_Mutation_p.G2350E|ITPR1_uc011asu.1_Missense_Mutation_p.G376E|ITPR1_uc003bqc.2_Missense_Mutation_p.G1335E|ITPR1_uc010hcc.1_Missense_Mutation_p.G133E|ITPR1_uc011asv.1_Missense_Mutation_p.G89E	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	2413	Helical; (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		TGTGCCATGGGGCTCTTTGTCC	0.465000													15	73					0	0	6.4e-05	0	0
SRGAP3	9901	broad.mit.edu	37	3	9166422	9166422	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:9166422C>T	uc003brf.1	-	2	923	c.247G>A	c.(247-249)GAG>AAG	p.E83K	SRGAP3_uc003brg.1_Missense_Mutation_p.E83K|SRGAP3_uc003bri.1_RNA|SRGAP3_uc003brk.2_Missense_Mutation_p.E83K	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	83	FCH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		AACTGGTGCTCCCGGGAGCTG	0.592000			T	RAF1	pilocytic astrocytoma								23	41					0	0	0.00332997	0	0
TADA3	10474	broad.mit.edu	37	3	9827025	9827025	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:9827025G>A	uc003bsx.1	-	7	1443	c.895C>T	c.(895-897)CCT>TCT	p.P299S	TADA3_uc010hcn.1_Missense_Mutation_p.P299S|TADA3_uc003bsy.2_Missense_Mutation_p.P299S|TADA3_uc003bsw.1_Missense_Mutation_p.P128S	NM_006354	NP_006345	O75528	TADA3_HUMAN	transcriptional adaptor 3 isoform a	299					estrogen receptor signaling pathway|histone H3 acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	ligand-dependent nuclear receptor binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity				0						TGATTGCGAGGGGAGGTGCTT	0.517000													19	39					0	0	0.00229938	0	0
ANKRD28	23243	broad.mit.edu	37	3	15719851	15719851	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:15719851G>A	uc003caj.1	-	24	2625	c.2482C>T	c.(2482-2484)CAT>TAT	p.H828Y	ANKRD28_uc003cai.1_Missense_Mutation_p.H674Y|ANKRD28_uc011avz.1_Missense_Mutation_p.H674Y|ANKRD28_uc003cak.1_RNA|ANKRD28_uc011awa.1_RNA|ANKRD28_uc011avy.1_5'Flank	NM_015199	NP_056014	O15084	ANR28_HUMAN	ankyrin repeat domain 28	828	ANK 24.					nucleoplasm	protein binding			breast(1)	1						GCGGCTGCATGGAGAGGAGTT	0.363000													9	61					0	0	0.00136819	0	0
THRB	7068	broad.mit.edu	37	3	24231772	24231772	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:24231772C>T	uc003ccx.3	-	5	425	c.76G>A	c.(76-78)GAC>AAC	p.D26N	THRB_uc010hfe.2_Missense_Mutation_p.D26N|THRB_uc003ccy.3_Missense_Mutation_p.D26N|THRB_uc003ccz.3_Missense_Mutation_p.D21N|THRB_uc003cdc.2_Missense_Mutation_p.D21N|THRB_uc003cdd.2_Missense_Mutation_p.D21N|THRB_uc003cde.1_Missense_Mutation_p.D21N	NM_001128176	NP_001121648	P10828	THB_HUMAN	thyroid hormone receptor, beta	26	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			skin(2)|pancreas(1)	3					Levothyroxine(DB00451)|Liothyronine(DB00279)	AGCTTCCAGTCGTGTTCTCGG	0.493000													17	83					0	0	0.00074312	0	0
SCN11A	11280	broad.mit.edu	37	3	38938447	38938447	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:38938447G>A	uc011ays.1	-	14	2491	c.2292C>T	c.(2290-2292)ATC>ATT	p.I764I	SCN11A_uc010hhn.1_5'Flank	NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	764	II.				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CCCCGCAGAGGATGCGGAATA	0.473000													10	32					0	0	0.000673444	0	0
IP6K2	51447	broad.mit.edu	37	3	48732679	48732679	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:48732679C>T	uc003cup.2	-	2	290	c.46G>A	c.(46-48)GGC>AGC	p.G16S	IP6K2_uc003cuq.2_Missense_Mutation_p.G16S|IP6K2_uc011bbq.1_Missense_Mutation_p.G16S|IP6K2_uc011bbr.1_Missense_Mutation_p.G16S|IP6K2_uc003cur.2_Missense_Mutation_p.G16S|IP6K2_uc003cus.2_Missense_Mutation_p.G16S|IP6K2_uc003cut.2_RNA|IP6K2_uc011bbs.1_RNA|IP6K2_uc011bbt.1_Missense_Mutation_p.G71S|IP6K2_uc003cuv.1_Missense_Mutation_p.R141K|IP6K2_uc011bbu.1_Missense_Mutation_p.G70S|IP6K2_uc011bbv.1_Missense_Mutation_p.G74S|IP6K2_uc003cuw.1_Missense_Mutation_p.R140K	NM_001005909	NP_001005909	Q9UHH9	IP6K2_HUMAN	inositol hexaphosphate kinase 2 isoform a	16					negative regulation of cell growth|phosphatidylinositol phosphorylation|positive regulation of apoptosis|type I interferon-mediated signaling pathway	intermediate filament cytoskeleton|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity				0						AGAAGGACGCCTTTGGCGCGG	0.662000													13	22					0	0	0.00185496	0	0
CCDC71	64925	broad.mit.edu	37	3	49200301	49200301	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:49200301G>A	uc003cwg.3	-	2	1479	c.1341C>T	c.(1339-1341)ATC>ATT	p.I447I		NM_022903	NP_075054	Q8IV32	CCD71_HUMAN	coiled-coil domain containing 71	447										ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TCACGCGGAGGATCCGCTGAG	0.557000													6	17					0	0	0.00198382	0	0
HEMK1	51409	broad.mit.edu	37	3	50614591	50614591	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:50614591C>T	uc003dau.2	+	5	819	c.523C>T	c.(523-525)CTC>TTC	p.L175F	HEMK1_uc003dav.2_Missense_Mutation_p.L175F|HEMK1_uc003daw.2_Missense_Mutation_p.L175F	NM_016173	NP_057257	Q9Y5R4	HEMK1_HUMAN	HemK methyltransferase family member 1	175					DNA methylation		DNA binding|N-methyltransferase activity|protein methyltransferase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000283)|KIRC - Kidney renal clear cell carcinoma(197;0.0179)|Kidney(197;0.0212)		AGCCATCTCCCTCAGCCTGCT	0.627000													10	50					0	0	0.000673444	0	0
DOCK3	1795	broad.mit.edu	37	3	51266179	51266179	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:51266179C>T	uc011bds.1	+	18	1758	c.1735C>T	c.(1735-1737)CCT>TCT	p.P579S		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	579	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CCCTAATATTCCTTCTAGCCT	0.478000													15	46					0	0	0.00244969	0	0
NEK4	6787	broad.mit.edu	37	3	52780790	52780790	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:52780790T>C	uc003dfq.3	-	9	1826	c.1637A>G	c.(1636-1638)CAC>CGC	p.H546R	NEK4_uc011bej.1_Missense_Mutation_p.H457R|NEK4_uc003dfr.2_Missense_Mutation_p.H500R	NM_003157	NP_003148	P51957	NEK4_HUMAN	NIMA-related kinase 4	546					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		TTCCCCTCTGTGCTCAGTCTG	0.483000													24	38					0	0	0.00106085	0	0
VGLL3	389136	broad.mit.edu	37	3	87018250	87018250	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:87018250G>A	uc003dqn.2	-	3	791	c.427C>T	c.(427-429)CGG>TGG	p.R143W		NM_016206	NP_057290	A8MV65	VGLL3_HUMAN	colon carcinoma related protein	143					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		AAACTATTCCGCTGGCTTGAG	0.478000													80	97					0	0	0.00361006	0	0
MORC1	27136	broad.mit.edu	37	3	108724118	108724118	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:108724118C>T	uc003dxl.2	-	19	1899	c.1812G>A	c.(1810-1812)TTG>TTA	p.L604L	MORC1_uc011bhn.1_Silent_p.L583L	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	604					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						ATTCATGCTTCAAGTCATCGC	0.343000													16	35					0	0	0.000566183	0	0
SIDT1	54847	broad.mit.edu	37	3	113300282	113300282	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:113300282C>T	uc003eak.2	+	6	1389	c.738C>T	c.(736-738)ATC>ATT	p.I246I	SIDT1_uc011bif.1_RNA|SIDT1_uc003eaj.1_Silent_p.I246I|SIDT1_uc011big.1_5'UTR	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	246	Extracellular (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						AAGCTGCCATCACGCTACAGG	0.468000													22	35					0	0	0.00229938	0	0
C3orf30	152405	broad.mit.edu	37	3	118866052	118866052	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:118866052A>C	uc003ecb.1	+	1	1056	c.1016A>C	c.(1015-1017)CAC>CCC	p.H339P	IGSF11_uc003eby.2_5'Flank|IGSF11_uc003ebz.2_5'Flank|IGSF11_uc010hqs.2_5'Flank|C3orf30_uc011biw.1_Missense_Mutation_p.H339P	NM_152539	NP_689752	Q96M34	CC030_HUMAN	hypothetical protein LOC152405	339										ovary(2)	2				GBM - Glioblastoma multiforme(114;0.222)		GACAATGCTCACTACACTGAA	0.468000													17	31					0	0	0.00188189	0	0
CCDC37	348807	broad.mit.edu	37	3	126138654	126138654	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:126138654G>A	uc003eiu.1	+	9	1005	c.906G>A	c.(904-906)GGG>GGA	p.G302G	CCDC37_uc010hsg.1_Silent_p.G303G	NM_182628	NP_872434	Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	302										ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.166)		CCACACCAGGGGACAAAGGTA	0.547000													4	36					0	0	0.000602214	0	0
CPB1	1360	broad.mit.edu	37	3	148577630	148577630	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:148577630G>A	uc003ewl.2	+	11	1118	c.1095G>A	c.(1093-1095)TGG>TGA	p.W365*		NM_001871	NP_001862	P15086	CBPB1_HUMAN	pancreatic carboxypeptidase B1 preproprotein	365					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			CTGACGACTGGGCTTATGACC	0.448000													24	56					0	0	0.00332997	0	0
KCNAB1	7881	broad.mit.edu	37	3	156139410	156139410	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:156139410T>C	uc003far.2	+	2	345	c.281T>C	c.(280-282)CTT>CCT	p.L94P	KCNAB1_uc011bon.1_Missense_Mutation_p.L94P|KCNAB1_uc003fas.2_Missense_Mutation_p.L83P|KCNAB1_uc003fat.2_Missense_Mutation_p.L76P|KCNAB1_uc010hvt.1_Missense_Mutation_p.L76P	NM_172160	NP_751892	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related	94						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			TATAGGAATCTTGGAAAATCA	0.463000													32	90					0	0	0.00327116	0	0
SAMD7	344658	broad.mit.edu	37	3	169656266	169656266	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:169656266G>A	uc003fgd.2	+	9	1580	c.1313G>A	c.(1312-1314)GGA>GAA	p.G438E	SAMD7_uc003fge.2_Missense_Mutation_p.G438E|SAMD7_uc011bpo.1_Missense_Mutation_p.G339E	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	438										skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			ATTCCTAAAGGAATTGAGCGA	0.408000													9	17					0	0	0.00136819	0	0
AHSG	197	broad.mit.edu	37	3	186338685	186338685	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:186338685C>T	uc003fqk.3	+	7	1151	c.1070C>T	c.(1069-1071)CCA>CTA	p.P357L	AHSG_uc003fql.3_Missense_Mutation_p.P358L|AHSG_uc003fqm.3_Missense_Mutation_p.P356L|AHSG_uc010hyp.2_Missense_Mutation_p.P320L	NM_001622	NP_001613	P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	357					acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding				0	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		GTGGTTCCTCCATGTCCGGGG	0.562000													12	27					0	0	0.000978159	0	0
C3orf59	151963	broad.mit.edu	37	3	192517371	192517371	+	Missense_Mutation	SNP	G	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:192517371G>C	uc011bsp.1	-	2	601	c.280C>G	c.(280-282)CGG>GGG	p.R94G		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	94											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		ACGCCTTCCCGGACACCTCCA	0.473000													12	25					0	0	0.00244969	0	0
LRRC33	375387	broad.mit.edu	37	3	196381472	196381472	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:196381472A>G	uc003fwv.2	+	2	166	c.62A>G	c.(61-63)AAC>AGC	p.N21S		NM_198565	NP_940967	Q86YC3	LRC33_HUMAN	leucine rich repeat containing 33 precursor	21	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.9e-23)|all cancers(36;1.76e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		GGCTGGAGGAACAGAAGCGGA	0.577000													18	49					0	0	0.000958276	0	0
DLG1	1739	broad.mit.edu	37	3	196792579	196792579	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:196792579G>A	uc003fxo.3	-	22	2423	c.2233C>T	c.(2233-2235)CAT>TAT	p.H745Y	DLG1_uc011bub.1_Missense_Mutation_p.H641Y|DLG1_uc011buc.1_Missense_Mutation_p.H629Y|DLG1_uc011bud.1_Missense_Mutation_p.H428Y|DLG1_uc003fxn.3_Missense_Mutation_p.H767Y|DLG1_uc011bue.1_Missense_Mutation_p.H733Y|DLG1_uc010ial.2_Missense_Mutation_p.H745Y	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	745	Guanylate kinase-like.				actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		GTTTACTTACGAGGAACACAG	0.328000													18	32					0	0	0.00121646	0	0
ZNF732	654254	broad.mit.edu	37	4	289909	289909	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:289909G>A	uc011buu.1	-	1	50	c.36C>T	c.(34-36)TTC>TTT	p.F12F	ZNF732_uc010ibb.1_Intron	NM_001137608	NP_001131080	B4DXR9	ZN732_HUMAN	zinc finger protein 732	13	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTCTGGAGAGAATTCTATGG	0.418000													10	36					0	0	0.000978159	0	0
SLC34A2	10568	broad.mit.edu	37	4	25678062	25678062	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:25678062G>A	uc003grr.2	+	13	1845	c.1764G>A	c.(1762-1764)CAG>CAA	p.Q588Q	SLC34A2_uc003grs.2_Silent_p.Q587Q|SLC34A2_uc010iev.2_Silent_p.Q587Q	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	588	Cytoplasmic (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				AGAAACTCCAGAACTGGAACT	0.562000													38	91					0	0	0.0025221	0	0
ARAP2	116984	broad.mit.edu	37	4	36212304	36212304	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:36212304G>A	uc003gsq.1	-	6	1533	c.1195C>T	c.(1195-1197)CGA>TGA	p.R399*	ARAP2_uc003gsr.1_Nonsense_Mutation_p.R399*	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	399					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						TTGTCCTCTCGAGGTATCCAA	0.338000													44	123					0	0	0.00361006	0	0
CHRNA9	55584	broad.mit.edu	37	4	40356123	40356123	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:40356123G>A	uc003gva.1	+	5	1042	c.1026G>A	c.(1024-1026)CTG>CTA	p.L342L		NM_017581	NP_060051	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9	342	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(3)|skin(3)|central_nervous_system(1)	7					Nicotine(DB00184)	TGGTCATCCTGAAATACATGT	0.557000													86	168					0	0	0.00361006	0	0
ATP10D	57205	broad.mit.edu	37	4	47514588	47514588	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:47514588C>T	uc003gxk.1	+	2	195	c.31C>T	c.(31-33)CAC>TAC	p.H11Y	ATP10D_uc003gxj.3_Missense_Mutation_p.H11Y	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	11	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						GGCCAGATATCACTGGCGACG	0.522000													29	53					0	0	0.00283554	0	0
KDR	3791	broad.mit.edu	37	4	55984967	55984967	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:55984967C>T	uc003has.2	-	3	464	c.162G>A	c.(160-162)AGG>AGA	p.R54R	KDR_uc003hat.1_Silent_p.R54R|KDR_uc011bzx.1_Silent_p.R54R	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	54	Ig-like C2-type 1.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CCCTCTGTCCCCTGAAAAATT	0.428000			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			22	48					0	0	0.00332997	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68780325	68780325	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:68780325C>T	uc003hdr.1	-	9	1206	c.1085G>A	c.(1084-1086)GGA>GAA	p.G362E	LOC550112_uc003hdl.3_Intron|TMPRSS11A_uc003hds.1_Missense_Mutation_p.G359E	NM_182606	NP_872412	Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A isoform 1	362	Peptidase S1.|Extracellular (Potential).				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			skin(1)	1						ATCATAAATTCCTTCCATATA	0.358000													44	68					0	0	0.00361006	0	0
UGT2B15	7366	broad.mit.edu	37	4	69535870	69535870	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:69535870G>A	uc011cal.1	-	1	505	c.467C>T	c.(466-468)CCC>CTC	p.P156L		NM_001076	NP_001067	P54855	UDB15_HUMAN	UDP glycosyltransferase 2B15 precursor	156					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity				0						CTCACCACAGGGATTAAGGGC	0.393000													92	244					0	0	0.00361006	0	0
UGT2B7	7364	broad.mit.edu	37	4	69973826	69973826	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:69973826C>T	uc003heg.3	+	5	1142	c.1096C>T	c.(1096-1098)CCA>TCA	p.P366S	UGT2B7_uc010ihq.2_Intron	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	366					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						CCTAGGTCATCCAAAGACCAG	0.418000													31	71					0	0	0.00178596	0	0
UGT2B4	7363	broad.mit.edu	37	4	70359494	70359494	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:70359494C>T	uc003hek.3	-	2	834	c.787G>A	c.(787-789)GAT>AAT	p.D263N	UGT2B4_uc011cap.1_Missense_Mutation_p.D127N|UGT2B4_uc003hel.3_Missense_Mutation_p.D263N	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	263					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						AATTGAAAATCCCAGTAGTTT	0.418000													19	60					0	0	0.00074312	0	0
CSN2	1447	broad.mit.edu	37	4	70823276	70823276	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:70823276G>A	uc003hes.3	-	5	404	c.391C>T	c.(391-393)CCA>TCA	p.P131S	CSN2_uc003het.3_Missense_Mutation_p.P130S	NM_001891	NP_001882	P05814	CASB_HUMAN	casein beta precursor	131					calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity				0						GTGAGTTTTGGGATTTGAGGG	0.468000													13	45					0	0	0.00185496	0	0
STBD1	8987	broad.mit.edu	37	4	77231024	77231024	+	Missense_Mutation	SNP	T	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:77231024T>G	uc003hka.2	+	2	1194	c.948T>G	c.(946-948)GAT>GAG	p.D316E	STBD1_uc003hjy.2_3'UTR|STBD1_uc011cbv.1_3'UTR|STBD1_uc011cbw.1_Missense_Mutation_p.D167E	NM_003943	NP_003934	O95210	STBD1_HUMAN	starch binding domain 1	316	CBM20.|Cytoplasmic (Potential).				carbohydrate metabolic process|muscle contraction	integral to plasma membrane|membrane fraction	carbohydrate binding|catalytic activity|protein binding			ovary(1)	1			Lung(101;0.196)			TGCCTGCAGATACAGTGGTGG	0.473000													17	73					0	0	0.00074312	0	0
BMP3	651	broad.mit.edu	37	4	81966994	81966994	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:81966994G>A	uc003hmg.3	+	2	739	c.419G>A	c.(418-420)GGA>GAA	p.G140E		NM_001201	NP_001192	P12645	BMP3_HUMAN	bone morphogenetic protein 3 preproprotein	140					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(4)|central_nervous_system(1)	5						GGAGAGCTAGGAAACATCAGC	0.428000													24	71					0	0	0.00278032	0	0
ANK2	287	broad.mit.edu	37	4	114275410	114275410	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:114275410C>T	uc003ibe.3	+	38	5736	c.5636C>T	c.(5635-5637)TCA>TTA	p.S1879L	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.S1894L	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1846	Repeat A.|Repeat-rich region.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GAGAAACACTCACCTGTATCA	0.443000													47	103					0	0	0.00361006	0	0
IL21	59067	broad.mit.edu	37	4	123542116	123542116	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:123542116G>A	uc003ies.2	-	1	96	c.51C>T	c.(49-51)GTC>GTT	p.V17V	uc003iet.2_RNA|IL21_uc010int.2_Silent_p.V10V	NM_021803	NP_068575	Q9HBE4	IL21_HUMAN	interleukin 21	10					cell maturation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-17 production|positive regulation of T cell proliferation|signal transduction	extracellular space	cytokine activity|interleukin-2 receptor binding				0						CCAAGAAGATGACCATCAGAC	0.443000													27	52					0	0	0.000878237	0	0
LRBA	987	broad.mit.edu	37	4	151388908	151388908	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:151388908G>A	uc010ipj.2	-	45	7204	c.6730C>T	c.(6730-6732)CCA>TCA	p.P2244S	LRBA_uc010ipi.2_5'UTR|LRBA_uc003ils.3_Missense_Mutation_p.P134S|LRBA_uc003ilt.3_Missense_Mutation_p.P892S|LRBA_uc003ilu.3_Missense_Mutation_p.P2233S	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2244	BEACH.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					GGAAACACTGGATACTGATTT	0.323000													19	58					0	0	0.00188189	0	0
LRBA	987	broad.mit.edu	37	4	151392883	151392883	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:151392883G>A	uc010ipj.2	-	44	7067	c.6593C>T	c.(6592-6594)TCA>TTA	p.S2198L	LRBA_uc003ils.3_Missense_Mutation_p.S88L|LRBA_uc003ilt.3_Missense_Mutation_p.S846L|LRBA_uc003ilu.3_Missense_Mutation_p.S2187L	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2198						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					ACTAGCTAATGAAATACGTCT	0.313000													30	61					0	0	0.00283554	0	0
FGA	2243	broad.mit.edu	37	4	155506800	155506800	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:155506800G>A	uc003iod.1	-	5	1839	c.1781C>T	c.(1780-1782)TCC>TTC	p.S594F	FGA_uc003ioe.1_Missense_Mutation_p.S594F|FGA_uc003iof.1_3'UTR	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	594	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TTCAAATGTGGAGTCTCCTCT	0.453000													24	65					0	0	0.00332997	0	0
NAF1	92345	broad.mit.edu	37	4	164066932	164066932	+	Splice_Site	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:164066932A>G	uc003iqj.2	-	4	911	c.717_splice	c.e4+1	p.K239_splice	NAF1_uc010iqw.1_Splice_Site_p.K239_splice	NM_138386	NP_612395	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 homolog isoform a						rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			ovary(2)	2	all_hematologic(180;0.166)	Prostate(90;0.109)				TGTTTTACAAACCTTTCCTGC	0.274000													3	8					0	0	6.4e-05	0	0
NPY5R	4889	broad.mit.edu	37	4	164272238	164272238	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:164272238C>T	uc003iqn.2	+	4	995	c.813C>T	c.(811-813)CTC>CTT	p.L271L		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	271	Cytoplasmic (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				AGGTGAAACTCTCTGGCAGCC	0.398000													19	69					0	0	0.00152264	0	0
TLL1	7092	broad.mit.edu	37	4	166996071	166996071	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:166996071G>A	uc003irh.1	+	17	2877	c.2230G>A	c.(2230-2232)GAA>AAA	p.E744K	TLL1_uc011cjn.1_Missense_Mutation_p.E767K|TLL1_uc011cjo.1_Missense_Mutation_p.E568K	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	744	EGF-like 2; calcium-binding (Potential).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		ATGTCAGCACGAATGTGTCAA	0.393000													23	65					0	0	0.00229938	0	0
C4orf41	60684	broad.mit.edu	37	4	184589218	184589218	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:184589218A>G	uc003ivx.2	+	5	684	c.508A>G	c.(508-510)AAG>GAG	p.K170E	C4orf41_uc003ivw.2_Missense_Mutation_p.K170E|C4orf41_uc010isc.2_Intron	NM_021942	NP_068761	Q7Z392	CD041_HUMAN	hypothetical protein LOC60684 isoform a	170											0		all_lung(41;4.4e-14)|Lung NSC(41;1.03e-13)|Colorectal(36;0.00139)|all_hematologic(60;0.00756)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.39e-26)|Epithelial(43;2.42e-22)|OV - Ovarian serous cystadenocarcinoma(60;6.85e-10)|GBM - Glioblastoma multiforme(59;6.71e-06)|Colorectal(24;9.67e-06)|STAD - Stomach adenocarcinoma(60;2.36e-05)|COAD - Colon adenocarcinoma(29;7.07e-05)|LUSC - Lung squamous cell carcinoma(40;0.00984)|READ - Rectum adenocarcinoma(43;0.171)		ACTCTCAGGAAAGTCTTTGTT	0.358000													55	116					0	0	0.00361006	0	0
FAT1	2195	broad.mit.edu	37	4	187541133	187541133	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:187541133G>A	uc003izf.2	-	10	6795	c.6607C>T	c.(6607-6609)CAC>TAC	p.H2203Y		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2203	Extracellular (Potential).|Cadherin 20.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GCCTGCACGTGGACCACAGGG	0.488000										HNSCC(5;0.00058)			33	99					0	0	0.000953801	0	0
FBXL7	23194	broad.mit.edu	37	5	15928108	15928108	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:15928108C>T	uc003jfn.1	+	3	718	c.237C>T	c.(235-237)TCC>TCT	p.S79S		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	79					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						CCTCGTCCTCCATCACCGGGG	0.657000													13	11					0	0	0.00185496	0	0
MARCH11	441061	broad.mit.edu	37	5	16067614	16067614	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:16067614G>A	uc003jfo.2	-	4	1388	c.1175C>T	c.(1174-1176)TCG>TTG	p.S392L	MARCH11_uc010itw.1_Missense_Mutation_p.S148L	NM_001102562	NP_001096032	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	392						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding				0						AACCTCCCCCGAGCTGTTATC	0.463000													67	78					0	0	0.00361006	0	0
CDH18	1016	broad.mit.edu	37	5	19520879	19520879	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:19520879C>T	uc003jgc.2	-	9	1776	c.1399G>A	c.(1399-1401)GAT>AAT	p.D467N	CDH18_uc003jgd.2_Missense_Mutation_p.D467N|CDH18_uc011cnm.1_Missense_Mutation_p.D467N	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	467	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CTCAGCAAATCAGGATTATCT	0.373000													33	48					0	0	0.00222228	0	0
PRLR	5618	broad.mit.edu	37	5	35065851	35065851	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:35065851G>A	uc003jjm.2	-	10	1739	c.1209C>T	c.(1207-1209)ATC>ATT	p.I403I	PRLR_uc003jjg.1_Intron|PRLR_uc003jjh.1_Intron|PRLR_uc003jji.1_Intron|PRLR_uc003jjj.1_Intron|PRLR_uc003jjk.1_Intron|PRLR_uc003jjl.3_Silent_p.I302I	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	403	Cytoplasmic (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	GAAAATAGGGGATTTTGCCTT	0.488000													59	138					0	0	0.00361006	0	0
SPEF2	79925	broad.mit.edu	37	5	35727804	35727804	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:35727804G>A	uc003jjo.2	+	21	3053	c.2942G>A	c.(2941-2943)GGA>GAA	p.G981E	SPEF2_uc003jjp.1_Missense_Mutation_p.G467E	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	981					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TCATCAGGAGGAAAAGTACCA	0.388000													17	35					0	0	0.00400662	0	0
NIPBL	25836	broad.mit.edu	37	5	37052538	37052538	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:37052538C>T	uc003jkl.3	+	42	7632	c.7133C>T	c.(7132-7134)CCT>CTT	p.P2378L	NIPBL_uc003jkk.3_Missense_Mutation_p.P2378L|NIPBL_uc003jkn.2_Missense_Mutation_p.P71L	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	2378					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CTAAAAGATCCTGTAAGGGGT	0.433000													18	39					0	0	0.00074312	0	0
DAB2	1601	broad.mit.edu	37	5	39381617	39381617	+	Silent	SNP	G	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:39381617G>C	uc003jlx.2	-	11	1974	c.1443C>G	c.(1441-1443)CCC>CCG	p.P481P	DAB2_uc003jlw.2_Silent_p.P460P	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	481					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			CCAGAGGGTTGGGCTGCAGGG	0.537000													28	96					0	0	0.00209593	0	0
CD180	4064	broad.mit.edu	37	5	66479863	66479863	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:66479863C>T	uc003juy.2	-	3	956	c.808G>A	c.(808-810)GGA>AGA	p.G270R		NM_005582	NP_005573	Q99467	CD180_HUMAN	CD180 molecule precursor	270	Extracellular (Potential).				inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			ovary(1)	1		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		TCACAGAGTCCCTTGAGCATG	0.453000													14	19					0	0	0.000566183	0	0
MSH3	4437	broad.mit.edu	37	5	80057454	80057454	+	Missense_Mutation	SNP	T	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:80057454T>G	uc003kgz.2	+	13	2106	c.1853T>G	c.(1852-1854)TTG>TGG	p.L618W		NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	618					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		CTACGTAAATTGCCCGACATA	0.393000								MMR					11	28					0	0	0.00244969	0	0
GPR98	84059	broad.mit.edu	37	5	89979723	89979723	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:89979723G>A	uc003kju.2	+	28	6081	c.5985G>A	c.(5983-5985)CAG>CAA	p.Q1995Q	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1995	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AAGCAACCCAGAACATCACAC	0.368000													11	6					0	0	0.000978159	0	0
ELL2	22936	broad.mit.edu	37	5	95226829	95226829	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:95226829G>A	uc003klr.3	-	10	2089	c.1739C>T	c.(1738-1740)TCT>TTT	p.S580F		NM_012081	NP_036213	O00472	ELL2_HUMAN	elongation factor, RNA polymerase II, 2	580					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				central_nervous_system(1)	1		all_cancers(142;2.04e-06)|all_epithelial(76;3.1e-09)|all_lung(232;0.00309)|Lung NSC(167;0.00454)|Ovarian(225;0.0165)|Colorectal(57;0.0343)|Breast(839;0.198)		all cancers(79;2.16e-15)		TGAGCCTGGAGAAAGGCGCTT	0.428000													39	66					0	0	0.0025221	0	0
SNCAIP	9627	broad.mit.edu	37	5	121759022	121759022	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:121759022C>T	uc003ksw.1	+	4	796	c.590C>T	c.(589-591)TCT>TTT	p.S197F	SNCAIP_uc011cwl.1_Intron|SNCAIP_uc010jct.2_Missense_Mutation_p.S197F|SNCAIP_uc003ksx.1_Missense_Mutation_p.S244F|SNCAIP_uc003ksy.1_Intron|SNCAIP_uc003ksz.1_Intron|SNCAIP_uc010jcu.2_Intron|SNCAIP_uc011cwm.1_Intron|SNCAIP_uc003kta.1_Intron|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Intron|SNCAIP_uc010jcx.1_Missense_Mutation_p.S197F	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	197					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		ACAGGAAGTTCTGAGAGCTCA	0.463000													45	53					0	0	0.0025221	0	0
PCDHB9	56127	broad.mit.edu	37	5	140567041	140567041	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:140567041A>T	uc003liw.1	+	1	149	c.149A>T	c.(148-150)AAG>ATG	p.K50M		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	50	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AATCTGGCAAAGGATCTGGGA	0.502000													22	15					0	0	0.00327116	0	0
PCDHB14	56122	broad.mit.edu	37	5	140605400	140605400	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:140605400C>T	uc003ljb.2	+	1	2323	c.2323C>T	c.(2323-2325)CAA>TAA	p.Q775*	PCDHB14_uc011dal.1_Nonsense_Mutation_p.Q622*	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	775	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCCAATTTTCAAGTTCATGA	0.403000													16	40					0	0	0.000566183	0	0
PCDHGA9	56107	broad.mit.edu	37	5	140784766	140784766	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:140784766C>T	uc003lkh.1	+	1	2247	c.2247C>T	c.(2245-2247)TTC>TTT	p.F749F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Silent_p.F749F	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	749	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCGAGCTTTCCTACAGACCT	0.567000													37	27					0	0	0.00375469	0	0
HTR4	3360	broad.mit.edu	37	5	147929700	147929700	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:147929700C>T	uc003lpn.2	-	3	316	c.152G>A	c.(151-153)AGG>AAG	p.R51K	HTR4_uc010jgu.1_RNA|HTR4_uc003lpi.1_Missense_Mutation_p.R51K|HTR4_uc003lpj.1_Missense_Mutation_p.R51K|HTR4_uc003lpk.2_Missense_Mutation_p.R51K|HTR4_uc011dby.1_Missense_Mutation_p.R51K|HTR4_uc003lpl.2_Missense_Mutation_p.R51K|HTR4_uc003lpm.2_Missense_Mutation_p.R51K|HTR4_uc010jgv.2_RNA|HTR4_uc003lpo.1_Missense_Mutation_p.R51K|SH3TC2_uc003lpp.1_RNA	NM_000870	NP_000861	Q13639	5HT4R_HUMAN	serotonin 5-HT4 receptor isoform b	51	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	TGCTGCTCACCTGAGCTGCCT	0.502000													12	12					0	0	0.00136819	0	0
CDHR2	54825	broad.mit.edu	37	5	176002198	176002198	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:176002198G>A	uc003mem.1	+	8	675	c.609G>A	c.(607-609)GAG>GAA	p.E203E	CDHR2_uc003men.1_Silent_p.E203E	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	203	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						ACCAGCTGGAGCTGAAGGCCT	0.637000													39	42					0	0	0.0025221	0	0
TUBB2A	7280	broad.mit.edu	37	6	3155866	3155866	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:3155866G>A	uc003mvc.2	-	3	356	c.270C>T	c.(268-270)TTC>TTT	p.F90F	TUBB2A_uc003mvb.2_Silent_p.F83F|TUBB2A_uc003mvd.2_Intron	NM_001069	NP_001060	Q13885	TBB2A_HUMAN	tubulin, beta 2	90					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			skin(1)	1	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				TACCGAACACGAAGTTGTCTG	0.517000													10	32					0	0	0.00136819	0	0
DSP	1832	broad.mit.edu	37	6	7583542	7583542	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:7583542G>A	uc003mxp.1	+	24	6326	c.6047G>A	c.(6046-6048)GGA>GAA	p.G2016E	DSP_uc003mxq.1_Missense_Mutation_p.G1417E	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2016	Plectin 1.|Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CGGGGTGCAGGATCTATCGCT	0.453000													18	51					0	0	0.000566183	0	0
DSP	1832	broad.mit.edu	37	6	7584933	7584933	+	Missense_Mutation	SNP	C	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:7584933C>A	uc003mxp.1	+	24	7717	c.7438C>A	c.(7438-7440)CAG>AAG	p.Q2480K	DSP_uc003mxq.1_Missense_Mutation_p.Q1881K	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2480	Plectin 12.|Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AATGTCTGTTCAGGAGGCCTA	0.423000													49	83					2.30037e-20	8.14126e-20	0.00361006	1	0
ZNF192	7745	broad.mit.edu	37	6	28119712	28119712	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:28119712C>T	uc003nkn.1	+	4	833	c.649C>T	c.(649-651)CAG>TAG	p.Q217*	ZNF192_uc010jqx.1_Nonsense_Mutation_p.Q217*|ZNF192_uc010jqy.1_Nonsense_Mutation_p.Q30*|ZNF192_uc011dkz.1_Nonsense_Mutation_p.Q30*	NM_006298	NP_006289	Q15776	ZN192_HUMAN	zinc finger protein 192	217					viral reproduction	cytoplasm|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGCAGGGTTCCAGGTGAGTTG	0.493000													25	44					0	0	0.00127121	0	0
OR2J2	26707	broad.mit.edu	37	6	29141462	29141462	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:29141462G>A	uc011dlm.1	+	1	152	c.50G>A	c.(49-51)GGA>GAA	p.G17E		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	17	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATTCTACTTGGATTTTCTAAT	0.358000													42	108					0	0	0.00321405	0	0
BAT3	7917	broad.mit.edu	37	6	31615563	31615563	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:31615563G>A	uc003nvg.3	-	7	925	c.611C>T	c.(610-612)CCG>CTG	p.P204L	BAT3_uc003nvf.3_Missense_Mutation_p.P198L|BAT3_uc003nvh.3_Missense_Mutation_p.P198L|BAT3_uc003nvi.3_Missense_Mutation_p.P198L|BAT3_uc011dnw.1_Missense_Mutation_p.P198L|BAT3_uc011dnx.1_Missense_Mutation_p.P198L|BAT3_uc003nvj.1_Missense_Mutation_p.P198L	NM_004639	NP_004630	P46379	BAG6_HUMAN	HLA-B associated transcript-3 isoform a	204	Pro-rich.				apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding				0						CGGTGGCTGCGGGGGCGGCTG	0.602000													155	337					0	0	0.00361006	0	0
TNXB	7148	broad.mit.edu	37	6	32013006	32013006	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:32013006G>A	uc003nzl.2	-	32	10900	c.10698C>T	c.(10696-10698)ACC>ACT	p.T3566T	TNXB_uc003nzg.1_5'UTR|TNXB_uc003nzh.1_Silent_p.T35T	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3613	Fibronectin type-III 28.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TGGAGTCTGGGGTTGTGTCGG	0.652000													46	281					0	0	0.00361006	0	0
COL11A2	1302	broad.mit.edu	37	6	33132137	33132137	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:33132137G>A	uc003ocx.1	-	65	5205	c.4977C>T	c.(4975-4977)GCC>GCT	p.A1659A	COL11A2_uc010jul.1_Silent_p.A229A|COL11A2_uc003ocy.1_Silent_p.A1573A|COL11A2_uc003ocz.1_Silent_p.A1552A	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	1659	Fibrillar collagen NC1.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						GACCGTCACGGGCTGCTCCAG	0.627000													4	17					0	0	0.000602214	0	0
SNRPC	6631	broad.mit.edu	37	6	34741275	34741275	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:34741275C>T	uc003ojt.1	+	6	423	c.408C>T	c.(406-408)CCC>CCT	p.P136P		NM_003093	NP_003084	P09234	RU1C_HUMAN	small nuclear ribonucleoprotein polypeptide C	136					spliceosomal snRNP assembly	Cajal body|U1 snRNP	protein homodimerization activity|single-stranded RNA binding|zinc ion binding			pancreas(1)	1						TGCCTGGGCCCCCAATGATGA	0.552000													17	43					0	0	0.000566183	0	0
DNAH8	1769	broad.mit.edu	37	6	38825330	38825330	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:38825330G>A	uc003ooe.1	+	40	5719	c.5119G>A	c.(5119-5121)GAT>AAT	p.D1707N		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GTGGACACACGATTCAGAAGA	0.343000													15	52					0	0	0.00316338	0	0
DNAH8	1769	broad.mit.edu	37	6	38830135	38830135	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:38830135G>A	uc003ooe.1	+	42	6160	c.5560G>A	c.(5560-5562)GAA>AAA	p.E1854K		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TGGCAAAACAGAAACCACAAA	0.463000													35	67					0	0	0.00428921	0	0
DNAH8	1769	broad.mit.edu	37	6	38854607	38854607	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:38854607G>A	uc003ooe.1	+	55	8249	c.7649G>A	c.(7648-7650)GGA>GAA	p.G2550E		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GAAATGGAAGGAATGTACAGC	0.398000													12	55					0	0	0.00185496	0	0
DNAH8	1769	broad.mit.edu	37	6	38875794	38875794	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:38875794G>A	uc003ooe.1	+	62	9360	c.8760G>A	c.(8758-8760)ATG>ATA	p.M2920I	uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TTTCAGTGATGAAGAGGGAGC	0.398000													23	63					0	0	0.00332997	0	0
KCNK17	89822	broad.mit.edu	37	6	39272353	39272353	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:39272353T>C	uc003ooo.2	-	3	571	c.431A>G	c.(430-432)AAC>AGC	p.N144S	KCNK17_uc003oop.2_Missense_Mutation_p.N144S	NM_031460	NP_113648	Q96T54	KCNKH_HUMAN	potassium channel, subfamily K, member 17	144	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2						CACCACGAGGTTGAGTGGGAT	0.632000													41	92					0	0	0.00321405	0	0
TREML2	79865	broad.mit.edu	37	6	41162268	41162268	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:41162268G>A	uc010jxm.1	-	3	859	c.680C>T	c.(679-681)TCC>TTC	p.S227F		NM_024807	NP_079083	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid	227	Extracellular (Potential).				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					AGTGGAGATGGATTCTGGGCC	0.627000													9	17					0	0	0.000442599	0	0
DEFB114	245928	broad.mit.edu	37	6	49928133	49928133	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:49928133G>A	uc011dwp.1	-	2	82	c.82C>T	c.(82-84)CGT>TGT	p.R28C		NM_001037499	NP_001032588	Q30KQ6	DB114_HUMAN	beta-defensin 114 precursor	28					defense response to bacterium	extracellular region				ovary(1)	1	Lung NSC(77;0.042)					TTGGTGCAACGATCAGCATTC	0.353000													15	30					0	0	0.00400662	0	0
PKHD1	5314	broad.mit.edu	37	6	51524233	51524233	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:51524233G>A	uc003pah.1	-	61	10967	c.10691C>T	c.(10690-10692)GCC>GTC	p.A3564V		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3564	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CACAGTGAGGGCCAAGTGAAT	0.408000													13	53					0	0	0.00136819	0	0
MRAP2	112609	broad.mit.edu	37	6	84765113	84765113	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:84765113G>A	uc003pkg.3	+	2	266	c.76G>A	c.(76-78)GAA>AAA	p.E26K	MRAP2_uc010kbo.2_5'UTR	NM_138409	NP_612418	Q96G30	MRAP2_HUMAN	melanocortin 2 receptor accessory protein 2	26					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding			skin(2)	2						CTGGGAATATGAATATTATGA	0.383000													13	54					0	0	0.00136819	0	0
C6orf165	154313	broad.mit.edu	37	6	88119576	88119576	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:88119576G>A	uc003plv.2	+	2	111	c.19G>A	c.(19-21)GAA>AAA	p.E7K	C6orf165_uc003plw.2_5'UTR|C6orf165_uc010kbv.1_RNA|C6orf165_uc003plu.1_Missense_Mutation_p.E7K	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	7										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		AACTCAGGCCGAAAGTGTTAT	0.333000													21	58					0	0	0.00229938	0	0
C6orf165	154313	broad.mit.edu	37	6	88173827	88173827	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:88173827G>A	uc003plv.2	+	13	1820	c.1728G>A	c.(1726-1728)AAG>AAA	p.K576K	SLC35A1_uc003plx.2_RNA|C6orf165_uc003plw.2_Silent_p.K388K|C6orf165_uc010kbv.1_RNA	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	576										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		ACCCTCCAAAGGACACTAGCA	0.478000													15	27					0	0	0.00316338	0	0
KLHL32	114792	broad.mit.edu	37	6	97561953	97561953	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:97561953C>T	uc010kcm.1	+	7	1394	c.922C>T	c.(922-924)CGG>TGG	p.R308W	KLHL32_uc003poy.2_Missense_Mutation_p.R308W|KLHL32_uc011ead.1_Missense_Mutation_p.R272W|KLHL32_uc003poz.2_Intron|KLHL32_uc011eae.1_Missense_Mutation_p.R239W|KLHL32_uc003ppa.2_Intron	NM_052904	NP_443136	Q96NJ5	KLH32_HUMAN	kelch-like 32	308	Kelch 1.									ovary(3)|skin(1)	4		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		CAAGGAACTTCGGTACTTCAA	0.527000													25	52					0	0	0.00278032	0	0
ROS1	6098	broad.mit.edu	37	6	117645561	117645561	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:117645561C>T	uc003pxp.1	-	34	5774	c.5575G>A	c.(5575-5577)GAA>AAA	p.E1859K	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1859	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		AAACTTGTTTCTGGTATCCAA	0.294000			T	GOPC|ROS1	glioblastoma|NSCLC								12	26					0	0	0.00136819	0	0
PTPRK	5796	broad.mit.edu	37	6	128294914	128294914	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:128294914C>T	uc003qbk.2	-	28	4392	c.4025G>A	c.(4024-4026)CGA>CAA	p.R1342Q	PTPRK_uc003qbj.2_Missense_Mutation_p.R1343Q|PTPRK_uc010kfc.2_Missense_Mutation_p.R1349Q|PTPRK_uc011ebu.1_Missense_Mutation_p.R1365Q	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1342	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		AGGCACTTCTCGATGAGAAGC	0.478000													21	65					0	0	0.00152264	0	0
EPB41L2	2037	broad.mit.edu	37	6	131276354	131276354	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:131276354G>A	uc003qch.2	-	3	778	c.596C>T	c.(595-597)ACC>ATC	p.T199I	EPB41L2_uc003qcg.1_Missense_Mutation_p.T199I|EPB41L2_uc011eby.1_Missense_Mutation_p.T199I|EPB41L2_uc003qci.2_Missense_Mutation_p.T199I|EPB41L2_uc010kfk.2_Missense_Mutation_p.T199I|EPB41L2_uc010kfl.1_Missense_Mutation_p.T199I	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	199					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		CAGCTCATTGGTCTGCACTTC	0.433000													43	112					0	0	0.00361006	0	0
SLC35D3	340146	broad.mit.edu	37	6	137245608	137245608	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:137245608G>A	uc003qhe.2	+	2	1190	c.1025G>A	c.(1024-1026)GGA>GAA	p.G342E		NM_001008783	NP_001008783	Q5M8T2	S35D3_HUMAN	solute carrier family 35, member D3	342					carbohydrate transport	integral to membrane				ovary(1)|central_nervous_system(1)	2	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000136)|OV - Ovarian serous cystadenocarcinoma(155;0.00365)		GGGGAGGGAGGAAATGGCCGG	0.687000													6	18					0	0	0.00116845	0	0
HECA	51696	broad.mit.edu	37	6	139488217	139488217	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:139488217C>T	uc003qin.2	+	2	1353	c.1068C>T	c.(1066-1068)ATC>ATT	p.I356I		NM_016217	NP_057301	Q9UBI9	HDC_HUMAN	headcase	356					respiratory tube development						0				GBM - Glioblastoma multiforme(68;0.000252)|OV - Ovarian serous cystadenocarcinoma(155;0.000387)		TCACTCACATCCCCAGGCATA	0.607000													15	35					0	0	0.00400662	0	0
C6orf118	168090	broad.mit.edu	37	6	165715373	165715373	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:165715373G>A	uc003qum.3	-	2	474	c.438C>T	c.(436-438)TTC>TTT	p.F146F	C6orf118_uc011egi.1_RNA	NM_144980	NP_659417	Q5T5N4	CF118_HUMAN	hypothetical protein LOC168090	146											0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		CCACTGGAAGGAAATCCTCCT	0.627000													44	79					0	0	0.00361006	0	0
RPS6KA2	6196	broad.mit.edu	37	6	166831811	166831811	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:166831811C>T	uc003qvb.1	-	19	2059	c.1840G>A	c.(1840-1842)GGG>AGG	p.G614R	RPS6KA2_uc011ego.1_Missense_Mutation_p.G525R|RPS6KA2_uc010kkl.1_Missense_Mutation_p.G525R|RPS6KA2_uc003qvc.1_Missense_Mutation_p.G622R|RPS6KA2_uc003qvd.1_Missense_Mutation_p.G639R|RPS6KA2_uc010kkk.1_Missense_Mutation_p.G46R	NM_021135	NP_066958	Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	614	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		TCGTCTGGCCCATTTGCAAAA	0.443000													18	52					0	0	0.000958276	0	0
CARD11	84433	broad.mit.edu	37	7	2952944	2952944	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:2952944A>G	uc003smv.2	-	22	3400	c.2996T>C	c.(2995-2997)ATG>ACG	p.M999T		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	999	Guanylate kinase-like.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		GGTGAACTCCATGGCACCTCC	0.627000			Mis		DLBCL								24	107					0	0	0.00332997	0	0
ABCB5	340273	broad.mit.edu	37	7	20767987	20767987	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:20767987C>T	uc003suw.3	+	14	1987	c.1441C>T	c.(1441-1443)CAT>TAT	p.H481Y	ABCB5_uc010kuh.2_Missense_Mutation_p.H926Y|ABCB5_uc003sux.1_Missense_Mutation_p.H104Y	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	481	Helical; (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						TGCATTCAGCCATGCCTTTAT	0.403000													35	105					0	0	0.00375469	0	0
EVX1	2128	broad.mit.edu	37	7	27284840	27284840	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:27284840G>A	uc003szd.1	+	2	1087	c.601G>A	c.(601-603)GAA>AAA	p.E201K	EVX1_uc011jzn.1_Missense_Mutation_p.E19K|EVX1_uc010kuy.1_Silent_p.R182R	NM_001989	NP_001980	P49640	EVX1_HUMAN	even-skipped homeobox 1	201	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						GCTGGAGAAGGAATTCTACCG	0.647000													26	64					0	0	0.00395357	0	0
BMPER	168667	broad.mit.edu	37	7	34094894	34094894	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:34094894A>C	uc011kap.1	+	9	1020	c.906A>C	c.(904-906)AAA>AAC	p.K302N		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	302	VWFC 5.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						AAGTATGCAAATTTGGCAACA	0.493000													29	152					0	0	0.00209593	0	0
AOAH	313	broad.mit.edu	37	7	36570058	36570058	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:36570058G>A	uc003tfh.3	-	19	1889	c.1488C>T	c.(1486-1488)TTC>TTT	p.F496F	AOAH_uc010kxf.2_Silent_p.F496F|AOAH_uc011kba.1_Silent_p.F464F	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	496					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						AGAAAAGATTGAAGTTTGTAA	0.403000													19	41					0	0	0.00152264	0	0
AOAH	313	broad.mit.edu	37	7	36616204	36616204	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:36616204C>T	uc003tfh.3	-	13	1398	c.997G>A	c.(997-999)GAC>AAC	p.D333N	AOAH_uc010kxf.2_Missense_Mutation_p.D333N|AOAH_uc011kba.1_Missense_Mutation_p.D301N	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	333					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						TTCTGGTAGTCCCTGTGATTA	0.308000													32	161					0	0	0.00128727	0	0
HECW1	23072	broad.mit.edu	37	7	43484587	43484587	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:43484587G>A	uc003tid.1	+	11	2421	c.1816G>A	c.(1816-1818)GTG>ATG	p.V606M	HECW1_uc011kbi.1_Missense_Mutation_p.V606M	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	606					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						GGTGGACACGGTGGCCGCTGA	0.711000													9	14					0	0	0.000442599	0	0
ABCA13	154664	broad.mit.edu	37	7	48269475	48269475	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:48269475C>T	uc003toq.2	+	7	711	c.686C>T	c.(685-687)TCC>TTC	p.S229F	ABCA13_uc003top.2_3'UTR|ABCA13_uc010kyr.2_5'UTR	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	229					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CAAACTTTTTCCCAGGTTTCT	0.408000													48	176					0	0	0.00361006	0	0
ABCA13	154664	broad.mit.edu	37	7	48450124	48450124	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:48450124G>A	uc003toq.2	+	40	12103	c.12078G>A	c.(12076-12078)ACG>ACA	p.T4026T	ABCA13_uc010kys.1_Silent_p.T1100T|ABCA13_uc010kyt.1_RNA	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	4026	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CAGGTCGTACGATCATCTTCA	0.607000													22	88					0	0	0.000720815	0	0
POM121L12	285877	broad.mit.edu	37	7	53103666	53103666	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:53103666C>T	uc003tpz.2	+	1	318	c.302C>T	c.(301-303)GCC>GTC	p.A101V		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	101											0						AGGCGCCCTGCCCTTCCCGGG	0.726000													12	26					0	0	0.000978159	0	0
HGF	3082	broad.mit.edu	37	7	81392041	81392041	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:81392041C>T	uc003uhl.2	-	2	401	c.236G>A	c.(235-237)GGA>GAA	p.G79E	HGF_uc003uhm.2_Missense_Mutation_p.G79E|HGF_uc003uhn.1_Missense_Mutation_p.G79E|HGF_uc003uho.1_Missense_Mutation_p.G79E|HGF_uc003uhp.2_Missense_Mutation_p.G79E	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	79	PAN.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						GAATGGAAGTCCTTTATTCCT	0.323000													23	111					0	0	0.000878237	0	0
PTCD1	26024	broad.mit.edu	37	7	99032539	99032539	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:99032539G>A	uc003uqh.2	-	2	458	c.327C>T	c.(325-327)TTC>TTT	p.F109F	PTCD1_uc011kiw.1_Silent_p.F158F	NM_015545	NP_056360	O75127	PTCD1_HUMAN	pentatricopeptide repeat domain 1	109										ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			GCAGGTTATGGAACTGGGCTG	0.557000													97	112					0	0	0.00361006	0	0
ZAN	7455	broad.mit.edu	37	7	100369572	100369572	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:100369572C>T	uc003uwj.2	+	29	5519	c.5354C>T	c.(5353-5355)TCC>TTC	p.S1785F	ZAN_uc003uwk.2_Missense_Mutation_p.S1785F|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_Missense_Mutation_p.S362F|ZAN_uc011kke.1_5'Flank	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1785	Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CTGTGCCGCTCCCTGCAGGCC	0.647000													8	37					0	0	0.00307968	0	0
LRRC17	10234	broad.mit.edu	37	7	102579980	102579980	+	Missense_Mutation	SNP	T	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:102579980T>G	uc003vau.2	+	3	1265	c.876T>G	c.(874-876)CAT>CAG	p.H292Q	FBXL13_uc010liq.1_Intron|FBXL13_uc003vaq.2_Intron|FBXL13_uc010lir.1_Intron|FBXL13_uc003var.2_Intron|FBXL13_uc003vas.2_Intron|LRRC17_uc003vat.2_Missense_Mutation_p.H292Q	NM_001031692	NP_001026862	Q8N6Y2	LRC17_HUMAN	leucine rich repeat containing 17 isoform 1	292					bone marrow development|negative regulation of osteoclast differentiation|ossification	extracellular space				ovary(1)	1						AAGATGTTCATGAGCTGAAGA	0.403000													34	146					0	0	0.00428921	0	0
PNPLA8	50640	broad.mit.edu	37	7	108154961	108154961	+	Silent	SNP	T	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:108154961T>C	uc003vff.1	-	4	1382	c.975A>G	c.(973-975)GAA>GAG	p.E325E	PNPLA8_uc003vfg.1_RNA|PNPLA8_uc003vfh.1_Silent_p.E325E|PNPLA8_uc003vfi.1_Silent_p.E225E|PNPLA8_uc003vfj.1_Silent_p.E325E|PNPLA8_uc003vfk.1_Silent_p.E225E	NM_015723	NP_056538	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	325					fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(2)	2						TAGCAGGCTCTTCCTGTTCTT	0.438000													33	136					0	0	0.00375469	0	0
C7orf60	154743	broad.mit.edu	37	7	112462292	112462292	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:112462292A>G	uc003vgo.1	-	5	852	c.725T>C	c.(724-726)GTT>GCT	p.V242A	C7orf60_uc011kms.1_Missense_Mutation_p.V268A	NM_152556	NP_689769	Q1RMZ1	CG060_HUMAN	hypothetical protein LOC154743	242										ovary(2)|skin(1)	3						GAGAGAGAAAACAACCACATG	0.408000													12	18					0	0	0.000978159	0	0
MET	4233	broad.mit.edu	37	7	116409818	116409818	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:116409818G>A	uc003vij.2	+	12	2890	c.2703G>A	c.(2701-2703)CTG>CTA	p.L901L	MET_uc010lkh.2_Silent_p.L919L|MET_uc011knj.1_Silent_p.L471L	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	901	Extracellular (Potential).				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			ATGACCTGCTGAAATTGAACA	0.383000			Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				34	56					0	0	0.000953801	0	0
RNF133	168433	broad.mit.edu	37	7	122338165	122338165	+	Missense_Mutation	SNP	G	A	A	rs113296018	byFrequency	TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:122338165G>A	uc003vkj.1	-	1	1044	c.808C>T	c.(808-810)CGT>TGT	p.R270C	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	270	RING-type; atypical.					endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			skin(1)	1						GTCAGAATACGAACTATGTCA	0.388000													67	82					0	0	0.00361006	0	0
FSCN3	29999	broad.mit.edu	37	7	127235455	127235455	+	Missense_Mutation	SNP	G	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:127235455G>C	uc003vmd.1	+	2	458	c.239G>C	c.(238-240)GGC>GCC	p.G80A	FSCN3_uc003vmc.1_Missense_Mutation_p.G35A|FSCN3_uc011kog.1_RNA|FSCN3_uc011koh.1_5'UTR|FSCN3_uc010llc.1_Missense_Mutation_p.G80A	NM_020369	NP_065102	Q9NQT6	FSCN3_HUMAN	fascin 3	80						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			ovary(1)	1						GAGTGTGATGGCACCGTGTGT	0.577000													19	71					0	0	0.00152264	0	0
METTL2B	55798	broad.mit.edu	37	7	128119282	128119282	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:128119282G>A	uc003vnf.2	+	3	310	c.273G>A	c.(271-273)AAG>AAA	p.K91K	METTL2B_uc003vng.2_Silent_p.K26K|METTL2B_uc011kop.1_5'UTR	NM_018396	NP_060866	Q6P1Q9	MTL2B_HUMAN	methyltransferase like 2B	91							methyltransferase activity			skin(1)	1						GGTTTTTCAAGGATAGACATT	0.348000													5	47					0	0	0.00307968	0	0
CALD1	800	broad.mit.edu	37	7	134625906	134625906	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:134625906C>T	uc003vrz.2	+	7	1909	c.1450C>T	c.(1450-1452)CGA>TGA	p.R484*	CALD1_uc003vry.2_Nonsense_Mutation_p.R229*|CALD1_uc003vsa.2_Nonsense_Mutation_p.R255*|CALD1_uc003vsb.2_Nonsense_Mutation_p.R229*|CALD1_uc010lmm.2_Nonsense_Mutation_p.R255*|CALD1_uc011kpt.1_Nonsense_Mutation_p.R3*|CALD1_uc003vsc.2_Nonsense_Mutation_p.R249*|CALD1_uc003vsd.2_Nonsense_Mutation_p.R223*|CALD1_uc011kpu.1_Nonsense_Mutation_p.R234*|CALD1_uc011kpv.1_Nonsense_Mutation_p.R93*|CALD1_uc003vse.2_Nonsense_Mutation_p.R348*	NM_033138	NP_149129	Q05682	CALD1_HUMAN	caldesmon 1 isoform 1	484					cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding				0						CTTCATGGATCGAAAGAAGGG	0.358000													20	46					0	0	0.00152264	0	0
AKR1D1	6718	broad.mit.edu	37	7	137792257	137792257	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:137792257C>T	uc003vtz.2	+	7	855	c.786C>T	c.(784-786)TTC>TTT	p.F262F	AKR1D1_uc011kqe.1_Silent_p.F262F|AKR1D1_uc011kqf.1_Silent_p.F221F|AKR1D1_uc010lmy.1_RNA	NM_005989	NP_005980	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	262					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			skin(1)	1						TTTTGCGTTTCAACATCCAGC	0.378000													20	78					0	0	0.00229938	0	0
DENND2A	27147	broad.mit.edu	37	7	140301538	140301538	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:140301538C>T	uc010lnj.2	-	1	805	c.660G>A	c.(658-660)TCG>TCA	p.S220S	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Silent_p.S220S|DENND2A_uc003vvw.2_Silent_p.S220S|DENND2A_uc003vvx.2_Silent_p.S220S	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	220										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					CTTCCAGGTCCGAGGGGTGGA	0.637000													69	78					0	0	0.00361006	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				45	45					0	0	0.00361006	0	0
CLEC5A	23601	broad.mit.edu	37	7	141635657	141635657	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:141635657C>T	uc003vwv.1	-	5	499	c.302G>A	c.(301-303)GGA>GAA	p.G101E	CLEC5A_uc011krm.1_Missense_Mutation_p.G78E|CLEC5A_uc003vww.1_Missense_Mutation_p.G101E|CLEC5A_uc010lnq.1_Missense_Mutation_p.G78E|CLEC5A_uc010lnr.1_Intron	NM_013252	NP_037384	Q9NY25	CLC5A_HUMAN	C-type lectin, superfamily member 5	101	C-type lectin.|Extracellular (Potential).				anti-apoptosis|cellular defense response|innate immune response|interspecies interaction between organisms|osteoblast development	cell surface|integral to plasma membrane	sugar binding|viral receptor activity				0	Melanoma(164;0.0171)					GGATCCTTTTCCTTTGCAAAA	0.443000													48	76					0	0	0.00361006	0	0
CLEC5A	23601	broad.mit.edu	37	7	141643748	141643748	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:141643748C>T	uc003vwv.1	-	4	353	c.156G>A	c.(154-156)GGG>GGA	p.G52G	CLEC5A_uc011krm.1_Intron|CLEC5A_uc003vww.1_Silent_p.G52G|CLEC5A_uc010lnq.1_Intron|CLEC5A_uc010lnr.1_Intron	NM_013252	NP_037384	Q9NY25	CLC5A_HUMAN	C-type lectin, superfamily member 5	52	Extracellular (Potential).				anti-apoptosis|cellular defense response|innate immune response|interspecies interaction between organisms|osteoblast development	cell surface|integral to plasma membrane	sugar binding|viral receptor activity				0	Melanoma(164;0.0171)					GGGAACTGCTCCCAAAAATCT	0.438000													72	92					0	0	0.00361006	0	0
MGAM	8972	broad.mit.edu	37	7	141764249	141764249	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:141764249C>T	uc003vwy.2	+	37	4465	c.4411C>T	c.(4411-4413)CCA>TCA	p.P1471S		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1471	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GCAGATCCTCCCAGACGGCTC	0.582000													10	6					0	0	0.000442599	0	0
EPHB6	2051	broad.mit.edu	37	7	142564278	142564278	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:142564278C>T	uc011kst.1	+	10	2289	c.1502C>T	c.(1501-1503)TCC>TTC	p.S501F	EPHB6_uc011ksu.1_Missense_Mutation_p.S501F|EPHB6_uc003wbs.2_Missense_Mutation_p.S209F|EPHB6_uc003wbt.2_5'UTR|EPHB6_uc003wbu.2_Missense_Mutation_p.S209F|EPHB6_uc003wbv.2_5'Flank	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	501	Fibronectin type-III 2.|Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					AGCCGGGCATCCAACAGCATC	0.587000													30	25					0	0	0.00178596	0	0
SSPO	23145	broad.mit.edu	37	7	149480322	149480322	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:149480322C>T	uc010lpk.2	+	16	2204	c.2204C>T	c.(2203-2205)CCC>CTC	p.P735L	SSPO_uc010lpl.1_Missense_Mutation_p.P70L	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	735	VWFD 2.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGAAGATGCCCCTCTGAGGAC	0.617000													5	48					0	0	0.00307968	0	0
MLL3	58508	broad.mit.edu	37	7	151960106	151960106	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:151960106A>G	uc003wla.2	-	9	1513	c.1294T>C	c.(1294-1296)TGC>CGC	p.C432R		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	432	PHD-type 2.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CTTACTTTGCATTTCCAGCCA	0.338000			N		medulloblastoma								43	49					0	0	0.00170553	0	0
DPP6	1804	broad.mit.edu	37	7	154585800	154585800	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:154585800T>C	uc003wlk.2	+	11	1277	c.1148T>C	c.(1147-1149)ATC>ACC	p.I383T	DPP6_uc003wli.2_Missense_Mutation_p.I319T|DPP6_uc003wlm.2_Missense_Mutation_p.I321T|DPP6_uc011kvq.1_Missense_Mutation_p.I276T	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	383	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GAGTACTACATCACCATGGTG	0.652000													19	18					0	0	0.00152264	0	0
RP1L1	94137	broad.mit.edu	37	8	10467773	10467773	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:10467773C>T	uc003wtc.2	-	4	4064	c.3835G>A	c.(3835-3837)GAC>AAC	p.D1279N		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1279					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TCCTCACTGTCTCTTTCTGCT	0.483000													43	108					0	0	0.00361006	0	0
MIR598	693183	broad.mit.edu	37	8	10892744	10892744	+	RNA	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:10892744G>A	hsa-mir-598|MI0003610	-			c.69G>A			XKR6_uc003wtk.1_Intron																	0						cgatgacaacgatgacgTAGC	0.299000													21	25					0	0	0.00121646	0	0
BLK	640	broad.mit.edu	37	8	11412309	11412309	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:11412309A>G	uc003wty.2	+	7	1111	c.530A>G	c.(529-531)TAT>TGT	p.Y177C	BLK_uc003wtz.2_Missense_Mutation_p.Y106C	NM_001715	NP_001706	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	177	SH2.				intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			large_intestine(1)|stomach(1)|ovary(1)	3			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		ATCAAGCACTATAAGATCCGC	0.567000													20	43					0	0	0.00278032	0	0
ADAM7	8756	broad.mit.edu	37	8	24326320	24326320	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:24326320C>T	uc003xeb.2	+	7	733	c.620C>T	c.(619-621)GCT>GTT	p.A207V		NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	207	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		TTCATTGTTGCTGATGATACT	0.318000													19	49					0	0	0.00188189	0	0
ELP3	55140	broad.mit.edu	37	8	27957418	27957418	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:27957418C>T	uc003xgo.3	+	3	341	c.193C>T	c.(193-195)CCT>TCT	p.P65S	ELP3_uc003xgn.3_Missense_Mutation_p.P50S|ELP3_uc011laq.1_5'UTR|ELP3_uc011lar.1_Intron|ELP3_uc011las.1_5'UTR|ELP3_uc011lat.1_Intron	NM_018091	NP_060561	Q9H9T3	ELP3_HUMAN	elongation protein 3 homolog	65					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	histone acetyltransferase activity|iron-sulfur cluster binding|metal ion binding|phosphorylase kinase regulator activity|protein binding				0		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.151)|Colorectal(74;0.183)		TGCTGCCGTCCCTCCTCAGTA	0.502000													22	56					0	0	0.00332997	0	0
INTS9	55756	broad.mit.edu	37	8	28627437	28627437	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:28627437G>A	uc003xha.2	-	16	2068	c.1769C>T	c.(1768-1770)CCT>CTT	p.P590L	INTS9_uc011lav.1_Missense_Mutation_p.P566L|INTS9_uc011law.1_Missense_Mutation_p.P569L|INTS9_uc011lax.1_Missense_Mutation_p.P483L|INTS9_uc010lvc.2_RNA	NM_018250	NP_060720	Q9NV88	INT9_HUMAN	integrator complex subunit 9 isoform 1	590					snRNA processing	integrator complex	protein binding			central_nervous_system(1)|pancreas(1)	2		Ovarian(32;0.0439)		KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.152)		CTGCTCCACAGGGATGGAACC	0.607000											OREG0018682	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	54					0	0	0.00395357	0	0
HMBOX1	79618	broad.mit.edu	37	8	28876343	28876343	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:28876343C>T	uc003xhd.3	+	6	1106	c.764C>T	c.(763-765)CCC>CTC	p.P255L	HMBOX1_uc010lvd.2_Missense_Mutation_p.P255L|HMBOX1_uc003xhc.3_Missense_Mutation_p.P255L|HMBOX1_uc010lve.2_RNA|HMBOX1_uc003xhe.2_Missense_Mutation_p.P255L|HMBOX1_uc011lay.1_Missense_Mutation_p.P255L|HMBOX1_uc003xhf.2_Missense_Mutation_p.P243L|HMBOX1_uc003xhg.2_Missense_Mutation_p.P243L	NM_001135726	NP_001129198	Q6NT76	HMBX1_HUMAN	homeobox containing 1	255					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Ovarian(32;0.0192)		KIRC - Kidney renal clear cell carcinoma(542;0.135)|Kidney(114;0.161)		CAAACGCCTCCCCCAGTCTCT	0.488000													25	51					0	0	0.000720815	0	0
ADAM9	8754	broad.mit.edu	37	8	38865485	38865485	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:38865485A>T	uc003xmr.2	+	2	256	c.178A>T	c.(178-180)AGG>TGG	p.R60W	ADAM9_uc011lcf.1_RNA|ADAM9_uc011lcg.1_RNA|ADAM9_uc010lwr.2_RNA|ADAM9_uc003xmo.1_Missense_Mutation_p.R60W|ADAM9_uc003xmp.2_Missense_Mutation_p.R60W	NM_003816	NP_003807	Q13443	ADAM9_HUMAN	ADAM metallopeptidase domain 9 isoform 1	60	Extracellular (Potential).			Missing (in Ref. 2; no nucleotide entry).	activation of MAPKK activity|cell-cell adhesion mediated by integrin|cell-matrix adhesion|keratinocyte differentiation|monocyte activation|PMA-inducible membrane protein ectodomain proteolysis|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell adhesion mediated by integrin|positive regulation of keratinocyte migration|positive regulation of macrophage fusion|positive regulation of membrane protein ectodomain proteolysis|positive regulation of protein secretion|response to calcium ion|response to glucocorticoid stimulus|response to hydrogen peroxide|response to manganese ion|response to tumor necrosis factor|transforming growth factor beta receptor signaling pathway	extracellular space|extracellular space|integral to membrane|intrinsic to external side of plasma membrane	collagen binding|integrin binding|laminin binding|metalloendopeptidase activity|protein kinase C binding|SH3 domain binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;2.74e-07)			AGAAGCCCCTAGGCCCTATTC	0.328000													14	45					0	0	0.00244969	0	0
ADAM32	203102	broad.mit.edu	37	8	39114851	39114851	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:39114851C>T	uc003xmt.3	+	19	2396	c.2151C>T	c.(2149-2151)TTC>TTT	p.F717F	ADAM32_uc011lch.1_Silent_p.F618F|ADAM32_uc003xmu.3_Silent_p.F611F|ADAM32_uc003xmv.2_Silent_p.F141F	NM_145004	NP_659441	Q8TC27	ADA32_HUMAN	a disintegrin and metalloprotease domain 32	717	Cytoplasmic (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			AAGAGGAATTCCCAAGTAGCG	0.368000													40	92					0	0	0.00361006	0	0
ADAM2	2515	broad.mit.edu	37	8	39624428	39624428	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:39624428C>T	uc003xnj.2	-	14	1521	c.1446G>A	c.(1444-1446)TGG>TGA	p.W482*	ADAM2_uc003xnk.2_Nonsense_Mutation_p.W463*|ADAM2_uc011lck.1_Nonsense_Mutation_p.W482*|ADAM2_uc003xnl.2_Nonsense_Mutation_p.W356*	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	482	Extracellular (Potential).|Cys-rich.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		CTATACAGATCCATTGATTCA	0.388000													32	26					0	0	0.00283554	0	0
MYST3	7994	broad.mit.edu	37	8	41834788	41834788	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:41834788T>A	uc010lxb.2	-	8	1645	c.1101A>T	c.(1099-1101)AAA>AAT	p.K367N	MYST3_uc010lxc.2_Missense_Mutation_p.K367N|MYST3_uc003xon.3_Missense_Mutation_p.K367N|MYST3_uc010lxd.2_Missense_Mutation_p.K367N	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	367	Interaction with RUNX1-1.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			AAAGAGTGATTTTTCGTTTCC	0.413000													20	61					0	0	0.00188189	0	0
PRKDC	5591	broad.mit.edu	37	8	48842431	48842431	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:48842431C>T	uc003xqi.2	-	18	2091	c.2034G>A	c.(2032-2034)AAG>AAA	p.K678K	PRKDC_uc003xqj.2_Silent_p.K678K|PRKDC_uc011ldh.1_Silent_p.K678K	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	678					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				ATTTTATTTTCTTGGCATTTC	0.318000								NHEJ					10	29					0	0	0.000978159	0	0
PREX2	80243	broad.mit.edu	37	8	69020350	69020350	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:69020350C>T	uc003xxv.1	+	24	2749	c.2722C>T	c.(2722-2724)CGT>TGT	p.R908C	PREX2_uc011lez.1_Missense_Mutation_p.R843C	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	908					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GCAGTTTTCTCGTGTACTGAA	0.393000													7	26					0	0	0.00198382	0	0
PREX2	80243	broad.mit.edu	37	8	69129915	69129915	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:69129915C>T	uc003xxv.1	+	38	4696	c.4669C>T	c.(4669-4671)CGT>TGT	p.R1557C		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1557					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						ACTGCCACCTCGTTACATCAT	0.552000													9	17					0	0	0.000673444	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70667861	70667861	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:70667861G>A	uc003xyl.2	-	4	1763	c.1056C>T	c.(1054-1056)CTC>CTT	p.L352L	SLCO5A1_uc010lzb.2_Silent_p.L352L|SLCO5A1_uc011lfa.1_Intron|SLCO5A1_uc003xyk.2_Silent_p.L352L|SLCO5A1_uc010lzc.2_Silent_p.L352L	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	352	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			TGGCACAAAGGAGGAATCCAC	0.343000													13	24					0	0	0.00136819	0	0
CDH17	1015	broad.mit.edu	37	8	95178002	95178002	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:95178002C>T	uc003ygh.2	-	10	1394	c.1269G>A	c.(1267-1269)GAG>GAA	p.E423E	CDH17_uc011lgo.1_Silent_p.E209E|CDH17_uc011lgp.1_Silent_p.E423E	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	423	Extracellular (Potential).|Cadherin 4.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			TGTCAGACACCTCTATCGTTA	0.398000													15	53					0	0	0.000566183	0	0
PLEKHF2	79666	broad.mit.edu	37	8	96166422	96166422	+	Silent	SNP	C	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:96166422C>A	uc003yhn.1	+	2	397	c.150C>A	c.(148-150)CCC>CCA	p.P50P		NM_024613	NP_078889	Q9H8W4	PKHF2_HUMAN	phafin 2	50	PH.					transport vesicle	metal ion binding|protein binding			ovary(2)	2	Breast(36;3.18e-05)					GGAAAAAGCCCAAAGCAAGGC	0.358000													14	555					0.00244969	0.00842614	0.00244969	1	0
RIMS2	9699	broad.mit.edu	37	8	104897590	104897590	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:104897590G>A	uc003yls.2	+	2	338	c.97G>A	c.(97-99)GAA>AAA	p.E33K	RIMS2_uc003ylp.2_Missense_Mutation_p.E255K|RIMS2_uc003ylw.2_Missense_Mutation_p.E63K|RIMS2_uc003ylq.2_Missense_Mutation_p.E63K|RIMS2_uc003ylr.2_Missense_Mutation_p.E63K	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	286					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AGAAAGAGAGGAATATTCACA	0.413000										HNSCC(12;0.0054)			12	23					0	0	0.00185496	0	0
TRHR	7201	broad.mit.edu	37	8	110131314	110131314	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:110131314C>T	uc003ymz.3	+	2	843	c.827C>T	c.(826-828)GCC>GTC	p.A276V		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	276	Helical; Name=6; (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			ATTCTGTTTGCCCTTTTATGG	0.403000													80	175					0	0	0.00361006	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110431368	110431368	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:110431368G>A	uc003yne.2	+	22	2507	c.2403G>A	c.(2401-2403)ACG>ACA	p.T801T		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	801	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCGTAAGAACGAAATACACTG	0.373000										HNSCC(38;0.096)			14	35					0	0	0.000566183	0	0
CSMD3	114788	broad.mit.edu	37	8	113529291	113529291	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:113529291G>A	uc003ynu.2	-	28	4887	c.4728C>T	c.(4726-4728)TTC>TTT	p.F1576F	CSMD3_uc003yns.2_Silent_p.F848F|CSMD3_uc003ynt.2_Silent_p.F1536F|CSMD3_uc011lhx.1_Silent_p.F1472F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1576	Extracellular (Potential).|Sushi 8.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGGGCTGCCAGAAGTACCGAT	0.368000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			26	49					0	0	0.00209593	0	0
LRRC6	23639	broad.mit.edu	37	8	133584601	133584601	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:133584601C>T	uc003ytk.2	-	12	1428	c.1354G>A	c.(1354-1356)GAA>AAA	p.E452K	LRRC6_uc003ytl.2_RNA	NM_012472	NP_036604	Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	452						cytoplasm				ovary(1)|kidney(1)	2	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GTTGGGTCTTCCTCACTTGGT	0.478000													39	108					0	0	0.00148497	0	0
FAM135B	51059	broad.mit.edu	37	8	139164294	139164294	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:139164294G>A	uc003yuy.2	-	13	2595	c.2424C>T	c.(2422-2424)TCC>TCT	p.S808S	FAM135B_uc003yux.2_Silent_p.S709S|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Silent_p.S370S|FAM135B_uc003yvb.2_Silent_p.S370S	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	808										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AAGATCCTGGGGAACCTTGGC	0.527000										HNSCC(54;0.14)			26	36					0	0	0.00106085	0	0
DENND3	22898	broad.mit.edu	37	8	142204174	142204174	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:142204174G>A	uc003yvy.2	+	23	3717	c.3439G>A	c.(3439-3441)GGG>AGG	p.G1147R	DENND3_uc010mep.2_Missense_Mutation_p.G1108R|DENND3_uc003ywa.1_3'UTR|DENND3_uc003ywb.2_Missense_Mutation_p.G197R	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	1147										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			AACACCCAAGGGGAAAATCTA	0.627000													21	63					0	0	0.00332997	0	0
EPPK1	83481	broad.mit.edu	37	8	144940463	144940463	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:144940463G>A	uc003zaa.1	-	2	14982	c.14969C>T	c.(14968-14970)TCC>TTC	p.S4990F		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	4990	Plectin 63.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CTGGAAGAGGGAGATCTGCTG	0.706000													16	245					0	0	0.000566183	0	0
PLEC	5339	broad.mit.edu	37	8	144995049	144995049	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:144995049C>T	uc003zaf.1	-	32	9521	c.9351G>A	c.(9349-9351)CTG>CTA	p.L3117L	PLEC_uc003zab.1_Silent_p.L2980L|PLEC_uc003zac.1_Silent_p.L2984L|PLEC_uc003zad.2_Silent_p.L2980L|PLEC_uc003zae.1_Silent_p.L2948L|PLEC_uc003zag.1_Silent_p.L2958L|PLEC_uc003zah.2_Silent_p.L2966L|PLEC_uc003zaj.2_Silent_p.L3007L	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3117	Plectin 6.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CGGCTGGCACCAGGCTGCGCA	0.642000													11	14					0	0	0.000978159	0	0
NFKBIL2	4796	broad.mit.edu	37	8	145661974	145661975	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:145661974_145661975CC>TT	uc011llg.1	-	16	1995_1996	c.1980_1981GG>AA	c.(1978-1983)ATGGAG>ATAAAG	p.660_661ME>IK	uc011llh.1_Intron	NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	660_661					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			AGCAGCATCTCCATGGCCCTGG	0.673000													10	39					0	0	6.4e-05	0	0
ZNF16	7564	broad.mit.edu	37	8	146157540	146157540	+	Silent	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:146157540A>G	uc003zet.2	-	4	820	c.633T>C	c.(631-633)TGT>TGC	p.C211C	ZNF16_uc003zeu.2_Silent_p.C211C	NM_001029976	NP_001025147	P17020	ZNF16_HUMAN	zinc finger protein 16	211	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		CACACTCATTACATATGAGTG	0.483000													3	134					0	0	6.4e-05	0	0
CDC37L1	55664	broad.mit.edu	37	9	4697103	4697103	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:4697103G>A	uc003zio.2	+	4	726	c.516G>A	c.(514-516)TTG>TTA	p.L172L		NM_017913	NP_060383	Q7L3B6	CD37L_HUMAN	cell division cycle 37 homolog (S.	172	Self-association and interaction with Hsp90.					cytoplasm					0	all_hematologic(13;0.137)	Breast(48;0.238)		GBM - Glioblastoma multiforme(50;0.0318)		CAGGTATGTTGAGTCGATGGG	0.338000													5	45					0	0	0.00198382	0	0
CDC37L1	55664	broad.mit.edu	37	9	4697137	4697137	+	Missense_Mutation	SNP	G	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:4697137G>C	uc003zio.2	+	4	760	c.550G>C	c.(550-552)GAC>CAC	p.D184H		NM_017913	NP_060383	Q7L3B6	CD37L_HUMAN	cell division cycle 37 homolog (S.	184	Self-association and interaction with Hsp90.					cytoplasm					0	all_hematologic(13;0.137)	Breast(48;0.238)		GBM - Glioblastoma multiforme(50;0.0318)		ATTTTTGTCTGACCATCCATA	0.348000													9	55					0	0	0.000978159	0	0
INSL6	11172	broad.mit.edu	37	9	5164194	5164194	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:5164194C>T	uc003zix.2	-	2	377	c.361G>A	c.(361-363)GGA>AGA	p.G121R		NM_007179	NP_009110	Q9Y581	INSL6_HUMAN	insulin-like 6 precursor	121						extracellular region	hormone activity				0	all_hematologic(13;0.137)	Breast(48;0.147)|Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0128)|Lung(218;0.145)		GGTGAATATCCCTTTTTATCC	0.348000													78	29					0	0	0.00361006	0	0
CER1	9350	broad.mit.edu	37	9	14722193	14722193	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:14722193C>T	uc003zlj.2	-	1	523	c.478G>A	c.(478-480)GAG>AAG	p.E160K		NM_005454	NP_005445	O95813	CER1_HUMAN	cerberus 1 precursor	160					BMP signaling pathway	extracellular space	cytokine activity				0				GBM - Glioblastoma multiforme(50;3.16e-06)		CTGCAGGTCTCCCAATGTACT	0.522000													24	23					0	0	0.00395357	0	0
FREM1	158326	broad.mit.edu	37	9	14804986	14804986	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:14804986C>T	uc003zlm.2	-	19	4029	c.3439G>A	c.(3439-3441)GAA>AAA	p.E1147K	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1147	CSPG 8.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		TCAGGAGCTTCATCATTTGTG	0.363000													25	31					0	0	0.00395357	0	0
C9orf131	138724	broad.mit.edu	37	9	35045666	35045666	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:35045666G>A	uc003zvw.2	+	2	3069	c.3040G>A	c.(3040-3042)GGT>AGT	p.G1014S	C9orf131_uc003zvu.2_Missense_Mutation_p.G966S|C9orf131_uc003zvv.2_Missense_Mutation_p.G941S|C9orf131_uc003zvx.2_Missense_Mutation_p.G979S	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	1014											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			CAAAGCTTCGGGTCCCCAGGA	0.577000													19	26					0	0	0.00074312	0	0
NPR2	4882	broad.mit.edu	37	9	35800423	35800423	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:35800423C>T	uc003zyd.2	+	5	1161	c.1161C>T	c.(1159-1161)GAC>GAT	p.D387D	NPR2_uc010mlb.2_Silent_p.D387D	NM_003995	NP_003986	P20594	ANPRB_HUMAN	natriuretic peptide receptor B precursor	387	Extracellular (Potential).				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			ovary(2)|stomach(1)	3	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	AGAACAATGACCGAGAGACTG	0.527000													14	89					0	0	0.00316338	0	0
RECK	8434	broad.mit.edu	37	9	36087828	36087828	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:36087828C>T	uc003zyv.2	+	9	861	c.775C>T	c.(775-777)CCT>TCT	p.P259S	RECK_uc003zyw.2_Missense_Mutation_p.P131S|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	259	Knot 4.|5 X Knot repeats.					anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			GCCTCAAGATCCTCTTTGGCA	0.483000													20	66					0	0	0.00152264	0	0
TJP2	9414	broad.mit.edu	37	9	71849418	71849418	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:71849418C>T	uc004ahe.2	+	12	1935	c.1735C>T	c.(1735-1737)CCT>TCT	p.P579S	TJP2_uc011lrs.1_Missense_Mutation_p.P556S|TJP2_uc011lrt.1_Missense_Mutation_p.P556S|TJP2_uc004ahd.2_Missense_Mutation_p.P579S|TJP2_uc004ahf.2_Missense_Mutation_p.P579S|TJP2_uc011lru.1_Missense_Mutation_p.P583S|TJP2_uc011lrv.1_Missense_Mutation_p.P601S	NM_004817	NP_004808	Q9UDY2	ZO2_HUMAN	tight junction protein 2 (zona occludens 2)	579	PDZ 3.				cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding				0						GTTAGAAATCCCTAAAGGTGA	0.413000													26	35					0	0	0.00178596	0	0
PRUNE2	158471	broad.mit.edu	37	9	79325833	79325833	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:79325833C>G	uc010mpk.2	-	8	1481	c.1357G>C	c.(1357-1359)GGA>CGA	p.G453R		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	453					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						GCACCTTCTCCCACGGGGCTG	0.597000													13	10					0	0	0.00316338	0	0
CTSL1	1514	broad.mit.edu	37	9	90345972	90345972	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:90345972C>T	uc004aph.2	+	8	1302	c.952C>T	c.(952-954)CGG>TGG	p.R318W	CTSL1_uc004api.2_Missense_Mutation_p.R318W|CTSL1_uc004apj.2_Missense_Mutation_p.R263W|CTSL1_uc010mqh.2_Missense_Mutation_p.R136W|CTSL1_uc004apk.2_Missense_Mutation_p.R318W|CTSL1_uc004apl.2_Missense_Mutation_p.R318W	NM_001912	NP_001903	P07711	CATL1_HUMAN	cathepsin L1 preproprotein	318					macrophage apoptosis|proteolysis	extracellular region|lysosome|nucleus	cysteine-type endopeptidase activity|histone binding			ovary(3)	3					Glucagon recombinant(DB00040)	GGCCAAAGACCGGAGAAACCA	0.522000													9	15					0	0	0.000673444	0	0
C9orf89	84270	broad.mit.edu	37	9	95872947	95872948	+	Missense_Mutation	DNP	CC	GT	GT			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:95872947_95872948CC>GT	uc004atd.2	+	3	426_427	c.248_249CC>GT	c.(247-249)GCC>GGT	p.A83G	C9orf89_uc004ate.2_RNA|C9orf89_uc004atf.2_RNA	NM_032310	NP_115686	Q96LW7	BINCA_HUMAN	chromosome 9 open reading frame 89	83	CARD.				negative regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|nucleus	CARD domain binding				0						TTCTACCGAGCCCTGTATATCC	0.510000													23	36					0	0	6.4e-05	0	0
LPAR1	1902	broad.mit.edu	37	9	113703966	113703966	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:113703966G>A	uc004bfa.2	-	4	783	c.528C>T	c.(526-528)ATC>ATT	p.I176I	LPAR1_uc011lwm.1_Silent_p.I177I|LPAR1_uc004bfb.2_Silent_p.I176I|LPAR1_uc004bfc.2_Silent_p.I176I|LPAR1_uc011lwn.1_Silent_p.I158I|LPAR1_uc011lwo.1_Silent_p.I177I|LPAR1_uc010mub.2_Silent_p.I176I	NM_057159	NP_476500	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	176	Helical; Name=4; (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				ovary(2)	2						CACCCATAACGATGGCCATAG	0.498000													26	32					0	0	0.000720815	0	0
C9orf80	58493	broad.mit.edu	37	9	115456459	115456459	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:115456459C>G	uc004bgg.2	-	3	257	c.80G>C	c.(79-81)AGA>ACA	p.R27T	C9orf80_uc010muk.2_RNA	NM_021218	NP_067041	Q9NRY2	SOSSC_HUMAN	SOSSC protein	27					DNA repair|response to ionizing radiation	SOSS complex	protein binding				0						AAGTAGTTTTCTTTTCTCTTT	0.313000													27	63					0	0	0.00283554	0	0
FKBP15	23307	broad.mit.edu	37	9	115930838	115930838	+	Splice_Site	SNP	T	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:115930838T>C	uc004bgs.2	-	27	3604	c.3486_splice	c.e27-1	p.S1162_splice	FKBP15_uc004bgr.2_Splice_Site_p.S599_splice|FKBP15_uc011lxc.1_Splice_Site_p.S743_splice	NM_015258	NP_056073	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa						endocytosis|protein folding	axon|early endosome	actin binding			ovary(3)	3						CCAGAGAGACTGAAGGAAAAT	0.498000													20	36					0	0	0.00229938	0	0
ASTN2	23245	broad.mit.edu	37	9	119188211	119188211	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:119188211G>A	uc004bjs.1	-	23	4040	c.3939C>T	c.(3937-3939)ATC>ATT	p.I1313I	ASTN2_uc004bjr.1_Silent_p.I1309I|ASTN2_uc004bjt.1_Silent_p.I1262I|ASTN2_uc004bjp.1_Silent_p.I406I|ASTN2_uc004bjq.1_Silent_p.I365I|ASTN2_uc011lxr.1_Silent_p.I365I|ASTN2_uc011lxs.1_Silent_p.I365I|ASTN2_uc011lxt.1_Silent_p.I365I|ASTN2_uc004bjo.1_Silent_p.I94I	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	1313	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						TGTCCTTGAGGATGCTATACC	0.592000													11	16					0	0	0.000978159	0	0
POMT1	10585	broad.mit.edu	37	9	134382804	134382804	+	Silent	SNP	C	T	T	rs138064523	byFrequency	TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:134382804C>T	uc004cav.2	+	5	532	c.330C>T	c.(328-330)CTC>CTT	p.L110L	POMT1_uc011mci.1_Silent_p.L110L|POMT1_uc004cax.2_Silent_p.L110L|POMT1_uc011mcj.1_Intron|POMT1_uc004cau.2_Silent_p.L110L|POMT1_uc004caw.2_Silent_p.L56L|POMT1_uc011mck.1_5'UTR|POMT1_uc011mcl.1_Intron|POMT1_uc011mcm.1_Silent_p.L80L|POMT1_uc011mcn.1_5'Flank	NM_007171	NP_009102	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1 isoform a	110	Helical; (Potential).				multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			upper_aerodigestive_tract(1)	1		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		TGCCAGCACTCGCGGGGGCCT	0.562000													33	60					0	0	0.00283554	0	0
GTF3C4	9329	broad.mit.edu	37	9	135553441	135553441	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:135553441C>T	uc010mzv.2	+	2	693	c.435C>T	c.(433-435)TTC>TTT	p.F145F	GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	145					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		GTCAGACTTTCATGTTGGATA	0.483000													25	73					0	0	0.000720815	0	0
NLGN4X	57502	broad.mit.edu	37	X	6069279	6069279	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:6069279G>A	uc010ndh.2	-	2	730	c.229C>T	c.(229-231)CCC>TCC	p.P77S	NLGN4X_uc004crp.2_Missense_Mutation_p.P77S|NLGN4X_uc004crq.2_Missense_Mutation_p.P77S|NLGN4X_uc010ndi.2_Missense_Mutation_p.P77S|NLGN4X_uc004crr.2_Missense_Mutation_p.P77S|NLGN4X_uc010ndj.2_Missense_Mutation_p.P77S	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	77	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						GAGGCATAGGGGACCCCTAAG	0.542000													18	45					0	0	0.00074312	0	0
SH3KBP1	30011	broad.mit.edu	37	X	19568112	19568112	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:19568112G>A	uc004czm.2	-	14	1790	c.1474C>T	c.(1474-1476)CCG>TCG	p.P492S	SH3KBP1_uc011mje.1_Missense_Mutation_p.P231S|SH3KBP1_uc011mjf.1_Missense_Mutation_p.P254S|SH3KBP1_uc004czl.2_Missense_Mutation_p.P455S|SH3KBP1_uc010nfm.2_5'UTR	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a	492					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0						GACTGGGACGGAGGCCGCCTC	0.463000													26	165					0	0	0.00178596	0	0
SMS	6611	broad.mit.edu	37	X	21997082	21997082	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:21997082C>T	uc004dag.2	+	7	849	c.748C>T	c.(748-750)CAG>TAG	p.Q250*	SMS_uc010nfs.2_RNA|SMS_uc010nft.2_Nonsense_Mutation_p.Q27*	NM_004595	NP_004586	P52788	SPSY_HUMAN	spermine synthase	250					methionine metabolic process|spermine biosynthetic process	cytosol	spermidine synthase activity|spermine synthase activity			ovary(1)	1					Spermine(DB00127)	AGACTGCTATCAGGTAATTGT	0.343000													19	88					0	0	0.00074312	0	0
DDX53	168400	broad.mit.edu	37	X	23018769	23018769	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:23018769G>A	uc004daj.2	+	1	683	c.595G>A	c.(595-597)GAA>AAA	p.E199K		NM_182699	NP_874358	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	199						nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			large_intestine(1)|ovary(1)|kidney(1)	3						CTGGAGAAAGGAAAATTTCAA	0.388000													36	86					0	0	0.00148497	0	0
DYNLT3	6990	broad.mit.edu	37	X	37699884	37699884	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:37699884C>T	uc004dds.2	-	5	421	c.295G>A	c.(295-297)GAG>AAG	p.E99K		NM_006520	NP_006511	P51808	DYLT3_HUMAN	dynein, light chain, Tctex-type 3	99					cell division|mitosis|regulation of mitotic cell cycle|transport	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|nucleus|plasma membrane	motor activity				0						GTCCGGTTCTCCCATCTTACG	0.303000													7	20					0	0	0.00307968	0	0
CFP	5199	broad.mit.edu	37	X	47487668	47487668	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:47487668C>T	uc004dig.3	-	3	362	c.236G>A	c.(235-237)CGA>CAA	p.R79Q	CFP_uc004dih.2_Missense_Mutation_p.R79Q|CFP_uc004dii.1_Missense_Mutation_p.R15Q|CFP_uc010nhu.2_Missense_Mutation_p.R79Q	NM_001145252	NP_001138724	P27918	PROP_HUMAN	complement factor properdin precursor	79	TSP type-1 1.				complement activation, alternative pathway|defense response to bacterium	extracellular space				breast(2)|lung(1)	3						CAGGGACCATCGTGGGGACCT	0.612000													5	5					0	0	0.00116845	0	0
PRICKLE3	4007	broad.mit.edu	37	X	49034802	49034802	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:49034802C>T	uc004dmy.1	-	6	613	c.587G>A	c.(586-588)GGG>GAG	p.G196E	PRICKLE3_uc011mmv.1_Missense_Mutation_p.G128E|PRICKLE3_uc011mmw.1_Missense_Mutation_p.G115E|PRICKLE3_uc011mmx.1_Missense_Mutation_p.G158E|PRICKLE3_uc011mmy.1_Missense_Mutation_p.G183E	NM_006150	NP_006141	O43900	PRIC3_HUMAN	LIM domain only 6	196	LIM zinc-binding 1.						protein binding|zinc ion binding			breast(1)	1						TGCGATGTCCCCACCTCCAAT	0.567000													7	22					0	0	0.00307968	0	0
DGKK	139189	broad.mit.edu	37	X	50119821	50119821	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:50119821G>A	uc010njr.1	-	24	3268	c.3208C>T	c.(3208-3210)CTC>TTC	p.L1070F		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	1070					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					TCGTCAGAGAGGCTCTCTTGA	0.502000													9	24					0	0	0.000978159	0	0
ALAS2	212	broad.mit.edu	37	X	55043923	55043923	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:55043923C>T	uc004dua.3	-	7	1137	c.999G>A	c.(997-999)ATG>ATA	p.M333I	ALAS2_uc004dub.3_Missense_Mutation_p.M320I|ALAS2_uc004dud.3_Missense_Mutation_p.M296I	NM_000032	NP_000023	P22557	HEM0_HUMAN	5-aminolevulinate synthase 2 isoform a	333					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(1)	1					Glycine(DB00145)	ACATACCATCCATGGAGTGGA	0.328000													34	70					0	0	0.00375469	0	0
FAAH2	158584	broad.mit.edu	37	X	57318998	57318998	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:57318998G>A	uc004dvc.2	+	2	409	c.260G>A	c.(259-261)GGA>GAA	p.G87E		NM_174912	NP_777572	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	87						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			ovary(3)	3						ATGATCAATGGAATTGTCAAG	0.393000										HNSCC(52;0.14)			33	41					0	0	0.00209593	0	0
HEPH	9843	broad.mit.edu	37	X	65412096	65412096	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:65412096G>A	uc011moz.1	+	7	1257	c.1197G>A	c.(1195-1197)ATG>ATA	p.M399I	HEPH_uc004dwn.2_Missense_Mutation_p.M399I|HEPH_uc004dwo.2_Missense_Mutation_p.M129I|HEPH_uc010nkr.2_Missense_Mutation_p.M399I|HEPH_uc011mpa.1_Missense_Mutation_p.M399I	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	396	Extracellular (Potential).|Plastocyanin-like 3.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						ATGGCCCGATGGGGCATGATG	0.507000													14	36					0	0	0.00074312	0	0
PJA1	64219	broad.mit.edu	37	X	68381749	68381749	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:68381749G>A	uc004dxh.2	-	2	1619	c.1333C>T	c.(1333-1335)CGA>TGA	p.R445*	PJA1_uc011mpi.1_Nonsense_Mutation_p.R163*|PJA1_uc004dxg.2_Nonsense_Mutation_p.R257*|PJA1_uc004dxi.2_Nonsense_Mutation_p.R390*	NM_145119	NP_660095	Q8NG27	PJA1_HUMAN	praja 1 isoform a	445							zinc ion binding				0						GATGGTTCTCGAACTTCTTCA	0.577000													51	88					0	0	0.00361006	0	0
ERCC6L	54821	broad.mit.edu	37	X	71427199	71427199	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:71427199C>T	uc004eaq.1	-	2	1515	c.1418G>A	c.(1417-1419)CGA>CAA	p.R473Q	PIN4_uc004eao.1_Intron|ERCC6L_uc004eap.1_Missense_Mutation_p.R350Q	NM_017669	NP_060139	Q2NKX8	ERC6L_HUMAN	excision repair protein ERCC6-like	473	Helicase C-terminal.				cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			ovary(3)	3	Renal(35;0.156)					TCCCTCATCTCGCAGCCTCTT	0.398000													12	55					0	0	0.00244969	0	0
XIST	7503	broad.mit.edu	37	X	73072212	73072212	+	RNA	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:73072212G>A	uc004ebm.1	-	1		c.377C>T				NR_001564				Homo sapiens cDNA: FLJ21545 fis, clone COL06195.												0						CCGCAGCCCCGATGGGCAAAA	0.403000													6	13					0	0	0.00116845	0	0
ATP7A	538	broad.mit.edu	37	X	77245370	77245370	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:77245370A>C	uc004ecx.3	+	4	1412	c.1252A>C	c.(1252-1254)ACT>CCT	p.T418P	ATP7A_uc004ecw.2_Missense_Mutation_p.T418P	NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	418	HMA 4.|Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						TAGCAATGGGACTGTTGAGTA	0.408000													20	93					0	0	0.00152264	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77913245	77913245	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:77913245G>A	uc004edc.1	-	2	969	c.673C>T	c.(673-675)CCA>TCA	p.P225S		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	225							nucleic acid binding|zinc ion binding			ovary(1)	1						GGGGCCTGTGGAAACTCTGAA	0.507000													11	22					0	0	0.00136819	0	0
CYLC1	1538	broad.mit.edu	37	X	83128074	83128074	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:83128074G>A	uc004eei.1	+	4	379	c.358G>A	c.(358-360)GAT>AAT	p.D120N	CYLC1_uc004eeh.1_Missense_Mutation_p.D119N	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	120					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						AAAGTCCAAAGATGAAAAAGG	0.368000													15	11					0	0	0.00244969	0	0
CYLC1	1538	broad.mit.edu	37	X	83128367	83128367	+	Silent	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:83128367G>A	uc004eei.1	+	4	672	c.651G>A	c.(649-651)AAG>AAA	p.K217K	CYLC1_uc004eeh.1_Silent_p.K216K	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	217					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						TACATACAAAGAACAATCCAA	0.308000													5	29					0	0	0.000602214	0	0
RPS6KA6	27330	broad.mit.edu	37	X	83361437	83361437	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:83361437A>G	uc004eej.1	-	15	1378	c.1301T>C	c.(1300-1302)GTT>GCT	p.V434A	RPS6KA6_uc011mqt.1_Missense_Mutation_p.V434A|RPS6KA6_uc011mqu.1_Missense_Mutation_p.V331A	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	434	ATP (By similarity).|Protein kinase 2.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						GTAGGAGCCAACACCAATATC	0.348000													4	11					0	0	0.00024832	0	0
ZNF711	7552	broad.mit.edu	37	X	84525120	84525120	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:84525120G>A	uc004eeo.2	+	8	1423	c.1076G>A	c.(1075-1077)AGG>AAG	p.R359K	ZNF711_uc004eep.2_Missense_Mutation_p.R359K|ZNF711_uc004eeq.2_Missense_Mutation_p.R405K|ZNF711_uc011mqy.1_5'UTR	NM_021998	NP_068838	Q9Y462	ZN711_HUMAN	zinc finger protein 711	359					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			ovary(3)|skin(1)	4						GCCAAAAAGAGGAGAAGGGGA	0.348000													7	28					0	0	0.00198382	0	0
LOC442459	442459	broad.mit.edu	37	X	98975038	98975038	+	RNA	SNP	C	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:98975038C>A	uc011mrd.1	-	8		c.1305G>T				NR_024608				Homo sapiens DNA repair protein mRNA, complete cds.												0						GTTGAACTCCCATTCACCGGC	0.517000													7	17					0.00198382	0.00683498	0.00198382	1	0
TNMD	64102	broad.mit.edu	37	X	99854661	99854661	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:99854661C>T	uc004efy.3	+	7	1127	c.901C>T	c.(901-903)CGT>TGT	p.R301C	TNMD_uc004efz.2_3'UTR	NM_022144	NP_071427	Q9H2S6	TNMD_HUMAN	tenomodulin	301	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						AGTCATCTGTCGTGTCATCAT	0.507000													8	30					0	0	0.000978159	0	0
CENPI	2491	broad.mit.edu	37	X	100375738	100375738	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:100375738C>T	uc004egx.2	+	7	922	c.652C>T	c.(652-654)CGT>TGT	p.R218C	CENPI_uc011mrg.1_Missense_Mutation_p.R218C|CENPI_uc004egy.2_Missense_Mutation_p.R218C	NM_006733	NP_006724	Q92674	CENPI_HUMAN	centromere protein I	218					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			skin(1)	1						CAAACCATTTCGTGTGAGAAA	0.303000													12	89					0	0	0.00400662	0	0
TAF7L	54457	broad.mit.edu	37	X	100532599	100532599	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:100532599G>A	uc004ehb.2	-	9	956	c.944C>T	c.(943-945)TCG>TTG	p.S315L	TAF7L_uc004eha.2_Missense_Mutation_p.S229L|TAF7L_uc004ehc.1_Missense_Mutation_p.S229L	NM_024885	NP_079161	Q5H9L4	TAF7L_HUMAN	TATA box binding protein-associated factor, RNA	315					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			breast(1)	1						AGTACCTGACGAGGTATGACC	0.433000													32	191					0	0	0.00375469	0	0
VSIG1	340547	broad.mit.edu	37	X	107316583	107316583	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:107316583C>T	uc004eno.2	+	5	833	c.672C>T	c.(670-672)ATC>ATT	p.I224I	VSIG1_uc011msk.1_Silent_p.I260I	NM_182607	NP_872413	Q86XK7	VSIG1_HUMAN	V-set and immunoglobulin domain containing 1	224	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						CCTGCGAAATCGATCTCACTT	0.413000													48	222					0	0	0.00361006	0	0
COL4A5	1287	broad.mit.edu	37	X	107846280	107846280	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:107846280C>T	uc004enz.1	+	28	2435	c.2233C>T	c.(2233-2235)CCA>TCA	p.P745S	COL4A5_uc011mso.1_Missense_Mutation_p.P745S|COL4A5_uc004eob.1_Missense_Mutation_p.P353S	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	745	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						ACCCGGCTTTCCAGGACCAAA	0.458000									Alport_syndrome_with_Diffuse_Leiomyomatosis				4	8					0	0	0.00024832	0	0
TRPC5	7224	broad.mit.edu	37	X	111090377	111090377	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:111090377C>T	uc004epl.1	-	6	2584	c.1665G>A	c.(1663-1665)GGG>GGA	p.G555G	TRPC5_uc004epm.1_Silent_p.G555G	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	555	Extracellular (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						CACATCGGATCCCCTTGCAGT	0.403000													51	129					0	0	0.00361006	0	0
DOCK11	139818	broad.mit.edu	37	X	117739215	117739215	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:117739215G>A	uc004eqp.2	+	24	2640	c.2577G>A	c.(2575-2577)ATG>ATA	p.M859I	DOCK11_uc004eqq.2_Missense_Mutation_p.M625I	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	859	DHR-1.				blood coagulation	cytosol	GTP binding			ovary(3)	3						TGCATGCCATGGAGATCCAAG	0.328000													17	130					0	0	0.00074312	0	0
AIFM1	9131	broad.mit.edu	37	X	129263945	129263945	+	Silent	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:129263945C>T	uc004evg.2	-	15	1948	c.1770G>A	c.(1768-1770)AAG>AAA	p.K590K	AIFM1_uc011mur.1_Silent_p.K238K|AIFM1_uc011mus.1_3'UTR|AIFM1_uc004evh.2_Silent_p.K586K|AIFM1_uc004evi.2_Silent_p.K303K|AIFM1_uc004evk.2_RNA	NM_004208	NP_004199	O95831	AIFM1_HUMAN	programmed cell death 8 isoform 1	590					activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			ovary(4)|central_nervous_system(1)	5						AGGCACCTACCTTCCTTGCTA	0.502000													14	89					0	0	0.000566183	0	0
ZNF280C	55609	broad.mit.edu	37	X	129349848	129349848	+	Silent	SNP	A	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:129349848A>G	uc004evm.2	-	14	1909	c.1755T>C	c.(1753-1755)GCT>GCC	p.A585A	ZNF280C_uc010nrf.1_Silent_p.A536A	NM_017666	NP_060136	Q8ND82	Z280C_HUMAN	zinc finger protein 280C	585					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)	3						CTTTGGACTTAGCTATACGTC	0.373000													38	195					0	0	0.00128727	0	0
OR13H1	347468	broad.mit.edu	37	X	130678868	130678868	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:130678868C>T	uc011muw.1	+	1	821	c.821C>T	c.(820-822)TCA>TTA	p.S274L	IGSF1_uc004ewf.2_Intron	NM_001004486	NP_001004486	Q8NG92	O13H1_HUMAN	olfactory receptor, family 13, subfamily H,	274	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Acute lymphoblastic leukemia(192;0.000636)					AAGTTTATCTCAGTGTTTTAT	0.433000													40	96					0	0	0.00195071	0	0
ZNF75D	7626	broad.mit.edu	37	X	134426375	134426375	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:134426375C>T	uc004eyp.2	-	4	3091	c.436G>A	c.(436-438)GAG>AAG	p.E146K	ZNF75D_uc004eym.2_Intron|ZNF75D_uc004eyn.2_5'UTR|ZNF75D_uc004eyo.2_Intron	NM_007131	NP_009062	P51815	ZN75D_HUMAN	zinc finger protein 75	146					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGCACTGCCTCCTTTCCCAGC	0.512000													13	75					0	0	0.000566183	0	0
GPR112	139378	broad.mit.edu	37	X	135428079	135428079	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:135428079T>A	uc004ezu.1	+	6	2505	c.2214T>A	c.(2212-2214)AAT>AAA	p.N738K	GPR112_uc010nsb.1_Missense_Mutation_p.N533K|GPR112_uc010nsc.1_Missense_Mutation_p.N505K	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	738	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					GGTTTGCTAATTTCTCCATAG	0.388000													13	56					0	0	0.00316338	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092879	151092879	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:151092879C>T	uc004fez.2	+	3	899	c.743C>T	c.(742-744)ACC>ATC	p.T248I	MAGEA4_uc004ffa.2_Missense_Mutation_p.T248I|MAGEA4_uc004ffb.2_Missense_Mutation_p.T248I|MAGEA4_uc004ffc.2_Missense_Mutation_p.T248I|MAGEA4_uc004ffd.2_Missense_Mutation_p.T248I	NM_002362	NP_002353	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	248	MAGE.						protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AAACTGCTCACCCAAGATTGG	0.587000													20	76					0	0	0.00121646	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303936	151303936	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:151303936G>A	uc004ffk.2	-	5	565	c.157C>T	c.(157-159)CCC>TCC	p.P53S	MAGEA10_uc004ffl.2_Missense_Mutation_p.P53S	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	53											0	Acute lymphoblastic leukemia(192;6.56e-05)					gaggaggagggaaaagaggat	0.413000													12	47					0	0	0.000978159	0	0
ZNF185	7739	broad.mit.edu	37	X	152128332	152128332	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:152128332G>A	uc010ntv.1	+	17	1533	c.1496G>A	c.(1495-1497)GGA>GAA	p.G499E	ZNF185_uc011myg.1_Missense_Mutation_p.G531E|ZNF185_uc011myh.1_Missense_Mutation_p.G502E|ZNF185_uc011myi.1_Missense_Mutation_p.G470E|ZNF185_uc011myj.1_Missense_Mutation_p.G440E|ZNF185_uc011myk.1_Missense_Mutation_p.G500E|ZNF185_uc004fgw.3_Missense_Mutation_p.G278E|ZNF185_uc004fgu.2_Missense_Mutation_p.G128E|ZNF185_uc004fgv.2_Missense_Mutation_p.G196E|ZNF185_uc004fgx.2_Missense_Mutation_p.G137E	NM_007150	NP_009081	O15231	ZN185_HUMAN	zinc finger protein 185	499						cytoplasm|cytoskeleton|focal adhesion	zinc ion binding			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GGTGGCCAAGGAGACCCAGCT	0.592000													5	24					0	0	0.000602214	0	0
PLXNB3	5365	broad.mit.edu	37	X	153032887	153032887	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:153032887C>T	uc004fii.2	+	3	779	c.605C>T	c.(604-606)CCC>CTC	p.P202L	PLXNB3_uc011mzb.1_Intron|PLXNB3_uc011mzc.1_Intron|PLXNB3_uc010nuk.2_Missense_Mutation_p.P225L|PLXNB3_uc011mzd.1_Intron	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	202	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					GGGGTGCCACCCCTGGCCATC	0.711000													4	25					0	0	0.00024832	0	0
F8	2157	broad.mit.edu	37	X	154159922	154159922	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:154159922C>T	uc004fmt.2	-	14	2314	c.2143G>A	c.(2143-2145)GAC>AAC	p.D715N		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	715	F5/8 type A 2.|Plastocyanin-like 4.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TTCCGAAAGTCTGAGTTGTGG	0.423000													23	44					0	0	0.00395357	0	0
VAMP7	6845	broad.mit.edu	37	X	155127812	155127812	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:155127812G>A	uc004fnr.2	+	4	415	c.241G>A	c.(241-243)GAG>AAG	p.E81K	VAMP7_uc004fnt.2_Missense_Mutation_p.E40K|VAMP7_uc011naa.1_Missense_Mutation_p.E42K|VAMP7_uc011nab.1_5'UTR|VAMP7_uc004fns.2_Missense_Mutation_p.E81K|VAMP7_uc011nac.1_Missense_Mutation_p.E14K	NM_005638	NP_005629	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7 isoform 1	81	Longin.|Cytoplasmic (Potential).				calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TTTTCTGAATGAGATAAAGAA	0.398000													15	86					0	0	0.00074312	0	0
C1orf173	127254	broad.mit.edu	37	1	75037784	75037784	+	Frame_Shift_Del	DEL	G	-	-			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:75037784delG	uc001dgg.2	-	14	3829	c.3610delC	c.(3610-3612)CTGfs	p.L1204fs		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1204	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CCTTCCTTCAGGGCCCTATTC	0.587													48	149	---	---	---	---					
SLCO1C1	53919	broad.mit.edu	37	12	20874883	20874883	+	Frame_Shift_Del	DEL	T	-	-			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:20874883delT	uc001rej.3	+	9	1276	c.921delT	c.(919-921)GATfs	p.D307fs	SLCO1C1_uc010sii.1_Frame_Shift_Del_p.D307fs|SLCO1C1_uc010sij.1_Frame_Shift_Del_p.D258fs|SLCO1C1_uc009zip.2_Frame_Shift_Del_p.D141fs|SLCO1C1_uc001rei.2_Frame_Shift_Del_p.D307fs|SLCO1C1_uc010sik.1_Frame_Shift_Del_p.D189fs	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	307	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					GTAGAGAGGATTCTAATTCTT	0.398													9	33	---	---	---	---					
ERBB3	2065	broad.mit.edu	37	12	56490961	56490962	+	Frame_Shift_Ins	INS	-	G	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:56490961_56490962insG	uc001sjh.2	+	20	2600_2601	c.2407_2408insG	c.(2407-2409)CGGfs	p.R803fs	ERBB3_uc009zoj.2_Intron|ERBB3_uc010sqb.1_Frame_Shift_Ins_p.R160fs|ERBB3_uc010sqc.1_Frame_Shift_Ins_p.R744fs|ERBB3_uc009zok.2_Intron|ERBB3_uc001sjk.2_Frame_Shift_Ins_p.R44fs	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	803	Cytoplasmic (Potential).|Protein kinase.				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			GAGACAACACCGGGGGGCACTG	0.540													17	69	---	---	---	---					
KIAA1715	80856	broad.mit.edu	37	2	176857060	176857060	+	Frame_Shift_Del	DEL	A	-	-			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:176857060delA	uc002ukc.1	-	4	349	c.156delT	c.(154-156)GTTfs	p.V52fs	KIAA1715_uc010zer.1_Frame_Shift_Del_p.V52fs|KIAA1715_uc010fqw.1_Frame_Shift_Del_p.V118fs|KIAA1715_uc010zes.1_Intron|KIAA1715_uc002ukd.1_Intron|KIAA1715_uc010zet.1_RNA	NM_030650	NP_085153	Q9C0E8	LNP_HUMAN	Lunapark	52	Helical; (Potential).					integral to membrane	protein binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0793)			ACAGATAGAGAACTGAGGAAT	0.323													14	40	---	---	---	---					
SLC23A2	9962	broad.mit.edu	37	20	4850569	4850569	+	Frame_Shift_Del	DEL	G	-	-	rs138961929		TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:4850569delG	uc002wlg.1	-	12	1608	c.1233delC	c.(1231-1233)CCCfs	p.P411fs	SLC23A2_uc010zqr.1_Frame_Shift_Del_p.P296fs|SLC23A2_uc002wlh.1_Frame_Shift_Del_p.P411fs|SLC23A2_uc002wli.2_Frame_Shift_Del_p.P410fs	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	411					L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						TTGCGTGGATGGGGGGGGGTG	0.527													9	157	---	---	---	---					
KLHL24	54800	broad.mit.edu	37	3	183390139	183390139	+	Frame_Shift_Del	DEL	T	-	-			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:183390139delT	uc003flv.2	+	7	1764	c.1469delT	c.(1468-1470)ATTfs	p.I490fs	KLHL24_uc003flw.2_Frame_Shift_Del_p.I490fs|KLHL24_uc003flx.2_Frame_Shift_Del_p.I490fs	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	490	Kelch 4.					axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			GCTATCCCAATTGCCAAAAGG	0.348													9	72	---	---	---	---					
TPRN	286262	broad.mit.edu	37	9	140094220	140094221	+	Frame_Shift_Ins	INS	-	GG	GG			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:140094220_140094221insGG	uc004clt.2	-	1	760_761	c.760_761insCC	c.(760-762)CTCfs	p.L254fs	TPRN_uc004clu.2_Frame_Shift_Ins_p.L254fs	NM_173691	NP_775962	Q4KMQ1	TPRN_HUMAN	hypothetical protein LOC286262 isoform 2	315					sensory perception of sound	stereocilium					0						CCGGGCCTGGAGGTCCCCCAAG	0.653													9	23	---	---	---	---					
MAGEC1	9947	broad.mit.edu	37	X	140994844	140994846	+	In_Frame_Del	DEL	CCT	-	-			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:140994844_140994846delCCT	uc004fbt.2	+	4	1940_1942	c.1654_1656delCCT	c.(1654-1656)CCTdel	p.P553del	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	553							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCAGAGCCCTCCTCAGGGGG	0.567										HNSCC(15;0.026)			8	382	---	---	---	---					
CD99L2	83692	broad.mit.edu	37	X	149937526	149937528	+	In_Frame_Del	DEL	GGC	-	-	rs7877654	byFrequency	TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:149937526_149937528delGGC	uc004fel.2	-	11	886_888	c.768_770delGCC	c.(766-771)CCGCCC>CCC	p.256_257PP>P	CD99L2_uc004fek.2_RNA|CD99L2_uc004fem.2_In_Frame_Del_p.207_208PP>P|CD99L2_uc004fen.2_In_Frame_Del_p.184_185PP>P|CD99L2_uc004feo.2_RNA|CD99L2_uc011myb.1_In_Frame_Del_p.183_184PP>P	NM_031462	NP_113650	Q8TCZ2	C99L2_HUMAN	CD99 antigen-like 2 isoform E3'-E4'-E3-E4	256_257	Cytoplasmic (Potential).|Poly-Pro.				cell adhesion	cell junction|integral to membrane				large_intestine(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GGCTGGTTCGGGCGGCGGCGGCG	0.611													7	241	---	---	---	---					
