Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SDF4	51150	broad.mit.edu	37	1	1153955	1153955	+	Silent	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr1:1153955G>A	uc001adh.3	-	6	1124	c.795C>T	c.(793-795)ACC>ACT	p.T265T	SDF4_uc001adg.2_RNA|SDF4_uc001adi.3_Silent_p.T265T|SDF4_uc009vjv.2_Silent_p.T143T|SDF4_uc009vjw.2_RNA	NM_016176	NP_057260	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4 isoform 2	265	EF-hand 4.				cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|calcium ion binding|identical protein binding|protein binding			upper_aerodigestive_tract(1)|large_intestine(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		GGTTCTCCACGGTGCCCACGG	0.592000													9	21					0	0	0.000274275	0	0
MST1P2	11209	broad.mit.edu	37	1	16975289	16975289	+	Splice_Site	SNP	T	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr1:16975289T>A	uc010och.1	+	8		c.1656_splice	c.e8+2		MST1P2_uc001azl.3_Splice_Site|MST1P2_uc009vox.2_Splice_Site|MST1P2_uc001azm.3_RNA	NR_027504				Homo sapiens cDNA FLJ43241 fis, clone HEART1000010, weakly  similar to Hepatocyte growth factor-like protein precursor.												0						CCCCCCCAGGTTAGGAGTTGG	0.577000													11	88					0	0	0.000978159	0	0
ZNF436	80818	broad.mit.edu	37	1	23689214	23689214	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr1:23689214G>A	uc001bgt.2	-	3	1042	c.661C>T	c.(661-663)CCT>TCT	p.P221S	ZNF436_uc001bgu.2_Missense_Mutation_p.P221S	NM_030634	NP_085137	Q9C0F3	ZN436_HUMAN	zinc finger protein 436	221					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;5.97e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000977)|KIRC - Kidney renal clear cell carcinoma(1967;0.00336)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		CATTTGTGAGGCTTCTCTCCA	0.463000													19	56					0	0	0.000175454	0	0
AKNAD1	254268	broad.mit.edu	37	1	109363229	109363229	+	Silent	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr1:109363229C>T	uc001dwa.2	-	14	2456	c.2187G>A	c.(2185-2187)CGG>CGA	p.R729R	AKNAD1_uc001dwb.2_Intron	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	729										ovary(3)	3						GAGAACAGATCCGTTTGGGTT	0.333000													12	40					0	0	0.000151284	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	G	G	rs9424867		TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr1:145302714A>G	uc001end.3	+	8	1187	c.1152A>G	c.(1150-1152)TTA>TTG	p.L384L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_5'UTR|NBPF10_uc001emq.1_Silent_p.L113L	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527000													4	44					0	0	0.000602214	0	0
S100A7A	338324	broad.mit.edu	37	1	153391621	153391621	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr1:153391621G>A	uc001fbt.1	+	3	199	c.142G>A	c.(142-144)GAC>AAC	p.D48N		NM_176823	NP_789793	Q86SG5	S1A7A_HUMAN	S100 calcium binding protein A7-like 1	48	EF-hand 1.					cytoplasm	calcium ion binding			skin(1)	1	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTCTTCACAGGACAAAAAGGG	0.408000													6	22					0	0	3.59834e-05	0	0
RPL31P11	641311	broad.mit.edu	37	1	161654957	161654957	+	RNA	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr1:161654957G>A	uc001gbc.2	-	1		c.86C>T				NR_002595				Homo sapiens cDNA clone IMAGE:6574909, containing frame-shift errors.												0						GTTGATGGCAGAACGGCCCTT	0.547000													6	9					0	0	3.59834e-05	0	0
FMO2	2327	broad.mit.edu	37	1	171162617	171162617	+	Silent	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr1:171162617G>A	uc001ghk.1	+	3	393	c.276G>A	c.(274-276)AGG>AGA	p.R92R	FMO2_uc010pmd.1_5'UTR	NM_001460	NP_001451	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2	92					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AATATTTCAGGATTTTTGCTA	0.338000													11	25					0	0	0.00010058	0	0
TNR	7143	broad.mit.edu	37	1	175362984	175362984	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr1:175362984T>C	uc001gkp.1	-	4	1369	c.1288A>G	c.(1288-1290)ACC>GCC	p.T430A	TNR_uc009wwu.1_Missense_Mutation_p.T430A|TNR_uc010pmz.1_3'UTR	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	430	Fibronectin type-III 2.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					ACCTCCACGGTGGTCTCTGTG	0.493000													11	99					0	0	0.000673444	0	0
ABL2	27	broad.mit.edu	37	1	179100501	179100501	+	Silent	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr1:179100501G>A	uc001gmj.3	-	3	623	c.336C>T	c.(334-336)TTC>TTT	p.F112F	ABL2_uc010pnf.1_Silent_p.F112F|ABL2_uc010png.1_Silent_p.F91F|ABL2_uc010pnh.1_Silent_p.F91F|ABL2_uc009wxe.2_Silent_p.F91F|ABL2_uc001gmg.3_Silent_p.F97F|ABL2_uc001gmi.3_Silent_p.F97F|ABL2_uc001gmh.3_Silent_p.F76F|ABL2_uc010pne.1_Silent_p.F76F|ABL2_uc009wxf.1_Silent_p.F97F|ABL2_uc001gmk.2_Silent_p.F76F	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	112	SH3.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	AAAGTGCAACGAAGAGATTAG	0.443000			T	ETV6	AML								5	19					0	0	0.000602214	0	0
CEP350	9857	broad.mit.edu	37	1	179989667	179989667	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr1:179989667A>G	uc001gnt.2	+	12	3141	c.2758A>G	c.(2758-2760)AAA>GAA	p.K920E	CEP350_uc009wxl.2_Missense_Mutation_p.K919E|CEP350_uc001gnu.2_Missense_Mutation_p.K754E	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	920						centrosome|nucleus|spindle				ovary(4)	4						TAGTGAATTTAAAAAGCTTCC	0.428000													12	31					0	0	0.00010058	0	0
LAMB3	3914	broad.mit.edu	37	1	209805978	209805978	+	Missense_Mutation	SNP	G	A	A	rs145575474		TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr1:209805978G>A	uc001hhg.2	-	7	1162	c.772C>T	c.(772-774)CGC>TGC	p.R258C	LAMB3_uc009xco.2_Missense_Mutation_p.R258C|LAMB3_uc001hhh.2_Missense_Mutation_p.R258C|LAMB3_uc010psl.1_RNA|LAMB3_uc009xcp.1_Missense_Mutation_p.R194C	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	258	Laminin EGF-like 1.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GGTGCGCAGCGATCAGCATGG	0.677000													10	28					0	0	0.000978159	0	0
VASH2	79805	broad.mit.edu	37	1	213134585	213134585	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr1:213134585G>A	uc001hjy.2	+	2	558	c.354G>A	c.(352-354)ATG>ATA	p.M118I	VASH2_uc001hju.2_Missense_Mutation_p.M118I|VASH2_uc001hjv.2_RNA|VASH2_uc001hjx.2_Missense_Mutation_p.M53I|VASH2_uc010ptn.1_Missense_Mutation_p.M14I|VASH2_uc001hjw.2_Missense_Mutation_p.M118I	NM_001136475	NP_001129947	Q86V25	VASH2_HUMAN	vasohibin 2 isoform 3	118					positive regulation of angiogenesis|positive regulation of endothelial cell proliferation	cytoplasm					0				OV - Ovarian serous cystadenocarcinoma(81;0.00479)|all cancers(67;0.00844)|GBM - Glioblastoma multiforme(131;0.0496)|Epithelial(68;0.0986)		AGAATTACATGAAGACCCTAC	0.542000													23	83					0	0	0.00047179	0	0
USH2A	7399	broad.mit.edu	37	1	216420487	216420487	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr1:216420487T>C	uc001hku.1	-	13	2636	c.2249A>G	c.(2248-2250)AAC>AGC	p.N750S	USH2A_uc001hkv.2_Missense_Mutation_p.N750S	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	750	Laminin EGF-like 5.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GCCATGGAGGTTACACTGGCA	0.413000										HNSCC(13;0.011)			24	64					0	0	0.000586117	0	0
ITIH5	80760	broad.mit.edu	37	10	7679332	7679332	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr10:7679332C>T	uc001ijq.2	-	5	590	c.511G>A	c.(511-513)GAG>AAG	p.E171K	ITIH5_uc001ijr.1_Missense_Mutation_p.E171K	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	171					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						ATGCTGTGCTCGTACTTGCCC	0.592000													6	36					0	0	3.59834e-05	0	0
ANK3	288	broad.mit.edu	37	10	61819111	61819111	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr10:61819111G>A	uc001jky.2	-	41	12865	c.12673C>T	c.(12673-12675)CGA>TGA	p.R4225*	ANK3_uc001jkw.2_Nonsense_Mutation_p.R849*|ANK3_uc009xpa.2_Nonsense_Mutation_p.R849*|ANK3_uc001jkx.2_Nonsense_Mutation_p.R893*|ANK3_uc010qih.1_Nonsense_Mutation_p.R1716*|ANK3_uc001jkz.3_Nonsense_Mutation_p.R1709*|ANK3_uc001jkv.2_Nonsense_Mutation_p.R248*	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	4225					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TCATCCAGTCGATCTAGTAAC	0.398000													9	72					0	0	0.000442599	0	0
C10orf120	399814	broad.mit.edu	37	10	124457771	124457771	+	Silent	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr10:124457771C>T	uc001lgn.2	-	3	518	c.486G>A	c.(484-486)GTG>GTA	p.V162V		NM_001010912	NP_001010912	Q5SQS8	CJ120_HUMAN	hypothetical protein LOC399814	162										kidney(1)	1		all_neural(114;0.169)|Glioma(114;0.222)				TACTGACGTTCACCTGCTCTC	0.468000													12	76					0	0	0.00010058	0	0
BRSK2	9024	broad.mit.edu	37	11	1467078	1467078	+	Silent	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr11:1467078G>A	uc001lti.2	+	12	1553	c.1167G>A	c.(1165-1167)ACG>ACA	p.T389T	BRSK2_uc009ycv.1_Silent_p.T389T|BRSK2_uc001lth.1_Silent_p.T389T|BRSK2_uc001ltj.2_Silent_p.T389T|BRSK2_uc001ltk.2_RNA|BRSK2_uc001ltl.2_Silent_p.T389T|BRSK2_uc001ltm.2_Silent_p.T435T|BRSK2_uc001ltn.2_RNA|BRSK2_uc010qwx.1_RNA	NM_003957	NP_003948	Q8IWQ3	BRSK2_HUMAN	BR serine/threonine kinase 2	389					establishment of cell polarity|neuron differentiation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0		all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00144)|Lung(200;0.0713)|LUSC - Lung squamous cell carcinoma(625;0.0842)		TCAGCGTGACGGACGGCGGCT	0.701000													6	28					0	0	3.59834e-05	0	0
OR52N2	390077	broad.mit.edu	37	11	5842271	5842271	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr11:5842271C>T	uc010qzp.1	+	1	706	c.706C>T	c.(706-708)CGT>TGT	p.R236C	TRIM5_uc001mbq.1_Intron	NM_001005174	NP_001005174	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N,	236	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGCAGATGCTCGTCACAAAGC	0.428000													6	64					0	0	3.59834e-05	0	0
OR5D13	390142	broad.mit.edu	37	11	55541597	55541597	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr11:55541597G>A	uc010ril.1	+	1	684	c.684G>A	c.(682-684)ATG>ATA	p.M228I		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	228	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				CTACCATTATGAAGATGCGAT	0.418000													7	39					0	0	8.12818e-05	0	0
PC	5091	broad.mit.edu	37	11	66618319	66618319	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr11:66618319G>A	uc001ojn.1	-	16	2348	c.2299C>T	c.(2299-2301)CCA>TCA	p.P767S	PC_uc001ojo.1_Missense_Mutation_p.P767S|PC_uc001ojp.1_Missense_Mutation_p.P767S|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	767	Carboxyltransferase.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	ATGTGCAGTGGGAGGTCGGGG	0.662000													5	14					0	0	3.59834e-05	0	0
PC	5091	broad.mit.edu	37	11	66618334	66618334	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr11:66618334G>A	uc001ojn.1	-	16	2333	c.2284C>T	c.(2284-2286)CGC>TGC	p.R762C	PC_uc001ojo.1_Missense_Mutation_p.R762C|PC_uc001ojp.1_Missense_Mutation_p.R762C|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	762	Carboxyltransferase.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	TCGGGGAAGCGGTCCCGGAGG	0.657000													5	13					0	0	3.59834e-05	0	0
DNAJB13	374407	broad.mit.edu	37	11	73681103	73681103	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr11:73681103C>T	uc001ouo.2	+	8	1646	c.895C>T	c.(895-897)CCC>TCC	p.P299S		NM_153614	NP_705842	P59910	DJB13_HUMAN	testis spermatogenesis apoptosis-related protein	299					apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding				0	Breast(11;7.42e-05)					CATCCAGTTCCCCACCCGCCT	0.597000													7	50					0	0	0.000157383	0	0
FAT3	120114	broad.mit.edu	37	11	92085392	92085393	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr11:92085392_92085393CC>AA	uc001pdj.3	+	1	131_132	c.114_115CC>AA	c.(112-117)CCCCTG>CCAATG	p.L39M		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	39	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GGACTGGACCCCTGGGCTTCCA	0.545000										TCGA Ovarian(4;0.039)			12	471					0	0	6.4e-05	0	0
EXPH5	23086	broad.mit.edu	37	11	108381787	108381787	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr11:108381787C>T	uc001pkk.2	-	6	4558	c.4447G>A	c.(4447-4449)GAA>AAA	p.E1483K	EXPH5_uc010rvy.1_Missense_Mutation_p.E1295K|EXPH5_uc010rvz.1_Missense_Mutation_p.E1327K|EXPH5_uc010rwa.1_Missense_Mutation_p.E1407K	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1483					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CCTCTGCCTTCCCTAGGCTGT	0.473000													5	28					0	0	0.000602214	0	0
BSX	390259	broad.mit.edu	37	11	122852195	122852195	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr11:122852195G>A	uc010rzs.1	-	1	185	c.185C>T	c.(184-186)CCC>CTC	p.P62L		NM_001098169	NP_001091639	Q3C1V8	BSH_HUMAN	brain specific homeobox	62											0		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		CAAGAGGGTGGGTGTGGGCAT	0.587000													3	4					0	0	6.4e-05	0	0
ROBO3	64221	broad.mit.edu	37	11	124745136	124745136	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr11:124745136C>T	uc001qbc.2	+	14	2395	c.2203C>T	c.(2203-2205)CCT>TCT	p.P735S	ROBO3_uc010saq.1_5'Flank|ROBO3_uc001qbd.2_5'Flank|ROBO3_uc010sar.1_5'Flank|ROBO3_uc001qbe.2_5'Flank|ROBO3_uc001qbf.1_5'Flank	NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	735	Fibronectin type-III 2.|Extracellular (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		AAGAGGACTCCCTCCAGGGAC	0.582000													5	57					0	0	0.000602214	0	0
VWF	7450	broad.mit.edu	37	12	6103338	6103338	+	Silent	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr12:6103338G>A	uc001qnn.1	-	37	6538	c.6288C>T	c.(6286-6288)TTC>TTT	p.F2096F	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2096	VWFD 4.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	CCCTCAGCATGAAGTCATTGG	0.502000													10	18					0	0	0.000442599	0	0
KRT6A	3853	broad.mit.edu	37	12	52881517	52881517	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr12:52881517C>T	uc001sam.2	-	9	1891	c.1682G>A	c.(1681-1683)AGC>AAC	p.S561N		NM_005554	NP_005545	P02538	K2C6A_HUMAN	keratin 6A	561	Tail.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			ovary(4)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.189)		GTGCTTATAGCTCTTCCTGCT	0.597000													10	36					0	0	0.000673444	0	0
TIMELESS	8914	broad.mit.edu	37	12	56822881	56822881	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr12:56822881G>A	uc001slf.2	-	11	1258	c.1090C>T	c.(1090-1092)CAC>TAC	p.H364Y	TIMELESS_uc001slg.2_Missense_Mutation_p.H363Y	NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	364					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						CGAAGCAGGTGATCCTGACAT	0.488000													5	14					0	0	0.000602214	0	0
GCN1L1	10985	broad.mit.edu	37	12	120585034	120585034	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr12:120585034C>T	uc001txo.2	-	38	4782	c.4769G>A	c.(4768-4770)AGG>AAG	p.R1590K		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	1590	HEAT 10.				regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTGGGTCTTCCTGGAGGGATC	0.557000													6	16					0	0	3.59834e-05	0	0
GCN1L1	10985	broad.mit.edu	37	12	120587453	120587453	+	Silent	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr12:120587453G>A	uc001txo.2	-	36	4516	c.4503C>T	c.(4501-4503)TCC>TCT	p.S1501S		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	1501	HEAT 8.				regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAGCCAGTAAGGAGGGGAGCA	0.572000													4	31					0	0	0.000602214	0	0
TUBA3C	7278	broad.mit.edu	37	13	19748240	19748240	+	Silent	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr13:19748240C>T	uc009zzj.2	-	5	1165	c.1116G>A	c.(1114-1116)CAG>CAA	p.Q372Q		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	372					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		ACACAGCCCGCTGCACCTTGG	0.602000													6	36					0	0	3.59834e-05	0	0
RNF17	56163	broad.mit.edu	37	13	25376549	25376549	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr13:25376549G>A	uc001upr.2	+	14	1830	c.1789G>A	c.(1789-1791)GAA>AAA	p.E597K	RNF17_uc010tdd.1_Missense_Mutation_p.E456K|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.E597K|RNF17_uc001ups.2_Missense_Mutation_p.E536K	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	597					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		AGCTAAAGTGGAATTTTTGAA	0.333000													6	60					0	0	3.59834e-05	0	0
RIPK3	11035	broad.mit.edu	37	14	24805428	24805428	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr14:24805428C>T	uc001wpb.2	-	10	1720	c.1510G>A	c.(1510-1512)GAA>AAA	p.E504K	ADCY4_uc001wov.2_5'Flank|ADCY4_uc001wow.2_5'Flank|ADCY4_uc010toh.1_5'Flank|ADCY4_uc001wox.2_5'Flank|ADCY4_uc001woy.2_5'Flank|ADCY4_uc001woz.3_5'Flank|RIPK3_uc001wpa.2_Missense_Mutation_p.E304K|RIPK3_uc010alq.2_RNA|RIPK3_uc010toi.1_Missense_Mutation_p.E283K	NM_006871	NP_006862	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	504					apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			central_nervous_system(2)|ovary(1)|lung(1)	4				GBM - Glioblastoma multiforme(265;0.0181)		CTCCAGGCTTCAGGATCTTTA	0.567000													5	45					0	0	0.000602214	0	0
PSMA6	5687	broad.mit.edu	37	14	35780020	35780021	+	Missense_Mutation	DNP	CC	TT	TT	rs78322008		TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr14:35780020_35780021CC>TT	uc001wtd.2	+	4	437_438	c.328_329CC>TT	c.(328-330)CCT>TTT	p.P110F	KIAA0391_uc001wta.2_RNA|PSMA6_uc010tpt.1_Missense_Mutation_p.P31F|PSMA6_uc010tpu.1_Missense_Mutation_p.P31F	NM_002791	NP_002782	P60900	PSA6_HUMAN	proteasome alpha 6 subunit	110					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nuclear matrix|polysome|proteasome core complex, alpha-subunit complex|sarcomere	NF-kappaB binding|purine ribonucleoside triphosphate binding|RNA binding|threonine-type endopeptidase activity				0	Breast(36;0.0519)|Hepatocellular(127;0.158)		Lung(238;3.81e-05)|LUAD - Lung adenocarcinoma(48;5.59e-05)|Epithelial(34;0.00342)|all cancers(34;0.00973)	GBM - Glioblastoma multiforme(112;0.0234)		CTATGAGATTCCTGTGGACATG	0.421000													5	27					0	0	6.4e-05	0	0
TMEM63C	57156	broad.mit.edu	37	14	77718139	77718139	+	Silent	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr14:77718139C>T	uc001xtf.2	+	22	2258	c.2046C>T	c.(2044-2046)CTC>CTT	p.L682L	TMEM63C_uc010asq.1_Silent_p.L682L	NM_020431	NP_065164	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	682						integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		CAGGTTCTCTCCACGCCATCA	0.572000													5	37					0	0	3.59834e-05	0	0
C15orf2	23742	broad.mit.edu	37	15	24922338	24922338	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr15:24922338C>T	uc001ywo.2	+	1	1798	c.1324C>T	c.(1324-1326)CCT>TCT	p.P442S		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	442	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CCTGCCTATCCCTCCACTTTC	0.527000													10	55					0	0	0.000442599	0	0
UNC13C	440279	broad.mit.edu	37	15	54685348	54685348	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr15:54685348G>A	uc002ack.2	+	16	4816	c.4816G>A	c.(4816-4818)GAT>AAT	p.D1606N	UNC13C_uc002acl.2_Missense_Mutation_p.D436N	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1606					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TATTGATGAGGATAAAACTGC	0.353000													4	21					0	0	0.000602214	0	0
THSD4	79875	broad.mit.edu	37	15	71447214	71447214	+	Silent	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr15:71447214C>T	uc002atb.1	+	2	121	c.42C>T	c.(40-42)TTC>TTT	p.F14F		NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	14						proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						TCCTGTGTTTCCTTCTGCTGC	0.542000													9	50					0	0	0.000673444	0	0
LOC645752	645752	broad.mit.edu	37	15	78211577	78211577	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr15:78211577C>T	uc010bky.2	-	11	954	c.190G>A	c.(190-192)GAG>AAG	p.E64K		NR_027024				SubName: Full=GOLGA6 protein; Flags: Fragment;												0						CCTTCCACCTCCTGCCTCAGG	0.552000													10	70					0	0	0.000673444	0	0
RASGRF1	5923	broad.mit.edu	37	15	79291148	79291148	+	Silent	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr15:79291148C>T	uc002beq.2	-	19	3189	c.2814G>A	c.(2812-2814)AGG>AGA	p.R938R	RASGRF1_uc002bep.2_Silent_p.R922R|RASGRF1_uc010blm.1_Silent_p.R847R|RASGRF1_uc002ber.3_Silent_p.R922R|RASGRF1_uc010unh.1_Silent_p.R333R|RASGRF1_uc002beo.2_Silent_p.R154R	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	940					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						TGTCTCCATTCCTCTGGTCTG	0.577000													5	28					0	0	0.000602214	0	0
ISG20	3669	broad.mit.edu	37	15	89182723	89182723	+	Silent	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr15:89182723C>T	uc002bmv.1	+	2	419	c.126C>T	c.(124-126)TTC>TTT	p.F42F	ISG20_uc002bmu.1_Intron|ISG20_uc002bmw.1_RNA|ISG20_uc010upn.1_RNA	NM_002201	NP_002192	Q96AZ6	ISG20_HUMAN	interferon stimulated exonuclease	42					cell proliferation|DNA catabolic process, exonucleolytic|response to virus|RNA catabolic process|type I interferon-mediated signaling pathway	PML body	3'-5'-exoribonuclease activity|exoribonuclease II activity|metal ion binding|RNA binding|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity				0	Lung NSC(78;0.0554)|all_lung(78;0.103)		BRCA - Breast invasive adenocarcinoma(143;0.12)			ACGACAAGTTCATCCGGCCTG	0.647000													6	28					0	0	3.59834e-05	0	0
UNC45A	55898	broad.mit.edu	37	15	91486257	91486258	+	Silent	DNP	CC	AA	AA	rs79580307	byFrequency	TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr15:91486257_91486258CC>AA	uc002bqg.2	+	8	1312_1313	c.972_973CC>AA	c.(970-975)CCCCGG>CCAAGG	p.324_325PR>PR	UNC45A_uc002bqd.2_Silent_p.309_310PR>PR	NM_018671	NP_061141	Q9H3U1	UN45A_HUMAN	smooth muscle cell associated protein-1 isoform	324_325					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			AAGCGGTGCCCCGGAAGTCTCT	0.530000													11	264					0	0	6.4e-05	0	0
MCTP2	55784	broad.mit.edu	37	15	94841644	94841644	+	Silent	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr15:94841644C>T	uc002btj.2	+	1	215	c.150C>T	c.(148-150)CTC>CTT	p.L50L	MCTP2_uc010urg.1_Silent_p.L50L|MCTP2_uc002bti.2_Silent_p.L50L|MCTP2_uc010boj.2_5'UTR|MCTP2_uc010bok.2_Silent_p.L50L|MCTP2_uc002btg.3_Silent_p.L50L|MCTP2_uc002bth.3_Silent_p.L50L	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	50					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			GTCTCAGCCTCTCTGTGCCTG	0.587000													5	46					0	0	0.000602214	0	0
PRSS21	10942	broad.mit.edu	37	16	2871436	2871436	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr16:2871436G>A	uc002crt.2	+	6	881	c.775G>A	c.(775-777)GGA>AGA	p.G259R	PRSS21_uc002crs.2_Missense_Mutation_p.G257R|PRSS21_uc002crr.2_Missense_Mutation_p.G245R	NM_006799	NP_006790	Q9Y6M0	TEST_HUMAN	testisin isoform 1	259	Peptidase S1.				proteolysis	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	serine-type endopeptidase activity			ovary(1)|skin(1)	2						CGTGAGCTGGGGAGTGGGCTG	0.597000													8	19					0	0	0.000157383	0	0
ACSM2A	123876	broad.mit.edu	37	16	20492171	20492171	+	Silent	SNP	G	A	A	rs149737523		TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr16:20492171G>A	uc010bwe.2	+	13	1676	c.1437G>A	c.(1435-1437)GAG>GAA	p.E479E	ACSM2A_uc010vax.1_Silent_p.E400E|ACSM2A_uc002dhf.3_Silent_p.E479E|ACSM2A_uc002dhg.3_Silent_p.E479E|ACSM2A_uc010vay.1_Silent_p.E400E|ACSM2A_uc002dhh.3_Silent_p.E109E	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	479					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding	p.E479E(1)		skin(2)|breast(1)	3						CGGAGGTAGAGAATGCACTGA	0.587000													6	33					0	0	0.000157383	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25258248	25258248	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr16:25258248A>T	uc002dod.3	-	5	1676	c.1269T>A	c.(1267-1269)GAT>GAA	p.D423E	ZKSCAN2_uc010vcl.1_Missense_Mutation_p.D219E|ZKSCAN2_uc002doe.2_Missense_Mutation_p.D423E	NM_001012981	NP_001012999	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	423					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|breast(1)	4				GBM - Glioblastoma multiforme(48;0.0378)		TCAACAAAGCATCCATGTCCT	0.488000													15	77					0	0	0.000219431	0	0
ITGAM	3684	broad.mit.edu	37	16	31284771	31284771	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr16:31284771G>A	uc002ebq.2	+	8	888	c.790G>A	c.(790-792)GAT>AAT	p.D264N	ITGAM_uc002ebr.2_Missense_Mutation_p.D264N|ITGAM_uc010cam.1_5'Flank	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	264	VWFA.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						AAAGTTTGGCGATCCCTTGGG	0.498000													6	36					0	0	3.59834e-05	0	0
CNGB1	1258	broad.mit.edu	37	16	58001187	58001187	+	Silent	SNP	A	G	G			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr16:58001187A>G	uc002emt.2	-	2	69	c.4T>C	c.(4-6)TTG>CTG	p.L2L	CNGB1_uc010cdh.2_Silent_p.L2L|CNGB1_uc002emu.2_Silent_p.L2L	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	2					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						ACCCAGCCCAACATCCTGATG	0.582000													3	22					0	0	0.00024832	0	0
PMFBP1	83449	broad.mit.edu	37	16	72174358	72174358	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr16:72174358C>T	uc002fcc.3	-	6	932	c.760G>A	c.(760-762)GAT>AAT	p.D254N	PMFBP1_uc002fcd.2_Missense_Mutation_p.D254N|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Missense_Mutation_p.D109N	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	254										ovary(2)	2		Ovarian(137;0.179)				TGAATGAGATCATCCTGTTGA	0.448000													15	156					0	0	0.000308642	0	0
TUBB3	10381	broad.mit.edu	37	16	90001933	90001933	+	Silent	SNP	C	G	G			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr16:90001933C>G	uc002fph.1	+	4	1139	c.1074C>G	c.(1072-1074)CCC>CCG	p.P358P	TUBB3_uc002fpf.2_Silent_p.P705P|TUBB3_uc010ciz.1_Silent_p.P286P|TUBB3_uc002fpg.1_Silent_p.P212P|TUBB3_uc002fpi.1_Silent_p.P286P|TUBB3_uc002fpj.1_Silent_p.P286P|TUBB3_uc010cjb.1_Silent_p.P212P|TUBB3_uc002fpk.1_Silent_p.P212P	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	358					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		ACATCCCGCCCCGCGGCCTCA	0.607000													3	121					0	0	0.00024832	0	0
GLP2R	9340	broad.mit.edu	37	17	9760794	9760794	+	Silent	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr17:9760794C>T	uc002gmd.1	+	6	666	c.666C>T	c.(664-666)ATC>ATT	p.I222I		NM_004246	NP_004237	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor precursor	222	Helical; Name=2; (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				lung(2)|ovary(1)	3					Glucagon recombinant(DB00040)	CTTCTTTCATCCTGAGAACCC	0.493000													7	36					0	0	8.12818e-05	0	0
TRIM16L	147166	broad.mit.edu	37	17	18638497	18638497	+	Silent	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr17:18638497G>A	uc002gug.1	+	10	1458	c.771G>A	c.(769-771)GGG>GGA	p.G257G	TRIM16L_uc010vyf.1_Silent_p.G311G|TRIM16L_uc002guh.1_Silent_p.G257G|TRIM16L_uc010cqg.1_Silent_p.G359G|TRIM16L_uc002gui.1_Silent_p.G257G|TRIM16L_uc010vyg.1_Silent_p.G257G|TRIM16L_uc010vyh.1_3'UTR	NM_001037330	NP_001032407	Q309B1	TR16L_HUMAN	tripartite motif-containing 16-like	257	B30.2/SPRY.					cytoplasm					0						AATGGAACGGGAAGGAGTTCA	0.557000													13	63					0	0	0.000219431	0	0
TMEM132E	124842	broad.mit.edu	37	17	32959919	32959919	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr17:32959919C>T	uc002hif.2	+	7	1737	c.1409C>T	c.(1408-1410)CCC>CTC	p.P470L		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	470	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		CCTATCCTCCCCGACCGGAGG	0.592000													10	47					0	0	0.000673444	0	0
GPR179	440435	broad.mit.edu	37	17	36486526	36486526	+	Silent	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr17:36486526G>A	uc002hpz.2	-	11	2947	c.2926C>T	c.(2926-2928)CTG>TTG	p.L976L		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	976	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				actggtgccagggcaggggct	0.458000													4	26					0	0	0.00024832	0	0
KRT28	162605	broad.mit.edu	37	17	38954573	38954573	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr17:38954573C>T	uc002hvh.1	-	3	670	c.604G>A	c.(604-606)GAG>AAG	p.E202K		NM_181535	NP_853513	Q7Z3Y7	K1C28_HUMAN	keratin 25D	202	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				AGCGTCAGCTCGTCCAGGACT	0.498000													12	59					0	0	0.000978159	0	0
KRT32	3882	broad.mit.edu	37	17	39623286	39623286	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr17:39623286C>T	uc002hwr.2	-	1	353	c.292G>A	c.(292-294)GAA>AAA	p.E98K		NM_002278	NP_002269	Q14532	K1H2_HUMAN	keratin 32	98	Coil 1A.|Rod.				epidermis development	intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000812)				TGCATGGTTTCCTTCTCATTG	0.607000													6	67					0	0	0.000157383	0	0
KRT15	3866	broad.mit.edu	37	17	39672200	39672200	+	Silent	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr17:39672200C>T	uc002hwy.2	-	5	1154	c.963G>A	c.(961-963)GAG>GAA	p.E321E	KRT15_uc002hwz.2_Silent_p.E223E|KRT15_uc002hxa.2_Silent_p.E156E|KRT15_uc002hxb.1_Silent_p.E156E	NM_002275	NP_002266	P19012	K1C15_HUMAN	keratin 15	321	Rod.|Coil 2.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000286)				GGTCTGTGATCTCCGTCTTGC	0.597000													12	101					0	0	0.000151284	0	0
HLF	3131	broad.mit.edu	37	17	53345447	53345447	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr17:53345447G>C	uc002iug.1	+	2	976	c.451G>C	c.(451-453)GGT>CGT	p.G151R	HLF_uc010dce.1_Missense_Mutation_p.G66R|HLF_uc002iuh.2_Missense_Mutation_p.G66R|HLF_uc010wni.1_Missense_Mutation_p.Q99H	NM_002126	NP_002117	Q16534	HLF_HUMAN	hepatic leukemia factor	151					multicellular organismal development|rhythmic process|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						CATCAGACCAGGTAAGTGCCC	0.562000			T	TCF3	ALL								5	29					0	0	3.59834e-05	0	0
HSF5	124535	broad.mit.edu	37	17	56565428	56565428	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr17:56565428C>T	uc002iwi.1	-	1	332	c.208G>A	c.(208-210)GAG>AAG	p.E70K		NM_001080439	NP_001073908	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	70	By similarity.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TTGAAGAGCTCGGGCTcggcc	0.498000													5	22					0	0	3.59834e-05	0	0
TLK2	11011	broad.mit.edu	37	17	60613535	60613535	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr17:60613535G>A	uc010ddp.2	+	7	636	c.368G>A	c.(367-369)CGA>CAA	p.R123Q	TLK2_uc002izx.3_5'UTR|TLK2_uc002izz.3_Missense_Mutation_p.R123Q|TLK2_uc002jaa.3_Missense_Mutation_p.R91Q|TLK2_uc010wpd.1_Missense_Mutation_p.R91Q	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	123					cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						TTCCAGCGACGAGTAGAACAG	0.438000													7	25					0	0	0.000274275	0	0
PTPN2	5771	broad.mit.edu	37	18	12794451	12794451	+	Silent	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr18:12794451C>T	uc002krp.2	-	9	1268	c.1074G>A	c.(1072-1074)AAG>AAA	p.K358K	PTPN2_uc002krl.2_Silent_p.K358K|PTPN2_uc002krn.2_Silent_p.K381K|PTPN2_uc002kro.2_Silent_p.K358K|PTPN2_uc002krm.2_Intron	NM_002828	NP_002819	P17706	PTN2_HUMAN	protein tyrosine phosphatase, non-receptor type	358					interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway	endoplasmic reticulum|nucleoplasm	protein binding			skin(2)	2		Lung NSC(161;8.94e-06)				CTGTGGTGGCCTTTCTGTCCT	0.423000													11	22					0	0	0.000978159	0	0
CXXC1	30827	broad.mit.edu	37	18	47808968	47808968	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr18:47808968G>A	uc002leq.3	-	15	2699	c.1966C>T	c.(1966-1968)CGC>TGC	p.R656C	MBD1_uc002leg.2_5'Flank|MBD1_uc010dow.1_5'Flank|MBD1_uc010xdi.1_5'Flank|MBD1_uc002leh.3_5'Flank|MBD1_uc002len.2_5'Flank|MBD1_uc002lei.3_5'Flank|MBD1_uc002lej.3_5'Flank|MBD1_uc002lek.3_5'Flank|MBD1_uc002lel.3_5'Flank|MBD1_uc002lem.3_5'Flank|MBD1_uc010xdj.1_5'Flank|MBD1_uc010xdk.1_5'Flank|MBD1_uc010dox.1_5'Flank|MBD1_uc002leo.2_5'Flank|CXXC1_uc002lep.3_Missense_Mutation_p.R513C|CXXC1_uc002ler.3_Missense_Mutation_p.R660C|CXXC1_uc010doy.2_3'UTR	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	656					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						GAGGCTCAGCGGTCGGCACTG	0.652000													20	53					0	0	0.000295444	0	0
RAB27B	5874	broad.mit.edu	37	18	52546620	52546620	+	Silent	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr18:52546620G>A	uc002lfr.2	+	3	285	c.174G>A	c.(172-174)CCG>CCA	p.P58P		NM_004163	NP_004154	O00194	RB27B_HUMAN	RAB27B, member RAS oncogene family	58					protein transport|small GTPase mediated signal transduction	Golgi apparatus|plasma membrane	GTP binding|GTPase activity				0				Colorectal(16;0.0273)|READ - Rectum adenocarcinoma(59;0.219)		CACAAGGACCGAATGGATCTT	0.403000													14	38					0	0	0.000308642	0	0
ZNF558	148156	broad.mit.edu	37	19	8922255	8922255	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr19:8922255C>T	uc002mkn.1	-	6	1141	c.911G>A	c.(910-912)AGC>AAC	p.S304N	ZNF558_uc010xkh.1_Missense_Mutation_p.S233N|ZNF558_uc010dwg.1_Missense_Mutation_p.S304N	NM_144693	NP_653294	Q96NG5	ZN558_HUMAN	zinc finger protein 558	304	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)	1						CAGATAGGAGCTCTTCCTGAA	0.443000													8	48					0	0	0.000274275	0	0
MUC16	94025	broad.mit.edu	37	19	9059369	9059369	+	Silent	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr19:9059369C>T	uc002mkp.2	-	3	28281	c.28077G>A	c.(28075-28077)AGG>AGA	p.R9359R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9361	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTGATTCTTTCCTTGTGAGGG	0.517000													5	68					0	0	0.000602214	0	0
NWD1	284434	broad.mit.edu	37	19	16910720	16910720	+	Silent	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr19:16910720G>A	uc002neu.3	+	17	3905	c.3483G>A	c.(3481-3483)GGG>GGA	p.G1161G	NWD1_uc002net.3_Silent_p.G1026G|NWD1_uc002nev.3_Silent_p.G955G			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	1161	WD 8.						ATP binding			skin(3)|ovary(2)|pancreas(2)	7						CAGAACAGGGGACCCTTCTGG	0.577000													9	33					0	0	0.000673444	0	0
NPHS1	4868	broad.mit.edu	37	19	36321786	36321786	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr19:36321786G>A	uc002oby.2	-	28	3554	c.3554C>T	c.(3553-3555)CCG>CTG	p.P1185L		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	1185	Binds to NPHS2.|Cytoplasmic (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGCTCCAGACGGGGGGTACGT	0.542000													7	63					0	0	8.12818e-05	0	0
ZNF568	374900	broad.mit.edu	37	19	37428087	37428087	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr19:37428087G>A	uc002ofc.2	+	6	816	c.301G>A	c.(301-303)GAG>AAG	p.E101K	ZNF568_uc010efg.2_Missense_Mutation_p.E87K|ZNF568_uc010xtn.1_Missense_Mutation_p.E25K|ZNF568_uc002ofd.2_Missense_Mutation_p.E25K|ZNF568_uc010efe.2_Missense_Mutation_p.E25K|ZNF568_uc010eff.1_Missense_Mutation_p.E87K	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	101	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATTCAAGTTGGAGCAAGAAGA	0.398000													5	37					0	0	3.59834e-05	0	0
ZNF226	7769	broad.mit.edu	37	19	44681046	44681046	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr19:44681046C>T	uc002oyp.2	+	6	1775	c.1631C>T	c.(1630-1632)TCG>TTG	p.S544L	ZNF226_uc002oyq.2_Missense_Mutation_p.S427L|ZNF226_uc002oyr.2_Missense_Mutation_p.S427L|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Missense_Mutation_p.S544L|ZNF226_uc002oyt.2_Missense_Mutation_p.S544L	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	544	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				AGTCAAAGTTCGTATCTTCAA	0.443000													12	87					0	0	0.000151284	0	0
ZFP112	7771	broad.mit.edu	37	19	44833712	44833712	+	Missense_Mutation	SNP	G	A	A	rs144019017		TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr19:44833712G>A	uc010ejj.2	-	5	729	c.616C>T	c.(616-618)CAT>TAT	p.H206Y	ZFP112_uc002ozc.3_Missense_Mutation_p.H200Y|ZFP112_uc010xwy.1_Missense_Mutation_p.H223Y|ZFP112_uc010xwz.1_Missense_Mutation_p.H205Y	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	206					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.H200Y(1)		ovary(3)|skin(2)	5						TTACAGAAATGATTTTTCATG	0.393000													7	66					0	0	8.12818e-05	0	0
LIG1	3978	broad.mit.edu	37	19	48619170	48619170	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr19:48619170C>G	uc002pia.1	-	27	2756	c.2636G>C	c.(2635-2637)CGT>CCT	p.R879P	LIG1_uc010xze.1_Missense_Mutation_p.R572P|LIG1_uc002phz.1_RNA|LIG1_uc002pib.1_RNA|LIG1_uc010xzf.1_Missense_Mutation_p.R811P|LIG1_uc010xzg.1_Missense_Mutation_p.R848P	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I	879					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	CTTGTCTTCACGGACTCGAAT	0.637000								NER					3	10					0	0	6.4e-05	0	0
LRPPRC	10128	broad.mit.edu	37	2	44190810	44190811	+	Nonsense_Mutation	DNP	CC	AA	AA			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr2:44190810_44190811CC>AA	uc002rtr.2	-	12	1462_1463	c.1404_1405GG>TT	c.(1402-1407)TTGGGA>TTTTGA	p.468_469LG>F*	LRPPRC_uc010yob.1_Nonsense_Mutation_p.368_369LG>F*	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	468_469	PPR 8.				mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GGATGTACTCCCAATTCTTGCA	0.366000													9	350					0	0	6.4e-05	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69049632	69049632	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr2:69049632C>T	uc002seu.2	+	10	1722	c.1358C>T	c.(1357-1359)GCT>GTT	p.A453V	ARHGAP25_uc010fdg.2_Missense_Mutation_p.A454V|ARHGAP25_uc010yql.1_Missense_Mutation_p.A414V|ARHGAP25_uc002sew.2_Missense_Mutation_p.A446V|ARHGAP25_uc002sex.2_Missense_Mutation_p.A447V|ARHGAP25_uc002sey.2_Missense_Mutation_p.A180V	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	453					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						TTGACATCAGCTTTTCAGGGT	0.478000													17	50					0	0	0.000566183	0	0
LONRF2	164832	broad.mit.edu	37	2	100925677	100925677	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr2:100925677A>T	uc002tal.3	-	2	1330	c.690T>A	c.(688-690)GAT>GAA	p.D230E	LONRF2_uc010yvs.1_RNA	NM_198461	NP_940863	Q1L5Z9	LONF2_HUMAN	LON peptidase N-terminal domain and ring finger	230	TPR 3.				proteolysis		ATP-dependent peptidase activity|zinc ion binding			large_intestine(1)|skin(1)	2						ATAATGAATTATCATCAGGAG	0.358000													10	38					0	0	0.000442599	0	0
IWS1	55677	broad.mit.edu	37	2	128262652	128262652	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr2:128262652G>A	uc002ton.2	-	3	1130	c.827C>T	c.(826-828)TCG>TTG	p.S276L	IWS1_uc010yzl.1_RNA|uc002too.1_5'Flank|IWS1_uc010fma.2_RNA	NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	276	Glu-rich.|2.|3 X approximate tandem repeats.				transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		CTCACTTTCCGAATCACTGAT	0.542000													38	108					0	0	0.000437636	0	0
TTN	7273	broad.mit.edu	37	2	179431326	179431326	+	Silent	SNP	G	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr2:179431326G>T	uc010zfg.1	-	275	72053	c.71829C>A	c.(71827-71829)CCC>CCA	p.P23943P	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.P17638P|TTN_uc010zfi.1_Silent_p.P17571P|TTN_uc010zfj.1_Silent_p.P17446P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24870							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATCATAGATGGGTTTACCCC	0.438000													7	157					0.000157383	0.00195511	0.000157383	1	0
TTN	7273	broad.mit.edu	37	2	179437377	179437377	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr2:179437377A>C	uc010zfg.1	-	275	66002	c.65778T>G	c.(65776-65778)AGT>AGG	p.S21926R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S15621R|TTN_uc010zfi.1_Missense_Mutation_p.S15554R|TTN_uc010zfj.1_Missense_Mutation_p.S15429R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22853							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATATTTGCCACTGTCAAATC	0.438000													16	55					0	0	0.000958276	0	0
PDE1A	5136	broad.mit.edu	37	2	183095762	183095762	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr2:183095762C>T	uc002uos.2	-	6	646	c.562G>A	c.(562-564)GAT>AAT	p.D188N	PDE1A_uc010zfp.1_Missense_Mutation_p.D84N|PDE1A_uc002uoq.1_Missense_Mutation_p.D188N|PDE1A_uc010zfq.1_Missense_Mutation_p.D188N|PDE1A_uc002uor.2_Missense_Mutation_p.D172N|PDE1A_uc002uou.2_Missense_Mutation_p.D154N	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	188					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			TTGATAAGATCATATCTGGTA	0.338000													17	56					0	0	0.000566183	0	0
SIRPG	55423	broad.mit.edu	37	20	1616064	1616065	+	Nonsense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr20:1616064_1616065CC>TT	uc002wfm.1	-	4	994_995	c.929_930GG>AA	c.(928-930)TGG>TAA	p.W310*	SIRPG_uc002wfn.1_Intron|SIRPG_uc002wfo.1_Intron|uc002wfp.1_Intron	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	310	Extracellular (Potential).|Ig-like C1-type 2.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						ACCAGCTTGTCCAGTTGTAGGT	0.545000													6	78					0	0	6.4e-05	0	0
VPS16	64601	broad.mit.edu	37	20	2843503	2843503	+	Silent	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr20:2843503C>T	uc002whe.2	+	13	1302	c.1254C>T	c.(1252-1254)TTC>TTT	p.F418F	VPS16_uc002whh.2_RNA|PTPRA_uc002whj.2_5'Flank|VPS16_uc002whf.2_Intron|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_Silent_p.F104F|VPS16_uc002whi.2_5'Flank	NM_022575	NP_072097	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 isoform 1	418					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4						CCGACAGCTTCGTGCACATGT	0.582000													23	93					0	0	0.00047179	0	0
PLCB4	5332	broad.mit.edu	37	20	9404488	9404488	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr20:9404488C>T	uc002wnf.2	+	26	2513	c.2377C>T	c.(2377-2379)CAA>TAA	p.Q793*	PLCB4_uc010gbw.1_Nonsense_Mutation_p.Q793*|PLCB4_uc010gbx.2_Nonsense_Mutation_p.Q805*|PLCB4_uc002wne.2_Nonsense_Mutation_p.Q793*|PLCB4_uc002wnh.2_Nonsense_Mutation_p.Q640*	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	793					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						TGATGGCCTCCAAGCCGGATA	0.443000													7	24					0	0	0.000157383	0	0
SLC24A3	57419	broad.mit.edu	37	20	19665948	19665948	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr20:19665948G>A	uc002wrl.2	+	12	1464	c.1267G>A	c.(1267-1269)GAG>AAG	p.E423K		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	423	Cytoplasmic (Potential).|Poly-Glu.					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1						gaatgatgaggaggaagagga	0.388000													8	38					0	0	0.000157383	0	0
SLC24A3	57419	broad.mit.edu	37	20	19673952	19673952	+	Silent	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr20:19673952C>T	uc002wrl.2	+	13	1571	c.1374C>T	c.(1372-1374)TTC>TTT	p.F458F		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	458	Cytoplasmic (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1						CGCTGAGTTTCGTCTTATACT	0.458000											OREG0025804	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	46					0	0	3.59834e-05	0	0
C20orf26	26074	broad.mit.edu	37	20	20071504	20071504	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr20:20071504G>A	uc002wru.2	+	7	659	c.583G>A	c.(583-585)GAT>AAT	p.D195N	C20orf26_uc010gcw.1_Missense_Mutation_p.D149N|C20orf26_uc010zse.1_Missense_Mutation_p.D195N|C20orf26_uc010zsf.1_Missense_Mutation_p.D195N	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	195										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		AGACCATGACGATCTCATGCC	0.333000													30	80					0	0	0.000409698	0	0
C20orf186	149954	broad.mit.edu	37	20	31680353	31680353	+	Silent	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr20:31680353C>T	uc010zue.1	+	9	1248	c.1233C>T	c.(1231-1233)CCC>CCT	p.P411P		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	411						cytoplasm|extracellular region	lipid binding				0						AGCTGCCTCCCATGGGTGACA	0.592000													12	44					0	0	0.000151284	0	0
KCNB1	3745	broad.mit.edu	37	20	48098561	48098561	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr20:48098561C>T	uc002xur.1	-	1	621	c.457G>A	c.(457-459)GAG>AAG	p.E153K	KCNB1_uc002xus.1_Missense_Mutation_p.E153K	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	153	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CGTAGGGTCTCGGCCTCACGC	0.577000													6	58					0	0	3.59834e-05	0	0
C21orf99	149992	broad.mit.edu	37	21	14424142	14424142	+	RNA	SNP	C	T	T	rs1054926	by1000genomes	TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr21:14424142C>T	uc002yiy.3	+	5		c.2957C>T			C21orf99_uc002yja.3_RNA					Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						GAACACCTGACGAGGCTGCAC	0.443000													4	14					0	0	0.000602214	0	0
KRTAP10-8	386681	broad.mit.edu	37	21	46032614	46032614	+	Silent	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr21:46032614C>T	uc002zfo.1	+	1	619	c.597C>T	c.(595-597)ACC>ACT	p.T199T	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198695	NP_941968	P60410	KR108_HUMAN	keratin associated protein 10-8	199	15.|19 X 5 AA repeats of C-C-X(3).					keratin filament				large_intestine(1)|breast(1)	2						CTTGCTGCACCACCTCCTGCT	0.438000													17	78					0	0	0.000566183	0	0
MOV10L1	54456	broad.mit.edu	37	22	50558939	50558939	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr22:50558939G>A	uc003bjj.2	+	10	1546	c.1463G>A	c.(1462-1464)AGA>AAA	p.R488K	MOV10L1_uc003bjk.3_Missense_Mutation_p.R488K|MOV10L1_uc011arp.1_Missense_Mutation_p.R468K|MOV10L1_uc011arq.1_Missense_Mutation_p.R249K|MOV10L1_uc010hao.1_Intron	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	488					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		AGGAACTCAAGACGACAACTT	0.338000													6	60					0	0	3.59834e-05	0	0
BSN	8927	broad.mit.edu	37	3	49679978	49679978	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr3:49679978C>T	uc003cxe.3	+	3	1025	c.911C>T	c.(910-912)CCT>CTT	p.P304L		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	304					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		AGGGTGTCTCCTCAGCCCCCT	0.701000													5	8					0	0	3.59834e-05	0	0
POC1A	25886	broad.mit.edu	37	3	52130714	52130714	+	Silent	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr3:52130714G>A	uc003dcu.2	-	10	1314	c.996C>T	c.(994-996)TTC>TTT	p.F332F	POC1A_uc003dcv.2_Silent_p.F294F|POC1A_uc003dcw.2_Intron	NM_015426	NP_056241	Q8NBT0	POC1A_HUMAN	WD repeat domain 51A isoform 1	332						centriole|microtubule basal body					0						GGGGGACAGGGAAGTCCACTT	0.542000													10	57					0	0	0.00010058	0	0
ITIH3	3699	broad.mit.edu	37	3	52836750	52836750	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr3:52836750G>A	uc003dfv.2	+	13	1673	c.1637G>A	c.(1636-1638)CGG>CAG	p.R546Q	ITIH3_uc011bek.1_Intron	NM_002217	NP_002208	Q06033	ITIH3_HUMAN	inter-alpha (globulin) inhibitor H3	546					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|liver(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		CTGCAGGAGCGGGACTACATC	0.607000													10	32					0	0	0.000978159	0	0
ROBO2	6092	broad.mit.edu	37	3	77629266	77629266	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr3:77629266A>T	uc003dpy.3	+	16	3140	c.2497A>T	c.(2497-2499)ATC>TTC	p.I833F	ROBO2_uc003dpz.2_Missense_Mutation_p.I837F|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.I837F	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	833	Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GCCAATAATAATCGGTGAGTA	0.413000													8	52					0	0	0.000274275	0	0
HSPBAP1	79663	broad.mit.edu	37	3	122474149	122474149	+	Silent	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr3:122474149G>A	uc003efu.1	-	5	822	c.699C>T	c.(697-699)TTC>TTT	p.F233F	HSPBAP1_uc003efv.1_3'UTR	NM_024610	NP_078886	Q96EW2	HBAP1_HUMAN	Hspb associated protein 1	233	JmjC.					cytoplasm				ovary(1)|lung(1)	2				GBM - Glioblastoma multiforme(114;0.0531)		GAGCTTTCCGGAACTGAGGAA	0.418000													8	36					0	0	0.000274275	0	0
DIRC2	84925	broad.mit.edu	37	3	122598138	122598139	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr3:122598138_122598139CG>AT	uc003efw.3	+	9	1489_1490	c.1350_1351CG>AT	c.(1348-1353)CCCGGG>CCATGG	p.G451W	DIRC2_uc010hrl.2_RNA|DIRC2_uc010hrm.2_Missense_Mutation_p.G289W|uc003efx.1_RNA	NM_032839	NP_116228	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	451	Helical; (Potential).				transport	integral to membrane					0				GBM - Glioblastoma multiforme(114;0.0614)		GGTGCCTTCCCGGGTCGTGTTT	0.455000													10	314					0	0	6.4e-05	0	0
IFT122	55764	broad.mit.edu	37	3	129237958	129237958	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr3:129237958A>G	uc003emm.2	+	28	3606	c.3400A>G	c.(3400-3402)ATT>GTT	p.I1134V	IFT122_uc003eml.2_Missense_Mutation_p.I1185V|IFT122_uc003emn.2_Missense_Mutation_p.I1075V|IFT122_uc003emo.2_Missense_Mutation_p.I1024V|IFT122_uc003emp.2_Missense_Mutation_p.I984V|IFT122_uc010htc.2_Missense_Mutation_p.I1127V|IFT122_uc011bky.1_Missense_Mutation_p.I925V|IFT122_uc003emq.2_Missense_Mutation_p.I974V|IFT122_uc003emr.2_Missense_Mutation_p.I887V|IFT122_uc011bla.1_Missense_Mutation_p.I908V|IFT122_uc010hte.2_Missense_Mutation_p.I460V|IFT122_uc003ems.2_Missense_Mutation_p.I516V	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	1134					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						AGGCTCCCAGATTCTGCGGCT	0.572000													8	60					0	0	0.000978159	0	0
DBR1	51163	broad.mit.edu	37	3	137892420	137892421	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr3:137892420_137892421CC>AA	uc003erv.2	-	2	381_382	c.245_246GG>TT	c.(244-246)GGG>GTT	p.G82V	DBR1_uc003eru.2_Missense_Mutation_p.G31V	NM_016216	NP_057300	Q9UK59	DBR1_HUMAN	debranching enzyme homolog 1	82						nucleus	metal ion binding|RNA lariat debranching enzyme activity				0						CATGGTTTCCCCCAATGAAGAG	0.416000													9	305					0	0	6.4e-05	0	0
HLTF	6596	broad.mit.edu	37	3	148759958	148759958	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr3:148759958G>A	uc003ewq.1	-	19	2410	c.2192C>T	c.(2191-2193)CCC>CTC	p.P731L	HLTF_uc003ewr.1_Missense_Mutation_p.P731L|HLTF_uc003ews.1_Missense_Mutation_p.P730L|HLTF_uc010hve.1_Missense_Mutation_p.P730L	NM_139048	NP_620636	Q14527	HLTF_HUMAN	helicase-like transcription factor	731					chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			CCTACCTGAGGGGCCATTGGA	0.363000													7	38					0	0	0.000274275	0	0
NFXL1	152518	broad.mit.edu	37	4	47907310	47907310	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr4:47907310G>A	uc010igh.2	-	4	637	c.460C>T	c.(460-462)CAA>TAA	p.Q154*	NFXL1_uc003gxp.2_Nonsense_Mutation_p.Q154*|NFXL1_uc003gxq.3_RNA|NFXL1_uc010igi.2_Nonsense_Mutation_p.Q154*	NM_152995	NP_694540	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like	154						integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						GCCCCTGCTTGAAAAGCTTCA	0.338000													7	72					0	0	0.000157383	0	0
PET112L	5188	broad.mit.edu	37	4	152593947	152593947	+	Silent	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr4:152593947G>A	uc003iml.2	-	12	1524	c.1512C>T	c.(1510-1512)CTC>CTT	p.L504L	PET112L_uc003imk.2_RNA	NM_004564	NP_004555	O75879	GATB_HUMAN	PET112-like precursor	504						mitochondrion	ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor|translation factor activity, nucleic acid binding				0	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)			L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CAGAGTGGCAGAGCTGCTCCA	0.587000													7	21					0	0	0.000157383	0	0
DCHS2	54798	broad.mit.edu	37	4	155156816	155156816	+	Silent	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr4:155156816G>A	uc003inw.2	-	25	7623	c.7623C>T	c.(7621-7623)ATC>ATT	p.I2541I		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2541	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CCACCAGGCTGATTGAAAAGC	0.383000													5	27					0	0	0.000602214	0	0
GK3P	2713	broad.mit.edu	37	4	166200515	166200515	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr4:166200515C>T	uc003ird.3	-	1	661	c.283G>A	c.(283-285)GAA>AAA	p.E95K	KLHL2_uc003irb.2_Intron|KLHL2_uc011cjm.1_Intron|KLHL2_uc003irc.2_Intron|KLHL2_uc010ira.2_Intron	NM_000167	NP_000158			glycerol kinase isoform b												0						ACGGTGGTTTCCCTCTGGTTG	0.423000													12	82					0	0	0.000978159	0	0
CPE	1363	broad.mit.edu	37	4	166416768	166416768	+	Nonsense_Mutation	SNP	C	G	G			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr4:166416768C>G	uc003irg.3	+	8	1548	c.1271C>G	c.(1270-1272)TCA>TGA	p.S424*		NM_001873	NP_001864	P16870	CBPE_HUMAN	carboxypeptidase E preproprotein	424					cardiac left ventricle morphogenesis|neuropeptide signaling pathway|protein modification process	extracellular region|nucleus|plasma membrane	metallocarboxypeptidase activity|protein binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0962)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.137)	Glucagon recombinant(DB00040)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTTACAGCCTCAGCTCCAGGC	0.393000													8	65					0	0	0.000274275	0	0
F11	2160	broad.mit.edu	37	4	187197534	187197534	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr4:187197534G>A	uc003iza.1	+	7	1078	c.745G>A	c.(745-747)GAA>AAA	p.E249K		NM_000128	NP_000119	P03951	FA11_HUMAN	coagulation factor XI precursor	249	Apple 3.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity				0		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	ATGGCCCAAAGAATCTCAAAG	0.378000													5	39					0	0	0.000602214	0	0
DNAH5	1767	broad.mit.edu	37	5	13841027	13841027	+	Silent	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr5:13841027G>A	uc003jfd.2	-	34	5739	c.5697C>T	c.(5695-5697)ATC>ATT	p.I1899I		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1899	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GGTCATCAAAGATATCCCTTT	0.383000									Kartagener_syndrome				5	25					0	0	0.000602214	0	0
CAPSL	133690	broad.mit.edu	37	5	35910623	35910623	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr5:35910623C>T	uc003jjt.1	-	3	255	c.160G>A	c.(160-162)GAT>AAT	p.D54N	CAPSL_uc003jju.1_Missense_Mutation_p.D54N	NM_001042625	NP_001036090	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	54	EF-hand 1.|1 (Potential).					cytoplasm	calcium ion binding			skin(1)	1	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			CGATTATTATCGTCATCCATA	0.313000													6	33					0	0	3.59834e-05	0	0
SLC1A3	6507	broad.mit.edu	37	5	36686225	36686225	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr5:36686225G>A	uc003jkj.3	+	10	1959	c.1483G>A	c.(1483-1485)GAG>AAG	p.E495K	SLC1A3_uc011cox.1_Missense_Mutation_p.E388K|SLC1A3_uc010iuy.2_Missense_Mutation_p.E450K	NM_004172	NP_004163	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity	495					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	TGGGATTGTGGAGCACTTGTC	0.517000													7	59					0	0	0.000442599	0	0
OSMR	9180	broad.mit.edu	37	5	38918941	38918941	+	Splice_Site	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr5:38918941G>A	uc003jln.1	+	11	1730	c.1363_splice	c.e11-1	p.P455_splice	OSMR_uc011cpj.1_Splice_Site	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor						cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					ATTTTTTTCAGCCATTATCAA	0.338000													3	28					0	0	6.4e-05	0	0
GPR98	84059	broad.mit.edu	37	5	89990022	89990022	+	Silent	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr5:89990022G>A	uc003kju.2	+	33	7545	c.7449G>A	c.(7447-7449)AGG>AGA	p.R2483R	GPR98_uc003kjt.2_Silent_p.R189R|GPR98_uc003kjv.2_Silent_p.R83R	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2483	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GGACCTACAGGAAAAACATGA	0.493000													4	33					0	0	0.00024832	0	0
FBN2	2201	broad.mit.edu	37	5	127863582	127863582	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr5:127863582C>T	uc003kuu.2	-	4	954	c.515G>A	c.(514-516)GGA>GAA	p.G172E	FBN2_uc003kuv.2_Missense_Mutation_p.G139E|FBN2_uc003kuw.3_Missense_Mutation_p.G172E|FBN2_uc003kux.1_Missense_Mutation_p.G172E	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	172	EGF-like 2.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		ACAATAAGTTCCAATATATCC	0.373000													7	34					0	0	0.000157383	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140711946	140711946	+	Silent	SNP	C	G	G			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr5:140711946C>G	uc003lji.1	+	1	1695	c.1695C>G	c.(1693-1695)CCC>CCG	p.P565P	PCDHGA1_uc011dan.1_Silent_p.P565P	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	565	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCTGTACCCCGCCCTCCCCA	0.662000													10	95					0	0	0.000673444	0	0
CCDC90A	63933	broad.mit.edu	37	6	13802496	13802496	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr6:13802496A>T	uc003nbd.2	-	3	746	c.618T>A	c.(616-618)GAT>GAA	p.D206E	CCDC90A_uc010jpf.2_RNA	NM_001031713	NP_001026883	Q96AQ8	CC90A_HUMAN	coiled-coil domain containing 90A precursor	206						integral to membrane|mitochondrion					0	Breast(50;0.0027)|Ovarian(93;0.0964)	all_hematologic(90;0.117)				TGGTGACCATATCTTTGTAGA	0.408000													8	42					0	0	0.000274275	0	0
CCHCR1	54535	broad.mit.edu	37	6	31124632	31124632	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr6:31124632G>A	uc003nsr.3	-	3	229	c.106C>T	c.(106-108)CCC>TCC	p.P36S	CCHCR1_uc011dne.1_Missense_Mutation_p.P36S|CCHCR1_uc003nsq.3_Intron|CCHCR1_uc003nsp.3_Missense_Mutation_p.P125S|CCHCR1_uc010jsk.1_Missense_Mutation_p.P36S|TCF19_uc003nss.2_5'Flank|TCF19_uc003nst.2_5'Flank	NM_019052	NP_061925	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1 isoform	36					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			skin(1)	1						TGGACCAGGGGAATGTCTGAG	0.562000													10	59					0	0	0.000978159	0	0
C6orf138	442213	broad.mit.edu	37	6	47847233	47847233	+	Silent	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr6:47847233G>A	uc011dwm.1	-	3	1381	c.1296C>T	c.(1294-1296)TTC>TTT	p.F432F	C6orf138_uc011dwn.1_Silent_p.F196F	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	449						integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						GTTCACGGAGGAAGTGCTGAA	0.453000													7	41					0	0	8.12818e-05	0	0
PKHD1	5314	broad.mit.edu	37	6	51774107	51774107	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr6:51774107G>A	uc003pah.1	-	40	6932	c.6656C>T	c.(6655-6657)TCA>TTA	p.S2219L	PKHD1_uc010jzn.1_Missense_Mutation_p.S244L|PKHD1_uc003pai.2_Missense_Mutation_p.S2219L	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	2219	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CAGAGTGAGTGAGCTCAGATG	0.512000													10	47					0	0	0.000978159	0	0
OLIG3	167826	broad.mit.edu	37	6	137814843	137814843	+	Silent	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr6:137814843G>A	uc003qhp.1	-	1	689	c.465C>T	c.(463-465)CAC>CAT	p.H155H		NM_175747	NP_786923	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		AGGCCGAGTGGTGGCCCCCAT	0.672000													5	21					0	0	0.000602214	0	0
TAGAP	117289	broad.mit.edu	37	6	159457477	159457477	+	Silent	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr6:159457477C>T	uc003qrz.2	-	10	1910	c.1578G>A	c.(1576-1578)GCG>GCA	p.A526A	TAGAP_uc011eft.1_Silent_p.A463A|TAGAP_uc003qsa.2_Silent_p.A348A	NM_054114	NP_473455	Q8N103	TAGAP_HUMAN	T-cell activation Rho GTPase-activating protein	526					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TCCCAGAGCCCGCGCTGAGGT	0.527000													9	51					0	0	0.000442599	0	0
HDAC9	9734	broad.mit.edu	37	7	18631231	18631231	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr7:18631231C>T	uc003suh.2	+	4	540	c.499C>T	c.(499-501)CAT>TAT	p.H167Y	HDAC9_uc003sue.2_Missense_Mutation_p.H167Y|HDAC9_uc011jyd.1_Missense_Mutation_p.H167Y|HDAC9_uc003sui.2_Missense_Mutation_p.H170Y|HDAC9_uc003suj.2_Missense_Mutation_p.H170Y|HDAC9_uc011jya.1_Missense_Mutation_p.H208Y|HDAC9_uc003sua.1_Missense_Mutation_p.H189Y|HDAC9_uc011jyb.1_Missense_Mutation_p.H167Y|HDAC9_uc003sud.1_Missense_Mutation_p.H167Y|HDAC9_uc011jyc.1_Missense_Mutation_p.H170Y|HDAC9_uc003suf.1_Missense_Mutation_p.H198Y|HDAC9_uc010kud.1_Missense_Mutation_p.H170Y|HDAC9_uc011jye.1_Missense_Mutation_p.H139Y|HDAC9_uc011jyf.1_Missense_Mutation_p.H136Y|HDAC9_uc010kue.1_5'UTR	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	167					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	TGGAAAAAATCATTCCGTGAG	0.383000													6	27					0	0	0.000157383	0	0
ABCB1	5243	broad.mit.edu	37	7	87196132	87196132	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr7:87196132C>T	uc003uiz.1	-	7	917	c.499G>A	c.(499-501)GAT>AAT	p.D167N	ABCB1_uc011khc.1_Intron	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	167	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TCCCCAACATCGTGCACATCA	0.383000													5	45					0	0	0.000602214	0	0
CALU	813	broad.mit.edu	37	7	128409143	128409143	+	Silent	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr7:128409143C>T	uc003vns.2	+	7	1022	c.870C>T	c.(868-870)ATC>ATT	p.I290I	CALU_uc003vnq.2_Silent_p.I290I|CALU_uc003vnr.2_Silent_p.I290I	NM_001130674	NP_001124146	O43852	CALU_HUMAN	calumenin isoform b precursor	290	EF-hand 6.				platelet activation|platelet degranulation	extracellular region|Golgi apparatus|melanosome|sarcoplasmic reticulum lumen	calcium ion binding|protein binding				0						AGGAGGAGATCGTTGACAAGT	0.423000													6	42					0	0	8.12818e-05	0	0
FLNC	2318	broad.mit.edu	37	7	128478742	128478742	+	Silent	SNP	T	C	C			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr7:128478742T>C	uc003vnz.3	+	8	1505	c.1296T>C	c.(1294-1296)GGT>GGC	p.G432G	FLNC_uc003voa.3_Silent_p.G432G	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	432	Filamin 2.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						AGGACAAGGGTGACAGCACGT	0.652000													18	83					0	0	0.00074312	0	0
FLNC	2318	broad.mit.edu	37	7	128489398	128489398	+	Silent	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr7:128489398C>T	uc003vnz.3	+	30	5174	c.4965C>T	c.(4963-4965)GGC>GGT	p.G1655G	FLNC_uc003voa.3_Silent_p.G1655G	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1655	Filamin 15.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CCTGCCTGGGCCCTCGAATCC	0.677000													6	30					0	0	3.59834e-05	0	0
TSGA14	95681	broad.mit.edu	37	7	130039943	130039944	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr7:130039943_130039944GG>TT	uc003vpz.2	-	10	956_957	c.909_910CC>AA	c.(907-912)ACCCCA>ACAACA	p.P304T	TSGA14_uc003vpy.2_Missense_Mutation_p.P66T|TSGA14_uc010lmf.2_Missense_Mutation_p.P101T|TSGA14_uc003vqa.2_Intron|TSGA14_uc011kpg.1_Intron	NM_018718	NP_061188	Q9BYV8	CEP41_HUMAN	testis specific, 14	304					G2/M transition of mitotic cell cycle	centrosome|cytosol					0	Melanoma(18;0.0435)					AAGTCTTCTGGGGTAAATCTCC	0.470000													11	359					0	0	6.4e-05	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				7	49					0	0	0.000157383	0	0
OR9A2	135924	broad.mit.edu	37	7	142723983	142723983	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr7:142723983C>T	uc003wcc.1	-	1	237	c.237G>A	c.(235-237)ATG>ATA	p.M79I		NM_001001658	NP_001001658	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A,	79	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.059)					CCCAAAGCATCATGGGGACAA	0.478000													6	77					0	0	3.59834e-05	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147964199	147964200	+	Missense_Mutation	DNP	CT	TA	TA			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr7:147964199_147964200CT>TA	uc003weu.1	+	21	3972_3973	c.3456_3457CT>TA	c.(3454-3459)CTCTTT>CTTATT	p.F1153I		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	1153	Laminin G-like 4.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CCAAGTCGCTCTTTCTGGGAAA	0.406000										HNSCC(39;0.1)			21	71					0	0	6.4e-05	0	0
PTPRN2	5799	broad.mit.edu	37	7	157691392	157691392	+	Silent	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr7:157691392C>T	uc003wno.2	-	12	1882	c.1761G>A	c.(1759-1761)CTG>CTA	p.L587L	PTPRN2_uc003wnp.2_Silent_p.L570L|PTPRN2_uc003wnq.2_Silent_p.L558L|PTPRN2_uc003wnr.2_Silent_p.L549L|PTPRN2_uc011kwa.1_Silent_p.L610L	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	587	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GAAGAATTTTCAGTCCAGAGG	0.522000													16	149					0	0	0.000566183	0	0
SGCZ	137868	broad.mit.edu	37	8	14022128	14022128	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr8:14022128C>G	uc003wwq.2	-	5	1168	c.508G>C	c.(508-510)GAT>CAT	p.D170H	SGCZ_uc010lss.2_Missense_Mutation_p.D123H	NM_139167	NP_631906	Q96LD1	SGCZ_HUMAN	sarcoglycan zeta	157	Extracellular (Potential).				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				ovary(2)|central_nervous_system(1)	3				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		GTAATCTCATCTTCATCTGCA	0.413000													5	44					0	0	0.000602214	0	0
ENTPD4	9583	broad.mit.edu	37	8	23243475	23243475	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr8:23243475G>A	uc011kzu.1	-	13	1954	c.1682C>T	c.(1681-1683)GCC>GTC	p.A561V	LOXL2_uc003xdh.1_Intron	NM_001128930	NP_001122402	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	Error:Variant_position_missing_in_Q9Y227_after_alignment					UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			ovary(1)|kidney(1)	2		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		gtgtttggtggccccatatgg	0.015000													5	55					0	0	3.59834e-05	0	0
GTF2E2	2961	broad.mit.edu	37	8	30464633	30464633	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr8:30464633G>T	uc003xig.2	-	6	837	c.584C>A	c.(583-585)CCC>CAC	p.P195H		NM_002095	NP_002086	P29084	T2EB_HUMAN	general transcription factor IIE, polypeptide 2,	195					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	transcription factor TFIIE complex	DNA binding|protein binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.113)|Kidney(114;0.135)		CTTCTTATCGGGACGATTTAC	0.303000													8	55					7.48243e-07	9.3508e-06	0.000442599	1	0
PCMTD1	115294	broad.mit.edu	37	8	52746112	52746112	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr8:52746112A>G	uc003xqx.3	-	4	889	c.548T>C	c.(547-549)GTT>GCT	p.V183A	PCMTD1_uc011ldm.1_Missense_Mutation_p.V53A|PCMTD1_uc003xqw.3_Missense_Mutation_p.V183A|PCMTD1_uc011ldn.1_5'UTR|PCMTD1_uc010lya.2_Missense_Mutation_p.V107A|PCMTD1_uc011ldo.1_Missense_Mutation_p.V183A	NM_052937	NP_443169	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate)	183						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0		Lung NSC(129;0.0795)|all_lung(136;0.144)				TATGCCTCCAACTTTTAGTAA	0.383000													7	52					0	0	0.000274275	0	0
PREX2	80243	broad.mit.edu	37	8	68995598	68995598	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr8:68995598G>A	uc003xxv.1	+	18	2029	c.2002G>A	c.(2002-2004)GTT>ATT	p.V668I	PREX2_uc003xxu.1_Missense_Mutation_p.V668I|PREX2_uc011lez.1_Missense_Mutation_p.V603I	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	668	PDZ 1.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						ACCTCTAAGAGTTCTTGTGAG	0.313000													10	43					0	0	0.000673444	0	0
EYA1	2138	broad.mit.edu	37	8	72129059	72129059	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr8:72129059G>A	uc003xys.3	-	13	1515	c.1228C>T	c.(1228-1230)CCT>TCT	p.P410S	EYA1_uc003xyr.3_Missense_Mutation_p.P375S|EYA1_uc003xyt.3_Missense_Mutation_p.P377S|EYA1_uc010lzf.2_Missense_Mutation_p.P337S|EYA1_uc003xyu.2_Missense_Mutation_p.P410S|EYA1_uc011lfe.1_Missense_Mutation_p.P404S|EYA1_uc003xyv.2_Missense_Mutation_p.P288S	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	410					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			GCTGCAGCAGGAAAGCCATCT	0.433000													18	49					0	0	0.00074312	0	0
TLE4	7091	broad.mit.edu	37	9	82267644	82267644	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr9:82267644T>C	uc004ald.2	+	7	1355	c.506T>C	c.(505-507)CTA>CCA	p.L169P	TLE4_uc004alc.2_Missense_Mutation_p.L176P|TLE4_uc010mpr.2_Missense_Mutation_p.L55P|TLE4_uc004ale.2_5'UTR|TLE4_uc011lsq.1_Missense_Mutation_p.L144P|TLE4_uc010mps.2_Missense_Mutation_p.L169P|TLE4_uc004alf.2_Missense_Mutation_p.L115P	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						TCCAGTGCTCTAGGAGGTCAG	0.542000													11	62					0	0	0.000151284	0	0
FLJ46321	389763	broad.mit.edu	37	9	84606551	84606551	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr9:84606551T>C	uc004amn.2	+	4	1213	c.1166T>C	c.(1165-1167)TTT>TCT	p.F389S		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	389						integral to membrane					0						TCTGAGGCCTTTTTAGGGGGG	0.473000													3	43					0	0	6.4e-05	0	0
BSPRY	54836	broad.mit.edu	37	9	116132413	116132413	+	Silent	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr9:116132413C>T	uc004bhg.3	+	6	1248	c.1200C>T	c.(1198-1200)ATC>ATT	p.I400I	BSPRY_uc010muw.2_3'UTR	NM_017688	NP_060158	Q5W0U4	BSPRY_HUMAN	B-box and SPRY domain containing	400	B30.2/SPRY.				calcium ion transport	cytoplasm|membrane	zinc ion binding			breast(1)	1						CCATTTCTATCGTCCGCTGAC	0.577000													8	29					0	0	0.000157383	0	0
NLGN3	54413	broad.mit.edu	37	X	70387190	70387190	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chrX:70387190G>A	uc004dzd.1	+	6	1443	c.1243G>A	c.(1243-1245)GAA>AAA	p.E415K	NLGN3_uc010nlb.1_Missense_Mutation_p.E375K|NLGN3_uc004dzb.2_Missense_Mutation_p.E395K|NLGN3_uc004dzc.2_Missense_Mutation_p.E278K|NLGN3_uc011mps.1_Missense_Mutation_p.E375K|NLGN3_uc004dze.2_Missense_Mutation_p.E213K	NM_018977	NP_061850	Q9NZ94	NLGN3_HUMAN	neuroligin 3	415	Extracellular (Potential).				neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			ovary(1)	1	Renal(35;0.156)					CAAGTTTGTGGAAGGGGTGGT	0.512000													11	36					0	0	0.000978159	0	0
XIST	7503	broad.mit.edu	37	X	73064974	73064974	+	RNA	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chrX:73064974C>T	uc004ebm.1	-	1		c.7615G>A				NR_001564				Homo sapiens cDNA: FLJ21545 fis, clone COL06195.												0						TGGTTGTGGTCACATACAATT	0.498000													13	76					0	0	0.000151284	0	0
KIAA2022	340533	broad.mit.edu	37	X	73960047	73960047	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chrX:73960047G>A	uc004eby.2	-	3	4962	c.4345C>T	c.(4345-4347)CGT>TGT	p.R1449C		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1449					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GATTTGTGACGATACAACTTT	0.453000													12	67					0	0	0.000151284	0	0
KIAA2022	340533	broad.mit.edu	37	X	73960458	73960458	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chrX:73960458C>T	uc004eby.2	-	3	4551	c.3934G>A	c.(3934-3936)GAA>AAA	p.E1312K		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1312					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TCCTGAAATTCCCGTTGGTCA	0.522000													9	86					0	0	0.000274275	0	0
FAM199X	139231	broad.mit.edu	37	X	103434359	103434359	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chrX:103434359C>T	uc004elw.2	+	6	1233	c.1067C>T	c.(1066-1068)GCC>GTC	p.A356V	FAM199X_uc004elx.2_Missense_Mutation_p.A130V	NM_207318	NP_997201	Q6PEV8	F199X_HUMAN	hypothetical protein LOC139231	356										ovary(1)	1						CAGAGGCAGGCCCGGAAGGAG	0.478000													4	69					0	0	0.000602214	0	0
TEX13A	56157	broad.mit.edu	37	X	104464008	104464008	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chrX:104464008C>T	uc004ema.2	-	5	980	c.868G>A	c.(868-870)GAA>AAA	p.E290K	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_Silent_p.Q290Q	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	290						intracellular	zinc ion binding			ovary(2)	2						GGAAGAGGTTCTGATGAGGCT	0.522000													6	43					0	0	3.59834e-05	0	0
GUCY2F	2986	broad.mit.edu	37	X	108708449	108708449	+	Silent	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chrX:108708449G>A	uc004eod.3	-	3	1230	c.954C>T	c.(952-954)TCC>TCT	p.S318S	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	318	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						TCTTTTCTTGGGACTCCACTG	0.473000													12	115					0	0	0.000151284	0	0
NKAP	79576	broad.mit.edu	37	X	119072753	119072753	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chrX:119072753C>T	uc004esh.2	-	2	574	c.407G>A	c.(406-408)AGA>AAA	p.R136K	NKAP_uc004esg.2_5'Flank	NM_024528	NP_078804	Q8N5F7	NKAP_HUMAN	NFKB activating protein	136					negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			ovary(2)	2						TTCTCCAATTCTCTCTCTCTC	0.313000													9	78					0	0	0.000274275	0	0
GRIA3	2892	broad.mit.edu	37	X	122538614	122538614	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chrX:122538614G>A	uc004etq.3	+	11	1642	c.1349G>A	c.(1348-1350)CGA>CAA	p.R450Q	GRIA3_uc004etr.3_Missense_Mutation_p.R450Q|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_Missense_Mutation_p.R434Q	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	450	Extracellular (Potential).		R -> Q (in MRX94).		glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	GGAAATGAACGATATGAAGGC	0.388000													8	32					0	0	0.000274275	0	0
GPC4	2239	broad.mit.edu	37	X	132458257	132458257	+	Silent	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chrX:132458257G>A	uc004exc.1	-	3	839	c.627C>T	c.(625-627)CTC>CTT	p.L209L	GPC4_uc011mvg.1_Silent_p.L139L	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	209					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					GAGTAACCTGGAGCTTCAATT	0.512000													9	74					0	0	0.000274275	0	0
HTATSF1	27336	broad.mit.edu	37	X	135584969	135584969	+	Silent	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chrX:135584969G>A	uc004ezw.2	+	6	1025	c.603G>A	c.(601-603)TTG>TTA	p.L201L	HTATSF1_uc004ezx.2_Silent_p.L201L	NM_001163280	NP_001156752	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	201	RRM 1.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					TAAAACTTTTGGATGAAGATG	0.328000													10	64					0	0	0.00010058	0	0
CXorf1	9142	broad.mit.edu	37	X	144909378	144909378	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chrX:144909378T>A	uc004fch.2	+	1	451	c.183T>A	c.(181-183)TTT>TTA	p.F61L		NM_004709	NP_004700	O96002	CX001_HUMAN	hypothetical protein LOC9142	61											0	Acute lymphoblastic leukemia(192;6.56e-05)					TTTTTATTTTTATCTTCCACA	0.353000													8	61					0	0	0.000673444	0	0
MTM1	4534	broad.mit.edu	37	X	149807437	149807437	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chrX:149807437G>A	uc004fef.3	+	7	542	c.466G>A	c.(466-468)GAA>AAA	p.E156K	MTM1_uc011mxx.1_RNA|MTM1_uc011mxy.1_Missense_Mutation_p.E119K|MTM1_uc011mxz.1_Missense_Mutation_p.E41K|MTM1_uc010nte.2_Missense_Mutation_p.E24K	NM_000252	NP_000243	Q13496	MTM1_HUMAN	myotubularin	156					endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ATTTTTAAATGAAGAAAAGTT	0.348000													10	82					0	0	0.000978159	0	0
GPR50	9248	broad.mit.edu	37	X	150348809	150348809	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chrX:150348809C>T	uc010ntg.1	+	2	889	c.754C>T	c.(754-756)CCT>TCT	p.P252S	uc004fes.1_5'Flank|GPR50_uc011myc.1_Intron	NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	252	Helical; Name=6; (Potential).				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GTGCTGGTGCCCTATCAACGT	0.512000													10	55					0	0	0.000978159	0	0
MMP12	4321	broad.mit.edu	37	11	102738795	102738796	+	Frame_Shift_Ins	INS	-	T	T	rs68192524		TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chr11:102738795_102738796insT	uc001phk.2	-	5	674_675	c.629_630insA	c.(628-630)ACCfs	p.T210fs		NM_002426	NP_002417	P39900	MMP12_HUMAN	matrix metalloproteinase 12 preproprotein	210					positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	AGGAACAAGTGGTGCCTAAGAA	0.416													3	6	---	---	---	---					
SLC6A14	11254	broad.mit.edu	37	X	115588915	115588915	+	Frame_Shift_Del	DEL	A	-	-			TCGA-EE-A2M8-06A-12D-A196-08	TCGA-EE-A2M8-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	8992de16-80d2-47d7-8d81-4ae0b9f2376e	e2077d51-fd1e-4a43-b100-9b58efdff71d	g.chrX:115588915delA	uc004eqi.2	+	13	1859	c.1755delA	c.(1753-1755)ATAfs	p.I585fs		NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	585	Cytoplasmic (Potential).				cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)	TCATAAAAATAATTCAGGCTA	0.333													23	151	---	---	---	---					
