Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AGRN	375790	broad.mit.edu	37	1	979052	979052	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:979052C>A	uc001ack.1	+	9	1788	c.1738C>A	c.(1738-1740)CTG>ATG	p.L580M		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	580	Kazal-like 6.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CGAGTGCATGCTGCACGTGCA	0.701													14	33					2.23348e-06	2.33984e-05	0.000422831	1	0
VWA1	64856	broad.mit.edu	37	1	1374540	1374540	+	Silent	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:1374540C>T	uc001afs.2	+	3	931	c.711C>T	c.(709-711)ACC>ACT	p.T237T	VWA1_uc001afr.2_Silent_p.T25T	NM_022834	NP_073745	Q6PCB0	VWA1_HUMAN	von Willebrand factor A domain containing 1	237	Fibronectin type-III 1.					basement membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CCCTGCTGACCGCAGACTCGG	0.701													9	13					0	0	0.000673444	0	0
SLC25A34	284723	broad.mit.edu	37	1	16065769	16065769	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:16065769G>T	uc001axb.1	+	5	955	c.783G>T	c.(781-783)CAG>CAT	p.Q261H	SLC25A34_uc009vok.1_RNA	NM_207348	NP_997231	Q6PIV7	S2534_HUMAN	solute carrier family 25, member 34	261	Solcar 3.				transport	integral to membrane|mitochondrial inner membrane					0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCTGGCGGCAGGAGGGCCCCC	0.652													11	24					1.58986e-06	1.6879e-05	0.000673444	1	0
ARHGEF10L	55160	broad.mit.edu	37	1	17981197	17981197	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:17981197C>A	uc001ban.2	+	23	2620	c.2461C>A	c.(2461-2463)CTT>ATT	p.L821I	ARHGEF10L_uc009vpe.1_Missense_Mutation_p.L782I|ARHGEF10L_uc001bao.2_Missense_Mutation_p.L782I|ARHGEF10L_uc001bap.2_Missense_Mutation_p.L777I|ARHGEF10L_uc001baq.2_Missense_Mutation_p.L582I|ARHGEF10L_uc010ocs.1_Missense_Mutation_p.L594I|ARHGEF10L_uc001bar.2_Missense_Mutation_p.L524I|ARHGEF10L_uc009vpf.2_RNA	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	821					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		CAGCACCTCCCTTCCACAGGG	0.622													40	69					5.44703e-19	1.1723e-17	0.000437636	1	0
EPHB2	2048	broad.mit.edu	37	1	23235514	23235514	+	Splice_Site	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:23235514G>T	uc009vqj.1	+	13	2498	c.2353_splice	c.e13-1	p.G785_splice	EPHB2_uc001bge.2_Splice_Site_p.G786_splice|EPHB2_uc001bgf.2_Splice_Site_p.G785_splice|EPHB2_uc010odu.1_Splice_Site_p.G727_splice	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor						axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		CTGTCTCCCAGGGCGGAAAGA	0.428									Hereditary_Prostate_Cancer				4	7					0.000602214	0.00527604	0.000602214	1	0
TCEA3	6920	broad.mit.edu	37	1	23720379	23720379	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:23720379G>A	uc001bgx.1	-	8	947	c.812C>T	c.(811-813)ACG>ATG	p.T271M	TCEA3_uc009vqm.1_Missense_Mutation_p.T40M	NM_003196	NP_003187	O75764	TCEA3_HUMAN	transcription elongation factor A (SII), 3	271	TFIIS central.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation, DNA-dependent	nucleus	DNA binding|translation elongation factor activity|zinc ion binding				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.16e-05)|all_lung(284;6.68e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.0054)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.6e-25)|Colorectal(126;8.32e-08)|COAD - Colon adenocarcinoma(152;4.29e-06)|GBM - Glioblastoma multiforme(114;9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00424)|STAD - Stomach adenocarcinoma(196;0.0145)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0963)|LUSC - Lung squamous cell carcinoma(448;0.198)		CACCTCTGCCGTCATCTTGGC	0.637													15	6					0	0	0.000219431	0	0
TRNAU1AP	54952	broad.mit.edu	37	1	28887878	28887878	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:28887878C>A	uc001bqi.2	+	4	340	c.246C>A	c.(244-246)AAC>AAA	p.N82K	TRNAU1AP_uc001bqh.2_5'UTR|TRNAU1AP_uc010ofw.1_5'UTR	NM_017846	NP_060316	Q9NX07	TSAP1_HUMAN	tRNA selenocysteine associated protein 1	82	RRM 1.				selenocysteine incorporation	cytoplasm|nucleus	nucleotide binding|RNA binding				0						TTAAACTGAACTATGCCACTT	0.378													11	19					2.32078e-09	3.05326e-08	0.000308642	1	0
MYCL1	4610	broad.mit.edu	37	1	40363545	40363545	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:40363545G>T	uc001cer.1	-	3	811	c.594C>A	c.(592-594)CCC>CCA	p.P198P	MYCL1_uc001ces.1_Silent_p.P198P	NM_001033082	NP_001028254	P12524	MYCL1_HUMAN	l-myc-1 proto-oncogene isoform 1	198						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|liver(1)	2	all_cancers(7;1.73e-14)|all_lung(5;2.77e-17)|all_epithelial(6;6.81e-17)|Lung SC(1;2.85e-13)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.51e-19)|Epithelial(16;3.36e-18)|all cancers(16;8.43e-17)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GCTTCATGCAGGGATCCAGGG	0.522			A		small cell lung 								30	44					5.60225e-13	9.09217e-12	0.000279167	1	0
SLC2A1	6513	broad.mit.edu	37	1	43396303	43396303	+	Silent	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:43396303G>A	uc001cik.2	-	4	1035	c.510C>T	c.(508-510)ATC>ATT	p.I170I		NM_006516	NP_006507	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose	170	Helical; Name=5; (Potential).				carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(2)|pancreas(2)|ovary(1)	5	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	TTACCTGGGCGATGAGGATGC	0.642													13	5					0	0	0.000219431	0	0
FAF1	11124	broad.mit.edu	37	1	51323654	51323654	+	Nonsense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:51323654C>A	uc009vyx.1	-	3	124	c.61G>T	c.(61-63)GAA>TAA	p.E21*	FAF1_uc009vyw.1_RNA|FAF1_uc001cse.1_Nonsense_Mutation_p.E21*	NM_007051	NP_008982	Q9UNN5	FAF1_HUMAN	FAS-associated factor 1	21					apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity	p.0?(2)		ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		TCAATGTTTTCAATGCCAGTA	0.279													19	32					7.45023e-12	1.13911e-10	0.000175454	1	0
ODF2L	57489	broad.mit.edu	37	1	86852689	86852689	+	Nonsense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:86852689C>A	uc001dll.1	-	2	362	c.22G>T	c.(22-24)GGA>TGA	p.G8*	ODF2L_uc001dlm.1_Nonsense_Mutation_p.G8*|ODF2L_uc001dln.2_Nonsense_Mutation_p.G8*|ODF2L_uc001dlo.2_5'UTR|ODF2L_uc001dlp.2_Nonsense_Mutation_p.G8*|ODF2L_uc010osg.1_Nonsense_Mutation_p.G8*|ODF2L_uc001dlq.1_Intron|ODF2L_uc009wcr.1_Intron	NM_020729	NP_065780	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like isoform	8						centrosome				ovary(1)	1				all cancers(265;0.0313)|Epithelial(280;0.0611)		GAATGACTTCCATCATTTACA	0.368													25	31					3.01185e-09	3.89769e-08	0.000586117	1	0
BTBD8	284697	broad.mit.edu	37	1	92612820	92612820	+	Nonsense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:92612820C>A	uc001doo.2	+	8	1281	c.1014C>A	c.(1012-1014)TGC>TGA	p.C338*	BTBD8_uc010otc.1_RNA	NM_183242	NP_899065	Q5XKL5	BTBD8_HUMAN	BTB (POZ) domain containing 8	338						nucleus				ovary(1)	1		all_lung(203;0.0484)|Lung NSC(277;0.126)|Glioma(108;0.222)		all cancers(265;0.0153)|Epithelial(280;0.0982)		TTGCTGACTGCATGAAGTAAG	0.353													25	49					2.79863e-10	3.91611e-09	0.000720815	1	0
F3	2152	broad.mit.edu	37	1	94997946	94997946	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:94997946G>T	uc001dqr.2	-	5	861	c.682C>A	c.(682-684)CGA>AGA	p.R228R	F3_uc001dqp.2_RNA|F3_uc001dqq.2_Intron|F3_uc001dqs.2_Intron	NM_001993	NP_001984	P13726	TF_HUMAN	coagulation factor III precursor	228	Extracellular (Potential).				activation of caspase activity|activation of plasma proteins involved in acute inflammatory response|anti-apoptosis|blood coagulation, extrinsic pathway|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of protein kinase B signaling cascade	extracellular matrix|extracellular space|integral to membrane	cell surface binding|phospholipid binding|protease binding			central_nervous_system(1)	1		all_lung(203;0.00106)|Lung NSC(277;0.00475)		all cancers(265;0.0232)|Epithelial(280;0.121)	Coagulation factor VIIa(DB00036)	TTAACTGTTCGGGAGGGAATC	0.463													19	28					8.34094e-07	8.97557e-06	0.000132079	1	0
GPSM2	29899	broad.mit.edu	37	1	109441298	109441299	+	Missense_Mutation	DNP	CG	AT	AT	rs148114086		TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:109441298_109441299CG>AT	uc010ovc.1	+	6	1088_1089	c.592_593CG>AT	c.(592-594)CGA>ATA	p.R198I	AKNAD1_uc010ovb.1_Intron|GPSM2_uc010ovd.1_Missense_Mutation_p.R198I|GPSM2_uc010ove.1_Missense_Mutation_p.R198I	NM_013296	NP_037428	P81274	GPSM2_HUMAN	LGN protein	198					G-protein coupled receptor protein signaling pathway	cell cortex|nucleus	GTPase activator activity|identical protein binding			central_nervous_system(1)	1		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0353)|Lung(183;0.0984)|COAD - Colon adenocarcinoma(174;0.129)|Epithelial(280;0.175)|all cancers(265;0.209)		TTTGGGTGACCGAGCGGCACAA	0.416													10	442					0	0	6.4e-05	0	0
NRAS	4893	broad.mit.edu	37	1	115256528	115256528	+	Missense_Mutation	SNP	T	G	G	rs121913255		TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:115256528T>G	uc009wgu.2	-	3	437	c.183A>C	c.(181-183)CAA>CAC	p.Q61H		NM_002524	NP_002515	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61	GTP.		Q -> K (in neuroblastoma cell).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(757)|p.Q61K(537)|p.Q61L(147)|p.Q61H(95)|p.Q61P(21)|p.Q61E(9)|p.Q61?(4)|p.Q61Q(3)|p.Q61_E62>HK(1)		haematopoietic_and_lymphoid_tissue(1008)|skin(956)|thyroid(334)|large_intestine(62)|NS(60)|soft_tissue(32)|lung(31)|upper_aerodigestive_tract(25)|urinary_tract(12)|liver(10)|adrenal_gland(9)|autonomic_ganglia(8)|testis(8)|central_nervous_system(8)|prostate(8)|breast(7)|biliary_tract(6)|ovary(6)|stomach(5)|pancreas(5)|endometrium(2)|kidney(2)|cervix(2)|eye(1)	2607	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGTACTCTTCTTGTCCAGCTG	0.463	Q61H(ME1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61H(RD_SOFT_TISSUE)	50	Mis		melanoma|MM|AML|thyroid				Noonan_syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			86	13					0	0	0.000781405	0	0
FAM46C	54855	broad.mit.edu	37	1	118166425	118166425	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:118166425G>T	uc001ehe.2	+	2	1134	c.935G>T	c.(934-936)AGG>ATG	p.R312M		NM_017709	NP_060179	Q5VWP2	FA46C_HUMAN	hypothetical protein LOC54855	312											0	Lung SC(450;0.225)	all_cancers(81;0.000101)|all_lung(203;3.4e-06)|all_epithelial(167;4.98e-06)|Lung NSC(69;2.33e-05)		Lung(183;0.0576)|LUSC - Lung squamous cell carcinoma(189;0.192)|Colorectal(144;0.247)		ATCCTTCGCAGGGTGGTGAAC	0.537										Multiple Myeloma(3;1.13e-06)			18	23					3.32936e-07	3.73492e-06	0.00074312	1	0
TBX15	6913	broad.mit.edu	37	1	119427633	119427633	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:119427633G>T	uc001ehl.1	-	8	1528	c.1213C>A	c.(1213-1215)CTT>ATT	p.L405I	TBX15_uc009whj.1_Missense_Mutation_p.L229I	NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	511						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		GGGTTGTGAAGGGAGAAGGCA	0.532													4	13					1.024e-07	1.20328e-06	0.000602214	1	0
PPIAL4G	644591	broad.mit.edu	37	1	143767477	143767477	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:143767477G>T	uc001ejt.2	-	1	405	c.372C>A	c.(370-372)GGC>GGA	p.G124G		NM_001123068	NP_001116540	A2BFH1	PAL4G_HUMAN	peptidylprolyl isomerase A (cyclophilin A)-like	124	PPIase cyclophilin-type.				protein folding	cytoplasm	peptidyl-prolyl cis-trans isomerase activity				0						CCACATGCTTGCCATCCAACC	0.483													45	492					9.53615e-21	2.22136e-19	0.000781405	1	0
CTSS	1520	broad.mit.edu	37	1	150720281	150720281	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:150720281C>A	uc001evn.2	-	7	1001	c.868G>T	c.(868-870)GGG>TGG	p.G290W	CTSS_uc010pcj.1_Missense_Mutation_p.G240W	NM_004079	NP_004070	P25774	CATS_HUMAN	cathepsin S preproprotein	290					immune response|proteolysis	extracellular region|lysosome	cysteine-type endopeptidase activity				0	all_cancers(9;6.17e-52)|all_epithelial(9;9.7e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.00146)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|Epithelial(6;5.02e-21)|all cancers(9;1.28e-20)|OV - Ovarian serous cystadenocarcinoma(6;1.09e-14)|BRCA - Breast invasive adenocarcinoma(12;0.00501)|LUSC - Lung squamous cell carcinoma(543;0.171)			TATTCTTTCCCATTAAGATCA	0.353													82	49					1.55521e-42	4.8878e-41	0.000781405	1	0
TCHH	7062	broad.mit.edu	37	1	152082565	152082565	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:152082565A>C	uc001ezp.2	-	2	3128	c.3128T>G	c.(3127-3129)CTC>CGC	p.L1043R	TCHH_uc009wne.1_Missense_Mutation_p.L1043R	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1043	10 X 30 AA tandem repeats.|4-5.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCGCTCCTGGAGTCTTCTTTT	0.254													4	98					0	0	8.12818e-05	0	0
TCHH	7062	broad.mit.edu	37	1	152082741	152082741	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:152082741C>A	uc001ezp.2	-	2	2952	c.2952G>T	c.(2950-2952)CAG>CAT	p.Q984H	TCHH_uc009wne.1_Missense_Mutation_p.Q984H	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	984	10 X 30 AA tandem repeats.|4-3.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			tctcccgctcctggcgccttc	0.09													85	44					1.81475e-65	6.039e-64	0.000781405	1	0
KPRP	448834	broad.mit.edu	37	1	152732929	152732929	+	Nonsense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:152732929G>T	uc001fal.1	+	2	923	c.865G>T	c.(865-867)GAA>TAA	p.E289*		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	289	Pro-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			AAGACCCTCTGAAGGTTTCCC	0.597													19	61					9.7654e-05	0.00090777	0.000958276	1	0
SLC27A3	11000	broad.mit.edu	37	1	153748448	153748448	+	Nonsense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:153748448G>T	uc001fcz.2	+	1	681	c.616G>T	c.(616-618)GGA>TGA	p.G206*	SLC27A3_uc009won.2_RNA	NM_024330	NP_077306	Q5K4L6	S27A3_HUMAN	solute carrier family 27 member 3	206					fatty acid metabolic process	integral to membrane|mitochondrial membrane	ligase activity|nucleotide binding			ovary(1)	1	all_lung(78;6.47e-32)|Lung NSC(65;2.52e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CAGAGGTGGAGGAGCCGCCGC	0.726													5	9					0.000602214	0.00527604	0.000602214	1	0
UBAP2L	9898	broad.mit.edu	37	1	154227725	154227725	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:154227725C>A	uc001fep.3	+	17	2174	c.2007C>A	c.(2005-2007)ACC>ACA	p.T669T	UBAP2L_uc009wot.2_Silent_p.T669T|UBAP2L_uc010pek.1_Silent_p.T661T|UBAP2L_uc010pel.1_Silent_p.T679T|UBAP2L_uc010pen.1_Silent_p.T583T|UBAP2L_uc001feq.2_5'UTR|UBAP2L_uc001fer.2_5'Flank	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	669					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TGACGACAACCAATCAGCATT	0.502													114	50					2.51308e-46	8.09088e-45	0.000781405	1	0
IQGAP3	128239	broad.mit.edu	37	1	156513984	156513984	+	Missense_Mutation	SNP	C	A	A	rs147371313		TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:156513984C>A	uc001fpf.2	-	21	2495	c.2420G>T	c.(2419-2421)CGG>CTG	p.R807L		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	807	IQ 3.				small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GTATTGCCTCCGAGCTGCCCA	0.577													6	176					0.000157383	0.00142617	0.000157383	1	0
FCER1A	2205	broad.mit.edu	37	1	159275846	159275846	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:159275846G>T	uc001ftq.2	+	5	499	c.400G>T	c.(400-402)GGT>TGT	p.G134C		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	134	Ig-like 2.|Extracellular (Potential).					integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	CAGGTGCCATGGTTGGAGGAA	0.468													19	56					1.00905e-13	1.71495e-12	0.000132079	1	0
ARHGAP30	257106	broad.mit.edu	37	1	161018682	161018682	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:161018682C>A	uc001fxl.2	-	12	2475	c.2129G>T	c.(2128-2130)AGG>ATG	p.R710M	USF1_uc001fxi.2_5'Flank|USF1_uc001fxj.2_5'Flank|ARHGAP30_uc001fxk.2_Intron|ARHGAP30_uc001fxm.2_Missense_Mutation_p.R556M|ARHGAP30_uc009wtx.2_Missense_Mutation_p.R383M	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	710	Glu-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			TGTCTCTTCCCTACTCCCTTC	0.527													64	243					2.28876e-57	7.55291e-56	0.000781405	1	0
FCGR3B	2215	broad.mit.edu	37	1	161594326	161594326	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:161594326G>T	uc009wul.2	-	5	955	c.681C>A	c.(679-681)TTC>TTA	p.F227L		NM_000570	NP_000561	O75015	FCG3B_HUMAN	low affinity immunoglobulin gamma Fc region	227					immune response	anchored to membrane|extracellular region|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TCTTCACAGAGAAATATAGTC	0.463													88	44					2.5264e-35	7.63707e-34	0.000781405	1	0
LRRC52	440699	broad.mit.edu	37	1	165513559	165513559	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:165513559C>A	uc001gde.2	+	1	82	c.26C>A	c.(25-27)CCT>CAT	p.P9H	LOC400794_uc001gdc.2_Intron|LOC400794_uc001gdd.2_Intron|LOC400794_uc009wvd.2_Intron	NM_001005214	NP_001005214	Q8N7C0	LRC52_HUMAN	leucine rich repeat containing 52 precursor	9						integral to membrane				ovary(1)	1	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)					GGCCCTGGCCCTGGGTGGTTA	0.542													23	111					4.72057e-08	5.59685e-07	0.000586117	1	0
C1orf112	55732	broad.mit.edu	37	1	169790900	169790900	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:169790900G>T	uc001ggp.2	+	10	1093	c.783G>T	c.(781-783)AAG>AAT	p.K261N	C1orf112_uc001ggj.2_RNA|C1orf112_uc001ggq.2_Missense_Mutation_p.K261N|C1orf112_uc009wvt.2_Translation_Start_Site|C1orf112_uc010plu.1_Missense_Mutation_p.K232N|C1orf112_uc009wvu.1_Intron|C1orf112_uc001ggr.2_Missense_Mutation_p.K126N|C1orf112_uc010plv.1_Missense_Mutation_p.K203N	NM_018186	NP_060656	Q9NSG2	CA112_HUMAN	hypothetical protein LOC55732	261											0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					actacgctaaggtaaggcttt	0.149													21	60					2.4624e-09	3.21818e-08	0.000132079	1	0
MYOC	4653	broad.mit.edu	37	1	171605569	171605569	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:171605569C>A	uc001ghu.2	-	3	1033	c.1011G>T	c.(1009-1011)CAG>CAT	p.Q337H	MYOC_uc010pmk.1_Missense_Mutation_p.Q279H	NM_000261	NP_000252	Q99972	MYOC_HUMAN	myocilin precursor	337	Olfactomedin-like.		Q -> E (in GLC1A).|Q -> R (in GLC1A).		anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			lung(1)	1	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					ACTCAGCGCCCTGGAAATAGA	0.537													12	78					1.05317e-09	1.42827e-08	0.000219431	1	0
DNM3	26052	broad.mit.edu	37	1	172357867	172357867	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:172357867C>A	uc001gie.2	+	20	2616	c.2440C>A	c.(2440-2442)CCT>ACT	p.P814T	DNM3_uc001gif.2_Missense_Mutation_p.P810T|DNM3_uc001gih.1_Missense_Mutation_p.P170T	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	820					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						CCCATTACCTCCTTTCCCCAG	0.642													8	20					0.000157383	0.00142617	0.000157383	1	0
CACYBP	27101	broad.mit.edu	37	1	174979205	174979205	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:174979205C>T	uc001gkj.1	+	6	1102	c.677C>T	c.(676-678)ACG>ATG	p.T226M	CACYBP_uc001gki.1_Missense_Mutation_p.T183M	NM_014412	NP_055227	Q9HB71	CYBP_HUMAN	calcyclin binding protein isoform 1	226	SGS.|Interaction with S100A6 (By similarity).|Interaction with SKP1.			T -> P (in Ref. 4; AAG23817).		beta-catenin destruction complex	protein homodimerization activity				0						AAAGGAGACACGGAATTTTGA	0.368													10	60					0	0	0.000978159	0	0
CACNA1E	777	broad.mit.edu	37	1	181708321	181708321	+	Silent	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:181708321C>T	uc001gow.2	+	25	3816	c.3651C>T	c.(3649-3651)TAC>TAT	p.Y1217Y	CACNA1E_uc009wxs.2_Silent_p.Y1105Y|CACNA1E_uc001gox.1_Silent_p.Y443Y|CACNA1E_uc009wxt.2_Silent_p.Y443Y	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1217	III.|Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						ATGGGTCCTACTTCCGAGACT	0.502													73	206					0	0	0.000781405	0	0
FAM129A	116496	broad.mit.edu	37	1	184863270	184863270	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:184863270C>A	uc001gra.2	-	3	451	c.257G>T	c.(256-258)TGG>TTG	p.W86L	FAM129A_uc009wyh.1_Missense_Mutation_p.W86L|FAM129A_uc009wyi.1_Intron	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	86					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						TCTCTCCTTCCACTTCTTTAT	0.353													31	107					1.61788e-16	3.09507e-15	0.000409698	1	0
KCNT2	343450	broad.mit.edu	37	1	196295854	196295854	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:196295854C>A	uc001gtd.1	-	19	2329	c.2269G>T	c.(2269-2271)GAT>TAT	p.D757Y	KCNT2_uc009wyt.1_Intron|KCNT2_uc001gte.1_Missense_Mutation_p.D707Y|KCNT2_uc001gtf.1_Missense_Mutation_p.D757Y|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Missense_Mutation_p.D757Y|KCNT2_uc001gth.1_Missense_Mutation_p.D278Y	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	757	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						TACGGGTTATCCAATAGCAGT	0.303													43	30					4.18559e-23	1.06935e-21	0.000781405	1	0
CFH	3075	broad.mit.edu	37	1	196709892	196709892	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:196709892G>A	uc001gtj.3	+	18	3166	c.2926G>A	c.(2926-2928)GAA>AAA	p.E976K		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	976	Sushi 16.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						ATGCTTAGGAGAAAAATGGTC	0.348													34	128					0	0	0.000953801	0	0
CR1	1378	broad.mit.edu	37	1	207737337	207737337	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:207737337C>T	uc001hfy.2	+	14	2505	c.2365C>T	c.(2365-2367)CGC>TGC	p.R789C	CR1_uc009xcl.1_Intron|CR1_uc001hfx.2_Missense_Mutation_p.R1239C|CR1_uc009xck.1_Intron	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	789	Sushi 12.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						TGCGTCTATGCGCTGCACACC	0.547													17	78					0	0	0.000958276	0	0
TRAF3IP3	80342	broad.mit.edu	37	1	209933495	209933495	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:209933495C>A	uc001hho.2	+	3	401	c.111C>A	c.(109-111)CCC>CCA	p.P37P	TRAF3IP3_uc001hhl.2_Silent_p.P37P|TRAF3IP3_uc001hhm.1_Silent_p.P37P|TRAF3IP3_uc001hhn.2_Silent_p.P37P|TRAF3IP3_uc009xcr.2_Silent_p.P37P	NM_025228	NP_079504	Q9Y228	T3JAM_HUMAN	TRAF3-interacting JNK-activating modulator	37	Cytoplasmic (Potential).					integral to membrane	protein binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.045)		GCTGCCGTCCCAATGTGACCA	0.632													11	34					3.07112e-06	3.15886e-05	0.000978159	1	0
TRAF3IP3	80342	broad.mit.edu	37	1	209953951	209953951	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:209953951G>T	uc001hho.2	+	15	1739	c.1449G>T	c.(1447-1449)GAG>GAT	p.E483D	TRAF3IP3_uc001hhn.2_Missense_Mutation_p.E463D|TRAF3IP3_uc009xcr.2_Missense_Mutation_p.E483D	NM_025228	NP_079504	Q9Y228	T3JAM_HUMAN	TRAF3-interacting JNK-activating modulator	483	Cytoplasmic (Potential).|Potential.					integral to membrane	protein binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.045)		AGGAAAAGGAGGTGAGAGGGT	0.493													10	56					4.68919e-08	5.59313e-07	0.000673444	1	0
MARK1	4139	broad.mit.edu	37	1	220826477	220826477	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:220826477G>T	uc001hmn.3	+	16	2368	c.1771G>T	c.(1771-1773)GCT>TCT	p.A591S	MARK1_uc009xdw.2_Missense_Mutation_p.A592S|MARK1_uc010pun.1_Missense_Mutation_p.A591S|MARK1_uc001hmm.3_Missense_Mutation_p.A569S	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	591					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		TTCCCCATCTGCTCACAGTAT	0.498													16	59					3.52763e-06	3.60037e-05	0.000566183	1	0
NLRP3	114548	broad.mit.edu	37	1	247587301	247587301	+	Nonsense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:247587301G>T	uc001icr.2	+	5	694	c.556G>T	c.(556-558)GAG>TAG	p.E186*	NLRP3_uc001ics.2_Nonsense_Mutation_p.E186*|NLRP3_uc001icu.2_Nonsense_Mutation_p.E186*|NLRP3_uc001icw.2_Nonsense_Mutation_p.E186*|NLRP3_uc001icv.2_Nonsense_Mutation_p.E186*|NLRP3_uc010pyw.1_Nonsense_Mutation_p.E184*|NLRP3_uc001ict.1_Nonsense_Mutation_p.E184*	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	186					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GAGGGAGCAGGAGCTTCTGGC	0.567													18	15					8.34094e-07	8.97557e-06	0.000132079	1	0
NLRP3	114548	broad.mit.edu	37	1	247599359	247599359	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:247599359G>T	uc001icr.2	+	8	2724	c.2586G>T	c.(2584-2586)GTG>GTT	p.V862V	NLRP3_uc001ics.2_Intron|NLRP3_uc001icu.2_Silent_p.V862V|NLRP3_uc001icw.2_Silent_p.V805V|NLRP3_uc001icv.2_Intron|NLRP3_uc010pyw.1_Silent_p.V840V	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	862	LRR 5.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GACTCTATGTGGGGGAGAATG	0.488													30	73					7.72975e-29	2.15562e-27	0.000491102	1	0
GAD2	2572	broad.mit.edu	37	10	26508003	26508003	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr10:26508003C>A	uc001isp.2	+	4	821	c.318C>A	c.(316-318)CCC>CCA	p.P106P	GAD2_uc009xkr.2_Silent_p.P106P|GAD2_uc001isq.2_Silent_p.P106P	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	106					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	GAGAAAGGCCCACTTTGGCGT	0.358													27	39					1.75199e-13	2.93977e-12	0.000184323	1	0
ANK3	288	broad.mit.edu	37	10	61834852	61834852	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr10:61834852G>T	uc001jky.2	-	37	5979	c.5787C>A	c.(5785-5787)TTC>TTA	p.F1929L	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1929					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GTTCAGGTTGGAATGGCTTCT	0.408													14	26					3.27435e-08	3.95318e-07	0.000219431	1	0
UNC5B	219699	broad.mit.edu	37	10	73057728	73057728	+	Silent	SNP	G	T	T	rs143540096		TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr10:73057728G>T	uc001jro.2	+	16	2998	c.2553G>T	c.(2551-2553)CTG>CTT	p.L851L	UNC5B_uc001jrp.2_Silent_p.L840L|UNC5B_uc001jrq.1_5'Flank	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	851	Cytoplasmic (Potential).			L -> P (in Ref. 3; BAB14276).	apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						CCACCCAGCTGGGACCTTATG	0.602													8	47					1.12685e-05	0.000112119	0.000274275	1	0
C10orf54	64115	broad.mit.edu	37	10	73511607	73511607	+	Missense_Mutation	SNP	C	T	T	rs141431398		TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr10:73511607C>T	uc001jsd.2	-	6	857	c.716G>A	c.(715-717)GGG>GAG	p.G239E	CDH23_uc001jrx.3_Intron|C10orf54_uc001jse.2_Missense_Mutation_p.G107E|C10orf54_uc009xqm.2_Missense_Mutation_p.G77E	NM_022153	NP_071436	Q9H7M9	GI24_HUMAN	platelet receptor Gi24 precursor	239	Cytoplasmic (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)|central_nervous_system(1)	3						GTTTTCAATCCCTTGAATGTT	0.587													12	17					0	0	0.000308642	0	0
CDH23	64072	broad.mit.edu	37	10	73559348	73559348	+	Nonsense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr10:73559348G>T	uc001jrx.3	+	50	7701	c.7324G>T	c.(7324-7326)GGA>TGA	p.G2442*	CDH23_uc001jsg.3_Nonsense_Mutation_p.G202*|CDH23_uc001jsh.3_Nonsense_Mutation_p.G202*|CDH23_uc001jsi.3_Nonsense_Mutation_p.G202*	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	2442	Cadherin 23.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						GTACAGCCTTGGAGATGGAGA	0.547													9	73					1.76689e-08	2.17295e-07	0.000442599	1	0
LRIT2	340745	broad.mit.edu	37	10	85982090	85982090	+	Silent	SNP	G	T	T	rs74145771	by1000genomes	TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr10:85982090G>T	uc001kcy.2	-	3	1247	c.1239C>A	c.(1237-1239)CCC>CCA	p.P413P	LRIT2_uc010qmc.1_Silent_p.P423P	NM_001017924	NP_001017924	A6NDA9	LRIT2_HUMAN	leucine rich repeat containing 22 precursor	413	Fibronectin type-III.					integral to membrane				ovary(2)	2						TATTGATTCCGGGGCCAATGT	0.552													37	38					4.62619e-21	1.08401e-19	0.000814825	1	0
RGR	5995	broad.mit.edu	37	10	86012746	86012746	+	Silent	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr10:86012746G>A	uc001kdc.1	+	4	530	c.492G>A	c.(490-492)CTG>CTA	p.L164L	RGR_uc001kdd.1_Silent_p.L168L|RGR_uc001kde.1_Silent_p.L164L	NM_001012720	NP_001012738	P47804	RGR_HUMAN	retinal G-protein coupled receptor isoform 2	164	Extracellular (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity|protein binding			ovary(1)	1						GCTGCACCCTGGACTACTCCA	0.587													12	14					0	0	0.000308642	0	0
PLCE1	51196	broad.mit.edu	37	10	95892021	95892021	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr10:95892021C>A	uc001kjk.2	+	3	1931	c.1297C>A	c.(1297-1299)CAT>AAT	p.H433N	PLCE1_uc010qnx.1_Missense_Mutation_p.H433N|PLCE1_uc001kjm.2_Missense_Mutation_p.H125N	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	433					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				CGAGACAGCCCATGGAAGGAT	0.468													30	43					2.65835e-16	5.06108e-15	0.000184323	1	0
DNTT	1791	broad.mit.edu	37	10	98092351	98092351	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr10:98092351C>A	uc001kmf.2	+	9	1527	c.1357C>A	c.(1357-1359)CGG>AGG	p.R453R	DNTT_uc001kmg.2_Silent_p.R453R	NM_004088	NP_004079	P04053	TDT_HUMAN	terminal deoxynucleotidyltransferase isoform 1	453	Mediates interaction with DNTTIP2.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		GACTGGCTCCCGGGTAAGTGC	0.582													28	65					3.90053e-15	7.15097e-14	0.000409698	1	0
PSD	5662	broad.mit.edu	37	10	104176550	104176550	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr10:104176550G>T	uc001kvg.1	-	2	773	c.246C>A	c.(244-246)CCC>CCA	p.P82P	PSD_uc001kvh.1_Intron|PSD_uc009xxd.1_Silent_p.P82P|PSD_uc001kvi.1_Silent_p.P82P|FBXL15_uc001kvj.1_5'Flank	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	82	Pro-rich.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		AGGGTGCCCAGGGTGAGGGAG	0.662													24	30					3.28513e-13	5.44314e-12	0.000586117	1	0
FGFR2	2263	broad.mit.edu	37	10	123325091	123325091	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr10:123325091C>A	uc010qtk.1	-	3	884	c.237G>T	c.(235-237)TTG>TTT	p.L79F	FGFR2_uc010qtg.1_Missense_Mutation_p.L79F|FGFR2_uc010qth.1_Intron|FGFR2_uc010qti.1_Intron|FGFR2_uc010qtj.1_Missense_Mutation_p.L79F|FGFR2_uc010qtl.1_Missense_Mutation_p.L79F|FGFR2_uc010qtm.1_Intron|FGFR2_uc001lfl.3_Missense_Mutation_p.L79F|FGFR2_uc001lfm.2_Intron|FGFR2_uc001lfn.3_Intron|FGFR2_uc010qtn.1_Missense_Mutation_p.L98F|FGFR2_uc010qto.1_Intron|FGFR2_uc001lfo.1_Missense_Mutation_p.L98F|FGFR2_uc010qtp.1_Missense_Mutation_p.L98F|FGFR2_uc010qtq.1_Missense_Mutation_p.L98F	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	79	Ig-like C2-type 1.|Extracellular (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	TGTTGGGCCCCAAGTGCACCC	0.567		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				31	58					9.04072e-19	1.9145e-17	0.00058488	1	0
TCERG1L	256536	broad.mit.edu	37	10	133106588	133106588	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr10:133106588G>T	uc001lkp.2	-	3	642	c.556C>A	c.(556-558)CAT>AAT	p.H186N		NM_174937	NP_777597	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	186										large_intestine(2)|ovary(2)	4		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		TCATGCCCATGGAAAAACCTT	0.493													16	41					1.99824e-07	2.28041e-06	0.000566183	1	0
EFCAB4A	283229	broad.mit.edu	37	11	828772	828772	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:828772G>T	uc001lrv.2	+	1	543	c.165G>T	c.(163-165)CAG>CAT	p.Q55H	EFCAB4A_uc010qwt.1_Missense_Mutation_p.Q55H|EFCAB4A_uc009ycm.1_Missense_Mutation_p.Q55H|EFCAB4A_uc001lrw.2_5'Flank			Q8N4Y2	EFC4A_HUMAN	RecName: Full=EF-hand calcium-binding domain-containing protein 4A;	55	EF-hand 1.				store-operated calcium entry		calcium ion binding				0		all_cancers(49;2.31e-08)|all_epithelial(84;3.72e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.179)|all_lung(207;0.227)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACGACCTGCAGGTGAGTCCCC	0.637													17	40					2.94398e-08	3.5982e-07	0.000958276	1	0
KRTAP5-4	387267	broad.mit.edu	37	11	1643370	1643370	+	Splice_Site	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:1643370G>T	uc009ycy.1	-	1	1	c.-86_splice	c.e1-1			NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4							keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CAGATGAGATGGAGGTGCAGG	0.498													21	39					8.10497e-08	9.55229e-07	0.000175454	1	0
KCNQ1	3784	broad.mit.edu	37	11	2604676	2604676	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:2604676C>A	uc001lwn.2	+	7	1041	c.933C>A	c.(931-933)ACC>ACA	p.T311T	KCNQ1_uc009ydp.1_Silent_p.T95T|KCNQ1_uc001lwo.2_Silent_p.T184T	NM_000218	NP_000209	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like	311			T -> I (in LQT1).		blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			ovary(1)	1		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	TCACAGTCACCACCATCGGCT	0.617													73	112					3.20846e-33	9.4115e-32	0.000781405	1	0
OR51A4	401666	broad.mit.edu	37	11	4967462	4967462	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:4967462G>T	uc010qys.1	-	1	869	c.869C>A	c.(868-870)CCA>CAA	p.P290Q		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,	290	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATAAACAATTGGGTTCGTCAG	0.423													14	110					2.32078e-09	3.05326e-08	0.000308642	1	0
OR52J3	119679	broad.mit.edu	37	11	5067867	5067867	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:5067867C>A	uc010qyv.1	+	1	112	c.112C>A	c.(112-114)CTT>ATT	p.L38I		NM_001001916	NP_001001916	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J,	38	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|lung(1)|skin(1)	3		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTCTGTTTACCTTGTGGCTTT	0.488													10	37					2.17888e-05	0.000211999	0.000442599	1	0
OR51B5	282763	broad.mit.edu	37	11	5364502	5364502	+	Silent	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:5364502G>A	uc001map.1	-	1	253	c.253C>T	c.(253-255)CTG>TTG	p.L85L	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Silent_p.L85L	NM_001005567	NP_001005567	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B,	85	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGTGATCCAGCCAGAGGACT	0.557													19	11					0	0	0.00074312	0	0
OR52E6	390078	broad.mit.edu	37	11	5862851	5862851	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:5862851C>T	uc010qzq.1	-	1	277	c.277G>A	c.(277-279)GAA>AAA	p.E93K	TRIM5_uc001mbq.1_Intron	NM_001005167	NP_001005167	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAAGATATTTCCTTGATATTG	0.473													53	67					0	0	0.000781405	0	0
CCKBR	887	broad.mit.edu	37	11	6292680	6292680	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:6292680C>A	uc001mcp.2	+	5	1444	c.1251C>A	c.(1249-1251)CCC>CCA	p.P417P	CCKBR_uc001mcq.2_Silent_p.P345P|CCKBR_uc001mcr.2_Silent_p.P400P|CCKBR_uc001mcs.2_Silent_p.P486P	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	417	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	GAGCTCGCCCCAGGGCTCTTC	0.642													6	36					8.12818e-05	0.000757356	8.12818e-05	1	0
NLRP14	338323	broad.mit.edu	37	11	7065065	7065065	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:7065065C>A	uc001mfb.1	+	4	2131	c.1808C>A	c.(1807-1809)CCA>CAA	p.P603Q		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	603					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		AGATGTTTCCCAAAGGTTGCC	0.418													30	74					1.74807e-11	2.58297e-10	0.000339439	1	0
RASSF10	644943	broad.mit.edu	37	11	13032278	13032278	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:13032278G>T	uc001mkn.1	+	2	1479	c.1479G>T	c.(1477-1479)CTG>CTT	p.L493L		NM_001080521	NP_001073990	A6NK89	RASFA_HUMAN	Ras association (RalGDS/AF-6) domain family	385					signal transduction						0				Epithelial(150;0.00399)		AGCTGCTGCTGGAGCAGGAAC	0.662													5	4					0.000602214	0.00527604	0.000602214	1	0
ABCC8	6833	broad.mit.edu	37	11	17419937	17419937	+	Silent	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:17419937G>A	uc001mnc.2	-	30	3828	c.3702C>T	c.(3700-3702)AAC>AAT	p.N1234N		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1234	ABC transmembrane type-1 2.|Cytoplasmic (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	GGGAAGCAATGTTGTTGGAGT	0.547													88	154					0	0	0.000781405	0	0
DGKZ	8525	broad.mit.edu	37	11	46391559	46391559	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:46391559G>T	uc001ncn.1	+	7	1259	c.1134G>T	c.(1132-1134)AAG>AAT	p.K378N	DGKZ_uc001nch.1_Missense_Mutation_p.K206N|DGKZ_uc010rgq.1_Intron|DGKZ_uc001ncj.1_Missense_Mutation_p.K156N|DGKZ_uc010rgr.1_Missense_Mutation_p.K155N|DGKZ_uc001nck.1_Translation_Start_Site|DGKZ_uc001ncl.2_Missense_Mutation_p.K190N|DGKZ_uc001ncm.2_Missense_Mutation_p.K189N|DGKZ_uc009yky.1_Missense_Mutation_p.K190N|DGKZ_uc010rgs.1_Intron	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	378	Phorbol-ester/DAG-type 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		ACTGTGGGAAGGTGAGAGGCC	0.637											OREG0020942	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	24					0.00010058	0.00092843	0.00010058	1	0
OR4C16	219428	broad.mit.edu	37	11	55340324	55340324	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:55340324C>A	uc010rih.1	+	1	721	c.721C>A	c.(721-723)CAC>AAC	p.H241N		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				ATGTGTCTCCCACATCATTGT	0.393													24	24					2.98393e-07	3.37611e-06	0.000375601	1	0
OR5M10	390167	broad.mit.edu	37	11	56344874	56344874	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:56344874C>A	uc001niz.1	-	1	324	c.324G>T	c.(322-324)GTG>GTT	p.V108V		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	108	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACTCAGTGATCACTAGGGCGA	0.443													27	46					2.41591e-17	4.80754e-16	0.000720815	1	0
CLP1	10978	broad.mit.edu	37	11	57427470	57427470	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:57427470C>A	uc001nkw.2	+	2	661	c.522C>A	c.(520-522)GTC>GTA	p.V174V	CLP1_uc010rjw.1_Intron|CLP1_uc009yml.2_Silent_p.V174V	NM_006831	NP_006822	Q92989	CLP1_HUMAN	ATP/GTP-binding protein isoform 1	174					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|siRNA loading onto RISC involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation	nucleoplasm|tRNA-intron endonuclease complex	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity			ovary(1)	1						CTGCAGATGTCGAAGAGGGTT	0.547													11	13					1.58986e-06	1.6879e-05	0.000673444	1	0
NPAS4	266743	broad.mit.edu	37	11	66189596	66189596	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:66189596C>T	uc001ohx.1	+	2	357	c.181C>T	c.(181-183)CCT>TCT	p.P61S	NPAS4_uc010rpc.1_5'UTR	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	61					transcription, DNA-dependent		DNA binding|signal transducer activity				0						TACAGGCACTCCTCTGGCGGG	0.567													11	21					0	0	0.000219431	0	0
FCHSD2	9873	broad.mit.edu	37	11	72794770	72794770	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:72794770C>G	uc009ytl.2	-	3	356	c.135G>C	c.(133-135)AAG>AAC	p.K45N	FCHSD2_uc010rrg.1_5'UTR|FCHSD2_uc001oth.3_5'UTR|FCHSD2_uc001oti.2_5'UTR	NM_014824	NP_055639	O94868	FCSD2_HUMAN	FCH and double SH3 domains 2	45	FCH.						protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(5;3.3e-05)			TAGCAGCCTTCTTCTGACTGA	0.348													112	166					0	0	0.000781405	0	0
RELT	84957	broad.mit.edu	37	11	73101837	73101837	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:73101837C>A	uc001otv.2	+	4	323	c.158C>A	c.(157-159)CCA>CAA	p.P53Q	RELT_uc001otw.2_Missense_Mutation_p.P53Q|RELT_uc009yto.1_5'UTR|RELT_uc001otx.2_5'Flank	NM_152222	NP_689408	Q969Z4	TR19L_HUMAN	RELT tumor necrosis factor receptor precursor	53	TNFR-Cys.|Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane	binding|receptor activity			upper_aerodigestive_tract(1)	1						CCCTGCCCCCCAGGCACCTTC	0.667													27	27					1.88708e-17	3.79333e-16	0.000227799	1	0
ODZ4	26011	broad.mit.edu	37	11	78369483	78369483	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:78369483C>A	uc001ozl.3	-	34	8393	c.7930G>T	c.(7930-7932)GGG>TGG	p.G2644W	ODZ4_uc001ozk.3_Missense_Mutation_p.G869W|ODZ4_uc009yvb.1_Intron	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	2644	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						ACGTTGACCCCATTCTCCAGG	0.552													9	15					4.68919e-08	5.59313e-07	0.000673444	1	0
DDX10	1662	broad.mit.edu	37	11	108594135	108594135	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:108594135G>T	uc001pkm.2	+	13	1976	c.1911G>T	c.(1909-1911)AAG>AAT	p.K637N	DDX10_uc001pkl.1_Missense_Mutation_p.K637N	NM_004398	NP_004389	Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	637							ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		ATTTCTTGAAGGTGAAGCGGC	0.433			T	NUP98	AML*								19	23					4.63292e-17	9.17319e-16	0.000132079	1	0
FDXACB1	91893	broad.mit.edu	37	11	111749829	111749829	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:111749829C>A	uc001pmc.3	-	1	325	c.28G>T	c.(28-30)GGG>TGG	p.G10W	ALG9_uc010rwo.1_5'UTR|FDXACB1_uc009yyi.2_5'UTR|C11orf1_uc001pmd.2_5'Flank|C11orf1_uc001pme.2_5'Flank	NM_138378	NP_612387	Q9BRP7	FDXA1_HUMAN	ferredoxin-fold anticodon binding domain	10					phenylalanyl-tRNA aminoacylation|tRNA processing		ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding				0						TTCCCCTCCCCAACCAACAGG	0.642											OREG0021330|OREG0010943	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)|type=TRANSCRIPTION FACTOR BINDING SITE|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip); Conservation found by scanning with a motif model	6	22					1.06961e-07	1.24946e-06	0.000157383	1	0
APOA5	116519	broad.mit.edu	37	11	116661594	116661594	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:116661594C>A	uc001ppr.2	-	3	359	c.351G>T	c.(349-351)CTG>CTT	p.L117L	ZNF259_uc001ppp.2_5'Flank|ZNF259_uc009yzd.2_5'Flank|ZNF259_uc001ppq.2_5'Flank|APOA5_uc009yze.2_Silent_p.L117L|APOA5_uc009yzf.2_Silent_p.L117L|APOA5_uc009yzg.2_Silent_p.L143L	NM_052968	NP_443200	Q6Q788	APOA5_HUMAN	apolipoprotein AV precursor	117	Potential.				acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding				0	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)		TCCAGCCCACCAGCTCGTGCG	0.657													86	138					2.5963e-48	8.42735e-47	0.000781405	1	0
FOXRED1	55572	broad.mit.edu	37	11	126142894	126142894	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:126142894G>T	uc001qdi.2	+	3	384	c.337G>T	c.(337-339)GGT>TGT	p.G113C	FOXRED1_uc010sbn.1_Translation_Start_Site|FOXRED1_uc010sbo.1_RNA|FOXRED1_uc010sbp.1_Translation_Start_Site|FOXRED1_uc010sbq.1_Translation_Start_Site|FOXRED1_uc001qdj.2_Translation_Start_Site|FOXRED1_uc010sbr.1_Missense_Mutation_p.G99C|FOXRED1_uc001qdk.2_Translation_Start_Site	NM_017547	NP_060017	Q96CU9	FXRD1_HUMAN	FAD-dependent oxidoreductase domain containing	113						integral to membrane|mitochondrion	oxidoreductase activity|protein binding				0	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0729)		GCTCTCAGTAGGTGGGATTTG	0.463													34	40					2.66277e-13	4.43048e-12	0.000270559	1	0
FLI1	2313	broad.mit.edu	37	11	128651878	128651878	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:128651878C>A	uc010sbu.1	+	5	956	c.615C>A	c.(613-615)ACC>ACA	p.T205T	FLI1_uc010sbt.1_Silent_p.T12T|FLI1_uc010sbv.1_Silent_p.T172T|FLI1_uc009zci.2_Silent_p.T139T	NM_002017	NP_002008	Q01543	FLI1_HUMAN	Friend leukemia virus integration 1	205					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2266)	bone(2210)|soft_tissue(48)|autonomic_ganglia(4)|central_nervous_system(4)|lung(3)|ovary(2)|pancreas(2)	2273	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		ATAATACAACCTCCCACACCG	0.423			T	EWSR1	Ewing sarcoma								40	75					2.69774e-35	8.09323e-34	0.000781405	1	0
KCNJ1	3758	broad.mit.edu	37	11	128709265	128709265	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:128709265G>T	uc001qeo.1	-	2	982	c.931C>A	c.(931-933)CGG>AGG	p.R311R	KCNJ1_uc001qep.1_Silent_p.R292R|KCNJ1_uc001qeq.1_Silent_p.R292R|KCNJ1_uc001qer.1_Silent_p.R292R|KCNJ1_uc001qes.1_Silent_p.R292R	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	311	Cytoplasmic (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	TAGGATGTCCGGACTTGGCAG	0.498													11	29					4.68919e-08	5.59313e-07	0.000673444	1	0
GLB1L2	89944	broad.mit.edu	37	11	134239754	134239754	+	Silent	SNP	T	C	C			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:134239754T>C	uc001qhp.2	+	11	1271	c.1083T>C	c.(1081-1083)CTT>CTC	p.L361L	GLB1L2_uc009zdg.1_RNA	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2 precursor	361					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|pancreas(1)|skin(1)	3	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		ACATGAAGCTTCGAGACTTCT	0.547													14	36					0	0	0.000219431	0	0
TULP3	7289	broad.mit.edu	37	12	3029954	3029954	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:3029954G>T	uc010seh.1	+	3	200	c.119G>T	c.(118-120)AGG>ATG	p.R40M	TULP3_uc010sef.1_RNA|TULP3_uc009zec.1_Intron|TULP3_uc010seg.1_RNA|TULP3_uc001qlj.2_Missense_Mutation_p.R40M|TULP3_uc010sei.1_Intron	NM_003324	NP_003315	O75386	TULP3_HUMAN	tubby like protein 3 isoform 1	40					G-protein coupled receptor protein signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|extracellular region|nucleus|plasma membrane	phosphatidylinositol-4,5-bisphosphate binding				0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			AAGAGGCAAAGGAAAAAGCGC	0.507													40	58					8.04919e-23	1.9798e-21	0.000781405	1	0
CD163L1	283316	broad.mit.edu	37	12	7548983	7548983	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:7548983C>A	uc001qsy.2	-	8	1784	c.1758G>T	c.(1756-1758)GTG>GTT	p.V586V	CD163L1_uc010sge.1_Silent_p.V596V	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	586	SRCR 6.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						TGCTGCCGCCCACCAGCCTCA	0.463													5	13					1.23904e-05	0.00012145	0.000602214	1	0
KLRC3	3823	broad.mit.edu	37	12	10587105	10587105	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:10587105G>T	uc001qyh.2	-	3	318	c.311C>A	c.(310-312)CCG>CAG	p.P104Q	KLRC2_uc010she.1_Missense_Mutation_p.P104Q|KLRC2_uc001qyk.2_Missense_Mutation_p.P104Q	NM_002261	NP_002252	Q07444	NKG2E_HUMAN	killer cell lectin-like receptor subfamily C,	104	Extracellular (Potential).				cellular defense response	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|skin(1)	3						TCTTGTATTCGGGGAAAAATT	0.279													23	67					1.75199e-13	2.93977e-12	0.000184323	1	0
ETV6	2120	broad.mit.edu	37	12	12022795	12022795	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:12022795G>T	uc001qzz.2	+	5	1175	c.901G>T	c.(901-903)GGG>TGG	p.G301W	ETV6_uc001raa.1_Missense_Mutation_p.G94W	NM_001987	NP_001978	P41212	ETV6_HUMAN	ets variant 6	301						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/NTRK3(234)|ETV6/JAK2(11)	soft_tissue(85)|kidney(66)|breast(55)|salivary_gland(26)|haematopoietic_and_lymphoid_tissue(13)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)|pancreas(1)	250		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				GCATAGGGAAGGGAAGCCCAT	0.592			T	NTRK3|RUNX1|PDGFRB|ABL1|MN1|ABL2|FACL6|CHIC2|ARNT|JAK2|EVI1|CDX2|STL|HLXB9|MDS2|PER1|SYK|TTL|FGFR3|PAX5	congenital fibrosarcoma|multiple leukemia and lymphoma| secretory breast|MDS|ALL								30	42					1.45844e-13	2.46812e-12	0.000491102	1	0
EPS8	2059	broad.mit.edu	37	12	15784514	15784514	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:15784514G>T	uc009zif.2	-	18	2000	c.1906C>A	c.(1906-1908)CCC>ACC	p.P636T	EPS8_uc001rdb.2_Missense_Mutation_p.P636T|EPS8_uc009zig.2_Missense_Mutation_p.P376T|EPS8_uc010shv.1_Missense_Mutation_p.P376T	NM_004447	NP_004438	Q12929	EPS8_HUMAN	epidermal growth factor receptor pathway	636	Pro-rich.				cell proliferation|epidermal growth factor receptor signaling pathway		SH3/SH2 adaptor activity			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		all_epithelial(100;1.87e-05)|Breast(259;0.000286)|Hepatocellular(102;0.244)		BRCA - Breast invasive adenocarcinoma(232;4.29e-05)|GBM - Glioblastoma multiforme(207;0.0264)		GGGGGAAGGGGAACAGGAACA	0.507													16	44					1.67942e-08	2.09795e-07	0.00074312	1	0
MRPS35	60488	broad.mit.edu	37	12	27863869	27863869	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:27863869G>T	uc001rih.2	+	1	141	c.93G>T	c.(91-93)CCG>CCT	p.P31P	MRPS35_uc001rii.2_Silent_p.P31P	NM_021821	NP_068593	P82673	RT35_HUMAN	mitochondrial ribosomal protein S35 precursor	31					DNA damage response, detection of DNA damage	mitochondrial small ribosomal subunit					0	Lung SC(9;0.0873)					CGGCCACTCCGGTCCCGACAC	0.652													11	12					6.40141e-05	0.000605002	0.000978159	1	0
C12orf41	54934	broad.mit.edu	37	12	49061513	49061513	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:49061513G>T	uc001rrx.2	-	7	1011	c.936C>A	c.(934-936)TCC>TCA	p.S312S	C12orf41_uc001rrw.2_Silent_p.S117S|C12orf41_uc001rrz.2_Silent_p.S495S|C12orf41_uc001rry.2_RNA|C12orf41_uc001rrv.2_Silent_p.S30S|SNORA2B_uc001rsc.1_5'Flank	NM_017822	NP_060292	Q9H9L4	CL041_HUMAN	hypothetical protein LOC54934	312										ovary(2)	2						GAGACTGATTGGAACAACGAA	0.443													39	54					2.37825e-27	6.54018e-26	0.000509022	1	0
SPATS2	65244	broad.mit.edu	37	12	49890753	49890753	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:49890753G>T	uc001rud.2	+	8	1653	c.664G>T	c.(664-666)GGG>TGG	p.G222W	SPATS2_uc001rue.2_RNA|SPATS2_uc009zli.1_Missense_Mutation_p.G222W|SPATS2_uc001ruf.2_Missense_Mutation_p.G222W|SPATS2_uc001rug.2_Missense_Mutation_p.G222W	NM_023071	NP_075559	Q86XZ4	SPAS2_HUMAN	spermatogenesis associated, serine-rich 2	222						cytoplasm				breast(1)	1						TTCAAATATGGGGATGGAAGA	0.433													19	38					1.28384e-07	1.47362e-06	0.000229342	1	0
NR4A1	3164	broad.mit.edu	37	12	52448610	52448610	+	Silent	SNP	T	G	G			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:52448610T>G	uc001rzs.2	+	3	812	c.498T>G	c.(496-498)ACT>ACG	p.T166T	NR4A1_uc010sno.1_Silent_p.T179T|NR4A1_uc001rzr.2_Silent_p.T166T|NR4A1_uc009zmb.1_Silent_p.T166T|NR4A1_uc001rzt.2_Silent_p.T166T|NR4A1_uc009zmc.2_5'Flank	NM_002135	NP_002126	P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	166					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(357;0.0967)		CCAGCCAGACTTACGAAGGCC	0.692													19	20					0	0	0.000132079	0	0
KRT83	3889	broad.mit.edu	37	12	52710738	52710738	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:52710738G>T	uc001saf.2	-	5	883	c.820C>A	c.(820-822)CTG>ATG	p.L274M		NM_002282	NP_002273	P78385	KRT83_HUMAN	keratin 83	274	Rod.|Linker 12.				epidermis development	keratin filament	structural molecule activity			skin(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TCCATGTTCAGGTCCCGGCTG	0.572													36	59					1.07637e-12	1.71871e-11	0.000953801	1	0
KRT85	3891	broad.mit.edu	37	12	52756730	52756730	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:52756730C>A	uc001sag.2	-	6	1105	c.985G>T	c.(985-987)GGG>TGG	p.G329W		NM_002283	NP_002274	P78386	KRT85_HUMAN	keratin 85	329	Rod.|Coil 2.				epidermis development	keratin filament	protein binding|structural molecule activity			ovary(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		AGGGTCTCCCCATGCCTGATC	0.597													18	21					8.34094e-07	8.97557e-06	0.000132079	1	0
KRT75	9119	broad.mit.edu	37	12	52827670	52827670	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:52827670G>T	uc001saj.2	-	1	441	c.419C>A	c.(418-420)CCC>CAC	p.P140H		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	140	Head.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.192)		CTGGATGGTGGGGTCGATTTG	0.597													18	33					1.01871e-10	1.4723e-09	0.000132079	1	0
KRT6B	3854	broad.mit.edu	37	12	52845496	52845496	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:52845496C>A	uc001sak.2	-	1	415	c.367G>T	c.(367-369)GGG>TGG	p.G123W		NM_005555	NP_005546	P04259	K2C6B_HUMAN	keratin 6B	123	Head.				ectoderm development	keratin filament	structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.083)		CCAGGGCCCCCAAAGCCACCA	0.622													6	26					2.0095e-06	2.11077e-05	8.12818e-05	1	0
KRT6A	3853	broad.mit.edu	37	12	52883769	52883769	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:52883769C>A	uc001sam.2	-	6	1370	c.1161G>T	c.(1159-1161)ATG>ATT	p.M387I		NM_005554	NP_005545	P02538	K2C6A_HUMAN	keratin 6A	387	Rod.|Coil 2.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			ovary(4)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCCTCTGGATCATGCGGTTGA	0.567													5	24					8.12818e-05	0.000757356	8.12818e-05	1	0
PRR13	54458	broad.mit.edu	37	12	53839807	53839807	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:53839807C>A	uc001scz.3	+	4	575	c.411C>A	c.(409-411)TCC>TCA	p.S137S	PRR13_uc001scy.3_Silent_p.S87S|PCBP2_uc010soh.1_Intron|PRR13_uc001sda.3_Silent_p.S137S	NM_018457	NP_060927	Q9NZ81	PRR13_HUMAN	proline rich 13 isoform 1	137	Ser-rich.			S -> P (in Ref. 3; CAE45980).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						AGCATTCCTCCTCTTCCTCCT	0.532													38	51					8.48111e-28	2.34861e-26	0.000781405	1	0
PPP1R1A	5502	broad.mit.edu	37	12	54974740	54974740	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:54974740C>A	uc001sgg.2	-	6	669	c.498G>T	c.(496-498)AAG>AAT	p.K166N		NM_006741	NP_006732	Q13522	PPR1A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	166	Interaction with PPP1R15A.				glycogen metabolic process|signal transduction		protein binding|protein serine/threonine phosphatase inhibitor activity				0						AGTTGGCTCCCTTGGAATCCA	0.512													72	97					2.08929e-35	6.36428e-34	0.000781405	1	0
ITGA7	3679	broad.mit.edu	37	12	56094079	56094079	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:56094079G>T	uc001shh.2	-	5	989	c.769C>A	c.(769-771)CGC>AGC	p.R257S	ITGA7_uc001shg.2_Intron|ITGA7_uc010sps.1_Missense_Mutation_p.R160S|ITGA7_uc009znx.2_Intron	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor	257	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5						GGGATGAGGCGGGGGTCCTGC	0.652													8	10					0.000274275	0.00244624	0.000274275	1	0
LRP1	4035	broad.mit.edu	37	12	57566963	57566963	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:57566963C>A	uc001snd.2	+	21	3642	c.3176C>A	c.(3175-3177)CCT>CAT	p.P1059H		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1059	Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	ACGAGGCCCCCTGGTGGCTGC	0.672											OREG0021936	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	16					1.61879e-10	2.3059e-09	0.00010058	1	0
KERA	11081	broad.mit.edu	37	12	91449766	91449766	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:91449766C>T	uc001tbl.2	-	2	912	c.293G>A	c.(292-294)AGA>AAA	p.R98K		NM_007035	NP_008966	O60938	KERA_HUMAN	keratocan precursor	98	LRR 2.				response to stimulus|visual perception	proteinaceous extracellular matrix				skin(1)	1						ATTTATCCATCTTAGCTGGGT	0.363													30	47					0	0	0.000339439	0	0
OAS3	4940	broad.mit.edu	37	12	113405891	113405891	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:113405891C>T	uc001tug.2	+	14	3103	c.3016C>T	c.(3016-3018)CGC>TGC	p.R1006C		NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	1006	OAS domain 3.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1						CACCCAGTACCGCCAGCTCTG	0.567													16	22					0	0	0.000566183	0	0
NOS1	4842	broad.mit.edu	37	12	117696876	117696876	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:117696876C>A	uc001twm.1	-	15	3113	c.2427G>T	c.(2425-2427)GTG>GTT	p.V809V	NOS1_uc001twn.1_5'Flank	NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	809	Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TGCTGGTGACCACAAGGACCA	0.453													17	35					3.62473e-10	5.01886e-09	0.000229342	1	0
CCDC62	84660	broad.mit.edu	37	12	123285855	123285855	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:123285855G>T	uc001udc.2	+	9	1307	c.1162G>T	c.(1162-1164)GGG>TGG	p.G388W	CCDC62_uc010tah.1_RNA|CCDC62_uc001udf.2_Missense_Mutation_p.G388W|CCDC62_uc001ude.2_Missense_Mutation_p.G149W	NM_201435	NP_958843	Q6P9F0	CCD62_HUMAN	coiled-coil domain containing 62 isoform b	388						cytoplasm|nucleus				ovary(2)|large_intestine(1)|pancreas(1)|skin(1)	5	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.51e-06)|Epithelial(86;2.65e-05)|BRCA - Breast invasive adenocarcinoma(302;0.206)		TACTGTGTTTGGGGAGAAAAG	0.428													13	24					3.27435e-08	3.95318e-07	0.000219431	1	0
PIWIL1	9271	broad.mit.edu	37	12	130831091	130831091	+	Nonsense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr12:130831091G>T	uc001uik.2	+	5	583	c.493G>T	c.(493-495)GGA>TGA	p.G165*	PIWIL1_uc001uij.1_Nonsense_Mutation_p.G165*	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	165					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		TGCTTTTGATGGAACGATATT	0.388													19	26					2.21704e-12	3.47014e-11	0.000375601	1	0
LOC284232	284232	broad.mit.edu	37	13	19419910	19419910	+	RNA	SNP	A	C	C			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr13:19419910A>C	uc010tcj.1	-	1		c.26200T>G				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						CACTTCTTTCACGTCTTTGTT	0.328													37	63					0	0	0.000437636	0	0
LATS2	26524	broad.mit.edu	37	13	21549192	21549192	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr13:21549192G>T	uc009zzs.2	-	8	3449	c.3084C>A	c.(3082-3084)CCC>CCA	p.P1028P	LATS2_uc001unr.3_Silent_p.P1028P	NM_014572	NP_055387	Q9NRM7	LATS2_HUMAN	LATS, large tumor suppressor, homolog 2	1028	AGC-kinase C-terminal.				cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(3)|ovary(2)|breast(1)|pancreas(1)	10		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		GCTTGTTATTGGGCGAGGTGA	0.527													40	59					6.5261e-18	1.33903e-16	0.000374591	1	0
FGF9	2254	broad.mit.edu	37	13	22255252	22255252	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr13:22255252G>T	uc001uog.2	+	2	1186	c.349G>T	c.(349-351)GGG>TGG	p.G117W		NM_002010	NP_002001	P31371	FGF9_HUMAN	fibroblast growth factor 9 precursor	117					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|male gonad development|positive regulation of cell division	extracellular space	growth factor activity|heparin binding				0		all_cancers(29;1.23e-20)|all_epithelial(30;9.83e-19)|all_lung(29;9.64e-17)|Lung SC(185;0.0262)|Breast(139;0.106)		all cancers(112;3.92e-05)|Epithelial(112;0.000166)|OV - Ovarian serous cystadenocarcinoma(117;0.00314)|Lung(94;0.163)		ACTCTACCTCGGGATGAATGA	0.488													25	53					1.68575e-08	2.09924e-07	0.000184323	1	0
TRPC4	7223	broad.mit.edu	37	13	38211448	38211448	+	Silent	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr13:38211448G>A	uc001uws.2	-	11	2761	c.2526C>T	c.(2524-2526)ATC>ATT	p.I842I	TRPC4_uc010abv.2_Silent_p.I422I|TRPC4_uc001uwt.2_Intron|TRPC4_uc010tey.1_Intron|TRPC4_uc010abw.2_Silent_p.I669I|TRPC4_uc010abx.2_Silent_p.I847I|TRPC4_uc010aby.2_Intron	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	842	Binds to ITPR1, ITPR2 and ITPR3.|Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		CAAAGTTTTTGATATCGGTCA	0.428													21	125					0	0	0.000175454	0	0
UFM1	51569	broad.mit.edu	37	13	38924142	38924142	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr13:38924142G>T	uc001uwu.2	+	2	124	c.9G>T	c.(7-9)AAG>AAT	p.K3N	UFM1_uc010abz.2_Missense_Mutation_p.K3N|UFM1_uc010aca.2_Missense_Mutation_p.K3N	NM_016617	NP_057701	P61960	UFM1_HUMAN	ubiquitin-fold modifier 1 precursor	3					protein ufmylation	cytoplasm|nucleus	protein binding				0		Lung NSC(96;3.18e-06)|Prostate(109;0.00314)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;1.05e-08)|Epithelial(112;1.44e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000855)|BRCA - Breast invasive adenocarcinoma(63;0.00342)|GBM - Glioblastoma multiforme(144;0.0132)		TCAGGTCGAAGGTTTCCTTTA	0.577													36	250					3.33393e-15	6.14064e-14	0.000953801	1	0
FREM2	341640	broad.mit.edu	37	13	39266448	39266448	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr13:39266448C>A	uc001uwv.2	+	1	5276	c.4967C>A	c.(4966-4968)CCC>CAC	p.P1656H		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1656	Extracellular (Potential).|CSPG 12.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		AACAGTGTCCCCCAAATCGCA	0.483													30	393					3.57733e-08	4.30584e-07	0.000279167	1	0
C13orf23	80209	broad.mit.edu	37	13	39587682	39587682	+	Silent	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr13:39587682C>T	uc001uwy.2	-	11	2580	c.1707G>A	c.(1705-1707)ACG>ACA	p.T569T	C13orf23_uc001uwz.2_Silent_p.T547T	NM_025138	NP_079414	Q86XN7	CM023_HUMAN	hypothetical protein LOC80209 isoform 1	569	Ser-rich.									ovary(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)	5		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;3.7e-08)|Epithelial(112;4.28e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00114)|BRCA - Breast invasive adenocarcinoma(63;0.00366)|GBM - Glioblastoma multiforme(144;0.0146)		CTGGCACTGACGTGGAAGCTG	0.572													24	270					0	0	0.000375601	0	0
HNRNPA1L2	144983	broad.mit.edu	37	13	53217458	53217458	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr13:53217458G>T	uc001vgx.1	+	7	1904	c.831G>T	c.(829-831)AAG>AAT	p.K277N	HNRNPA1L2_uc001vgy.1_Missense_Mutation_p.K277N|HNRNPA1L2_uc001vgz.1_Missense_Mutation_p.K277N	NM_001011724	NP_001011724	Q32P51	RA1L2_HUMAN	heterogeneous nuclear ribonucleoprotein A1-like	277	Nuclear targeting sequence (By similarity).|Gly-rich.				mRNA processing|mRNA transport|RNA splicing	cytoplasm|spliceosomal complex	nucleotide binding|RNA binding				0						GACCCATGAAGGGAGGAAATT	0.363													31	15					9.9998e-32	2.91171e-30	0.000589545	1	0
UBAC2	337867	broad.mit.edu	37	13	99896180	99896180	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr13:99896180G>T	uc001voa.3	+	3	738	c.254G>T	c.(253-255)AGA>ATA	p.R85I	UBAC2_uc010tiu.1_Missense_Mutation_p.R107I|UBAC2_uc001vob.3_Intron|UBAC2_uc010tiv.1_RNA|UBAC2_uc001vod.2_5'UTR|UBAC2_uc001voc.2_Intron|UBAC2_uc010tiw.1_RNA	NM_001144072	NP_001137544	Q8NBM4	UBAC2_HUMAN	UBA domain containing 2 isoform 1	85	Extracellular (Potential).					integral to membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					ATATTTGAAAGAAGATATGGA	0.274													3	1					6.4e-05	0.000605002	6.4e-05	1	0
OR4M1	441670	broad.mit.edu	37	14	20248596	20248596	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr14:20248596C>A	uc010tku.1	+	1	115	c.115C>A	c.(115-117)CTA>ATA	p.L39I		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	39	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTTGTTCATCCTACCAGGAAA	0.423													69	106					2.92363e-43	9.33677e-42	0.000781405	1	0
PCK2	5106	broad.mit.edu	37	14	24568320	24568320	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr14:24568320C>A	uc001wlt.2	+	5	859	c.727C>A	c.(727-729)CAG>AAG	p.Q243K	NRL_uc001wlq.2_Intron|PCK2_uc001wlr.1_Missense_Mutation_p.Q255K|PCK2_uc001wls.2_Missense_Mutation_p.Q243K|PCK2_uc010tnw.1_Missense_Mutation_p.Q109K|PCK2_uc010ald.2_Missense_Mutation_p.Q95K|PCK2_uc010ale.2_Intron|PCK2_uc010tnx.1_Missense_Mutation_p.Q109K|PCK2_uc001wlu.3_Missense_Mutation_p.Q109K	NM_004563	NP_004554	Q16822	PCKGM_HUMAN	mitochondrial phosphoenolpyruvate carboxykinase	243					gluconeogenesis	mitochondrial matrix	GTP binding|metal ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.0184)		CGTGCCCGACCAGCGGGAGAT	0.642													10	36					2.74318e-10	3.85212e-09	0.000442599	1	0
SYNE2	23224	broad.mit.edu	37	14	64443297	64443297	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr14:64443297T>A	uc001xgm.2	+	12	1375	c.1145T>A	c.(1144-1146)ATA>AAA	p.I382K	SYNE2_uc001xgl.2_Missense_Mutation_p.I382K	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	382	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GCATGGAAAATAAAGCTAAAT	0.358													15	115					0	0	0.000958276	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634712	70634712	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr14:70634712G>A	uc001xly.2	-	2	1182	c.428C>T	c.(427-429)TCC>TTC	p.S143F	SLC8A3_uc001xlw.2_Missense_Mutation_p.S143F|SLC8A3_uc001xlx.2_Missense_Mutation_p.S143F|SLC8A3_uc001xlz.2_Missense_Mutation_p.S143F|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	143	Cytoplasmic (Potential).|Alpha-1.				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		AGGAGCAGAGGAACCCAGGGC	0.498													11	23					0	0	0.000151284	0	0
LTBP2	4053	broad.mit.edu	37	14	74988710	74988710	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr14:74988710C>T	uc001xqa.2	-	17	3079	c.2692G>A	c.(2692-2694)GGA>AGA	p.G898R		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	898	EGF-like 5; calcium-binding (Potential).|Cys-rich.				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CGCCCTTTTCCCTTGCAGGGG	0.617													5	8					0	0	3.59834e-05	0	0
MLH3	27030	broad.mit.edu	37	14	75514030	75514030	+	Nonsense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr14:75514030C>A	uc001xrd.1	-	2	2545	c.2329G>T	c.(2329-2331)GGA>TGA	p.G777*	MLH3_uc001xre.1_Nonsense_Mutation_p.G777*|MLH3_uc010tuy.1_RNA	NM_001040108	NP_001035197	Q9UHC1	MLH3_HUMAN	mutL homolog 3 isoform 1	777					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00688)		GTAGTGACTCCATTACTTTCC	0.403								MMR					39	65					1.57019e-19	3.47372e-18	0.000319135	1	0
FOXN3	1112	broad.mit.edu	37	14	89628893	89628893	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr14:89628893G>T	uc001xxo.3	-	7	1475	c.1338C>A	c.(1336-1338)CCC>CCA	p.P446P	FOXN3_uc001xxn.3_Silent_p.P424P|FOXN3_uc010atk.2_Silent_p.P424P	NM_001085471	NP_001078940	O00409	FOXN3_HUMAN	checkpoint suppressor 1 isoform 1	446					DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(2)|ovary(1)	3						CATCGCTCTCGGGGGGCTTTT	0.582													12	22					9.31168e-06	9.35895e-05	0.000151284	1	0
EIF5	1983	broad.mit.edu	37	14	103807359	103807359	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr14:103807359G>T	uc001ymq.2	+	12	1788	c.1266G>T	c.(1264-1266)AAG>AAT	p.K422N	EIF5_uc001ymr.2_Missense_Mutation_p.K422N|EIF5_uc001yms.2_Missense_Mutation_p.K422N|EIF5_uc001ymt.2_Missense_Mutation_p.K422N|EIF5_uc001ymu.2_Missense_Mutation_p.K422N	NM_001969	NP_001960	P55010	IF5_HUMAN	eukaryotic translation initiation factor 5	422					regulation of translational initiation|RNA metabolic process	cytosol	GTP binding|GTPase activity|translation initiation factor activity			pancreas(1)|breast(1)|skin(1)	3		Melanoma(154;0.155)	Epithelial(46;0.182)			CAGACAACAAGGATGACGACA	0.393													38	64					1.23103e-26	3.33895e-25	0.000680045	1	0
ASPG	374569	broad.mit.edu	37	14	104559928	104559928	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr14:104559928C>A	uc001yoq.1	+	3	352	c.292C>A	c.(292-294)CAG>AAG	p.Q98K	ASPG_uc001yoo.1_Missense_Mutation_p.Q126K|ASPG_uc001yop.1_Missense_Mutation_p.Q98K|ASPG_uc001yor.1_Missense_Mutation_p.Q98K	NM_001080464	NP_001073933	Q86U10	LPP60_HUMAN	60 kDa lysophospholipase	98	Asparaginase.				lipid catabolic process		1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity				0						TTGCCTTGCCCAGACCATCAA	0.343													17	45					5.35267e-07	5.90433e-06	0.000958276	1	0
ADAM6	8755	broad.mit.edu	37	14	106667806	106667806	+	RNA	SNP	T	G	G			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr14:106667806T>G	uc010tyt.1	-	877		c.22059A>C								Parts of antibodies, mostly variable regions.												0						ATCCAGAGGCTGCACAGGAGA	0.577													18	44					0	0	0.000566183	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22864188	22864188	+	Silent	SNP	T	C	C			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr15:22864188T>C	uc001yur.3	+	16	2276	c.2146T>C	c.(2146-2148)TTG>CTG	p.L716L	TUBGCP5_uc001yuq.2_Silent_p.L716L	NM_052903	NP_443135	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	716					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			skin(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		TCCATTCAGGTTGGTAGAATA	0.363													22	31					0	0	0.00047179	0	0
HERC2	8924	broad.mit.edu	37	15	28538062	28538062	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr15:28538062C>A	uc001zbj.2	-	4	400	c.294G>T	c.(292-294)CTG>CTT	p.L98L	HERC2_uc001zbl.1_5'UTR	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	98					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CCCAGCTGTCCAGAATTGACT	0.418													14	28					1.45105e-14	2.56525e-13	0.00074312	1	0
RYR3	6263	broad.mit.edu	37	15	34078059	34078059	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr15:34078059C>A	uc001zhi.2	+	66	9535	c.9465C>A	c.(9463-9465)CCC>CCA	p.P3155P	RYR3_uc010bar.2_Silent_p.P3155P	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3155					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ACCTGCCCCCCAGCACAGGGC	0.557													43	73					1.41504e-22	3.43775e-21	0.000589545	1	0
PLA2G4D	283748	broad.mit.edu	37	15	42362987	42362987	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr15:42362987G>T	uc001zox.2	-	18	2066	c.1971C>A	c.(1969-1971)CCC>CCA	p.P657P		NM_178034	NP_828848	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD	657	PLA2c.				phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			large_intestine(1)|skin(1)	2		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		GGAACATGGAGGGAGAGCTGG	0.642													6	6					8.12818e-05	0.000757356	8.12818e-05	1	0
TRIM69	140691	broad.mit.edu	37	15	45050916	45050916	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr15:45050916G>T	uc001zuf.2	+	5	1572	c.677G>T	c.(676-678)CGG>CTG	p.R226L	TRIM69_uc001zui.1_Missense_Mutation_p.R22L|TRIM69_uc010bdy.1_Missense_Mutation_p.R22L|TRIM69_uc001zug.1_Missense_Mutation_p.R226L|TRIM69_uc001zuh.1_Missense_Mutation_p.R67L	NM_182985	NP_892030	Q86WT6	TRI69_HUMAN	tripartite motif-containing 69 isoform a	226	Potential.				apoptosis	nuclear speck	zinc ion binding				0		all_cancers(109;2.47e-13)|all_epithelial(112;2.84e-11)|Lung NSC(122;2.23e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;5.5e-19)|GBM - Glioblastoma multiforme(94;1.07e-06)|Colorectal(105;0.138)|COAD - Colon adenocarcinoma(120;0.141)		ACTGAGCTCCGGGAAGAGGGG	0.468													20	31					5.35267e-07	5.90433e-06	0.000958276	1	0
ANKDD1A	348094	broad.mit.edu	37	15	65208100	65208100	+	Splice_Site	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr15:65208100G>A	uc002aoa.2	+	2	167	c.138_splice	c.e2+1	p.H46_splice	ANKDD1A_uc002anx.1_Splice_Site_p.H46_splice|ANKDD1A_uc002any.2_Splice_Site|ANKDD1A_uc002anz.2_Intron|ANKDD1A_uc002aob.2_Splice_Site_p.H16_splice	NM_182703	NP_874362	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A						signal transduction					ovary(1)	1						CAGAAACCACGTGCGTAATGA	0.552													10	17					0	0	0.000978159	0	0
IGDCC4	57722	broad.mit.edu	37	15	65693168	65693168	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr15:65693168G>T	uc002aou.1	-	5	1027	c.817C>A	c.(817-819)CCT>ACT	p.P273T		NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	273	Ig-like C2-type 3.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						GACACAAAAGGGGTGGGGTCA	0.617											OREG0023196	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	25					2.32078e-09	3.05326e-08	0.000308642	1	0
NOX5	79400	broad.mit.edu	37	15	69339775	69339775	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr15:69339775G>T	uc002ars.1	+	12	1735	c.1715G>T	c.(1714-1716)GGG>GTG	p.G572V	NOX5_uc002arp.1_Missense_Mutation_p.G554V|NOX5_uc002arq.1_Missense_Mutation_p.G526V|NOX5_uc010bid.1_Missense_Mutation_p.G537V|NOX5_uc002arr.1_Missense_Mutation_p.G544V|NOX5_uc010bie.1_Missense_Mutation_p.G372V|NOX5_uc010bif.1_RNA	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	572	FAD-binding FR-type.|Cytoplasmic (Potential).				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						GGGCCTTATGGGACCCCCACC	0.597													11	43					1.08611e-07	1.2576e-06	0.000978159	1	0
CSPG4	1464	broad.mit.edu	37	15	75981198	75981198	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr15:75981198C>A	uc002baw.2	-	3	2301	c.2208G>T	c.(2206-2208)GTG>GTT	p.V736V		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	736	CSPG 3.|Extracellular (Potential).|Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).|Interaction with COL6A2 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						GGCCCTGCTCCACATCCCGCT	0.667													14	22					2.32078e-09	3.05326e-08	0.000308642	1	0
SCAPER	49855	broad.mit.edu	37	15	76668513	76668513	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr15:76668513G>T	uc002bby.2	-	28	3904	c.3845C>A	c.(3844-3846)CCA>CAA	p.P1282Q	SCAPER_uc010bkr.2_Intron|SCAPER_uc002bbx.2_Missense_Mutation_p.P1036Q	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	1281						endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						CTGGTTATCTGGGTGGTTGAC	0.557													13	36					4.93089e-13	8.10221e-12	0.000219431	1	0
ADAMTSL3	57188	broad.mit.edu	37	15	84694036	84694036	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr15:84694036G>A	uc002bjz.3	+	27	4728	c.4504G>A	c.(4504-4506)GGA>AGA	p.G1502R	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.G1502R|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.G1502R	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1502	TSP type-1 9.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			TTGCGGTGAAGGATACCACAG	0.522													13	27					0	0	0.000958276	0	0
FURIN	5045	broad.mit.edu	37	15	91419735	91419735	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr15:91419735G>T	uc002bpu.1	+	4	536	c.320G>T	c.(319-321)CGG>CTG	p.R107L		NM_002569	NP_002560	P09958	FURIN_HUMAN	furin preproprotein	107		Cleavage, first; by autolysis.			cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			central_nervous_system(4)|lung(2)|breast(1)	7	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			CGGACTAAACGGGACGTGTAC	0.617													48	109					7.47603e-22	1.78344e-20	0.000781405	1	0
FURIN	5045	broad.mit.edu	37	15	91420142	91420142	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr15:91420142G>T	uc002bpu.1	+	5	605	c.389G>T	c.(388-390)CGG>CTG	p.R130L		NM_002569	NP_002560	P09958	FURIN_HUMAN	furin preproprotein	130					cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			central_nervous_system(4)|lung(2)|breast(1)	7	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			GTCACTCAGCGGGACCTGAAT	0.567													10	258					0.000673444	0.00587409	0.000673444	1	0
PRC1	9055	broad.mit.edu	37	15	91523549	91523550	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr15:91523549_91523550CG>AT	uc002bqm.2	-	7	1049_1050	c.892_893CG>AT	c.(892-894)CGA>ATA	p.R298I	PRC1_uc002bqn.2_Missense_Mutation_p.R298I|PRC1_uc002bqo.2_Missense_Mutation_p.R298I|PRC1_uc010uqs.1_Missense_Mutation_p.R257I	NM_003981	NP_003972	O43663	PRC1_HUMAN	protein regulator of cytokinesis 1 isoform 1	298	Potential.|Dimerization.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			ovary(1)|skin(1)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					CAGCTCCACTCGAATTGCCTCA	0.446													8	393					0	0	6.4e-05	0	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr15:102515299G>A	uc002cdi.2	+	9	1943	c.523G>A	c.(523-525)GGC>AGC	p.G175S	WASH3P_uc002cdl.2_Missense_Mutation_p.G175S|WASH3P_uc002cdk.2_RNA|WASH3P_uc002cdp.2_Missense_Mutation_p.G175S|WASH3P_uc010bpo.2_RNA|WASH3P_uc002cdq.2_RNA|WASH3P_uc002cdr.2_RNA	NR_003659				RecName: Full=WAS protein family homolog 2; AltName: Full=Protein FAM39B; AltName: Full=CXYorf1-like protein on chromosome 2;												0						TGGGGGCATCGGCAAGGCCAA	0.652													4	18					0	0	0.000602214	0	0
CCDC78	124093	broad.mit.edu	37	16	773117	773117	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr16:773117C>A	uc002cjg.2	-	12	1284	c.1178G>T	c.(1177-1179)CGG>CTG	p.R393L	CCDC78_uc002cjf.2_Missense_Mutation_p.R242L|CCDC78_uc002cji.3_3'UTR|CCDC78_uc002cjj.3_3'UTR|CCDC78_uc002cjh.2_Missense_Mutation_p.R152L	NM_001031737	NP_001026907	A2IDD5	CCD78_HUMAN	coiled-coil domain containing 78	393										central_nervous_system(1)	1		Hepatocellular(780;0.0218)				GGAGAAGTCCCGGAGCTTCTG	0.642													4	24					0.000602214	0.00527604	0.000602214	1	0
FAHD1	81889	broad.mit.edu	37	16	1877845	1877845	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr16:1877845C>A	uc002cnc.1	+	1	621	c.615C>A	c.(613-615)ATC>ATA	p.I205I	HAGH_uc002cmz.2_5'Flank|HAGH_uc002cna.2_5'Flank|HAGH_uc010uvp.1_5'Flank|HAGH_uc002cnb.1_5'Flank|HAGH_uc010bry.1_5'Flank|FAHD1_uc002cnd.2_Silent_p.I205I|FAHD1_uc010brz.2_Silent_p.I205I	NM_031208	NP_112485	Q6P587	FAHD1_HUMAN	fumarylacetoacetate hydrolase domain containing	205						mitochondrion	hydrolase activity|metal ion binding|protein binding				0						ACGATGAGATCGAGGCTGGCA	0.423													21	39					4.72057e-08	5.59685e-07	0.000586117	1	0
PRSS21	10942	broad.mit.edu	37	16	2868943	2868943	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr16:2868943G>T	uc002crt.2	+	4	629	c.523G>T	c.(523-525)GGC>TGC	p.G175C	PRSS21_uc002crs.2_Missense_Mutation_p.G173C|PRSS21_uc002crr.2_Missense_Mutation_p.G175C	NM_006799	NP_006790	Q9Y6M0	TEST_HUMAN	testisin isoform 1	175	Peptidase S1.				proteolysis	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	serine-type endopeptidase activity			ovary(1)|skin(1)	2						CTGGGTGACTGGCTGGGGGTA	0.557													16	25					6.49762e-13	1.04596e-11	0.00074312	1	0
NLRC3	197358	broad.mit.edu	37	16	3614431	3614431	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr16:3614431C>A	uc010btn.2	-	5	918	c.507G>T	c.(505-507)AAG>AAT	p.K169N		NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	169	NACHT.				I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						GCGAGAAGTCCTTGCCGACCT	0.657													15	21					3.10358e-05	0.00030123	0.000295444	1	0
CREBBP	1387	broad.mit.edu	37	16	3778993	3778993	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr16:3778993C>A	uc002cvv.2	-	31	6259	c.6055G>T	c.(6055-6057)GGG>TGG	p.G2019W	CREBBP_uc002cvw.2_Missense_Mutation_p.G1981W	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	2019					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGCCACTGCCCGGGAGGCATG	0.726			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				5	5					8.12818e-05	0.000757356	8.12818e-05	1	0
GRIN2A	2903	broad.mit.edu	37	16	9858428	9858428	+	Silent	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr16:9858428G>A	uc002czo.3	-	13	3521	c.2973C>T	c.(2971-2973)TCC>TCT	p.S991S	GRIN2A_uc010uym.1_Silent_p.S991S|GRIN2A_uc010uyn.1_Silent_p.S834S|GRIN2A_uc002czr.3_Silent_p.S991S	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	991	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGTTAGGGTTGGACTCATTGA	0.493													11	47					0	0	0.000151284	0	0
NOMO1	23420	broad.mit.edu	37	16	14970250	14970250	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr16:14970250G>T	uc002dcv.2	+	21	2457	c.2391G>T	c.(2389-2391)GGG>GGT	p.G797G		NM_014287	NP_055102	Q15155	NOMO1_HUMAN	nodal modulator 1 precursor	797	Extracellular (Potential).					integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			ovary(1)	1						AGATCCATGGGAAGGCAGGCC	0.522													34	53					9.62906e-15	1.72539e-13	0.000228196	1	0
MYH11	4629	broad.mit.edu	37	16	15841937	15841937	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr16:15841937G>T	uc002ddy.2	-	17	2254	c.2147C>A	c.(2146-2148)CCC>CAC	p.P716H	MYH11_uc002ddv.2_Missense_Mutation_p.P723H|MYH11_uc002ddw.2_Missense_Mutation_p.P716H|MYH11_uc002ddx.2_Missense_Mutation_p.P723H|MYH11_uc010bvg.2_Missense_Mutation_p.P548H	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	716	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						GATCCGGTTGGGGAAGCCCTG	0.632			T	CBFB	AML								9	26					3.86212e-05	0.00036853	0.000673444	1	0
TMC7	79905	broad.mit.edu	37	16	19020565	19020565	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr16:19020565C>A	uc002dfq.2	+	2	269	c.139C>A	c.(139-141)CGG>AGG	p.R47R	TMC7_uc010vao.1_Silent_p.R47R|TMC7_uc002dfp.2_Silent_p.R47R|TMC7_uc010vap.1_5'UTR	NM_024847	NP_079123	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7 isoform a	47	Extracellular (Potential).					integral to membrane				skin(2)|ovary(1)	3						GCCAAGCTACCGGTCCATTGC	0.488													30	33					7.26314e-15	1.30737e-13	0.000184323	1	0
ACSM3	6296	broad.mit.edu	37	16	20781506	20781506	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr16:20781506C>A	uc002dhr.2	+	2	337	c.150C>A	c.(148-150)TTC>TTA	p.F50L	ACSM3_uc002dhq.2_Missense_Mutation_p.F50L|ACSM3_uc010vba.1_Missense_Mutation_p.F42L	NM_005622	NP_005613	Q53FZ2	ACSM3_HUMAN	SA hypertension-associated homolog isoform 1	50					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			ovary(1)	1						AACAGGACTTCAAACTGGGGA	0.443													26	24					7.68411e-24	1.98883e-22	0.000227799	1	0
RRN3P1	730092	broad.mit.edu	37	16	21817457	21817457	+	Silent	SNP	G	A	A	rs150520281	by1000genomes	TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr16:21817457G>A	uc010vbl.1	-	7	603	c.106C>T	c.(106-108)CTG>TTG	p.L36L	uc002diq.3_Intron	NR_003370				SubName: Full=Putative uncharacterized protein ENSP00000219758;												0						CTTACATCCAGCTTGAGTAGT	0.254													4	26					0	0	0.00024832	0	0
CORO1A	11151	broad.mit.edu	37	16	30196587	30196587	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr16:30196587C>A	uc002dww.2	+	2	179	c.57C>A	c.(55-57)GCC>GCA	p.A19A	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|CORO1A_uc010vej.1_Silent_p.A19A|CORO1A_uc010bzq.2_Silent_p.A19A|CORO1A_uc010bzr.2_Silent_p.A19A|CORO1A_uc002dwx.2_5'UTR|CORO1A_uc002dwy.1_5'Flank	NM_007074	NP_009005	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	19	WD 1.				cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity				0						GACAGCCGGCCAAGGCCGACC	0.582													9	36					1.12685e-05	0.000112119	0.000274275	1	0
ITGAX	3687	broad.mit.edu	37	16	31373991	31373991	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr16:31373991C>A	uc002ebu.1	+	12	1343	c.1276C>A	c.(1276-1278)CGC>AGC	p.R426S	ITGAX_uc002ebt.2_Missense_Mutation_p.R426S|ITGAX_uc010vfk.1_Missense_Mutation_p.R76S	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	426	FG-GAP 4.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GGGGGCCCCCCGCTACCAGCA	0.657													7	6					8.12818e-05	0.000757356	8.12818e-05	1	0
DNAJA2	10294	broad.mit.edu	37	16	46993208	46993208	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr16:46993208G>C	uc002eeo.2	-	7	1040	c.898C>G	c.(898-900)CCT>GCT	p.P300A	DNAJA2_uc002eep.2_Missense_Mutation_p.P217A	NM_005880	NP_005871	O60884	DNJA2_HUMAN	DnaJ subfamily A member 2	300					positive regulation of cell proliferation|protein folding|response to heat	membrane	ATP binding|heat shock protein binding|metal ion binding|unfolded protein binding			lung(1)	1		all_cancers(37;0.00125)|all_lung(18;0.00338)|all_epithelial(9;0.00358)|Lung NSC(13;0.0309)|Breast(268;0.116)				ACTTTGCCAGGGGGGTATTTC	0.333													3	93					0	0	0.00024832	0	0
WWP2	11060	broad.mit.edu	37	16	69875994	69875994	+	Silent	SNP	C	A	A	rs150363676		TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr16:69875994C>A	uc002exu.1	+	7	635	c.546C>A	c.(544-546)CCC>CCA	p.P182P	WWP2_uc002ext.2_Silent_p.P182P|WWP2_uc002exv.1_Silent_p.P182P|WWP2_uc010vlm.1_Silent_p.P66P	NM_007014	NP_008945	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase	182					entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			lung(3)|ovary(1)|breast(1)|skin(1)	6						ACCAGCCCCCCAGCACAAACT	0.498													10	10					1.08611e-07	1.2576e-06	0.000978159	1	0
BCAR1	9564	broad.mit.edu	37	16	75268985	75268985	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr16:75268985G>T	uc002fdv.2	-	5	1935	c.1812C>A	c.(1810-1812)CTC>CTA	p.L604L	BCAR1_uc002fdt.2_Silent_p.L57L|BCAR1_uc002fdu.2_Silent_p.L394L|BCAR1_uc010cgu.2_Silent_p.L593L|BCAR1_uc010vna.1_Silent_p.L602L|BCAR1_uc010vnb.1_Silent_p.L650L|BCAR1_uc002fdw.2_Silent_p.L604L|BCAR1_uc010vnc.1_Silent_p.L456L|BCAR1_uc010vnd.1_Silent_p.L622L|BCAR1_uc002fdx.2_Silent_p.L622L	NM_014567	NP_055382	P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	604	Ser-rich.				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			central_nervous_system(5)|breast(2)|prostate(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.169)		TCCGTCTGAAGAGCAGTGAGG	0.687													10	18					1.61879e-10	2.3059e-09	0.00010058	1	0
ADAMTS18	170692	broad.mit.edu	37	16	77397761	77397761	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr16:77397761C>A	uc002ffc.3	-	6	1413	c.994G>T	c.(994-996)GGG>TGG	p.G332W	ADAMTS18_uc010chc.1_5'UTR|ADAMTS18_uc002ffe.1_Missense_Mutation_p.G28W|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	332	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						CCAATAGTCCCATCTTTAAAT	0.373													15	28					1.02788e-11	1.5536e-10	0.000566183	1	0
VAT1L	57687	broad.mit.edu	37	16	77896747	77896747	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr16:77896747C>A	uc002ffg.1	+	4	779	c.682C>A	c.(682-684)CTC>ATC	p.L228I		NM_020927	NP_065978	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport protein 1 homolog (T.	228							oxidoreductase activity|zinc ion binding			central_nervous_system(1)	1						TGTGACCCACCTCTTTGACAG	0.473													26	69					1.42536e-11	2.12196e-10	0.000720815	1	0
ZZEF1	23140	broad.mit.edu	37	17	3947527	3947527	+	Nonsense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr17:3947527C>A	uc002fxe.2	-	38	6221	c.6157G>T	c.(6157-6159)GGA>TGA	p.G2053*	ZZEF1_uc002fxh.2_Nonsense_Mutation_p.G367*|ZZEF1_uc002fxi.2_Nonsense_Mutation_p.G288*|ZZEF1_uc002fxj.1_Nonsense_Mutation_p.G666*	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	2053							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CCTGGAAGTCCTGTAGGTGGG	0.423													28	11					3.03874e-20	6.91575e-19	0.00058488	1	0
DNAH2	146754	broad.mit.edu	37	17	7722560	7722560	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr17:7722560C>A	uc002giu.1	+	71	10863	c.10849C>A	c.(10849-10851)CTG>ATG	p.L3617M	DNAH2_uc010cnm.1_Missense_Mutation_p.L555M	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	3617					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GGCATCAATCCTGTTCTTCGT	0.582													27	9					8.88839e-20	1.99989e-18	0.000339439	1	0
MYH10	4628	broad.mit.edu	37	17	8408088	8408088	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr17:8408088A>C	uc002gll.2	-	26	3526	c.3430T>G	c.(3430-3432)TTG>GTG	p.L1144V	MYH10_uc002glm.2_Missense_Mutation_p.L1175V|MYH10_uc010cnx.2_Missense_Mutation_p.L1153V	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1144	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						TCCTCACTCAAGTCCCTTTTC	0.527													31	28					0	0	0.000409698	0	0
DNAH9	1770	broad.mit.edu	37	17	11593391	11593391	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr17:11593391G>A	uc002gne.2	+	20	4320	c.4252G>A	c.(4252-4254)GAT>AAT	p.D1418N	DNAH9_uc010coo.2_Missense_Mutation_p.D712N	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1418	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CCACTATGAGGATGAGGTCCG	0.562													9	5					0	0	0.000274275	0	0
SUPT6H	6830	broad.mit.edu	37	17	27027482	27027482	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr17:27027482C>A	uc002hby.2	+	35	4848	c.4758C>A	c.(4756-4758)TCC>TCA	p.S1586S	SUPT6H_uc010crt.2_Silent_p.S1586S	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	1586					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					AGTGGGCCTCCAGCCAGTACG	0.612													26	62					4.11147e-35	1.22417e-33	0.000692331	1	0
MYO18A	399687	broad.mit.edu	37	17	27442428	27442428	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr17:27442428C>A	uc002hdt.1	-	13	2417	c.2259G>T	c.(2257-2259)GAG>GAT	p.E753D	MYO18A_uc010wbc.1_Missense_Mutation_p.E295D|MYO18A_uc002hds.2_Missense_Mutation_p.E295D|MYO18A_uc010csa.1_Missense_Mutation_p.E753D|MYO18A_uc002hdu.1_Missense_Mutation_p.E753D|MYO18A_uc010wbd.1_Missense_Mutation_p.E422D	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	753	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			CCGCCATGCCCTCAAGGCACT	0.632													16	32					7.45023e-12	1.13911e-10	0.000175454	1	0
MMP28	79148	broad.mit.edu	37	17	34097293	34097293	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr17:34097293C>T	uc002hjy.1	-	7	902	c.643G>A	c.(643-645)GAA>AAA	p.E215K	MMP28_uc002hjw.1_RNA|MMP28_uc002hjz.1_RNA	NM_024302	NP_077278	Q9H239	MMP28_HUMAN	matrix metalloproteinase 28 isoform 1	215					proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		AAGTGCGCTTCGCCGCGGCGG	0.731													5	5					0	0	0.000602214	0	0
SRCIN1	80725	broad.mit.edu	37	17	36709048	36709048	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr17:36709048G>T	uc002hqd.2	-	12	2470	c.2245C>A	c.(2245-2247)CAC>AAC	p.H749N	SRCIN1_uc002hqf.1_Missense_Mutation_p.H621N|SRCIN1_uc002hqe.2_Missense_Mutation_p.H603N|SRCIN1_uc002hqg.2_Missense_Mutation_p.H55N	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	621	Potential.				exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0						CGGTGGTTGTGGGACACGTCT	0.632													9	56					2.80697e-09	3.64446e-08	0.000978159	1	0
KRTAP4-8	728224	broad.mit.edu	37	17	39254032	39254032	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr17:39254032G>T	uc010wfo.1	-	1	344	c.305C>A	c.(304-306)CCC>CAC	p.P102H		NM_031960	NP_114166	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4.8	102	25 X 5 AA repeats of C-C-[IKRQVHEC]- [SPRT]-[STCVQPR].|16.					keratin filament					0						acagcagctggggcggcagca	0.234													7	19					1.76689e-08	2.17295e-07	0.000442599	1	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274274	39274274	+	Silent	SNP	A	G	G			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr17:39274274A>G	uc002hvz.2	-	1	333	c.294T>C	c.(292-294)ACT>ACC	p.T98T		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	98	15.|27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ggcggcagcaAGTGGGCTGGC	0.328													3	27					0	0	0.00024832	0	0
JUP	3728	broad.mit.edu	37	17	39912104	39912104	+	Silent	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr17:39912104G>A	uc002hxq.2	-	14	2407	c.2130C>T	c.(2128-2130)CCC>CCT	p.P710P	JUP_uc010wfs.1_Intron|JUP_uc002hxr.2_Silent_p.P710P|JUP_uc002hxs.2_Silent_p.P710P	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	710					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		GCGGGTCAAGGGGCACATCGC	0.617													7	20					0	0	8.12818e-05	0	0
JUP	3728	broad.mit.edu	37	17	39919252	39919252	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr17:39919252G>T	uc002hxq.2	-	8	1757	c.1480C>A	c.(1480-1482)CAG>AAG	p.Q494K	JUP_uc010wfs.1_Intron|JUP_uc002hxr.2_Missense_Mutation_p.Q494K|JUP_uc002hxs.2_Missense_Mutation_p.Q494K	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	494	ARM 7.				adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		AGTGGCCACTGGTTGGGCTGG	0.512													10	34					1.33987e-11	2.00981e-10	0.000673444	1	0
KIAA1267	284058	broad.mit.edu	37	17	44111638	44111638	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr17:44111638C>A	uc002ikb.2	-	10	2640	c.2555G>T	c.(2554-2556)AGG>ATG	p.R852M	KIAA1267_uc002ikc.2_Missense_Mutation_p.R852M|KIAA1267_uc002ikd.2_Missense_Mutation_p.R852M|KIAA1267_uc010dav.2_Missense_Mutation_p.R851M|KIAA1267_uc010wkb.1_Missense_Mutation_p.R183M|KIAA1267_uc010wkc.1_Missense_Mutation_p.R120M	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	852						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				CCTTCTCCTCCTTACTGGCTG	0.378													12	63					1.61879e-10	2.3059e-09	0.00010058	1	0
HOXB6	3216	broad.mit.edu	37	17	46673903	46673903	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr17:46673903G>T	uc002ins.1	-	4	872	c.547C>A	c.(547-549)CTG>ATG	p.L183M	HOXB5_uc002inr.2_5'Flank|HOXB6_uc010dbh.1_Missense_Mutation_p.L183M|HOXB6_uc002int.1_3'UTR	NM_018952	NP_061825	P17509	HXB6_HUMAN	homeobox B6	183	Homeobox.				anterior/posterior axis specification, embryo	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GTCAGGCACAGGGCGTGCGCG	0.582													43	108					9.52127e-25	2.48054e-23	0.000781405	1	0
CA10	56934	broad.mit.edu	37	17	49708945	49708945	+	Nonstop_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr17:49708945C>A	uc002itw.3	-	9	1973	c.987G>T	c.(985-987)TAG>TAT	p.*329Y	CA10_uc002itu.3_Nonstop_Mutation_p.*258Y|CA10_uc002itv.3_Nonstop_Mutation_p.*335Y|CA10_uc002itx.3_Nonstop_Mutation_p.*329Y|CA10_uc002ity.3_Nonstop_Mutation_p.*329Y	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	329					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			GCTTTGTTCCCTACTTGAGGA	0.398													93	66					7.35649e-22	1.76556e-20	0.000781405	1	0
TEX2	55852	broad.mit.edu	37	17	62291306	62291306	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr17:62291306G>A	uc002jec.2	-	2	445	c.272C>T	c.(271-273)TCG>TTG	p.S91L	TEX2_uc002jed.2_Missense_Mutation_p.S91L|TEX2_uc002jee.2_Missense_Mutation_p.S91L	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	91					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		CAGGACAGGCGAGGCAGCAGG	0.592													126	90					0	0	0.000781405	0	0
FAM20A	54757	broad.mit.edu	37	17	66538276	66538276	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr17:66538276G>T	uc002jho.2	-	7	1247	c.959C>A	c.(958-960)CCA>CAA	p.P320Q	FAM20A_uc010wqp.1_Missense_Mutation_p.P182Q|PRKAR1A_uc002jhm.2_Intron|FAM20A_uc002jhn.2_Missense_Mutation_p.H23N	NM_017565	NP_060035	Q96MK3	FA20A_HUMAN	family with sequence similarity 20, member A	320						extracellular region					0	Breast(10;1.64e-13)					GCACATGTATGGACACTTGGC	0.602													6	35					3.59834e-05	0.000345859	3.59834e-05	1	0
ITGB4	3691	broad.mit.edu	37	17	73745075	73745075	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr17:73745075G>T	uc002jpg.2	+	27	3452	c.3265G>T	c.(3265-3267)GGG>TGG	p.G1089W	ITGB4_uc002jph.2_Missense_Mutation_p.G1089W|ITGB4_uc002jpi.3_Missense_Mutation_p.G1089W|ITGB4_uc002jpj.2_Missense_Mutation_p.G1089W	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	1089	Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCCTAAGTTTGGGGCCCACCT	0.637													11	33					4.3838e-07	4.8627e-06	0.000151284	1	0
RNF213	57674	broad.mit.edu	37	17	78321960	78321960	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr17:78321960G>T	uc002jyh.1	+	4	4267	c.4044G>T	c.(4042-4044)CTG>CTT	p.L1348L		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CCTACTCGCTGGGCGGGTTCG	0.602													17	49					1.56452e-12	2.47821e-11	0.000958276	1	0
C17orf101	79701	broad.mit.edu	37	17	80361888	80361888	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr17:80361888G>T	uc002keu.1	-	7	725	c.624C>A	c.(622-624)CCC>CCA	p.P208P	C17orf101_uc002ket.1_Silent_p.P208P|C17orf101_uc010dip.1_RNA	NM_024648	NP_078924	Q6PK18	CQ101_HUMAN	hypothetical protein LOC79701 isoform 1	208	Fe2OG dioxygenase.|Lumenal (Potential).					integral to membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(1)	1						AGAAGAAGGTGGGCTTGGTCA	0.622													12	18					1.61879e-10	2.3059e-09	0.00010058	1	0
NDC80	10403	broad.mit.edu	37	18	2577813	2577813	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr18:2577813C>A	uc002kli.2	+	4	430	c.248C>A	c.(247-249)CCG>CAG	p.P83Q		NM_006101	NP_006092	O14777	NDC80_HUMAN	kinetochore associated 2	83	Interaction with the N-terminus of CDCA1.|Nuclear localization.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			ovary(1)	1						ATCAAGGACCCGAGACCACTT	0.363													35	33					2.20474e-14	3.84615e-13	0.000692331	1	0
TUBB6	84617	broad.mit.edu	37	18	12325368	12325368	+	Nonsense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr18:12325368G>T	uc002kqw.2	+	4	625	c.580G>T	c.(580-582)GAG>TAG	p.E194*	TUBB6_uc002kqv.2_Nonsense_Mutation_p.E122*|TUBB6_uc010dld.2_RNA|TUBB6_uc002kqx.2_Nonsense_Mutation_p.E157*|TUBB6_uc002kqy.2_Intron	NM_032525	NP_115914	Q9BUF5	TBB6_HUMAN	tubulin, beta 6	194					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0				READ - Rectum adenocarcinoma(1;0.0649)		CCAGCTGGTGGAGAATACAGA	0.587													24	53					1.04121e-07	1.21988e-06	0.000878237	1	0
CHST9	83539	broad.mit.edu	37	18	24496499	24496499	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr18:24496499C>A	uc002kwd.2	-	5	1254	c.1056G>T	c.(1054-1056)AAG>AAT	p.K352N	C18orf16_uc002kwb.2_Intron|C18orf16_uc010xbm.1_Intron|CHST9_uc002kwc.2_Missense_Mutation_p.K267N|CHST9_uc002kwe.2_Missense_Mutation_p.K352N	NM_031422	NP_113610	Q7L1S5	CHST9_HUMAN	GalNAc-4-sulfotransferase 2	352	Lumenal (Potential).				carbohydrate biosynthetic process|glycosaminoglycan metabolic process|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	extracellular region|Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			ovary(2)|skin(1)	3	all_lung(6;0.0145)|Ovarian(20;0.124)					GTTTGCTGACCTTTTCCCAGT	0.398													39	62					7.05121e-23	1.75615e-21	0.000509022	1	0
DSG1	1828	broad.mit.edu	37	18	28923508	28923508	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr18:28923508C>T	uc002kwp.2	+	12	1995	c.1783C>T	c.(1783-1785)CAT>TAT	p.H595Y	DSG1_uc010xbp.1_5'Flank	NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	595	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			TGGAGCAATTCATTCATGGGC	0.473													25	45					0	0	0.000878237	0	0
KDSR	2531	broad.mit.edu	37	18	61011643	61011643	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr18:61011643C>A	uc010dpw.2	-	7	848	c.693G>T	c.(691-693)AAG>AAT	p.K231N	KDSR_uc010xem.1_Missense_Mutation_p.K167N	NM_002035	NP_002026	Q06136	KDSR_HUMAN	3-ketodihydrosphingosine reductase precursor	231	Cytoplasmic (Potential).				3-keto-sphinganine metabolic process	endoplasmic reticulum membrane|extracellular space|integral to membrane	3-dehydrosphinganine reductase activity|binding			skin(1)	1						GGATACTGACCTTTGTTCTGT	0.403													19	18					4.35082e-09	5.59391e-08	0.000175454	1	0
HMHA1	23526	broad.mit.edu	37	19	1084305	1084305	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:1084305G>T	uc002lqz.1	+	22	3255	c.3024G>T	c.(3022-3024)GTG>GTT	p.V1008V	HMHA1_uc010xgd.1_Silent_p.V1024V|HMHA1_uc010xge.1_Silent_p.V876V|HMHA1_uc002lra.1_Silent_p.V848V|HMHA1_uc002lrb.1_Silent_p.V891V|HMHA1_uc002lrc.1_Silent_p.V643V|HMHA1_uc002lrd.1_Silent_p.V84V|HMHA1_uc010dsd.1_Silent_p.V114V	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	1008					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGAGGCGGTGGTCTACCCGC	0.682													23	36					3.62473e-10	5.01886e-09	0.000229342	1	0
PLIN3	10226	broad.mit.edu	37	19	4839210	4839210	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:4839210C>A	uc002mbj.2	-	8	1476	c.1299G>T	c.(1297-1299)AAG>AAT	p.K433N	PLIN3_uc002mbk.2_Missense_Mutation_p.K421N|PLIN3_uc002mbl.3_Missense_Mutation_p.K432N	NM_005817	NP_005808	O60664	PLIN3_HUMAN	mannose 6 phosphate receptor binding protein 1	433					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding				0					Galsulfase(DB01279)|Idursulfase(DB01271)	CCCCCTACTTCTTCTCCTCCG	0.567													19	27					1.96292e-10	2.77613e-09	0.000175454	1	0
MUC16	94025	broad.mit.edu	37	19	9082643	9082643	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:9082643C>A	uc002mkp.2	-	1	9376	c.9172G>T	c.(9172-9174)GGG>TGG	p.G3058W		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3059	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATGGAAGGCCCAAGAAATAGT	0.488													45	54					1.03325e-14	1.84309e-13	0.000589545	1	0
NOTCH3	4854	broad.mit.edu	37	19	15276723	15276723	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:15276723G>T	uc002nan.2	-	30	5618	c.5542C>A	c.(5542-5544)CGT>AGT	p.R1848S		NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1848	Cytoplasmic (Potential).|ANK 1.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CGGGCATAACGGGCAGCCAGG	0.627													12	14					0.00010058	0.00092843	0.00010058	1	0
CYP4F12	66002	broad.mit.edu	37	19	15784502	15784502	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:15784502C>A	uc002nbl.2	+	2	224	c.163C>A	c.(163-165)CCA>ACA	p.P55T	CYP4F12_uc010xoo.1_Missense_Mutation_p.P55T|CYP4F12_uc010xop.1_Missense_Mutation_p.P55T	NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					CCCACAGCCCCCAAAACGGAA	0.587													12	57					4.36969e-10	5.98753e-09	0.000151284	1	0
NWD1	284434	broad.mit.edu	37	19	16899890	16899890	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:16899890G>T	uc002neu.3	+	13	3251	c.2829G>T	c.(2827-2829)CAG>CAT	p.Q943H	NWD1_uc002net.3_Missense_Mutation_p.Q808H|NWD1_uc002nev.3_Missense_Mutation_p.Q737H			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	943	WD 3.						ATP binding			skin(3)|ovary(2)|pancreas(2)	7						TCTCTGGCCAGGAGAAATTTA	0.473													27	29					6.32553e-13	1.02241e-11	0.000720815	1	0
USHBP1	83878	broad.mit.edu	37	19	17373625	17373625	+	Silent	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:17373625C>T	uc002nfs.1	-	4	491	c.378G>A	c.(376-378)CTG>CTA	p.L126L	USHBP1_uc002nft.1_RNA|USHBP1_uc010xpk.1_Silent_p.L62L|USHBP1_uc010eam.1_Silent_p.L54L	NM_031941	NP_114147	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	126							PDZ domain binding			ovary(1)	1						CCAGGGAGCTCAGAGTGTGCT	0.652													20	25					0	0	0.000132079	0	0
KIAA1683	80726	broad.mit.edu	37	19	18376007	18376007	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:18376007G>T	uc002nin.2	-	3	2559	c.2343C>A	c.(2341-2343)TCC>TCA	p.S781S	KIAA1683_uc010ebn.2_Silent_p.S781S|KIAA1683_uc010xqe.1_Silent_p.S735S	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	781						mitochondrion				ovary(2)	2						AGGCGTGGTTGGACACCTTGG	0.657													42	83					1.38658e-30	3.97887e-29	0.000781405	1	0
CRTC1	23373	broad.mit.edu	37	19	18885745	18885745	+	Silent	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:18885745G>A	uc002nkb.3	+	12	1549	c.1461G>A	c.(1459-1461)GCG>GCA	p.A487A	CRTC1_uc010ebv.2_Silent_p.A503A|CRTC1_uc010ebw.2_Intron|CRTC1_uc002nkc.3_Intron	NM_015321	NP_056136	Q6UUV9	CRTC1_HUMAN	mucoepidermoid carcinoma translocated 1 isoform	487					interspecies interaction between organisms|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	cAMP response element binding protein binding|protein binding		CRTC1/MAML2(516)	salivary_gland(474)|lung(35)|thyroid(4)|breast(3)|skin(2)|ovary(1)	519						TTGGGGACGCGTACTATGAGC	0.672													9	41					0	0	0.000151284	0	0
SFRS14	10147	broad.mit.edu	37	19	19106039	19106039	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:19106039C>A	uc002nkx.2	-	9	3188	c.3042G>T	c.(3040-3042)CTG>CTT	p.L1014L	SFRS14_uc002nkz.1_Silent_p.L1028L|SFRS14_uc002nla.1_Silent_p.L1014L|SFRS14_uc002nlb.2_Silent_p.L1014L|SFRS14_uc010xqk.1_Silent_p.L783L	NM_014884	NP_055699	Q8IX01	SUGP2_HUMAN	splicing factor, arginine/serine-rich 14	1014	G-patch.				mRNA processing|RNA splicing	nucleus	RNA binding				0			OV - Ovarian serous cystadenocarcinoma(5;3.05e-05)|Epithelial(12;0.00161)			TCTGGAAGCCCAGGTTCTTAT	0.612													5	19					5.9392e-07	6.51502e-06	3.59834e-05	1	0
ZNF492	57615	broad.mit.edu	37	19	22847622	22847622	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:22847622A>C	uc002nqw.3	+	4	1395	c.1151A>C	c.(1150-1152)AAG>ACG	p.K384T		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	384	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				ACTACACATAAGAGAATTCAT	0.378													5	9					0	0	0.000673444	0	0
SLC7A10	56301	broad.mit.edu	37	19	33703778	33703778	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:33703778C>T	uc002num.2	-	3	634	c.487G>A	c.(487-489)GTG>ATG	p.V163M	SLC7A10_uc002nul.2_5'Flank|SLC7A10_uc010xrq.1_Missense_Mutation_p.V136M	NM_019849	NP_062823	Q9NS82	AAA1_HUMAN	solute carrier family 7, member 10	163					blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(110;0.137)					ATGGACAGCACCCGGGAGGCT	0.632													20	43					0	0	0.000175454	0	0
FBL	2091	broad.mit.edu	37	19	40329698	40329698	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:40329698G>T	uc002omn.2	-	5	640	c.526C>A	c.(526-528)CAT>AAT	p.H176N	FBL_uc002omm.1_Missense_Mutation_p.H90N|FBL_uc002omo.2_Missense_Mutation_p.H175N|FBL_uc010egr.2_Missense_Mutation_p.H176N	NM_001436	NP_001427	P22087	FBRL_HUMAN	fibrillarin	176					rRNA processing|tRNA processing	box C/D snoRNP complex|Cajal body	methyltransferase activity|protein binding|RNA binding			ovary(1)	1	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)	Renal(1328;0.000518)|Hepatocellular(1079;0.0893)	Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)	GBM - Glioblastoma multiforme(1328;0.000826)|STAD - Stomach adenocarcinoma(1328;0.138)		TCAGAGACATGGGAGACCGTG	0.577													19	50					1.36565e-18	2.87657e-17	0.000375601	1	0
FCGBP	8857	broad.mit.edu	37	19	40412158	40412158	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:40412158G>T	uc002omp.3	-	7	3478	c.3470C>A	c.(3469-3471)CCA>CAA	p.P1157Q		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	1157	Cys-rich.|TIL 2.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CCCGGGCACTGGGAGGTCTCC	0.642													13	23					1.52009e-12	2.41749e-11	0.000308642	1	0
FCGBP	8857	broad.mit.edu	37	19	40420122	40420122	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:40420122C>A	uc002omp.3	-	6	2880	c.2872G>T	c.(2872-2874)GGG>TGG	p.G958W		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	958	VWFD 2.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGCACCTGCCCATCTGCTGCT	0.577													9	22					2.27111e-07	2.57696e-06	0.00010058	1	0
SNRPA	6626	broad.mit.edu	37	19	41269491	41269491	+	Splice_Site	SNP	G	A	A	rs112988221		TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:41269491G>A	uc002ooz.2	+	5	1136	c.601_splice	c.e5-1	p.L201_splice	SNRPA_uc002opa.2_Splice_Site_p.L151_splice	NM_004596	NP_004587	P09012	SNRPA_HUMAN	small nuclear ribonucleoprotein polypeptide A							nucleoplasm|spliceosomal complex	nucleotide binding|protein binding|RNA binding			skin(2)|ovary(1)|central_nervous_system(1)	4			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			TACCCCCGCAGCTTTCTGAGA	0.453													8	47					0	0	0.000442599	0	0
CEACAM19	56971	broad.mit.edu	37	19	45183602	45183602	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:45183602T>G	uc002ozo.3	+	5	1182	c.702T>G	c.(700-702)GAT>GAG	p.D234E	CEACAM19_uc002ozp.3_Missense_Mutation_p.D234E	NM_020219	NP_064604	Q7Z692	CEA19_HUMAN	carcinoembryonic antigen-related cell adhesion	234	Cytoplasmic (Potential).					integral to membrane					0	Lung NSC(12;0.00308)|all_lung(12;0.00806)	Prostate(69;0.0376)				CTGCTCATGATGCTGGTAAGG	0.557													75	140					0	0	0.000781405	0	0
FOXA3	3171	broad.mit.edu	37	19	46376171	46376171	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:46376171C>A	uc002pdr.2	+	2	1105	c.908C>A	c.(907-909)CCT>CAT	p.P303H		NM_004497	NP_004488	P55318	FOXA3_HUMAN	forkhead box A3	303					brain development|cellular glucose homeostasis|cellular response to starvation|chromatin modification|embryo development|endocrine pancreas development|negative regulation of cell proliferation|neural plate anterior/posterior regionalization|neuron fate specification|positive regulation of hepatocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)	1		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00453)|GBM - Glioblastoma multiforme(486;0.0518)|Epithelial(262;0.236)		TTCAACCACCCTTTCTCCATC	0.597													15	25					1.15088e-07	1.32485e-06	0.000422831	1	0
IRF2BP1	26145	broad.mit.edu	37	19	46388613	46388613	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:46388613C>A	uc002pds.1	-	1	764	c.420G>T	c.(418-420)CTG>CTT	p.L140L		NM_015649	NP_056464	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein	140					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		CCTCACGGCCCAGCCCATTGG	0.711													9	11					1.12685e-05	0.000112119	0.000274275	1	0
NTN5	126147	broad.mit.edu	37	19	49167500	49167500	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:49167500G>T	uc002pkb.2	-	4	966	c.870C>A	c.(868-870)ACC>ACA	p.T290T	SEC1_uc010xzv.1_Intron|SEC1_uc002pka.2_Intron|SEC1_uc010xzw.1_Intron|SEC1_uc010ema.2_Intron|NTN5_uc002pkc.2_Silent_p.T290T	NM_145807	NP_665806	Q8WTR8	NET5_HUMAN	netrin 5 precursor	290	Laminin EGF-like 3.					extracellular region				large_intestine(1)|pancreas(1)	2						ACTGCCCACTGGTCTGGTTGC	0.652													4	10					1.23904e-05	0.00012145	0.000602214	1	0
CD37	951	broad.mit.edu	37	19	49843549	49843549	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:49843549G>T	uc002pnd.2	+	8	931	c.810G>T	c.(808-810)CTG>CTT	p.L270L	uc002pnb.1_5'UTR|CD37_uc002pnc.2_RNA|CD37_uc002pne.2_Silent_p.L202L	NM_001774	NP_001765	P11049	CD37_HUMAN	CD37 antigen isoform A	270	Cytoplasmic (Potential).					integral to membrane					0		all_lung(116;2.81e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00088)|GBM - Glioblastoma multiforme(486;0.0443)		GCAGAAACCTGGACCACGTCT	0.622													19	27					6.44725e-10	8.80383e-09	0.000295444	1	0
MED25	81857	broad.mit.edu	37	19	50333347	50333347	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:50333347G>T	uc002ppw.1	+	7	744	c.691G>T	c.(691-693)GGG>TGG	p.G231W	MED25_uc010ybe.1_Intron|MED25_uc002ppx.1_Missense_Mutation_p.G12W	NM_030973	NP_112235	Q71SY5	MED25_HUMAN	mediator complex subunit 25	231	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm				ovary(1)	1		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00822)|GBM - Glioblastoma multiforme(134;0.0122)		GCTCTCAGTTGGGGGTGGCTC	0.622													34	65					5.71845e-15	1.04355e-13	0.00111076	1	0
ZNF577	84765	broad.mit.edu	37	19	52381728	52381728	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:52381728C>A	uc010yde.1	-	5	492	c.101G>T	c.(100-102)AGG>ATG	p.R34M	ZNF577_uc010ydd.1_RNA|ZNF577_uc002pxx.3_Missense_Mutation_p.R34M|ZNF577_uc002pxv.2_Missense_Mutation_p.R27M|ZNF577_uc002pxw.2_Missense_Mutation_p.R27M	NM_032679	NP_116068	Q9BSK1	ZN577_HUMAN	zinc finger protein 577 isoform a	34	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		CCACTCCTCCCTGGTGAAGCC	0.438													12	57					0.000151284	0.00139322	0.000151284	1	0
ZNF616	90317	broad.mit.edu	37	19	52618410	52618410	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:52618410G>T	uc002pym.2	-	4	2290	c.2007C>A	c.(2005-2007)ACC>ACA	p.T669T	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	669	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		TCCGTTTAAAGGTTTTGCCAC	0.408													35	54					2.20474e-14	3.84615e-13	0.000692331	1	0
LAIR1	3903	broad.mit.edu	37	19	54872569	54872569	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:54872569G>T	uc002qfk.1	-	3	628	c.318C>A	c.(316-318)CCC>CCA	p.P106P	LAIR1_uc002qfl.1_Silent_p.P106P|LAIR1_uc002qfm.1_Silent_p.P105P|LAIR1_uc002qfn.1_Silent_p.P105P|LAIR1_uc010yex.1_Silent_p.P99P|LAIR1_uc002qfo.2_Silent_p.P88P	NM_002287	NP_002278	Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like	106	Extracellular (Potential).|Ig-like C2-type.					integral to membrane|plasma membrane	protein binding|receptor activity			ovary(4)	4	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		ACCATTTAGGGGGCTTATAAT	0.542													38	57					2.75727e-19	5.96656e-18	0.000953801	1	0
LILRA2	11027	broad.mit.edu	37	19	55086037	55086037	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:55086037C>A	uc002qgg.3	+	3	429	c.340C>A	c.(340-342)CTG>ATG	p.L114M	LILRA2_uc010ern.2_Missense_Mutation_p.L114M|LILRA2_uc002qgf.2_Missense_Mutation_p.L114M|LILRA2_uc010yfe.1_Missense_Mutation_p.L114M|LILRA2_uc010yff.1_Missense_Mutation_p.L102M|LILRA2_uc010ero.2_Missense_Mutation_p.L102M|LILRA2_uc010yfg.1_Missense_Mutation_p.L114M	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	114	Extracellular (Potential).				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		CCCCCTGGAGCTGGTGGTGAC	0.602													6	33					1.26484e-09	1.69216e-08	0.000157383	1	0
LILRA2	11027	broad.mit.edu	37	19	55098720	55098720	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:55098720G>T	uc002qgg.3	+	8	1448	c.1359G>T	c.(1357-1359)ATG>ATT	p.M453I	LILRA2_uc010ern.2_3'UTR|LILRA2_uc002qgf.2_Missense_Mutation_p.M436I|LILRA2_uc010ero.2_Missense_Mutation_p.M424I|LILRA2_uc010yfg.1_Intron	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	453	Helical; (Potential).				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		TCATCCGCATGGGTGTGGCTG	0.582													19	32					2.21704e-12	3.47014e-11	0.000375601	1	0
NLRP2	55655	broad.mit.edu	37	19	55494486	55494486	+	Missense_Mutation	SNP	G	T	T	rs149186407		TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:55494486G>T	uc002qij.2	+	6	1506	c.1420G>T	c.(1420-1422)GGG>TGG	p.G474W	NLRP2_uc010yfp.1_Missense_Mutation_p.G451W|NLRP2_uc010esn.2_Missense_Mutation_p.G450W|NLRP2_uc010eso.2_Missense_Mutation_p.G471W|NLRP2_uc010esp.2_Missense_Mutation_p.G452W	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	474	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GGAAAGGCTCGGGGTGCAGGA	0.662													26	45					5.45727e-16	1.02908e-14	0.000227799	1	0
PEG3	5178	broad.mit.edu	37	19	57328597	57328597	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:57328597G>T	uc002qnu.2	-	7	1564	c.1213C>A	c.(1213-1215)CAC>AAC	p.H405N	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.H376N|PEG3_uc002qnv.2_Missense_Mutation_p.H405N|PEG3_uc002qnw.2_Missense_Mutation_p.H281N|PEG3_uc002qnx.2_Missense_Mutation_p.H279N|PEG3_uc010etr.2_Missense_Mutation_p.H405N	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	405					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TTTTGATCGTGAATCGAGCCC	0.488													35	71					1.836e-18	3.84686e-17	0.000692331	1	0
PEG3	5178	broad.mit.edu	37	19	57328938	57328938	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:57328938G>T	uc002qnu.2	-	7	1223	c.872C>A	c.(871-873)ACT>AAT	p.T291N	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.T262N|PEG3_uc002qnv.2_Missense_Mutation_p.T291N|PEG3_uc002qnw.2_Missense_Mutation_p.T167N|PEG3_uc002qnx.2_Missense_Mutation_p.T165N|PEG3_uc010etr.2_Missense_Mutation_p.T291N	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	291					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TTCAGGCATAGTTTTTAGACC	0.463													42	64					1.51926e-22	3.66845e-21	0.000781405	1	0
USP29	57663	broad.mit.edu	37	19	57642237	57642237	+	Nonsense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:57642237G>T	uc002qny.2	+	4	2550	c.2194G>T	c.(2194-2196)GAA>TAA	p.E732*		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	732					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGGAATGGCTGAACAGCTCCA	0.448													19	19					1.40151e-16	2.73398e-15	0.000175454	1	0
ALK	238	broad.mit.edu	37	2	29443618	29443618	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr2:29443618G>A	uc002rmy.2	-	23	4506	c.3599C>T	c.(3598-3600)GCG>GTG	p.A1200V	ALK_uc010ymo.1_Missense_Mutation_p.A132V	NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	1200	Protein kinase.|Cytoplasmic (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GTCTCCCCCCGCCATGAGCTC	0.592			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				14	13					0	0	0.000151284	0	0
BCL11A	53335	broad.mit.edu	37	2	60687604	60687605	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr2:60687604_60687605GG>TT	uc002sae.1	-	4	2670_2671	c.2442_2443CC>AA	c.(2440-2445)ACCCTG>ACAATG	p.L815M	BCL11A_uc002sab.2_Intron|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Intron|BCL11A_uc010ypj.1_Intron|BCL11A_uc002sad.1_Missense_Mutation_p.L663M|BCL11A_uc002saf.1_Missense_Mutation_p.L781M	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	815	C2H2-type 6.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TGTTTCTCCAGGGTACTGTACA	0.426			T	IGH@	B-CLL								14	449					0	0	6.4e-05	0	0
TET3	200424	broad.mit.edu	37	2	74275057	74275057	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr2:74275057C>A	uc002skb.3	+	1	1608	c.1608C>A	c.(1606-1608)CCC>CCA	p.P536P	TET3_uc010fez.1_Silent_p.P536P	NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	536							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						CACCTAGTCCCTCCAGGGACA	0.647													9	7					0.000274275	0.00244624	0.000274275	1	0
ZNF514	84874	broad.mit.edu	37	2	95815421	95815421	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr2:95815421C>A	uc002sue.1	-	5	1183	c.809G>T	c.(808-810)AGC>ATC	p.S270I	ZNF514_uc002sud.1_Missense_Mutation_p.S343I	NM_032788	NP_116177	Q96K75	ZN514_HUMAN	zinc finger protein 514	270	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CGAACTCTGGCTGAAGGCTCT	0.428													22	27					1.50039e-11	2.2253e-10	0.000229342	1	0
NCAPH	23397	broad.mit.edu	37	2	97009953	97009953	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr2:97009953G>T	uc002svz.1	+	6	790	c.706G>T	c.(706-708)GAT>TAT	p.D236Y	NCAPH_uc010fhu.1_Missense_Mutation_p.D212Y|NCAPH_uc010fhv.1_Missense_Mutation_p.D225Y|NCAPH_uc010yum.1_Missense_Mutation_p.D212Y|NCAPH_uc010fhw.1_Missense_Mutation_p.D225Y|NCAPH_uc010yun.1_Missense_Mutation_p.D100Y|NCAPH_uc002swa.1_Intron	NM_015341	NP_056156	Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	236					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				urinary_tract(1)|skin(1)	2		Ovarian(717;0.0221)				CTCCGAAGCAGATCGGAAGTG	0.468													30	40					1.99505e-19	4.38911e-18	0.000409698	1	0
IL1F7	27178	broad.mit.edu	37	2	113675292	113675292	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr2:113675292G>T	uc002tij.2	+	4	388	c.346G>T	c.(346-348)GGG>TGG	p.G116W	IL1F7_uc002tik.2_Missense_Mutation_p.G95W|IL1F7_uc002til.2_Missense_Mutation_p.G76W|IL1F7_uc002tim.2_Missense_Mutation_p.G55W|IL1F7_uc002tin.2_Missense_Mutation_p.G90W	NM_014439	NP_055254	Q9NZH6	IL37_HUMAN	interleukin 1 family, member 7 isoform 1	116					immune response	cytosol|extracellular space|nucleus	cytokine activity|interleukin-1 receptor antagonist activity|interleukin-1 receptor binding				0						GGTCTCTAAAGGGGAGTTTTG	0.483													36	44					2.05212e-20	4.72465e-19	0.00111076	1	0
GLI2	2736	broad.mit.edu	37	2	121736037	121736037	+	Nonsense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr2:121736037G>T	uc010flp.2	+	9	1426	c.1396G>T	c.(1396-1398)GAG>TAG	p.E466*	GLI2_uc002tmq.1_Nonsense_Mutation_p.E138*|GLI2_uc002tmr.1_Nonsense_Mutation_p.E121*|GLI2_uc002tmt.3_Nonsense_Mutation_p.E138*|GLI2_uc002tmu.3_Nonsense_Mutation_p.E121*|GLI2_uc002tmw.1_Nonsense_Mutation_p.E449*	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	466					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				CATCCACGGGGAGAAGAAGGA	0.632													34	65					3.33393e-15	6.14064e-14	0.000953801	1	0
CYP27C1	339761	broad.mit.edu	37	2	127950714	127950714	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr2:127950714C>A	uc002tod.2	-	7	1089	c.958G>T	c.(958-960)GGG>TGG	p.G320W		NM_001001665	NP_001001665	Q4G0S4	C27C1_HUMAN	cytochrome P450, family 27, subfamily C,	320						membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)		ATTCTCCGCCCTATGCAGCTG	0.557													12	19					9.16793e-09	1.15254e-07	0.000566183	1	0
ZRANB3	84083	broad.mit.edu	37	2	136033229	136033229	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr2:136033229T>G	uc002tum.2	-	9	1180	c.1063A>C	c.(1063-1065)ACA>CCA	p.T355P	ZRANB3_uc002tuk.2_5'UTR|ZRANB3_uc002tul.2_Missense_Mutation_p.T355P|ZRANB3_uc002tun.1_Missense_Mutation_p.T295P	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	355	Helicase C-terminal.					intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)		ACTGCTTCTGTGCAAGCTTGG	0.328													9	27					0	0	0.000978159	0	0
GALNT13	114805	broad.mit.edu	37	2	155265526	155265526	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr2:155265526G>T	uc002tyr.3	+	11	1894	c.1327G>T	c.(1327-1329)GAC>TAC	p.D443Y	GALNT13_uc002tyt.3_Missense_Mutation_p.D443Y|GALNT13_uc010foc.1_Missense_Mutation_p.D262Y|GALNT13_uc010fod.2_Missense_Mutation_p.D196Y	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	443	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						TCAGTGTTTAGACAACATGGG	0.368													31	36					8.53417e-09	1.07628e-07	0.000491102	1	0
HNRNPA3	220988	broad.mit.edu	37	2	178080308	178080308	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr2:178080308T>A	uc002ulb.1	+	2	220	c.114T>A	c.(112-114)TTT>TTA	p.F38L	HNRNPA3_uc002ulc.1_Missense_Mutation_p.F38L|HNRNPA3_uc002uld.2_Missense_Mutation_p.F16L|HNRNPA3_uc002ule.2_5'Flank	NM_194247	NP_919223	P51991	ROA3_HUMAN	heterogeneous nuclear ribonucleoprotein A3	38	RRM 1.					catalytic step 2 spliceosome|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding			ovary(2)	2						GAAAACTGTTTATTGGTGGTC	0.393													21	26					0	0	0.000295444	0	0
TTN	7273	broad.mit.edu	37	2	179436938	179436938	+	Nonsense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr2:179436938C>A	uc010zfg.1	-	275	66441	c.66217G>T	c.(66217-66219)GAG>TAG	p.E22073*	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Nonsense_Mutation_p.E15768*|TTN_uc010zfi.1_Nonsense_Mutation_p.E15701*|TTN_uc010zfj.1_Nonsense_Mutation_p.E15576*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23000							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCATCATGCTCTGGTTTCTCC	0.483													14	23					4.7546e-09	6.09328e-08	0.000422831	1	0
TTN	7273	broad.mit.edu	37	2	179585273	179585273	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr2:179585273C>T	uc010zfg.1	-	77	19708	c.19484G>A	c.(19483-19485)CGA>CAA	p.R6495Q	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.R3156Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7422							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACCTGCTTTCGATCTTTAAC	0.388													16	19					0	0	0.000308642	0	0
CASP10	843	broad.mit.edu	37	2	202052510	202052510	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr2:202052510C>A	uc002uxl.1	+	3	847	c.429C>A	c.(427-429)CCC>CCA	p.P143P	CASP10_uc002uxi.1_Silent_p.P143P|CASP10_uc010zhn.1_Intron|CASP10_uc002uxj.1_Silent_p.P143P|CASP10_uc002uxk.1_Silent_p.P143P|CASP10_uc010fta.1_Silent_p.P143P|CASP10_uc002uxm.1_Silent_p.P143P|CASP10_uc010ftb.1_RNA	NM_032974	NP_116756	Q92851	CASPA_HUMAN	caspase 10 isoform b preproprotein	143	DED 2.				apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			skin(3)|ovary(1)|pancreas(1)|breast(1)	6						ACTCGCTTCCCAAAACTGAAA	0.418													23	33					7.87624e-14	1.35021e-12	0.000375601	1	0
FAM117B	150864	broad.mit.edu	37	2	203622026	203622026	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr2:203622026G>T	uc010zhx.1	+	6	1205	c.1195G>T	c.(1195-1197)GGG>TGG	p.G399W		NM_173511	NP_775782	Q6P1L5	F117B_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	399										ovary(1)	1						GACGCCTGGTGGGGCAGACAG	0.562													98	193					2.99567e-70	1.00533e-68	0.000781405	1	0
RAPH1	65059	broad.mit.edu	37	2	204305427	204305427	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr2:204305427G>T	uc002vad.2	-	14	2711	c.2486C>A	c.(2485-2487)CCT>CAT	p.P829H		NM_213589	NP_998754	Q70E73	RAPH1_HUMAN	Ras association and pleckstrin homology domains	829					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				ovary(3)|breast(3)|central_nervous_system(2)|lung(1)|skin(1)	10						AGGAGGGGTAGGGGGAGAGGG	0.587													17	21					8.60227e-14	1.46832e-12	0.000422831	1	0
PNKD	25953	broad.mit.edu	37	2	219204768	219204768	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr2:219204768C>A	uc002vhn.2	+	4	513	c.369C>A	c.(367-369)CCC>CCA	p.P123P	PNKD_uc002vhq.2_Silent_p.P99P	NM_015488	NP_056303	Q8N490	PNKD_HUMAN	myofibrillogenesis regulator 1 isoform 1	123						membrane|mitochondrion|nucleus	hydroxyacylglutathione hydrolase activity|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;7.33e-07)|all cancers(144;0.000133)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGGTGCTTCCCATCCCTGTCC	0.647													15	26					2.32078e-09	3.05326e-08	0.000308642	1	0
TMEM198	130612	broad.mit.edu	37	2	220412545	220412545	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr2:220412545C>A	uc002vme.2	+	4	1069	c.484C>A	c.(484-486)CTG>ATG	p.L162M	TMEM198_uc002vmf.2_Missense_Mutation_p.L162M	NM_001005209	NP_001005209	Q66K66	TM198_HUMAN	transmembrane protein 198	162	Helical; (Potential).|Leu-rich.					integral to membrane				ovary(1)	1		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GCTCTGTGCCCTGCTCACTCT	0.706													7	19					0.000157383	0.00142617	0.000157383	1	0
MIR562	693147	broad.mit.edu	37	2	233037384	233037384	+	RNA	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr2:233037384G>T	hsa-mir-562|MI0003568	+			c.22G>T			DIS3L2_uc010fxz.2_Intron|DIS3L2_uc002vsm.3_Intron|DIS3L2_uc002vso.2_Intron																	0						taggtcatatggtcagtctac	0													7	14					8.12818e-05	0.000757356	8.12818e-05	1	0
ATRN	8455	broad.mit.edu	37	20	3556568	3556568	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr20:3556568C>A	uc002wim.2	+	13	2277	c.2187C>A	c.(2185-2187)CCC>CCA	p.P729P	ATRN_uc002wil.2_Silent_p.P729P	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	729	Extracellular (Potential).|PSI 1.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						ATTGTGTCCCCAGGAACCACA	0.458													17	28					3.41278e-10	4.75867e-09	0.000566183	1	0
FRG1B	284802	broad.mit.edu	37	20	29628245	29628245	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr20:29628245G>A	uc010ztl.1	+	3	189	c.157G>A	c.(157-159)GCC>ACC	p.A53T	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Missense_Mutation_p.A5T					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						GGCTTTGTTGGCCTCAAATAG	0.353													5	99					0	0	0.000602214	0	0
KIF3B	9371	broad.mit.edu	37	20	30904662	30904662	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr20:30904662G>T	uc002wxq.2	+	5	1900	c.1733G>T	c.(1732-1734)AGG>ATG	p.R578M	KIF3B_uc010ztw.1_Missense_Mutation_p.R516M	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	578	Potential.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GAGCTCACCAGGGAGCTGAAA	0.488													7	51					0.000157383	0.00142617	0.000157383	1	0
GGT7	2686	broad.mit.edu	37	20	33442705	33442705	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr20:33442705G>T	uc002xay.2	-	9	1167	c.1124C>A	c.(1123-1125)CCA>CAA	p.P375Q	GGT7_uc002xaz.1_Missense_Mutation_p.P392Q	NM_178026	NP_821158	Q9UJ14	GGT7_HUMAN	gamma-glutamyltransferase 7	375	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(1)	1						GTGCGGAGGTGGGGGACTAAG	0.582													13	21					4.3838e-07	4.8627e-06	0.000151284	1	0
GGT7	2686	broad.mit.edu	37	20	33444642	33444642	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr20:33444642G>T	uc002xay.2	-	8	1112	c.1069C>A	c.(1069-1071)CTT>ATT	p.L357I	GGT7_uc002xaz.1_Missense_Mutation_p.L374I	NM_178026	NP_821158	Q9UJ14	GGT7_HUMAN	gamma-glutamyltransferase 7	357	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(1)	1						TTCTCCACAAGGGCGCTGTAA	0.597													9	14					3.07112e-06	3.15886e-05	0.000978159	1	0
PTPRT	11122	broad.mit.edu	37	20	41385186	41385186	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr20:41385186G>T	uc002xkg.2	-	6	959	c.775C>A	c.(775-777)CAG>AAG	p.Q259K	PTPRT_uc010ggj.2_Missense_Mutation_p.Q259K	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	259	Extracellular (Potential).|Ig-like C2-type.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ACGCTCCGCTGGGCAGTGTCT	0.602													20	17					7.41877e-09	9.38605e-08	0.000229342	1	0
RIMS4	140730	broad.mit.edu	37	20	43399954	43399954	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr20:43399954G>T	uc002xms.2	-	2	198	c.198C>A	c.(196-198)TCC>TCA	p.S66S	RIMS4_uc010ggu.2_Silent_p.S67S	NM_182970	NP_892015	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	66					exocytosis|neurotransmitter transport	cell junction|synapse				ovary(4)|central_nervous_system(1)	5		Myeloproliferative disorder(115;0.0122)				TGTCCTCAATGGACTCGTGGC	0.647													33	45					6.00712e-18	1.23897e-16	0.000409698	1	0
CDH22	64405	broad.mit.edu	37	20	44815548	44815548	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr20:44815548G>T	uc002xrm.2	-	8	1863	c.1462C>A	c.(1462-1464)CGA>AGA	p.R488R	CDH22_uc010ghk.1_Silent_p.R488R	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	488	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				TCCAGGATTCGGATCCTTAGG	0.572													6	216					0.000274275	0.00244624	0.000274275	1	0
KCNB1	3745	broad.mit.edu	37	20	47990039	47990039	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr20:47990039G>T	uc002xur.1	-	2	2222	c.2058C>A	c.(2056-2058)CCC>CCA	p.P686P	KCNB1_uc002xus.1_Silent_p.P686P	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	686	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TCCCTAGAACGGGGAGGAGTG	0.557													26	29					2.27525e-19	4.95055e-18	0.000586117	1	0
PTGIS	5740	broad.mit.edu	37	20	48124461	48124461	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr20:48124461G>T	uc002xut.2	-	10	1553	c.1499C>A	c.(1498-1500)CCA>CAA	p.P500Q	PTGIS_uc010zyi.1_Missense_Mutation_p.P361Q	NM_000961	NP_000952	Q16647	PTGIS_HUMAN	prostaglandin I2 synthase	500					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	CCTGTGTCATGGGCGGATGCG	0.527													22	28					1.88708e-17	3.79333e-16	0.000227799	1	0
CASS4	57091	broad.mit.edu	37	20	55012539	55012539	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr20:55012539G>T	uc002xxp.2	+	3	581	c.356G>T	c.(355-357)TGG>TTG	p.W119L	CASS4_uc002xxq.3_Missense_Mutation_p.W119L|CASS4_uc002xxr.2_Missense_Mutation_p.W119L|CASS4_uc010zze.1_Intron|CASS4_uc010gio.2_Missense_Mutation_p.W119L	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	119					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3						ATGAGGAGTTGGGCGGAGGGG	0.592													45	76					8.04919e-23	1.9798e-21	0.000781405	1	0
CDH26	60437	broad.mit.edu	37	20	58571080	58571080	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr20:58571080C>A	uc002ybe.2	+	12	2159	c.1859C>A	c.(1858-1860)CCT>CAT	p.P620H	CDH26_uc002ybf.1_Missense_Mutation_p.P200H|CDH26_uc010zzy.1_RNA|CDH26_uc002ybg.2_Missense_Mutation_p.P134H|CDH26_uc002ybh.2_5'Flank|CDH26_uc002ybi.2_5'Flank	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	620	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			GCCCTGTTCCCTGTCTGTGCA	0.592													18	19					0.000229342	0.0020735	0.000229342	1	0
SS18L1	26039	broad.mit.edu	37	20	60737980	60737980	+	Silent	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr20:60737980C>T	uc002ycb.2	+	5	604	c.549C>T	c.(547-549)TCC>TCT	p.S183S	SS18L1_uc011aaa.1_Silent_p.S183S|SS18L1_uc002ybz.1_RNA|SS18L1_uc002yca.1_RNA|SS18L1_uc002ycc.1_RNA	NM_198935	NP_945173	O75177	CREST_HUMAN	SS18-like protein 1	183	Methionine-rich intra-molecular domain (By similarity).				chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed chromosome kinetochore				ovary(2)	2	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.92e-08)			ACATGCAGTCCAACCCAGGTA	0.652			T	SSX1	synovial sarcoma								13	12					0	0	0.000151284	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19647594	19647594	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr21:19647594G>T	uc002ykw.2	-	24	2855	c.2824C>A	c.(2824-2826)CAA>AAA	p.Q942K		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	942	Extracellular (Potential).|Peptidase S1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						ATCTGCTGTTGGCATCTCTCA	0.398													46	78					7.05121e-23	1.75615e-21	0.000509022	1	0
CLDN17	26285	broad.mit.edu	37	21	31538470	31538470	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr21:31538470C>A	uc011acv.1	-	1	466	c.466G>T	c.(466-468)GGT>TGT	p.G156C		NM_012131	NP_036263	P56750	CLD17_HUMAN	claudin 17	156	Extracellular (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	Golgi apparatus|integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(2)	2						CGTTTCTGACCTATGTGGATG	0.517													26	34					4.26978e-12	6.57911e-11	0.00047179	1	0
CLDN8	9073	broad.mit.edu	37	21	31587640	31587640	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr21:31587640G>T	uc002ynu.1	-	1	679	c.604C>A	c.(604-606)CAT>AAT	p.H202N		NM_199328	NP_955360	P56748	CLD8_HUMAN	claudin 8	202	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity				0						GTTGTGCGATGGGAAGGTATC	0.443													30	67					3.03874e-20	6.91575e-19	0.00058488	1	0
IGSF5	150084	broad.mit.edu	37	21	41165479	41165479	+	Missense_Mutation	SNP	C	A	A	rs148668253		TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr21:41165479C>A	uc002yyo.2	+	8	1170	c.1067C>A	c.(1066-1068)CCC>CAC	p.P356H		NM_001080444	NP_001073913	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily 5 like	356	Cytoplasmic (Potential).					integral to membrane|tight junction					0		Prostate(19;5.35e-06)				TCTCTCCCTCCCAAATCCTGT	0.423													40	107					3.86236e-30	1.10036e-28	0.000781405	1	0
KRTAP10-11	386678	broad.mit.edu	37	21	46066631	46066631	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr21:46066631C>A	uc002zfr.3	+	1	301	c.256C>A	c.(256-258)CAG>AAG	p.Q86K	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198692	NP_941965	P60412	KR10B_HUMAN	keratin associated protein 10-11	86	25 X 5 AA repeats of C-C-X(3).					keratin filament				ovary(1)	1						GTCTAGCTGCCAGCCGGCTTG	0.428													25	46					8.24728e-16	1.54783e-14	0.000720815	1	0
KRTAP12-2	353323	broad.mit.edu	37	21	46086528	46086528	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr21:46086528G>T	uc002zfu.2	-	1	317	c.276C>A	c.(274-276)CCC>CCA	p.P92P	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_181684	NP_859012	P59991	KR122_HUMAN	keratin associated protein 12-2	92	15.|23 X 5 AA approximate repeats.					keratin filament					0						CACACACAATGGGCCTGCAGC	0.627													19	34					1.01871e-10	1.4723e-09	0.000132079	1	0
Unknown	0	broad.mit.edu	37	22	20294137	20294137	+	RNA	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:20294137G>A	uc002zrw.1	+	1		c.2577G>A								Homo sapiens mRNA for KIAA1653 protein, partial cds.																		GACTCATGCAGAAGAGGGCAC	0.627													24	11					0	0	0.000295444	0	0
LOC96610	96610	broad.mit.edu	37	22	23029766	23029766	+	RNA	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:23029766G>T	uc011aim.1	+	129		c.8388G>T								Parts of antibodies, mostly variable regions.												0						CAAGCAGACAGGGAAGTGAGA	0.517													13	56					4.3838e-07	4.8627e-06	0.000151284	1	0
LOC96610	96610	broad.mit.edu	37	22	23029791	23029791	+	RNA	SNP	C	A	A	rs144360672	by1000genomes	TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:23029791C>A	uc011aim.1	+	130		c.8399C>A								Parts of antibodies, mostly variable regions.												0						AACCCCTCCCCCTCTATTTCA	0.517													14	23					7.93312e-07	8.60689e-06	0.000219431	1	0
LOC96610	96610	broad.mit.edu	37	22	23223476	23223476	+	RNA	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:23223476C>T	uc011aim.1	+	334		c.14611C>T								Parts of antibodies, mostly variable regions.												0						GATTCTCTGGCTCCAACTCTG	0.562													8	46					0	0	0.000157383	0	0
SYN3	8224	broad.mit.edu	37	22	32929779	32929779	+	Silent	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:32929779C>T	uc003amx.2	-	9	1254	c.1095G>A	c.(1093-1095)GAG>GAA	p.E365E	SYN3_uc003amy.2_Silent_p.E365E|SYN3_uc003amz.2_Silent_p.E364E	NM_003490	NP_003481	O14994	SYN3_HUMAN	synapsin III isoform IIIa	365	C; actin-binding and synaptic-vesicle binding.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			skin(1)	1						CATCCCTCACCTCGATGATGT	0.602													10	60					0	0	0.000978159	0	0
ISX	91464	broad.mit.edu	37	22	35481452	35481452	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:35481452C>A	uc003anj.2	+	4	1455	c.504C>A	c.(502-504)CCC>CCA	p.P168P	ISX_uc011amg.1_Silent_p.P156P	NM_001008494	NP_001008494	Q2M1V0	ISX_HUMAN	intestine-specific homeobox	168						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)	5						GACAGGGGCCCACGTGGACAT	0.547													20	163					9.62636e-23	2.35311e-21	0.000295444	1	0
ELFN2	114794	broad.mit.edu	37	22	37770177	37770177	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:37770177G>T	uc003asq.3	-	3	2184	c.1398C>A	c.(1396-1398)CCC>CCA	p.P466P		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	466	Cytoplasmic (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					TGCGAGATACGGGCAGCACGG	0.647													42	104					3.77016e-25	9.95322e-24	0.000680045	1	0
TRIOBP	11078	broad.mit.edu	37	22	38086703	38086703	+	Splice_Site	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:38086703G>T	uc003atq.1	+	5	438	c.-596_splice	c.e5-1		NOL12_uc011anm.1_Splice_Site_p.G128_splice|NOL12_uc003ato.1_Splice_Site|NOL12_uc003atp.2_Splice_Site_p.G128_splice	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6						actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					TGCCTCTTTAGGGAGGGGCTG	0.622													17	184					1.01871e-10	1.4723e-09	0.000132079	1	0
TAB1	10454	broad.mit.edu	37	22	39811105	39811105	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:39811105G>A	uc003axt.2	+	2	177	c.128G>A	c.(127-129)GGC>GAC	p.G43D	TAB1_uc003axr.2_Missense_Mutation_p.G119D|TAB1_uc011aok.1_5'UTR|TAB1_uc003axu.1_Missense_Mutation_p.G43D	NM_006116	NP_006107	Q15750	TAB1_HUMAN	mitogen-activated protein kinase kinase kinase 7	43					activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)	1						GATGGCAAGGGCACTGAGAGC	0.612													50	116					0	0	0.000781405	0	0
ENTHD1	150350	broad.mit.edu	37	22	40161412	40161413	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:40161412_40161413GG>TT	uc003ayg.2	-	6	1285_1286	c.1034_1035CC>AA	c.(1033-1035)CCC>CAA	p.P345Q		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	345										ovary(2)|skin(1)	3	Melanoma(58;0.0749)					CCCTTAAGTCGGGGCTGATAAA	0.411													6	137					0	0	6.4e-05	0	0
TNRC6B	23112	broad.mit.edu	37	22	40704566	40704566	+	Nonsense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:40704566G>T	uc011aor.1	+	16	4382	c.4171G>T	c.(4171-4173)GGA>TGA	p.G1391*	TNRC6B_uc003aym.2_Nonsense_Mutation_p.G587*|TNRC6B_uc003ayn.3_Nonsense_Mutation_p.G1281*|TNRC6B_uc003ayo.2_Nonsense_Mutation_p.G1138*	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	1391					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						GAAGGAGGCTGGAACCGAGTC	0.498													52	25					6.60958e-23	1.66713e-21	0.000781405	1	0
L3MBTL2	83746	broad.mit.edu	37	22	41622690	41622690	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:41622690G>T	uc003azo.2	+	13	1583	c.1529G>T	c.(1528-1530)TGG>TTG	p.W510L	L3MBTL2_uc010gyi.1_Missense_Mutation_p.W419L|L3MBTL2_uc003azn.2_RNA	NM_031488	NP_113676	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2	510	MBT 4.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3						ACTTTCAACTGGGAGAACTAC	0.552													19	54					5.26018e-13	8.57214e-12	0.000229342	1	0
EFCAB6	64800	broad.mit.edu	37	22	44107483	44107483	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:44107483C>A	uc003bdy.1	-	10	1118	c.903G>T	c.(901-903)AAG>AAT	p.K301N	EFCAB6_uc003bdz.1_Missense_Mutation_p.K149N|EFCAB6_uc010gzi.1_Missense_Mutation_p.K149N|EFCAB6_uc010gzk.1_RNA|EFCAB6_uc011aqa.1_Missense_Mutation_p.K195N|EFCAB6_uc003bea.1_Missense_Mutation_p.K298N	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	301	EF-hand 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				CCTTTTCAACCTTTTCATAAG	0.368													15	11					3.45872e-05	0.000334061	0.000422831	1	0
SMC1B	27127	broad.mit.edu	37	22	45795021	45795021	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:45795021T>G	uc003bgc.2	-	6	1119	c.1067A>C	c.(1066-1068)GAA>GCA	p.E356A	SMC1B_uc003bgd.2_Missense_Mutation_p.E356A|SMC1B_uc003bge.1_Missense_Mutation_p.E139A	NM_148674	NP_683515	Q8NDV3	SMC1B_HUMAN	SMC1 structural maintenance of chromosomes	356	Potential.				chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			ovary(2)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TAAAATTTCTTCCTCAATCTG	0.373													54	190					0	0	0.000781405	0	0
CERK	64781	broad.mit.edu	37	22	47086075	47086075	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:47086075A>G	uc003bia.2	-	12	1462	c.1355T>C	c.(1354-1356)GTT>GCT	p.V452A	CERK_uc010hae.2_Missense_Mutation_p.V254A	NM_022766	NP_073603	Q8TCT0	CERK1_HUMAN	ceramide kinase	452					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|ceramide metabolic process	integral to membrane of membrane fraction|membrane|nucleus	ATP binding|ceramide kinase activity|diacylglycerol kinase activity|magnesium ion binding			skin(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GACGCGATAAACTTCAACAAA	0.517													22	310					0	0	0.00047179	0	0
HDAC10	83933	broad.mit.edu	37	22	50686181	50686181	+	Silent	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:50686181C>T	uc003bkg.2	-	14	1735	c.1362G>A	c.(1360-1362)GAG>GAA	p.E454E	TUBGCP6_uc003bkb.1_5'Flank|TUBGCP6_uc010har.1_5'Flank|TUBGCP6_uc010has.1_5'Flank|TUBGCP6_uc010hau.1_5'Flank|HDAC10_uc003bke.2_Silent_p.E180E|HDAC10_uc003bkf.2_Silent_p.E180E|HDAC10_uc010hav.2_Silent_p.E434E|HDAC10_uc003bkh.2_Silent_p.E247E|HDAC10_uc003bki.2_Silent_p.E404E|HDAC10_uc003bkj.2_Intron|HDAC10_uc003bkk.1_Missense_Mutation_p.R126K	NM_032019	NP_114408	Q969S8	HDA10_HUMAN	histone deacetylase 10 isoform 1	454					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TGAGGGCCTCCTCCCGGGCCA	0.622													6	24					0	0	0.000274275	0	0
HDAC10	83933	broad.mit.edu	37	22	50686183	50686183	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:50686183C>T	uc003bkg.2	-	14	1733	c.1360G>A	c.(1360-1362)GAG>AAG	p.E454K	TUBGCP6_uc003bkb.1_5'Flank|TUBGCP6_uc010har.1_5'Flank|TUBGCP6_uc010has.1_5'Flank|TUBGCP6_uc010hau.1_5'Flank|HDAC10_uc003bke.2_Missense_Mutation_p.E180K|HDAC10_uc003bkf.2_Missense_Mutation_p.E180K|HDAC10_uc010hav.2_Missense_Mutation_p.E434K|HDAC10_uc003bkh.2_Missense_Mutation_p.E247K|HDAC10_uc003bki.2_Missense_Mutation_p.E404K|HDAC10_uc003bkj.2_Intron|HDAC10_uc003bkk.1_Silent_p.G125G	NM_032019	NP_114408	Q969S8	HDA10_HUMAN	histone deacetylase 10 isoform 1	454					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		AGGGCCTCCTCCCGGGCCAGG	0.632													6	24					0	0	0.000274275	0	0
HDAC10	83933	broad.mit.edu	37	22	50686332	50686332	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:50686332C>T	uc003bkg.2	-	13	1697	c.1324G>A	c.(1324-1326)GAA>AAA	p.E442K	TUBGCP6_uc003bkb.1_5'Flank|TUBGCP6_uc010har.1_5'Flank|TUBGCP6_uc010has.1_5'Flank|TUBGCP6_uc010hau.1_5'Flank|HDAC10_uc003bke.2_Missense_Mutation_p.E168K|HDAC10_uc003bkf.2_Missense_Mutation_p.E168K|HDAC10_uc010hav.2_Missense_Mutation_p.E422K|HDAC10_uc003bkh.2_Missense_Mutation_p.E235K|HDAC10_uc003bki.2_Missense_Mutation_p.E392K|HDAC10_uc003bkj.2_RNA|HDAC10_uc003bkk.1_Missense_Mutation_p.E76K	NM_032019	NP_114408	Q969S8	HDA10_HUMAN	histone deacetylase 10 isoform 1	442					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCCCAGGCTTCTGTCTCCTCC	0.632													14	10					0	0	0.000375601	0	0
HDAC10	83933	broad.mit.edu	37	22	50686339	50686339	+	Silent	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:50686339C>T	uc003bkg.2	-	13	1690	c.1317G>A	c.(1315-1317)GAG>GAA	p.E439E	TUBGCP6_uc003bkb.1_5'Flank|TUBGCP6_uc010har.1_5'Flank|TUBGCP6_uc010has.1_5'Flank|TUBGCP6_uc010hau.1_5'Flank|HDAC10_uc003bke.2_Silent_p.E165E|HDAC10_uc003bkf.2_Silent_p.E165E|HDAC10_uc010hav.2_Silent_p.E419E|HDAC10_uc003bkh.2_Silent_p.E232E|HDAC10_uc003bki.2_Silent_p.E389E|HDAC10_uc003bkj.2_RNA|HDAC10_uc003bkk.1_Silent_p.E73E	NM_032019	NP_114408	Q969S8	HDA10_HUMAN	histone deacetylase 10 isoform 1	439					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CTTCTGTCTCCTCCCTCAGGG	0.647													18	9					0	0	0.000375601	0	0
HDAC10	83933	broad.mit.edu	37	22	50686341	50686341	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:50686341C>T	uc003bkg.2	-	13	1688	c.1315G>A	c.(1315-1317)GAG>AAG	p.E439K	TUBGCP6_uc003bkb.1_5'Flank|TUBGCP6_uc010har.1_5'Flank|TUBGCP6_uc010has.1_5'Flank|TUBGCP6_uc010hau.1_5'Flank|HDAC10_uc003bke.2_Missense_Mutation_p.E165K|HDAC10_uc003bkf.2_Missense_Mutation_p.E165K|HDAC10_uc010hav.2_Missense_Mutation_p.E419K|HDAC10_uc003bkh.2_Missense_Mutation_p.E232K|HDAC10_uc003bki.2_Missense_Mutation_p.E389K|HDAC10_uc003bkj.2_RNA|HDAC10_uc003bkk.1_Missense_Mutation_p.E73K	NM_032019	NP_114408	Q969S8	HDA10_HUMAN	histone deacetylase 10 isoform 1	439					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TCTGTCTCCTCCCTCAGGGCT	0.647													19	8					0	0	0.00047179	0	0
HDAC10	83933	broad.mit.edu	37	22	50686482	50686482	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:50686482C>T	uc003bkg.2	-	13	1547	c.1174G>A	c.(1174-1176)GCA>ACA	p.A392T	HDAC10_uc003bke.2_Missense_Mutation_p.A118T|HDAC10_uc003bkf.2_Missense_Mutation_p.A118T|HDAC10_uc010hav.2_Missense_Mutation_p.A372T|HDAC10_uc003bkh.2_Missense_Mutation_p.A185T|HDAC10_uc003bki.2_Missense_Mutation_p.A342T|HDAC10_uc003bkj.2_RNA|HDAC10_uc003bkk.1_Missense_Mutation_p.A26T	NM_032019	NP_114408	Q969S8	HDA10_HUMAN	histone deacetylase 10 isoform 1	392					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGTGCAGATGCAGCTGCCTTA	0.652													38	11					0	0	0.000814825	0	0
HDAC10	83933	broad.mit.edu	37	22	50686488	50686488	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:50686488C>T	uc003bkg.2	-	13	1541	c.1168G>A	c.(1168-1170)GCA>ACA	p.A390T	HDAC10_uc003bke.2_Missense_Mutation_p.A116T|HDAC10_uc003bkf.2_Missense_Mutation_p.A116T|HDAC10_uc010hav.2_Missense_Mutation_p.A370T|HDAC10_uc003bkh.2_Missense_Mutation_p.A183T|HDAC10_uc003bki.2_Missense_Mutation_p.A340T|HDAC10_uc003bkj.2_RNA|HDAC10_uc003bkk.1_Missense_Mutation_p.A24T	NM_032019	NP_114408	Q969S8	HDA10_HUMAN	histone deacetylase 10 isoform 1	390					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GATGCAGCTGCCTTACACACT	0.652													36	11					0	0	0.00058488	0	0
HDAC10	83933	broad.mit.edu	37	22	50686860	50686860	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:50686860C>T	uc003bkg.2	-	11	1321	c.948G>A	c.(946-948)ATG>ATA	p.M316I	HDAC10_uc003bke.2_Missense_Mutation_p.M42I|HDAC10_uc003bkf.2_Missense_Mutation_p.M42I|HDAC10_uc010hav.2_Missense_Mutation_p.M296I|HDAC10_uc003bkh.2_Intron|HDAC10_uc003bki.2_Missense_Mutation_p.M266I|HDAC10_uc003bkj.2_RNA|HDAC10_uc003bkk.1_5'UTR	NM_032019	NP_114408	Q969S8	HDA10_HUMAN	histone deacetylase 10 isoform 1	316	Histone deacetylase.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TCTGTACTGTCATGCACACTG	0.657													27	9					0	0	0.000409698	0	0
HDAC10	83933	broad.mit.edu	37	22	50686864	50686864	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr22:50686864C>T	uc003bkg.2	-	11	1317	c.944G>A	c.(943-945)TGC>TAC	p.C315Y	HDAC10_uc003bke.2_Missense_Mutation_p.C41Y|HDAC10_uc003bkf.2_Missense_Mutation_p.C41Y|HDAC10_uc010hav.2_Missense_Mutation_p.C295Y|HDAC10_uc003bkh.2_Intron|HDAC10_uc003bki.2_Missense_Mutation_p.C265Y|HDAC10_uc003bkj.2_RNA|HDAC10_uc003bkk.1_5'UTR	NM_032019	NP_114408	Q969S8	HDA10_HUMAN	histone deacetylase 10 isoform 1	315	Histone deacetylase.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TACTGTCATGCACACTGACTC	0.657													27	10					0	0	0.000491102	0	0
FANCD2	2177	broad.mit.edu	37	3	10128860	10128860	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:10128860C>A	uc003buw.2	+	34	3456	c.3378C>A	c.(3376-3378)CCC>CCA	p.P1126P	FANCD2_uc003bux.1_Silent_p.P1126P|FANCD2_uc003buy.1_Silent_p.P1126P|FANCD2_uc010hcw.1_RNA|C3orf24_uc003buz.2_Intron	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	1126					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		AAAGCATTCCCAGTTTCCAGT	0.383			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				52	116					2.76378e-25	7.34536e-24	0.000781405	1	0
SLC6A1	6529	broad.mit.edu	37	3	11064047	11064047	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:11064047G>T	uc010hdq.2	+	7	1018	c.607G>T	c.(607-609)GGG>TGG	p.G203W		NM_003042	NP_003033	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter	203	Extracellular (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)|skin(1)	2		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	GATGACGGACGGGCTGGATAA	0.597													8	8					3.09899e-07	3.48636e-06	0.000274275	1	0
NUP210	23225	broad.mit.edu	37	3	13420462	13420462	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:13420462G>T	uc003bxv.1	-	8	1078	c.995C>A	c.(994-996)GCT>GAT	p.A332D	NUP210_uc003bxx.2_Missense_Mutation_p.A4D	NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	332	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					TAACCTAGAAGCACCTTGCAT	0.498													39	51					1.48734e-19	3.30891e-18	0.000680045	1	0
GALNTL2	117248	broad.mit.edu	37	3	16217075	16217075	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:16217075G>T	uc003car.3	+	1	892	c.417G>T	c.(415-417)GAG>GAT	p.E139D	GALNTL2_uc003caq.3_Intron	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	139	Lumenal (Potential).					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						GGGCTGATGAGGACGGGGAGG	0.642													11	19					7.03913e-09	8.93428e-08	0.00010058	1	0
GALNTL2	117248	broad.mit.edu	37	3	16254193	16254193	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:16254193C>T	uc003car.3	+	6	1790	c.1315C>T	c.(1315-1317)CGC>TGC	p.R439C	GALNTL2_uc003caq.3_Missense_Mutation_p.R172C	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	439	Lumenal (Potential).					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						GAACAGGGTTCGCATTGCTGA	0.547													46	48					0	0	0.000781405	0	0
EPM2AIP1	9852	broad.mit.edu	37	3	37034262	37034262	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:37034262C>A	uc003cgk.2	-	1	534	c.307G>T	c.(307-309)GGG>TGG	p.G103W	MLH1_uc011aye.1_5'Flank|MLH1_uc003cgl.2_5'Flank|MLH1_uc011ayb.1_5'Flank|MLH1_uc010hge.2_5'Flank|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_014805	NP_055620	Q7L775	EPMIP_HUMAN	EPM2A interacting protein 1	103						endoplasmic reticulum					0						CGGCAGAGCCCGAGGCCTGCA	0.667													54	46					2.12129e-23	5.45473e-22	0.000781405	1	0
EXOSC7	23016	broad.mit.edu	37	3	45052801	45052801	+	Silent	SNP	C	A	A	rs140279197		TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:45052801C>A	uc003coi.2	+	8	875	c.846C>A	c.(844-846)CCC>CCA	p.P282P	EXOSC7_uc003coh.1_Silent_p.P217P|EXOSC7_uc010his.1_Silent_p.P201P|EXOSC7_uc003coj.2_Silent_p.P282P	NM_015004	NP_055819	Q15024	EXOS7_HUMAN	exosome component 7	282					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	3'-5'-exoribonuclease activity|protein binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00911)|KIRC - Kidney renal clear cell carcinoma(197;0.0509)|Kidney(197;0.064)		GCCTGGGGCCCAAGAGACAGA	0.473													20	18					1.66031e-10	2.35656e-09	0.000586117	1	0
CDCP1	64866	broad.mit.edu	37	3	45134896	45134896	+	Silent	SNP	C	G	G			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:45134896C>G	uc003com.2	-	6	1635	c.1500G>C	c.(1498-1500)CCG>CCC	p.P500P		NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	500	CUB.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		TAGAGCCTCCCGGGCAGAAGG	0.592													3	52					0	0	6.4e-05	0	0
CCR2	729230	broad.mit.edu	37	3	46399343	46399343	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:46399343G>T	uc003cpn.3	+	2	810	c.325G>T	c.(325-327)GGG>TGG	p.G109W	CCR2_uc003cpm.3_Missense_Mutation_p.G109W	NM_001123041	NP_001116513	P41597	CCR2_HUMAN	chemokine (C-C motif) receptor 2 isoform A	109	Extracellular (Potential).				astrocyte cell migration|blood vessel remodeling|cellular defense response|chemokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response|interspecies interaction between organisms|JAK-STAT cascade|monocyte extravasation|negative regulation of adenylate cyclase activity|negative regulation of angiogenesis|negative regulation of eosinophil degranulation|negative regulation of type 2 immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of immune complex clearance by monocytes and macrophages|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|positive regulation of T cell extravasation|positive regulation of T-helper 1 type immune response|positive regulation of tumor necrosis factor biosynthetic process|regulation of vascular endothelial growth factor production|T-helper 17 cell chemotaxis	cytosol|dendrite|integral to plasma membrane|perikaryon|perinuclear region of cytoplasm|soluble fraction	C-C chemokine receptor activity|CCR2 chemokine receptor binding|protein homodimerization activity			lung(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0174)|Kidney(197;0.0206)		GTGGGTCTTTGGGAATGCAAT	0.443													163	192					1.69274e-77	5.72926e-76	0.000781405	1	0
CELSR3	1951	broad.mit.edu	37	3	48697877	48697877	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:48697877G>T	uc003cul.2	-	1	2472	c.2191C>A	c.(2191-2193)CAT>AAT	p.H731N	CELSR3_uc003cuf.1_Missense_Mutation_p.H801N	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	731	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGTGAGCCATGGTCTCGAGCC	0.552													13	53					6.81908e-15	1.23304e-13	0.000219431	1	0
VPRBP	9730	broad.mit.edu	37	3	51440667	51440667	+	Nonsense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:51440667C>A	uc003dbe.1	-	23	4543	c.4375G>T	c.(4375-4377)GAG>TAG	p.E1459*	VPRBP_uc003dbf.1_Nonsense_Mutation_p.E735*	NM_014703	NP_055518	Q9Y4B6	VPRBP_HUMAN	HIV-1 Vpr binding protein	1459	Asp/Glu-rich (acidic).|Interaction with NF2.				interspecies interaction between organisms	cytoplasm|nucleus	protein binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		GCTAGCTCCTCATCAGAGGGA	0.532													10	22					2.80697e-09	3.64446e-08	0.000978159	1	0
VPRBP	9730	broad.mit.edu	37	3	51475839	51475839	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:51475839G>T	uc003dbe.1	-	8	756	c.588C>A	c.(586-588)CCC>CCA	p.P196P	VPRBP_uc003dbg.1_Silent_p.P196P	NM_014703	NP_055518	Q9Y4B6	VPRBP_HUMAN	HIV-1 Vpr binding protein	196					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		TCCGTGGACTGGGACGCTTGT	0.502													101	112					4.98208e-43	1.57832e-41	0.000781405	1	0
CD86	942	broad.mit.edu	37	3	121822564	121822564	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:121822564G>T	uc003eet.2	+	3	386	c.270G>T	c.(268-270)TCG>TCT	p.S90S	CD86_uc011bjo.1_Silent_p.S8S|CD86_uc011bjp.1_Intron|CD86_uc003eeu.2_Silent_p.S84S	NM_175862	NP_787058	P42081	CD86_HUMAN	CD86 antigen isoform 1	90	Ig-like V-type.|Extracellular (Potential).				interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			pancreas(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	GTTTTGATTCGGACAGTTGGA	0.438													37	78					1.69901e-12	2.68051e-11	0.00111076	1	0
C3orf27	23434	broad.mit.edu	37	3	128292485	128292485	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:128292485G>T	uc003ekq.2	-	3	1055	c.88C>A	c.(88-90)CAG>AAG	p.Q30K		NM_007354	NP_031380	O15544	GR6_HUMAN	putative GR6 protein	30											0				GBM - Glioblastoma multiforme(114;0.176)		GGGGGTCCCTGGAGGCGGGAG	0.607													10	18					2.27111e-07	2.57696e-06	0.00010058	1	0
TF	7018	broad.mit.edu	37	3	133473449	133473449	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:133473449G>T	uc003epu.1	+	9	2164	c.436G>T	c.(436-438)GGG>TGG	p.G146W	TF_uc011bls.1_Missense_Mutation_p.G146W|TF_uc011blt.1_Missense_Mutation_p.G19W|TF_uc003epw.1_Intron|TF_uc003epv.1_Missense_Mutation_p.G146W	NM_001063	NP_001054	P02787	TRFE_HUMAN	transferrin precursor	146	Transferrin-like 1.	Carbonate 1; via amide nitrogen.			cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			ovary(1)|skin(1)	2					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	CAGGTCCGCTGGGTGGAACAT	0.527													98	94					1.87388e-53	6.1327e-52	0.000781405	1	0
EPHB1	2047	broad.mit.edu	37	3	134670531	134670531	+	Missense_Mutation	SNP	C	A	A	rs35304388		TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:134670531C>A	uc003eqt.2	+	3	662	c.442C>A	c.(442-444)CAG>AAG	p.Q148K	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_Missense_Mutation_p.Q148K	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	148	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						GAGCTTCTCCCAGGTGGACTT	0.502													88	73					1.11079e-38	3.43652e-37	0.000781405	1	0
PRR23C	389152	broad.mit.edu	37	3	138762971	138762971	+	Silent	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:138762971C>T	uc011bmt.1	-	1	764	c.492G>A	c.(490-492)CCG>CCA	p.P164P		NM_001134657	NP_001128129	Q6ZRP0	PR23C_HUMAN	proline rich 23C	164										skin(1)	1						TCCAGAGCTCCGGGAACTCAG	0.657													4	4					0	0	0.000602214	0	0
SI	6476	broad.mit.edu	37	3	164737442	164737442	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:164737442C>A	uc003fei.2	-	28	3433	c.3371G>T	c.(3370-3372)CGA>CTA	p.R1124L		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1124	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTTCAGATCTCGCTTAAATGC	0.438										HNSCC(35;0.089)			26	34					1.16021e-09	1.56273e-08	0.000184323	1	0
MECOM	2122	broad.mit.edu	37	3	168834350	168834350	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:168834350C>T	uc003ffi.3	-	7	1015	c.746G>A	c.(745-747)GGA>GAA	p.G249E	MECOM_uc010hwk.1_Missense_Mutation_p.G272E|MECOM_uc003ffj.3_Missense_Mutation_p.G314E|MECOM_uc011bpi.1_Missense_Mutation_p.G250E|MECOM_uc003ffn.3_Missense_Mutation_p.G249E|MECOM_uc003ffk.2_Missense_Mutation_p.G249E|MECOM_uc003ffl.2_Missense_Mutation_p.G409E|MECOM_uc011bpj.1_Missense_Mutation_p.G437E|MECOM_uc011bpk.1_Missense_Mutation_p.G239E|MECOM_uc010hwn.2_Missense_Mutation_p.G437E	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	249	Interaction with MAPK9, SMAD3 and probably SUV39H1.				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						GCCAAAAAATCCACCTGCCGC	0.448													24	72					0	0	0.000720815	0	0
ALG3	10195	broad.mit.edu	37	3	183966536	183966536	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:183966536C>T	uc003fne.2	-	1	224	c.193G>A	c.(193-195)GCA>ACA	p.A65T	ALG3_uc011brc.1_Intron|ALG3_uc011brd.1_Missense_Mutation_p.G42D|ALG3_uc011bre.1_Intron|ALG3_uc003fnf.1_Intron|ALG3_uc011brf.1_Intron|ECE2_uc003fnh.3_5'Flank|ECE2_uc003fni.3_5'Flank	NM_005787	NP_005778	Q92685	ALG3_HUMAN	alpha-1,3-mannosyltransferase ALG3 isoform a	65					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	alpha-1,3-mannosyltransferase activity				0	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CACTCACATGCCACCCTGTGA	0.662													11	25					0	0	0.000978159	0	0
APOD	347	broad.mit.edu	37	3	195300832	195300832	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:195300832C>A	uc003fur.2	-	3	496	c.134G>T	c.(133-135)AGA>ATA	p.R45I	APOD_uc011bsx.1_Missense_Mutation_p.R45I	NM_001647	NP_001638	P05090	APOD_HUMAN	apolipoprotein D precursor	45					lipid metabolic process	extracellular space	lipid binding|lipid transporter activity|protein binding			ovary(2)	2	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		TTCGTACCATCTTCCGAGATA	0.488													18	43					2.37509e-13	3.96851e-12	0.000175454	1	0
MUC4	4585	broad.mit.edu	37	3	195492275	195492275	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:195492275G>T	uc011bto.1	-	10	13740	c.13280C>A	c.(13279-13281)CCC>CAC	p.P4427H	MUC4_uc003fuz.2_Missense_Mutation_p.P153H|MUC4_uc003fva.2_Missense_Mutation_p.P35H|MUC4_uc003fvb.2_Missense_Mutation_p.P71H|MUC4_uc003fvc.2_RNA|MUC4_uc003fvd.2_RNA|MUC4_uc003fve.2_Missense_Mutation_p.P71H|MUC4_uc010hzr.2_RNA|MUC4_uc011btf.1_Missense_Mutation_p.P35H|MUC4_uc011btg.1_RNA|MUC4_uc011bth.1_Missense_Mutation_p.P119H|MUC4_uc011bti.1_Missense_Mutation_p.P119H|MUC4_uc011btj.1_Missense_Mutation_p.P296H|MUC4_uc011btk.1_Missense_Mutation_p.P35H|MUC4_uc011btl.1_Missense_Mutation_p.P64H|MUC4_uc011btm.1_Missense_Mutation_p.P244H|MUC4_uc011btn.1_Missense_Mutation_p.P35H|MUC4_uc003fvo.2_Missense_Mutation_p.P319H|MUC4_uc003fvp.2_Missense_Mutation_p.P268H|MUC4_uc010hzu.1_Missense_Mutation_p.P1167H	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1312	AMOP.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		ACGGTAGTTGGGCCTTTCTTC	0.652													10	35					1.76689e-08	2.17295e-07	0.000442599	1	0
IQCG	84223	broad.mit.edu	37	3	197670838	197670838	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr3:197670838G>T	uc003fyo.2	-	3	239	c.93C>A	c.(91-93)ACC>ACA	p.T31T	IQCG_uc003fyp.2_Silent_p.T31T|IQCG_uc003fyq.3_Silent_p.T31T	NM_001134435	NP_001127907	Q9H095	IQCG_HUMAN	IQ motif containing G	31											0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		CTTCTTCTACGGTACTAGGTG	0.453													9	180					0.000442599	0.00392981	0.000442599	1	0
DGKQ	1609	broad.mit.edu	37	4	960292	960292	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr4:960292C>T	uc003gbw.2	-	12	1464	c.1390G>A	c.(1390-1392)GAA>AAA	p.E464K	DGKQ_uc010ibn.2_Missense_Mutation_p.E464K	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	464	Ras-associating.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			AGGGGCTGTTCGTCCATCAGC	0.701													26	8					0	0	0.000184323	0	0
RGS12	6002	broad.mit.edu	37	4	3318150	3318150	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr4:3318150G>T	uc003ggw.2	+	2	1157	c.253G>T	c.(253-255)GGG>TGG	p.G85W	RGS12_uc003ggu.2_Missense_Mutation_p.G85W|RGS12_uc010ics.1_Intron|RGS12_uc011bvr.1_RNA|RGS12_uc003ggv.2_Missense_Mutation_p.G85W|RGS12_uc003ggx.1_Missense_Mutation_p.G85W	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	85	PDZ.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GAAATTAATTGGGAAGTGCTC	0.488													11	50					5.50884e-06	5.55089e-05	0.00010058	1	0
CPZ	8532	broad.mit.edu	37	4	8613821	8613821	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr4:8613821G>T	uc003glm.2	+	8	1421	c.1295G>T	c.(1294-1296)AGG>ATG	p.R432M	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_Missense_Mutation_p.R295M|CPZ_uc003glo.2_Missense_Mutation_p.R421M|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	432					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						TCGGAGAATAGGTGTGGAGGC	0.498													8	37					5.18039e-06	5.24664e-05	0.000157383	1	0
NKX3-2	579	broad.mit.edu	37	4	13545655	13545655	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr4:13545655C>A	uc003gmx.2	-	1	460	c.384G>T	c.(382-384)CCG>CCT	p.P128P		NM_001189	NP_001180	P78367	NKX32_HUMAN	NK3 homeobox 2	128					negative regulation of chondrocyte differentiation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCTCACAGACCGGCTGGCCGA	0.537													5	6					2.7689e-08	3.39468e-07	8.12818e-05	1	0
FGFBP2	83888	broad.mit.edu	37	4	15964237	15964237	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr4:15964237C>A	uc003gon.2	-	1	623	c.516G>T	c.(514-516)CTG>CTT	p.L172L		NM_031950	NP_114156	Q9BYJ0	FGFP2_HUMAN	killer-specific secretory protein of 37 kDa	172						extracellular space	growth factor binding				0						TGGCTTTTCCCAGCTCTTCCA	0.587													36	127					5.2432e-18	1.08707e-16	0.000781405	1	0
SLIT2	9353	broad.mit.edu	37	4	20598100	20598100	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr4:20598100T>C	uc003gpr.1	+	32	3587	c.3383T>C	c.(3382-3384)TTT>TCT	p.F1128S	SLIT2_uc003gps.1_Missense_Mutation_p.F1120S	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	1128	EGF-like 6.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						TGTGATAATTTTGATTGTCAG	0.403													47	31					0	0	0.000781405	0	0
SLC30A9	10463	broad.mit.edu	37	4	42003751	42003751	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr4:42003751G>T	uc003gwl.2	+	2	374	c.228G>T	c.(226-228)CAG>CAT	p.Q76H	SLC30A9_uc011byx.1_Translation_Start_Site	NM_006345	NP_006336	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter),	76					nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3						AAGAAGGACAGGGATCACAAA	0.313													10	42					0.000673444	0.00587409	0.000673444	1	0
CWH43	80157	broad.mit.edu	37	4	49030677	49030677	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr4:49030677G>T	uc003gyv.2	+	10	1480	c.1298G>T	c.(1297-1299)TGG>TTG	p.W433L	CWH43_uc011bzl.1_Missense_Mutation_p.W406L	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	433					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						GCTGCCATCTGGCCTTTCAGG	0.443													21	64					3.7963e-18	7.9123e-17	0.00047179	1	0
UGT2B10	7365	broad.mit.edu	37	4	69879764	69879764	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr4:69879764C>T	uc011cao.1	-	6	1001	c.865G>A	c.(865-867)GCC>ACC	p.A289T	UGT2B10_uc011can.1_Missense_Mutation_p.A205T			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	326					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						TTGGCAAGGGCTGTTGCAATT	0.428													25	101					0	0	0.000720815	0	0
ANKRD17	26057	broad.mit.edu	37	4	73959836	73959836	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr4:73959836T>C	uc003hgp.2	-	28	5404	c.5287A>G	c.(5287-5289)AAA>GAA	p.K1763E	ANKRD17_uc003hgo.2_Missense_Mutation_p.K1650E|ANKRD17_uc003hgq.2_Missense_Mutation_p.K1512E|ANKRD17_uc003hgr.2_Missense_Mutation_p.K1762E	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1763	KH.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TCTTTCTGTTTATCAATATCT	0.358													44	33					0	0	0.000589545	0	0
FRAS1	80144	broad.mit.edu	37	4	79418010	79418010	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr4:79418010G>A	uc003hlb.2	+	60	9450	c.9010G>A	c.(9010-9012)GAA>AAA	p.E3004K	FRAS1_uc003hlc.1_Missense_Mutation_p.E6K	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2999	Calx-beta 4.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TGAGCCAGAGGAACAGTTCAG	0.448													121	88					0	0	0.000781405	0	0
HELQ	113510	broad.mit.edu	37	4	84350799	84350799	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr4:84350799G>T	uc003hom.2	-	12	2575	c.2396C>A	c.(2395-2397)ACT>AAT	p.T799N	HELQ_uc010ikb.2_Missense_Mutation_p.T732N|HELQ_uc003hol.3_RNA|HELQ_uc010ikc.2_RNA	NM_133636	NP_598375	Q8TDG4	HELQ_HUMAN	DNA helicase HEL308	799							ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|breast(1)|skin(1)	3						TGATTCAACAGTTATTTCCCA	0.313								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					24	44					2.70639e-06	2.82779e-05	0.000295444	1	0
GRID2	2895	broad.mit.edu	37	4	94032086	94032086	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr4:94032086C>A	uc011cdt.1	+	4	975	c.717C>A	c.(715-717)GCC>GCA	p.A239A	GRID2_uc010ikx.2_Silent_p.A239A|GRID2_uc011cdu.1_Silent_p.A144A|GRID2_uc011cdv.1_RNA	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	239	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CTGCTACAGCCAAATCCTTCA	0.393													19	105					1.2644e-06	1.35325e-05	0.000175454	1	0
NFKB1	4790	broad.mit.edu	37	4	103517372	103517372	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr4:103517372G>T	uc011ceq.1	+	14	1842	c.1375G>T	c.(1375-1377)GGG>TGG	p.G459W	NFKB1_uc011cep.1_Missense_Mutation_p.G460W|NFKB1_uc011cer.1_Missense_Mutation_p.G279W	NM_003998	NP_003989	P19838	NFKB1_HUMAN	nuclear factor kappa-B, subunit 1 isoform 1	459	Interaction with CFLAR.				anti-apoptosis|apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of calcidiol 1-monooxygenase activity|nerve growth factor receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter	cytosol|I-kappaB/NF-kappaB complex|mitochondrion|nucleoplasm	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|breast(2)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.59e-08)	Dexamethasone(DB01234)|Pranlukast(DB01411)|Thalidomide(DB01041)	AAACCTCTTTGGGAAAGTTAT	0.428													24	64					2.89027e-11	4.23906e-10	0.000295444	1	0
EGF	1950	broad.mit.edu	37	4	110909779	110909779	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr4:110909779C>A	uc003hzy.3	+	18	3100	c.2648C>A	c.(2647-2649)CCT>CAT	p.P883H	EGF_uc011cfu.1_Missense_Mutation_p.P841H|EGF_uc011cfv.1_Missense_Mutation_p.P883H|EGF_uc010imk.2_Intron	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	883	EGF-like 7; calcium-binding (Potential).|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	GTGTGCCCCCCTGCCTCCTCC	0.473													16	132					3.45872e-05	0.000334061	0.000422831	1	0
NDST3	9348	broad.mit.edu	37	4	119161824	119161824	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr4:119161824G>T	uc003ibx.2	+	11	2667	c.2264G>T	c.(2263-2265)TGG>TTG	p.W755L		NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	755	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						ATCGAGAGATGGCTTGTTTAT	0.463													15	23					3.52763e-06	3.60037e-05	0.000566183	1	0
NR3C2	4306	broad.mit.edu	37	4	149075847	149075847	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr4:149075847C>A	uc003ilj.3	-	5	2554	c.2220G>T	c.(2218-2220)ATG>ATT	p.M740I	NR3C2_uc003ilk.3_Intron|NR3C2_uc010iph.2_Intron	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	740	Steroid-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	TTTCAAGGACCATAACGGGGG	0.502													46	98					3.39706e-21	8.00734e-20	0.000781405	1	0
SPOCK3	50859	broad.mit.edu	37	4	167810285	167810285	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr4:167810285C>A	uc003iri.1	-	7	735	c.594G>T	c.(592-594)AAG>AAT	p.K198N	SPOCK3_uc011cjp.1_Missense_Mutation_p.K195N|SPOCK3_uc011cjq.1_Missense_Mutation_p.K207N|SPOCK3_uc011cjr.1_Missense_Mutation_p.K78N|SPOCK3_uc003irj.1_Missense_Mutation_p.K195N|SPOCK3_uc011cjs.1_Missense_Mutation_p.K147N|SPOCK3_uc011cjt.1_Missense_Mutation_p.K106N|SPOCK3_uc011cju.1_Missense_Mutation_p.K91N|SPOCK3_uc011cjv.1_Missense_Mutation_p.K100N|SPOCK3_uc003irk.3_Missense_Mutation_p.K195N|SPOCK3_uc011cjw.1_RNA	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	198					signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		ACTTACCTCTCTTAACATTTC	0.333													34	34					8.73648e-17	1.72122e-15	0.000814825	1	0
STOX2	56977	broad.mit.edu	37	4	184938351	184938351	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr4:184938351C>A	uc003ivz.1	+	4	4130	c.2695C>A	c.(2695-2697)CGA>AGA	p.R899R	uc003iwb.1_5'Flank|STOX2_uc003iwa.1_3'UTR	NM_020225	NP_064610	Q9P2F5	STOX2_HUMAN	storkhead box 2	899					embryo development|maternal placenta development						0		all_lung(41;1.89e-12)|Lung NSC(41;3.48e-12)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|all_hematologic(60;0.027)|Prostate(90;0.0283)		all cancers(43;2.85e-26)|Epithelial(43;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-10)|Colorectal(24;8.23e-06)|GBM - Glioblastoma multiforme(59;1.64e-05)|STAD - Stomach adenocarcinoma(60;3.6e-05)|COAD - Colon adenocarcinoma(29;4.37e-05)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.227)		CTTCAACTTCCGAGCGAGCGC	0.547													4	7					0.00024832	0.00223997	0.00024832	1	0
TERT	7015	broad.mit.edu	37	5	1278788	1278788	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:1278788G>T	uc003jcb.1	-	6	2312	c.2254C>A	c.(2254-2256)CAT>AAT	p.H752N	TERT_uc003jbz.1_Silent_p.P8P|TERT_uc003jca.1_Missense_Mutation_p.H740N|TERT_uc003jcc.1_Missense_Mutation_p.H752N|TERT_uc003jcd.1_RNA|TERT_uc003jce.1_RNA	NM_198253	NP_937983	O14746	TERT_HUMAN	telomerase reverse transcriptase isoform 1	752	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			lung(7)|ovary(2)|central_nervous_system(2)|skin(1)	12	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			ACGTGCCCATGGGCGGCCTTC	0.572									TERT_Mutation-Associated_Haematological_Disorders|Congenital_Dyskeratosis|Pulmonary_Fibrosis_Idiopathic				72	361					1.69816e-31	4.90854e-30	0.000781405	1	0
DNAH5	1767	broad.mit.edu	37	5	13753355	13753355	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:13753355C>T	uc003jfd.2	-	63	10901	c.10859G>A	c.(10858-10860)CGA>CAA	p.R3620Q	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3620	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GAGTTCATTTCGGCTTTCTTT	0.333									Kartagener_syndrome				19	158					0	0	0.000958276	0	0
OSMR	9180	broad.mit.edu	37	5	38924539	38924539	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:38924539C>G	uc003jln.1	+	14	2253	c.1886C>G	c.(1885-1887)CCT>CGT	p.P629R	OSMR_uc011cpj.1_5'UTR	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	629	Fibronectin type-III 4.|Extracellular (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					TCAGACAACCCTCACGTGCTG	0.408													18	92					0	0	0.000132079	0	0
RICTOR	253260	broad.mit.edu	37	5	38963125	38963125	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:38963125C>G	uc003jlp.2	-	17	1443	c.1419G>C	c.(1417-1419)TTG>TTC	p.L473F	RICTOR_uc003jlo.2_Missense_Mutation_p.L473F|RICTOR_uc010ivf.2_Missense_Mutation_p.L188F	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	473					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					TTAAACAGTTCAAGGCTGCAC	0.353													44	107					0	0	0.000437636	0	0
C9	735	broad.mit.edu	37	5	39331858	39331858	+	Nonsense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:39331858C>A	uc003jlv.3	-	5	624	c.535G>T	c.(535-537)GGA>TGA	p.G179*		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	179	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			TTACAGAGTCCATTGTAGAAC	0.438													55	280					1.17253e-29	3.29306e-28	0.000781405	1	0
PARP8	79668	broad.mit.edu	37	5	50129836	50129836	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:50129836C>A	uc003jon.3	+	25	2513	c.2331C>A	c.(2329-2331)TCC>TCA	p.S777S	PARP8_uc011cpz.1_Silent_p.S669S|PARP8_uc003joo.2_Silent_p.S777S|PARP8_uc003jop.2_Silent_p.S735S	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	777	PARP catalytic.		S -> A (in a colorectal cancer sample; somatic mutation).			intracellular	NAD+ ADP-ribosyltransferase activity	p.S777A(1)		lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				GACAGCAATCCCAATTCCTGC	0.323													16	52					4.96729e-08	5.87178e-07	0.000132079	1	0
CMYA5	202333	broad.mit.edu	37	5	79030367	79030367	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:79030367G>T	uc003kgc.2	+	2	5851	c.5779G>T	c.(5779-5781)GGG>TGG	p.G1927W		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1927						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GCTGAGGCCAGGGCAGCTCAA	0.498													16	35					1.15088e-07	1.32485e-06	0.000422831	1	0
EDIL3	10085	broad.mit.edu	37	5	83402504	83402504	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:83402504C>A	uc003kio.1	-	6	1033	c.614G>T	c.(613-615)TGG>TTG	p.W205L	EDIL3_uc003kip.1_Missense_Mutation_p.W195L	NM_005711	NP_005702	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like	205	F5/8 type C 1.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			skin(2)	2		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		TGCAGCTGTCCACGCATTTAT	0.413													9	88					7.48243e-07	8.16265e-06	0.000442599	1	0
CCNH	902	broad.mit.edu	37	5	86690864	86690864	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:86690864C>A	uc003kjb.2	-	8	1162	c.930G>T	c.(928-930)GAG>GAT	p.E310D	CCNH_uc003kiy.1_RNA|CCNH_uc003kiz.1_Missense_Mutation_p.E257D|CCNH_uc003kja.2_Missense_Mutation_p.E257D	NM_001239	NP_001230	P51946	CCNH_HUMAN	cyclin H	310	Poly-Glu.				G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	cyclin-dependent protein kinase activating kinase holoenzyme complex|holo TFIIH complex	protein kinase binding			ovary(2)|kidney(1)	3		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;9.01e-39)|Epithelial(54;5.08e-33)|all cancers(79;4.28e-28)		AACATACCTCCTCATGTTTGG	0.343								Direct_reversal_of_damage|NER					51	164					1.4709e-25	3.93565e-24	0.000781405	1	0
GPR98	84059	broad.mit.edu	37	5	89933721	89933721	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:89933721T>G	uc003kju.2	+	11	2292	c.2196T>G	c.(2194-2196)GAT>GAG	p.D732E	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	732	Calx-beta 5.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCAAAGGTGATGACATACCGG	0.363													15	39					0	0	0.00074312	0	0
CDO1	1036	broad.mit.edu	37	5	115152014	115152014	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:115152014C>A	uc003krg.2	-	1	392	c.81G>T	c.(79-81)GAG>GAT	p.E27D		NM_001801	NP_001792	Q16878	CDO1_HUMAN	cysteine dioxygenase	27					inflammatory response|sulfur amino acid biosynthetic process|taurine biosynthetic process	cytosol	cysteine dioxygenase activity			large_intestine(1)|skin(1)	2		all_cancers(142;0.0046)|all_epithelial(76;0.000161)|Prostate(80;0.0132)|Ovarian(225;0.0776)		OV - Ovarian serous cystadenocarcinoma(64;7.8e-08)|Epithelial(69;7.32e-07)|all cancers(49;3.24e-05)	L-Cysteine(DB00151)|NADH(DB00157)	CTACATTGACCTCATCGCCGG	0.607													57	84					9.77497e-20	2.18694e-18	0.000781405	1	0
TIFAB	497189	broad.mit.edu	37	5	134785550	134785550	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:134785550G>T	uc003law.3	-	2	281	c.80C>A	c.(79-81)CCA>CAA	p.P27Q	C5orf20_uc003lav.2_5'Flank	NM_001099221	NP_001092691	Q6ZNK6	TIFAB_HUMAN	TIFA-related protein TIFAB	27											0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CTGCAGCCGTGGTGGGACATT	0.647													20	35					9.95505e-16	1.85953e-14	0.000295444	1	0
SPOCK1	6695	broad.mit.edu	37	5	136328235	136328235	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:136328235C>T	uc003lbo.2	-	6	835	c.644G>A	c.(643-645)GGA>GAA	p.G215E	SPOCK1_uc003lbp.2_Missense_Mutation_p.G215E	NM_004598	NP_004589	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains	215					cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTGGAGAGCTCCAAACCAATC	0.498													25	40					0	0	0.000878237	0	0
PCDHA7	56141	broad.mit.edu	37	5	140214949	140214949	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:140214949C>A	uc003lhq.2	+	1	981	c.981C>A	c.(979-981)TTC>TTA	p.F327L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.F327L	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	327	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATAAAGGCTTCCCACCCCTGG	0.478													16	32					7.21436e-19	1.53596e-17	0.000132079	1	0
PCDHB4	56131	broad.mit.edu	37	5	140503919	140503919	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:140503919G>T	uc003lip.1	+	1	2339	c.2339G>T	c.(2338-2340)AGG>ATG	p.R780M		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	780	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GACACCGGGAGGGAAGTTAAG	0.448													23	29					1.55469e-16	3.00321e-15	0.00047179	1	0
HDAC3	8841	broad.mit.edu	37	5	141016144	141016144	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:141016144G>T	uc003llf.2	-	2	175	c.109C>A	c.(109-111)CTG>ATG	p.L37M	HDAC3_uc003lle.1_5'Flank|HDAC3_uc010jgd.1_Missense_Mutation_p.L37M|HDAC3_uc010jge.1_RNA|RELL2_uc003lli.2_5'Flank|RELL2_uc003llh.2_5'Flank|RELL2_uc003llg.2_5'Flank|RELL2_uc010jgf.2_5'Flank	NM_003883	NP_003874	O15379	HDAC3_HUMAN	histone deacetylase 3	37	Histone deacetylase.				anti-apoptosis|cellular lipid metabolic process|negative regulation of cell cycle|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|spindle assembly|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|spindle microtubule|transcriptional repressor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription corepressor activity|transcription factor binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Vorinostat(DB02546)	CCGTAATGCAGGACCAGGCTA	0.622													10	16					3.07112e-06	3.15886e-05	0.000978159	1	0
PCDH1	5097	broad.mit.edu	37	5	141236886	141236886	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:141236886G>T	uc003llp.2	-	4	3367	c.3250C>A	c.(3250-3252)CTG>ATG	p.L1084M		NM_032420	NP_115796	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 2 precursor	Error:Variant_position_missing_in_Q08174_after_alignment					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		TCCTCAGGCAGGGCCAGGGGA	0.627													10	22					1.08611e-07	1.2576e-06	0.000978159	1	0
ARHGAP26	23092	broad.mit.edu	37	5	142434087	142434087	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:142434087C>A	uc011dbj.1	+	15	1404	c.1369C>A	c.(1369-1371)CTA>ATA	p.L457I	ARHGAP26_uc003lmt.2_Missense_Mutation_p.L457I|ARHGAP26_uc003lmw.2_Missense_Mutation_p.L457I	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal	457	Rho-GAP.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAAGACCTACCTAAGGTAGGG	0.433													50	69					1.00776e-21	2.38965e-20	0.000781405	1	0
JAKMIP2	9832	broad.mit.edu	37	5	147020327	147020327	+	Silent	SNP	T	G	G			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:147020327T>G	uc003loq.1	-	9	1723	c.1341A>C	c.(1339-1341)TCA>TCC	p.S447S	JAKMIP2_uc011dbx.1_Silent_p.S405S|JAKMIP2_uc003lor.1_Silent_p.S447S|uc003lop.1_Intron|JAKMIP2_uc010jgo.1_Silent_p.S447S	NM_014790	NP_055605	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein	447						Golgi apparatus				large_intestine(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGCCATGGATGATGTCTCTG	0.423													17	29					0	0	0.000422831	0	0
ADRB2	154	broad.mit.edu	37	5	148207496	148207496	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:148207496G>T	uc003lpr.1	+	1	1341	c.1102G>T	c.(1102-1104)GTG>TTG	p.V368L	SH3TC2_uc003lpp.1_Intron	NM_000024	NP_000015	P07550	ADRB2_HUMAN	adrenergic, beta-2-, receptor, surface	368	Cytoplasmic.				activation of transmembrane receptor protein tyrosine kinase activity|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|endosome to lysosome transport|positive regulation of MAPKKK cascade|receptor-mediated endocytosis	endosome|integral to plasma membrane|lysosome|receptor complex	beta2-adrenergic receptor activity|norepinephrine binding|potassium channel regulator activity|protein homodimerization activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Alprenolol(DB00866)|Arformoterol(DB01274)|Bambuterol(DB01408)|Bisoprolol(DB00612)|Bitolterol(DB00901)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Clenbuterol(DB01407)|Desipramine(DB01151)|Epinephrine(DB00668)|Fenoterol(DB01288)|Formoterol(DB00983)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Nadolol(DB01203)|Norepinephrine(DB00368)|Orciprenaline(DB00816)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Pirbuterol(DB01291)|Procaterol(DB01366)|Propranolol(DB00571)|Pseudoephedrine(DB00852)|Ritodrine(DB00867)|Salbutamol(DB01001)|Salmeterol(DB00938)|Terbutaline(DB00871)|Timolol(DB00373)	TGGATATCACGTGGAACAGGA	0.517													11	36					1.33987e-11	2.00981e-10	0.000673444	1	0
ZNF300	91975	broad.mit.edu	37	5	150275222	150275222	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:150275222C>A	uc003lsy.1	-	6	1846	c.1579G>T	c.(1579-1581)GGG>TGG	p.G527W	IRGM_uc011dcl.1_Intron	NM_052860	NP_443092	Q96RE9	ZN300_HUMAN	zinc finger protein 300	527	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGGCTTTCCCACATTCAGTA	0.433													16	25					1.02788e-11	1.5536e-10	0.000566183	1	0
TNIP1	10318	broad.mit.edu	37	5	150439957	150439957	+	Splice_Site	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:150439957C>A	uc003ltf.2	-	5	947	c.358_splice	c.e5-1	p.G120_splice	TNIP1_uc010jhl.2_Splice_Site|TNIP1_uc010jhm.2_Splice_Site_p.G120_splice|TNIP1_uc010jhn.2_Splice_Site_p.G120_splice|TNIP1_uc011dco.1_Splice_Site_p.G120_splice|TNIP1_uc003lth.2_Splice_Site|TNIP1_uc003lti.2_Splice_Site_p.G120_splice|TNIP1_uc003ltg.2_Splice_Site_p.G67_splice|TNIP1_uc003ltj.2_Splice_Site_p.G120_splice|TNIP1_uc010jho.1_Splice_Site|TNIP1_uc010jhq.1_Splice_Site_p.G67_splice|TNIP1_uc010jhp.1_Splice_Site_p.G67_splice|TNIP1_uc010jhr.1_Splice_Site_p.G120_splice|TNIP1_uc003ltk.2_Splice_Site_p.G120_splice	NM_006058	NP_006049	Q15025	TNIP1_HUMAN	TNFAIP3 interacting protein 1						defense response|glycoprotein biosynthetic process|negative regulation of viral genome replication|translation	cytoplasm|nucleus	protein binding			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.0911)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGGAGGTGCCCTGTGCAGAAA	0.577													18	22					1.01871e-10	1.4723e-09	0.000132079	1	0
SLIT3	6586	broad.mit.edu	37	5	168180101	168180101	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:168180101A>C	uc003mab.2	-	18	2252	c.1832T>G	c.(1831-1833)ATG>AGG	p.M611R	SLIT3_uc010jjg.2_Missense_Mutation_p.M611R	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	611	LRR 15.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACTCCTCAGCATCCTACAGGG	0.527													4	12					0	0	3.59834e-05	0	0
STC2	8614	broad.mit.edu	37	5	172744956	172744956	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:172744956G>T	uc003mco.1	-	4	2113	c.803C>A	c.(802-804)CCA>CAA	p.P268Q	STC2_uc003mcn.1_Missense_Mutation_p.P183Q	NM_003714	NP_003705	O76061	STC2_HUMAN	stanniocalcin 2 precursor	268					cell surface receptor linked signaling pathway|cell-cell signaling	extracellular region	hormone activity			skin(2)|ovary(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.223)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			ATGGGCGTTTGGGTGGCTCTT	0.637													22	43					1.55469e-16	3.00321e-15	0.00047179	1	0
C6orf15	29113	broad.mit.edu	37	6	31079834	31079834	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr6:31079834G>A	uc003nsk.1	-	2	302	c.302C>T	c.(301-303)TCG>TTG	p.S101L	PSORS1C1_uc003nsl.1_5'Flank|PSORS1C1_uc010jsj.1_5'Flank	NM_014070	NP_054789	Q6UXA7	CF015_HUMAN	STG protein precursor	101											0						CAGCCCCCACGATGGAGGCCA	0.617													23	44					0	0	0.000229342	0	0
TNXB	7148	broad.mit.edu	37	6	32062857	32062857	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr6:32062857G>T	uc003nzl.2	-	4	2556	c.2354C>A	c.(2353-2355)CCC>CAC	p.P785H		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TCTCACCGTGGGGATGAACTG	0.587													9	265					3.86212e-05	0.00036853	0.000673444	1	0
TNXB	7148	broad.mit.edu	37	6	32062930	32062931	+	Nonsense_Mutation	DNP	CC	AA	AA			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr6:32062930_32062931CC>AA	uc003nzl.2	-	4	2482_2483	c.2280_2281GG>TT	c.(2278-2283)TTGGAG>TTTTAG	p.760_761LE>F*		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GTTGTCTCCTCCAAGAGATGCA	0.579													12	382					0	0	6.4e-05	0	0
COL11A2	1302	broad.mit.edu	37	6	33145910	33145910	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr6:33145910G>T	uc003ocx.1	-	21	2099	c.1871C>A	c.(1870-1872)CCT>CAT	p.P624H	COL11A2_uc010jul.1_5'Flank|COL11A2_uc003ocy.1_Missense_Mutation_p.P538H|COL11A2_uc003ocz.1_Missense_Mutation_p.P517H	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	624	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						GTCACTTACAGGGGGTCCAGG	0.577													28	22					1.08312e-15	2.01369e-14	0.000279167	1	0
PEX6	5190	broad.mit.edu	37	6	42934283	42934283	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr6:42934283G>T	uc003otf.2	-	10	2167	c.2074C>A	c.(2074-2076)CAG>AAG	p.Q692K	PEX6_uc010jya.2_RNA	NM_000287	NP_000278	Q13608	PEX6_HUMAN	peroxisomal biogenesis factor 6	692					protein import into peroxisome matrix, translocation|protein stabilization	cytosol|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)	1			all cancers(41;0.00235)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0562)			CCAACGGCCTGGGAGTGAGCT	0.602													21	62					6.33239e-15	1.15029e-13	0.000175454	1	0
CRISP3	10321	broad.mit.edu	37	6	49701443	49701443	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr6:49701443G>T	uc003ozs.2	-	5	411	c.396C>A	c.(394-396)CCC>CCA	p.P132P		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	132					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			CCACTGCGTTGGGAGTCTTTG	0.403													36	35					1.07637e-12	1.71871e-11	0.000953801	1	0
COL19A1	1310	broad.mit.edu	37	6	70647929	70647929	+	Splice_Site	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr6:70647929G>T	uc003pfc.1	+	9	991	c.874_splice	c.e9-1	p.G292_splice	COL19A1_uc010kam.1_Splice_Site_p.G188_splice	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor						cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						TTTTTGCTCAGGGAGAAGCAG	0.428													22	37					3.6726e-16	6.95861e-15	0.000586117	1	0
MYO6	4646	broad.mit.edu	37	6	76540194	76540194	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr6:76540194C>T	uc003pih.1	+	5	602	c.323C>T	c.(322-324)TCT>TTT	p.S108F	MYO6_uc003pig.1_Missense_Mutation_p.S108F|MYO6_uc003pii.1_Missense_Mutation_p.S108F	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	108	Myosin head-like.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		AAAATATATTCTTCAGAAGCA	0.308													40	81					0	0	0.000270559	0	0
HTR1B	3351	broad.mit.edu	37	6	78172118	78172118	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr6:78172118G>T	uc003pil.1	-	1	1003	c.1003C>A	c.(1003-1005)CTA>ATA	p.L335I		NM_000863	NP_000854	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B	335	Helical; Name=6; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity				0		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)	GGCATCACTAGGGAGATGATG	0.498													13	56					3.27435e-08	3.95318e-07	0.000219431	1	0
CGA	1081	broad.mit.edu	37	6	87796111	87796111	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr6:87796111G>T	uc003plj.1	-	3	231	c.130C>A	c.(130-132)CAG>AAG	p.Q44K		NM_000735	NP_000726	P01215	GLHA_HUMAN	glycoprotein hormones, alpha polypeptide	44					hormone biosynthetic process|peptide hormone processing|signal transduction	extracellular region|soluble fraction	hormone activity			ovary(1)	1		all_cancers(76;5.98e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000102)		BRCA - Breast invasive adenocarcinoma(108;0.0484)		GCACCCGGCTGGGAGAAGAAT	0.448													28	56					1.39806e-14	2.48265e-13	0.000227799	1	0
ROS1	6098	broad.mit.edu	37	6	117609814	117609814	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr6:117609814C>A	uc003pxp.1	-	43	7084	c.6885G>T	c.(6883-6885)CAG>CAT	p.Q2295H	ROS1_uc011ebi.1_RNA	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	2295	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		ATTCAGATTCCTGGGAGCCTA	0.453			T	GOPC|ROS1	glioblastoma|NSCLC								33	15					4.92203e-23	1.24944e-21	0.000228196	1	0
RNF146	81847	broad.mit.edu	37	6	127607950	127607950	+	Silent	SNP	T	G	G			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr6:127607950T>G	uc003qav.2	+	3	351	c.192T>G	c.(190-192)GCT>GCG	p.A64A	RNF146_uc003qat.2_Silent_p.A63A|RNF146_uc003qau.2_Silent_p.A63A|RNF146_uc003qaw.2_Silent_p.A63A	NM_030963	NP_112225	Q9NTX7	RN146_HUMAN	ring finger protein 146	64	RING-type.				positive regulation of canonical Wnt receptor signaling pathway|protein autoubiquitination|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol	poly-ADP-D-ribose binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)	1				GBM - Glioblastoma multiforme(226;0.0407)|all cancers(137;0.2)		TAAAAGGAGCTTCATGGCTTG	0.463													25	14					0	0	0.000720815	0	0
MOXD1	26002	broad.mit.edu	37	6	132649618	132649618	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr6:132649618G>T	uc003qdf.2	-	5	878	c.779C>A	c.(778-780)CCC>CAC	p.P260H	MOXD1_uc003qde.2_Missense_Mutation_p.P192H	NM_015529	NP_056344	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1 isoform 2	260	Lumenal (Potential).				catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			ovary(1)	1	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		GGGCATGTTGGGGTGATAGCA	0.502													9	4					2.17888e-05	0.000211999	0.000442599	1	0
RAET1G	353091	broad.mit.edu	37	6	150239517	150239517	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr6:150239517G>T	uc010kii.1	-	4	703	c.635C>A	c.(634-636)CCA>CAA	p.P212Q	uc003qni.1_Intron|RAET1G_uc003qnm.2_Intron	NM_001001788	NP_001001788	Q6H3X3	RET1G_HUMAN	retinoic acid early transcript 1G precursor	212	Extracellular (Potential).				antigen processing and presentation|immune response	integral to membrane|MHC class I protein complex	protein binding				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.73e-12)		CATGGTGGGTGGTGCTGAAAT	0.587													9	11					3.09899e-07	3.48636e-06	0.000274275	1	0
EIF3B	8662	broad.mit.edu	37	7	2418774	2418774	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr7:2418774G>T	uc003slx.2	+	17	2321	c.2238G>T	c.(2236-2238)TTG>TTT	p.L746F	EIF3B_uc003sly.2_Missense_Mutation_p.L746F|EIF3B_uc003sma.2_Missense_Mutation_p.L474F|EIF3B_uc003smb.2_RNA	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	746					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		CATAGGAATTGGTGGAGAGAA	0.557													7	14					2.52707e-12	3.93984e-11	0.000442599	1	0
GLCCI1	113263	broad.mit.edu	37	7	8126022	8126023	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr7:8126022_8126023CG>AT	uc003srk.2	+	8	2057_2058	c.1498_1499CG>AT	c.(1498-1500)CGG>ATG	p.R500M		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	500											0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		GCTCTCATCCCGGGTTTCCTTT	0.574													6	175					0	0	6.4e-05	0	0
EGFR	1956	broad.mit.edu	37	7	55272965	55272965	+	Silent	SNP	C	A	A	rs143770509		TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr7:55272965C>A	uc003tqk.2	+	28	3534	c.3288C>A	c.(3286-3288)TCC>TCA	p.S1096S	EGFR_uc011kco.1_Silent_p.S1043S	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	1096	Cytoplasmic (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TAAACCAGTCCGTTCCCAAAA	0.383		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			9	17					2.74318e-10	3.85212e-09	0.000442599	1	0
ELN	2006	broad.mit.edu	37	7	73452041	73452041	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr7:73452041G>T	uc003tzw.2	+	4	259	c.168G>T	c.(166-168)CTG>CTT	p.L56L	RFC2_uc011kfa.1_Intron|ELN_uc003tzm.1_RNA|ELN_uc011kfe.1_Silent_p.L56L|ELN_uc003tzn.2_Silent_p.L56L|ELN_uc003tzz.2_Silent_p.L56L|ELN_uc003tzo.2_Silent_p.L56L|ELN_uc003tzp.2_Silent_p.L46L|ELN_uc003tzq.2_Silent_p.L56L|ELN_uc003tzr.2_RNA|ELN_uc003tzs.2_Silent_p.L56L|ELN_uc003tzt.2_Silent_p.L56L|ELN_uc003tzu.2_Silent_p.L56L|ELN_uc003tzv.2_Silent_p.L46L|ELN_uc003tzx.2_Silent_p.L46L|ELN_uc011kff.1_Silent_p.L56L|ELN_uc003tzy.2_Silent_p.L46L	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	56					blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	CTGCAGCGCTGGGGCCTGGAG	0.592			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						10	14					6.40141e-05	0.000605002	0.000978159	1	0
PION	54103	broad.mit.edu	37	7	77010642	77010642	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr7:77010642G>T	uc003ugf.2	-	8	635	c.556C>A	c.(556-558)CAA>AAA	p.Q186K	PION_uc003ugg.1_5'UTR	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	186					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						CCATCTTCTTGGGCGACATGG	0.299													12	37					7.03913e-09	8.93428e-08	0.00010058	1	0
PCLO	27445	broad.mit.edu	37	7	82582386	82582386	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr7:82582386G>T	uc003uhx.2	-	5	8172	c.7883C>A	c.(7882-7884)GCT>GAT	p.A2628D	PCLO_uc003uhv.2_Missense_Mutation_p.A2628D|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2559					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AATTTCTACAGCTGTCACAGG	0.448													14	74					3.27435e-08	3.95318e-07	0.000219431	1	0
MUC17	140453	broad.mit.edu	37	7	100687039	100687039	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr7:100687039C>A	uc003uxp.1	+	3	12395	c.12342C>A	c.(12340-12342)CCC>CCA	p.P4114P	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4114	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCGCTGTCCCCACGAATACTA	0.473													19	26					2.4624e-09	3.21818e-08	0.000132079	1	0
CUX1	1523	broad.mit.edu	37	7	101870822	101870822	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr7:101870822C>A	uc003uyx.3	+	21	3344	c.3306C>A	c.(3304-3306)CCC>CCA	p.P1102P	CUX1_uc003uys.3_Silent_p.P1113P|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	1102					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						ACTCCCAGCCCACAACCCCGC	0.647													7	19					0.000157383	0.00142617	0.000157383	1	0
TSPAN12	23554	broad.mit.edu	37	7	120478967	120478967	+	Splice_Site	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr7:120478967C>A	uc003vjk.2	-	4	524	c.150_splice	c.e4-1	p.R50_splice		NM_012338	NP_036470	O95859	TSN12_HUMAN	transmembrane 4 superfamily member 12						angiogenesis|cell surface receptor linked signaling pathway|regulation of angiogenesis|retina layer formation	integral to plasma membrane|membrane fraction					0	all_neural(327;0.117)					TTCCTCTACCCTGAAAGAAGA	0.348													36	64					1.02151e-06	1.09625e-05	0.000491102	1	0
NUP205	23165	broad.mit.edu	37	7	135302386	135302386	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr7:135302386C>A	uc003vsw.2	+	27	3758	c.3727C>A	c.(3727-3729)CTT>ATT	p.L1243I	NUP205_uc003vsx.2_5'Flank	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1243					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						AGTAAATGCCCTTCAGGGTAT	0.398													18	30					3.5997e-14	6.22481e-13	0.000295444	1	0
KIAA1549	57670	broad.mit.edu	37	7	138603046	138603046	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr7:138603046C>A	uc011kql.1	-	2	1375	c.1326G>T	c.(1324-1326)GTG>GTT	p.V442V	KIAA1549_uc003vuk.3_Silent_p.V392V|KIAA1549_uc011kqj.1_Silent_p.V442V	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	442						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						CCCCTGATCCCACGTCTTTCT	0.547			O	BRAF	pilocytic astrocytoma								22	51					4.26978e-12	6.57911e-11	0.00047179	1	0
TRY6	154754	broad.mit.edu	37	7	142480004	142480004	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr7:142480004C>A	uc011ksq.1	+	2	219	c.136C>A	c.(136-138)CAC>AAC	p.H46N	uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_RNA|uc003wan.1_Intron|TRY6_uc011kso.1_RNA|TRY6_uc011ksr.1_RNA	NR_001296				SubName: Full=Protease, serine, 3; Flags: Fragment;												0						TTCTGGCTCCCACTTCTGCGG	0.557													20	103					1.55795e-14	2.74198e-13	0.000229342	1	0
TAS2R39	259285	broad.mit.edu	37	7	142881285	142881285	+	Missense_Mutation	SNP	G	T	T	rs4103817		TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr7:142881285G>T	uc011ksw.1	+	1	774	c.774G>T	c.(772-774)ATG>ATT	p.M258I		NM_176881	NP_795362	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	258	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			skin(1)	1	Melanoma(164;0.059)					AGGCTCACATGGGGGCCATCA	0.493													36	50					2.05212e-20	4.72465e-19	0.00111076	1	0
OR2F2	135948	broad.mit.edu	37	7	143633062	143633062	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr7:143633062C>A	uc011ktv.1	+	1	737	c.737C>A	c.(736-738)ACG>AAG	p.T246K		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	246	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					TCTCACCTCACGGTGGTTGCC	0.517													22	27					7.87624e-14	1.35021e-12	0.000375601	1	0
ZNF425	155054	broad.mit.edu	37	7	148801090	148801090	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr7:148801090G>T	uc003wfj.2	-	4	1946	c.1873C>A	c.(1873-1875)CTG>ATG	p.L625M		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	625	C2H2-type 15.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TGGCTTTTCAGGTTTCCCTTG	0.537													21	90					1.87028e-06	1.96976e-05	0.000229342	1	0
ACTR3C	653857	broad.mit.edu	37	7	149981869	149981869	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr7:149981869G>T	uc003wgu.1	-	6	727	c.537C>A	c.(535-537)CCC>CCA	p.P179P		NM_001040135	NP_001035225	Q9C0K3	ARP3C_HUMAN	actin-related protein 3-beta isoform 2	179					regulation of actin filament polymerization	cytoskeleton	actin binding|ATP binding				0						GCACATCGATGGGGCAGTTCT	0.403													15	25					5.3912e-06	5.44622e-05	0.00074312	1	0
C7orf29	113763	broad.mit.edu	37	7	150027647	150027647	+	Silent	SNP	T	C	C			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr7:150027647T>C	uc003wgy.2	+	1	710	c.154T>C	c.(154-156)TTG>CTG	p.L52L	LRRC61_uc003wgv.2_Intron|LRRC61_uc003wgx.2_Intron|LRRC61_uc003wgw.2_Intron	NM_138434	NP_612443	Q96FA7	CG029_HUMAN	hypothetical protein LOC113763	52										ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.011)			GGCTGAGGGGTTGGCCCGGCA	0.607													36	68					0	0	0.000270559	0	0
CSMD1	64478	broad.mit.edu	37	8	2820092	2820092	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr8:2820092G>A	uc011kwk.1	-	61	9917	c.9527C>T	c.(9526-9528)TCC>TTC	p.S3176F	CSMD1_uc011kwj.1_Missense_Mutation_p.S2505F|CSMD1_uc010lrg.2_Missense_Mutation_p.S1067F	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3176	Extracellular (Potential).|Sushi 26.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GAAGACTTCGGACTTATAGGT	0.527													13	19					0	0	0.00010058	0	0
RP1L1	94137	broad.mit.edu	37	8	10465297	10465297	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr8:10465297G>T	uc003wtc.2	-	4	6540	c.6311C>A	c.(6310-6312)CCA>CAA	p.P2104Q		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	2104					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TTCTGCCTCTGGGGCCTCTAC	0.617													59	68					2.17656e-39	6.78674e-38	0.000781405	1	0
SLC39A14	23516	broad.mit.edu	37	8	22265865	22265865	+	Nonsense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr8:22265865G>T	uc003xbq.3	+	3	488	c.313G>T	c.(313-315)GAG>TAG	p.E105*	SLC39A14_uc011kzg.1_Nonsense_Mutation_p.E105*|SLC39A14_uc003xbp.3_Nonsense_Mutation_p.E105*|SLC39A14_uc011kzh.1_Nonsense_Mutation_p.E105*	NM_001128431	NP_001121903	Q15043	S39AE_HUMAN	solute carrier family 39 (zinc transporter),	105	Extracellular (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|lamellipodium|plasma membrane	zinc ion transmembrane transporter activity				0				Colorectal(74;0.019)|COAD - Colon adenocarcinoma(73;0.0731)		CAATTTCAGCGAGCAGTCGCG	0.592													24	41					1.42536e-11	2.12196e-10	0.000720815	1	0
NEFM	4741	broad.mit.edu	37	8	24771612	24771612	+	Silent	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr8:24771612G>A	uc003xed.3	+	1	339	c.306G>A	c.(304-306)AAG>AAA	p.K102K	NEFM_uc011lac.1_Silent_p.K102K|NEFM_uc010lue.2_5'Flank|uc010luc.1_3'UTR	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	102	Head.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		CCAACGAGAAGGAGCAGCTGC	0.632													6	13					0	0	0.000157383	0	0
TMEM66	51669	broad.mit.edu	37	8	29923607	29923607	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr8:29923607G>T	uc003xhs.2	-	5	1075	c.891C>A	c.(889-891)CCC>CCA	p.P297P	TMEM66_uc003xht.2_Silent_p.P297P|TMEM66_uc003xhu.2_Silent_p.P261P|TMEM66_uc003xhv.2_Silent_p.P125P	NM_016127	NP_057211	Q96BY9	TMM66_HUMAN	transmembrane protein 66 precursor	297						integral to membrane					0				KIRC - Kidney renal clear cell carcinoma(542;0.0993)|Kidney(114;0.119)		CAGGGTAGGAGGGAGGATAGG	0.478													12	39					4.36969e-10	5.98753e-09	0.000151284	1	0
CNGB3	54714	broad.mit.edu	37	8	87680367	87680367	+	Nonsense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr8:87680367C>A	uc003ydx.2	-	5	569	c.523G>T	c.(523-525)GAA>TAA	p.E175*	CNGB3_uc010maj.2_Nonsense_Mutation_p.E37*	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	175	Cytoplasmic (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						TCATCGCTTTCTTTTACTGGT	0.348													32	49					2.61193e-14	4.53651e-13	0.000279167	1	0
CNGB3	54714	broad.mit.edu	37	8	87738864	87738864	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr8:87738864G>A	uc003ydx.2	-	3	279	c.233C>T	c.(232-234)TCC>TTC	p.S78F		NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	78	Cytoplasmic (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						ATCTCCAGAGGAATTTTTCTT	0.428													73	142					0	0	0.000781405	0	0
TATDN1	83940	broad.mit.edu	37	8	125520735	125520735	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr8:125520735C>A	uc003yrd.2	-	8	538	c.496G>T	c.(496-498)GAT>TAT	p.D166Y	TATDN1_uc003yre.2_RNA|TATDN1_uc010mdm.2_Missense_Mutation_p.D119Y|TATDN1_uc003yrf.2_Missense_Mutation_p.D166Y	NM_032026	NP_114415	Q6P1N9	TATD1_HUMAN	TatD DNase domain containing 1 isoform a	166						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding				0	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			ACACACCGATCTCTATTTCTT	0.214													15	28					1.02788e-11	1.5536e-10	0.000566183	1	0
FLJ43860	389690	broad.mit.edu	37	8	142458048	142458048	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr8:142458048G>T	uc003ywi.2	-	23	2859	c.2778C>A	c.(2776-2778)CCC>CCA	p.P926P	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	926							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CCTGCTGCTTGGGCTAGGGCT	0.652													5	5					1.23904e-05	0.00012145	0.000602214	1	0
TOP1MT	116447	broad.mit.edu	37	8	144408405	144408405	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr8:144408405C>A	uc003yxz.2	-	4	489	c.470G>T	c.(469-471)AGG>ATG	p.R157M	TOP1MT_uc011lkd.1_Missense_Mutation_p.R59M|TOP1MT_uc011lke.1_Missense_Mutation_p.R59M|TOP1MT_uc010mfb.2_Missense_Mutation_p.R59M|TOP1MT_uc011lkf.1_5'Flank|TOP1MT_uc010mfd.1_Translation_Start_Site	NM_052963	NP_443195	Q969P6	TOP1M_HUMAN	mitochondrial topoisomerase I precursor	157					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	CTTCTCCTCCCTGCTCAGGAC	0.592													21	22					1.87028e-06	1.96976e-05	0.000229342	1	0
ADCK5	203054	broad.mit.edu	37	8	145617999	145617999	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr8:145617999G>T	uc003zch.2	+	14	1583	c.1529G>T	c.(1528-1530)CGG>CTG	p.R510L	ADCK5_uc003zcg.2_RNA|ADCK5_uc003zci.2_Missense_Mutation_p.R99L	NM_174922	NP_777582	Q3MIX3	ADCK5_HUMAN	aarF domain containing kinase 5	510						integral to membrane	protein serine/threonine kinase activity			stomach(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;8.96e-41)|Epithelial(56;4.08e-40)|all cancers(56;4.51e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			AGGGCTGTCCGGGGCTGGAGC	0.692													5	6					1.23904e-05	0.00012145	0.000602214	1	0
DMRTA1	63951	broad.mit.edu	37	9	22447217	22447217	+	Silent	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr9:22447217C>A	uc003zpp.1	+	1	378	c.153C>A	c.(151-153)CCC>CCA	p.P51P		NM_022160	NP_071443	Q5VZB9	DMRTA_HUMAN	DMRT-like family A1	51					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|skin(1)	2		all_cancers(5;4.09e-243)|Acute lymphoblastic leukemia(3;8.25e-150)|all_hematologic(3;4.25e-147)|Esophageal squamous(3;2.32e-09)|Renal(3;1.71e-07)|Breast(3;2.07e-06)|Hepatocellular(5;0.00563)		GBM - Glioblastoma multiforme(1;5.12e-278)|Lung(24;8.2e-52)|LUSC - Lung squamous cell carcinoma(38;1.46e-37)|OV - Ovarian serous cystadenocarcinoma(39;0.0517)		TGCGGCCGCCCAGCCTCTTTC	0.627													4	14					0.000602214	0.00527604	0.000602214	1	0
FBXO10	26267	broad.mit.edu	37	9	37521655	37521655	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr9:37521655C>A	uc004aab.2	-	8	2160	c.2111G>T	c.(2110-2112)TGG>TTG	p.W704L	FBXO10_uc004aac.2_Missense_Mutation_p.W720L|FBXO10_uc004aad.2_Missense_Mutation_p.W254L	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	704						ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)		CTCTGTCTCCCAGAGGATGGC	0.542													8	62					0.000274275	0.00244624	0.000274275	1	0
ZCCHC6	79670	broad.mit.edu	37	9	88916409	88916409	+	Missense_Mutation	SNP	C	A	A	rs76212915		TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr9:88916409C>A	uc004aoq.2	-	26	4417	c.4202G>T	c.(4201-4203)AGG>ATG	p.R1401M	ZCCHC6_uc010mqe.2_Missense_Mutation_p.R301M|ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Missense_Mutation_p.R1165M|ZCCHC6_uc004aou.2_Missense_Mutation_p.R1401M	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	1401					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						TGACACCTCCCTTTCTGTGTA	0.498													32	45					5.77227e-19	1.23558e-17	0.000227799	1	0
SHC3	53358	broad.mit.edu	37	9	91628367	91628367	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr9:91628367G>T	uc004aqg.2	-	12	2087	c.1780C>A	c.(1780-1782)CAG>AAG	p.Q594K		NM_016848	NP_058544	Q92529	SHC3_HUMAN	src homology 2 domain-containing transforming	594				KQ -> NE (in Ref. 2).	central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			lung(3)|skin(1)	4						CCAGGTCACTGCTTCCTCTCC	0.602													21	28					5.26018e-13	8.57214e-12	0.000229342	1	0
RNF20	56254	broad.mit.edu	37	9	104314989	104314989	+	Missense_Mutation	SNP	C	T	T	rs139776458	byFrequency	TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr9:104314989C>T	uc004bbn.2	+	13	1945	c.1855C>T	c.(1855-1857)CGG>TGG	p.R619W		NM_019592	NP_062538	Q5VTR2	BRE1A_HUMAN	ring finger protein 20	619	Potential.				histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(1)|breast(1)|kidney(1)|skin(1)	8		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		TGATGATGGACGGAAAAAGGA	0.284													27	25					0	0	0.000227799	0	0
OR13C9	286362	broad.mit.edu	37	9	107380171	107380171	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr9:107380171C>A	uc011lvr.1	-	1	315	c.315G>T	c.(313-315)TTG>TTT	p.L105F		NM_001001956	NP_001001956	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C,	105	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCCCCATGGCCAAGCCAAGGA	0.502													43	55					1.15505e-17	2.34564e-16	0.000437636	1	0
ZNF462	58499	broad.mit.edu	37	9	109687519	109687519	+	Silent	SNP	C	A	A	rs144393411		TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr9:109687519C>A	uc004bcz.2	+	3	1615	c.1326C>A	c.(1324-1326)CCC>CCA	p.P442P	ZNF462_uc010mto.2_Silent_p.P290P|ZNF462_uc004bda.2_Silent_p.P290P	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	442	C2H2-type 4.				transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						TCCAGTGCCCCTTTTGTCCTT	0.463													16	90					1.40151e-16	2.73398e-15	0.000175454	1	0
C9orf84	158401	broad.mit.edu	37	9	114470148	114470148	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr9:114470148C>A	uc004bfr.2	-	17	2488	c.2353G>T	c.(2353-2355)GGT>TGT	p.G785C	C9orf84_uc011lwt.1_RNA|C9orf84_uc004bfq.2_Missense_Mutation_p.G746C|C9orf84_uc010mug.2_Missense_Mutation_p.G696C	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	785										ovary(2)	2						CTTAAAACACCTTCAGATTCC	0.209													14	158					4.3838e-07	4.8627e-06	0.000151284	1	0
KIAA1958	158405	broad.mit.edu	37	9	115336503	115336503	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr9:115336503G>T	uc004bgf.1	+	2	318	c.143G>T	c.(142-144)TGG>TTG	p.W48L	KIAA1958_uc011lwx.1_Missense_Mutation_p.W48L	NM_133465	NP_597722	Q8N8K9	K1958_HUMAN	hypothetical protein LOC158405	48										skin(1)	1						ACAGCAATGTGGGGCTGTAGT	0.507													13	18					1.49906e-05	0.000146575	0.000219431	1	0
COL27A1	85301	broad.mit.edu	37	9	116931364	116931364	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr9:116931364C>A	uc011lxl.1	+	3	1529	c.1529C>A	c.(1528-1530)CCA>CAA	p.P510Q	COL27A1_uc004bii.2_RNA|COL27A1_uc010mvd.1_Missense_Mutation_p.P360Q	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	510	Pro-rich.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						ATGGTACCTCCAACTTCGGGC	0.582													34	57					3.6622e-26	9.86552e-25	0.000692331	1	0
AKNA	80709	broad.mit.edu	37	9	117122051	117122051	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr9:117122051G>T	uc004biq.3	-	10	2450	c.2315C>A	c.(2314-2316)CCA>CAA	p.P772Q	AKNA_uc004bin.3_Missense_Mutation_p.P19Q|AKNA_uc004bio.3_Missense_Mutation_p.P232Q|AKNA_uc004bip.3_Missense_Mutation_p.P691Q|AKNA_uc004bir.3_Missense_Mutation_p.P772Q|AKNA_uc004bis.3_Missense_Mutation_p.P772Q|AKNA_uc010mve.2_Missense_Mutation_p.P653Q|AKNA_uc004biu.1_Missense_Mutation_p.P513Q|AKNA_uc004biv.1_Missense_Mutation_p.P772Q	NM_030767	NP_110394	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	772	PEST.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(2)	6						CATGGCTTCTGGGAGAGACTT	0.453													6	9					5.9392e-07	6.51502e-06	3.59834e-05	1	0
MAN1B1	11253	broad.mit.edu	37	9	140000631	140000631	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr9:140000631G>T	uc004cld.2	+	9	1344	c.1309G>T	c.(1309-1311)GGG>TGG	p.G437W	MAN1B1_uc011meo.1_Missense_Mutation_p.G338W|MAN1B1_uc011mep.1_Missense_Mutation_p.G437W|MAN1B1_uc010ncc.2_RNA|MAN1B1_uc004clf.1_Missense_Mutation_p.G110W|MAN1B1_uc004clg.1_RNA	NM_016219	NP_057303	Q9UKM7	MA1B1_HUMAN	alpha 1,2-mannosidase	437	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(1)|central_nervous_system(1)	2	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		GAAGAAGGATGGGCTGGTGCC	0.607													9	13					3.86212e-05	0.00036853	0.000673444	1	0
TUBBP5	643224	broad.mit.edu	37	9	141070768	141070768	+	Silent	SNP	C	T	T	rs4609262	by1000genomes	TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr9:141070768C>T	uc004com.2	+	4	432	c.171C>T	c.(169-171)TGC>TGT	p.C57C	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						GCTGTGACTGCCTGCAGGGTT	0.617													3	6					0	0	0.000602214	0	0
FGD1	2245	broad.mit.edu	37	X	54472556	54472556	+	Silent	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chrX:54472556G>T	uc004dtg.2	-	18	3606	c.2872C>A	c.(2872-2874)CGA>AGA	p.R958R		NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	958					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						GTCTTGTCTCGGGTCTGGGGG	0.632													4	1					4.096e-09	5.28344e-08	3.59834e-05	1	0
KIF4A	24137	broad.mit.edu	37	X	69640028	69640028	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chrX:69640028G>T	uc004dyg.2	+	31	3739	c.3612G>T	c.(3610-3612)AAG>AAT	p.K1204N	KIF4A_uc010nkw.2_Missense_Mutation_p.K1204N|GDPD2_uc010nkx.1_5'Flank|GDPD2_uc010nky.1_5'Flank|GDPD2_uc004dyh.2_5'Flank|GDPD2_uc011mpk.1_5'Flank|GDPD2_uc011mpl.1_5'Flank|GDPD2_uc011mpm.1_5'Flank	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4	1204	Globular.|Interaction with PRC1.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4						AAGAAAACAAGGCTCCAGGGA	0.527													14	2					4.36969e-10	5.98753e-09	0.000151284	1	0
MAGT1	84061	broad.mit.edu	37	X	77130990	77130991	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chrX:77130990_77130991CG>AT	uc004fof.2	-	2	364_365	c.302_303CG>AT	c.(301-303)CCG>CAT	p.P101H	MAGT1_uc004fog.3_RNA|MAGT1_uc004ect.3_Missense_Mutation_p.P101H	NM_032121	NP_115497	Q9H0U3	MAGT1_HUMAN	magnesium transporter 1	69					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				upper_aerodigestive_tract(1)	1						AGTAATTTCTCGGTGGGGCTTT	0.411													6	100					0	0	6.4e-05	0	0
PCDH19	57526	broad.mit.edu	37	X	99661580	99661580	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chrX:99661580C>A	uc010nmz.2	-	1	3692	c.2016G>T	c.(2014-2016)ATG>ATT	p.M672I	PCDH19_uc004efw.3_Missense_Mutation_p.M672I|PCDH19_uc004efx.3_Missense_Mutation_p.M672I	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	672	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						TCACAGAGCCCATTGACTCTT	0.512													16	4					1.67942e-08	2.09795e-07	0.00074312	1	0
ARMCX1	51309	broad.mit.edu	37	X	100808228	100808228	+	Silent	SNP	G	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chrX:100808228G>A	uc004ehv.2	+	4	686	c.315G>A	c.(313-315)GAG>GAA	p.E105E	ARMCX1_uc004ehw.2_Silent_p.E105E	NM_016608	NP_057692	Q9P291	ARMX1_HUMAN	armadillo repeat containing, X-linked 1	105						integral to membrane	binding	p.E105Q(1)		ovary(3)|pancreas(1)	4						GTGGCCTAGAGGCCAAGGCCA	0.567													17	9					0	0	0.000958276	0	0
NXF3	56000	broad.mit.edu	37	X	102337259	102337259	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chrX:102337259C>A	uc004eju.2	-	9	885	c.814G>T	c.(814-816)GGG>TGG	p.G272W	NXF3_uc010noi.1_Missense_Mutation_p.G122W|NXF3_uc011mrw.1_Missense_Mutation_p.G272W|NXF3_uc011mrx.1_Missense_Mutation_p.G183W	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	272						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						GGCTCTATCCCTTTCCACTTG	0.547													47	13					2.0833e-19	4.55794e-18	0.000781405	1	0
ZNF75D	7626	broad.mit.edu	37	X	134427680	134427680	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chrX:134427680C>A	uc004eyp.2	-	3	3042	c.387G>T	c.(385-387)AGG>AGT	p.R129S	ZNF75D_uc004eym.2_Intron|ZNF75D_uc004eyn.2_5'Flank|ZNF75D_uc004eyo.2_Missense_Mutation_p.R129S	NM_007131	NP_009062	P51815	ZN75D_HUMAN	zinc finger protein 75	129	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CATCAGGCTCCCTCTGCAAGA	0.453													65	8					3.13743e-37	9.63118e-36	0.000781405	1	0
PNMA3	29944	broad.mit.edu	37	X	152225667	152225667	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chrX:152225667G>T	uc004fhc.2	+	2	591	c.255G>T	c.(253-255)AAG>AAT	p.K85N	PNMA5_uc004fha.3_5'Flank|PNMA3_uc004fhd.2_5'Flank	NM_013364	NP_037496	Q9UL41	PNMA3_HUMAN	paraneoplastic cancer-testis-brain antigen	85					apoptosis	nucleolus	nucleic acid binding|zinc ion binding			skin(2)|large_intestine(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					taccaggaaagggggggccct	0													13	6					3.52763e-06	3.60037e-05	0.000566183	1	0
KIAA0907	22889	broad.mit.edu	37	1	155886422	155886423	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr1:155886422_155886423delCT	uc001fmi.1	-	12	1570_1571	c.1546_1547delAG	c.(1546-1548)AGGfs	p.R516fs	KIAA0907_uc001fmj.1_Frame_Shift_Del_p.R516fs|KIAA0907_uc009wrk.1_Frame_Shift_Del_p.R373fs|KIAA0907_uc009wrl.1_RNA	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	516											0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			TTACCTGTCCCTCTCTCTCTCT	0.396													8	403	---	---	---	---					
ANO1	55107	broad.mit.edu	37	11	69934084	69934084	+	Frame_Shift_Del	DEL	C	-	-			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr11:69934084delC	uc001opj.2	+	2	640	c.335delC	c.(334-336)TCGfs	p.S112fs	ANO1_uc001opk.1_Frame_Shift_Del_p.S84fs|ANO1_uc001opl.1_RNA	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	112	Cytoplasmic (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						GATGCAGGCTCGGGGGAGCCC	0.701													2	4	---	---	---	---					
SYMPK	8189	broad.mit.edu	37	19	46330795	46330797	+	In_Frame_Del	DEL	GAG	-	-			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr19:46330795_46330797delGAG	uc002pdn.2	-	16	2397_2399	c.2152_2154delCTC	c.(2152-2154)CTCdel	p.L718del	SYMPK_uc002pdo.1_In_Frame_Del_p.L718del|SYMPK_uc002pdp.1_In_Frame_Del_p.L718del	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	718					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		AGCTGAGGTCGAGGAGGACATGC	0.581													8	33	---	---	---	---					
AP3B1	8546	broad.mit.edu	37	5	77536740	77536741	+	Frame_Shift_Ins	INS	-	T	T			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr5:77536740_77536741insT	uc003kfj.2	-	3	349_350	c.224_225insA	c.(223-225)AATfs	p.N75fs		NM_003664	NP_003655	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1	75					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		GTTCAGATGCATTTTTCCCTTT	0.297									Hermansky-Pudlak_syndrome				93	123	---	---	---	---					
MATN2	4147	broad.mit.edu	37	8	99028877	99028877	+	Frame_Shift_Del	DEL	A	-	-			TCGA-EE-A184-06A-11D-A196-08	TCGA-EE-A184-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d1833d8-7e02-4331-97b7-6e2fb956975f	a40649f4-7c99-409c-9951-3121476deb04	g.chr8:99028877delA	uc003yic.2	+	11	1914	c.1683delA	c.(1681-1683)GGAfs	p.G561fs	MATN2_uc010mbh.1_Frame_Shift_Del_p.G520fs|MATN2_uc003yid.2_Frame_Shift_Del_p.G561fs|MATN2_uc003yie.1_Frame_Shift_Del_p.G561fs|MATN2_uc010mbi.1_Frame_Shift_Del_p.G394fs|MATN2_uc010mbj.1_Frame_Shift_Del_p.G60fs	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	561	EGF-like 8.					proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			GTGAAGATGGAAAAACCTGCA	0.453													3	4	---	---	---	---					
