Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MXRA8	54587	broad.mit.edu	37	1	1289861	1289861	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:1289861G>A	uc001aew.2	-	6	1009	c.978C>T	c.(976-978)GTC>GTT	p.V326V	MXRA8_uc001aex.3_Silent_p.V326V|MXRA8_uc001aey.3_Silent_p.V326V|MXRA8_uc010nyl.1_Silent_p.V326V|MXRA8_uc001aez.2_Silent_p.V225V|MXRA8_uc001afa.2_Silent_p.V317V	NM_032348	NP_115724	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8 precursor	326	Extracellular (Potential).					integral to membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		TGACATTGATGACGTTGTGGC	0.687000													18	34					0	0	0.001523	0	0
PRAMEF8	391002	broad.mit.edu	37	1	12979749	12979749	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:12979749G>T	uc001aup.2	+	4	1024	c.941G>T	c.(940-942)TGG>TTG	p.W314L		NM_001012276	NP_001012276	Q5VWM4	PRAM8_HUMAN	PRAME family member 8	314											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CATCTCTCTTGGTGCCCGAGC	0.562000													16	118					1.87028e-06	4.82336e-06	0.001882	1	0
SPEN	23013	broad.mit.edu	37	1	16257957	16257957	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:16257957C>T	uc001axk.1	+	11	5426	c.5222C>T	c.(5221-5223)TCG>TTG	p.S1741L	SPEN_uc010obp.1_Missense_Mutation_p.S1700L	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	1741					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CCCGGGGCCTCGTTTTCCCAG	0.562000													25	195					0	0	0.004656	0	0
MST1P9	11223	broad.mit.edu	37	1	17085485	17085485	+	Silent	SNP	G	A	A	rs3863809	by1000genomes	TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:17085485G>A	uc010ock.1	-	10	1206	c.1206C>T	c.(1204-1206)GCC>GCT	p.A402A	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_5'UTR	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						ACCATTTCCAGGCTCTGGTCC	0.622000													4	57					0	0	0.001984	0	0
ZNF683	257101	broad.mit.edu	37	1	26691377	26691377	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:26691377G>A	uc001bmg.1	-	4	778	c.660C>T	c.(658-660)CTC>CTT	p.L220L	ZNF683_uc001bmh.1_Silent_p.L220L|ZNF683_uc009vsj.1_Silent_p.L220L	NM_173574	NP_775845	Q8IZ20	ZN683_HUMAN	zinc finger protein 683	220					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		GGGGCAGCATGAGGAGGTGGG	0.617000													27	33					0	0	0.007291	0	0
DHDDS	79947	broad.mit.edu	37	1	26769251	26769252	+	Silent	DNP	CC	TT	TT			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:26769251_26769252CC>TT	uc001bml.2	+	4	331_332	c.210_211CC>TT	c.(208-213)ATCCTA>ATTTTA	p.70_71IL>IL	DHDDS_uc001bmk.2_Silent_p.70_71IL>IL|DHDDS_uc001bmm.2_5'UTR|DHDDS_uc001bmn.2_Silent_p.70_71IL>IL|DHDDS_uc010ofd.1_Silent_p.70_71IL>IL	NM_205861	NP_995583	Q86SQ9	DHDDS_HUMAN	dehydrodolichyl diphosphate synthase isoform b	70_71							protein binding|transferase activity, transferring alkyl or aryl (other than methyl) groups			breast(3)	3		all_cancers(24;2.04e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.0161)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.166)|LUSC - Lung squamous cell carcinoma(448;0.239)		ACCTGGGCATCCTAGAGGTGAC	0.515000													47	57					0	0	0.004672	0	0
PUM1	9698	broad.mit.edu	37	1	31501645	31501645	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:31501645C>T	uc001bsi.1	-	3	543	c.430G>A	c.(430-432)GAG>AAG	p.E144K	PUM1_uc001bsh.1_Missense_Mutation_p.E144K|PUM1_uc001bsj.1_Missense_Mutation_p.E144K|PUM1_uc010oga.1_Missense_Mutation_p.E144K|PUM1_uc001bsk.1_Missense_Mutation_p.E180K|PUM1_uc010ogb.1_Missense_Mutation_p.E180K	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2	144					cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		TCACTTACCTCTCCCATCGCT	0.408000													27	70					0	0	0.002445	0	0
CDCA8	55143	broad.mit.edu	37	1	38168923	38168923	+	Splice_Site	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:38168923G>A	uc001cbr.2	+	8	596	c.489_splice	c.e8-1	p.R163_splice	CDCA8_uc001cbs.2_Splice_Site_p.R163_splice|CDCA8_uc010oih.1_Splice_Site_p.R96_splice	NM_018101	NP_060571	Q53HL2	BOREA_HUMAN	cell division cycle associated 8						cell division|chromosome organization|mitotic metaphase|mitotic prometaphase	chromosome passenger complex|chromosome, centromeric region|cytosol|nucleolus|spindle	protein binding			central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CTTACCTGTAGGTCAAGCCGT	0.483000													62	68					0	0	0.003610	0	0
IPP	3652	broad.mit.edu	37	1	46180064	46180064	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:46180064A>G	uc001cou.2	-	8	1651	c.1384T>C	c.(1384-1386)TCT>CCT	p.S462P	IPP_uc001cos.3_Missense_Mutation_p.S462P	NM_005897	NP_005888	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	462	Kelch 4.					actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					CAACGCTTAGAAAGTGGATCA	0.423000													9	25					0	0	0.006214	0	0
CYP4A22	284541	broad.mit.edu	37	1	47610246	47610246	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:47610246G>A	uc001cqv.1	+	8	973	c.922G>A	c.(922-924)GAC>AAC	p.D308N	CYP4A22_uc009vyo.2_Missense_Mutation_p.D308N|CYP4A22_uc009vyp.2_Intron	NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	308						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						CATCTTGTCAGACAAGGACCT	0.557000													35	72					0	0	0.002222	0	0
STIL	6491	broad.mit.edu	37	1	47717418	47717418	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:47717418G>A	uc001crc.1	-	17	3409	c.3254C>T	c.(3253-3255)TCG>TTG	p.S1085L	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Missense_Mutation_p.S1039L|STIL_uc010omo.1_Missense_Mutation_p.S1068L|STIL_uc001crd.1_Missense_Mutation_p.S1086L|STIL_uc001cre.1_Missense_Mutation_p.S1085L	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	1085					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				ATTTTGGTTCGATCGAGTGAC	0.403000													44	84					0	0	0.003610	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52924079	52924079	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:52924079A>G	uc001ctx.2	-	20	3598	c.3364T>C	c.(3364-3366)TAT>CAT	p.Y1122H	ZCCHC11_uc001cty.2_Missense_Mutation_p.Y1122H|ZCCHC11_uc001ctz.2_Missense_Mutation_p.Y1122H|ZCCHC11_uc009vze.1_Missense_Mutation_p.Y1122H|ZCCHC11_uc009vzf.1_Intron|ZCCHC11_uc001cua.1_Missense_Mutation_p.Y39H	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	1122					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						ATATATGCATATGAAGATAAA	0.388000													25	42					0	0	0.005443	0	0
GLIS1	148979	broad.mit.edu	37	1	53995556	53995556	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:53995556C>T	uc001cvr.1	-	4	1432	c.865G>A	c.(865-867)GAG>AAG	p.E289K		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	289					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						TACGGCTTCTCGCCCGTGTGG	0.637000													6	25					0	0	0.001984	0	0
LRRC7	57554	broad.mit.edu	37	1	70226011	70226011	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:70226011T>A	uc001dep.2	+	1	154	c.124T>A	c.(124-126)TTT>ATT	p.F42I	LRRC7_uc001deo.1_Missense_Mutation_p.F80I|LRRC7_uc009wbg.2_5'UTR	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	42	LRR 1.					centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						AAAGGAGGTCTTTAACTTCGA	0.418000													6	23					0	0	0.003080	0	0
CLCA4	22802	broad.mit.edu	37	1	87045258	87045258	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:87045258G>A	uc009wcs.2	+	13	2388	c.2344G>A	c.(2344-2346)GAT>AAT	p.D782N	CLCA4_uc009wct.2_Missense_Mutation_p.D545N|CLCA4_uc009wcu.2_Missense_Mutation_p.D602N	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	782						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		AGATAATTTTGATGTTGGAAA	0.428000													7	35					0	0	0.003080	0	0
PALMD	54873	broad.mit.edu	37	1	100155218	100155218	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:100155218C>T	uc001dsg.2	+	7	1845	c.1402C>T	c.(1402-1404)CCC>TCC	p.P468S	PALMD_uc001dsf.2_Missense_Mutation_p.P468S	NM_017734	NP_060204	Q9NP74	PALMD_HUMAN	palmdelphin	468					regulation of cell shape	cytoplasm|membrane				ovary(2)|pancreas(1)	3		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		CCCCATAGCTCCCCATAGTCA	0.478000													6	7					0	0	0.001984	0	0
HIAT1	64645	broad.mit.edu	37	1	100546081	100546081	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:100546081C>T	uc001dst.2	+	11	1132	c.1132C>T	c.(1132-1134)CGA>TGA	p.R378*		NM_033055	NP_149044	Q96MC6	HIAT1_HUMAN	hippocampus abundant transcript 1	378	Extracellular (Potential).				transmembrane transport	integral to membrane|plasma membrane	transporter activity				0		all_epithelial(167;2.96e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0832)|all cancers(265;0.136)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)		AACAGGAATTCGAGGATTATG	0.388000													31	60					0	0	0.001786	0	0
VCAM1	7412	broad.mit.edu	37	1	101200183	101200183	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:101200183G>A	uc001dti.2	+	8	2038	c.1918G>A	c.(1918-1920)GAG>AAG	p.E640K	VCAM1_uc001dtj.2_Missense_Mutation_p.E548K|VCAM1_uc010ouj.1_Missense_Mutation_p.E578K	NM_001078	NP_001069	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1 isoform a	640	Ig-like C2-type 7.|Extracellular (Potential).				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(1)	1		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	GAAAAAAGCGGAGACAGGAGA	0.413000													8	14					0	0	0.004482	0	0
DRAM2	128338	broad.mit.edu	37	1	111660801	111660801	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:111660801A>G	uc001ead.3	-	9	1039	c.782T>C	c.(781-783)CTA>CCA	p.L261P	DRAM2_uc001eae.3_Missense_Mutation_p.L261P|DRAM2_uc009wfy.2_RNA|DRAM2_uc001eaf.3_Missense_Mutation_p.L131P	NM_178454	NP_848549	Q6UX65	DRAM2_HUMAN	transmembrane protein 77	261					apoptosis|induction of apoptosis	Golgi apparatus|integral to membrane|lysosomal membrane					0						TCTGGAAAGTAGCCGTGTTCG	0.378000													20	39					0	0	0.001882	0	0
TSHB	7252	broad.mit.edu	37	1	115576094	115576094	+	Silent	SNP	T	C	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:115576094T>C	uc001efs.1	+	2	179	c.111T>C	c.(109-111)GCT>GCC	p.A37A		NM_000549	NP_000540	P01222	TSHB_HUMAN	thyroid stimulating hormone, beta precursor	37					anatomical structure morphogenesis|cell-cell signaling|cellular nitrogen compound metabolic process|G-protein coupled receptor protein signaling pathway|hormone biosynthetic process|peptide hormone processing	extracellular region	hormone activity				0	Lung SC(450;0.211)	all_cancers(81;3.22e-07)|all_epithelial(167;1.4e-06)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)		GAGAGTGTGCTTATTGCCTAA	0.413000													30	32					0	0	0.002445	0	0
CD2	914	broad.mit.edu	37	1	117303207	117303207	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:117303207G>A	uc001egu.3	+	3	595	c.566G>A	c.(565-567)GGG>GAG	p.G189E	CD2_uc010owz.1_Missense_Mutation_p.G189E|CD2_uc010oxa.1_Intron	NM_001767	NP_001758	P06729	CD2_HUMAN	CD2 molecule precursor	189	Extracellular (Potential).|Ig-like C2-type.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			breast(1)	1	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	TGCACAGCAGGGAACAAAGTC	0.512000													11	27					0	0	0.001368	0	0
CA14	23632	broad.mit.edu	37	1	150235484	150235484	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:150235484C>T	uc001etx.2	+	7	915	c.606C>T	c.(604-606)CTC>CTT	p.L202L		NM_012113	NP_036245	Q9ULX7	CAH14_HUMAN	carbonic anhydrase XIV precursor	202	Extracellular (Potential).					integral to membrane	carbonate dehydratase activity|metal ion binding			ovary(1)	1	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAGAGCTGCTCCCCAAACAGC	0.522000													22	36					0	0	0.002299	0	0
C1orf56	54964	broad.mit.edu	37	1	151020995	151020995	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:151020995G>A	uc001ewn.2	+	1	737	c.672G>A	c.(670-672)GGG>GGA	p.G224G		NM_017860	NP_060330	Q9BUN1	CA056_HUMAN	hypothetical protein LOC54964 precursor	224						extracellular region					0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GCCGGTCTGGGAAGCTGCACG	0.657000											OREG0013793	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	53					0	0	0.001882	0	0
LELP1	149018	broad.mit.edu	37	1	153177316	153177316	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:153177316G>A	uc001fbl.2	+	2	243	c.133G>A	c.(133-135)GAA>AAA	p.E45K		NM_001010857	NP_001010857	Q5T871	LELP1_HUMAN	late cornified envelope-like proline-rich 1	45	Cys/Pro-rich.									ovary(1)	1	all_lung(78;3.51e-31)|Lung NSC(65;1.34e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACGCTGTTTCGAAAAGTGCCC	0.572000													19	48					0	0	0.002299	0	0
S100A13	6284	broad.mit.edu	37	1	153591502	153591502	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:153591502G>A	uc001fcf.3	-	3	325	c.166C>T	c.(166-168)CTT>TTT	p.L56F	S100A14_uc001fce.2_5'Flank|S100A13_uc001fcg.2_Missense_Mutation_p.L56F|S100A13_uc009woh.2_Missense_Mutation_p.L56F|S100A13_uc001fch.2_Missense_Mutation_p.L56F|S100A13_uc001fci.2_Missense_Mutation_p.L56F|S100A13_uc001fcj.2_Missense_Mutation_p.L56F	NM_001024213	NP_001019384	Q99584	S10AD_HUMAN	S100 calcium binding protein A13	56					interleukin-1 alpha secretion|mast cell degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|extracellular space|nucleus|perinuclear region of cytoplasm	calcium ion binding|copper ion binding|fibroblast growth factor 1 binding|lipid binding|protein homodimerization activity|RAGE receptor binding|zinc ion binding				0	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)		Amlexanox(DB01025)	TTCTCATCAAGAGAGCCCACA	0.483000													39	79					0	0	0.008740	0	0
FCRL5	83416	broad.mit.edu	37	1	157512838	157512838	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:157512838C>T	uc001fqu.2	-	6	1092	c.934G>A	c.(934-936)GAA>AAA	p.E312K	FCRL5_uc009wsm.2_Missense_Mutation_p.E312K|FCRL5_uc010phv.1_Missense_Mutation_p.E312K|FCRL5_uc010phw.1_Missense_Mutation_p.E227K|FCRL5_uc001fqv.1_Missense_Mutation_p.E312K|FCRL5_uc010phx.1_Missense_Mutation_p.E63K	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	312	Extracellular (Potential).|Ig-like C2-type 3.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				AGAGAATCTTCCTGGGTTTCA	0.512000													18	22					0	0	0.007413	0	0
OR6N1	128372	broad.mit.edu	37	1	158735715	158735715	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:158735715C>T	uc010piq.1	-	1	758	c.758G>A	c.(757-759)GGG>GAG	p.G253E		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	253	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					AAGGATGCTCCCATAGAAGAT	0.537000													22	79					0	0	0.003330	0	0
OLFML2B	25903	broad.mit.edu	37	1	161989927	161989927	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:161989927C>T	uc001gbu.2	-	2	644	c.220G>A	c.(220-222)GAC>AAC	p.D74N	OLFML2B_uc010pkq.1_Missense_Mutation_p.D74N	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	74										skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			CACTGACAGTCCGAGCCCTCA	0.567000													15	40					0	0	0.003163	0	0
FAM5C	339479	broad.mit.edu	37	1	190068027	190068027	+	Nonsense_Mutation	SNP	G	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:190068027G>T	uc001gse.1	-	8	1654	c.1422C>A	c.(1420-1422)TGC>TGA	p.C474*	FAM5C_uc010pot.1_Nonsense_Mutation_p.C372*	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	474						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					CTTCAGGCTTGCAGAGCCCCT	0.572000													24	150					8.24728e-16	2.14956e-15	0.004656	1	0
CRB1	23418	broad.mit.edu	37	1	197407692	197407692	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:197407692C>T	uc001gtz.2	+	10	3900	c.3765C>T	c.(3763-3765)CCC>CCT	p.P1255P	CRB1_uc010poz.1_Silent_p.P1231P|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Silent_p.P1143P|CRB1_uc010ppb.1_Silent_p.P719P|CRB1_uc010ppd.1_Silent_p.P736P|CRB1_uc001gub.1_Silent_p.P904P	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	1255	Extracellular (Potential).|EGF-like 18.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						GCAGATTACCCTCAACAGTCT	0.408000													14	57					0	0	0.003163	0	0
KCTD3	51133	broad.mit.edu	37	1	215792594	215792594	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:215792594C>T	uc001hks.2	+	17	2141	c.1847C>T	c.(1846-1848)TCC>TTC	p.S616F	KCTD3_uc001hkt.2_Missense_Mutation_p.S614F|KCTD3_uc010pub.1_Missense_Mutation_p.S514F|KCTD3_uc009xdn.2_Missense_Mutation_p.S340F	NM_016121	NP_057205	Q9Y597	KCTD3_HUMAN	potassium channel tetramerisation domain	616						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(3)	3				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		CCAGCAACTTCCGTAGTTCAG	0.393000													23	67					0	0	0.003330	0	0
WNT9A	7483	broad.mit.edu	37	1	228113089	228113089	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:228113089G>A	uc001hri.2	-	2	315	c.227C>T	c.(226-228)CCG>CTG	p.P76L		NM_003395	NP_003386	O14904	WNT9A_HUMAN	wingless-type MMTV integration site family,	76					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|cornea development in camera-type eye|embryonic arm morphogenesis|embryonic skeletal joint morphogenesis|endoderm development|iris morphogenesis|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|neuron differentiation|positive regulation of smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding|signal transducer activity			central_nervous_system(1)|pancreas(1)	2		Prostate(94;0.0405)				TGCCACGCCCGGGTCCCGGCG	0.701000													7	4					0	0	0.001984	0	0
B3GALNT2	148789	broad.mit.edu	37	1	235622058	235622058	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:235622058G>A	uc001hxc.2	-	8	1107	c.878C>T	c.(877-879)CCT>CTT	p.P293L		NM_152490	NP_689703	Q8NCR0	B3GL2_HUMAN	beta-1,3-N-acetylgalactosaminyltransferase 2	293	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			breast(1)	1	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.0539)|Prostate(94;0.0353)	OV - Ovarian serous cystadenocarcinoma(106;0.000117)			AAGTCTTTGAGGGCGAGAATG	0.383000													16	21					0	0	0.004007	0	0
OR14A16	284532	broad.mit.edu	37	1	247978878	247978878	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:247978878G>A	uc001idm.1	-	1	154	c.154C>T	c.(154-156)CAT>TAT	p.H52Y		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	52	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTGTGGAGATGATGGTCCAAA	0.393000													16	29					0	0	0.004990	0	0
OR2T33	391195	broad.mit.edu	37	1	248436229	248436229	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:248436229C>T	uc010pzi.1	-	1	888	c.888G>A	c.(886-888)AAG>AAA	p.K296K		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TCAGGGCTCCCTTCACCTCAC	0.458000													38	63					0	0	0.002222	0	0
NEBL	10529	broad.mit.edu	37	10	21076194	21076194	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr10:21076194G>A	uc001iqi.2	-	27	3202	c.2805C>T	c.(2803-2805)GGC>GGT	p.G935G	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Silent_p.G191G	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	935	Linker.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						TGTAGCCATAGCCTTGGGAAT	0.458000													10	18					0	0	0.000978	0	0
KIAA1462	57608	broad.mit.edu	37	10	30315364	30315364	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr10:30315364T>C	uc001iux.2	-	2	3772	c.3713A>G	c.(3712-3714)AAA>AGA	p.K1238R	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.K1100R|KIAA1462_uc009xle.1_Missense_Mutation_p.K1238R	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	1238										ovary(4)	4						TTCAATCACTTTGGAAGGGCT	0.483000													23	30					0	0	0.001882	0	0
ZEB1	6935	broad.mit.edu	37	10	31810698	31810698	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr10:31810698C>T	uc001ivs.3	+	7	2498	c.2435C>T	c.(2434-2436)CCC>CTC	p.P812L	ZEB1_uc001ivr.3_Missense_Mutation_p.P594L|ZEB1_uc010qee.1_Missense_Mutation_p.P594L|ZEB1_uc010qef.1_Missense_Mutation_p.P594L|ZEB1_uc009xlj.1_Missense_Mutation_p.P738L|ZEB1_uc010qeg.1_Missense_Mutation_p.P671L|ZEB1_uc009xlk.1_Missense_Mutation_p.P594L|ZEB1_uc001ivt.3_Missense_Mutation_p.P594L|ZEB1_uc001ivu.3_Missense_Mutation_p.P813L|ZEB1_uc001ivv.3_Missense_Mutation_p.P792L|ZEB1_uc010qeh.1_Missense_Mutation_p.P745L|ZEB1_uc009xlo.1_Missense_Mutation_p.P795L|ZEB1_uc009xlp.2_Missense_Mutation_p.P796L	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	812					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				GCCCAGTTACCCACAATCGTG	0.473000													14	31					0	0	0.003163	0	0
RBP3	5949	broad.mit.edu	37	10	48390817	48390817	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr10:48390817G>A	uc001jez.2	-	1	175	c.61C>T	c.(61-63)CAC>TAC	p.H21Y		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	21	4 X approximate tandem repeats.|1.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	TGGAACAGGTGTGTGGGGCCA	0.607000													14	21					0	0	0.002450	0	0
Unknown	0	broad.mit.edu	37	10	48968566	48968566	+	RNA	SNP	A	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr10:48968566A>G	uc001jgc.1	+	3		c.1234A>G								full-length cDNA clone CS0DI009YC01 of Placenta Cot 25-normalized of Homo sapiens (human).																		ACAGGATAACAAACTGGAAAA	0.284000													3	17					0	0	0.004672	0	0
SGMS1	259230	broad.mit.edu	37	10	52103615	52103615	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr10:52103615A>T	uc001jje.2	-	7	1214	c.260T>A	c.(259-261)ATT>AAT	p.I87N	SGMS1_uc010qhk.1_Intron|SGMS1_uc009xot.1_Intron|SGMS1_uc009xou.1_Missense_Mutation_p.I87N|SGMS1_uc010qhl.1_RNA	NM_147156	NP_671512	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	93					apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			ovary(1)|kidney(1)	2						GTCTACGCCAATGTTGAGGTG	0.512000													21	26					0	0	0.002780	0	0
TFAM	7019	broad.mit.edu	37	10	60154712	60154712	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr10:60154712G>A	uc001jkf.2	+	7	751	c.619G>A	c.(619-621)GAC>AAC	p.D207N	TFAM_uc001jkg.2_RNA|TFAM_uc001jkh.2_Missense_Mutation_p.D175N	NM_003201	NP_003192	Q00059	TFAM_HUMAN	transcription factor A, mitochondrial precursor	207	HMG box 2.				DNA-dependent DNA replication|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase I promoter|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	mitochondrial light strand promoter sense binding|protein binding|sequence-specific DNA binding transcription factor activity				0						TGCTAAAGAGGACGAAACTCG	0.289000													7	6					0	0	0.003080	0	0
GPR123	84435	broad.mit.edu	37	10	134912195	134912195	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr10:134912195C>T	uc001llx.3	+	4	619	c.183C>T	c.(181-183)TTC>TTT	p.F61F	GPR123_uc001llw.2_Silent_p.F781F	NM_001083909	NP_001077378	Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	61	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		ATTTCTGCTTCCACGCGGCCC	0.652000													26	8					0	0	0.003954	0	0
MUC2	4583	broad.mit.edu	37	11	1097738	1097738	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:1097738G>A	uc001lsx.1	+	39	13944	c.13917G>A	c.(13915-13917)GAG>GAA	p.E4639E		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	4639	VWFD 4.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CCAGCGGGGAGATCGTCTCCA	0.642000													12	14					0	0	0.001368	0	0
MRGPRE	116534	broad.mit.edu	37	11	3249685	3249685	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:3249685C>T	uc001lxq.3	-	2	652	c.342G>A	c.(340-342)GCG>GCA	p.A114A		NM_001039165	NP_001034254	Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	114	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(1)|ovary(1)	2		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)		CGCTGACGGCCGCCAGGAGAC	0.687000													4	11					0	0	0.000602	0	0
RRM1	6240	broad.mit.edu	37	11	4153577	4153577	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:4153577C>T	uc001lyw.3	+	16	2150	c.1831C>T	c.(1831-1833)CTG>TTG	p.L611L	RRM1_uc009yej.2_RNA|RRM1_uc009yei.2_Silent_p.L571L|RRM1_uc010qyc.1_Silent_p.L514L|RRM1_uc010qyd.1_Silent_p.L273L	NM_001033	NP_001024	P23921	RIR1_HUMAN	ribonucleoside-diphosphate reductase M1 chain	611					deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleoplasm|ribonucleoside-diphosphate reductase complex	ATP binding|ribonucleoside-diphosphate reductase activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.00502)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0848)|LUSC - Lung squamous cell carcinoma(625;0.205)	Clofarabine(DB00631)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Hydroxyurea(DB01005)	TGCTCAGATCCTGGGGAATAA	0.438000													10	38					0	0	0.006214	0	0
OR51E1	143503	broad.mit.edu	37	11	4674041	4674041	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:4674041C>T	uc001lzi.3	+	2	429	c.285C>T	c.(283-285)ATC>ATT	p.I95I		NM_152430	NP_689643	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|pancreas(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCACTACCATCCAGTTTGATG	0.473000													4	27					0	0	0.000602	0	0
DNHD1	144132	broad.mit.edu	37	11	6541243	6541243	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:6541243C>T	uc001mdw.3	+	9	2260	c.1696C>T	c.(1696-1698)CAT>TAT	p.H566Y	DNHD1_uc001mdp.2_Missense_Mutation_p.H566Y|DNHD1_uc001mdq.2_Missense_Mutation_p.H255Y	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	566					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CTTTGATGATCATGGTCAACT	0.463000													23	67					0	0	0.005443	0	0
ZNF215	7762	broad.mit.edu	37	11	6953513	6953513	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:6953513C>A	uc001mey.2	+	3	598	c.10C>A	c.(10-12)CTG>ATG	p.L4M	ZNF215_uc010raw.1_Missense_Mutation_p.L4M|ZNF215_uc010rax.1_Translation_Start_Site|ZNF215_uc001mez.1_Missense_Mutation_p.L4M	NM_013250	NP_037382	Q9UL58	ZN215_HUMAN	zinc finger protein 215	4					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		GATGCAGCCTCTGAGCAAGTT	0.453000													15	37					2.94398e-08	7.61241e-08	0.007413	1	0
OR10A3	26496	broad.mit.edu	37	11	7961032	7961032	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:7961032G>A	uc010rbi.1	-	1	36	c.36C>T	c.(34-36)TTC>TTT	p.F12F		NM_001003745	NP_001003745	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A,	12	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CCAGGAGGATGAATTCAACCA	0.398000													5	29					0	0	0.001168	0	0
C11orf16	56673	broad.mit.edu	37	11	8942870	8942870	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:8942870G>A	uc001mhb.3	-	6	1521	c.1397C>T	c.(1396-1398)TCC>TTC	p.S466F	C11orf16_uc001mhc.3_Intron	NM_020643	NP_065694	Q9NQ32	CK016_HUMAN	hypothetical protein LOC56673	466										upper_aerodigestive_tract(1)|pancreas(1)	2				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		AGTCTAACGGGAATTCTTGTT	0.463000													31	30					0	0	0.002836	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955459	18955459	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:18955459G>A	uc001mpg.2	-	1	1091	c.873C>T	c.(871-873)CTC>CTT	p.L291L		NM_147199	NP_671732	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	291	Cytoplasmic (Potential).				acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(2)|central_nervous_system(1)	3						GAGCCCTCTGGAGAACCAGCT	0.542000													10	34					0	0	0.008291	0	0
OR4C15	81309	broad.mit.edu	37	11	55322530	55322530	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:55322530C>T	uc010rig.1	+	1	748	c.748C>T	c.(748-750)CTC>TTC	p.L250F		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	196	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CATCTTTGGCCTCATGGTGGT	0.458000										HNSCC(20;0.049)			23	17					0	0	0.001882	0	0
OR4C11	219429	broad.mit.edu	37	11	55371330	55371330	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:55371330G>A	uc010rii.1	-	1	520	c.520C>T	c.(520-522)CAT>TAT	p.H174Y		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	174	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CAGCAATAATGATCAATCAAA	0.438000													22	18					0	0	0.001882	0	0
OR4C6	219432	broad.mit.edu	37	11	55433349	55433349	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:55433349C>T	uc001nht.3	+	3	972	c.707C>T	c.(706-708)TCT>TTT	p.S236F	OR4C6_uc010rik.1_Missense_Mutation_p.S236F	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	236	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						AAAGCCCTCTCTACCTGCAGC	0.493000													13	52					0	0	0.002450	0	0
OR5D18	219438	broad.mit.edu	37	11	55587908	55587908	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:55587908C>T	uc010rin.1	+	1	803	c.803C>T	c.(802-804)TCC>TTC	p.S268F		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	268	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				TCCAAAAACTCCAGGCACACA	0.507000													18	27					0	0	0.007413	0	0
OR5J2	282775	broad.mit.edu	37	11	55944548	55944548	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:55944548G>A	uc010rjb.1	+	1	455	c.455G>A	c.(454-456)GGA>GAA	p.G152E		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					TGGATAGGTGGAATAGTTAAC	0.453000													29	21					0	0	0.006320	0	0
OR5T1	390155	broad.mit.edu	37	11	56043514	56043514	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:56043514C>T	uc001nio.1	+	1	400	c.400C>T	c.(400-402)CGC>TGC	p.R134C		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	134	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					GGCTTATGATCGCTATGTAGC	0.413000													26	102					0	0	0.003954	0	0
OR5T1	390155	broad.mit.edu	37	11	56044034	56044034	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:56044034A>T	uc001nio.1	+	1	920	c.920A>T	c.(919-921)AAA>ATA	p.K307I		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	307	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					TTGCGGAACAAAGATGTAAAG	0.348000													26	38					0	0	0.005443	0	0
OR5M11	219487	broad.mit.edu	37	11	56310479	56310479	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:56310479G>A	uc010rjl.1	-	1	255	c.255C>T	c.(253-255)ATC>ATT	p.I85I		NM_001005245	NP_001005245	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M,	85	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCTCAGATACGATATTAGTCG	0.448000													22	28					0	0	0.001882	0	0
MS4A2	2206	broad.mit.edu	37	11	59860950	59860950	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:59860950G>A	uc001nop.2	+	5	558	c.456G>A	c.(454-456)CTG>CTA	p.L152L	MS4A2_uc009ymu.2_Silent_p.L152L	NM_000139	NP_000130	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member	152	Extracellular (Potential).				cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			ovary(1)	1		all_epithelial(135;0.245)			Omalizumab(DB00043)	TCATCAACCTGAAGAAGAGCT	0.438000													28	34					0	0	0.001786	0	0
SLC22A6	9356	broad.mit.edu	37	11	62751836	62751836	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:62751836C>T	uc001nwk.2	-	1	634	c.327G>A	c.(325-327)TGG>TGA	p.W109*	SLC22A6_uc001nwl.2_Nonsense_Mutation_p.W109*|SLC22A6_uc001nwj.2_Nonsense_Mutation_p.W109*|SLC22A6_uc001nwm.2_Nonsense_Mutation_p.W109*	NM_004790	NP_004781	Q4U2R8	S22A6_HUMAN	solute carrier family 22 member 6 isoform a	109	Extracellular (Potential).				alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding				0						TGTCATAGATCCAGCCATCGG	0.602000													16	49					0	0	0.004990	0	0
RPS6KA4	8986	broad.mit.edu	37	11	64137784	64137784	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:64137784C>T	uc001oae.2	+	15	1968	c.1885C>T	c.(1885-1887)CGC>TGC	p.R629C	RPS6KA4_uc001oad.2_Missense_Mutation_p.R623C|RPS6KA4_uc010rnl.1_Missense_Mutation_p.R566C|RPS6KA4_uc001oaf.2_Missense_Mutation_p.R622C|RPS6KA4_uc009ypp.2_Missense_Mutation_p.R381C	NM_003942	NP_003933	O75676	KS6A4_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	629	Protein kinase 2.				axon guidance|histone phosphorylation|interleukin-1-mediated signaling pathway|intracellular protein kinase cascade|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|magnesium ion binding|mitogen-activated protein kinase p38 binding|ribosomal protein S6 kinase activity			lung(3)|ovary(1)|breast(1)	5						GTGCAAAATCCGCGAGGGGCG	0.657000													18	62					0	0	0.006122	0	0
MALAT1	378938	broad.mit.edu	37	11	65272211	65272211	+	RNA	SNP	A	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:65272211A>G	uc010roh.1	+	1		c.6979A>G			uc001ody.2_5'Flank	NR_002819				Homo sapiens clone alpha1 mRNA sequence.												0						GGAAATGTTTAAACAGTTCAG	0.398000													11	34					0	0	0.001855	0	0
NPAS4	266743	broad.mit.edu	37	11	66191325	66191325	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:66191325C>T	uc001ohx.1	+	7	1140	c.964C>T	c.(964-966)CTC>TTC	p.L322F	NPAS4_uc010rpc.1_Missense_Mutation_p.L112F	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	322					transcription, DNA-dependent		DNA binding|signal transducer activity				0						AGCCTGGAGCCTCCGCCAGCA	0.547000													23	53					0	0	0.003330	0	0
C11orf30	56946	broad.mit.edu	37	11	76174919	76174919	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:76174919C>T	uc001oxl.2	+	7	769	c.626C>T	c.(625-627)TCT>TTT	p.S209F	C11orf30_uc009yuj.1_Missense_Mutation_p.S224F|C11orf30_uc010rsa.1_Missense_Mutation_p.S159F|C11orf30_uc001oxm.2_Missense_Mutation_p.S210F|C11orf30_uc010rsb.1_Missense_Mutation_p.S224F|C11orf30_uc010rsc.1_Missense_Mutation_p.S224F|C11orf30_uc001oxn.2_Missense_Mutation_p.S210F|C11orf30_uc010rsd.1_Missense_Mutation_p.S223F	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	209	Interaction with BRCA2.|Poly-Ser.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						CGAACAAACTCTTCCAGCTCC	0.443000													44	45					0	0	0.003610	0	0
CCDC83	220047	broad.mit.edu	37	11	85576199	85576199	+	Silent	SNP	T	C	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:85576199T>C	uc001pbh.1	+	2	545	c.33T>C	c.(31-33)GAT>GAC	p.D11D	CCDC83_uc001pbg.1_Silent_p.D11D	NM_173556	NP_775827	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	11										skin(1)	1		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				ATAAAAAGGATACACATGACG	0.363000													19	61					0	0	0.002780	0	0
FAT3	120114	broad.mit.edu	37	11	92085755	92085755	+	Silent	SNP	A	C	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:92085755A>C	uc001pdj.3	+	1	494	c.477A>C	c.(475-477)TCA>TCC	p.S159S		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	159	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CTTTGTTTTCACCCACAACAT	0.413000										TCGA Ovarian(4;0.039)			125	176					0	0	0.003610	0	0
RAD52	5893	broad.mit.edu	37	12	1034684	1034684	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:1034684C>T	uc001qis.1	-	7	589	c.475G>A	c.(475-477)GGG>AGG	p.G159R	RAD52_uc001qit.1_RNA|RAD52_uc010sdt.1_Missense_Mutation_p.G82R|RAD52_uc001qiu.1_Missense_Mutation_p.G159R|RAD52_uc001qiv.1_RNA|RAD52_uc001qiw.1_RNA|RAD52_uc010sdu.1_Missense_Mutation_p.G159R|RAD52_uc001qix.1_Nonsense_Mutation_p.W209*	NM_134424	NP_602296	P43351	RAD52_HUMAN	RAD52 homolog	159					DNA recombinase assembly|mitotic recombination|reciprocal meiotic recombination	nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1	all_cancers(10;0.0119)|all_epithelial(11;0.0171)|all_lung(10;0.0521)|Ovarian(42;0.0816)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.0323)			AGTGCATTCCCAAAACTCCTA	0.388000								Homologous_recombination					19	19					0	0	0.001523	0	0
CLEC4C	170482	broad.mit.edu	37	12	7890135	7890135	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:7890135G>A	uc001qtg.1	-	4	445	c.271C>T	c.(271-273)CAG>TAG	p.Q91*	CLEC4C_uc001qth.1_Nonsense_Mutation_p.Q91*|CLEC4C_uc001qti.1_Nonsense_Mutation_p.Q60*	NM_130441	NP_569708	Q8WTT0	CLC4C_HUMAN	C-type lectin domain family 4, member C isoform	91	Extracellular (Potential).|C-type lectin.				innate immune response	integral to membrane	sugar binding			ovary(2)|skin(1)	3				Kidney(36;0.0915)		CAACTAGACTGAAATGAAGTC	0.403000													32	38					0	0	0.004289	0	0
C12orf60	144608	broad.mit.edu	37	12	14976118	14976118	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:14976118G>A	uc001rcj.3	+	2	453	c.249G>A	c.(247-249)AAG>AAA	p.K83K		NM_175874	NP_787070	Q5U649	CL060_HUMAN	hypothetical protein LOC144608	83										ovary(1)|central_nervous_system(1)	2						AAATTCAAAAGGAGTCTTTAT	0.358000													17	49					0	0	0.004007	0	0
SOX5	6660	broad.mit.edu	37	12	23818467	23818467	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:23818467G>A	uc001rfw.2	-	7	944	c.842C>T	c.(841-843)CCC>CTC	p.P281L	SOX5_uc001rfx.2_Missense_Mutation_p.P268L|SOX5_uc001rfy.2_Missense_Mutation_p.P268L|SOX5_uc010siv.1_Missense_Mutation_p.P268L|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.P233L	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	281					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						AGGGAATACGGGAATCATTAA	0.512000													40	47					0	0	0.002852	0	0
IFLTD1	160492	broad.mit.edu	37	12	25679043	25679043	+	Missense_Mutation	SNP	G	C	C	rs145152190	by1000genomes	TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:25679043G>C	uc001rgs.2	-	5	875	c.725C>G	c.(724-726)CCG>CGG	p.P242R	IFLTD1_uc001rgt.1_Missense_Mutation_p.P145R|IFLTD1_uc010sji.1_Missense_Mutation_p.P263R|IFLTD1_uc010sjj.1_Missense_Mutation_p.P179R|IFLTD1_uc009zjc.2_Intron	NM_152590	NP_689803	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	242						intermediate filament	structural molecule activity			ovary(2)|central_nervous_system(1)	3	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					TTGACCGTTCGGTTTGCACAG	0.328000													7	39					0	0	0.008291	0	0
ACCN2	41	broad.mit.edu	37	12	50471139	50471139	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:50471139G>A	uc001rvw.2	+	4	931	c.702G>A	c.(700-702)GGG>GGA	p.G234G	ACCN2_uc001rvv.2_Silent_p.G234G|ACCN2_uc009zln.2_Silent_p.G25G|ACCN2_uc009zlo.2_Silent_p.G234G	NM_001095	NP_001086	P78348	ACCN2_HUMAN	amiloride-sensitive cation channel 2, neuronal	234	Extracellular (By similarity).				calcium ion transport|response to pH|signal transduction	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(1)	1					Amiloride(DB00594)	CTGTGTGGGGGGAGACTGGTA	0.642000													7	8					0	0	0.001984	0	0
LARP4	113251	broad.mit.edu	37	12	50860821	50860821	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:50860821C>T	uc001rwp.1	+	13	1607	c.1463C>T	c.(1462-1464)CCT>CTT	p.P488L	LARP4_uc001rwo.1_Missense_Mutation_p.P494L|LARP4_uc001rwq.1_Missense_Mutation_p.P417L|LARP4_uc001rwr.1_Missense_Mutation_p.P417L|LARP4_uc001rws.1_Missense_Mutation_p.P487L|LARP4_uc009zlr.1_Missense_Mutation_p.P307L|LARP4_uc001rwt.1_Missense_Mutation_p.P79L	NM_052879	NP_443111	Q71RC2	LARP4_HUMAN	c-Mpl binding protein isoform a	488							nucleotide binding|RNA binding			ovary(1)	1						CCACCTTTACCTGGAAGTTCA	0.383000													25	19					0	0	0.002780	0	0
KIAA0748	9840	broad.mit.edu	37	12	55356694	55356694	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:55356694G>A	uc001sgn.3	-	9	1098	c.988C>T	c.(988-990)CTC>TTC	p.L330F	KIAA0748_uc001sgl.3_Missense_Mutation_p.L192F|KIAA0748_uc001sgm.3_Missense_Mutation_p.L77F|KIAA0748_uc010spb.1_Missense_Mutation_p.L77F|KIAA0748_uc010spc.1_Missense_Mutation_p.L192F|KIAA0748_uc010spd.1_Missense_Mutation_p.L330F|KIAA0748_uc001sgo.3_RNA	NM_001098815	NP_001092285	A2RU30	K0748_HUMAN	hypothetical protein LOC9840	330										ovary(1)|central_nervous_system(1)	2						TCTTGCTGGAGGAACTGCTTC	0.522000													5	22					0	0	0.001168	0	0
BTBD11	121551	broad.mit.edu	37	12	108013885	108013885	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:108013885G>A	uc001tmk.1	+	11	3096	c.2575G>A	c.(2575-2577)GAG>AAG	p.E859K	BTBD11_uc009zut.1_Missense_Mutation_p.E740K|BTBD11_uc001tmj.2_Missense_Mutation_p.E859K|BTBD11_uc001tml.1_Missense_Mutation_p.E396K	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	859						integral to membrane	DNA binding			skin(2)|ovary(1)	3						GGAATACACGGAGGAGCTCGT	0.532000													18	24					0	0	0.001882	0	0
SLC24A6	80024	broad.mit.edu	37	12	113759054	113759054	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:113759054C>T	uc001tvc.2	-	3	466	c.256G>A	c.(256-258)GGC>AGC	p.G86S	SLC24A6_uc001tvd.1_Missense_Mutation_p.G86S|SLC24A6_uc001tuz.2_5'Flank|SLC24A6_uc001tva.2_5'Flank|SLC24A6_uc001tvb.2_5'Flank	NM_024959	NP_079235	Q6J4K2	NCKX6_HUMAN	solute carrier family 24 member 6 precursor	86	Extracellular (Potential).				response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			central_nervous_system(1)	1						CAGAAGATGCCTTCCAGGTAG	0.627000													16	59					0	0	0.004007	0	0
FBXO21	23014	broad.mit.edu	37	12	117603355	117603355	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:117603355C>G	uc001twk.2	-	9	1300	c.1261G>C	c.(1261-1263)GAC>CAC	p.D421H	FBXO21_uc001twj.2_Missense_Mutation_p.D421H|FBXO21_uc009zwq.2_Missense_Mutation_p.D361H|FBXO21_uc001twl.1_Missense_Mutation_p.D34H	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	421					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		TGCACCTGGTCCGGGTACATT	0.493000													19	37					0	0	0.007413	0	0
DHX37	57647	broad.mit.edu	37	12	125438543	125438543	+	Splice_Site	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:125438543C>T	uc001ugy.2	-	20	2678	c.2579_splice	c.e20-1	p.G860_splice	DHX37_uc001ugz.1_5'Flank	NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37								ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		CCCACGGCGCCTGGGGAACGA	0.657000													7	7					0	0	0.004482	0	0
IL17D	53342	broad.mit.edu	37	13	21296055	21296055	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr13:21296055C>T	uc001unm.2	+	3	679	c.571C>T	c.(571-573)CTC>TTC	p.L191F		NM_138284	NP_612141	Q8TAD2	IL17D_HUMAN	interleukin 17D precursor	191					inflammatory response	extracellular space	cytokine activity				0		all_cancers(29;9.63e-24)|all_epithelial(30;1.09e-19)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000301)|Epithelial(112;0.000633)|OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Lung(94;0.0154)|LUSC - Lung squamous cell carcinoma(192;0.0414)		GGGCGCCAAGCTCCTGCTGGG	0.721000													13	19					0	0	0.001855	0	0
FLT3	2322	broad.mit.edu	37	13	28588639	28588640	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr13:28588639_28588640GG>AA	uc001urw.2	-	23	2890_2891	c.2808_2809CC>TT	c.(2806-2811)TTCCCT>TTTTCT	p.P937S	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.P896S	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	937	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	GTCAAATTAGGGAAGGATGGCC	0.396000			Mis|O		AML|ALL								13	29					0	0	0.004672	0	0
FLT1	2321	broad.mit.edu	37	13	29004199	29004200	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr13:29004199_29004200GG>AA	uc001usb.3	-	8	1378_1379	c.1093_1094CC>TT	c.(1093-1095)CCG>TTG	p.P365L	FLT1_uc010aar.1_Missense_Mutation_p.P365L|FLT1_uc001usc.3_Missense_Mutation_p.P365L|FLT1_uc010tdp.1_Missense_Mutation_p.P365L	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	365	Ig-like C2-type 4.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TACAACTTCCGGCGAGGGAAAT	0.450000													25	55					0	0	0.004672	0	0
BRCA2	675	broad.mit.edu	37	13	32906615	32906615	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr13:32906615C>T	uc001uub.1	+	10	1227	c.1000C>T	c.(1000-1002)CAT>TAT	p.H334Y	BRCA2_uc001uua.1_Missense_Mutation_p.H211Y	NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	334					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AAAAATTTTCCATGAAGCAAA	0.294000			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			35	75					0	0	0.002836	0	0
FREM2	341640	broad.mit.edu	37	13	39263084	39263084	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr13:39263084C>T	uc001uwv.2	+	1	1912	c.1603C>T	c.(1603-1605)CGC>TGC	p.R535C		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	535	Extracellular (Potential).|CSPG 2.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CCTGGTGCTTCGCATGGTGGA	0.587000													5	15					0	0	0.000602	0	0
ZC3H13	23091	broad.mit.edu	37	13	46542938	46542938	+	Silent	SNP	T	C	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr13:46542938T>C	uc010tfw.1	-	13	3747	c.3741A>G	c.(3739-3741)AGA>AGG	p.R1247R	ZC3H13_uc001vaq.2_5'Flank|ZC3H13_uc001vas.1_Silent_p.R1247R|ZC3H13_uc001vat.1_Silent_p.R1247R	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	1247	Ser-rich.						nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TCCTAGATTTTCTCTCTCCTG	0.413000													39	79					0	0	0.003214	0	0
IPO5	3843	broad.mit.edu	37	13	98645159	98645159	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr13:98645159C>T	uc001vnf.1	+	7	748	c.683C>T	c.(682-684)TCG>TTG	p.S228L	IPO5_uc001vne.2_Missense_Mutation_p.S246L|IPO5_uc010tik.1_Missense_Mutation_p.S103L|IPO5_uc010til.1_Missense_Mutation_p.S168L	NM_002271	NP_002262	O00410	IPO5_HUMAN	importin 5	228	HEAT 1.				interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			ovary(1)|lung(1)|skin(1)	3						GTAAATGACTCGTGCTACCAG	0.408000													23	57					0	0	0.003330	0	0
OR4K1	79544	broad.mit.edu	37	14	20404452	20404452	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr14:20404452C>T	uc001vwj.1	+	1	627	c.627C>T	c.(625-627)AGC>AGT	p.S209S		NM_001004063	NP_001004063	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		TATCATTGAGCTGTTTCCTGG	0.443000													15	52					0	0	0.004007	0	0
NID2	22795	broad.mit.edu	37	14	52496283	52496283	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr14:52496283C>T	uc001wzo.2	-	10	2617	c.2383G>A	c.(2383-2385)GAT>AAT	p.D795N	NID2_uc010tqs.1_Missense_Mutation_p.D795N|NID2_uc010tqt.1_Missense_Mutation_p.D795N|NID2_uc001wzp.2_Missense_Mutation_p.D795N	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	795	EGF-like 2.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					TTCCGTCCATCTCCCTGGTAC	0.527000													27	54					0	0	0.007291	0	0
PCNX	22990	broad.mit.edu	37	14	71570253	71570253	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr14:71570253C>T	uc001xmo.2	+	32	6408	c.5962C>T	c.(5962-5964)CCT>TCT	p.P1988S	PCNX_uc010are.1_Missense_Mutation_p.P1877S|PCNX_uc010arf.1_Missense_Mutation_p.P776S|PCNX_uc001xmp.2_Missense_Mutation_p.P72S	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	1988						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TTGTGATCAACCTATTGGCTA	0.453000													20	59					0	0	0.002299	0	0
KCNK13	56659	broad.mit.edu	37	14	90651153	90651153	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr14:90651153G>A	uc001xye.1	+	2	1475	c.1033G>A	c.(1033-1035)GAG>AAG	p.E345K		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	345	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				GCTCTCAGGGGAGATGATCTC	0.617000													19	41					0	0	0.006122	0	0
PLD4	122618	broad.mit.edu	37	14	105394092	105394092	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr14:105394092C>T	uc001ypu.1	+	3	314	c.173C>T	c.(172-174)CCC>CTC	p.P58L	PLD4_uc010tyl.1_Missense_Mutation_p.P65L	NM_138790	NP_620145	Q96BZ4	PLD4_HUMAN	phospholipase D4	58					lipid catabolic process	integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity			central_nervous_system(1)|skin(1)	2		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.00067)|OV - Ovarian serous cystadenocarcinoma(23;0.00976)|Epithelial(46;0.0201)|GBM - Glioblastoma multiforme(11;0.116)		Choline(DB00122)	CCCCGTCCTCCCACCTGGGGC	0.687000													5	2					0	0	0.001168	0	0
ADAM6	8755	broad.mit.edu	37	14	106805642	106805642	+	RNA	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr14:106805642C>T	uc010tyt.1	-	359		c.13647G>A			uc001ysw.1_5'Flank					Parts of antibodies, mostly variable regions.												0						ACAGGTGTTTCATGTTCTTGC	0.522000													14	55					0	0	0.007413	0	0
RYR3	6263	broad.mit.edu	37	15	33955132	33955132	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:33955132G>A	uc001zhi.2	+	35	5471	c.5401G>A	c.(5401-5403)GAA>AAA	p.E1801K	RYR3_uc010bar.2_Missense_Mutation_p.E1801K	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1801	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCGATTACCCGAATCCGTCAA	0.493000													57	96					0	0	0.003610	0	0
TMCO5A	145942	broad.mit.edu	37	15	38234396	38234396	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:38234396A>G	uc001zjw.2	+	8	612	c.509A>G	c.(508-510)TAC>TGC	p.Y170C	TMCO5A_uc001zjv.1_Missense_Mutation_p.Y170C|TMCO5A_uc010bbc.1_Missense_Mutation_p.Y170C	NM_152453	NP_689666	Q8N6Q1	TMC5A_HUMAN	transmembrane and coiled-coil domains 5A	170	Potential.					integral to membrane				central_nervous_system(1)	1						TTGAAGAAGTACCAGGAAACG	0.363000													29	100					0	0	0.002096	0	0
C15orf23	90417	broad.mit.edu	37	15	40675118	40675118	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:40675118C>T	uc001zll.2	+	1	197	c.82C>T	c.(82-84)CCG>TCG	p.P28S	C15orf23_uc010ucp.1_Missense_Mutation_p.P28S|C15orf23_uc001zlo.2_Missense_Mutation_p.P28S|C15orf23_uc001zlm.2_RNA|C15orf23_uc001zln.2_RNA	NM_033286	NP_150628	Q9Y448	T4AF1_HUMAN	TRAF4 associated factor 1 isoform a	28						nucleus	protein binding			ovary(1)|skin(1)	2		all_cancers(109;2.34e-14)|all_epithelial(112;9.21e-12)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.39e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0798)		CCACCCACTTCCGCCTAGCTA	0.562000													19	24					0	0	0.007413	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42104844	42104844	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:42104844C>T	uc001zok.3	+	7	915	c.629C>T	c.(628-630)ACC>ATC	p.T210I	MAPKBP1_uc001zoj.3_Missense_Mutation_p.T210I|MAPKBP1_uc010bcj.2_5'UTR|MAPKBP1_uc010bci.2_Missense_Mutation_p.T210I|MAPKBP1_uc010udb.1_Missense_Mutation_p.T98I|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_5'UTR	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	210	WD 3.									central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		GACAGCAAGACCTCAAAGGTG	0.577000													13	26					0	0	0.002450	0	0
ELL3	80237	broad.mit.edu	37	15	44068348	44068348	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:44068348T>A	uc001zsw.1	-	3	573	c.170A>T	c.(169-171)TAT>TTT	p.Y57F	ELL3_uc001zsv.1_Missense_Mutation_p.Y11F|ELL3_uc001zsx.1_5'UTR|uc001zsy.2_5'Flank	NM_025165	NP_079441	Q9HB65	ELL3_HUMAN	elongation factor RNA polymerase II-like 3	57					positive regulation of transcription elongation, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				ovary(1)	1		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;7.81e-07)		GAGTCTCAGATACTGGGGGTG	0.607000													7	16					0	0	0.001984	0	0
SPESP1	246777	broad.mit.edu	37	15	69223007	69223008	+	Missense_Mutation	DNP	CC	TT	TT	rs150328243	byFrequency	TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:69223007_69223008CC>TT	uc002arn.1	+	1	143_144	c.15_16CC>TT	c.(13-18)GTCCTT>GTTTTT	p.L6F	NOX5_uc002arp.1_5'UTR|NOX5_uc002arq.1_5'UTR|NOX5_uc010bid.1_5'UTR|NOX5_uc002aro.2_RNA	NM_145658	NP_663633	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1 precursor	6					multicellular organismal development	acrosomal vesicle					0						AGCCCTTAGTCCTTCTAGTTGC	0.619000													48	82					0	0	0.004672	0	0
CT62	196993	broad.mit.edu	37	15	71403676	71403676	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:71403676C>T	uc002ata.2	-	4	738	c.225G>A	c.(223-225)AAG>AAA	p.K75K		NM_001102658	NP_001096128	P0C5K7	CT62_HUMAN	cancer/testis antigen 62	75											0						AGAATTTTCTCTTGCCCAGTT	0.522000													12	29					0	0	0.001855	0	0
MYO9A	4649	broad.mit.edu	37	15	72208774	72208774	+	Silent	SNP	A	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:72208774A>G	uc002atl.3	-	19	3095	c.2622T>C	c.(2620-2622)ATT>ATC	p.I874I	MYO9A_uc010biq.2_Silent_p.I494I|MYO9A_uc002atn.1_Silent_p.I855I	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	874					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						GAGACTTGGTAATGCGATCTT	0.348000													11	32					0	0	0.008291	0	0
CCDC33	80125	broad.mit.edu	37	15	74623062	74623062	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:74623062G>A	uc002axo.2	+	13	1909	c.1515G>A	c.(1513-1515)AGG>AGA	p.R505R	CCDC33_uc002axp.2_Silent_p.R327R|CCDC33_uc002axq.2_Silent_p.R98R|CCDC33_uc002axr.2_Silent_p.R98R	NM_025055	NP_079331	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33 isoform 1	708	Potential.						protein binding			ovary(3)|skin(2)	5						TGAGGGACAGGGTGCAGCATT	0.572000													9	30					0	0	0.006214	0	0
HMG20A	10363	broad.mit.edu	37	15	77759465	77759465	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:77759465A>G	uc002bcr.2	+	5	467	c.266A>G	c.(265-267)AAA>AGA	p.K89R	HMG20A_uc002bcs.2_Missense_Mutation_p.K89R	NM_018200	NP_060670	Q9NP66	HM20A_HUMAN	high-mobility group 20A	89					chromatin modification	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						GGTTGGTCCAAAGGAAGAAAG	0.308000													4	32					0	0	0.000248	0	0
LOC645752	645752	broad.mit.edu	37	15	78211648	78211648	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:78211648A>G	uc010bky.2	-	11	883	c.119T>C	c.(118-120)CTA>CCA	p.L40P		NR_027024				SubName: Full=GOLGA6 protein; Flags: Fragment;												0						CGCCAGGGATAGGGGCTCAGC	0.522000													3	42					0	0	0.004672	0	0
CHRNA3	1136	broad.mit.edu	37	15	78893932	78893932	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:78893932G>A	uc002bec.2	-	5	1238	c.1052C>T	c.(1051-1053)CCC>CTC	p.P351L	CHRNA3_uc002bea.2_RNA|CHRNA3_uc002beb.2_Missense_Mutation_p.P351L	NM_000743	NP_000734	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3	351	Cytoplasmic (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity	p.P351S(1)		central_nervous_system(3)|ovary(1)	4						CATGACCCTGGGGAGCAGGTT	0.552000													29	37					0	0	0.008361	0	0
ALPK3	57538	broad.mit.edu	37	15	85401094	85401094	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:85401094G>A	uc002ble.2	+	6	3898	c.3731G>A	c.(3730-3732)GGC>GAC	p.G1244D		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1244					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CGCCTCACCGGCCTCCTGGAC	0.682000													6	17					0	0	0.001984	0	0
NSMCE1	197370	broad.mit.edu	37	16	27238131	27238131	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr16:27238131G>A	uc002doi.1	-	6	608	c.510C>T	c.(508-510)GGC>GGT	p.G170G	NSMCE1_uc002doj.1_RNA	NM_145080	NP_659547	Q8WV22	NSE1_HUMAN	non-SMC element 1 homolog	170					DNA recombination|DNA repair|intracellular signal transduction	nucleus	zinc ion binding				0						GGATGGCCCGGCCGTGCAGGG	0.612000													34	50					0	0	0.006230	0	0
ZNF423	23090	broad.mit.edu	37	16	49669774	49669774	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr16:49669774C>T	uc002efs.2	-	5	3587	c.3289G>A	c.(3289-3291)GCC>ACC	p.A1097T	ZNF423_uc010vgn.1_Missense_Mutation_p.A980T	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	1097					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				GCGCTGCGGGCCATGCAGCCG	0.687000													11	8					0	0	0.000978	0	0
NOD2	64127	broad.mit.edu	37	16	50744798	50744798	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr16:50744798C>T	uc002egm.1	+	4	1081	c.976C>T	c.(976-978)CTC>TTC	p.L326F	NOD2_uc010cbk.1_Missense_Mutation_p.L299F|NOD2_uc002egl.1_Missense_Mutation_p.L104F|NOD2_uc010cbl.1_Missense_Mutation_p.L104F|NOD2_uc010cbm.1_Missense_Mutation_p.L104F|NOD2_uc010cbn.1_RNA|NOD2_uc010cbo.1_RNA|NOD2_uc010cbp.1_5'Flank|NOD2_uc010cbq.1_5'Flank|NOD2_uc010cbr.1_5'Flank	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	326	NACHT.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				CCAGGAATTTCTCTTTGTCTT	0.592000													10	22					0	0	0.001368	0	0
CDH8	1006	broad.mit.edu	37	16	61687849	61687849	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr16:61687849G>A	uc002eog.1	-	12	2315	c.2063C>T	c.(2062-2064)CCA>CTA	p.P688L		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	688	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		AATTCCATCTGGATTTTGTAA	0.423000													43	51					0	0	0.002522	0	0
DYNC1LI2	1783	broad.mit.edu	37	16	66770095	66770096	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr16:66770095_66770096GG>AA	uc002eqb.1	-	5	612_613	c.581_582CC>TT	c.(580-582)TCC>TTT	p.S194F	DYNC1LI2_uc010vis.1_Missense_Mutation_p.S117F|DYNC1LI2_uc010vit.1_Missense_Mutation_p.S194F|DYNC1LI2_uc010viu.1_Missense_Mutation_p.S155F	NM_006141	NP_006132	O43237	DC1L2_HUMAN	dynein, cytoplasmic, light intermediate	194					transport	centrosome|cytoplasmic dynein complex|microtubule	ATP binding|motor activity			central_nervous_system(3)|skin(1)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0907)|Epithelial(162;0.212)		TTCTCTGTGGGGAACCTTGACA	0.450000													16	34					0	0	0.004672	0	0
CDH13	1012	broad.mit.edu	37	16	83711854	83711854	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr16:83711854C>T	uc002fgx.2	+	10	1446	c.1326C>T	c.(1324-1326)ATC>ATT	p.I442I	CDH13_uc010vns.1_Silent_p.I489I|CDH13_uc010vnt.1_Silent_p.I188I|CDH13_uc010vnu.1_Silent_p.I403I	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	442	Cadherin 3.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		CCCTGCTGATCAAAGTGGAAA	0.552000													15	18					0	0	0.002450	0	0
ADAD2	161931	broad.mit.edu	37	16	84230550	84230550	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr16:84230550G>A	uc002fhr.2	+	10	1836	c.1722G>A	c.(1720-1722)TCG>TCA	p.S574S	ADAD2_uc002fhq.2_Silent_p.S656S|uc002fhs.1_5'UTR	NM_001145400	NP_001138872	Q8NCV1	ADAD2_HUMAN	adenosine deaminase domain containing 2 isoform	574	A to I editase.				RNA processing	intracellular	adenosine deaminase activity|double-stranded RNA binding				0						CTTGGCCCTCGAAGCCACTGG	0.667000													8	8					0	0	0.000978	0	0
KIAA0513	9764	broad.mit.edu	37	16	85105471	85105471	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr16:85105471C>T	uc002fiu.2	+	3	632	c.412C>T	c.(412-414)CGA>TGA	p.R138*	KIAA0513_uc002fis.3_Nonsense_Mutation_p.R138*|KIAA0513_uc010voj.1_Nonsense_Mutation_p.R138*|KIAA0513_uc002fit.2_Nonsense_Mutation_p.R138*	NM_014732	NP_055547	O60268	K0513_HUMAN	hypothetical protein LOC9764	138						cytoplasm				breast(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.234)		GTGGTTTGCTCGATACGTGAG	0.448000													11	22					0	0	0.001368	0	0
DNAH2	146754	broad.mit.edu	37	17	7678115	7678115	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:7678115G>A	uc002giu.1	+	28	4554	c.4540G>A	c.(4540-4542)GAA>AAA	p.E1514K		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1514	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TACAATCCTGGAAGATATTCA	0.448000													10	29					0	0	0.000978	0	0
DNAH2	146754	broad.mit.edu	37	17	7708669	7708669	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:7708669C>T	uc002giu.1	+	60	9414	c.9400C>T	c.(9400-9402)CGA>TGA	p.R3134*	DNAH2_uc010cnm.1_Nonsense_Mutation_p.R72*	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	3134	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TATGATTCTTCGAGGCAACGA	0.438000													8	33					0	0	0.004482	0	0
MYH2	4620	broad.mit.edu	37	17	10430031	10430031	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:10430031C>T	uc010coi.2	-	30	4200	c.4072G>A	c.(4072-4074)GAA>AAA	p.E1358K	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.E1358K|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1358	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						GCCTTGGATTCCTGCTCCTCC	0.607000													37	29					0	0	0.006999	0	0
DNAH9	1770	broad.mit.edu	37	17	11650910	11650910	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:11650910C>T	uc002gne.2	+	32	6505	c.6437C>T	c.(6436-6438)TCT>TTT	p.S2146F	DNAH9_uc010coo.2_Missense_Mutation_p.S1440F	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2146	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GTGCGGCACTCTGTATTTGTG	0.597000													11	18					0	0	0.002450	0	0
GRB7	2886	broad.mit.edu	37	17	37898848	37898848	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:37898848C>T	uc002hsr.2	+	3	435	c.185C>T	c.(184-186)ACC>ATC	p.T62I	GRB7_uc002hss.2_Missense_Mutation_p.T62I|GRB7_uc010cwc.2_Missense_Mutation_p.T62I|GRB7_uc002hst.2_Missense_Mutation_p.T62I	NM_005310	NP_005301	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	62					blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			AGGCGTGCCACCTCCCTCCCC	0.612000													19	66					0	0	0.001882	0	0
KRTAP17-1	83902	broad.mit.edu	37	17	39471786	39471786	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:39471786C>T	uc002hwj.2	-	1	162	c.117G>A	c.(115-117)GGG>GGA	p.G39G		NM_031964	NP_114170	Q9BYP8	KR171_HUMAN	keratin associated protein 17-1	39						intermediate filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			agccagagcccccacagccac	0.194000													3	8					0	0	0.004672	0	0
JUP	3728	broad.mit.edu	37	17	39680045	39680045	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:39680045C>T	uc010wfs.1	-	9	1650	c.1642G>A	c.(1642-1644)GAG>AAG	p.E548K	KRT15_uc002hxb.1_5'Flank|uc002hxc.1_5'Flank|KRT19_uc002hxd.3_Missense_Mutation_p.E385K	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	Error:Variant_position_missing_in_P14923_after_alignment					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		TCCTGTCCCTCGAGCAGGCTG	0.577000													5	21					0	0	0.000602	0	0
ITGB3	3690	broad.mit.edu	37	17	45360877	45360877	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:45360877A>G	uc002ilj.2	+	3	343	c.323A>G	c.(322-324)CAA>CGA	p.Q108R	ITGB3_uc002ili.1_Missense_Mutation_p.Q108R|ITGB3_uc010wkr.1_RNA	NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	108	Extracellular (Potential).				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)	CAGGTCACTCAAGTCAGTCCC	0.612000													17	26					0	0	0.006122	0	0
EPN3	55040	broad.mit.edu	37	17	48614370	48614370	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:48614370G>A	uc002ira.3	+	2	888	c.453G>A	c.(451-453)AAG>AAA	p.K151K	EPN3_uc010wms.1_Silent_p.K206K|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Silent_p.K151K	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	151						clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			TCAAGACCAAGGAGCGCATGG	0.677000													6	3					0	0	0.001168	0	0
NOL11	25926	broad.mit.edu	37	17	65732798	65732798	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:65732798C>T	uc002jgd.1	+	10	1074	c.1071C>T	c.(1069-1071)TCC>TCT	p.S357S	NOL11_uc010wql.1_Silent_p.S175S|NOL11_uc010deu.1_5'UTR	NM_015462	NP_056277	Q9H8H0	NOL11_HUMAN	nucleolar protein 11	357						nucleolus					0	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)			ATGTCGTGTCCCATTTTGTAA	0.358000													4	22					0	0	0.000602	0	0
SEC14L1	6397	broad.mit.edu	37	17	75190974	75190974	+	Silent	SNP	C	T	T	rs138582657		TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:75190974C>T	uc002jto.2	+	7	957	c.690C>T	c.(688-690)CCC>CCT	p.P230P	SEC14L1_uc010dhc.2_Silent_p.P230P|SEC14L1_uc010wth.1_Silent_p.P230P|SEC14L1_uc002jtm.2_Silent_p.P230P|SEC14L1_uc010wti.1_Silent_p.P196P	NM_003003	NP_002994	Q92503	S14L1_HUMAN	SEC14 (S. cerevisiae)-like 1 isoform a	230					transport	Golgi apparatus|integral to membrane	binding			ovary(2)	2						CACCTGAGCCCGTGGTGGGCA	0.632000													39	50					0	0	0.004878	0	0
MYOM1	8736	broad.mit.edu	37	18	3116406	3116406	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr18:3116406C>T	uc002klp.2	-	21	3560	c.3226G>A	c.(3226-3228)GAC>AAC	p.D1076N	MYOM1_uc002klq.2_Missense_Mutation_p.D980N	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	1076	Fibronectin type-III 5.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						TCCTTCAAGTCCACGAAGTAA	0.537000													10	20					0	0	0.008291	0	0
DCC	1630	broad.mit.edu	37	18	50278518	50278518	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr18:50278518C>T	uc002lfe.1	+	2	773	c.186C>T	c.(184-186)TCC>TCT	p.S62S	DCC_uc010xdr.1_5'UTR	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	62	Extracellular (Potential).|Ig-like C2-type 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TCGACTGCTCCGCGGAGTCCG	0.502000													15	13					0	0	0.003163	0	0
NEDD4L	23327	broad.mit.edu	37	18	56024451	56024452	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr18:56024451_56024452CC>TT	uc002lgy.2	+	19	2008_2009	c.1734_1735CC>TT	c.(1732-1737)GACCCA>GATTCA	p.P579S	NEDD4L_uc002lgz.2_Missense_Mutation_p.P515S|NEDD4L_uc002lgx.2_Missense_Mutation_p.P559S|NEDD4L_uc010xee.1_Missense_Mutation_p.P458S|NEDD4L_uc002lhc.2_Missense_Mutation_p.P571S|NEDD4L_uc002lhd.2_Missense_Mutation_p.P458S|NEDD4L_uc002lhb.2_Missense_Mutation_p.P438S|NEDD4L_uc002lhe.2_Missense_Mutation_p.P551S|NEDD4L_uc002lhf.2_Missense_Mutation_p.P438S|NEDD4L_uc002lhg.2_Missense_Mutation_p.P458S|NEDD4L_uc002lhh.2_Missense_Mutation_p.P354S|NEDD4L_uc010dpm.1_Missense_Mutation_p.P260S	NM_001144967	NP_001138439	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally	579	WW 4.				cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			lung(4)	4						AGTGGGAAGACCCAAGACTGCA	0.327000													11	9					0	0	0.004672	0	0
CCDC102B	79839	broad.mit.edu	37	18	66564501	66564501	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr18:66564501G>A	uc002lkk.2	+	8	1322	c.1099G>A	c.(1099-1101)GAA>AAA	p.E367K	CCDC102B_uc002lki.2_Missense_Mutation_p.E367K|CCDC102B_uc002lkj.1_Missense_Mutation_p.E367K	NM_001093729	NP_001087198	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	367	Potential.									ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				GGACAAGAGGGAAATACTTGA	0.403000													9	53					0	0	0.000978	0	0
GALR1	2587	broad.mit.edu	37	18	74963119	74963119	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr18:74963119C>T	uc002lms.3	+	1	1112	c.615C>T	c.(613-615)TTC>TTT	p.F205F		NM_001480	NP_001471	P47211	GALR1_HUMAN	galanin receptor 1	205	Helical; Name=5; (Potential).				digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			lung(1)	1		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		TGTGCACCTTCGTCTTCGGCT	0.687000													10	70					0	0	0.001368	0	0
MUC16	94025	broad.mit.edu	37	19	9060576	9060576	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:9060576G>A	uc002mkp.2	-	3	27074	c.26870C>T	c.(26869-26871)CCA>CTA	p.P8957L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8959	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGGAGGCCTGGATAAGAGGA	0.468000													71	65					0	0	0.003610	0	0
ZNF441	126068	broad.mit.edu	37	19	11892313	11892313	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:11892313C>T	uc010dyj.2	+	4	1868	c.1674C>T	c.(1672-1674)CCC>CCT	p.P558P	ZNF441_uc002msn.3_Silent_p.P514P	NM_152355	NP_689568	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	558					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GAGAGAAACCCTATGGTTGTC	0.413000													9	13					0	0	0.000978	0	0
CYP4F2	8529	broad.mit.edu	37	19	15990464	15990464	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:15990464T>C	uc002nbs.1	-	11	1314	c.1264A>G	c.(1264-1266)ATC>GTC	p.I422V	CYP4F2_uc010xot.1_Missense_Mutation_p.I273V	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	422					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						AAAACACTGATGAGGCAGATA	0.597000													35	48					0	0	0.004878	0	0
TPM4	7171	broad.mit.edu	37	19	16178515	16178515	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:16178515G>A	uc002ndi.2	+	1	199	c.81G>A	c.(79-81)GCG>GCA	p.A27A		NM_001145160	NP_001138632	P67936	TPM4_HUMAN	tropomyosin 4 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cellular component movement|muscle filament sliding|response to oxidative stress	cytosol|muscle thin filament tropomyosin|stress fiber	actin binding|calcium ion binding|structural constituent of muscle		TPM4/ALK(12)	soft_tissue(10)|haematopoietic_and_lymphoid_tissue(2)|breast(1)	13						AGGCGGAGGCGGATAAGAAAG	0.642000			T	ALK	ALCL								7	29					0	0	0.003080	0	0
NCAN	1463	broad.mit.edu	37	19	19338385	19338385	+	Silent	SNP	C	T	T	rs149325641		TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:19338385C>T	uc002nlz.2	+	8	2055	c.1956C>T	c.(1954-1956)ACC>ACT	p.T652T	NCAN_uc010ecc.1_Silent_p.T216T	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	652					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			CCATCTCCACCGAGGCCAATA	0.617000													17	50					0	0	0.004990	0	0
ZNF100	163227	broad.mit.edu	37	19	21909497	21909497	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:21909497G>A	uc002nqi.2	-	5	1816	c.1617C>T	c.(1615-1617)ACC>ACT	p.T539T	ZNF100_uc002nqh.2_Silent_p.T475T	NM_173531	NP_775802	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	539					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACATTTGTAGGGTTTCTCTCC	0.368000													12	17					0	0	0.000978	0	0
CCDC123	84902	broad.mit.edu	37	19	33444550	33444550	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:33444550C>T	uc002nty.2	-	4	552	c.463G>A	c.(463-465)GAC>AAC	p.D155N	CCDC123_uc002ntx.2_5'UTR|CCDC123_uc010edg.2_RNA|CCDC123_uc002ntz.1_Missense_Mutation_p.D155N|CCDC123_uc002nua.2_Missense_Mutation_p.D155N|CCDC123_uc002nub.1_Missense_Mutation_p.D47N	NM_032816	NP_116205	Q96ST8	CEP89_HUMAN	coiled-coil domain containing 123	155						centrosome|spindle pole					0	Esophageal squamous(110;0.137)					GCGTACAGGTCATCACTGTGG	0.488000													12	362					0	0	0.008871	0	0
ZNF790	388536	broad.mit.edu	37	19	37314681	37314681	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:37314681G>A	uc002oew.2	-	3	140	c.21C>T	c.(19-21)TTC>TTT	p.F7F	uc002oev.1_RNA	NM_206894	NP_996777	Q6PG37	ZN790_HUMAN	zinc finger protein 790	7	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			CCACATCCCTGAACATCATCA	0.393000													12	26					0	0	0.000978	0	0
CEACAM6	4680	broad.mit.edu	37	19	42270134	42270134	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:42270134G>A	uc002orm.2	+	5	1151	c.1002G>A	c.(1000-1002)ACG>ACA	p.T334T		NM_002483	NP_002474	P40199	CEAM6_HUMAN	carcinoembryonic antigen-related cell adhesion	334					cell-cell signaling|signal transduction	anchored to membrane|integral to plasma membrane				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(3;0.00575)|all cancers(3;0.0352)|Epithelial(262;0.0797)		TCGGCATCACGATTGGAGTGC	0.522000													11	50					0	0	0.002450	0	0
NKG7	4818	broad.mit.edu	37	19	51875054	51875055	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:51875054_51875055GG>AA	uc002pwj.2	-	4	645_646	c.474_475CC>TT	c.(472-477)CCCCGT>CCTTGT	p.R159C	CLDND2_uc002pwi.1_5'Flank|NKG7_uc002pwk.2_Missense_Mutation_p.R124C	NM_005601	NP_005592	Q16617	NKG7_HUMAN	natural killer cell group 7 sequence	159						integral to plasma membrane				central_nervous_system(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000211)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TAGCCAGGACGGGGACCGCCAC	0.584000													29	116					0	0	0.004672	0	0
MIR525	574470	broad.mit.edu	37	19	54200822	54200822	+	RNA	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:54200822C>T	hsa-mir-525|MI0003152	+			c.36C>T			MIR523_hsa-mir-523|MI0003153_5'Flank|MIR518F_hsa-mir-518f|MI0003154_5'Flank																	0						TGCACTTTCTCTTATGTGAAA	0.433000													14	21					0	0	0.001855	0	0
MIR521-1	574494	broad.mit.edu	37	19	54251937	54251937	+	RNA	SNP	G	A	A	rs2561251		TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:54251937G>A	hsa-mir-521-1|MI0003176	+			c.48G>A			MIR522_hsa-mir-522|MI0003177_5'Flank																	0						TTGTCTAAAAGAAAAGAACGC	0.428000													10	32					0	0	0.006214	0	0
LILRA1	11024	broad.mit.edu	37	19	55106777	55106777	+	Missense_Mutation	SNP	C	T	T	rs141328341		TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:55106777C>T	uc002qgh.1	+	5	753	c.571C>T	c.(571-573)CGC>TGC	p.R191C	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Missense_Mutation_p.R191C	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	191	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		GAGCCCGAGTCGCAGGTGGTC	0.567000													29	80					0	0	0.005443	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55378096	55378096	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:55378096C>T	uc002qhl.3	+	9	1341	c.1278C>T	c.(1276-1278)AGC>AGT	p.S426S	KIR3DL2_uc010esh.2_Silent_p.S409S|KIR3DL2_uc002qho.3_Silent_p.S426S			P43629	KI3L1_HUMAN	SubName: Full=KIR3DS1;	426	Cytoplasmic (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		CAGATACCAGCGTGTACACGG	0.522000													78	101					0	0	0.003610	0	0
NLRP7	199713	broad.mit.edu	37	19	55452999	55452999	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:55452999G>A	uc002qih.3	-	2	157	c.81C>T	c.(79-81)TCC>TCT	p.S27S	NLRP7_uc002qig.3_Silent_p.S27S|NLRP7_uc002qii.3_Silent_p.S27S|NLRP7_uc010esk.2_Silent_p.S27S|NLRP7_uc010esl.2_Silent_p.S55S	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	27	DAPIN.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		CCCATAAAAGGGATTTGAAAC	0.502000													10	27					0	0	0.000978	0	0
PEG3	5178	broad.mit.edu	37	19	57328195	57328195	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:57328195C>T	uc002qnu.2	-	7	1966	c.1615G>A	c.(1615-1617)GAA>AAA	p.E539K	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.E510K|PEG3_uc002qnv.2_Missense_Mutation_p.E539K|PEG3_uc002qnw.2_Missense_Mutation_p.E415K|PEG3_uc002qnx.2_Missense_Mutation_p.E413K|PEG3_uc010etr.2_Missense_Mutation_p.E539K	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	539					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TCCTCACATTCCTGATTCTTA	0.443000													21	71					0	0	0.001523	0	0
DUXA	503835	broad.mit.edu	37	19	57666694	57666694	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:57666694C>T	uc002qoa.1	-	5	530	c.485G>A	c.(484-486)AGG>AAG	p.R162K		NM_001012729	NP_001012747	A6NLW8	DUXA_HUMAN	double homeobox A	162						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		CACAGGTTCCCTTTTTCTCTG	0.413000													7	42					0	0	0.001984	0	0
NT5C1B	93034	broad.mit.edu	37	2	18766242	18766242	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:18766242G>A	uc002rcz.2	-	5	545	c.441C>T	c.(439-441)CTC>CTT	p.L147L	NT5C1B_uc002rcy.2_Silent_p.L147L|NT5C1B_uc010exr.2_Silent_p.L89L|NT5C1B_uc010yju.1_Silent_p.L87L|NT5C1B_uc002rda.2_Silent_p.L87L|NT5C1B_uc010yjv.1_Silent_p.L164L|NT5C1B_uc010yjw.1_Silent_p.L130L|NT5C1B_uc010exs.2_Silent_p.L149L|NT5C1B_uc002rdb.1_5'UTR	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	147	Ser-rich.				purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				AGCTGCTGGGGAGCTGCAGCA	0.637000													4	17					0	0	0.000248	0	0
APOB	338	broad.mit.edu	37	2	21260931	21260931	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:21260931C>T	uc002red.2	-	5	564	c.436G>A	c.(436-438)GAG>AAG	p.E146K		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	146	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCATCTTTCTCCGGGTAAAGG	0.493000													133	175					0	0	0.003610	0	0
PREB	10113	broad.mit.edu	37	2	27355501	27355501	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:27355501G>A	uc002rix.1	-	5	975	c.722C>T	c.(721-723)TCC>TTC	p.S241F	PREB_uc002riy.1_Missense_Mutation_p.S169F|PREB_uc002riz.1_RNA|PREB_uc002rja.1_Missense_Mutation_p.S241F	NM_013388	NP_037520	Q9HCU5	PREB_HUMAN	prolactin regulatory element binding protein	241	Cytoplasmic (Potential).				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|nucleus	DNA binding|guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGTGTGCTGGAAAAGGTGGG	0.567000													10	28					0	0	0.008291	0	0
RASGRP3	25780	broad.mit.edu	37	2	33774770	33774770	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:33774770G>A	uc002rox.2	+	15	2121	c.1494G>A	c.(1492-1494)CAG>CAA	p.Q498Q	RASGRP3_uc010ync.1_Silent_p.Q498Q|RASGRP3_uc002roy.2_Silent_p.Q497Q	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	498	Phorbol-ester/DAG-type.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					ATAATTTTCAGGAGATGACCT	0.403000													13	20					0	0	0.001368	0	0
CYP1B1	1545	broad.mit.edu	37	2	38301675	38301675	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:38301675C>T	uc002rqo.2	-	3	1260	c.857G>A	c.(856-858)GGG>GAG	p.G286E		NM_000104	NP_000095	Q16678	CP1B1_HUMAN	cytochrome P450, family 1, subfamily B,	286					visual perception|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			ovary(1)|central_nervous_system(1)	2		all_hematologic(82;0.21)			Estrone(DB00655)	gggggcggccccgggccgAAG	0.517000													3	11					0	0	0.000248	0	0
SLC8A1	6546	broad.mit.edu	37	2	40366808	40366808	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:40366808C>T	uc002rrx.2	-	9	2302	c.2278G>A	c.(2278-2280)GAT>AAT	p.D760N	uc002rrw.2_Intron|SLC8A1_uc002rry.2_Missense_Mutation_p.D755N|SLC8A1_uc002rrz.2_Missense_Mutation_p.D747N|SLC8A1_uc002rsa.2_Missense_Mutation_p.D724N|SLC8A1_uc002rsd.3_Missense_Mutation_p.D724N	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	760	Cytoplasmic (Potential).|Poly-Asp.				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TCGTCGTCATCATCTTCCCCT	0.502000													27	43					0	0	0.002445	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656466	40656466	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:40656466C>T	uc002rrx.2	-	1	979	c.955G>A	c.(955-957)GAT>AAT	p.D319N	SLC8A1_uc002rry.2_Missense_Mutation_p.D319N|SLC8A1_uc002rrz.2_Missense_Mutation_p.D319N|SLC8A1_uc002rsa.2_Missense_Mutation_p.D319N|SLC8A1_uc002rsd.3_Missense_Mutation_p.D319N|SLC8A1_uc002rsb.1_Missense_Mutation_p.D319N|SLC8A1_uc010fan.1_Missense_Mutation_p.D319N|SLC8A1_uc002rsc.1_Missense_Mutation_p.D319N	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	319	Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	GCTTCTTCATCATCTTGGTCC	0.398000													31	53					0	0	0.002445	0	0
PREPL	9581	broad.mit.edu	37	2	44570899	44570899	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:44570899T>C	uc002ruf.2	-	4	636	c.601A>G	c.(601-603)AAT>GAT	p.N201D	PREPL_uc002rug.2_Missense_Mutation_p.N201D|PREPL_uc002ruh.2_Missense_Mutation_p.N201D|PREPL_uc010fax.2_Missense_Mutation_p.N201D|PREPL_uc002rui.3_Missense_Mutation_p.N112D|PREPL_uc002ruj.1_Missense_Mutation_p.N112D|PREPL_uc002ruk.1_Missense_Mutation_p.N201D	NM_006036	NP_006027	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like isoform C	201					proteolysis	cytosol	serine-type endopeptidase activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CTGGACACATTCGGGAAAGAA	0.423000													13	56					0	0	0.004007	0	0
NRXN1	9378	broad.mit.edu	37	2	50758484	50758484	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:50758484G>A	uc010fbq.2	-	11	3825	c.2348C>T	c.(2347-2349)TCC>TTC	p.S783F	NRXN1_uc002rxb.3_Missense_Mutation_p.S415F|NRXN1_uc002rxe.3_Missense_Mutation_p.S743F|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GAACCGTAAGGAAACATCCTC	0.512000													4	15					0	0	0.000248	0	0
CHAC2	494143	broad.mit.edu	37	2	53995093	53995093	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:53995093T>A	uc002rxk.1	+	1	165	c.70T>A	c.(70-72)TAC>AAC	p.Y24N	ASB3_uc002rxg.1_Intron|ASB3_uc002rxh.1_Intron|ASB3_uc002rxi.3_Intron|ASB3_uc010yoo.1_Intron	NM_001008708	NP_001008708	Q8WUX2	CHAC2_HUMAN	ChaC, cation transport regulator-like 2	24											0			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GCTGGTCGGATACATCACCAA	0.627000											OREG0014616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	33					0	0	0.001984	0	0
CCDC142	84865	broad.mit.edu	37	2	74709731	74709731	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:74709731G>A	uc002slr.2	-	1	627	c.234C>T	c.(232-234)CCC>CCT	p.P78P	TTC31_uc002sls.2_5'Flank|TTC31_uc010yrv.1_5'Flank|TTC31_uc002slt.2_5'Flank|TTC31_uc002slu.2_5'Flank|CCDC142_uc002slo.2_RNA|CCDC142_uc002slq.2_Silent_p.P78P|CCDC142_uc002slp.2_Silent_p.P78P	NM_032779	NP_116168	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	78										central_nervous_system(1)	1						CGCCACCTGCGGGCCCCCGCC	0.741000													11	5					0	0	0.003163	0	0
FAHD2A	51011	broad.mit.edu	37	2	96072778	96072778	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:96072778G>A	uc002sur.2	+	3	514	c.335G>A	c.(334-336)GGC>GAC	p.G112D	FAHD2A_uc002sus.2_Missense_Mutation_p.G112D	NM_016044	NP_057128	Q96GK7	FAH2A_HUMAN	fumarylacetoacetate hydrolase domain containing	112							hydrolase activity|metal ion binding			ovary(1)	1						GTGTGTGTGGGCATGAATTAT	0.567000													4	57					0	0	0.000602	0	0
TGFBRAP1	9392	broad.mit.edu	37	2	105915055	105915055	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:105915055C>G	uc002tcq.2	-	3	880	c.796G>C	c.(796-798)GAA>CAA	p.E266Q	TGFBRAP1_uc010fjc.2_Missense_Mutation_p.E36Q|TGFBRAP1_uc002tcr.3_Missense_Mutation_p.E266Q	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor	266	CNH.				regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|skin(1)	2						GTGATGAATTCGTCATCGAGC	0.542000													25	66					0	0	0.007291	0	0
PCDP1	200373	broad.mit.edu	37	2	120369228	120369228	+	Splice_Site	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:120369228G>A	uc002tmb.2	+	14	1456	c.364_splice	c.e14-1	p.L122_splice	PCDP1_uc010yyq.1_Splice_Site_p.L252_splice	NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1							cilium	calmodulin binding				0	Colorectal(110;0.196)					TAAAAACCCAGCTAGACAGAG	0.348000													9	28					0	0	0.008291	0	0
MAP3K2	10746	broad.mit.edu	37	2	128083323	128083324	+	Missense_Mutation	DNP	GT	AA	AA			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:128083323_128083324GT>AA	uc002toj.1	-	8	722_723	c.657_658AC>TT	c.(655-660)TCACTT>TCTTTT	p.L220F	MAP3K2_uc010flz.1_Missense_Mutation_p.L220F	NM_006609	NP_006600	Q9Y2U5	M3K2_HUMAN	mitogen-activated protein kinase kinase kinase	220					activation of JUN kinase activity|cellular response to mechanical stimulus	nucleus	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein kinase binding			lung(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0706)		GGACTATCAAGTGATGGACAAC	0.287000													23	56					0	0	0.004672	0	0
NCRNA00164	554226	broad.mit.edu	37	2	132905758	132905758	+	RNA	SNP	C	T	T	rs62165773	by1000genomes	TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:132905758C>T	uc002tti.3	-	7		c.1133G>A			NCRNA00164_uc002ttj.3_RNA	NR_027019				Homo sapiens non-protein coding RNA 164, mRNA (cDNA clone IMAGE:5169389), with apparent retained intron.												0						GTGTTCTTTCCGCCAAGGGTG	0.438000													5	21					0	0	0.001168	0	0
THSD7B	80731	broad.mit.edu	37	2	137852477	137852477	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:137852477C>T	uc002tva.1	+	3	892	c.892C>T	c.(892-894)CAG>TAG	p.Q298*	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Nonsense_Mutation_p.Q188*	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		ATTGACTGTTCAGTCCTGCAT	0.458000													7	99					0	0	0.004482	0	0
SCN3A	6328	broad.mit.edu	37	2	165986630	165986630	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:165986630C>T	uc002ucx.2	-	17	3234	c.2742G>A	c.(2740-2742)AAG>AAA	p.K914K	SCN3A_uc002ucy.2_Silent_p.K865K|SCN3A_uc002ucz.2_Silent_p.K865K|SCN3A_uc002uda.1_Silent_p.K734K|SCN3A_uc002udb.1_Silent_p.K734K	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	914						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	CATCATTGATCTTGCAGACAC	0.498000													35	61					0	0	0.003610	0	0
SCN1A	6323	broad.mit.edu	37	2	166911222	166911222	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:166911222C>T	uc010zcz.1	-	4	546	c.528G>A	c.(526-528)AGG>AGA	p.R176R	SCN1A_uc002udo.3_Silent_p.R45R|SCN1A_uc010fpk.2_Silent_p.R45R	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	176	I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AACAGAATCCCCTTGCAATAA	0.323000													3	13					0	0	0.004672	0	0
TTN	7273	broad.mit.edu	37	2	179587548	179587548	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:179587548C>T	uc010zfg.1	-	73	18570	c.18346G>A	c.(18346-18348)GAT>AAT	p.D6116N	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.D2777N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7043							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATTTGGTATCTCCTTTGTAC	0.428000													13	11					0	0	0.003163	0	0
TTN	7273	broad.mit.edu	37	2	179611474	179611474	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:179611474C>T	uc002unb.2	-	46	15877	c.15653G>A	c.(15652-15654)CGA>CAA	p.R5218Q	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R5218C(1)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGATTTATTTCGATACCATTT	0.373000													14	25					0	0	0.001855	0	0
STAT4	6775	broad.mit.edu	37	2	191905853	191905853	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:191905853C>T	uc002usm.1	-	15	1527	c.1273G>A	c.(1273-1275)GAA>AAA	p.E425K	STAT4_uc002usn.1_Missense_Mutation_p.E425K|STAT4_uc010zgk.1_Missense_Mutation_p.E270K|STAT4_uc002uso.2_Missense_Mutation_p.E425K	NM_003151	NP_003142	Q14765	STAT4_HUMAN	signal transducer and activator of transcription	425					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(3)|skin(2)|lung(1)|ovary(1)|prostate(1)|pancreas(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			GAATGAAGTTCTTCAGTCACC	0.363000													24	52					0	0	0.003954	0	0
AAMP	14	broad.mit.edu	37	2	219131697	219131697	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:219131697G>A	uc002vhk.2	-	4	491	c.407C>T	c.(406-408)TCT>TTT	p.S136F	AAMP_uc002vhj.2_Missense_Mutation_p.S117F|AAMP_uc010fvo.2_Missense_Mutation_p.S136F|AAMP_uc002vhl.2_Missense_Mutation_p.S137F	NM_001087	NP_001078	Q13685	AAMP_HUMAN	angio-associated, migratory cell protein	136	WD 2.				angiogenesis|cell differentiation|positive regulation of endothelial cell migration|smooth muscle cell migration	cell surface|cytoplasm|plasma membrane	heparin binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;7.19e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACAAGTCACAGAGTCTTTATG	0.507000													11	26					0	0	0.000978	0	0
BCS1L	617	broad.mit.edu	37	2	219525825	219525825	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:219525825G>A	uc002vio.2	+	2	533	c.115G>A	c.(115-117)GGC>AGC	p.G39S	ZNF142_uc002vin.2_5'Flank|ZNF142_uc010fvt.2_5'Flank|ZNF142_uc002vim.2_5'Flank|BCS1L_uc002vip.2_Missense_Mutation_p.G39S|BCS1L_uc002viq.2_Missense_Mutation_p.G39S|BCS1L_uc010fvu.2_Missense_Mutation_p.G39S|BCS1L_uc010fvv.2_Missense_Mutation_p.G39S|BCS1L_uc002vir.2_Missense_Mutation_p.G39S|BCS1L_uc002vis.2_Missense_Mutation_p.G39S	NM_004328	NP_004319	Q9Y276	BCS1_HUMAN	BCS1-like	39	Mitochondrial matrix (Potential).				mitochondrial respiratory chain complex I assembly|mitochondrial respiratory chain complex III assembly|mitochondrial respiratory chain complex IV assembly	integral to membrane|mitochondrial respiratory chain complex III	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Renal(207;0.0474)		Epithelial(149;7.12e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGTCCAACTGGGCCTGGTGGC	0.597000													27	39					0	0	0.004656	0	0
SPEG	10290	broad.mit.edu	37	2	220309693	220309693	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:220309693C>T	uc010fwg.2	+	3	625	c.625C>T	c.(625-627)CCG>TCG	p.P209S	SPEG_uc002vlm.2_RNA|SPEG_uc010fwh.1_5'UTR|SPEG_uc002vln.1_5'UTR	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	209					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CCGCCGCCTCCCGGGCAGCCC	0.716000													6	7					0	0	0.001168	0	0
GMPPA	29926	broad.mit.edu	37	2	220366281	220366282	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:220366281_220366282GG>AA	uc002vlr.2	+	4	290_291	c.222_223GG>AA	c.(220-225)CAGGAG>CAAAAG	p.E75K	GMPPA_uc002vls.2_Missense_Mutation_p.E75K|GMPPA_uc002vlt.2_Missense_Mutation_p.E75K|GMPPA_uc002vlu.2_Missense_Mutation_p.E75K|GMPPA_uc002vlv.2_Missense_Mutation_p.E75K|GMPPA_uc002vlw.2_RNA|GMPPA_uc002vlx.2_Missense_Mutation_p.E75K	NM_013335	NP_037467	Q96IJ6	GMPPA_HUMAN	GDP-mannose pyrophosphorylase A	75					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity				0		Renal(207;0.0183)		Epithelial(149;3.82e-10)|all cancers(144;6.25e-08)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00807)|READ - Rectum adenocarcinoma(5;0.148)		CCGCCCAGCAGGAGTTTAACCT	0.545000													36	46					0	0	0.004672	0	0
TM4SF20	79853	broad.mit.edu	37	2	228228518	228228518	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:228228518C>T	uc002vpb.2	-	4	650	c.612G>A	c.(610-612)CTG>CTA	p.L204L		NM_024795	NP_079071	Q53R12	T4S20_HUMAN	transmembrane 4 L six family member 20	204	Helical; (Potential).					integral to membrane|plasma membrane					0		Renal(207;0.025)|all_lung(227;0.123)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;3.8e-11)|all cancers(144;2.57e-08)|Lung(261;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0115)		TGAGCCCAAACAGGACCTCCA	0.403000													25	44					0	0	0.005443	0	0
KIF1A	547	broad.mit.edu	37	2	241722494	241722495	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:241722494_241722495GG>AA	uc002vzy.2	-	9	976_977	c.830_831CC>TT	c.(829-831)ACC>ATT	p.T277I	KIF1A_uc010fzk.2_Missense_Mutation_p.T277I|KIF1A_uc002vzz.1_Missense_Mutation_p.T277I	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	277	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CCTTGCCCAGGGTGGTCAGCGA	0.653000													12	44					0	0	0.004672	0	0
NSFL1C	55968	broad.mit.edu	37	20	1424412	1424412	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr20:1424412G>A	uc002wfc.2	-	9	2043	c.1095C>T	c.(1093-1095)ATC>ATT	p.I365I	NSFL1C_uc002wfd.2_Silent_p.I254I|NSFL1C_uc002wfe.2_Silent_p.I334I|NSFL1C_uc002wff.2_RNA|NSFL1C_uc010gag.2_Silent_p.I131I	NM_016143	NP_057227	Q9UNZ2	NSF1C_HUMAN	p47 protein isoform a	365	UBX.					chromosome|Golgi stack|nucleus	lipid binding|protein binding				0						ACCGCTGCACGATGACAGCAT	0.597000													12	19					0	0	0.001855	0	0
FLRT3	23767	broad.mit.edu	37	20	14307575	14307575	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr20:14307575G>A	uc002wov.1	-	3	1045	c.578C>T	c.(577-579)CCA>CTA	p.P193L	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Missense_Mutation_p.P193L	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	193	Extracellular (Potential).|LRR 6.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		TTGAAGAGATGGTGATGAAAT	0.418000													48	29					0	0	0.003214	0	0
SEC23B	10483	broad.mit.edu	37	20	18506573	18506573	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr20:18506573G>A	uc002wqz.1	+	7	1274	c.831G>A	c.(829-831)CTG>CTA	p.L277L	SEC23B_uc002wra.1_Silent_p.L277L|SEC23B_uc002wrb.1_Silent_p.L277L|SEC23B_uc010zsb.1_Silent_p.L259L|SEC23B_uc002wrc.1_Silent_p.L277L	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B	277					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						TTGGCTTGCTGGAGGTAATTT	0.433000													19	43					0	0	0.003954	0	0
ZNF337	26152	broad.mit.edu	37	20	25656980	25656980	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr20:25656980G>A	uc002wva.2	-	4	1466	c.944C>T	c.(943-945)TCA>TTA	p.S315L	uc002wuz.2_RNA|ZNF337_uc010ztg.1_Missense_Mutation_p.S283L|ZNF337_uc002wvb.2_Missense_Mutation_p.S315L|ZNF337_uc002wvc.2_Missense_Mutation_p.S315L	NM_015655	NP_056470	Q9Y3M9	ZN337_HUMAN	zinc finger protein 337	315					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTCTCCCCTGAATGCGCCTT	0.473000													34	86					0	0	0.002836	0	0
DEFB118	117285	broad.mit.edu	37	20	29960671	29960671	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr20:29960671G>A	uc002wvr.2	+	2	96	c.70G>A	c.(70-72)GAA>AAA	p.E24K		NM_054112	NP_473453	Q96PH6	DB118_HUMAN	beta-defensin 118 precursor	24					cell-matrix adhesion|defense response to bacterium|innate immune response|spermatogenesis	extracellular region				ovary(3)|pancreas(1)	4	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CTATAGTGGTGAAAAAAAATG	0.398000													10	7					0	0	0.006214	0	0
BPIL1	80341	broad.mit.edu	37	20	31600712	31600712	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr20:31600712C>T	uc002wyj.2	+	4	501	c.307C>T	c.(307-309)CGC>TGC	p.R103C		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	103						extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						CAAGGTCTTTCGGTGAGCGGA	0.562000													15	90					0	0	0.003163	0	0
PMEPA1	56937	broad.mit.edu	37	20	56227601	56227601	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr20:56227601G>A	uc002xyq.2	-	4	765	c.372C>T	c.(370-372)TTC>TTT	p.F124F	PMEPA1_uc002xyr.2_Silent_p.F74F|PMEPA1_uc002xys.2_Silent_p.F89F|PMEPA1_uc002xyt.2_Silent_p.F74F	NM_020182	NP_064567	Q969W9	PMEPA_HUMAN	transmembrane prostate androgen-induced protein	124	Cytoplasmic (Potential).				androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			pancreas(1)	1						CCCGCTGGGCGAAGGGCGGCA	0.706000													6	8					0	0	0.001168	0	0
CHRNA4	1137	broad.mit.edu	37	20	61987406	61987406	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr20:61987406G>A	uc002yes.2	-	4	482	c.304C>T	c.(304-306)CCA>TCA	p.P102S	CHRNA4_uc002yet.1_Intron|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_5'UTR|CHRNA4_uc002yev.1_5'UTR|CHRNA4_uc010gkf.1_5'UTR	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	102	Extracellular (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	TAGTCAGCTGGGTCCCAGCGC	0.552000													6	37					0	0	0.001168	0	0
TPTE	7179	broad.mit.edu	37	21	10933870	10933870	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr21:10933870G>A	uc002yip.1	-	17	1377	c.1009C>T	c.(1009-1011)CAC>TAC	p.H337Y	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.H319Y|TPTE_uc002yir.1_Missense_Mutation_p.H299Y|TPTE_uc010gkv.1_Missense_Mutation_p.H199Y	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	337	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CCTTTACAGTGAATCGCTACG	0.328000													36	229					0	0	0.004289	0	0
DOPEY2	9980	broad.mit.edu	37	21	37623502	37623502	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr21:37623502G>A	uc002yvg.2	+	22	5120	c.5041G>A	c.(5041-5043)GCC>ACC	p.A1681T	DOPEY2_uc011aeb.1_Missense_Mutation_p.A1630T|DOPEY2_uc002yvh.2_Missense_Mutation_p.A532T	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1681					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						CCCCTTGACGGCCCATCTTGG	0.413000													17	70					0	0	0.006122	0	0
RIMBP3	85376	broad.mit.edu	37	22	20458667	20458668	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr22:20458667_20458668CC>TT	uc002zsd.3	-	1	3119_3120	c.2634_2635GG>AA	c.(2632-2637)GAGGGG>GAAAGG	p.G879R		NM_015672	NP_056487			RIMS binding protein 3												0	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			TCAAGCTCCCCCTCATAGAAGC	0.594000													4	11					0	0	0.004672	0	0
TMEM211	255349	broad.mit.edu	37	22	25334156	25334156	+	Silent	SNP	C	T	T	rs138723870		TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr22:25334156C>T	uc003abk.1	-	2	112	c.87G>A	c.(85-87)AGG>AGA	p.R29R		NM_001001663	NP_001001663	Q6ICI0	TM211_HUMAN	transmembrane protein 211	100						integral to membrane					0						CACTGCTTCTCCTTGGGCACA	0.512000													22	46					0	0	0.003330	0	0
GAL3ST1	9514	broad.mit.edu	37	22	30952022	30952022	+	Missense_Mutation	SNP	G	A	A	rs148732637		TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr22:30952022G>A	uc003aig.1	-	4	330	c.190C>T	c.(190-192)CGG>TGG	p.R64W	GAL3ST1_uc003aih.1_Missense_Mutation_p.R64W|GAL3ST1_uc003aii.1_Missense_Mutation_p.R64W|GAL3ST1_uc010gvz.1_Missense_Mutation_p.R64W	NM_004861	NP_004852	Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	64	Lumenal (Potential).				protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity				0						CCGTTGGCCCGGATCACTGCC	0.677000													18	27					0	0	0.006320	0	0
INPP5J	27124	broad.mit.edu	37	22	31522677	31522677	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr22:31522677G>A	uc003aju.3	+	4	1556	c.1464G>A	c.(1462-1464)ATG>ATA	p.M488I	INPP5J_uc010gwf.2_Missense_Mutation_p.M488I|INPP5J_uc003ajv.3_Missense_Mutation_p.M121I|INPP5J_uc003ajs.3_Missense_Mutation_p.M121I|INPP5J_uc011alk.1_Missense_Mutation_p.M421I|INPP5J_uc010gwg.2_Missense_Mutation_p.M53I|INPP5J_uc003ajw.2_5'UTR|INPP5J_uc003ajt.3_Missense_Mutation_p.M120I|INPP5J_uc003ajx.2_5'Flank|INPP5J_uc003ajy.2_5'Flank|INPP5J_uc003ajz.2_5'Flank	NM_001002837	NP_001002837	Q15735	PI5PA_HUMAN	phosphatidylinositol (4,5) bisphosphate	488	Catalytic (Potential).					cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			skin(1)	1						AGCTGTTCATGGATGCGCTAG	0.607000													31	85					0	0	0.003271	0	0
SSTR3	6753	broad.mit.edu	37	22	37603295	37603295	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr22:37603295C>T	uc003ara.2	-	2	610	c.548G>A	c.(547-549)GGA>GAA	p.G183E	SSTR3_uc003arb.2_Missense_Mutation_p.G183E	NM_001051	NP_001042	P32745	SSR3_HUMAN	somatostatin receptor 3	183	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			lung(1)	1						GCGGGGCACTCCCGAGAAGAC	0.726000													5	8					0	0	0.001984	0	0
PKDREJ	10343	broad.mit.edu	37	22	46655878	46655879	+	Nonsense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr22:46655878_46655879CC>TT	uc003bhh.2	-	1	3341_3342	c.3341_3342GG>AA	c.(3340-3342)TGG>TAA	p.W1114*		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1114	Extracellular (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		AACCCTCTCTCCATTCACTCTG	0.490000													16	43					0	0	0.004672	0	0
NCAPH2	29781	broad.mit.edu	37	22	50961485	50961485	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr22:50961485C>T	uc003blr.3	+	19	1689	c.1567C>T	c.(1567-1569)CAG>TAG	p.Q523*	NCAPH2_uc003blv.2_Nonsense_Mutation_p.Q523*|NCAPH2_uc010hbb.2_Intron|NCAPH2_uc003blu.3_RNA|NCAPH2_uc003bls.3_RNA|NCAPH2_uc003blt.3_RNA|NCAPH2_uc003blw.3_RNA|NCAPH2_uc003blx.3_Nonsense_Mutation_p.Q524*|NCAPH2_uc003bly.3_RNA	NM_152299	NP_689512	Q6IBW4	CNDH2_HUMAN	kleisin beta isoform 2	523					chromosome condensation	chromosome|nucleus				ovary(1)|skin(1)	2		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		CTATGGGGACCAGCTGGTCTC	0.642000													7	17					0	0	0.001984	0	0
CNTN4	152330	broad.mit.edu	37	3	2924836	2924836	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:2924836G>C	uc003bpc.2	+	8	881	c.660G>C	c.(658-660)ATG>ATC	p.M220I	CNTN4_uc003bpb.1_Intron|CNTN4_uc003bpd.1_Missense_Mutation_p.M220I	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	220					axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		CAGGAGTGATGGGTGAATATG	0.373000													17	11					0	0	0.006122	0	0
MTMR14	64419	broad.mit.edu	37	3	9743588	9743588	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:9743588C>T	uc003brz.2	+	19	2008	c.1884C>T	c.(1882-1884)GCC>GCT	p.A628A	MTMR14_uc003bsa.2_Silent_p.A576A|MTMR14_uc003bsb.2_Silent_p.A516A|MTMR14_uc011ath.1_RNA|MTMR14_uc010hcl.2_Silent_p.A270A|MTMR14_uc003bsc.2_RNA|CPNE9_uc003bsd.2_5'Flank	NM_001077525	NP_001070993	Q8NCE2	MTMRE_HUMAN	jumpy isoform 2	628						perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(99;0.227)					CTTCCGGTGCCATCGGGGGCC	0.612000													21	59					0	0	0.004656	0	0
FGD5	152273	broad.mit.edu	37	3	14862703	14862703	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:14862703C>T	uc003bzc.2	+	1	2235	c.2125C>T	c.(2125-2127)CGG>TGG	p.R709W	FGD5_uc011avk.1_Missense_Mutation_p.R709W	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	709					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						GCTTAAGTCTCGGACTGGGAA	0.557000													14	23					0	0	0.001855	0	0
ZNF385D	79750	broad.mit.edu	37	3	21465456	21465456	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:21465456C>T	uc003cce.2	-	7	1361	c.953G>A	c.(952-954)GGG>GAG	p.G318E		NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	318						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						GACACTCACCCCCAGTGGATG	0.458000													10	51					0	0	0.006214	0	0
EOMES	8320	broad.mit.edu	37	3	27763010	27763010	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:27763010C>T	uc003cdx.2	-	1	776	c.776G>A	c.(775-777)GGG>GAG	p.G259E	EOMES_uc003cdy.3_Missense_Mutation_p.G259E|EOMES_uc010hfn.2_Missense_Mutation_p.G259E|EOMES_uc011axc.1_Intron	NM_005442	NP_005433	O95936	EOMES_HUMAN	eomesodermin	259	Gly-rich.				CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|breast(1)	4						ACCTGGAACCCCCAGGCCCCC	0.617000													6	6					0	0	0.001168	0	0
SCN10A	6336	broad.mit.edu	37	3	38763770	38763770	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:38763770G>A	uc003ciq.2	-	19	3486	c.3486C>T	c.(3484-3486)ATC>ATT	p.I1162I		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1162	III.|Helical; Name=S1 of repeat III; (Potential).				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TGCTGAGCAGGATCATGAAGA	0.537000													19	29					0	0	0.007413	0	0
ZNF621	285268	broad.mit.edu	37	3	40571737	40571737	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:40571737C>T	uc003ckm.2	+	4	405	c.189C>T	c.(187-189)CAC>CAT	p.H63H	ZNF621_uc003ckn.2_Silent_p.H63H|ZNF621_uc003cko.2_Silent_p.H28H|ZNF621_uc011aze.1_Silent_p.H55H	NM_001098414	NP_001091884	Q6ZSS3	ZN621_HUMAN	zinc finger protein 621	63	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0515)|Kidney(284;0.0648)		TGATCTCCCACCTGGAGAGAG	0.507000													15	48					0	0	0.007413	0	0
ANO10	55129	broad.mit.edu	37	3	43602729	43602729	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:43602729C>T	uc003cmv.2	-	9	1630	c.1459G>A	c.(1459-1461)GAA>AAA	p.E487K	ANO10_uc011azs.1_Missense_Mutation_p.E487K|ANO10_uc003cmw.2_Missense_Mutation_p.E421K|ANO10_uc010hil.2_Missense_Mutation_p.E297K|ANO10_uc011azt.1_Missense_Mutation_p.E376K	NM_018075	NP_060545	Q9NW15	ANO10_HUMAN	transmembrane protein 16K	487	Extracellular (Potential).				cell death	chloride channel complex	chloride channel activity			ovary(2)	2						GTTCCCATTTCTTTTTCCAGG	0.383000													25	38					0	0	0.007291	0	0
NBEAL2	23218	broad.mit.edu	37	3	47038258	47038258	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:47038258C>T	uc003cqp.2	+	17	2670	c.2491C>T	c.(2491-2493)CCC>TCC	p.P831S	NBEAL2_uc010hjm.1_Missense_Mutation_p.P392S	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	831							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		TGAGACGGCACCCTTCAAGCC	0.632000													5	14					0	0	0.003080	0	0
IP6K2	51447	broad.mit.edu	37	3	48726087	48726087	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:48726087G>A	uc003cup.2	-	6	1144	c.900C>T	c.(898-900)CGC>CGT	p.R300R	NCKIPSD_uc003cum.2_5'Flank|NCKIPSD_uc003cun.2_5'Flank|NCKIPSD_uc010hkh.1_5'Flank|IP6K2_uc003cuq.2_Silent_p.R300R	NM_001005909	NP_001005909	Q9UHH9	IP6K2_HUMAN	inositol hexaphosphate kinase 2 isoform a	300					negative regulation of cell growth|phosphatidylinositol phosphorylation|positive regulation of apoptosis|type I interferon-mediated signaling pathway	intermediate filament cytoskeleton|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity				0						GGAGTTCACGGCGCAGGTACC	0.562000													28	34					0	0	0.006320	0	0
RAD54L2	23132	broad.mit.edu	37	3	51696606	51696606	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:51696606C>T	uc011bdt.1	+	22	3699	c.3574C>T	c.(3574-3576)CGT>TGT	p.R1192C	RAD54L2_uc003dbh.2_Missense_Mutation_p.R781C|RAD54L2_uc011bdu.1_Missense_Mutation_p.R886C|RAD54L2_uc003dbj.2_Missense_Mutation_p.R518C	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2	1192						nucleus	ATP binding|DNA binding|helicase activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		CCGGGAATCCCGTCAGAGCTC	0.652000													14	27					0	0	0.001855	0	0
GNL3	26354	broad.mit.edu	37	3	52724988	52724989	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:52724988_52724989CC>TT	uc003dfd.2	+	8	855_856	c.682_683CC>TT	c.(682-684)CCA>TTA	p.P228L	GNL3_uc003dfe.2_Missense_Mutation_p.P216L|GNL3_uc003dff.2_Missense_Mutation_p.P216L|SNORD69_uc003dfh.1_5'Flank	NM_014366	NP_055181	Q9BVP2	GNL3_HUMAN	guanine nucleotide binding protein-like 3	228					regulation of cell proliferation	nucleolus	GTP binding|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;6.75e-05)|Kidney(197;0.000611)|KIRC - Kidney renal clear cell carcinoma(197;0.000773)|OV - Ovarian serous cystadenocarcinoma(275;0.048)		GAATGCTGCTCCATTCAGAAGT	0.421000													20	29					0	0	0.004672	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54930841	54930841	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:54930841G>A	uc003dhf.2	+	26	2360	c.2312G>A	c.(2311-2313)CGA>CAA	p.R771Q	CACNA2D3_uc003dhg.1_Missense_Mutation_p.R677Q|CACNA2D3_uc003dhh.1_RNA|uc003dhk.1_RNA	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	771	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		CTCTGGTACCGAAGAGCCGCT	0.522000													39	47					0	0	0.006230	0	0
ARF4	378	broad.mit.edu	37	3	57569729	57569729	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:57569729T>C	uc003dix.3	-	3	502	c.154A>G	c.(154-156)AAT>GAT	p.N52D	ARF4_uc003diy.3_RNA|ARF4_uc010hnd.2_Missense_Mutation_p.N25D|ARF4_uc003diz.3_Intron	NM_001660	NP_001651	P18085	ARF4_HUMAN	ADP-ribosylation factor 4	52					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	Golgi apparatus	GTP binding|GTPase activity			upper_aerodigestive_tract(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0449)|Kidney(284;0.0561)		GTTTCCACATTAAAACCTACA	0.333000													17	44					0	0	0.006122	0	0
PRICKLE2	166336	broad.mit.edu	37	3	64085191	64085191	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:64085191G>A	uc003dmf.2	-	8	2657	c.2071C>T	c.(2071-2073)CGA>TGA	p.R691*		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	691	Arg-rich.					cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		CGAGAGCGTCGGGAACGCCTG	0.632000													16	39					0	0	0.001523	0	0
STX19	415117	broad.mit.edu	37	3	93733335	93733335	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:93733335T>A	uc003drh.1	-	2	1036	c.779A>T	c.(778-780)TAT>TTT	p.Y260F	ARL13B_uc003drc.2_Intron|ARL13B_uc010hop.2_Intron|ARL13B_uc003drd.2_Intron|ARL13B_uc003dre.2_Intron|ARL13B_uc003drf.2_Intron|ARL13B_uc003drg.2_Intron	NM_001001850	NP_001001850	Q8N4C7	STX19_HUMAN	syntaxin 19	260	t-SNARE coiled-coil homology.				intracellular protein transport|vesicle-mediated transport	membrane	SNAP receptor activity				0						ATTGTTAACATACTCTTTTGT	0.343000													5	20					0	0	0.000602	0	0
FILIP1L	11259	broad.mit.edu	37	3	99569213	99569213	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:99569213T>C	uc003dtm.2	-	5	1770	c.1307A>G	c.(1306-1308)AAA>AGA	p.K436R	C3orf26_uc003dtk.1_Intron|C3orf26_uc003dtl.2_Intron|FILIP1L_uc003dto.2_Missense_Mutation_p.K436R|FILIP1L_uc010hpf.2_Missense_Mutation_p.K12R|FILIP1L_uc010hpg.2_Missense_Mutation_p.K196R|FILIP1L_uc003dtn.2_Missense_Mutation_p.K196R|FILIP1L_uc003dtp.1_Missense_Mutation_p.K196R	NM_182909	NP_878913	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like isoform 1	436	Potential.					cytoplasm|membrane|myosin complex|nucleus				ovary(1)	1						TTGTTTGCTTTTGTTGAAAGC	0.358000													33	45					0	0	0.003271	0	0
CLSTN2	64084	broad.mit.edu	37	3	140167423	140167423	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:140167423C>T	uc003etn.2	+	6	1040	c.850C>T	c.(850-852)CAC>TAC	p.H284Y	CLSTN2_uc003etm.2_Missense_Mutation_p.H284Y	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	284	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CCCCAGCATCCACCTGGAGAC	0.537000										HNSCC(16;0.037)			48	85					0	0	0.003610	0	0
TIPARP	25976	broad.mit.edu	37	3	156395701	156395701	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:156395701T>C	uc003fav.2	+	2	463	c.215T>C	c.(214-216)GTT>GCT	p.V72A	LOC100287227_uc011boq.1_5'Flank|TIPARP_uc003faw.2_Missense_Mutation_p.V72A	NM_015508	NP_056323	Q7Z3E1	PARPT_HUMAN	TCDD-inducible poly(ADP-ribose) polymerase	72							NAD+ ADP-ribosyltransferase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|breast(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			CTTGATGGGGTTTTTAGATCT	0.398000													35	54					0	0	0.002836	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169540625	169540625	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:169540625C>T	uc003fgb.2	+	1	916	c.916C>T	c.(916-918)CGC>TGC	p.R306C		NM_001080460	NP_001073929	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	306	LRR 13.										0						GGTCAACTTGCGCTTCCTGGA	0.582000													7	9					0	0	0.003080	0	0
LRRC31	79782	broad.mit.edu	37	3	169557996	169557996	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:169557996C>G	uc003fgc.1	-	9	1510	c.1433G>C	c.(1432-1434)CGG>CCG	p.R478P	LRRC31_uc010hwp.1_Missense_Mutation_p.R422P	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	478										ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			TTTGAGGAACCGCACGTTTTG	0.473000													22	37					0	0	0.003954	0	0
TNFSF10	8743	broad.mit.edu	37	3	172224494	172224494	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:172224494T>C	uc003fid.2	-	5	729	c.634A>G	c.(634-636)AAA>GAA	p.K212E	TNFSF10_uc003fie.2_3'UTR	NM_003810	NP_003801	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily,	212	Extracellular (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			skin(4)|lung(1)	5	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CTTGTGTATTTGTAAATATAT	0.328000													31	38					0	0	0.001786	0	0
BCL6	604	broad.mit.edu	37	3	187449569	187449569	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:187449569G>A	uc003frp.3	-	4	768	c.311C>T	c.(310-312)GCT>GTT	p.A104V	BCL6_uc011bsf.1_Missense_Mutation_p.A104V|BCL6_uc010hza.2_Missense_Mutation_p.A2V|BCL6_uc003frq.1_Missense_Mutation_p.A104V	NM_001130845	NP_001124317	P41182	BCL6_HUMAN	B-cell lymphoma 6 protein isoform 1	104					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|lung(2)|central_nervous_system(1)	5	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		GGCCATCACAGCCATGATGTT	0.527000			T|Mis	IG loci|ZNFN1A1|LCP1|PIM1|TFRC|MHC2TA|NACA|HSPCB|HSPCA|HIST1H4I|IL21R| POU2AF1|ARHH|EIF4A2|SFRS3	NHL|CLL								29	37					0	0	0.002836	0	0
LPP	4026	broad.mit.edu	37	3	188327358	188327358	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:188327358G>A	uc003frs.1	+	6	1085	c.839G>A	c.(838-840)GGA>GAA	p.G280E	LPP_uc011bsg.1_Intron|LPP_uc011bsi.1_Missense_Mutation_p.G280E|LPP_uc003frt.2_Missense_Mutation_p.G280E|LPP_uc011bsj.1_Missense_Mutation_p.G117E	NM_005578	NP_005569	Q93052	LPP_HUMAN	LIM domain containing preferred translocation	280	Pro-rich.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	soft_tissue(134)|bone(27)|lung(2)|ovary(1)|breast(1)	165	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		CCACCACCAGGACTTCAGCCG	0.577000			T	HMGA2|MLL|C12orf9	lipoma|leukemia								6	62					0	0	0.001168	0	0
ZNF732	654254	broad.mit.edu	37	4	266152	266152	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:266152C>T	uc011buu.1	-	3	505	c.491G>A	c.(490-492)GGA>GAA	p.G164E	ZNF732_uc010ibb.1_Intron	NM_001137608	NP_001131080	B4DXR9	ZN732_HUMAN	zinc finger protein 732	165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTGTTTCTCTCCAGTATGTCT	0.358000													3	6					0	0	0.004672	0	0
TMEM175	84286	broad.mit.edu	37	4	941538	941538	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:941538C>T	uc003gbq.2	+	2	109	c.11C>T	c.(10-12)CCC>CTC	p.P4L	TMEM175_uc010ibl.1_Missense_Mutation_p.P4L|TMEM175_uc003gbp.1_5'UTR|TMEM175_uc003gbr.2_5'UTR|TMEM175_uc003gbu.2_Intron|TMEM175_uc003gbs.2_5'UTR|TMEM175_uc003gbt.2_5'UTR|TMEM175_uc003gbv.2_Intron	NM_032326	NP_115702	Q9BSA9	TM175_HUMAN	transmembrane protein 175	4						integral to membrane					0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			ATGTCCCAGCCCCGGACCCCA	0.692000													9	22					0	0	0.001368	0	0
EVC2	132884	broad.mit.edu	37	4	5624458	5624458	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:5624458G>A	uc003gij.2	-	14	2361	c.2307C>T	c.(2305-2307)CCC>CCT	p.P769P	EVC2_uc011bwb.1_Silent_p.P209P|EVC2_uc003gik.2_Silent_p.P689P	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	769	Potential.					integral to membrane				large_intestine(3)|ovary(2)	5						GGAAGAGCCAGGGCACCCCAC	0.652000													17	22					0	0	0.004990	0	0
C4orf23	152992	broad.mit.edu	37	4	8469649	8469649	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:8469649C>T	uc003glg.1	+	9	1004	c.816C>T	c.(814-816)CTC>CTT	p.L272L	C4orf23_uc003glf.1_Silent_p.L260L|C4orf23_uc003glh.1_Silent_p.L109L	NM_152544	NP_689757	Q8IYL2	TRM44_HUMAN	hypothetical protein LOC152992 isoform 2	501					tRNA processing	cytoplasm	methyltransferase activity|nucleic acid binding|zinc ion binding				0						AGGTCTGTCTCGTTGGAAAAT	0.468000													5	50					0	0	0.001984	0	0
HSP90AB2P	391634	broad.mit.edu	37	4	13338177	13338177	+	RNA	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:13338177C>T	uc003gms.2	+	1		c.3141C>T				NR_003132				Homo sapiens heat shock protein 90Bb (HSP90Bb) mRNA, complete cds.											kidney(1)	1						TTGCCCAACTCATGTCTCTTA	0.418000													10	23					0	0	0.008291	0	0
HSP90AB2P	391634	broad.mit.edu	37	4	13338908	13338908	+	RNA	SNP	T	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:13338908T>G	uc003gms.2	+	1		c.3872T>G				NR_003132				Homo sapiens heat shock protein 90Bb (HSP90Bb) mRNA, complete cds.											kidney(1)	1						agaagaaaactaagaagatca	0.174000													4	13					0	0	0.000248	0	0
NSUN7	79730	broad.mit.edu	37	4	40796465	40796465	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:40796465G>A	uc003gvj.3	+	9	1749	c.1254G>A	c.(1252-1254)CAG>CAA	p.Q418Q	NSUN7_uc003gvi.3_Silent_p.Q418Q	NM_024677	NP_078953			NOL1/NOP2/Sun domain family, member 7												0						CTCAACAGCAGTATGAACAGC	0.338000													9	10					0	0	0.008291	0	0
ATP8A1	10396	broad.mit.edu	37	4	42580365	42580365	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:42580365A>T	uc003gwr.2	-	12	1272	c.1040T>A	c.(1039-1041)TTC>TAC	p.F347Y	ATP8A1_uc003gws.2_Missense_Mutation_p.F347Y|ATP8A1_uc011byz.1_Missense_Mutation_p.F347Y	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	347	Helical; (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	AAGGATGATGAAGGTCAAGAA	0.358000													24	35					0	0	0.001786	0	0
NIPAL1	152519	broad.mit.edu	37	4	48027085	48027085	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:48027085G>A	uc003gxw.2	+	2	113	c.47G>A	c.(46-48)GGA>GAA	p.G16E		NM_207330	NP_997213	Q6NVV3	NIPA3_HUMAN	NIPA-like domain containing 1	16	Extracellular (Potential).					integral to membrane					0						TTTTTTCCAGGATATGTGCTG	0.488000													28	54					0	0	0.007291	0	0
SLC4A4	8671	broad.mit.edu	37	4	72413422	72413422	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:72413422G>A	uc003hfy.2	+	20	2796	c.2679G>A	c.(2677-2679)ATG>ATA	p.M893I	SLC4A4_uc010iic.2_Missense_Mutation_p.M893I|SLC4A4_uc010iib.2_Intron|SLC4A4_uc003hfz.2_Missense_Mutation_p.M893I|SLC4A4_uc003hgc.3_Missense_Mutation_p.M849I|SLC4A4_uc010iid.2_Missense_Mutation_p.M97I	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	893	Helical; (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			CAGTCTTTATGGCTCCCATCT	0.388000													27	59					0	0	0.007291	0	0
UNC5C	8633	broad.mit.edu	37	4	96222867	96222867	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:96222867G>A	uc003htp.1	-	3	534	c.380C>T	c.(379-381)TCG>TTG	p.S127L	UNC5C_uc010ilc.1_Missense_Mutation_p.S127L|UNC5C_uc003htq.2_Missense_Mutation_p.S127L	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	127	Extracellular (Potential).|Ig-like.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TTGCTGGCGCGAAATCTCAAT	0.463000													12	19					0	0	0.001368	0	0
SFRP2	6423	broad.mit.edu	37	4	154709489	154709489	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:154709489C>T	uc003inv.1	-	1	740	c.499G>A	c.(499-501)GAA>AAA	p.E167K		NM_003013	NP_003004	Q96HF1	SFRP2_HUMAN	secreted frizzled-related protein 2 precursor	167					brain development|cardiac left ventricle morphogenesis|cell-cell signaling|dermatome development|hemopoietic stem cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|negative regulation of cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|outflow tract morphogenesis|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell adhesion mediated by integrin|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of fat cell differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of stem cell division|sclerotome development	cytoplasm|extracellular matrix|extracellular space|plasma membrane	fibronectin binding|integrin binding|PDZ domain binding|receptor agonist activity|Wnt receptor activity|Wnt-protein binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.093)	Renal(120;0.117)				GGCTTACCTTCCTCGGTGGCT	0.652000													16	23					0	0	0.004990	0	0
ACCN5	51802	broad.mit.edu	37	4	156784842	156784842	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:156784842C>T	uc003ipe.1	-	2	152	c.105G>A	c.(103-105)AAG>AAA	p.K35K		NM_017419	NP_059115	Q9NY37	ACCN5_HUMAN	amiloride-sensitive cation channel 5,	35	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0464)|Kidney(143;0.058)|COAD - Colon adenocarcinoma(41;0.141)		GGTCAAACTTCTTTCGCTCAG	0.418000													14	48					0	0	0.003163	0	0
FSTL5	56884	broad.mit.edu	37	4	162841651	162841651	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:162841651C>T	uc003iqh.2	-	4	750	c.314G>A	c.(313-315)GGA>GAA	p.G105E	FSTL5_uc003iqi.2_Missense_Mutation_p.G104E|FSTL5_uc010iqv.2_Missense_Mutation_p.G104E	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	105	Kazal-like.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		ATAGAATTCTCCGTCAGATCC	0.433000													14	21					0	0	0.001855	0	0
DNAH5	1767	broad.mit.edu	37	5	13753560	13753560	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:13753560C>T	uc003jfd.2	-	63	10696	c.10654G>A	c.(10654-10656)GCC>ACC	p.A3552T	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3552					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ATTTTCCGGGCTTTCATTTCC	0.408000									Kartagener_syndrome				33	95					0	0	0.004289	0	0
FBXL7	23194	broad.mit.edu	37	5	15936615	15936615	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:15936615C>T	uc003jfn.1	+	4	1277	c.796C>T	c.(796-798)CCC>TCC	p.P266S		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	266	LRR 4.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						TAAACTGTCACCCTTGCATGG	0.572000													13	31					0	0	0.001368	0	0
CDH9	1007	broad.mit.edu	37	5	26915843	26915843	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:26915843C>T	uc003jgs.1	-	3	587	c.418G>A	c.(418-420)GAA>AAA	p.E140K	CDH9_uc010iug.2_Missense_Mutation_p.E140K	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	140	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						GATTCCGGTTCCACCTGCCGC	0.393000													39	107					0	0	0.006999	0	0
CDH9	1007	broad.mit.edu	37	5	26916004	26916004	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:26916004C>T	uc003jgs.1	-	3	426	c.257G>A	c.(256-258)GGA>GAA	p.G86E	CDH9_uc010iug.2_Missense_Mutation_p.G86E	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	86	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TTTTAAATTTCCATCTCCTTT	0.338000													17	53					0	0	0.004990	0	0
UGT3A1	133688	broad.mit.edu	37	5	35954476	35954476	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:35954476C>T	uc003jjv.1	-	7	1557	c.1400G>A	c.(1399-1401)GGA>GAA	p.G467E	UGT3A1_uc003jjw.1_RNA	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	467	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GTGCGTCGCTCCCCCAGTCTG	0.607000													24	14					0	0	0.003330	0	0
DAB2	1601	broad.mit.edu	37	5	39383123	39383123	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:39383123G>A	uc003jlx.2	-	10	1469	c.938C>T	c.(937-939)TCT>TTT	p.S313F	DAB2_uc003jlw.2_Missense_Mutation_p.S292F	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	313					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			AGATTTGAGAGAATCAAACGA	0.463000													28	95					0	0	0.008361	0	0
IL31RA	133396	broad.mit.edu	37	5	55206402	55206402	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:55206402C>T	uc003jql.2	+	12	1609	c.1544C>T	c.(1543-1545)TCC>TTC	p.S515F	IL31RA_uc003jqm.2_Missense_Mutation_p.S483F|IL31RA_uc003jqn.2_Missense_Mutation_p.S515F|IL31RA_uc010iwa.1_Missense_Mutation_p.S478F|IL31RA_uc003jqo.2_Missense_Mutation_p.S373F	NM_139017	NP_620586	Q8NI17	IL31R_HUMAN	gp130-like monocyte receptor	483	Extracellular (Potential).|Fibronectin type-III 5.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			ovary(1)	1		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				GGCCTGGAGTCCCTGAAACGA	0.468000													28	24					0	0	0.008361	0	0
HAPLN1	1404	broad.mit.edu	37	5	82948575	82948575	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:82948575C>T	uc003kim.2	-	2	240	c.169G>A	c.(169-171)GTT>ATT	p.V57I	HAPLN1_uc003kin.2_Missense_Mutation_p.V57I	NM_001884	NP_001875	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	57	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			large_intestine(3)|ovary(1)|skin(1)	5		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		GGCAGTGTAACATTGCCACCT	0.393000													17	26					0	0	0.004990	0	0
ERAP2	64167	broad.mit.edu	37	5	96225001	96225001	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:96225001C>T	uc003kmq.2	+	5	1672	c.962C>T	c.(961-963)TCC>TTC	p.S321F	uc003kmo.1_Intron|ERAP2_uc003kmt.2_Missense_Mutation_p.S321F|ERAP2_uc003kmr.2_RNA|ERAP2_uc003kms.2_Missense_Mutation_p.S270F|ERAP2_uc003kmu.2_RNA	NM_022350	NP_071745	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	321	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		TATCCACTCTCCAAACTGGGT	0.353000													20	46					0	0	0.001882	0	0
DMXL1	1657	broad.mit.edu	37	5	118513857	118513857	+	Silent	SNP	A	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:118513857A>G	uc003ksd.2	+	28	7234	c.7053A>G	c.(7051-7053)CTA>CTG	p.L2351L	DMXL1_uc010jcl.1_Silent_p.L2351L	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2351										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		CCCATCCTCTAAATGAGAAAA	0.418000													18	55					0	0	0.006122	0	0
TRPC7	57113	broad.mit.edu	37	5	135692901	135692902	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:135692901_135692902CC>TT	uc003lbn.1	-	1	174_175	c.171_172GG>AA	c.(169-174)GTGGTC>GTAATC	p.V58I	TRPC7_uc010jef.1_Missense_Mutation_p.V50I|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Missense_Mutation_p.V50I|TRPC7_uc010jei.1_Missense_Mutation_p.V50I|TRPC7_uc010jej.1_5'UTR	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	59	Cytoplasmic (Potential).|ANK 1.				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ATTTTCCGGACCACCGGGATGT	0.599000													25	73					0	0	0.004672	0	0
KDM3B	51780	broad.mit.edu	37	5	137761262	137761262	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:137761262A>T	uc003lcy.1	+	17	4602	c.4402A>T	c.(4402-4404)ATC>TTC	p.I1468F	KDM3B_uc010jew.1_Missense_Mutation_p.I1124F|KDM3B_uc011cys.1_Missense_Mutation_p.I500F	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	1468					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						TGGTTTCGAGATCATATGCAG	0.408000													9	39					0	0	0.006214	0	0
PCDHA1	56147	broad.mit.edu	37	5	140166314	140166314	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:140166314C>T	uc003lhb.2	+	1	439	c.439C>T	c.(439-441)CTC>TTC	p.L147F	PCDHA1_uc003lha.2_Missense_Mutation_p.L147F|PCDHA1_uc003lgz.2_Missense_Mutation_p.L147F	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	147	Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAATCTAGACTCCTGAATTC	0.448000													14	65					0	0	0.004990	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229320	140229320	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:140229320G>A	uc003lhu.2	+	1	1964	c.1240G>A	c.(1240-1242)GAC>AAC	p.D414N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.D414N	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	414	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGAGCTCTGGACCGCGAGAG	0.642000													14	69					0	0	0.004007	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262124	140262124	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:140262124G>A	uc003lif.2	+	1	271	c.271G>A	c.(271-273)GAC>AAC	p.D91N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.D91N|PCDHA13_uc003lid.2_Missense_Mutation_p.D91N	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	91	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTCGGATCGACCGCGAGGA	0.592000													56	94					0	0	0.003610	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262587	140262588	+	Missense_Mutation	DNP	CC	TA	TA			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:140262587_140262588CC>TA	uc003lif.2	+	1	734_735	c.734_735CC>TA	c.(733-735)TCC>TTA	p.S245L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.S245L|PCDHA13_uc003lid.2_Missense_Mutation_p.S245L	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	245	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTTACCAATCCGTTTATAAAG	0.455000													5	39					0	0	0.004672	0	0
PCDHB3	56132	broad.mit.edu	37	5	140480591	140480591	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:140480591G>A	uc003lio.2	+	1	358	c.358G>A	c.(358-360)GAG>AAG	p.E120K	uc003lin.2_Intron	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	120	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGTTACAAACGAGCTCCGTAT	0.418000													30	35					0	0	0.006320	0	0
PCDHB10	56126	broad.mit.edu	37	5	140572753	140572753	+	Silent	SNP	T	C	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:140572753T>C	uc003lix.2	+	1	802	c.628T>C	c.(628-630)TTA>CTA	p.L210L		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	210	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAGCTCAGCTTAACCCTCAC	0.507000													44	53					0	0	0.002222	0	0
PCDHGA7	56108	broad.mit.edu	37	5	140764776	140764776	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:140764776C>T	uc003lka.1	+	1	2310	c.2310C>T	c.(2308-2310)TTC>TTT	p.F770F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGB4_uc003lkc.1_5'Flank|PCDHGA7_uc003ljz.1_Silent_p.F770F|PCDHGB4_uc011dav.1_5'Flank	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	770	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCTGATCTTCCCCCAGCCCA	0.512000													38	38					0	0	0.003610	0	0
SH3TC2	79628	broad.mit.edu	37	5	148388436	148388436	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:148388436G>A	uc003lpu.2	-	15	3608	c.3456C>T	c.(3454-3456)GCC>GCT	p.A1152A	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc010jgw.2_Silent_p.A796A|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_Silent_p.A699A|SH3TC2_uc010jgx.2_Silent_p.A1145A	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	1152	TPR 6.						binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAGCCTGGCGGCCAGGGTGG	0.463000													25	69					0	0	0.003954	0	0
TNIP1	10318	broad.mit.edu	37	5	150411944	150411944	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:150411944G>A	uc003ltf.2	-	17	2369	c.1780C>T	c.(1780-1782)CCG>TCG	p.P594S	TNIP1_uc011dcn.1_Missense_Mutation_p.P112S|TNIP1_uc010jhl.2_RNA|TNIP1_uc010jhm.2_Missense_Mutation_p.P530S|TNIP1_uc010jhn.2_Intron|TNIP1_uc011dco.1_Silent_p.S599S|TNIP1_uc003lth.2_RNA|TNIP1_uc003lti.2_Missense_Mutation_p.P594S|TNIP1_uc003ltg.2_Missense_Mutation_p.P541S|TNIP1_uc003ltj.2_Missense_Mutation_p.P594S|TNIP1_uc010jho.1_RNA|TNIP1_uc010jhq.1_Intron|TNIP1_uc010jhp.1_Missense_Mutation_p.P477S|TNIP1_uc010jhr.1_Missense_Mutation_p.P594S|TNIP1_uc003ltk.2_Missense_Mutation_p.P594S	NM_006058	NP_006049	Q15025	TNIP1_HUMAN	TNFAIP3 interacting protein 1	594	Pro-rich.				defense response|glycoprotein biosynthetic process|negative regulation of viral genome replication|translation	cytoplasm|nucleus	protein binding			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.0911)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTGTATTCCGGCTGCGACAAA	0.343000													13	8					0	0	0.001855	0	0
DOK3	79930	broad.mit.edu	37	5	176932020	176932020	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:176932020C>T	uc003mhk.2	-	4	637	c.632G>A	c.(631-633)TGG>TAG	p.W211*	DOK3_uc003mhh.3_Nonsense_Mutation_p.W41*|DOK3_uc003mhi.3_Nonsense_Mutation_p.W155*|DOK3_uc003mhj.3_Nonsense_Mutation_p.W53*|DOK3_uc003mhl.2_Nonsense_Mutation_p.W155*	NM_024872	NP_079148	Q7L591	DOK3_HUMAN	docking protein 3 isoform 1	211						cytoplasm|plasma membrane	insulin receptor binding				0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			ACCTTCCTGCCAGGAGGAGTA	0.627000													13	68					0	0	0.003163	0	0
BTNL8	79908	broad.mit.edu	37	5	180335686	180335686	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:180335686C>T	uc003mmp.2	+	2	384	c.150C>T	c.(148-150)GCC>GCT	p.A50A	BTNL8_uc003mmq.2_Silent_p.A50A|BTNL8_uc011dhg.1_Intron|BTNL8_uc010jll.2_Silent_p.A50A|BTNL8_uc010jlm.2_Intron|BTNL8_uc011dhh.1_5'Flank	NM_001040462	NP_001035552	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8 isoform 2 precursor	50	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane				upper_aerodigestive_tract(1)|skin(1)	2	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATGCAGAGGCCATGGAAGTGC	0.577000													24	83					0	0	0.002780	0	0
F13A1	2162	broad.mit.edu	37	6	6145907	6145907	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:6145907A>G	uc003mwv.2	-	15	2267	c.2144T>C	c.(2143-2145)CTG>CCG	p.L715P	F13A1_uc011dib.1_3'UTR	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	715					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	CACATGTCTCAGGGAGTCACT	0.557000													20	55					0	0	0.001523	0	0
DSP	1832	broad.mit.edu	37	6	7576533	7576533	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:7576533G>A	uc003mxp.1	+	19	2916	c.2637G>A	c.(2635-2637)TGG>TGA	p.W879*	DSP_uc003mxq.1_Nonsense_Mutation_p.W879*	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	879	Globular 1.|Spectrin 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CCAGGTTATGGGACCTGGAGA	0.289000													17	39					0	0	0.007413	0	0
HIVEP1	3096	broad.mit.edu	37	6	12161705	12161705	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:12161705G>A	uc003nac.2	+	8	6700	c.6521G>A	c.(6520-6522)GGA>GAA	p.G2174E	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	2174					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GAGCGATCTGGATATGATCTT	0.408000													51	47					0	0	0.003610	0	0
CDKAL1	54901	broad.mit.edu	37	6	21201483	21201483	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:21201483G>A	uc003ndc.1	+	15	1700	c.1526G>A	c.(1525-1527)GGA>GAA	p.G509E	CDKAL1_uc003ndd.1_Missense_Mutation_p.G509E|CDKAL1_uc003nde.1_Missense_Mutation_p.G418E|CDKAL1_uc003ndf.1_Intron|CDKAL1_uc003ndg.2_RNA	NM_017774	NP_060244	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein	509					RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			ovary(2)	2	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			CTAGCAAAGGGAGAAGTCTCG	0.468000													64	166					0	0	0.003610	0	0
SCAND3	114821	broad.mit.edu	37	6	28542960	28542960	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:28542960G>A	uc003nlo.2	-	3	2140	c.1522C>T	c.(1522-1524)CAG>TAG	p.Q508*		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	508	Integrase catalytic.				DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGATAGGGCTGATTTTGGGAC	0.423000													33	68					0	0	0.002836	0	0
MAS1L	116511	broad.mit.edu	37	6	29454838	29454838	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:29454838C>T	uc011dlq.1	-	1	842	c.842G>A	c.(841-843)AGC>AAC	p.S281N		NM_052967	NP_443199	P35410	MAS1L_HUMAN	MAS1 oncogene-like	281	Helical; Name=6; (Potential).					cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			ovary(7)|lung(2)	9						GGGTGCCACGCTCAGGGGTAG	0.498000													7	33					0	0	0.003080	0	0
LTA	4049	broad.mit.edu	37	6	31541257	31541257	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:31541257C>T	uc011dnu.1	+	4	618	c.405C>T	c.(403-405)GTC>GTT	p.V135V	LTA_uc003nue.1_Silent_p.V135V|LTA_uc003nuf.2_Intron|LTA_uc003nuh.2_Intron|LTA_uc003nug.2_Intron|LTA_uc010jsr.2_Intron|TNF_uc003nui.2_5'Flank	NM_001159740	NP_001153212	P01374	TNFB_HUMAN	lymphotoxin alpha precursor	135					cell-cell signaling|induction of apoptosis|signal transduction	extracellular space|membrane	cytokine activity|tumor necrosis factor receptor binding				0					Etanercept(DB00005)	CCCATGAGGTCCAGCTCTTCT	0.592000													17	106					0	0	0.004990	0	0
SKIV2L	6499	broad.mit.edu	37	6	31936654	31936654	+	Nonsense_Mutation	SNP	C	T	T	rs138923214		TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:31936654C>T	uc003nyn.1	+	26	3576	c.3187C>T	c.(3187-3189)CGA>TGA	p.R1063*	SKIV2L_uc011dou.1_Nonsense_Mutation_p.R905*|SKIV2L_uc011dov.1_Nonsense_Mutation_p.R870*|STK19_uc003nyt.2_5'Flank|STK19_uc011dow.1_5'Flank|STK19_uc011dox.1_5'Flank|STK19_uc003nyv.2_5'Flank|STK19_uc003nyw.2_5'Flank	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	1063						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						GCAGGTGCTCCGAACCCTGGG	0.607000													29	352					0	0	0.001786	0	0
NOTCH4	4855	broad.mit.edu	37	6	32170339	32170339	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:32170339G>A	uc003obb.2	-	21	3408	c.3269C>T	c.(3268-3270)TCC>TTC	p.S1090F	NOTCH4_uc003oba.2_5'UTR|NOTCH4_uc011dpu.1_Intron|NOTCH4_uc011dpv.1_Intron	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1090	EGF-like 28.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GAAGCCGCAGGAAGGGGCCCT	0.612000													101	107					0	0	0.003610	0	0
HLA-DQA1	3117	broad.mit.edu	37	6	32609191	32609191	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:32609191G>A	uc003obr.2	+	2	240	c.187G>A	c.(187-189)GAG>AAG	p.E63K	HLA-DQA1_uc003obs.2_RNA|HLA-DQA1_uc003obt.1_Missense_Mutation_p.E63K|HLA-DQA1_uc003obu.2_5'Flank	NM_002122	NP_002113	P01909	DQA1_HUMAN	major histocompatibility complex, class II, DQ	63	Alpha-1.|Extracellular (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0						CGTGGACCTGGAGAGGAAGGA	0.517000													10	51					0	0	0.006214	0	0
BTBD9	114781	broad.mit.edu	37	6	38560556	38560556	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:38560556G>A	uc003ooa.3	-	5	1186	c.610C>T	c.(610-612)CTA>TTA	p.L204L	BTBD9_uc003ony.3_Silent_p.L136L|BTBD9_uc010jwv.2_Silent_p.L136L|BTBD9_uc010jww.2_RNA|BTBD9_uc010jwx.2_Silent_p.L204L	NM_052893	NP_443125	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9 isoform a	204	BACK.				cell adhesion						0						AATAAGGCTAGGAAAATATCT	0.383000													13	19					0	0	0.001855	0	0
FBXO9	26268	broad.mit.edu	37	6	52943611	52943611	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:52943611C>T	uc003pbo.2	+	5	403	c.352C>T	c.(352-354)CGT>TGT	p.R118C	FBXO9_uc003pbk.2_Missense_Mutation_p.R74C|FBXO9_uc003pbl.2_Missense_Mutation_p.R108C|FBXO9_uc003pbm.2_5'UTR|FBXO9_uc003pbn.2_5'UTR	NM_012347	NP_036479	Q9UK97	FBX9_HUMAN	F-box only protein 9 isoform 1	118	TPR.					ubiquitin ligase complex	ubiquitin-protein ligase activity			pancreas(1)	1	Lung NSC(77;0.103)					CAAGTTTTATCGTAGGGCTAT	0.368000													17	35					0	0	0.008871	0	0
LGSN	51557	broad.mit.edu	37	6	63990433	63990433	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:63990433C>T	uc003peh.2	-	4	1057	c.1023G>A	c.(1021-1023)GGG>GGA	p.G341G	LGSN_uc003pei.2_Missense_Mutation_p.G201E	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	341					glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	ACCATTTTTTCCCAGTGATCG	0.488000													22	18					0	0	0.002299	0	0
KCNQ5	56479	broad.mit.edu	37	6	73787061	73787061	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:73787061C>T	uc003pgk.2	+	4	980	c.633C>T	c.(631-633)ATC>ATT	p.I211I	KCNQ5_uc003pgj.3_Silent_p.I211I|KCNQ5_uc011dyh.1_Silent_p.I211I|KCNQ5_uc011dyi.1_Silent_p.I211I|KCNQ5_uc010kat.2_Silent_p.I211I|KCNQ5_uc011dyj.1_Silent_p.I211I|KCNQ5_uc011dyk.1_5'UTR	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	211	Helical; Name=Segment S3; (Potential).				protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		TTGTTCTTATCGCTTCAATAG	0.408000													15	12					0	0	0.006122	0	0
KCNQ5	56479	broad.mit.edu	37	6	73879492	73879492	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:73879492G>A	uc003pgk.2	+	11	1839	c.1492G>A	c.(1492-1494)GAT>AAT	p.D498N	KCNQ5_uc011dyh.1_Missense_Mutation_p.D517N|KCNQ5_uc011dyi.1_Missense_Mutation_p.D508N|KCNQ5_uc010kat.2_Missense_Mutation_p.D489N|KCNQ5_uc011dyj.1_Intron|KCNQ5_uc011dyk.1_Missense_Mutation_p.D248N	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	498					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		TGGCACTGATGATGTATATGA	0.423000													14	11					0	0	0.003163	0	0
FYN	2534	broad.mit.edu	37	6	112017611	112017612	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:112017611_112017612CC>TT	uc003pvj.2	-	9	1250_1251	c.910_911GG>AA	c.(910-912)GGC>AAC	p.G304N	FYN_uc003pvi.2_Missense_Mutation_p.G249N|FYN_uc003pvk.2_Missense_Mutation_p.G304N|FYN_uc003pvh.2_Missense_Mutation_p.G301N|FYN_uc010kdy.1_Intron	NM_002037	NP_002028	P06241	FYN_HUMAN	protein-tyrosine kinase fyn isoform a	304	Protein kinase.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|central_nervous_system(1)|skin(1)	7		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	GGACATTGTGCCTGGTTTAAGA	0.455000													12	12					0	0	0.004672	0	0
RFX6	222546	broad.mit.edu	37	6	117245850	117245850	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:117245850G>A	uc003pxm.2	+	15	1637	c.1574G>A	c.(1573-1575)CGA>CAA	p.R525Q		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	525					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						CATTTGATTCGAATGCTTCTC	0.383000													22	16					0	0	0.001882	0	0
INTS1	26173	broad.mit.edu	37	7	1517449	1517449	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:1517449G>A	uc003skn.2	-	34	4855	c.4754C>T	c.(4753-4755)TCC>TTC	p.S1585F	INTS1_uc003skm.1_5'Flank	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1585					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CAGCAGCAGGGAGCTCACCAC	0.687000													24	17					0	0	0.004656	0	0
FTSJ2	29960	broad.mit.edu	37	7	2279183	2279183	+	Silent	SNP	G	A	A	rs145102163	by1000genomes	TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:2279183G>A	uc003slm.2	-	2	197	c.168C>T	c.(166-168)AGC>AGT	p.S56S	FTSJ2_uc003slk.2_5'UTR|FTSJ2_uc003sll.2_5'UTR|FTSJ2_uc003sln.2_RNA|FTSJ2_uc003slo.2_5'UTR|NUDT1_uc003slp.1_5'Flank|NUDT1_uc003slq.1_5'Flank|NUDT1_uc003slr.1_5'Flank|NUDT1_uc003sls.1_5'Flank|NUDT1_uc003slt.1_5'Flank	NM_013393	NP_037525	Q9UI43	RRMJ2_HUMAN	FtsJ homolog 2	56		S-adenosyl-L-methionine.			cell proliferation	mitochondrion|nucleolus	nucleic acid binding|rRNA (uridine-2'-O-)-methyltransferase activity			ovary(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.7e-14)		GCTTGAAGGCGCTTCGACACC	0.622000													23	34					0	0	0.003954	0	0
SDK1	221935	broad.mit.edu	37	7	4152926	4152926	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:4152926G>A	uc003smx.2	+	24	3579	c.3440G>A	c.(3439-3441)CGA>CAA	p.R1147Q	SDK1_uc010kso.2_Missense_Mutation_p.R423Q	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1147	Fibronectin type-III 5.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TTTAGATTTCGAATGAAGCAA	0.537000													138	131					0	0	0.003610	0	0
WIPI2	26100	broad.mit.edu	37	7	5256236	5256236	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:5256236A>G	uc003snv.2	+	5	640	c.424A>G	c.(424-426)ATT>GTT	p.I142V	WIPI2_uc003snw.2_Missense_Mutation_p.I142V|WIPI2_uc003snx.2_Missense_Mutation_p.I124V|WIPI2_uc003sny.2_Missense_Mutation_p.I124V|WIPI2_uc010ksv.2_5'UTR|WIPI2_uc003snz.2_Missense_Mutation_p.I83V|WIPI2_uc003soa.2_Missense_Mutation_p.I83V	NM_015610	NP_056425	Q9Y4P8	WIPI2_HUMAN	WD repeat domain, phosphoinositide interacting 2	142					autophagic vacuole assembly	cytosol|PAS complex|pre-autophagosomal structure membrane	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			ovary(2)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0925)|OV - Ovarian serous cystadenocarcinoma(56;2.59e-14)		CATCCACAACATTCGGGACAT	0.517000													30	27					0	0	0.004289	0	0
NPSR1	387129	broad.mit.edu	37	7	34698136	34698136	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:34698136G>A	uc003teg.1	+	1	240	c.112G>A	c.(112-114)GGA>AGA	p.G38R	AAA1_uc010kwo.1_Intron|AAA1_uc010kwp.1_Intron|AAA1_uc003tdz.2_Intron|AAA1_uc010kwq.1_Intron|AAA1_uc003teb.1_Intron|AAA1_uc011kaq.1_Intron|NPSR1_uc003teh.1_Missense_Mutation_p.G38R|NPSR1_uc010kwt.1_5'UTR|NPSR1_uc010kwu.1_5'UTR|NPSR1_uc010kwv.1_Missense_Mutation_p.G38R|NPSR1_uc003tei.1_Missense_Mutation_p.G38R|NPSR1_uc010kww.1_Missense_Mutation_p.G38R|NPSR1_uc011kar.1_Missense_Mutation_p.G38R	NM_207172	NP_997055	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	38	Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	AGTGGTGGAAGGAAAGGAATG	0.483000													27	39					0	0	0.004656	0	0
GCK	2645	broad.mit.edu	37	7	44189363	44189363	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:44189363G>A	uc003tkl.2	-	6	1145	c.675C>T	c.(673-675)ATC>ATT	p.I225I	GCK_uc003tkj.1_Silent_p.I224I|GCK_uc003tkk.1_Silent_p.I226I	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	225					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						CCTTACCCACGATCATGCCGA	0.567000													150	167					0	0	0.003610	0	0
HGF	3082	broad.mit.edu	37	7	81381519	81381519	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:81381519C>G	uc003uhl.2	-	5	707	c.542G>C	c.(541-543)CGA>CCA	p.R181P	HGF_uc003uhm.2_Missense_Mutation_p.R176P|HGF_uc003uhn.1_Missense_Mutation_p.R181P|HGF_uc003uho.1_Missense_Mutation_p.R176P|HGF_uc003uhp.2_Missense_Mutation_p.R181P	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	181	Kringle 1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						TTCTTCCCCTCGAGGATTTCG	0.433000													16	20					0	0	0.004990	0	0
SAMD9	54809	broad.mit.edu	37	7	92730924	92730924	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:92730924C>T	uc003umf.2	-	3	4743	c.4487G>A	c.(4486-4488)GGA>GAA	p.G1496E	SAMD9_uc003umg.2_Missense_Mutation_p.G1496E	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1496						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			GTCAATTTTTCCTTTGTGAAC	0.378000													14	21					0	0	0.002450	0	0
AP4M1	9179	broad.mit.edu	37	7	99704431	99704431	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:99704431C>T	uc003utb.3	+	15	1496	c.1288C>T	c.(1288-1290)CCA>TCA	p.P430S	AP4M1_uc010lgl.1_Missense_Mutation_p.P405S|AP4M1_uc003utc.3_Missense_Mutation_p.P437S|AP4M1_uc010lgm.2_Missense_Mutation_p.P302S|AP4M1_uc003utd.2_Missense_Mutation_p.P430S|AP4M1_uc011kjh.1_Missense_Mutation_p.P382S|AP4M1_uc003ute.3_Missense_Mutation_p.P205S|AP4M1_uc003utf.3_Missense_Mutation_p.P302S	NM_004722	NP_004713	O00189	AP4M1_HUMAN	adaptor-related protein complex 4, mu 1 subunit	430	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|coated pit|Golgi trans cisterna	transporter activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGCCTTCAGGCCATGCGGCAA	0.647000													5	31					0	0	0.001168	0	0
Unknown	0	broad.mit.edu	37	7	100552100	100552100	+	RNA	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:100552100C>T	uc003uxk.1	+	1		c.1351C>T			uc003uxl.1_Missense_Mutation_p.P184L					Homo sapiens MUC3B mRNA for intestinal mucin, partial cds.																		ACAGGCTTTCCTAGTCTCTCT	0.453000													5	225					0	0	0.003330	0	0
LAMB4	22798	broad.mit.edu	37	7	107756451	107756451	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:107756451C>T	uc010ljo.1	-	3	274	c.190G>A	c.(190-192)GAG>AAG	p.E64K	LAMB4_uc003vey.2_Missense_Mutation_p.E64K	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	64	Laminin N-terminal.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						CAACCCACCTCCAGGTAACTG	0.478000													26	23					0	0	0.003954	0	0
CFTR	1080	broad.mit.edu	37	7	117199600	117199600	+	Missense_Mutation	SNP	C	T	T	rs121909017		TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:117199600C>T	uc003vjd.2	+	11	1607	c.1475C>T	c.(1474-1476)TCT>TTT	p.S492F	CFTR_uc011knq.1_5'UTR|CFTR_uc003vje.1_RNA	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	492	Cytoplasmic (Potential).|ABC transporter 1.		S -> F (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TCATTCTGTTCTCAGTTTTCC	0.383000									Cystic_Fibrosis				30	26					0	0	0.002445	0	0
CPA4	51200	broad.mit.edu	37	7	129944388	129944388	+	Missense_Mutation	SNP	C	G	G	rs141042847		TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:129944388C>G	uc003vpr.2	+	5	502	c.455C>G	c.(454-456)TCG>TGG	p.S152W	CPA4_uc011kpd.1_Missense_Mutation_p.S119W|CPA4_uc011kpe.1_Missense_Mutation_p.S48W	NM_016352	NP_057436	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4 preproprotein	152					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					ATTGGACATTCGTTTGAAAAC	0.527000													17	54					0	0	0.008871	0	0
DENND2A	27147	broad.mit.edu	37	7	140301597	140301597	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:140301597G>A	uc010lnj.2	-	1	746	c.601C>T	c.(601-603)CTT>TTT	p.L201F	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.L201F|DENND2A_uc003vvw.2_Missense_Mutation_p.L201F|DENND2A_uc003vvx.2_Missense_Mutation_p.L201F	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	201										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					TTCTCAGGAAGGGTGGACCCT	0.637000													8	57					0	0	0.004482	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				15	24					0	0	0.004990	0	0
OR9A2	135924	broad.mit.edu	37	7	142723902	142723902	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:142723902C>T	uc003wcc.1	-	1	318	c.318G>A	c.(316-318)ATG>ATA	p.M106I		NM_001001658	NP_001001658	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A,	106					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.059)					ATGCAAACTCCATGGTCCCAC	0.458000													16	18					0	0	0.003163	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147183076	147183076	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:147183076G>A	uc003weu.1	+	11	2236	c.1720G>A	c.(1720-1722)GAC>AAC	p.D574N		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	574	EGF-like 1.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GCAAACATGGGACAGCTTCAA	0.433000										HNSCC(39;0.1)			17	71					0	0	0.007413	0	0
ZNF786	136051	broad.mit.edu	37	7	148769064	148769065	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:148769064_148769065GG>AA	uc003wfh.2	-	4	936_937	c.799_800CC>TT	c.(799-801)CCC>TTC	p.P267F	ZNF786_uc011kuk.1_Missense_Mutation_p.P230F|ZNF786_uc003wfi.2_Missense_Mutation_p.P181F	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	267					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			GTTCCGGAAGGGGCCCCTCCCC	0.678000													7	11					0	0	0.004672	0	0
ADAM7	8756	broad.mit.edu	37	8	24323234	24323234	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:24323234C>T	uc003xeb.2	+	5	448	c.335C>T	c.(334-336)TCC>TTC	p.S112F	ADAM7_uc003xea.1_Missense_Mutation_p.S112F	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	112	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		TACCAAGGATCCATAGTACAC	0.289000													7	21					0	0	0.003080	0	0
WRN	7486	broad.mit.edu	37	8	30948414	30948414	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:30948414C>T	uc003xio.3	+	15	2573	c.1785C>T	c.(1783-1785)ATC>ATT	p.I595I	WRN_uc010lvk.2_Silent_p.I62I	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	595	Helicase ATP-binding.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		GCCTTGTTATCTCTCCCCTTA	0.343000			Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				12	52					0	0	0.003163	0	0
RP1	6101	broad.mit.edu	37	8	55539965	55539965	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:55539965G>A	uc003xsd.1	+	4	3671	c.3523G>A	c.(3523-3525)GAA>AAA	p.E1175K	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1175					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TATCACAGAGGAAGCTGATGA	0.408000													18	20					0	0	0.006122	0	0
CHD7	55636	broad.mit.edu	37	8	61732609	61732609	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:61732609G>A	uc003xue.2	+	9	3134	c.2657G>A	c.(2656-2658)CGG>CAG	p.R886Q	CHD7_uc003xuf.2_5'UTR	NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	886	Chromo 2.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GAGGTTGACCGGATAATGGAC	0.383000													4	12					0	0	0.001984	0	0
CSPP1	79848	broad.mit.edu	37	8	68007696	68007696	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:68007696C>T	uc003xxi.2	+	8	815	c.784C>T	c.(784-786)CGA>TGA	p.R262*	CSPP1_uc003xxg.1_Nonsense_Mutation_p.R254*|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Nonsense_Mutation_p.R227*|CSPP1_uc003xxk.2_5'UTR	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	262	Potential.					centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			GGACAGATACCGACAACTAGA	0.368000													20	33					0	0	0.001523	0	0
PREX2	80243	broad.mit.edu	37	8	68999972	68999972	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:68999972C>T	uc003xxv.1	+	19	2068	c.2041C>T	c.(2041-2043)CCA>TCA	p.P681S	PREX2_uc003xxu.1_Missense_Mutation_p.P681S|PREX2_uc011lez.1_Missense_Mutation_p.P616S	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	681	PDZ 2.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						AGTGAAAATTCCAGATTCAGC	0.423000													17	50					0	0	0.001523	0	0
ZFHX4	79776	broad.mit.edu	37	8	77776234	77776234	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:77776234C>T	uc003yav.2	+	11	10536	c.10149C>T	c.(10147-10149)TTC>TTT	p.F3383F		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3379						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCTGTTATTTCGGTCAGCCTT	0.438000										HNSCC(33;0.089)			4	14					0	0	0.000248	0	0
TMEM67	91147	broad.mit.edu	37	8	94809558	94809558	+	Splice_Site	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:94809558G>A	uc011lgk.1	+	20	2032	c.1961_splice	c.e20-1	p.G654_splice	TMEM67_uc010maw.2_Splice_Site_p.G360_splice|TMEM67_uc003yga.3_Splice_Site_p.G573_splice|TMEM67_uc011lgl.1_Splice_Site_p.G53_splice	NM_153704	NP_714915	Q5HYA8	MKS3_HUMAN	meckelin isoform 1						cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			ovary(2)	2	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			TTCCTGACCAGGTGAGGGTGG	0.353000													14	40					0	0	0.008871	0	0
CDH17	1015	broad.mit.edu	37	8	95164197	95164197	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:95164197T>G	uc003ygh.2	-	13	1820	c.1695A>C	c.(1693-1695)CAA>CAC	p.Q565H	CDH17_uc011lgo.1_Missense_Mutation_p.Q351H|CDH17_uc011lgp.1_Missense_Mutation_p.Q565H	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	565	Extracellular (Potential).|Cadherin 5.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			GTTGGGAAAATTGAGGTGCTT	0.438000													4	33					0	0	0.000602	0	0
KIAA1429	25962	broad.mit.edu	37	8	95538606	95538606	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:95538606C>T	uc003ygo.1	-	8	1879	c.1866G>A	c.(1864-1866)GGG>GGA	p.G622G	KIAA1429_uc003ygp.2_Silent_p.G622G|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	622					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TTTCTATTTCCCCTTCACTTA	0.383000													14	47					0	0	0.002450	0	0
ZNF572	137209	broad.mit.edu	37	8	125989827	125989827	+	Silent	SNP	T	C	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:125989827T>C	uc003yrr.2	+	3	1472	c.1317T>C	c.(1315-1317)CCT>CCC	p.P439P		NM_152412	NP_689625	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	439					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			GAGAGAAACCTTATAAATGTC	0.438000										HNSCC(60;0.17)			29	43					0	0	0.007291	0	0
EPPK1	83481	broad.mit.edu	37	8	144940534	144940534	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:144940534G>A	uc003zaa.1	-	2	14911	c.14898C>T	c.(14896-14898)ATC>ATT	p.I4966I		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	4966	Plectin 62.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCTTCTCCTGGATCTCGCCGC	0.701000													7	75					0	0	0.003080	0	0
IFNA16	3449	broad.mit.edu	37	9	21217173	21217173	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:21217173C>T	uc003zor.1	-	1	138	c.132G>A	c.(130-132)ATG>ATA	p.M44I	IFNA14_uc003zoo.1_Intron	NM_002173	NP_002164	P05015	IFN16_HUMAN	interferon, alpha 16 precursor	44					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			skin(1)	1				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		AGATTCTTCCCATTTGTGCCA	0.507000													49	25					0	0	0.003610	0	0
PIGO	84720	broad.mit.edu	37	9	35092421	35092421	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:35092421G>A	uc003zwd.2	-	7	1859	c.1463C>T	c.(1462-1464)GCC>GTC	p.A488V	PIGO_uc003zwc.1_3'UTR|PIGO_uc003zwe.2_Intron|PIGO_uc003zwf.2_Intron|PIGO_uc003zwg.1_Missense_Mutation_p.A51V	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	488	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CAGGCCCCAGGCCACAGGTGT	0.562000													18	24					0	0	0.008871	0	0
PGM5	5239	broad.mit.edu	37	9	71098840	71098840	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:71098840C>T	uc004agr.2	+	9	1584	c.1355C>T	c.(1354-1356)GCC>GTC	p.A452V		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	452					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						GACCTGGAGGCCCTGGTCACA	0.507000													20	18					0	0	0.001882	0	0
TRPM3	80036	broad.mit.edu	37	9	73164507	73164507	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:73164507C>T	uc004aid.2	-	24	3866	c.3622G>A	c.(3622-3624)GAT>AAT	p.D1208N	TRPM3_uc004ahu.2_Missense_Mutation_p.D1050N|TRPM3_uc004ahv.2_Missense_Mutation_p.D1010N|TRPM3_uc004ahw.2_Missense_Mutation_p.D1080N|TRPM3_uc004ahx.2_Missense_Mutation_p.D1067N|TRPM3_uc004ahy.2_Missense_Mutation_p.D1070N|TRPM3_uc004ahz.2_Missense_Mutation_p.D1057N|TRPM3_uc004aia.2_Missense_Mutation_p.D1055N|TRPM3_uc004aib.2_Missense_Mutation_p.D1045N|TRPM3_uc004aic.2_Missense_Mutation_p.D1208N	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1233	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						TTGAACCGATCATCCTTTTCT	0.423000													8	47					0	0	0.003080	0	0
NCBP1	4686	broad.mit.edu	37	9	100431132	100431132	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:100431132G>A	uc004axq.2	+	21	2480	c.2021G>A	c.(2020-2022)AGT>AAT	p.S674N		NM_002486	NP_002477	Q09161	NCBP1_HUMAN	nuclear cap binding protein subunit 1, 80kDa	674	Potential.			S -> G (in Ref. 3; BAG35665).	gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA cleavage|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of mRNA 3'-end processing|positive regulation of viral transcription|regulation of translational initiation|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm|ribonucleoprotein complex	protein binding|RNA cap binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.158)				CTATAGCGAAGTGATGATGAC	0.418000													6	19					0	0	0.001168	0	0
OR13C4	138804	broad.mit.edu	37	9	107288604	107288604	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:107288604T>A	uc011lvn.1	-	1	887	c.887A>T	c.(886-888)TAT>TTT	p.Y296F		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	296	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCTCAAGCTATAGATTATGGG	0.398000													21	25					0	0	0.008871	0	0
KLF4	9314	broad.mit.edu	37	9	110249863	110249864	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:110249863_110249864GG>AA	uc004bdh.2	-	3	1405_1406	c.784_785CC>TT	c.(784-786)CCG>TTG	p.P262L	KLF4_uc004bdf.1_Missense_Mutation_p.P221L|KLF4_uc004bdg.2_Missense_Mutation_p.P271L	NM_004235	NP_004226	O43474	KLF4_HUMAN	Kruppel-like factor 4 (gut)	271	Pro-rich.				fat cell differentiation|mesodermal cell fate determination|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|stem cell maintenance|transcription from RNA polymerase II promoter	nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(2)|lung(1)	3						GCACGTGCGCGGCGGCCCGCCG	0.703000													5	2					0	0	0.004672	0	0
ACTL7B	10880	broad.mit.edu	37	9	111617367	111617367	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:111617367C>T	uc004bdi.2	-	1	909	c.844G>A	c.(844-846)GAG>AAG	p.E282K		NM_006686	NP_006677	Q9Y614	ACL7B_HUMAN	actin-like 7B	282						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			pancreas(1)	1						TCCGGGAGCTCGTAGTCCACG	0.632000													16	22					0	0	0.004007	0	0
PAPPA	5069	broad.mit.edu	37	9	118974139	118974139	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:118974139G>A	uc004bjn.2	+	4	2227	c.1846G>A	c.(1846-1848)GGG>AGG	p.G616R	PAPPA_uc011lxp.1_Intron|PAPPA_uc011lxq.1_Intron	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	616					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						TGGTGACCCAGGGCCAGGAAA	0.532000													33	126					0	0	0.002445	0	0
ZBTB6	10773	broad.mit.edu	37	9	125673909	125673909	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:125673909G>A	uc004bnh.2	-	2	532	c.443C>T	c.(442-444)CCT>CTT	p.P148L		NM_006626	NP_006617	Q15916	ZBTB6_HUMAN	zinc finger and BTB domain containing 6	148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTAACATCAGGATCAGAAGA	0.338000													12	25					0	0	0.000978	0	0
MAPKAP1	79109	broad.mit.edu	37	9	128347848	128347848	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:128347848C>T	uc004bpv.2	-	5	990	c.657G>A	c.(655-657)CGG>CGA	p.R219R	MAPKAP1_uc011lzt.1_Silent_p.R22R|MAPKAP1_uc010mwz.2_RNA|MAPKAP1_uc011lzu.1_Silent_p.R22R|MAPKAP1_uc011lzv.1_Silent_p.R22R|MAPKAP1_uc004bpw.2_Silent_p.R27R|MAPKAP1_uc004bpx.2_Silent_p.R27R|MAPKAP1_uc004bpy.2_Silent_p.R219R|MAPKAP1_uc004bpz.2_Silent_p.R219R|MAPKAP1_uc010mxa.2_RNA|MAPKAP1_uc010mxb.1_Silent_p.R22R|MAPKAP1_uc004bqa.2_Silent_p.R219R|MAPKAP1_uc010mxc.1_Silent_p.R91R	NM_001006617	NP_001006618	Q9BPZ7	SIN1_HUMAN	mitogen-activated protein kinase associated	219					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|response to stress|T cell costimulation	cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	Ras GTPase binding			ovary(2)|lung(2)	4						GCTTCGGCTCCCGTCCTTCGC	0.542000													10	38					0	0	0.001368	0	0
GTF3C5	9328	broad.mit.edu	37	9	135927462	135927463	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:135927462_135927463CC>TT	uc004cci.3	+	5	1121_1122	c.784_785CC>TT	c.(784-786)CCC>TTC	p.P262F	GTF3C5_uc010mzz.2_Missense_Mutation_p.P137F|GTF3C5_uc004ccj.3_Missense_Mutation_p.P262F	NM_012087	NP_036219	Q9Y5Q8	TF3C5_HUMAN	general transcription factor IIIC, polypeptide 5	262						transcription factor TFIIIC complex	DNA binding|protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;4.01e-06)|Epithelial(140;4e-05)		TGACATCCGTCCCATCTGGTCC	0.564000													15	20					0	0	0.004672	0	0
ABCA2	20	broad.mit.edu	37	9	139910781	139910781	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:139910781G>A	uc011mem.1	-	20	3211	c.3063C>T	c.(3061-3063)TCC>TCT	p.S1021S	ABCA2_uc011mel.1_Silent_p.S1022S|ABCA2_uc004ckl.1_Silent_p.S952S|ABCA2_uc004ckm.1_Silent_p.S1052S|ABCA2_uc004ckn.1_RNA	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	1021	ABC transporter 1.				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GGCCCAAGAAGGAGACCACCT	0.597000													6	17					0	0	0.001984	0	0
COBRA1	25920	broad.mit.edu	37	9	140161467	140161468	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:140161467_140161468GG>AA	uc004cmm.3	+	9	1370_1371	c.1167_1168GG>AA	c.(1165-1170)GTGGAT>GTAAAT	p.D390N		NM_015456	NP_056271	Q8WX92	NELFB_HUMAN	cofactor of BRCA1	390					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleoplasm	protein binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.137)	OV - Ovarian serous cystadenocarcinoma(145;9.42e-05)|Epithelial(140;0.000766)		CTTTCAATGTGGATCAGAAACT	0.554000													5	32					0	0	0.004672	0	0
TUBBP5	643224	broad.mit.edu	37	9	141071340	141071340	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:141071340G>A	uc004com.2	+	4	1004	c.743G>A	c.(742-744)CGC>CAC	p.R248H	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						TTCCAGGGTCGCATGCCCATG	0.542000													5	71					0	0	0.003080	0	0
IL3RA	3563	broad.mit.edu	37	X	1460719	1460719	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:1460719G>A	uc004cps.2	+	2	410	c.61G>A	c.(61-63)GAA>AAA	p.E21K	IL3RA_uc011mhd.1_Missense_Mutation_p.E21K	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	21	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	GCAAACGAAGGAAGGTAAGAA	0.567000													65	77					0	0	0.003610	0	0
ARSF	416	broad.mit.edu	37	X	3030306	3030306	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:3030306C>T	uc004cre.1	+	11	1703	c.1482C>T	c.(1480-1482)TTC>TTT	p.F494F	ARSF_uc004crf.1_Silent_p.F494F	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	494						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCAGATGTTTCGGAGAACAGG	0.547000													41	108					0	0	0.003610	0	0
MXRA5	25878	broad.mit.edu	37	X	3239265	3239265	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:3239265C>T	uc004crg.3	-	5	4618	c.4461G>A	c.(4459-4461)CGG>CGA	p.R1487R		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1487						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCTCCTTCATCCGGGCAGCAG	0.498000													12	54					0	0	0.000978	0	0
BMX	660	broad.mit.edu	37	X	15560224	15560224	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:15560224G>A	uc004cww.2	+	15	1702	c.1514G>A	c.(1513-1515)GGA>GAA	p.G505E	BMX_uc004cwx.3_Missense_Mutation_p.G505E|BMX_uc004cwy.3_Missense_Mutation_p.G505E	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	505	Protein kinase.				cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					AGGAGTCACGGAAAAGGACTT	0.438000													98	127					0	0	0.003610	0	0
XK	7504	broad.mit.edu	37	X	37545385	37545385	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:37545385C>T	uc004ddq.2	+	1	253	c.171C>T	c.(169-171)TTC>TTT	p.F57F		NM_021083	NP_066569	P51811	XK_HUMAN	membrane transport protein XK	57	Helical; (Potential).				amino acid transport	integral to membrane	protein binding|transporter activity				0		all_lung(315;0.175)				CGCTTCTCTTCGTACACCGCG	0.657000													11	12					0	0	0.000978	0	0
DGAT2L6	347516	broad.mit.edu	37	X	69419695	69419696	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:69419695_69419696CC>TT	uc004dxx.1	+	3	327_328	c.230_231CC>TT	c.(229-231)ACC>ATT	p.T77I		NM_198512	NP_940914	Q6ZPD8	DG2L6_HUMAN	diacylglycerol O-acyltransferase 2-like 6	77					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(1)	1						CGAAACTGGACCCTATGGAAGT	0.554000													4	20					0	0	0.004672	0	0
CDX4	1046	broad.mit.edu	37	X	72667312	72667312	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:72667312C>T	uc011mqk.1	+	1	223	c.223C>T	c.(223-225)CCC>TCC	p.P75S		NM_005193	NP_005184	O14627	CDX4_HUMAN	caudal type homeobox 4	75						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(35;0.156)					CTGGGGCTCACCCTACAGTCC	0.602000													21	28					0	0	0.001882	0	0
ATP7A	538	broad.mit.edu	37	X	77243950	77243950	+	Silent	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:77243950G>A	uc004ecx.3	+	3	493	c.333G>A	c.(331-333)AAG>AAA	p.K111K	ATP7A_uc004ecw.2_Silent_p.K111K	NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	111	Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						TGAAGACCAAGGGTGTGACAG	0.438000													58	286					0	0	0.003610	0	0
CENPI	2491	broad.mit.edu	37	X	100381742	100381742	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:100381742C>T	uc004egx.2	+	8	1002	c.732C>T	c.(730-732)TTC>TTT	p.F244F	CENPI_uc011mrg.1_Silent_p.F244F|CENPI_uc004egy.2_Silent_p.F244F	NM_006733	NP_006724	Q92674	CENPI_HUMAN	centromere protein I	244					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			skin(1)	1						TGTATAAGTTCTTTGCTCCTG	0.353000													95	210					0	0	0.003610	0	0
DRP2	1821	broad.mit.edu	37	X	100486727	100486727	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:100486727C>T	uc004egz.2	+	3	460	c.91C>T	c.(91-93)CTC>TTC	p.L31F	DRP2_uc011mrh.1_Intron	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	31					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						TAGCAGCAGCCTCCGAAGCAC	0.537000													24	64					0	0	0.004656	0	0
ZMAT1	84460	broad.mit.edu	37	X	101139525	101139525	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:101139525T>G	uc004eim.2	-	2	3859	c.361A>C	c.(361-363)AAG>CAG	p.K121Q	ZMAT1_uc011mrl.1_Missense_Mutation_p.K292Q|ZMAT1_uc004ein.2_Missense_Mutation_p.K121Q|ZMAT1_uc011mrm.1_Missense_Mutation_p.K121Q	NM_032441	NP_115817	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 3	121						nucleus	zinc ion binding			ovary(1)	1						GGTAACTGCTTTTCCATTGCT	0.403000													26	104					0	0	0.005443	0	0
CXorf57	55086	broad.mit.edu	37	X	105881014	105881014	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:105881014A>G	uc004emi.3	+	8	1584	c.1433A>G	c.(1432-1434)TAT>TGT	p.Y478C	CXorf57_uc004emj.3_Missense_Mutation_p.Y478C|CXorf57_uc004emh.2_Missense_Mutation_p.Y478C	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	478										ovary(1)|lung(1)|breast(1)	3						CCGTATACGTATGATGCCAAG	0.378000													11	39					0	0	0.001855	0	0
COL4A5	1287	broad.mit.edu	37	X	107824250	107824250	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:107824250G>A	uc004enz.1	+	16	1131	c.929G>A	c.(928-930)GGA>GAA	p.G310E	COL4A5_uc011mso.1_Missense_Mutation_p.G310E|COL4A5_uc004eob.1_5'Flank	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	310	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						GGCCAACCAGGAATTCCTGTA	0.388000									Alport_syndrome_with_Diffuse_Leiomyomatosis				23	41					0	0	0.003954	0	0
ZCCHC16	340595	broad.mit.edu	37	X	111697959	111697959	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:111697959G>A	uc004epo.1	+	3	444	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_001004308	NP_001004308	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	1							nucleic acid binding|zinc ion binding			ovary(1)	1						GAGACATAATGGAGAAGTGCA	0.468000													30	60					0	0	0.006230	0	0
NKAP	79576	broad.mit.edu	37	X	119070327	119070327	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:119070327C>T	uc004esh.2	-	4	773	c.606G>A	c.(604-606)TCG>TCA	p.S202S	NKAP_uc004esg.2_Silent_p.S89S	NM_024528	NP_078804	Q8N5F7	NKAP_HUMAN	NFKB activating protein	202	Necessary for interaction with CIR1.|Lys-rich.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			ovary(2)	2						GTTTTCTTTTCGATGATTTTT	0.348000													27	45					0	0	0.007291	0	0
GRIA3	2892	broad.mit.edu	37	X	122387391	122387391	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:122387391G>A	uc004etq.3	+	4	799	c.506G>A	c.(505-507)CGA>CAA	p.R169Q	GRIA3_uc004etr.3_Missense_Mutation_p.R169Q|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_Missense_Mutation_p.R153Q	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	169	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	GACACAGAACGAGGTAAGAAG	0.433000													12	35					0	0	0.004990	0	0
ODZ1	10178	broad.mit.edu	37	X	123657238	123657238	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:123657238C>A	uc004euj.2	-	17	3073	c.3009G>T	c.(3007-3009)AGG>AGT	p.R1003S	ODZ1_uc011muj.1_Missense_Mutation_p.R1002S|ODZ1_uc010nqy.2_Missense_Mutation_p.R1003S	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1003	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CAATAGTTCCCCTCTCTGGAC	0.433000													30	56					1.39806e-14	3.6342e-14	0.008361	1	0
CDR1	1038	broad.mit.edu	37	X	139866498	139866498	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:139866498C>T	uc004fbg.1	-	1	226	c.34G>A	c.(34-36)GAC>AAC	p.D12N	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	12	23 X 6 AA approximate repeats.|2.										0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				AAAGGTACGTCTTCCAGAAAA	0.413000													67	146					0	0	0.003610	0	0
CXorf40B	541578	broad.mit.edu	37	X	149100870	149100870	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:149100870C>T	uc004fdy.2	-	5	885	c.369G>A	c.(367-369)GTG>GTA	p.V123V	CXorf40B_uc011mxs.1_RNA	NM_001013845	NP_001013867	Q96DE9	CX04B_HUMAN	hypothetical protein LOC541578	123											0	Acute lymphoblastic leukemia(192;6.56e-05)					GGTTTGAAATCACAGTCAGGT	0.502000													37	103					0	0	0.002522	0	0
MAGEA5	4104	broad.mit.edu	37	X	151283696	151283696	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:151283696C>T	uc004ffj.2	-	3	522	c.317G>A	c.(316-318)CGA>CAA	p.R106Q		NM_021049	NP_066387	P43359	MAGA5_HUMAN	melanoma antigen family A, 5	106	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					GAGTGCTGCTCGGAACACAGA	0.512000													38	61					0	0	0.006230	0	0
EMD	2010	broad.mit.edu	37	X	153608118	153608118	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:153608118C>T	uc004fkl.2	+	2	399	c.151C>T	c.(151-153)CCC>TCC	p.P51S		NM_000117	NP_000108	P50402	EMD_HUMAN	emerin	51	Interaction with F-actin (Probable).				cellular response to growth factor stimulus|muscle contraction|muscle organ development|negative regulation of catenin import into nucleus|negative regulation of fibroblast proliferation|positive regulation of protein export from nucleus|regulation of canonical Wnt receptor signaling pathway	endoplasmic reticulum|integral to membrane|microtubule|nuclear inner membrane|nuclear outer membrane	actin binding|beta-tubulin binding				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCTCTCGCCCCCCAGCTCGTC	0.672000													12	34					0	0	0.000978	0	0
GAB3	139716	broad.mit.edu	37	X	153944500	153944500	+	Silent	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:153944500C>T	uc004fmj.1	-	2	225	c.177G>A	c.(175-177)GTG>GTA	p.V59V	GAB3_uc004fmk.1_Silent_p.V59V|GAB3_uc010nve.1_Silent_p.V59V|GAB3_uc004fml.1_5'UTR	NM_080612	NP_542179	Q8WWW8	GAB3_HUMAN	Gab3 protein isoform 2	59	PH.									ovary(1)	1	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TGAGGTCTATCACCCGGATGG	0.552000													36	30					0	0	0.006230	0	0
RAB39B	116442	broad.mit.edu	37	X	154490183	154490184	+	Nonsense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:154490183_154490184GG>AA	uc004fne.2	-	2	825_826	c.546_547CC>TT	c.(544-549)ATCCAG>ATTTAG	p.Q183*		NM_171998	NP_741995	Q96DA2	RB39B_HUMAN	RAB39B, member RAS oncogene family	183					protein transport|small GTPase mediated signal transduction|synapse organization|vesicle-mediated transport	Golgi apparatus|plasma membrane	GTP binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CAGCCCTCCTGGATTGTAATCT	0.460000													29	56					0	0	0.004672	0	0
SPRY3	10251	broad.mit.edu	37	X	155004375	155004375	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:155004375C>T	uc004fnq.1	+	2	1296	c.842C>T	c.(841-843)CCC>CTC	p.P281L	SPRY3_uc010nvl.1_Missense_Mutation_p.P182L	NM_005840	NP_005831	O43610	SPY3_HUMAN	sprouty homolog 3	281					multicellular organismal development|regulation of signal transduction	cytoplasm|membrane					0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GCACCCTTCCCCAAGGCCCAG	0.542000													28	42					0	0	0.008361	0	0
SPRY3	10251	broad.mit.edu	37	X	155004376	155004376	+	Silent	SNP	C	A	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:155004376C>A	uc004fnq.1	+	2	1297	c.843C>A	c.(841-843)CCC>CCA	p.P281P	SPRY3_uc010nvl.1_Silent_p.P182P	NM_005840	NP_005831	O43610	SPY3_HUMAN	sprouty homolog 3	281					multicellular organismal development|regulation of signal transduction	cytoplasm|membrane					0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CACCCTTCCCCAAGGCCCAGG	0.547000													28	42					3.73148e-12	9.6742e-12	0.007291	1	0
CABC1	56997	broad.mit.edu	37	1	227153415	227153431	+	Frame_Shift_Del	DEL	TTGGCCGGCTGGCCAAC	-	-	rs119468005		TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:227153415_227153431delTTGGCCGGCTGGCCAAC	uc001hqm.1	+	9	4051_4067	c.632_648delTTGGCCGGCTGGCCAAC	c.(631-648)ATTGGCCGGCTGGCCAACfs	p.I211fs	CABC1_uc001hqn.1_Frame_Shift_Del_p.I211fs|CABC1_uc009xeq.1_Frame_Shift_Del_p.I159fs|CABC1_uc010pvq.1_Intron|CABC1_uc010pvr.1_5'UTR	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	211_216					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)				GTGACGAGGATTGGCCGGCTGGCCAACTTCGGAGGTA	0.645													8	24	---	---	---	---					
PTPN5	84867	broad.mit.edu	37	11	18762237	18762237	+	Frame_Shift_Del	DEL	C	-	-			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:18762237delC	uc001mpd.2	-	8	1259	c.828delG	c.(826-828)GAGfs	p.E276fs	PTPN5_uc001mpb.2_Frame_Shift_Del_p.E244fs|PTPN5_uc001mpc.2_Frame_Shift_Del_p.E276fs|PTPN5_uc001mpe.2_Frame_Shift_Del_p.E244fs|PTPN5_uc010rdj.1_Frame_Shift_Del_p.E220fs|PTPN5_uc001mpf.2_Frame_Shift_Del_p.E252fs|PTPN5_uc010rdk.1_Frame_Shift_Del_p.E221fs	NM_006906	NP_008837	P54829	PTN5_HUMAN	protein-tyrosine-phosphatase non-receptor 5	276						integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(2)	2						TGAGCAGGTACTCGCGGGCGG	0.597													19	18	---	---	---	---					
SLC22A6	9356	broad.mit.edu	37	11	62744845	62744845	+	Frame_Shift_Del	DEL	C	-	-			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:62744845delC	uc001nwk.2	-	9	1683	c.1376delG	c.(1375-1377)GGAfs	p.G459fs	SLC22A6_uc001nwl.2_Intron|SLC22A6_uc001nwj.2_Frame_Shift_Del_p.G459fs|SLC22A6_uc001nwm.2_Intron	NM_004790	NP_004781	Q4U2R8	S22A6_HUMAN	solute carrier family 22 member 6 isoform a	459	Helical; (Potential).				alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding				0						GCTGCCCATTCCCATGCCTGT	0.607													5	5	---	---	---	---					
USP28	57646	broad.mit.edu	37	11	113673923	113673924	+	Frame_Shift_Ins	INS	-	C	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:113673923_113673924insC	uc001poh.2	-	23	2851_2852	c.2818_2819insG	c.(2818-2820)GTCfs	p.V940fs	USP28_uc001pog.2_Frame_Shift_Ins_p.V616fs|USP28_uc010rwy.1_Frame_Shift_Ins_p.V783fs|USP28_uc001poi.2_Frame_Shift_Ins_p.V263fs	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	940					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		GGATTCTTTGACCCCCCGGCGG	0.455													17	41	---	---	---	---					
ZNF287	57336	broad.mit.edu	37	17	16455883	16455885	+	In_Frame_Del	DEL	GAA	-	-			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:16455883_16455885delGAA	uc002gqi.2	-	6	2024_2026	c.1571_1573delTTC	c.(1570-1575)CTTCAG>CAG	p.L524del		NM_020653	NP_065704	Q9HBT7	ZN287_HUMAN	zinc finger protein 287	517	C2H2-type 6.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		TTTTGATGCTGAAGAAGGTGTGT	0.350													14	59	---	---	---	---					
MIR639	693224	broad.mit.edu	37	19	14640438	14640439	+	RNA	INS	-	G	G	rs35149836		TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:14640438_14640439insG	hsa-mir-639|MI0003654	+			c.84_85insG			DNAJB1_uc010xnr.1_5'Flank|TECR_uc002mza.2_5'UTR|TECR_uc002mzb.2_5'UTR|TECR_uc010xns.1_5'UTR|TECR_uc002mzc.2_5'UTR|TECR_uc002mzd.2_5'UTR																	0						CGAGCGCTGTAGGGAGCCTGTG	0.683													8	14	---	---	---	---					
RBM5	10181	broad.mit.edu	37	3	50151482	50151483	+	Frame_Shift_Ins	INS	-	G	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:50151482_50151483insG	uc003cyg.2	+	19	1865_1866	c.1717_1718insG	c.(1717-1719)AGGfs	p.R573fs	RBM5_uc011bdj.1_Frame_Shift_Ins_p.R517fs|RBM5_uc011bdk.1_Frame_Shift_Ins_p.R401fs|RBM5_uc003cyh.2_Frame_Shift_Ins_p.R30fs	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5	573	Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GGAAGAAGAAAGGAGAGAATCT	0.426													10	52	---	---	---	---					
MUC13	56667	broad.mit.edu	37	3	124646549	124646552	+	Frame_Shift_Del	DEL	AATG	-	-			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:124646549_124646552delAATG	uc003ehq.1	-	2	362_365	c.338_341delCATT	c.(337-342)TCATTAfs	p.S113fs		NM_033049	NP_149038	Q9H3R2	MUC13_HUMAN	mucin 13, epithelial transmembrane	113_114	Thr-rich.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane					0						AGAGGTAGCTAATGAATTTACATT	0.412													47	119	---	---	---	---					
EIF3H	8667	broad.mit.edu	37	8	117658804	117658824	+	In_Frame_Del	DEL	CTGGCGCTGCATATTCTCCTG	-	-			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:117658804_117658824delCTGGCGCTGCATATTCTCCTG	uc003yoa.2	-	7	873_893	c.847_867delCAGGAGAATATGCAGCGCCAG	c.(847-867)CAGGAGAATATGCAGCGCCAGdel	p.QENMQRQ283del	EIF3H_uc003yob.2_In_Frame_Del_p.QENMQRQ297del	NM_003756	NP_003747	O15372	EIF3H_HUMAN	eukaryotic translation initiation factor 3,	283_289					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(3)	3	all_cancers(13;3.98e-22)|Lung NSC(37;0.000183)|Ovarian(258;0.0172)					CTCCTCGGCTCTGGCGCTGCATATTCTCCTGCTGGCGACGC	0.520													14	126	---	---	---	---					
TAF1	6872	broad.mit.edu	37	X	70612480	70612480	+	Frame_Shift_Del	DEL	T	-	-			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:70612480delT	uc004dzu.3	+	19	2891	c.2840delT	c.(2839-2841)CTGfs	p.L947fs	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Frame_Shift_Del_p.L968fs|TAF1_uc004dzv.3_Frame_Shift_Del_p.L121fs	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	947					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				GGCAAGTGTCTGCTAGAGGTG	0.507													45	46	---	---	---	---					
