Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TNFRSF25	8718	broad.mit.edu	37	1	6521677	6521677	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:6521677G>A	uc001ane.2	-	10	1159	c.1071C>T	c.(1069-1071)CGC>CGT	p.R357R	TNFRSF25_uc001ana.2_Silent_p.R174R|TNFRSF25_uc001anb.2_RNA|TNFRSF25_uc001anc.2_RNA|TNFRSF25_uc001and.2_Silent_p.R130R|TNFRSF25_uc009vlz.2_RNA|TNFRSF25_uc001anf.2_Silent_p.R320R|TNFRSF25_uc001ang.2_Silent_p.R312R|TNFRSF25_uc001anh.2_Silent_p.R366R	NM_003790	NP_003781	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily,	357	Death.|Cytoplasmic (Potential).				apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			central_nervous_system(2)|breast(1)	3	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		TCTCTGCCTCGCGCAGCCCCA	0.701													5	25					0	0	0.001984	0	0
AADACL3	126767	broad.mit.edu	37	1	12785954	12785954	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:12785954G>A	uc009vnn.1	+	4	1277	c.1044G>A	c.(1042-1044)AAG>AAA	p.K348K	AADACL3_uc001aug.1_Silent_p.K278K	NM_001103170	NP_001096640	Q5VUY0	ADCL3_HUMAN	arylacetamide deacetylase-like 3 isoform 1	348							hydrolase activity				0	Ovarian(185;0.249)	Lung NSC(185;8.27e-05)|all_lung(284;9.47e-05)|Renal(390;0.000147)|Colorectal(325;0.000583)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		AATTTGTAAAGGGACTGTGAC	0.493													11	31					0	0	0.001368	0	0
PLEKHM2	23207	broad.mit.edu	37	1	16056311	16056311	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:16056311A>G	uc010obo.1	+	14	2322	c.2095A>G	c.(2095-2097)AAG>GAG	p.K699E		NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	699					Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		GGCTTCTTTGAAGTCAGCCAT	0.547													11	62					0	0	0.001368	0	0
MST1P2	11209	broad.mit.edu	37	1	16975268	16975268	+	RNA	SNP	T	C	C			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:16975268T>C	uc010och.1	+	8		c.1637T>C			MST1P2_uc001azk.2_RNA|MST1P2_uc001azl.3_RNA|MST1P2_uc009vox.2_RNA|MST1P2_uc001azm.3_RNA	NR_027504				Homo sapiens cDNA FLJ43241 fis, clone HEART1000010, weakly  similar to Hepatocyte growth factor-like protein precursor.												0						CCAGCCGCCATCAATCCTGGA	0.582													8	59					0	0	0.006214	0	0
HNRNPR	10236	broad.mit.edu	37	1	23637799	23637799	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:23637799T>A	uc001bgr.3	-	10	1343	c.1184A>T	c.(1183-1185)AAT>ATT	p.N395I	HNRNPR_uc001bgo.2_Missense_Mutation_p.N5I|HNRNPR_uc001bgp.3_Missense_Mutation_p.N398I|HNRNPR_uc009vqk.2_Missense_Mutation_p.N297I|HNRNPR_uc001bgs.3_Missense_Mutation_p.N294I|HNRNPR_uc010odw.1_Missense_Mutation_p.N357I|HNRNPR_uc010odx.1_Missense_Mutation_p.N235I|HNRNPR_uc009vql.2_Missense_Mutation_p.N256I	NM_005826	NP_005817	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	395	RRM 3.					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		TTCTTTGCCATTCATTTCATC	0.338													14	12					0	0	0.001855	0	0
WDTC1	23038	broad.mit.edu	37	1	27618877	27618877	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:27618877C>T	uc009vst.2	+	7	1186	c.651C>T	c.(649-651)ATC>ATT	p.I217I	WDTC1_uc001bno.2_Silent_p.I217I|WDTC1_uc001bnp.1_RNA	NM_015023	NP_055838	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	217	WD 4.						protein binding			ovary(1)|central_nervous_system(1)	2		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		TCCGCATGATCCATAACCACA	0.567													9	54					0	0	0.004482	0	0
RAB42	115273	broad.mit.edu	37	1	28920589	28920589	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:28920589C>T	uc001bqu.2	+	2	584	c.278C>T	c.(277-279)TCC>TTC	p.S93F	RAB42_uc001bqv.2_Missense_Mutation_p.S93F	NM_152304	NP_689517	Q8N4Z0	RAB42_HUMAN	RAB42, member RAS oncogene family	93					small GTPase mediated signal transduction	membrane	GTP binding				0		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00618)|all_lung(284;0.00909)|Breast(348;0.0249)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0577)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00298)|KIRC - Kidney renal clear cell carcinoma(1967;0.00948)|BRCA - Breast invasive adenocarcinoma(304;0.0213)|READ - Rectum adenocarcinoma(331;0.0649)		ATCCCCAGGTCCCCCAGCAGG	0.607													5	32					0	0	0.001168	0	0
KPNA6	23633	broad.mit.edu	37	1	32636331	32636331	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:32636331C>T	uc001bug.2	+	14	1535	c.1447C>T	c.(1447-1449)CAG>TAG	p.Q483*	KPNA6_uc001buh.2_Nonsense_Mutation_p.Q258*|KPNA6_uc010ogx.1_Nonsense_Mutation_p.Q480*|KPNA6_uc010ogy.1_Nonsense_Mutation_p.Q488*|KPNA6_uc009vtz.2_Nonsense_Mutation_p.Q378*	NM_012316	NP_036448	O60684	IMA7_HUMAN	karyopherin alpha 6	483	ARM 10; atypical.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				TGAGTTTCTCCAGAGCCACGA	0.468													10	70					0	0	0.008291	0	0
RNF19B	127544	broad.mit.edu	37	1	33402703	33402703	+	Missense_Mutation	SNP	G	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:33402703G>T	uc010oho.1	-	9	1903	c.1903C>A	c.(1903-1905)CCC>ACC	p.P635T	RNF19B_uc001bwm.3_3'UTR|RNF19B_uc010ohp.1_Missense_Mutation_p.P634T	NM_153341	NP_699172	Q6ZMZ0	RN19B_HUMAN	ring finger protein 19B isoform a	635						integral to membrane	ligase activity|protein binding|zinc ion binding				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				CTGCAGGGGGGATCCTCTTCA	0.567													28	115					3.80469e-20	6.30548e-20	0.001786	1	0
CSMD2	114784	broad.mit.edu	37	1	34046481	34046481	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:34046481G>A	uc001bxn.1	-	49	7294	c.7265C>T	c.(7264-7266)CCT>CTT	p.P2422L	CSMD2_uc001bxm.1_Missense_Mutation_p.P2420L	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2422	CUB 14.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TTTCAGCAGAGGACTCTGTCC	0.557													22	11					0	0	0.003330	0	0
CSMD2	114784	broad.mit.edu	37	1	34209041	34209041	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:34209041G>A	uc001bxn.1	-	14	1922	c.1893C>T	c.(1891-1893)TTC>TTT	p.F631F	CSMD2_uc001bxm.1_Silent_p.F671F	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	631	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGATGACCAGGAAATCAAACT	0.617													22	72					0	0	0.002780	0	0
MPL	4352	broad.mit.edu	37	1	43818334	43818334	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:43818334G>A	uc001ciw.2	+	12	1844	c.1799G>A	c.(1798-1800)GGG>GAG	p.G600E	MPL_uc009vwr.2_Missense_Mutation_p.G593E	NM_005373	NP_005364	P40238	TPOR_HUMAN	myeloproliferative leukemia virus oncogene	600	Cytoplasmic (Potential).				cell proliferation|platelet activation	integral to plasma membrane	cytokine receptor activity			haematopoietic_and_lymphoid_tissue(361)|upper_aerodigestive_tract(1)|pancreas(1)	363	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TCTTGCCTGGGGACCATGCCC	0.572			Mis		MPD	MPD	congenital amegakaryocytic thrombocytopenia						14	37					0	0	0.003163	0	0
TOE1	114034	broad.mit.edu	37	1	45807144	45807145	+	Splice_Site	DNP	GG	AA	AA			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:45807144_45807145GG>AA	uc009vxq.2	+	4	820	c.237_splice	c.e4-1	p.Q79_splice	MUTYH_uc001cnf.2_5'Flank|MUTYH_uc009vxo.2_5'Flank|MUTYH_uc001cng.2_5'Flank|MUTYH_uc001cnj.2_5'Flank|MUTYH_uc001cni.2_5'Flank|MUTYH_uc001cnh.2_5'Flank|MUTYH_uc001cno.2_5'Flank|MUTYH_uc001cnk.2_5'Flank|MUTYH_uc010oll.1_5'Flank|MUTYH_uc001cnm.2_5'Flank|MUTYH_uc001cnl.2_5'Flank|MUTYH_uc009vxp.2_5'Flank|MUTYH_uc001cnn.2_5'Flank|TOE1_uc001cnq.3_Splice_Site|TOE1_uc010olm.1_Intron|TOE1_uc010oln.1_Splice_Site_p.Q85_splice|TOE1_uc001cnr.3_Splice_Site	NM_025077	NP_079353	Q96GM8	TOE1_HUMAN	target of EGR1, member 1 (nuclear)							nuclear speck|nucleolus	nucleic acid binding|zinc ion binding			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)					CCAACCCCAAGGTGCATTGAGG	0.584													20	11					0	0	0.004672	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47583502	47583502	+	Missense_Mutation	SNP	C	T	T	rs145758676		TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:47583502C>T	uc001cqu.1	+	12	1417	c.1414C>T	c.(1414-1416)CGC>TGC	p.R472C		NM_178134	NP_835235	Q86W10	CP4Z1_HUMAN	cytochrome P450 4Z1	472	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			skin(1)	1						AACTCTGCTCCGCTTCAAGCT	0.468													37	10					0	0	0.003755	0	0
USP24	23358	broad.mit.edu	37	1	55586392	55586392	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:55586392C>T	uc001cyg.3	-	35	3905	c.3905G>A	c.(3904-3906)AGT>AAT	p.S1302N		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	1462					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						GTCTGTCTGACTAAGAGTGTA	0.468													4	0					0	0	0.000602	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94643639	94643639	+	Silent	SNP	G	C	C	rs34014249		TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:94643639G>C	uc001dqj.3	-	21	2934	c.2565C>G	c.(2563-2565)CCC>CCG	p.P855P	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dqk.2_Silent_p.P421P	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	855	Rho-GAP.				Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		GAGCAGTTGTGGGCCTTGGCC	0.443													56	16					0	0	0.003610	0	0
COL11A1	1301	broad.mit.edu	37	1	103348859	103348859	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:103348859A>G	uc001dul.2	-	64	5185	c.4867T>C	c.(4867-4869)TGG>CGG	p.W1623R	COL11A1_uc001duk.2_Missense_Mutation_p.W819R|COL11A1_uc001dum.2_Missense_Mutation_p.W1635R|COL11A1_uc001dun.2_Missense_Mutation_p.W1584R|COL11A1_uc009weh.2_Missense_Mutation_p.W1507R	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1623	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GGATCAATCCAATATTCACCT	0.323													35	8					0	0	0.004878	0	0
SNX27	81609	broad.mit.edu	37	1	151641027	151641027	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:151641027G>A	uc001eyn.1	+	7	1081	c.1065G>A	c.(1063-1065)TTG>TTA	p.L355L	SNX27_uc001eyo.2_Silent_p.L262L|SNX27_uc001eyp.2_Silent_p.L169L	NM_030918	NP_112180	Q96L92	SNX27_HUMAN	sorting nexin family member 27	355	Ras-associating.				cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			ovary(2)|central_nervous_system(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCACCTGCTTGACCATTCGAA	0.383													50	36					0	0	0.003610	0	0
DENND4B	9909	broad.mit.edu	37	1	153907303	153907303	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:153907303C>T	uc001fdd.1	-	18	3107	c.2706G>A	c.(2704-2706)CAG>CAA	p.Q902Q	uc001fdc.1_RNA	NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	902	Gln-rich.									ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			gctgctgctgctgttgctgct	0.468													7	75					0	0	0.001984	0	0
PEAR1	375033	broad.mit.edu	37	1	156873814	156873814	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:156873814G>A	uc001fqj.1	+	2	212	c.96G>A	c.(94-96)TGG>TGA	p.W32*	PEAR1_uc009wsl.1_5'Flank|PEAR1_uc001fqk.1_5'Flank	NM_001080471	NP_001073940	Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	32	EMI.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCAGCTTCTGGGAAAGGTGAG	0.592													55	41					0	0	0.003610	0	0
FCRL4	83417	broad.mit.edu	37	1	157548559	157548560	+	Splice_Site	DNP	CC	AT	AT			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:157548559_157548560CC>AT	uc001fqw.2	-	9	1496	c.1360_splice	c.e9+1	p.V454_splice	FCRL4_uc010phy.1_Intron	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor							integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				GGAATCCTCACCATCAACATAC	0.559													25	18					0	0	0.004672	0	0
FCER1A	2205	broad.mit.edu	37	1	159273949	159273949	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:159273949C>T	uc001ftq.2	+	4	407	c.308C>T	c.(307-309)CCT>CTT	p.P103L		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	103	Extracellular (Potential).|Ig-like 1.					integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	GAGAGTGAACCTGTGTACCTG	0.393													36	17					0	0	0.007835	0	0
OR10J5	127385	broad.mit.edu	37	1	159505705	159505705	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:159505705G>A	uc010piw.1	-	1	93	c.93C>T	c.(91-93)TTC>TTT	p.F31F		NM_001004469	NP_001004469	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J,	31	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_hematologic(112;0.0429)					AGACAGTTAGGAAAACCACAA	0.378													41	31					0	0	0.006999	0	0
USP21	27005	broad.mit.edu	37	1	161130921	161130921	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:161130921C>T	uc010pke.1	+	3	868	c.491C>T	c.(490-492)CCT>CTT	p.P164L	USP21_uc010pkc.1_Missense_Mutation_p.P164L|USP21_uc010pkd.1_Missense_Mutation_p.P164L|USP21_uc010pkf.1_Missense_Mutation_p.P164L	NM_001014443	NP_001014443	Q9UK80	UBP21_HUMAN	ubiquitin-specific protease 21	164					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding|NEDD8-specific protease activity|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)|prostate(1)|breast(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GGGGGCTTTCCTGGACCCCCT	0.627													32	20					0	0	0.003271	0	0
USP21	27005	broad.mit.edu	37	1	161134339	161134339	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:161134339C>T	uc010pke.1	+	11	1698	c.1321C>T	c.(1321-1323)CGG>TGG	p.R441W	USP21_uc010pkc.1_Missense_Mutation_p.R441W|USP21_uc010pkd.1_Missense_Mutation_p.R441W|USP21_uc010pkf.1_Missense_Mutation_p.R441W|PPOX_uc001fyj.2_5'Flank|PPOX_uc001fyn.2_5'Flank|PPOX_uc001fyg.2_5'Flank|PPOX_uc001fyl.2_5'Flank|PPOX_uc001fym.2_5'Flank|PPOX_uc001fyk.2_5'Flank|PPOX_uc001fyh.2_5'Flank|PPOX_uc010pkg.1_5'Flank|PPOX_uc009wuc.1_5'Flank|PPOX_uc010pkh.1_5'Flank|PPOX_uc001fyi.2_5'Flank	NM_001014443	NP_001014443	Q9UK80	UBP21_HUMAN	ubiquitin-specific protease 21	441					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding|NEDD8-specific protease activity|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)|prostate(1)|breast(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			TGACCGATGTCGGCAGAAAAC	0.408													26	13					0	0	0.006320	0	0
ANGPTL1	9068	broad.mit.edu	37	1	178821885	178821885	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:178821885C>T	uc001gma.2	-	5	1697	c.1221G>A	c.(1219-1221)GGG>GGA	p.G407G	RALGPS2_uc001gly.1_Intron|RALGPS2_uc001glz.2_Intron|RALGPS2_uc010pnb.1_Intron|ANGPTL1_uc001gmb.2_Silent_p.G407G	NM_004673	NP_004664	O95841	ANGL1_HUMAN	angiopoietin-like 1 precursor	407	Fibrinogen C-terminal.					extracellular space	receptor binding				0						TCATAGAATCCCCTGCATTTC	0.393													13	56					0	0	0.001855	0	0
ACBD6	84320	broad.mit.edu	37	1	180461443	180461443	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:180461443G>A	uc001gog.2	-	3	966	c.345C>T	c.(343-345)ATC>ATT	p.I115I		NM_032360	NP_115736	Q9BR61	ACBD6_HUMAN	acyl-coenzyme A binding domain containing 6	115	ACB.					cytoplasm|nucleus	fatty-acyl-CoA binding			ovary(1)	1						TAACTACTGCGATATATTCCT	0.358													29	12					0	0	0.002836	0	0
CACNA1E	777	broad.mit.edu	37	1	181726222	181726222	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:181726222G>A	uc001gow.2	+	30	4454	c.4289G>A	c.(4288-4290)GGG>GAG	p.G1430E	CACNA1E_uc009wxs.2_Missense_Mutation_p.G1318E|CACNA1E_uc001gox.1_Missense_Mutation_p.G656E|CACNA1E_uc009wxt.2_Missense_Mutation_p.G656E	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1430	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CAGGAGCAAGGGGATAAGATG	0.458													28	24					0	0	0.006320	0	0
RGS18	64407	broad.mit.edu	37	1	192153620	192153620	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:192153620G>A	uc001gsg.2	+	5	820	c.644G>A	c.(643-645)CGA>CAA	p.R215Q		NM_130782	NP_570138	Q9NS28	RGS18_HUMAN	regulator of G-protein signalling 18	215					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)	3						CTTAGGAGACGATCACGCTCA	0.358													8	27					0	0	0.003080	0	0
CFHR3	10878	broad.mit.edu	37	1	196749096	196749096	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:196749096C>T	uc001gtl.2	+	3	510	c.423C>T	c.(421-423)ATC>ATT	p.I141I	CFHR3_uc001gtk.2_Silent_p.I141I|CFHR3_uc010poy.1_Silent_p.I141I|CFHR1_uc001gtm.2_Intron	NM_021023	NP_066303	Q02985	FHR3_HUMAN	complement factor H-related 3 precursor	141	Sushi 2.					extracellular space					0						CCAGATGCATCCGTGTCAGTA	0.483													24	26					0	0	0.006320	0	0
ASPM	259266	broad.mit.edu	37	1	197093279	197093279	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:197093279C>T	uc001gtu.2	-	13	3608	c.3351G>A	c.(3349-3351)ATG>ATA	p.M1117I	ASPM_uc001gtv.2_Missense_Mutation_p.M1117I|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1117	CH 2.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TTACCCAATCCATCAATAACT	0.284													7	54					0	0	0.003080	0	0
CRB1	23418	broad.mit.edu	37	1	197313433	197313433	+	Silent	SNP	T	C	C			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:197313433T>C	uc001gtz.2	+	3	810	c.675T>C	c.(673-675)ATT>ATC	p.I225I	CRB1_uc010poz.1_Silent_p.I156I|CRB1_uc001gty.1_Silent_p.I225I|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Intron|CRB1_uc010ppb.1_Silent_p.I225I|CRB1_uc010ppc.1_RNA	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	225	EGF-like 6; calcium-binding (Potential).|Extracellular (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						AATTGGAAATTGACGAATGTT	0.408													41	131					0	0	0.003610	0	0
KCNH1	3756	broad.mit.edu	37	1	210970930	210970930	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:210970930C>T	uc001hib.2	-	9	2005	c.1835G>A	c.(1834-1836)GGA>GAA	p.G612E	KCNH1_uc001hic.2_Missense_Mutation_p.G585E	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	612	Cytoplasmic (Potential).|cNMP.				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		AACGCTCTCTCCTGCATGGTA	0.607													42	30					0	0	0.006999	0	0
LEFTY2	7044	broad.mit.edu	37	1	226127455	226127455	+	Splice_Site	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:226127455C>T	uc001hpt.1	-	2	577	c.497_splice	c.e2+1	p.R166_splice	LEFTY2_uc010pvk.1_Splice_Site_p.R132_splice|LEFTY2_uc009xek.1_Intron	NM_003240	NP_003231	O00292	LFTY2_HUMAN	endometrial bleeding associated factor						cell growth|multicellular organismal development|platelet activation|platelet degranulation|transforming growth factor beta receptor signaling pathway	extracellular space|platelet alpha granule lumen	cytokine activity|growth factor activity|transforming growth factor beta receptor binding				0	Breast(184;0.197)					GCGACCCCCACCTGGAGTCGA	0.781													11	10					0	0	0.008291	0	0
CHRM3	1131	broad.mit.edu	37	1	240071827	240071827	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:240071827C>T	uc001hyp.2	+	5	1855	c.1076C>T	c.(1075-1077)TCC>TTC	p.S359F		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	359	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GACATTGGCTCCGAGACGAGA	0.572													3	10					0	0	0.004672	0	0
OR2T6	254879	broad.mit.edu	37	1	248550993	248550993	+	Silent	SNP	C	T	T	rs61736237	byFrequency	TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr1:248550993C>T	uc001iei.1	+	1	84	c.84C>T	c.(82-84)TTC>TTT	p.F28F		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	28	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GATTCTTTTTCGGTGTCATTT	0.438													16	46					0	0	0.004007	0	0
NEBL	10529	broad.mit.edu	37	10	21185923	21185923	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr10:21185923C>T	uc001iqi.2	-	2	514	c.117G>A	c.(115-117)ATG>ATA	p.M39I	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	39	Nebulin 1.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						TGGCCAATTCCATGCTTAAGT	0.328													116	25					0	0	0.003610	0	0
GPR158	57512	broad.mit.edu	37	10	25886921	25886921	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr10:25886921G>A	uc001isj.2	+	11	2426	c.2366G>A	c.(2365-2367)AGG>AAG	p.R789K	GPR158_uc001isk.2_Missense_Mutation_p.R164K	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	789	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						GCCCTCATCAGGAAGAACCCC	0.547													69	10					0	0	0.003610	0	0
MYO3A	53904	broad.mit.edu	37	10	26385322	26385322	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr10:26385322T>A	uc001isn.2	+	16	1935	c.1575T>A	c.(1573-1575)AAT>AAA	p.N525K	MYO3A_uc009xko.1_Missense_Mutation_p.N525K|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.N525K	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	525	Myosin head-like.		N -> K (in an ovarian mucinous carcinoma sample; somatic mutation).		protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity	p.N525K(1)		ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						GAGAAAAAAATTTTCATATTT	0.318													15	21					0	0	0.004007	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37419246	37419246	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr10:37419246G>C	uc001iza.1	+	3	381	c.282G>C	c.(280-282)GAG>GAC	p.E94D		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	150	ANK 3.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						TTTATAGTGAGATTTTGTCAG	0.403													8	26					0	0	0.003080	0	0
BMS1	9790	broad.mit.edu	37	10	43293981	43293981	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr10:43293981A>G	uc001jaj.2	+	12	2513	c.2155A>G	c.(2155-2157)AAC>GAC	p.N719D		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	719					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						GTTTCGTGTCAACCAGCCTGA	0.463													82	16					0	0	0.003610	0	0
PGBD3	267004	broad.mit.edu	37	10	50724534	50724534	+	Silent	SNP	A	G	G			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr10:50724534A>G	uc001jht.2	-	2	882	c.627T>C	c.(625-627)CAT>CAC	p.H209H	ERCC6_uc001jhs.3_Intron|PGBD3_uc009xoe.2_Silent_p.H677H|PGBD3_uc001jhu.2_Silent_p.H677H	NM_170753	NP_736609	Q8N328	PGBD3_HUMAN	hypothetical protein LOC267004	209										pancreas(1)|breast(1)|skin(1)	3						CCAGTACATTATGCACATCTG	0.383													54	7					0	0	0.003610	0	0
GPR120	338557	broad.mit.edu	37	10	95347060	95347060	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr10:95347060C>G	uc010qnt.1	+	4	884	c.828C>G	c.(826-828)TTC>TTG	p.F276L	GPR120_uc010qnu.1_Missense_Mutation_p.F260L	NM_181745	NP_859529	Q5NUL3	O3FA1_HUMAN	G protein-coupled receptor 120	276	Cytoplasmic (Potential).				negative regulation of cytokine secretion|negative regulation of inflammatory response|regulation of glucose transport	integral to membrane|plasma membrane	fatty acid binding				0		Colorectal(252;0.122)				AGCAGGACTTCCGGCTCTTCC	0.547													96	13					0	0	0.003610	0	0
CYP2C19	1557	broad.mit.edu	37	10	96612508	96612508	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr10:96612508G>A	uc010qnz.1	+	9	1310	c.1310G>A	c.(1309-1311)GGA>GAA	p.G437E	CYP2C19_uc010qny.1_Missense_Mutation_p.G415E	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,	437					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	ATTTGTGTGGGAGAGGGCCTG	0.433													53	19					0	0	0.003610	0	0
SHOC2	8036	broad.mit.edu	37	10	112724208	112724208	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr10:112724208C>T	uc001kzl.3	+	2	441	c.92C>T	c.(91-93)TCT>TTT	p.S31F	SHOC2_uc009xxx.2_Missense_Mutation_p.S31F|SHOC2_uc010qrg.1_Intron|SHOC2_uc001kzn.2_Missense_Mutation_p.S31F	NM_007373	NP_031399	Q9UQ13	SHOC2_HUMAN	soc-2 suppressor of clear homolog	31					fibroblast growth factor receptor signaling pathway|positive regulation of Ras protein signal transduction|Ras protein signal transduction	nucleus|protein phosphatase type 1 complex	protein phosphatase binding|protein phosphatase regulator activity			ovary(1)|skin(1)	2				Epithelial(162;0.000796)|all cancers(201;0.011)|BRCA - Breast invasive adenocarcinoma(275;0.126)		GCAAAAGCCTCTGGAGGTTTT	0.438													58	14					0	0	0.003610	0	0
GPAM	57678	broad.mit.edu	37	10	113926232	113926232	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr10:113926232T>G	uc009xxy.1	-	12	1347	c.1149A>C	c.(1147-1149)AGA>AGC	p.R383S	GPAM_uc001kzp.2_Missense_Mutation_p.R383S|GPAM_uc001kzq.1_Missense_Mutation_p.R383S	NM_020918	NP_065969	Q9HCL2	GPAT1_HUMAN	mitochondrial glycerol 3-phosphate	383					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			ovary(1)|skin(1)	2				Epithelial(162;0.0306)|all cancers(201;0.123)		TAATAACACCTCTTGCTACAC	0.383													56	9					0	0	0.003610	0	0
C10orf137	26098	broad.mit.edu	37	10	127414358	127414358	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr10:127414358C>T	uc001liq.1	+	6	1036	c.743C>T	c.(742-744)CCC>CTC	p.P248L	C10orf137_uc001lin.2_Missense_Mutation_p.P248L|C10orf137_uc001lio.1_Missense_Mutation_p.P248L|C10orf137_uc001lip.1_5'UTR	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	248					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TGGCCTGCTCCCTTCGAAATG	0.478													47	5					0	0	0.003610	0	0
FAM196A	642938	broad.mit.edu	37	10	128973855	128973855	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr10:128973855C>T	uc001lju.1	-	1	846	c.805G>A	c.(805-807)GGT>AGT	p.G269S	DOCK1_uc001ljt.2_Intron|DOCK1_uc010qun.1_Intron|FAM196A_uc010quo.1_Missense_Mutation_p.G269S|FAM196A_uc001ljv.1_Missense_Mutation_p.G269S|FAM196A_uc009yap.1_Missense_Mutation_p.G269S	NM_001039762	NP_001034851	Q6ZSG2	F196A_HUMAN	hypothetical protein LOC642938	269										ovary(2)	2						TCTGACAAACCAGGCTCGGGG	0.647													7	35					0	0	0.003080	0	0
NUP98	4928	broad.mit.edu	37	11	3797137	3797138	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:3797137_3797138GG>AA	uc001lyh.2	-	5	760_761	c.469_470CC>TT	c.(469-471)CCT>TTT	p.P157F	NUP98_uc001lyi.2_Missense_Mutation_p.P157F|NUP98_uc001lyj.1_Missense_Mutation_p.P157F|NUP98_uc001lyk.1_Missense_Mutation_p.P157F|NUP98_uc010qxv.1_Missense_Mutation_p.P120F	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	157	Gly/Thr-rich.				carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		AGTCCCAGTAGGAGCAGCTGTA	0.396			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								79	59					0	0	0.004672	0	0
OR52K1	390036	broad.mit.edu	37	11	4510460	4510460	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:4510460C>T	uc001lza.1	+	1	330	c.330C>T	c.(328-330)TCC>TCT	p.S110S		NM_001005171	NP_001005171	Q8NGK4	O52K1_HUMAN	olfactory receptor, family 52, subfamily K,	110	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.76e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0836)|LUSC - Lung squamous cell carcinoma(625;0.192)		ACTCCTTCTCCATCATGGAGT	0.527													21	18					0	0	0.001523	0	0
OR51E2	81285	broad.mit.edu	37	11	4703277	4703277	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:4703277C>T	uc001lzk.2	-	2	909	c.665G>A	c.(664-666)CGA>CAA	p.R222Q		NM_030774	NP_110401	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(3)|ovary(2)	5		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		CAGAACCGTTCGTATTATCAG	0.488													38	42					0	0	0.004878	0	0
OR51A7	119687	broad.mit.edu	37	11	4928635	4928635	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:4928635C>T	uc010qyq.1	+	1	36	c.36C>T	c.(34-36)TTC>TTT	p.F12F		NM_001004749	NP_001004749	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A,	12	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCAAGCTTTTCCTTCTGATTG	0.458													20	40					0	0	0.001882	0	0
OR56B4	196335	broad.mit.edu	37	11	6129257	6129257	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:6129257C>T	uc010qzx.1	+	1	249	c.249C>T	c.(247-249)ATC>ATT	p.I83I		NM_001005181	NP_001005181	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B,	83	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCACCACCATCATGCCCAAGA	0.493													33	36					0	0	0.002445	0	0
OR52B2	255725	broad.mit.edu	37	11	6191344	6191344	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:6191344C>T	uc010qzy.1	-	1	213	c.213G>A	c.(211-213)ATG>ATA	p.M71I		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	71	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCAGGATGTCCATGACGGCCA	0.493													84	85					0	0	0.003610	0	0
TMEM41B	440026	broad.mit.edu	37	11	9321194	9321194	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:9321194G>A	uc001mhm.2	-	2	484	c.176C>T	c.(175-177)TCC>TTC	p.S59F	TMEM41B_uc001mhn.1_Missense_Mutation_p.S59F	NM_015012	NP_055827	Q5BJD5	TM41B_HUMAN	transmembrane protein 41B isoform 1	59	Helical; (Potential).					integral to membrane					0				all cancers(16;9.96e-08)|Epithelial(150;4.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0972)		TAAGAAAATGGACACCAATAT	0.308													46	44					0	0	0.003610	0	0
SWAP70	23075	broad.mit.edu	37	11	9771499	9771499	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:9771499G>A	uc001mhw.2	+	12	1839	c.1740G>A	c.(1738-1740)GAG>GAA	p.E580E	SWAP70_uc001mhx.2_Silent_p.E522E	NM_015055	NP_055870	Q9UH65	SWP70_HUMAN	SWAP-70 protein	580				Missing: Affects targeting to loose actin filament arrays.		cytoplasm|lamellipodium|nucleus|plasma membrane	calcium ion binding|DNA binding			ovary(2)|central_nervous_system(1)	3				all cancers(16;1.21e-10)|Epithelial(150;2.81e-09)|BRCA - Breast invasive adenocarcinoma(625;0.00649)		ACTGGAAAGAGAAAAAGACCA	0.463													45	38					0	0	0.002852	0	0
IGSF22	283284	broad.mit.edu	37	11	18735421	18735421	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:18735421G>A	uc009yht.2	-	14	2263	c.2073C>T	c.(2071-2073)GCC>GCT	p.A691A	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	691	Ig-like 4.									ovary(4)|large_intestine(2)|kidney(1)	7						GGTGCAGAGTGGCCGTGGCTG	0.637													12	20					0	0	0.000978	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955425	18955425	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:18955425C>T	uc001mpg.2	-	1	1125	c.907G>A	c.(907-909)GAA>AAA	p.E303K		NM_147199	NP_671732	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	303	Cytoplasmic (Potential).				acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(2)|central_nervous_system(1)	3						CCTCCACCTTCATCCACCTCA	0.552													31	55					0	0	0.008361	0	0
ANO5	203859	broad.mit.edu	37	11	22294508	22294508	+	Silent	SNP	A	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:22294508A>T	uc001mqi.2	+	19	2525	c.2208A>T	c.(2206-2208)GGA>GGT	p.G736G	ANO5_uc001mqj.2_Silent_p.G735G	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	736	Helical; (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						TTCTTTATGGAATGGCTGTCC	0.433													55	50					0	0	0.003610	0	0
SLC5A12	159963	broad.mit.edu	37	11	26743063	26743064	+	Missense_Mutation	DNP	CC	AT	AT			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:26743063_26743064CC>AT	uc001mra.2	-	1	511_512	c.198_199GG>AT	c.(196-201)ACGGTC>ACATTC	p.V67F	SLC5A12_uc001mrb.2_Intron|SLC5A12_uc001mrc.3_Missense_Mutation_p.V67F	NM_178498	NP_848593	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/glucose	67	Helical; (Potential).				sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(1)|skin(1)	2						GTCCCCAGGACCGTGACAGCTG	0.51													33	30					0	0	0.004672	0	0
FIBIN	387758	broad.mit.edu	37	11	27016325	27016325	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:27016325C>T	uc001mrd.2	+	1	698	c.252C>T	c.(250-252)TTC>TTT	p.F84F		NM_203371	NP_976249	Q8TAL6	FIBIN_HUMAN	fin bud initiation factor homolog precursor	84						extracellular region|Golgi apparatus					0						GGGAGGAGTTCACCGTGCTGG	0.647													9	17					0	0	0.004482	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137423	40137423	+	Silent	SNP	C	T	T	rs142752772	byFrequency	TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:40137423C>T	uc001mxa.1	-	2	2384	c.420G>A	c.(418-420)CCG>CCA	p.P140P	LRRC4C_uc001mxc.1_Silent_p.P136P|LRRC4C_uc001mxd.1_Silent_p.P136P|LRRC4C_uc001mxb.1_Silent_p.P136P	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	140	LRR 3.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				AAGCTCCATTCGGGATGGTAG	0.423													13	40					0	0	0.001368	0	0
DGKZ	8525	broad.mit.edu	37	11	46400584	46400584	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:46400584A>G	uc001ncn.1	+	29	3151	c.3026A>G	c.(3025-3027)GAC>GGC	p.D1009G	DGKZ_uc001nch.1_Missense_Mutation_p.D837G|DGKZ_uc010rgq.1_3'UTR|DGKZ_uc001ncj.1_Missense_Mutation_p.D787G|DGKZ_uc010rgr.1_Missense_Mutation_p.D786G|DGKZ_uc001nck.1_Missense_Mutation_p.D599G|DGKZ_uc001ncl.2_Missense_Mutation_p.D821G|DGKZ_uc001ncm.2_Missense_Mutation_p.D820G|DGKZ_uc009yky.1_Missense_Mutation_p.D821G|DGKZ_uc010rgs.1_Missense_Mutation_p.D798G|MDK_uc009ykz.1_5'Flank|MDK_uc001nco.2_5'Flank|MDK_uc001ncp.2_5'Flank|MDK_uc009yla.2_5'Flank|MDK_uc009ylb.2_5'Flank|MDK_uc001ncq.2_5'Flank|MDK_uc001ncr.2_5'Flank|MDK_uc001ncs.2_5'Flank	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	1009					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		ATGCACCGAGACGAGCAGAGT	0.682													10	7					0	0	0.006214	0	0
OR4S2	219431	broad.mit.edu	37	11	55418383	55418383	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:55418383G>A	uc001nhs.1	+	1	4	c.4G>A	c.(4-6)GAA>AAA	p.E2K		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	2	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				CCATTCCATGGAAAAAATAAA	0.328													21	43					0	0	0.002299	0	0
OR5D14	219436	broad.mit.edu	37	11	55563503	55563503	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:55563503C>T	uc010rim.1	+	1	472	c.472C>T	c.(472-474)CCC>TCC	p.P158S		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				CATGTTTGGCCCCTTGGTACT	0.493													48	102					0	0	0.003610	0	0
OR9Q2	219957	broad.mit.edu	37	11	57958776	57958776	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:57958776C>T	uc010rka.1	+	1	814	c.814C>T	c.(814-816)CGA>TGA	p.R272*		NM_001005283	NP_001005283	Q8NGE9	OR9Q2_HUMAN	olfactory receptor, family 9, subfamily Q,	272	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)|central_nervous_system(1)	4		Breast(21;0.0589)				CGAGGGAGACCGAGTGGTGTC	0.557													41	82					0	0	0.003610	0	0
OR5B3	441608	broad.mit.edu	37	11	58170180	58170180	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:58170180G>A	uc010rkf.1	-	1	703	c.703C>T	c.(703-705)CCT>TCT	p.P235S		NM_001005469	NP_001005469	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GTGGACAAAGGCTTCTGGTAT	0.423													19	40					0	0	0.006122	0	0
GLYATL1	92292	broad.mit.edu	37	11	58722674	58722674	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:58722674G>A	uc001nnf.2	+	7	715	c.339G>A	c.(337-339)GGG>GGA	p.G113G	uc001nng.1_Intron|GLYATL1_uc001nnh.1_Silent_p.G144G|GLYATL1_uc001nni.1_Silent_p.G113G|GLYATL1_uc001nnj.1_Silent_p.G113G			Q969I3	GLYL1_HUMAN	SubName: Full=Glycine acyltransferase family-C; SubName: Full=Glycine-N-acyltransferase-like 1, isoform CRA_a;	113						mitochondrion	glycine N-acyltransferase activity			ovary(1)	1					Glycine(DB00145)	TAGGTGAGGGGATAAGAGTGG	0.428													34	56					0	0	0.003755	0	0
C11orf9	745	broad.mit.edu	37	11	61539203	61539203	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:61539203G>A	uc001nsc.1	+	6	1068	c.972G>A	c.(970-972)CCG>CCA	p.P324P	C11orf9_uc001nse.1_Silent_p.P315P	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	324	NDT80.|Pro-rich.				central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						CTTGGCACCCGCCAGGTGCCC	0.697													22	112					0	0	0.003330	0	0
SLC22A25	387601	broad.mit.edu	37	11	62997100	62997100	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:62997100G>A	uc001nwr.1	-	1	25	c.25C>T	c.(25-27)CAA>TAA	p.Q9*	SLC22A10_uc010rmo.1_Intron|SLC22A25_uc009yoq.1_RNA|SLC22A25_uc001nws.1_RNA|SLC22A25_uc001nwt.1_Nonsense_Mutation_p.Q9*	NM_199352	NP_955384	Q6T423	S22AP_HUMAN	putative UST1-like organic anion transporter	9	Cytoplasmic (Potential).				transmembrane transport	integral to membrane				ovary(3)|skin(1)	4						CCTCCAACTTGATCTAGGAGG	0.438													18	45					0	0	0.008871	0	0
ZFPL1	7542	broad.mit.edu	37	11	64854200	64854200	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:64854200G>A	uc001ocq.1	+	5	582	c.417G>A	c.(415-417)GAG>GAA	p.E139E	CDCA5_uc001ocp.2_5'Flank	NM_006782	NP_006773	O95159	ZFPL1_HUMAN	zinc finger protein-like 1	139	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|vesicle-mediated transport	Golgi apparatus|integral to membrane|nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGATCGATGAGGTGGTGAGCC	0.562													35	52					0	0	0.004878	0	0
SF3B2	10992	broad.mit.edu	37	11	65824394	65824394	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:65824394A>G	uc001ogy.1	+	6	675	c.635A>G	c.(634-636)CAG>CGG	p.Q212R	SF3B2_uc001ogx.1_Missense_Mutation_p.Q211R	NM_006842	NP_006833	Q13435	SF3B2_HUMAN	splicing factor 3B subunit 2	212					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(2)|breast(1)	3						GACATGGGCCAGATTGGTGTG	0.537													26	39					0	0	0.003330	0	0
INPPL1	3636	broad.mit.edu	37	11	71941854	71941854	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:71941854C>T	uc001osf.2	+	11	1359	c.1212C>T	c.(1210-1212)TTC>TTT	p.F404F	INPPL1_uc001osg.2_Silent_p.F162F	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	404					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						GGGAGGCCTTCTGCCAGCTGT	0.607													15	20					0	0	0.003163	0	0
MED17	9440	broad.mit.edu	37	11	93528151	93528151	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:93528151C>T	uc001pem.3	+	6	1212	c.937C>T	c.(937-939)CGG>TGG	p.R313W		NM_004268	NP_004259	Q9NVC6	MED17_HUMAN	mediator complex subunit 17	313					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				ACAGCTCTCTCGGGAAGCTGT	0.403													66	55					0	0	0.003610	0	0
TRPC6	7225	broad.mit.edu	37	11	101375213	101375213	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:101375213C>T	uc001pgk.3	-	2	912	c.487G>A	c.(487-489)GAT>AAT	p.D163N	TRPC6_uc009ywy.2_Missense_Mutation_p.D163N|TRPC6_uc009ywz.1_Missense_Mutation_p.D163N	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	163	Cytoplasmic (Potential).|ANK 3.				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		AGCAAAGCATCCCCAACTCGA	0.463													26	33					0	0	0.003330	0	0
HSPB2	3316	broad.mit.edu	37	11	111784565	111784566	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:111784565_111784566CC>TT	uc001pmg.2	+	2	589_590	c.495_496CC>TT	c.(493-498)CTCCCT>CTTTCT	p.P166S	CRYAB_uc001pmf.1_5'Flank|CRYAB_uc010rwp.1_5'Flank|HSPB2_uc009yyj.2_RNA|C11orf52_uc001pmh.2_Intron	NM_001541	NP_001532	Q16082	HSPB2_HUMAN	heat shock 27kDa protein 2	166					response to heat|response to unfolded protein	cytosol|nucleus	enzyme activator activity|protein binding			ovary(2)|skin(1)	3		all_cancers(61;3.75e-11)|all_epithelial(67;2.33e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;3.57e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|all cancers(92;6.57e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.051)		TCTCCCTGCTCCCTGCGCCTCC	0.574													19	30					0	0	0.004672	0	0
MLL	4297	broad.mit.edu	37	11	118363900	118363900	+	Silent	SNP	A	G	G			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:118363900A>G	uc001pta.2	+	16	5147	c.5124A>G	c.(5122-5124)CTA>CTG	p.L1708L	MLL_uc001ptb.2_Silent_p.L1711L	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1708	Bromo; divergent.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CTTTAGATCTAGAAGGAGTCA	0.468			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								35	31					0	0	0.004878	0	0
MLL	4297	broad.mit.edu	37	11	118372446	118372446	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:118372446C>T	uc001pta.2	+	26	6393	c.6370C>T	c.(6370-6372)CGA>TGA	p.R2124*	MLL_uc001ptb.2_Nonsense_Mutation_p.R2127*	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2124					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		ATCACCAGACCGACCTCCTCA	0.428			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								34	70					0	0	0.004878	0	0
FOXR1	283150	broad.mit.edu	37	11	118850239	118850239	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:118850239C>T	uc001pui.2	+	4	697	c.472C>T	c.(472-474)CGG>TGG	p.R158W	FOXR1_uc001puj.2_RNA|FOXR1_uc001puk.2_Intron	NM_181721	NP_859072	Q6PIV2	FOXR1_HUMAN	forkhead box R1	158					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		CCTCCAGAGTCGGAGGCTTCG	0.602													34	51					0	0	0.002445	0	0
OR8B3	390271	broad.mit.edu	37	11	124266550	124266550	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:124266550C>T	uc010saj.1	-	1	698	c.698G>A	c.(697-699)GGA>GAA	p.G233E	OR8B2_uc001qab.3_Intron	NM_001005467	NP_001005467	Q8NGG8	OR8B3_HUMAN	olfactory receptor, family 8, subfamily B,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		TTTTGATCTTCCTTGAGTGGA	0.373													75	56					0	0	0.003610	0	0
RPUSD4	84881	broad.mit.edu	37	11	126073509	126073509	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:126073509G>A	uc001qde.2	-	7	992	c.938C>T	c.(937-939)TCG>TTG	p.S313L	RPUSD4_uc010sbl.1_Missense_Mutation_p.S120L|RPUSD4_uc009zbz.2_Missense_Mutation_p.S282L|RPUSD4_uc009zby.2_RNA	NM_032795	NP_116184	Q96CM3	RUSD4_HUMAN	RNA pseudouridylate synthase domain containing 4	313					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			breast(1)	1	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0761)		GCGGGCCTTCGACTGTTCTAG	0.577													18	42					0	0	0.008871	0	0
OPCML	4978	broad.mit.edu	37	11	132306020	132306020	+	Silent	SNP	C	T	T	rs150470513		TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:132306020C>T	uc001qgs.2	-	6	947	c.897G>A	c.(895-897)ACG>ACA	p.T299T	OPCML_uc001qgu.2_Silent_p.T292T|OPCML_uc010sck.1_Silent_p.T299T|OPCML_uc001qgt.2_Silent_p.T298T|OPCML_uc010scl.1_Silent_p.T258T	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	299	Ig-like C2-type 3.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		CAAGCTTGTTCGTGGCCACAC	0.488													33	25					0	0	0.003755	0	0
KDM5A	5927	broad.mit.edu	37	12	432368	432368	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:432368G>A	uc001qif.1	-	16	2518	c.2155C>T	c.(2155-2157)CGC>TGC	p.R719C	KDM5A_uc001qie.1_Missense_Mutation_p.R719C|KDM5A_uc010sdn.1_Missense_Mutation_p.R678C	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	719					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						AATGGGTAGCGATATCTACaa	0.303			T 	NUP98	AML								6	23					0	0	0.001168	0	0
AKAP3	10566	broad.mit.edu	37	12	4737278	4737278	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:4737278C>T	uc001qnb.3	-	4	1019	c.790G>A	c.(790-792)GAG>AAG	p.E264K		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	264					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6						CTCTTTCTCTCCCGAGGAAAG	0.443													12	54					0	0	0.000978	0	0
CLEC4C	170482	broad.mit.edu	37	12	7882228	7882228	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:7882228C>T	uc001qtg.1	-	6	780	c.606G>A	c.(604-606)CAG>CAA	p.Q202Q	CLEC4C_uc001qth.1_Silent_p.Q202Q|CLEC4C_uc001qti.1_Silent_p.Q171Q	NM_130441	NP_569708	Q8WTT0	CLC4C_HUMAN	C-type lectin domain family 4, member C isoform	202	Extracellular (Potential).|C-type lectin.				innate immune response	integral to membrane	sugar binding			ovary(2)|skin(1)	3				Kidney(36;0.0915)		AAATTGACTTCTGAGGTACAT	0.393													33	22					0	0	0.002096	0	0
A2ML1	144568	broad.mit.edu	37	12	8998726	8998726	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:8998726G>A	uc001quz.3	+	14	1689	c.1591G>A	c.(1591-1593)GAT>AAT	p.D531N	A2ML1_uc001qva.1_Missense_Mutation_p.D111N|A2ML1_uc010sgm.1_Missense_Mutation_p.D31N	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	375						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						ACTGGCCCCTGATCCTTCCCT	0.453													58	46					0	0	0.003610	0	0
TAS2R8	50836	broad.mit.edu	37	12	10958879	10958879	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:10958879A>T	uc010shh.1	-	1	701	c.701T>A	c.(700-702)ATT>AAT	p.I234N		NM_023918	NP_076407	Q9NYW2	TA2R8_HUMAN	taste receptor, type 2, member 8	234	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			ovary(2)	2						CATAGTTTTAATGGCTCTCAC	0.333													36	20					0	0	0.006230	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18691147	18691147	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:18691147G>A	uc001rdt.2	+	24	3374	c.3258G>A	c.(3256-3258)GGG>GGA	p.G1086G	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Silent_p.G1127G|PIK3C2G_uc010sic.1_Silent_p.G905G	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	1086	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				CAGAGGGTGGGAAAAACCCAC	0.398													18	58					0	0	0.006122	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21015416	21015416	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:21015416G>A	uc001rek.2	+	6	678	c.552G>A	c.(550-552)GGG>GGA	p.G184G	SLCO1B3_uc001rel.2_Silent_p.G184G|SLCO1B3_uc010sil.1_Silent_p.G184G|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Silent_p.G9G	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	184	Helical; Name=4; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					GTGGCATAGGGGAAACCCCCA	0.373													21	61					0	0	0.002780	0	0
ALG10B	144245	broad.mit.edu	37	12	38715009	38715009	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:38715009G>A	uc001rln.3	+	3	1555	c.1416G>A	c.(1414-1416)ATG>ATA	p.M472I	ALG10B_uc001rlo.3_Missense_Mutation_p.M442I|ALG10B_uc010skk.1_Missense_Mutation_p.M412I	NM_001013620	NP_001013642	Q5I7T1	AG10B_HUMAN	asparagine-linked glycosylation 10 homolog B	472	Cytoplasmic (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			ovary(2)|skin(1)	3	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				AAAGGTTTATGTGGTAATATC	0.308													64	34					0	0	0.003610	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43826519	43826519	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:43826519C>A	uc010skx.1	-	20	2816	c.2816G>T	c.(2815-2817)GGA>GTA	p.G939V	ADAMTS20_uc001rno.1_Missense_Mutation_p.G93V|ADAMTS20_uc001rnp.1_Missense_Mutation_p.G93V	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	939	TSP type-1 3.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AACAGTCTGTCCTTCATGAAT	0.423													23	72					9.57634e-11	1.56309e-10	0.003330	1	0
FMNL3	91010	broad.mit.edu	37	12	50062307	50062308	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:50062307_50062308GG>AA	uc001ruv.1	-	2	390_391	c.156_157CC>TT	c.(154-159)GCCCGG>GCTTGG	p.R53W	FMNL3_uc001ruw.1_Missense_Mutation_p.R53W	NM_175736	NP_783863	Q8IVF7	FMNL3_HUMAN	formin-like 3 isoform 1	53	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(2)|pancreas(2)	4						CGCAGGAGCCGGGCCTTGTCTG	0.535													17	62					0	0	0.004672	0	0
ACVR1B	91	broad.mit.edu	37	12	52370345	52370345	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:52370345C>T	uc001rzn.2	+	3	608	c.566C>T	c.(565-567)TCA>TTA	p.S189L	ACVR1B_uc001rzl.2_Missense_Mutation_p.S189L|ACVR1B_uc001rzm.2_Missense_Mutation_p.S189L|ACVR1B_uc010snn.1_Missense_Mutation_p.S189L	NM_004302	NP_004293	P36896	ACV1B_HUMAN	activin A receptor, type IB isoform a precursor	189	Cytoplasmic (Potential).|GS.				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			pancreas(4)|breast(2)|ovary(1)|lung(1)|kidney(1)	9				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	CTCTCCACCTCAGGGTCTGGC	0.512													53	49					0	0	0.003610	0	0
KRT71	112802	broad.mit.edu	37	12	52946764	52946764	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:52946764C>T	uc001sao.2	-	1	168	c.98G>A	c.(97-99)CGG>CAG	p.R33Q		NM_033448	NP_258259	Q3SY84	K2C71_HUMAN	keratin 71	33	Head.|Gly-rich.						structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.194)		GCTCCCTGCCCGGAAGGAGGA	0.652													23	85					0	0	0.004656	0	0
PDE1B	5153	broad.mit.edu	37	12	54966496	54966496	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:54966496C>T	uc001sgd.1	+	7	872	c.706C>T	c.(706-708)CAT>TAT	p.H236Y	PDE1B_uc010soz.1_Missense_Mutation_p.H99Y|PDE1B_uc010spa.1_Missense_Mutation_p.H195Y|PDE1B_uc001sgf.2_Missense_Mutation_p.H99Y|PDE1B_uc001sge.2_Missense_Mutation_p.H216Y|PDE1B_uc009znq.2_Missense_Mutation_p.H32Y	NM_000924	NP_000915	Q01064	PDE1B_HUMAN	phosphodiesterase 1B isoform 1	236	Catalytic (By similarity).				activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CCAGACAGTCCATTGCTTCTT	0.507													147	98					0	0	0.003610	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420514	55420514	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:55420514G>A	uc001sgp.3	+	2	669	c.291G>A	c.(289-291)CGG>CGA	p.R97R		NM_021191	NP_067014	Q9HD90	NDF4_HUMAN	neurogenic differentiation 4	97	Basic motif.				amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4						CCAGAGAACGGACCCGGATGC	0.498													11	55					0	0	0.008291	0	0
OR6C74	254783	broad.mit.edu	37	12	55641850	55641850	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:55641850C>T	uc010spg.1	+	1	779	c.779C>T	c.(778-780)CCC>CTC	p.P260L		NM_001005490	NP_001005490	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C,	260	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TATGTGAAACCCTCAGCAAAA	0.403													38	31					0	0	0.006230	0	0
OR6C1	390321	broad.mit.edu	37	12	55714592	55714592	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:55714592C>T	uc010spi.1	+	1	209	c.209C>T	c.(208-210)TCG>TTG	p.S70L		NM_001005182	NP_001005182	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2						TTAGAAATTTCGTTCACAACC	0.378													26	20					0	0	0.003330	0	0
OR6C4	341418	broad.mit.edu	37	12	55945095	55945095	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:55945095C>T	uc010spp.1	+	1	85	c.85C>T	c.(85-87)CTG>TTG	p.L29L		NM_001005494	NP_001005494	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C,	29	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATTCATCTTTCTGTTCCTCAC	0.428													67	37					0	0	0.003610	0	0
C12orf50	160419	broad.mit.edu	37	12	88376883	88376883	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:88376883G>A	uc001tam.1	-	12	1384	c.1216C>T	c.(1216-1218)CCA>TCA	p.P406S		NM_152589	NP_689802	Q8NA57	CL050_HUMAN	hypothetical protein LOC160419	406										skin(2)|ovary(1)	3						TAGTTACCTGGATATATCTTT	0.289													46	24					0	0	0.003214	0	0
UTP20	27340	broad.mit.edu	37	12	101767224	101767224	+	Silent	SNP	C	T	T	rs112278934	byFrequency	TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:101767224C>T	uc001tia.1	+	53	7080	c.6924C>T	c.(6922-6924)GCC>GCT	p.A2308A		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	2308					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						AAATGATCGCCTATCTCTTTG	0.458													25	30					0	0	0.008361	0	0
TRPV4	59341	broad.mit.edu	37	12	110240830	110240830	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:110240830G>A	uc001tpj.1	-	3	773	c.678C>T	c.(676-678)TTC>TTT	p.F226F	TRPV4_uc001tpg.1_Silent_p.F192F|TRPV4_uc001tph.1_Silent_p.F226F|TRPV4_uc001tpi.1_Silent_p.F226F|TRPV4_uc001tpk.1_Silent_p.F226F|TRPV4_uc001tpl.1_Silent_p.F226F	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	226	Cytoplasmic (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						GCGAGTTAATGAACTCCCTCA	0.627													24	12					0	0	0.002780	0	0
CLIP1	6249	broad.mit.edu	37	12	122812709	122812709	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:122812709C>T	uc001ucg.1	-	16	3140	c.3034G>A	c.(3034-3036)GAA>AAA	p.E1012K	CLIP1_uc001uch.1_Missense_Mutation_p.E1001K|CLIP1_uc001uci.1_Missense_Mutation_p.E966K|CLIP1_uc001ucj.1_Missense_Mutation_p.E587K	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	1012	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		ATTTTCTTTTCCTGCAGAGAC	0.493													18	114					0	0	0.003755	0	0
PITPNM2	57605	broad.mit.edu	37	12	123489905	123489905	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:123489905G>A	uc001uej.1	-	6	973	c.834C>T	c.(832-834)GAC>GAT	p.D278D	PITPNM2_uc001uek.1_Silent_p.D278D|PITPNM2_uc009zxu.1_Silent_p.D278D	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	278					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		CAGAGGTCTGGTCCGAGACGG	0.617													50	30					0	0	0.003610	0	0
TMEM132B	114795	broad.mit.edu	37	12	126068397	126068397	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:126068397G>C	uc001uhe.1	+	5	1287	c.1279G>C	c.(1279-1281)GAC>CAC	p.D427H		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	427	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		TCCTGTTTAGGACACCGAGGT	0.547													9	208					0	0	0.006214	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	A	A	rs12366766		TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:132547087G>A	uc001ujn.2	+	46	8210	c.8175G>A	c.(8173-8175)CAG>CAA	p.Q2725Q	EP400_uc001ujl.2_Silent_p.Q2724Q|EP400_uc001ujm.2_Silent_p.Q2644Q|EP400_uc001ujp.2_5'UTR	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Poly-Gln.|Interaction with ZNF42 (By similarity).				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.289													7	39					0	0	0.001984	0	0
SACS	26278	broad.mit.edu	37	13	23910492	23910492	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr13:23910492C>T	uc001uon.2	-	10	8112	c.7523G>A	c.(7522-7524)AGA>AAA	p.R2508K	SACS_uc001uoo.2_Missense_Mutation_p.R2361K|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	2508					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GGATGCATATCTTTCTAAGGC	0.393													18	81					0	0	0.001523	0	0
ATP12A	479	broad.mit.edu	37	13	25276115	25276115	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr13:25276115A>C	uc001upp.2	+	14	2111	c.1924A>C	c.(1924-1926)ATT>CTT	p.I642L	ATP12A_uc010aaa.2_Missense_Mutation_p.I648L	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	642	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	AGCCAAAGCTATTGCCAAGAG	0.473													82	52					0	0	0.003610	0	0
MTUS2	23281	broad.mit.edu	37	13	29599560	29599560	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr13:29599560G>A	uc001usl.3	+	1	813	c.755G>A	c.(754-756)CGT>CAT	p.R252H		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	242						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						AAGAGTGTGCGTCATCCTAAA	0.562													15	10					0	0	0.003163	0	0
HMGB1	3146	broad.mit.edu	37	13	31036680	31036680	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr13:31036680C>T	uc001usw.2	-	4	650	c.466G>A	c.(466-468)GAA>AAA	p.E156K	HMGB1_uc001usz.2_Missense_Mutation_p.E156K|HMGB1_uc001usv.2_Missense_Mutation_p.E156K|HMGB1_uc001usx.2_Missense_Mutation_p.E156K|HMGB1_uc001usy.2_Missense_Mutation_p.E117K|HMGB1_uc001uta.1_Missense_Mutation_p.E156K	NM_002128	NP_002119	P09429	HMGB1_HUMAN	high-mobility group box 1	156	HMG box 2.		E -> Q.		base-excision repair, DNA ligation|dendritic cell chemotaxis|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|inflammatory response to antigenic stimulus|innate immune response|myeloid dendritic cell activation|negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|neuron projection development|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	cell surface|condensed chromosome|extracellular space|nucleolus|nucleoplasm	chemoattractant activity|cytokine activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|repressing transcription factor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			ovary(1)	1		Lung SC(185;0.0257)		all cancers(112;0.072)|OV - Ovarian serous cystadenocarcinoma(117;0.177)|Lung(94;0.216)|GBM - Glioblastoma multiforme(144;0.232)		CTTACCTTTTCATATTTTTCC	0.403													6	84					0	0	0.001168	0	0
CSNK1A1L	122011	broad.mit.edu	37	13	37679106	37679106	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr13:37679106G>A	uc001uwm.1	-	1	696	c.288C>T	c.(286-288)AGC>AGT	p.S96S		NM_145203	NP_660204	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	96	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)	1		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		GGTCTTCGAGGCTGGGTCCCA	0.453													20	57					0	0	0.008871	0	0
ATP7B	540	broad.mit.edu	37	13	52548946	52548946	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr13:52548946G>A	uc001vfw.2	-	2	567	c.410C>T	c.(409-411)TCC>TTC	p.S137F	ATP7B_uc010adv.2_Missense_Mutation_p.S137F|ATP7B_uc001vfx.2_Missense_Mutation_p.S137F|ATP7B_uc001vfy.2_Missense_Mutation_p.S137F|ATP7B_uc010tgt.1_Missense_Mutation_p.S137F|ATP7B_uc010tgu.1_Missense_Mutation_p.S137F|ATP7B_uc010tgv.1_Missense_Mutation_p.S137F|ATP7B_uc010tgw.1_Missense_Mutation_p.S105F	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	137	Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		GGCAGGCAAGGACCTTGAGGG	0.592									Wilson_disease				40	15					0	0	0.006999	0	0
SLITRK1	114798	broad.mit.edu	37	13	84453942	84453942	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr13:84453942C>T	uc001vlk.2	-	1	2587	c.1701G>A	c.(1699-1701)AAG>AAA	p.K567K		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	567	LRRCT 2.|Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GCATGAAATCCTTTCTAAAGA	0.527													7	35					0	0	0.001984	0	0
STK24	8428	broad.mit.edu	37	13	99127125	99127125	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr13:99127125G>A	uc001vnm.1	-	5	818	c.583C>T	c.(583-585)CCA>TCA	p.P195S	STK24_uc001vnn.1_Missense_Mutation_p.P183S|STK24_uc010tim.1_Missense_Mutation_p.P164S	NM_003576	NP_003567	Q9Y6E0	STK24_HUMAN	serine/threonine kinase 24 isoform a	195	Protein kinase.				cellular component disassembly involved in apoptosis|signal transduction	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			ATCCAGAATGGGGTGCCCACG	0.632													54	28					0	0	0.003610	0	0
FAM155A	728215	broad.mit.edu	37	13	108518337	108518337	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr13:108518337T>C	uc001vql.2	-	1	1124	c.608A>G	c.(607-609)GAC>GGC	p.D203G		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	203						integral to membrane	binding			skin(1)	1						CTCCTGCCCGTCCCCCCCGGC	0.607													3	86					0	0	0.000248	0	0
PRMT5	10419	broad.mit.edu	37	14	23393227	23393227	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr14:23393227G>A	uc001whm.1	-	12	1456	c.1365C>T	c.(1363-1365)CAC>CAT	p.H455H	PRMT5_uc001whl.1_Silent_p.H438H|PRMT5_uc010akd.1_RNA|PRMT5_uc010tnf.1_Silent_p.H349H|PRMT5_uc010tng.1_Silent_p.H394H|PRMT5_uc010tnh.1_Silent_p.H411H|PRMT5_uc001whn.1_Silent_p.H284H	NM_006109	NP_006100	O14744	ANM5_HUMAN	protein arginine methyltransferase 5 isoform a	455					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			ovary(1)	1	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		CTTTTAGGAAGTGCTGGGCTC	0.493													34	168					0	0	0.003214	0	0
DACT1	51339	broad.mit.edu	37	14	59113645	59113645	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr14:59113645G>A	uc001xdw.2	+	4	2468	c.2304G>A	c.(2302-2304)GGG>GGA	p.G768G	DACT1_uc010trv.1_Silent_p.G487G|DACT1_uc001xdx.2_Silent_p.G731G|DACT1_uc010trw.1_Silent_p.G487G	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	768					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						AGTTCGTGGGGGAGAGCACAA	0.582													51	32					0	0	0.003610	0	0
Unknown	0	broad.mit.edu	37	14	66480060	66480060	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr14:66480060G>A	uc001xit.2	-	1	573	c.448C>T	c.(448-450)CCT>TCT	p.P150S						SubName: Full=Nuclease sensitive element binding protein-1;																		TTGCGTGGAGGACCCCTAGGA	0.527													31	32					0	0	0.008361	0	0
EXD2	55218	broad.mit.edu	37	14	69704552	69704552	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr14:69704552A>T	uc001xkt.2	+	10	1837	c.1178A>T	c.(1177-1179)CAG>CTG	p.Q393L	EXD2_uc001xku.2_Missense_Mutation_p.Q263L|EXD2_uc001xkv.2_Missense_Mutation_p.Q518L|EXD2_uc001xkw.2_Missense_Mutation_p.Q393L|EXD2_uc010aqt.2_Missense_Mutation_p.Q518L|EXD2_uc010tte.1_Missense_Mutation_p.Q518L|EXD2_uc001xky.2_Missense_Mutation_p.Q393L	NM_018199	NP_060669	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2	393					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding				0						CTGCCTACTCAGCGAAAGGAG	0.607													25	12					0	0	0.004656	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634966	70634966	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr14:70634966G>A	uc001xly.2	-	2	928	c.174C>T	c.(172-174)GTC>GTT	p.V58V	SLC8A3_uc001xlw.2_Silent_p.V58V|SLC8A3_uc001xlx.2_Silent_p.V58V|SLC8A3_uc001xlz.2_Silent_p.V58V|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	58	Extracellular (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TTGGCAGGATGACACCCTCCT	0.547													24	15					0	0	0.006320	0	0
RGS6	9628	broad.mit.edu	37	14	72936746	72936746	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr14:72936746C>T	uc001xna.3	+	8	1014	c.491C>T	c.(490-492)GCG>GTG	p.A164V	RGS6_uc010ttn.1_Missense_Mutation_p.A164V|RGS6_uc001xmx.3_Missense_Mutation_p.A164V|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.A164V|RGS6_uc010ttp.1_Missense_Mutation_p.A95V|RGS6_uc001xmz.1_Missense_Mutation_p.A25V|RGS6_uc010arg.2_RNA	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	164					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		AGGGCCTTTGCGAGGAAGTGG	0.403													6	46					0	0	0.001168	0	0
PAPLN	89932	broad.mit.edu	37	14	73731022	73731022	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr14:73731022A>C	uc010ttx.1	+	20	3128	c.2965A>C	c.(2965-2967)AAG>CAG	p.K989Q	PAPLN_uc001xnw.3_Missense_Mutation_p.K962Q|PAPLN_uc010arl.2_RNA|PAPLN_uc010ttw.1_RNA|PAPLN_uc010tty.1_Missense_Mutation_p.K973Q|PAPLN_uc010arm.2_Missense_Mutation_p.K188Q|PAPLN_uc010arn.2_Missense_Mutation_p.K189Q	NM_173462	NP_775733	O95428	PPN_HUMAN	papilin	989	Ig-like C2-type 1.					proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		CGACTCCCAGAAGATCCAACT	0.657													37	28					0	0	0.006230	0	0
DLST	1743	broad.mit.edu	37	14	75365133	75365133	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr14:75365133C>T	uc001xqv.2	+	11	895	c.832C>T	c.(832-834)CTA>TTA	p.L278L	DLST_uc001xqu.2_Silent_p.L190L|DLST_uc001xqt.2_Silent_p.L194L|DLST_uc010tuw.1_Silent_p.L192L|DLST_uc001xqs.2_RNA|DLST_uc010tuv.1_Silent_p.L278L	NM_001933	NP_001924	P36957	ODO2_HUMAN	dihydrolipoamide S-succinyltransferase (E2	278					lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	dihydrolipoyllysine-residue succinyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00698)		TAACCTCAAACTAGGCTTCAT	0.458													14	48					0	0	0.001855	0	0
KIAA1409	57578	broad.mit.edu	37	14	94063707	94063707	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr14:94063707G>A	uc001ybv.1	+	21	2745	c.2662G>A	c.(2662-2664)GAA>AAA	p.E888K	KIAA1409_uc001ybs.1_Missense_Mutation_p.E888K	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1065						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		CATTGCAGTGGAAAAAGTTGC	0.423													6	51					0	0	0.001984	0	0
SERPINA1	5265	broad.mit.edu	37	14	94844815	94844815	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr14:94844815C>T	uc001ycx.3	-	5	1489	c.1228G>A	c.(1228-1230)GGA>AGA	p.G410R	SERPINA1_uc001ycw.3_RNA|SERPINA1_uc010auw.2_Missense_Mutation_p.G410R|SERPINA1_uc010aux.2_Missense_Mutation_p.G410R|SERPINA1_uc001ycy.3_Missense_Mutation_p.G410R|SERPINA1_uc010auy.2_Missense_Mutation_p.G410R|SERPINA1_uc001ycz.3_Missense_Mutation_p.G410R|SERPINA1_uc010auz.2_Missense_Mutation_p.G410R|SERPINA1_uc010ava.2_Missense_Mutation_p.G410R|SERPINA1_uc001ydb.3_Missense_Mutation_p.G410R|SERPINA1_uc010avb.2_Missense_Mutation_p.G410R|SERPINA1_uc001ydc.3_Missense_Mutation_p.G410R	NM_000295	NP_000286	P01009	A1AT_HUMAN	serine proteinase inhibitor, clade A, member 1	410				G -> L (in Ref. 24; AA sequence).	acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			skin(1)	1		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	ACCACTTTTCCCATGAAGAGG	0.493									Alpha-1-Antitrypsin_Deficiency				78	49					0	0	0.003610	0	0
TCL6	27004	broad.mit.edu	37	14	96136873	96136873	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr14:96136873C>T	uc001yeq.2	+	6	1822	c.353C>T	c.(352-354)CCT>CTT	p.P118L	TCL6_uc001yep.1_RNA|TCL6_uc001yes.2_3'UTR|TCL6_uc001yet.1_Missense_Mutation_p.P60L|TCL6_uc001yeu.2_3'UTR|TCL6_uc001yev.2_Intron|TCL1B_uc001yew.2_RNA|TCL1B_uc001yex.2_RNA|TCL1B_uc010avj.2_RNA|TCL6_uc010avk.1_RNA	NM_020554	NP_065579			SubName: Full=T-cell leukemia/lymphoma 6 ORF163;												0		all_cancers(154;0.103)		Epithelial(152;0.0655)|all cancers(159;0.149)|BRCA - Breast invasive adenocarcinoma(234;0.206)|COAD - Colon adenocarcinoma(157;0.207)		CTTCCTTCTCCTTCTTGGAGT	0.517			T	TRA@	T-ALL								8	25					0	0	0.006214	0	0
AHNAK2	113146	broad.mit.edu	37	14	105413481	105413481	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr14:105413481G>A	uc010axc.1	-	7	8427	c.8307C>T	c.(8305-8307)GCC>GCT	p.A2769A	AHNAK2_uc001ypx.2_Silent_p.A2669A	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2769						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCACATCGGGGGCTGTCACTT	0.622													128	72					0	0	0.003610	0	0
ADAM6	8755	broad.mit.edu	37	14	106405666	106405666	+	RNA	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr14:106405666G>A	uc010tyt.1	-	2358		c.42398C>T								Parts of antibodies, mostly variable regions.												0						CAGCTGCAGGGAGAACTGGTT	0.493													101	43					0	0	0.003610	0	0
ADAM6	8755	broad.mit.edu	37	14	106780678	106780678	+	RNA	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr14:106780678C>T	uc010tyt.1	-	413		c.15184G>A								Parts of antibodies, mostly variable regions.												0						CCAGTCCCTTCCCTGGGGGCT	0.562													22	114					0	0	0.001882	0	0
OR4M2	390538	broad.mit.edu	37	15	22368906	22368906	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr15:22368906G>A	uc010tzu.1	+	1	331	c.331G>A	c.(331-333)GAG>AAG	p.E111K	LOC727924_uc001yua.2_RNA|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	111	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TGGGGCTTCGGAGATGTTCTT	0.468													61	358					0	0	0.003610	0	0
Unknown	0	broad.mit.edu	37	15	22473102	22473102	+	RNA	SNP	C	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr15:22473102C>A	uc001yuj.1	-	2		c.169G>T								Homo sapiens IGH mRNA for immunoglobulin heavy chain VHDJ region, partial cds, clone:H6.																		GGCTGGCGGACCCAGCTCCAC	0.602													57	186					1.12612e-26	1.87109e-26	0.003610	1	0
C15orf2	23742	broad.mit.edu	37	15	24923342	24923342	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr15:24923342C>T	uc001ywo.2	+	1	2802	c.2328C>T	c.(2326-2328)GCC>GCT	p.A776A		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	776					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		AATTTGGGGCCCCTGATGGGC	0.552													67	104					0	0	0.003610	0	0
AVEN	57099	broad.mit.edu	37	15	34168175	34168175	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr15:34168175C>T	uc001zhj.2	-	3	523	c.467G>A	c.(466-468)CGG>CAG	p.R156Q		NM_020371	NP_065104	Q9NQS1	AVEN_HUMAN	cell death regulator aven	156					anti-apoptosis|apoptosis	endomembrane system|intracellular|membrane|membrane fraction	protein binding			kidney(1)	1		all_lung(180;1.78e-08)		all cancers(64;1.66e-15)|GBM - Glioblastoma multiforme(113;1.42e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0359)		CTCAGCAAACCGGAACTGTGA	0.408													14	22					0	0	0.006122	0	0
SEMA6D	80031	broad.mit.edu	37	15	48052082	48052082	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr15:48052082C>T	uc010bek.2	+	2	447	c.87C>T	c.(85-87)CCC>CCT	p.P29P	SEMA6D_uc001zvw.2_Silent_p.P29P|SEMA6D_uc001zvx.1_Silent_p.P29P|SEMA6D_uc001zvy.2_Silent_p.P29P|SEMA6D_uc001zvz.2_Silent_p.P29P|SEMA6D_uc001zwa.2_Silent_p.P29P|SEMA6D_uc001zwb.2_Silent_p.P29P|SEMA6D_uc001zwc.2_Silent_p.P29P	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	29	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		ATGATGAACCCCTTAATACTG	0.448													25	49					0	0	0.006320	0	0
GCOM1	145781	broad.mit.edu	37	15	57925928	57925928	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr15:57925928C>T	uc002aei.2	+	8	1041	c.922C>T	c.(922-924)CGC>TGC	p.R308C	GCOM1_uc002aej.2_Missense_Mutation_p.R308C|GCOM1_uc002aek.2_RNA|GCOM1_uc002ael.2_RNA|GCOM1_uc002aem.2_Missense_Mutation_p.R308C|GCOM1_uc002aeq.2_RNA|GCOM1_uc002aen.2_RNA|GCOM1_uc010bfy.2_RNA|GCOM1_uc002aeo.2_Missense_Mutation_p.R308C|GCOM1_uc002aep.2_RNA|GCOM1_uc010bfx.2_RNA	NM_001018100	NP_001018110	P0CAP1	GCOM1_HUMAN	GRINL1A upstream protein isoform 7	308	Potential.				intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				ovary(1)	1						GCTGATTGAGCGCATGGAAAA	0.507													40	37					0	0	0.002522	0	0
DAPK2	23604	broad.mit.edu	37	15	64332401	64332401	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr15:64332401C>T	uc002amr.2	-	2	91	c.60G>A	c.(58-60)GAG>GAA	p.E20E	DAPK2_uc010uim.1_RNA|DAPK2_uc010bgu.1_Silent_p.E10E	NM_014326	NP_055141	Q9UIK4	DAPK2_HUMAN	death-associated kinase 2	20					apoptosis|induction of apoptosis|intracellular protein kinase cascade	cytoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|identical protein binding			stomach(1)|central_nervous_system(1)	2				LUAD - Lung adenocarcinoma(2;0.215)		CATAAAAGTCCTCCACCTTCT	0.527													31	63					0	0	0.002836	0	0
DPP8	54878	broad.mit.edu	37	15	65756209	65756209	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr15:65756209A>C	uc002aov.2	-	15	3487	c.1909T>G	c.(1909-1911)TCT>GCT	p.S637A	DPP8_uc002aow.2_Missense_Mutation_p.S637A|DPP8_uc010uiv.1_RNA|DPP8_uc002aox.2_Missense_Mutation_p.S621A|DPP8_uc002aoy.2_Missense_Mutation_p.S637A|DPP8_uc002aoz.2_Missense_Mutation_p.S621A|DPP8_uc010bhj.2_Missense_Mutation_p.S637A|DPP8_uc002apa.2_Missense_Mutation_p.S534A|DPP8_uc010bhi.2_5'UTR|DPP8_uc010bhk.1_Missense_Mutation_p.S206A	NM_130434	NP_569118	Q6V1X1	DPP8_HUMAN	dipeptidyl peptidase 8 isoform 1	637					immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			ovary(1)	1						CTTTCAAAAGAGAAAATTTCT	0.398													23	25					0	0	0.003330	0	0
AGBL1	123624	broad.mit.edu	37	15	87531290	87531290	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr15:87531290C>T	uc002blz.1	+	23	3236	c.3156C>T	c.(3154-3156)TTC>TTT	p.F1052F		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	1052					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						caaactttttcaagatgaacc	0.04													72	141					0	0	0.003610	0	0
ABHD2	11057	broad.mit.edu	37	15	89698640	89698640	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr15:89698640G>A	uc002bnj.2	+	10	1330	c.413G>A	c.(412-414)AGC>AAC	p.S138N	ABHD2_uc002bnk.2_Missense_Mutation_p.S138N	NM_007011	NP_008942	P08910	ABHD2_HUMAN	alpha/beta hydrolase domain containing protein	138						integral to membrane	carboxylesterase activity			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					GCCAATCACAGCGAGAAGCAA	0.478													39	54					0	0	0.003610	0	0
IGF1R	3480	broad.mit.edu	37	15	99500369	99500369	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr15:99500369G>A	uc002bul.2	+	21	3852	c.3802G>A	c.(3802-3804)GAG>AAG	p.E1268K	IGF1R_uc010bon.2_Missense_Mutation_p.E1267K	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	1268	Protein kinase.|Cytoplasmic (Potential).				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	CAGCATCAAAGAGGAGATGGA	0.567													25	33					0	0	0.002780	0	0
TNP2	7142	broad.mit.edu	37	16	11362754	11362754	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr16:11362754G>A	uc002das.2	-	1	407	c.366C>T	c.(364-366)ATC>ATT	p.I122I	C16orf75_uc002daq.1_Intron	NM_005425	NP_005416	Q05952	STP2_HUMAN	transition protein 2 (during histone to	122					cell differentiation|multicellular organismal development|spermatogenesis	nucleosome|nucleus	DNA binding				0						ACACCTGCTGGATCCTCTTGG	0.562													20	26					0	0	0.001882	0	0
MYH11	4629	broad.mit.edu	37	16	15831463	15831463	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr16:15831463C>T	uc002ddy.2	-	25	3243	c.3136G>A	c.(3136-3138)GAA>AAA	p.E1046K	MYH11_uc002ddv.2_Missense_Mutation_p.E1053K|MYH11_uc002ddw.2_Missense_Mutation_p.E1046K|MYH11_uc002ddx.2_Missense_Mutation_p.E1053K|MYH11_uc010bvg.2_Missense_Mutation_p.E878K	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1046	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CTCTTCTCTTCCTTCTTTAGC	0.587			T	CBFB	AML								18	34					0	0	0.006122	0	0
TMC5	79838	broad.mit.edu	37	16	19474688	19474688	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr16:19474688G>A	uc002dgc.3	+	7	1984	c.1235G>A	c.(1234-1236)CGG>CAG	p.R412Q	TMC5_uc010vaq.1_Missense_Mutation_p.R412Q|TMC5_uc002dgb.3_Missense_Mutation_p.R412Q|TMC5_uc010var.1_Missense_Mutation_p.R412Q|TMC5_uc002dgd.1_Missense_Mutation_p.R166Q|TMC5_uc002dge.3_Missense_Mutation_p.R166Q|TMC5_uc002dgf.3_Missense_Mutation_p.R95Q|TMC5_uc002dgg.3_Missense_Mutation_p.R53Q	NM_001105248	NP_001098718	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5 isoform a	412	Extracellular (Potential).					integral to membrane				skin(1)	1						TCCATTTCCCGGGTAAGTCAG	0.463													44	42					0	0	0.002852	0	0
GPRC5B	51704	broad.mit.edu	37	16	19883787	19883787	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr16:19883787G>A	uc002dgt.2	-	2	489	c.381C>T	c.(379-381)TTC>TTT	p.F127F	GPRC5B_uc010vav.1_Silent_p.F153F	NM_016235	NP_057319	Q9NZH0	GPC5B_HUMAN	G protein-coupled receptor, family C, group 5,	127	Helical; Name=3; (Potential).									lung(1)|breast(1)|skin(1)	3						CGCCCCAGAGGAAGCGGCGGA	0.667													11	20					0	0	0.001855	0	0
SETD1A	9739	broad.mit.edu	37	16	30976574	30976574	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr16:30976574C>T	uc002ead.1	+	7	2197	c.1511C>T	c.(1510-1512)TCC>TTC	p.S504F		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	504	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						TCCAAGTTTTCCTTCTTGGCC	0.602													28	45					0	0	0.001786	0	0
ZNF646	9726	broad.mit.edu	37	16	31090737	31090737	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr16:31090737C>T	uc002eap.2	+	2	3381	c.3092C>T	c.(3091-3093)CCC>CTC	p.P1031L		NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	1031					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						GCAGGCACCCCCTTGGGAGAC	0.587													50	96					0	0	0.003610	0	0
LPCAT2	54947	broad.mit.edu	37	16	55616943	55616943	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr16:55616943C>T	uc002eie.3	+	14	1749	c.1568C>T	c.(1567-1569)TCC>TTC	p.S523F	LPCAT2_uc002eic.2_Missense_Mutation_p.S253F	NM_017839	NP_060309	Q7L5N7	PCAT2_HUMAN	lysophosphatidylcholine acyltransferase 2	523	Lumenal (Potential).				cellular membrane organization|platelet activating factor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|Golgi stack|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding				0						ACAACCCCCTCCACCGCCAGT	0.418													18	35					0	0	0.004990	0	0
CDH8	1006	broad.mit.edu	37	16	61935082	61935082	+	Splice_Site	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr16:61935082C>T	uc002eog.1	-	3	799	c.547_splice	c.e3+1	p.G183_splice		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein						adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		AGCATACATACCCAAAATGGA	0.358													15	24					0	0	0.007413	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67314416	67314416	+	Silent	SNP	T	C	C			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr16:67314416T>C	uc002eso.3	+	1	3004	c.469T>C	c.(469-471)TTA>CTA	p.L157L	PLEKHG4_uc002esp.3_5'UTR|PLEKHG4_uc002esq.3_Silent_p.L157L|PLEKHG4_uc002esr.1_Intron|PLEKHG4_uc010cef.2_Silent_p.L157L|PLEKHG4_uc002ess.3_Silent_p.L157L|PLEKHG4_uc010ceg.2_Intron	NM_015432	NP_056247	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G	157					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		TGGAGACCCTTTATCAGAAAT	0.577													33	72					0	0	0.003271	0	0
HYDIN	54768	broad.mit.edu	37	16	70954741	70954741	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr16:70954741C>T	uc002ezr.2	-	46	7663	c.7535G>A	c.(7534-7536)AGA>AAA	p.R2512K		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	2513	Potential.									ovary(1)|skin(1)	2		Ovarian(137;0.0654)				caggcgctctctctcccGGTC	0.338													7	9					0	0	0.001984	0	0
ZFHX3	463	broad.mit.edu	37	16	72923658	72923658	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr16:72923658G>A	uc002fck.2	-	4	4093	c.3420C>T	c.(3418-3420)ACC>ACT	p.T1140T	ZFHX3_uc002fcl.2_Silent_p.T226T	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	1140					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				ACCTGCGGATGGTGAAGATCT	0.642													14	20					0	0	0.004990	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77327117	77327117	+	Silent	SNP	T	C	C	rs150608248		TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr16:77327117T>C	uc002ffc.3	-	20	3464	c.3045A>G	c.(3043-3045)GAA>GAG	p.E1015E	ADAMTS18_uc010chc.1_Silent_p.E603E	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1015	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						TGCAGAGGAGTTCACGCTTCC	0.527													36	61					0	0	0.006230	0	0
BCMO1	53630	broad.mit.edu	37	16	81314522	81314522	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr16:81314522G>A	uc002fgn.1	+	8	1380	c.1162G>A	c.(1162-1164)GAA>AAA	p.E388K	BCMO1_uc010vnp.1_Missense_Mutation_p.E319K	NM_017429	NP_059125	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase	388					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity				0						GGCCCTGAAGGAAGAAGATGG	0.413													11	9					0	0	0.000978	0	0
ZCCHC14	23174	broad.mit.edu	37	16	87448144	87448144	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr16:87448144C>T	uc002fjz.1	-	10	1095	c.1068G>A	c.(1066-1068)GAG>GAA	p.E356E	ZCCHC14_uc002fka.1_RNA|ZCCHC14_uc002fkb.2_Silent_p.E132E	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	356					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			upper_aerodigestive_tract(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0285)		TCTCTGACTTCTCCCTGTGAA	0.632													13	17					0	0	0.002450	0	0
CDH15	1013	broad.mit.edu	37	16	89245928	89245928	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr16:89245928C>T	uc002fmt.2	+	2	224	c.147C>T	c.(145-147)ATC>ATT	p.I49I	CDH15_uc010cij.1_Silent_p.I49I	NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	49					adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		CCTGGGTCATCCCCCCGATCA	0.682													31	48					0	0	0.003755	0	0
PIK3R5	23533	broad.mit.edu	37	17	8792001	8792001	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr17:8792001C>T	uc002glt.2	-	10	1170	c.1103G>A	c.(1102-1104)GGG>GAG	p.G368E	PIK3R5_uc010vuz.1_Missense_Mutation_p.G368E|PIK3R5_uc002glu.3_5'UTR|PIK3R5_uc010coa.1_Missense_Mutation_p.G317S|PIK3R5_uc010cob.1_5'UTR	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	368				DILQEILLKEQELLQPGILGDDEEEEEEEEEVEEDLETDGH CAERDSLLSTSSLASHDSTLSLASSQASG -> GNIEGDPG PRRPDSAGLASLQTSCRKSCSRNRSYSSQGSWEMMKRRERR RRRWRRTWKLTGTVPREIPCS (in Ref. 6; AAW63121).	platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						GAGGGCCGGCCCCGAGGCCTG	0.627													6	47					0	0	0.003080	0	0
MYH1	4619	broad.mit.edu	37	17	10406157	10406157	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr17:10406157G>A	uc002gmo.2	-	24	3103	c.3009C>T	c.(3007-3009)CTC>CTT	p.L1003L	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1003	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						GGGCCTCCTGGAGAGCCTTCT	0.498													29	154					0	0	0.002836	0	0
C17orf39	79018	broad.mit.edu	37	17	17957494	17957494	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr17:17957494C>T	uc002gsg.1	+	3	720	c.552C>T	c.(550-552)CAC>CAT	p.H184H		NM_024052	NP_076957	Q8IVV7	CQ039_HUMAN	hypothetical protein LOC79018	184								p.H184P(1)		skin(1)	1	all_neural(463;0.228)					GCAAAAAACACCCTTTCTTAA	0.413													8	53					0	0	0.004482	0	0
MYO15A	51168	broad.mit.edu	37	17	18023225	18023225	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr17:18023225C>T	uc010vxh.1	+	2	1449	c.1111C>T	c.(1111-1113)CCC>TCC	p.P371S		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	371	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					CTACTTTGATCCCTACGGAGT	0.592													21	111					0	0	0.002299	0	0
LLGL1	3996	broad.mit.edu	37	17	18139963	18139963	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr17:18139963G>A	uc002gsp.2	+	12	1456	c.1395G>A	c.(1393-1395)GTG>GTA	p.V465V		NM_004140	NP_004131	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1	465	WD 8.				cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|skin(2)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)	6	all_neural(463;0.228)					CCTCGGGTGTGGCGCTGCGGC	0.667													51	28					0	0	0.003610	0	0
SLFN11	91607	broad.mit.edu	37	17	33680383	33680383	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr17:33680383C>T	uc010ctp.2	-	6	2336	c.1894G>A	c.(1894-1896)GAA>AAA	p.E632K	SLFN11_uc010ctq.2_Missense_Mutation_p.E632K|SLFN11_uc002hjh.3_Missense_Mutation_p.E632K|SLFN11_uc002hjg.3_Missense_Mutation_p.E632K|SLFN11_uc010ctr.2_Missense_Mutation_p.E632K	NM_001104588	NP_001098058	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	632						nucleus	ATP binding			large_intestine(1)|ovary(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GGCTGGTTTTCACAAACGTAG	0.428													10	44					0	0	0.004007	0	0
KRT20	54474	broad.mit.edu	37	17	39036510	39036510	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr17:39036510C>T	uc002hvl.2	-	4	676	c.634G>A	c.(634-636)GTC>ATC	p.V212I		NM_019010	NP_061883	P35900	K1C20_HUMAN	keratin 20	212	Coil 1B.|Rod.				apoptosis|intermediate filament organization	Golgi apparatus|intermediate filament	protein binding|structural constituent of cytoskeleton			large_intestine(1)|kidney(1)|skin(1)	3		Breast(137;0.000301)|Ovarian(249;0.15)				AGGCCATCGACTTCCTATGAA	0.443													13	83					0	0	0.002450	0	0
KRTAP1-5	83895	broad.mit.edu	37	17	39183145	39183145	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr17:39183145A>G	uc002hvu.2	-	1	310	c.263T>C	c.(262-264)ATC>ACC	p.I88T		NM_031957	NP_114163	Q9BYS1	KRA15_HUMAN	keratin associated protein 1.5	88	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament					0		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGGAGCTGATCTGGCAGCA	0.632													3	51					0	0	0.000248	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274416	39274416	+	Missense_Mutation	SNP	C	T	T	rs408579	by1000genomes	TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr17:39274416C>T	uc002hvz.2	-	1	191	c.152G>A	c.(151-153)AGG>AAG	p.R51K		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	51	6.|27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].		Missing (in allele KAP4.14).			keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GCACTGGGGCCTGCAGCAGCT	0.672													4	74					0	0	0.001984	0	0
ACBD4	79777	broad.mit.edu	37	17	43216450	43216450	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr17:43216450C>T	uc002iid.2	+	9	1046	c.702C>T	c.(700-702)TTC>TTT	p.F234F	ACBD4_uc010wjj.1_Silent_p.F250F|ACBD4_uc002iie.2_Silent_p.F250F|ACBD4_uc002iif.2_Nonsense_Mutation_p.R238*|ACBD4_uc002iic.2_Nonsense_Mutation_p.R238*|ACBD4_uc010dae.2_Silent_p.F172F	NM_001135707	NP_001129179	Q8NC06	ACBD4_HUMAN	acyl-Coenzyme A binding domain containing 4	234							fatty-acyl-CoA binding			ovary(1)|kidney(1)	2						GGGGACAGTTCGAGCACTACA	0.682													51	21					0	0	0.003610	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47218690	47218690	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr17:47218690C>A	uc002ion.2	+	2	335	c.276C>A	c.(274-276)TTC>TTA	p.F92L	B4GALNT2_uc010wlt.1_Missense_Mutation_p.F6L|B4GALNT2_uc010wlu.1_Missense_Mutation_p.F32L	NM_153446	NP_703147	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	92	Lumenal (Potential).				lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			large_intestine(1)|ovary(1)	2			all cancers(6;0.000316)			GAAGCATGTTCCTTCAAGCAG	0.502													29	144					1.74807e-11	2.875e-11	0.002096	1	0
SDK2	54549	broad.mit.edu	37	17	71419607	71419607	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr17:71419607C>T	uc010dfm.2	-	14	1815	c.1815G>A	c.(1813-1815)AGG>AGA	p.R605R	SDK2_uc010dfn.2_Silent_p.R284R	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	605	Extracellular (Potential).|Fibronectin type-III 1.				cell adhesion	integral to membrane				ovary(2)	2						TGATGGCTCGCCTTTCCACGG	0.597													4	39					0	0	0.000248	0	0
LAMA1	284217	broad.mit.edu	37	18	7080389	7080389	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr18:7080389C>T	uc002knm.2	-	2	223	c.129G>A	c.(127-129)GAG>GAA	p.E43E	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	43	Laminin N-terminal.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCGGCCCCTTCTCGCCACAGG	0.547													8	45					0	0	0.003080	0	0
CXADRP3	440224	broad.mit.edu	37	18	14478943	14478943	+	RNA	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr18:14478943C>T	uc010xai.1	-	3		c.621G>A				NR_024076				Homo sapiens cDNA clone IMAGE:30390722, containing frame-shift errors.												0						GCTGTAAATTCGTTACATTTA	0.363													8	17					0	0	0.003080	0	0
INSR	3643	broad.mit.edu	37	19	7119574	7119574	+	Missense_Mutation	SNP	C	A	A	rs121913140		TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr19:7119574C>A	uc002mgd.1	-	21	3789	c.3680G>T	c.(3679-3681)TGG>TTG	p.W1227L	INSR_uc002mge.1_Missense_Mutation_p.W1215L	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	1227	Protein kinase.|Cytoplasmic (Potential).		W -> S (in IRAN type A).		activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GGTGATTTCCCAAAGGACCAC	0.383													8	309					0.00448238	0.00724335	0.004482	1	0
MUC16	94025	broad.mit.edu	37	19	9047181	9047181	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr19:9047181C>T	uc002mkp.2	-	5	34654	c.34450G>A	c.(34450-34452)GAA>AAA	p.E11484K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11486	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTCTCTGGTTCATATGGGGTC	0.507													92	44					0	0	0.003610	0	0
MUC16	94025	broad.mit.edu	37	19	9071825	9071825	+	Silent	SNP	T	G	G			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr19:9071825T>G	uc002mkp.2	-	3	15825	c.15621A>C	c.(15619-15621)ACA>ACC	p.T5207T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5209	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTAGAAAACTTGTGTCCGTGG	0.458													40	194					0	0	0.006230	0	0
OR1M1	125963	broad.mit.edu	37	19	9204331	9204331	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr19:9204331C>T	uc010xkj.1	+	1	411	c.411C>T	c.(409-411)AGC>AGT	p.S137S		NM_001004456	NP_001004456	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M,	137	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3						AGATCATGAGCCTACGCCTCT	0.567													88	38					0	0	0.003610	0	0
OR7G3	390883	broad.mit.edu	37	19	9237431	9237431	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr19:9237431G>A	uc010xkl.1	-	1	196	c.196C>T	c.(196-198)CTG>TTG	p.L66L		NM_001001958	NP_001001958	Q8NG95	OR7G3_HUMAN	olfactory receptor, family 7, subfamily G,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ACCAAGGACAGGATAGAGAGG	0.552													74	41					0	0	0.003610	0	0
ZNF266	10781	broad.mit.edu	37	19	9524549	9524550	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr19:9524549_9524550GG>AA	uc002mll.2	-	4	1317_1318	c.1051_1052CC>TT	c.(1051-1053)CCC>TTC	p.P351F	ZNF266_uc002mlm.2_Missense_Mutation_p.P351F|ZNF266_uc002mln.2_Missense_Mutation_p.P351F|ZNF266_uc002mlo.2_Missense_Mutation_p.P351F|ZNF266_uc010dwp.2_Missense_Mutation_p.P351F|ZNF266_uc010dwq.2_Missense_Mutation_p.P351F	NM_198058	NP_932175	Q14584	ZN266_HUMAN	zinc finger protein 266	351					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ACATTTATAGGGTTTTATTCCA	0.411													59	32					0	0	0.004672	0	0
COL5A3	50509	broad.mit.edu	37	19	10079154	10079154	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr19:10079154C>T	uc002mmq.1	-	59	4307	c.4221G>A	c.(4219-4221)TTG>TTA	p.L1407L		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	1407	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			TGAGACCGATCAATCCAATGT	0.582													99	43					0	0	0.003610	0	0
ZNF491	126069	broad.mit.edu	37	19	11917544	11917544	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr19:11917544G>A	uc002mso.1	+	3	1061	c.776G>A	c.(775-777)CGA>CAA	p.R259Q		NM_152356	NP_689569	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	259	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						ATAAGCTTTCGAAGACACATG	0.408													5	46					0	0	0.000602	0	0
OR10H2	26538	broad.mit.edu	37	19	15839113	15839113	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr19:15839113C>T	uc002nbm.2	+	1	280	c.260C>T	c.(259-261)TCC>TTC	p.S87F		NM_013939	NP_039227	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H,	87	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					GACCTGCTGTCCACCCAGCGC	0.612													11	59					0	0	0.002450	0	0
CHERP	10523	broad.mit.edu	37	19	16638908	16638908	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr19:16638908G>A	uc002nei.1	-	9	1362	c.1288C>T	c.(1288-1290)CCT>TCT	p.P430S	MED26_uc002nee.2_Intron|CHERP_uc010xpg.1_5'Flank	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	430	Pro-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						TGGCCCCAAGGAGCCACGGGG	0.547													13	59					0	0	0.001368	0	0
TSHZ3	57616	broad.mit.edu	37	19	31768105	31768106	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr19:31768105_31768106GG>AA	uc002nsy.3	-	2	2658_2659	c.2593_2594CC>TT	c.(2593-2595)CCT>TTT	p.P865F		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	865					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					GATGCTGGAAGGAGTGGAGGAT	0.545													18	65					0	0	0.004672	0	0
MLL4	9757	broad.mit.edu	37	19	36223707	36223707	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr19:36223707C>T	uc010eei.2	+	29	6257	c.6257C>T	c.(6256-6258)TCG>TTG	p.S2086L		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	2086					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ACGCCTCCTTCGGGGCCAGGA	0.672													4	13					0	0	0.000602	0	0
RYR1	6261	broad.mit.edu	37	19	39013913	39013913	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr19:39013913C>T	uc002oit.2	+	69	10534	c.10404C>T	c.(10402-10404)TCC>TCT	p.S3468S	RYR1_uc002oiu.2_Silent_p.S3468S|RYR1_uc002oiv.1_Silent_p.S388S|RYR1_uc010xuf.1_Silent_p.S388S	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3468					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	ACAACATGTCCTTCCTGACTG	0.552													115	28					0	0	0.003610	0	0
MAP3K10	4294	broad.mit.edu	37	19	40715123	40715123	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr19:40715123C>T	uc002ona.2	+	6	1837	c.1549C>T	c.(1549-1551)CGC>TGC	p.R517C	MAP3K10_uc002onb.2_5'UTR	NM_002446	NP_002437	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase	517					activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			ovary(2)|lung(2)|skin(1)|pancreas(1)	6						GAGGGCCATTCGCCGTGAGTA	0.423													11	78					0	0	0.008291	0	0
CYP2A7	1549	broad.mit.edu	37	19	41383104	41383104	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr19:41383104G>A	uc002opm.2	-	7	1694	c.1152C>T	c.(1150-1152)TTC>TTT	p.F384F	CYP2A7_uc002opo.2_Silent_p.F384F|CYP2A7_uc002opn.2_Silent_p.F333F	NM_000764	NP_000755	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A,	384						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			CCTTAGGGAGGAAAAAATCCC	0.527													15	82					0	0	0.004007	0	0
PSG4	5672	broad.mit.edu	37	19	43698609	43698609	+	Missense_Mutation	SNP	C	T	T	rs150596916	by1000genomes	TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr19:43698609C>T	uc002ovy.2	-	5	1228	c.1126G>A	c.(1126-1128)GGA>AGA	p.G376R	PSG6_uc010xwk.1_Intron|PSG4_uc002owa.2_RNA|PSG4_uc002owb.2_Missense_Mutation_p.G283R|PSG4_uc002ovz.2_Missense_Mutation_p.G283R	NM_002780	NP_002771	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4 isoform	376	Ig-like C2-type 3.				defense response|female pregnancy	extracellular region				ovary(1)	1		Prostate(69;0.00682)				AGCTTTTGTCCTGATAGCTGA	0.458													160	71					0	0	0.003610	0	0
ZC3H4	23211	broad.mit.edu	37	19	47570154	47570154	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr19:47570154C>T	uc002pga.3	-	15	3409	c.3371G>A	c.(3370-3372)CGC>CAC	p.R1124H	ZC3H4_uc002pgb.1_RNA	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	1124							nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		CGCCAGCACGCGGGGGTCGTA	0.746													4	24					0	0	0.000602	0	0
FPR1	2357	broad.mit.edu	37	19	52250117	52250117	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr19:52250117T>C	uc002pxq.2	-	2	226	c.131A>G	c.(130-132)AAC>AGC	p.N44S		NM_002029	NP_002020	P21462	FPR1_HUMAN	formyl peptide receptor 1	44	Helical; Name=1; (Potential).				activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			ovary(1)|lung(1)|skin(1)	3		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	CACAAGCCCGTTGCCCAGGAC	0.532													39	13					0	0	0.006230	0	0
LILRB1	10859	broad.mit.edu	37	19	55143640	55143640	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr19:55143640C>T	uc002qgj.2	+	6	953	c.613C>T	c.(613-615)CCC>TCC	p.P205S	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Missense_Mutation_p.P205S|LILRB1_uc002qgk.2_Missense_Mutation_p.P205S|LILRB1_uc002qgm.2_Missense_Mutation_p.P205S|LILRB1_uc010erq.2_Missense_Mutation_p.P205S|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	205	Ig-like C2-type 2.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		CTCGAACTCTCCCTATGAGTG	0.607										HNSCC(37;0.09)			110	41					0	0	0.003610	0	0
NCR1	9437	broad.mit.edu	37	19	55417934	55417934	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr19:55417934G>A	uc002qib.2	+	3	162	c.124G>A	c.(124-126)GAA>AAA	p.E42K	NCR1_uc002qic.2_Missense_Mutation_p.E42K|NCR1_uc002qie.2_Missense_Mutation_p.E42K|NCR1_uc002qid.2_Intron|NCR1_uc002qif.2_Intron|NCR1_uc010esj.2_Intron	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	42	Ig-like 1.|Extracellular (Potential).				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		GGTTCCAAAGGAAAAGCAAGT	0.547													82	43					0	0	0.003610	0	0
CAD	790	broad.mit.edu	37	2	27455482	27455482	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:27455482C>T	uc002rji.2	+	18	2974	c.2812C>T	c.(2812-2814)CTT>TTT	p.L938F	CAD_uc010eyw.2_Missense_Mutation_p.L875F	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	938	CPSase B.|CPSase (Carbamoyl-phosphate synthase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	TGTCCTAGTCCTTGGCTCTGG	0.512													36	48					0	0	0.005524	0	0
FSHR	2492	broad.mit.edu	37	2	49190802	49190802	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:49190802G>A	uc002rww.2	-	10	1232	c.1158C>T	c.(1156-1158)ATC>ATT	p.I386I	FSHR_uc002rwx.2_Silent_p.I324I|FSHR_uc010fbn.2_Silent_p.I360I	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	386	Helical; Name=1; (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TGGTAGTTAGGATCACTAGCA	0.463									Gonadal_Dysgenesis_46_XX				28	33					0	0	0.006320	0	0
ASB3	51130	broad.mit.edu	37	2	53943841	53943841	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:53943841G>A	uc002rxg.1	-	6	779	c.644C>T	c.(643-645)CCC>CTC	p.P215L	ASB3_uc002rxh.1_Missense_Mutation_p.P142L|ASB3_uc002rxi.3_Missense_Mutation_p.P253L|ASB3_uc010yoo.1_Missense_Mutation_p.P132L	NM_016115	NP_057199	Q9Y575	ASB3_HUMAN	ankyrin repeat and SOCS box-containing protein 3	215	ANK 7.				intracellular signal transduction			p.D211_L216delDKATPL(1)		ovary(1)|kidney(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			AATGAACAAGGGTGTAGCTTT	0.403													23	26					0	0	0.001882	0	0
VPS54	51542	broad.mit.edu	37	2	64189210	64189210	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:64189210T>C	uc002scq.2	-	7	1155	c.992A>G	c.(991-993)CAG>CGG	p.Q331R	VPS54_uc002scp.2_Missense_Mutation_p.Q319R|VPS54_uc010fct.2_Missense_Mutation_p.Q214R	NM_016516	NP_057600	Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 isoform 1	331					protein transport|retrograde transport, endosome to Golgi						0						GTGAATGCCCTGAAGTTCCTG	0.358													48	81					0	0	0.003610	0	0
FBXO48	554251	broad.mit.edu	37	2	68692015	68692015	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:68692015C>T	uc002seo.2	-	3	671	c.263G>A	c.(262-264)CGA>CAA	p.R88Q	APLF_uc010fdf.2_5'Flank|APLF_uc002sep.2_5'Flank	NM_001024680	NP_001019851	Q5FWF7	FBX48_HUMAN	F-box protein 48	88											0						TATTTCTCTTCGGCACACAGC	0.433													17	94					0	0	0.001523	0	0
ALMS1	7840	broad.mit.edu	37	2	73717740	73717740	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:73717740G>C	uc002sje.1	+	12	8768	c.8657G>C	c.(8656-8658)CGA>CCA	p.R2886P	ALMS1_uc002sjf.1_Missense_Mutation_p.R2842P|ALMS1_uc002sjg.2_Missense_Mutation_p.R2272P|ALMS1_uc002sjh.1_Missense_Mutation_p.R2272P	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2884					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						CTTGAACAACGAGAGCTCTTT	0.438													41	69					0	0	0.002522	0	0
MOGS	7841	broad.mit.edu	37	2	74688900	74688900	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:74688900G>A	uc010ffj.2	-	4	2179	c.2016C>T	c.(2014-2016)CTC>CTT	p.L672L	MOGS_uc010ffh.2_Silent_p.L397L|MOGS_uc010yrt.1_Silent_p.L553L|MOGS_uc010ffi.2_Silent_p.L566L	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	672	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						CCACCCGAACGAGCCCCTGAG	0.587													37	61					0	0	0.006999	0	0
MAT2A	4144	broad.mit.edu	37	2	85769831	85769831	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:85769831C>T	uc002spr.2	+	7	1035	c.912C>T	c.(910-912)TCC>TCT	p.S304S	MAT2A_uc010ysr.1_Silent_p.S304S|MAT2A_uc010fgk.2_Silent_p.S278S|MAT2A_uc010fgl.2_Silent_p.S241S	NM_005911	NP_005902	P31153	METK2_HUMAN	methionine adenosyltransferase II, alpha	304					methylation|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity				0					L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	TGGCAAAATCCCTTGTTAAAG	0.468													27	22					0	0	0.005443	0	0
SFTPB	6439	broad.mit.edu	37	2	85892780	85892780	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:85892780G>A	uc002sqh.2	-	5	537	c.531C>T	c.(529-531)GTC>GTT	p.V177V	SFTPB_uc002sqi.2_Silent_p.V189V|SFTPB_uc002sqj.2_Silent_p.V177V	NM_198843	NP_942140	P07988	PSPB_HUMAN	surfactant, pulmonary-associated protein B	177					organ morphogenesis|respiratory gaseous exchange|sphingolipid metabolic process	extracellular space|lysosome				ovary(1)|central_nervous_system(1)	2						GCACAGGGAGGACGAGCTTGT	0.667													41	48					0	0	0.003610	0	0
RMND5A	64795	broad.mit.edu	37	2	86979038	86979038	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:86979038G>C	uc010ytm.1	+	3	682	c.305G>C	c.(304-306)AGC>ACC	p.S102T	RMND5A_uc002srs.3_Intron|RMND5A_uc002srr.2_Missense_Mutation_p.S102T	NM_022780	NP_073617	Q9H871	RMD5A_HUMAN	required for meiotic nuclear division 5 homolog	102										ovary(1)|skin(1)	2						TCTGACATTAGCAGTGTGGGA	0.428													14	19					0	0	0.003163	0	0
SLC9A2	6549	broad.mit.edu	37	2	103300682	103300682	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:103300682C>T	uc002tca.2	+	5	1454	c.1312C>T	c.(1312-1314)CGA>TGA	p.R438*		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	438						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						TGGAGGACTTCGAGGTGCCAT	0.438													53	51					0	0	0.003610	0	0
C2orf49	79074	broad.mit.edu	37	2	105959566	105959566	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:105959566C>T	uc002tcs.1	+	3	560	c.528C>T	c.(526-528)GAC>GAT	p.D176D	C2orf49_uc010fjd.1_Silent_p.D134D	NM_024093	NP_076998	Q9BVC5	ASHWN_HUMAN	ashwin	176						tRNA-splicing ligase complex					0						AGAACCATGACTTAACGCATA	0.428													28	23					0	0	0.006320	0	0
RGPD4	285190	broad.mit.edu	37	2	108487225	108487225	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:108487225G>A	uc010ywk.1	+	20	2847	c.2765G>A	c.(2764-2766)GGA>GAA	p.G922E	RGPD4_uc002tdu.2_Missense_Mutation_p.G109E|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	922					intracellular transport		binding			skin(2)	2						TCTGCTGATGGATTTAAATTT	0.388													78	97					0	0	0.003610	0	0
RGPD4	285190	broad.mit.edu	37	2	108488139	108488139	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:108488139G>A	uc010ywk.1	+	20	3761	c.3679G>A	c.(3679-3681)GGT>AGT	p.G1227S	RGPD4_uc002tdu.2_Missense_Mutation_p.G414S|RGPD4_uc010ywl.1_Intron	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1227					intracellular transport		binding			skin(2)	2						TTCAGGTACAGGTGCGGCCGG	0.413													84	99					0	0	0.003610	0	0
CKAP2L	150468	broad.mit.edu	37	2	113496483	113496484	+	Missense_Mutation	DNP	CT	TC	TC			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:113496483_113496484CT>TC	uc002tie.2	-	9	2233_2234	c.2154_2155AG>GA	c.(2152-2157)TTAGAA>TTGAAA	p.E719K	CKAP2L_uc002tif.2_Missense_Mutation_p.E308K|CKAP2L_uc010yxp.1_Missense_Mutation_p.E554K|uc002tid.2_Intron	NM_152515	NP_689728	Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	719						centrosome					0						TCTTCCACTTCTAACAGTTCAT	0.441													49	84					0	0	0.004672	0	0
POTEF	728378	broad.mit.edu	37	2	130832585	130832585	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:130832585G>A	uc010fmh.2	-	17	2860	c.2460C>T	c.(2458-2460)ACC>ACT	p.T820T		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	820	Actin-like.					cell cortex	ATP binding			skin(3)|ovary(2)	5						ACATGATCTGGGTCATCTTCT	0.597													72	64					0	0	0.003610	0	0
GALNT5	11227	broad.mit.edu	37	2	158115636	158115636	+	Missense_Mutation	SNP	C	T	T	rs144689586		TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:158115636C>T	uc002tzg.2	+	1	1297	c.1042C>T	c.(1042-1044)CCT>TCT	p.P348S	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	348	Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.P348S(1)		breast(3)|skin(1)	4						AACAATATTTCCTAAAGTATT	0.393													40	40					0	0	0.007835	0	0
UPP2	151531	broad.mit.edu	37	2	158977948	158977948	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:158977948C>T	uc002tzp.2	+	5	676	c.482C>T	c.(481-483)ACG>ATG	p.T161M	UPP2_uc002tzo.2_Missense_Mutation_p.T218M	NM_173355	NP_775491	O95045	UPP2_HUMAN	uridine phosphorylase 2 isoform a	161					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity				0						GTTGTAATAACGGATATAGCT	0.393													74	134					0	0	0.003610	0	0
BAZ2B	29994	broad.mit.edu	37	2	160241774	160241774	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:160241774A>G	uc002uao.2	-	23	3930	c.3578T>C	c.(3577-3579)CTT>CCT	p.L1193P	BAZ2B_uc002uap.2_Missense_Mutation_p.L1157P	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1193					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						ACTTTCAGTAAGCTCAGTTTG	0.443													32	57					0	0	0.002096	0	0
SCN9A	6335	broad.mit.edu	37	2	167055770	167055770	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:167055770C>T	uc010fpl.2	-	27	5687	c.5346G>A	c.(5344-5346)GCG>GCA	p.A1782A	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1793						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TAAACTGGGTCGCATCGGGAT	0.448													45	59					0	0	0.003214	0	0
TTN	7273	broad.mit.edu	37	2	179396515	179396515	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:179396515G>A	uc010zfg.1	-	307	97347	c.97123C>T	c.(97123-97125)CGA>TGA	p.R32375*	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Nonsense_Mutation_p.R26070*|TTN_uc010zfi.1_Nonsense_Mutation_p.R26003*|TTN_uc010zfj.1_Nonsense_Mutation_p.R25878*|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33302							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTGTGATTCGAGGGGCATGG	0.438													29	41					0	0	0.007291	0	0
TTN	7273	broad.mit.edu	37	2	179444752	179444752	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:179444752C>T	uc010zfg.1	-	267	59782	c.59558G>A	c.(59557-59559)GGA>GAA	p.G19853E	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G13548E|TTN_uc010zfi.1_Missense_Mutation_p.G13481E|TTN_uc010zfj.1_Missense_Mutation_p.G13356E|uc002umv.1_3'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20780							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTAGGATTTTCCCTCCTCCAA	0.443													45	83					0	0	0.002852	0	0
TTN	7273	broad.mit.edu	37	2	179454707	179454707	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:179454707G>A	uc010zfg.1	-	253	54265	c.54041C>T	c.(54040-54042)ACC>ATC	p.T18014I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.T11709I|TTN_uc010zfi.1_Missense_Mutation_p.T11642I|TTN_uc010zfj.1_Missense_Mutation_p.T11517I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18941							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTCTCTTTGGTTACATTGGT	0.433													25	30					0	0	0.003954	0	0
TTN	7273	broad.mit.edu	37	2	179475004	179475004	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:179475004G>A	uc010zfg.1	-	220	43769	c.43545C>T	c.(43543-43545)GTC>GTT	p.V14515V	uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.V8210V|TTN_uc010zfi.1_Silent_p.V8143V|TTN_uc010zfj.1_Silent_p.V8018V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15442							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCGCTCCAGGACATAATGAA	0.418													77	109					0	0	0.003610	0	0
TTN	7273	broad.mit.edu	37	2	179604775	179604775	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:179604775C>T	uc010zfh.1	-	46	12896	c.12672G>A	c.(12670-12672)CTG>CTA	p.L4224L	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Silent_p.L4157L|TTN_uc010zfj.1_Silent_p.L4032L|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	4152							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGAATTTTCAGGTTTAATC	0.488													35	34					0	0	0.003271	0	0
TTN	7273	broad.mit.edu	37	2	179635022	179635022	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:179635022C>T	uc010zfg.1	-	36	8630	c.8406G>A	c.(8404-8406)AAG>AAA	p.K2802K	TTN_uc010zfh.1_Silent_p.K2756K|TTN_uc010zfi.1_Silent_p.K2756K|TTN_uc010zfj.1_Silent_p.K2756K|TTN_uc002unb.2_Silent_p.K2802K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2802							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGTCACATCCTTTGGCTTTT	0.403													34	65					0	0	0.004289	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801739	185801739	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:185801739G>A	uc002uph.2	+	4	2210	c.1616G>A	c.(1615-1617)GGA>GAA	p.G539E		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	539						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TGTGATTCTGGAAAAAATGAG	0.343													21	26					0	0	0.001523	0	0
COL3A1	1281	broad.mit.edu	37	2	189850417	189850417	+	Silent	SNP	T	C	C			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:189850417T>C	uc002uqj.1	+	4	477	c.360T>C	c.(358-360)AAT>AAC	p.N120N		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	120					axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CTGGGAGAAATGGTGACCCTG	0.438													22	27					0	0	0.001523	0	0
OBSL1	23363	broad.mit.edu	37	2	220424197	220424197	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:220424197G>A	uc010fwk.2	-	9	3033	c.2976C>T	c.(2974-2976)TAC>TAT	p.Y992Y	OBSL1_uc002vmh.1_5'UTR|OBSL1_uc010zli.1_5'UTR|OBSL1_uc010fwl.1_Silent_p.Y467Y	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	992	Ig-like 8.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CATCGCGAGGGTATATGATCC	0.592											OREG0003986	type=REGULATORY REGION|Gene=OBSL1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	38	55					0	0	0.007835	0	0
UGT1A5	54579	broad.mit.edu	37	2	234681148	234681148	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr2:234681148G>A	uc002vuw.2	+	5	1548	c.1548G>A	c.(1546-1548)CGG>CGA	p.R516R	UGT1A8_uc002vup.2_Silent_p.R512R|UGT1A10_uc002vur.2_Silent_p.R512R|UGT1A9_uc002vus.2_Silent_p.R512R|UGT1A7_uc002vut.2_Silent_p.R512R|UGT1A6_uc002vuu.2_Silent_p.R247R|UGT1A6_uc002vuv.3_Silent_p.R514R|UGT1A4_uc002vux.2_Silent_p.R516R|UGT1A3_uc002vuy.2_Silent_p.R516R|UGT1A9_uc002vva.2_RNA|UGT1A1_uc002vvb.2_Silent_p.R515R	NM_019078	NP_061951	P35504	UD15_HUMAN	UDP glycosyltransferase 1 family, polypeptide A5	516					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		ATGGCTACCGGAAATGCTTGG	0.468													26	23					0	0	0.004656	0	0
ZCCHC3	85364	broad.mit.edu	37	20	279331	279331	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr20:279331G>A	uc002wdf.2	+	2	1125	c.1101G>A	c.(1099-1101)CGG>CGA	p.R367R	ZCCHC3_uc002wdg.2_RNA	NM_033089	NP_149080	Q9NUD5	ZCHC3_HUMAN	zinc finger, CCHC domain containing 3	368	CCHC-type 2.						nucleic acid binding|zinc ion binding				0		all_cancers(10;0.000209)|Lung NSC(37;0.0417)|all_lung(30;0.0713)|all_epithelial(17;0.0748)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			CTTACTGCCGGAAGGGCATCG	0.617													48	42					0	0	0.003610	0	0
PLCB4	5332	broad.mit.edu	37	20	9417698	9417698	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr20:9417698G>A	uc002wnf.2	+	28	2763	c.2627G>A	c.(2626-2628)GGA>GAA	p.G876E	PLCB4_uc010gbw.1_Missense_Mutation_p.G876E|PLCB4_uc010gbx.2_Missense_Mutation_p.G888E|PLCB4_uc002wne.2_Missense_Mutation_p.G876E|PLCB4_uc002wnh.2_Missense_Mutation_p.G723E	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	876					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						GACAAGAAAGGAAAGGCCAAC	0.498													12	24					0	0	0.001368	0	0
NINL	22981	broad.mit.edu	37	20	25439082	25439082	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr20:25439082G>A	uc002wux.1	-	22	3854	c.3780C>T	c.(3778-3780)GCC>GCT	p.A1260A	NINL_uc010gdn.1_Silent_p.A911A|NINL_uc002wuw.1_Silent_p.A51A	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	1260	Potential.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						GATGCAGCTCGGCCACACGGT	0.672													35	28					0	0	0.002836	0	0
GSS	2937	broad.mit.edu	37	20	33539633	33539633	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr20:33539633A>G	uc002xbg.2	-	2	103	c.23T>C	c.(22-24)CTC>CCC	p.L8P	GSS_uc010zuo.1_Missense_Mutation_p.L8P|GSS_uc010zup.1_5'UTR|GSS_uc002xbh.2_RNA|GSS_uc010gez.1_5'UTR	NM_000178	NP_000169	P48637	GSHB_HUMAN	glutathione synthetase	8					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	ATCCTGCAAGAGGCTCCCCCA	0.597													17	27					0	0	0.004990	0	0
C20orf132	140699	broad.mit.edu	37	20	35769577	35769577	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr20:35769577G>A	uc010zvu.1	-	14	1597	c.1506C>T	c.(1504-1506)TCC>TCT	p.S502S	C20orf132_uc002xgk.2_Intron|C20orf132_uc002xgm.2_Silent_p.S502S|C20orf132_uc002xgn.2_Silent_p.S467S	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1	377											0		Myeloproliferative disorder(115;0.00878)				TCTCAAATTGGGACTCTGTAT	0.418													17	26					0	0	0.004990	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37524229	37524229	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr20:37524229G>A	uc002xje.2	+	4	532	c.343G>A	c.(343-345)GAA>AAA	p.E115K	PPP1R16B_uc010ggc.2_Missense_Mutation_p.E115K	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	115	ANK 1.				regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				CAACTTTGAGGAAATTGTGAA	0.602													19	30					0	0	0.008871	0	0
PTPRT	11122	broad.mit.edu	37	20	40827885	40827886	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr20:40827885_40827886CC>TT	uc002xkg.2	-	16	2669_2670	c.2485_2486GG>AA	c.(2485-2487)GGA>AAA	p.G829K	PTPRT_uc010ggj.2_Missense_Mutation_p.G848K|PTPRT_uc010ggi.2_Missense_Mutation_p.G32K	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	829	Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CTTACTGAATCCGTTGACGTCC	0.564													231	340					0	0	0.004672	0	0
L3MBTL	26013	broad.mit.edu	37	20	42158988	42158988	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr20:42158988A>G	uc010zwh.1	+	10	1101	c.1055A>G	c.(1054-1056)AAT>AGT	p.N352S	L3MBTL_uc002xkl.2_Missense_Mutation_p.N284S|L3MBTL_uc002xkm.2_Missense_Mutation_p.N284S|L3MBTL_uc010ggl.2_Missense_Mutation_p.N284S|L3MBTL_uc002xkn.1_Missense_Mutation_p.N43S|L3MBTL_uc002xko.2_5'Flank	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	284	MBT 1.				chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			TTCTGGGTCAATGCCAACTCC	0.557													66	81					0	0	0.003610	0	0
SLC12A5	57468	broad.mit.edu	37	20	44666019	44666019	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr20:44666019C>T	uc010zxl.1	+	6	752	c.676C>T	c.(676-678)CTG>TTG	p.L226L	SLC12A5_uc002xra.2_Silent_p.L203L|SLC12A5_uc010zxm.1_Intron|SLC12A5_uc002xrb.2_Silent_p.L203L	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	226	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CATCGAAATCCTGCTGGTAAG	0.433													18	25					0	0	0.006122	0	0
ATP9A	10079	broad.mit.edu	37	20	50286579	50286579	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr20:50286579G>A	uc002xwg.1	-	13	1250	c.1250C>T	c.(1249-1251)TCA>TTA	p.S417L	ATP9A_uc010gih.1_Missense_Mutation_p.S281L|ATP9A_uc002xwf.1_Intron	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	417	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						TTCGTCCATTGAGTCGAGGCC	0.423													52	73					0	0	0.003610	0	0
ZNF831	128611	broad.mit.edu	37	20	57767335	57767335	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr20:57767335G>A	uc002yan.2	+	1	1261	c.1261G>A	c.(1261-1263)GAT>AAT	p.D421N		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	421	Potential.					intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GGTGGTGGACGATGCCCAGCT	0.587													13	16					0	0	0.001368	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28304486	28304486	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr21:28304486C>T	uc002ymg.2	-	6	2615	c.1886G>A	c.(1885-1887)CGT>CAT	p.R629H		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	629	Cys-rich.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						CTGTTCATGACGAAATGATTT	0.373													12	66					0	0	0.004007	0	0
RNF160	26046	broad.mit.edu	37	21	30339415	30339415	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr21:30339415G>A	uc002ymr.2	-	10	1549	c.1536C>T	c.(1534-1536)TCC>TCT	p.S512S	RNF160_uc010gll.1_RNA	NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	466							ligase activity|zinc ion binding				0						TGGCTTCCCAGGAACTTAGAG	0.413													39	88					0	0	0.004878	0	0
DSCAM	1826	broad.mit.edu	37	21	41447075	41447075	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr21:41447075G>A	uc002yyq.1	-	27	5229	c.4777C>T	c.(4777-4779)CTC>TTC	p.L1593F	DSCAM_uc002yyr.1_Intron	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1593	Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AGCATCTTGAGCCCCTCGTTG	0.542													27	22					0	0	0.006320	0	0
DSCAM	1826	broad.mit.edu	37	21	41450723	41450723	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr21:41450723G>A	uc002yyq.1	-	26	5054	c.4602C>T	c.(4600-4602)ATC>ATT	p.I1534I	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1534	Extracellular (Potential).|Fibronectin type-III 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GGTCATACAGGATGTAGGACT	0.582													29	26					0	0	0.001786	0	0
DSCAM	1826	broad.mit.edu	37	21	41550861	41550861	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr21:41550861G>A	uc002yyq.1	-	15	3392	c.2940C>T	c.(2938-2940)GAC>GAT	p.D980D	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	980	Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TACCTGCCTCGTCCGCCGTGA	0.587													37	22					0	0	0.005524	0	0
DSCAM	1826	broad.mit.edu	37	21	41725626	41725626	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr21:41725626G>A	uc002yyq.1	-	5	1152	c.700C>T	c.(700-702)CGC>TGC	p.R234C	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	234	Extracellular (Potential).|Ig-like C2-type 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				ATGGCTTTGCGATGGTCAAAC	0.537													21	17					0	0	0.002299	0	0
C22orf9	23313	broad.mit.edu	37	22	45593791	45593792	+	Silent	DNP	GG	AA	AA			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr22:45593791_45593792GG>AA	uc003bfx.1	-	9	1119_1120	c.1053_1054CC>TT	c.(1051-1056)TCCCTG>TCTTTG	p.351_352SL>SL	C22orf9_uc010gzw.1_Silent_p.203_204SL>SL|C22orf9_uc003bfv.1_Silent_p.360_361SL>SL|C22orf9_uc003bfw.1_Silent_p.356_357SL>SL|C22orf9_uc010gzx.2_Silent_p.333_334SL>SL	NM_001009880	NP_001009880	Q6ICG6	K0930_HUMAN	hypothetical protein LOC23313 isoform b	351_352							protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|READ - Rectum adenocarcinoma(1;0.000617)|Colorectal(1;0.0024)		GTGCCCGACAGGGACCGAGACC	0.609													23	82					0	0	0.004672	0	0
GRM7	2917	broad.mit.edu	37	3	7494494	7494494	+	Missense_Mutation	SNP	G	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr3:7494494G>T	uc003bqm.2	+	6	1649	c.1375G>T	c.(1375-1377)GGT>TGT	p.G459C	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.G459C|GRM7_uc003bql.2_Missense_Mutation_p.G459C|GRM7_uc003bqn.1_Missense_Mutation_p.G42C|GRM7_uc010hch.1_5'UTR	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	459	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	TAATTTCAATGGTGAGTCTCC	0.383													21	2					7.45023e-12	1.22843e-11	0.001523	1	0
CSPG5	10675	broad.mit.edu	37	3	47618694	47618694	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr3:47618694G>A	uc003crp.3	-	2	998	c.822C>T	c.(820-822)GAC>GAT	p.D274D	CSPG5_uc003crn.2_Silent_p.D136D|CSPG5_uc003cro.3_Silent_p.D274D|CSPG5_uc011bbb.1_Silent_p.D136D	NM_006574	NP_006565	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan	274	Interaction with TNC and TNR (By similarity).|Extracellular (Potential).				cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		cttcatccAAGTCATCATAAA	0.353													11	1					0	0	0.000978	0	0
COL7A1	1294	broad.mit.edu	37	3	48622503	48622503	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr3:48622503C>T	uc003ctz.2	-	32	3942	c.3941G>A	c.(3940-3942)GGG>GAG	p.G1314E		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1314	Triple-helical region.|Interrupted collagenous region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CCCAGGATTCCCGGCGCGGCC	0.682													42	9					0	0	0.003610	0	0
COL7A1	1294	broad.mit.edu	37	3	48626838	48626838	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr3:48626838C>G	uc003ctz.2	-	17	2237	c.2236G>C	c.(2236-2238)GAT>CAT	p.D746H		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	746	Nonhelical region (NC1).|Fibronectin type-III 6.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TACTCAGTATCTGGCTCCAGT	0.622													6	51					0	0	0.001984	0	0
CISH	1154	broad.mit.edu	37	3	50645938	50645938	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr3:50645938G>A	uc003dax.2	-	2	288	c.107C>T	c.(106-108)CCC>CTC	p.P36L	CISH_uc010hlq.2_Missense_Mutation_p.P53L	NM_145071	NP_659508	Q9NSE2	CISH_HUMAN	cytokine-inducible SH2-containing protein	36					intracellular signal transduction|negative regulation of signal transduction|regulation of cell growth	intracellular					0				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		AGCAGGCAAGGGCTGCATGAC	0.657													26	5					0	0	0.004656	0	0
DNAH12	201625	broad.mit.edu	37	3	57509322	57509322	+	Missense_Mutation	SNP	C	T	T	rs34762664		TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr3:57509322C>T	uc003dit.2	-	4	448	c.267G>A	c.(265-267)ATG>ATA	p.M89I	DNAH12_uc003diu.2_Missense_Mutation_p.M89I	NM_178504	NP_848599	Q6ZR08	DYH12_HUMAN	dynein heavy chain domain 2 isoform 1	89	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			pancreas(1)|skin(1)	2						CTTTTTTTTTCATTTCACTGG	0.239													25	3					0	0	0.002096	0	0
GXYLT2	727936	broad.mit.edu	37	3	73024140	73024140	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr3:73024140G>A	uc003dpg.2	+	7	1162	c.1162G>A	c.(1162-1164)GAC>AAC	p.D388N		NM_001080393	NP_001073862	A0PJZ3	GXLT2_HUMAN	glycosyltransferase 8 domain containing 4	388	Lumenal (Potential).				O-glycan processing	integral to membrane	UDP-xylosyltransferase activity				0						TCCCTTTCAAGACAATCTCTT	0.348													79	32					0	0	0.003610	0	0
CEP97	79598	broad.mit.edu	37	3	101483760	101483760	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr3:101483760C>T	uc003dvk.1	+	11	1990	c.1963C>T	c.(1963-1965)CCT>TCT	p.P655S	CEP97_uc011bhf.1_Missense_Mutation_p.P596S|CEP97_uc003dvl.1_Missense_Mutation_p.P377S|CEP97_uc003dvm.1_Missense_Mutation_p.P493S	NM_024548	NP_078824	Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	655	CEP110 binding.					centrosome|nucleus	protein binding			ovary(2)	2						TGATGTTCCTCCTATATCAAG	0.408													58	11					0	0	0.003610	0	0
KIAA1407	57577	broad.mit.edu	37	3	113753789	113753789	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr3:113753789C>T	uc003eax.2	-	6	948	c.801G>A	c.(799-801)GTG>GTA	p.V267V	KIAA1407_uc011bin.1_RNA|KIAA1407_uc011bio.1_Silent_p.V245V|KIAA1407_uc011bip.1_Silent_p.V254V	NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	267	Potential.									ovary(2)	2						ATGCTGCTTTCACAGTGCGTC	0.448													110	24					0	0	0.003610	0	0
DBR1	51163	broad.mit.edu	37	3	137888984	137888984	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr3:137888984G>A	uc003erv.2	-	4	590	c.454C>T	c.(454-456)CAT>TAT	p.H152Y	DBR1_uc003eru.2_Missense_Mutation_p.H101Y	NM_016216	NP_057300	Q9UK59	DBR1_HUMAN	debranching enzyme homolog 1	152						nucleus	metal ion binding|RNA lariat debranching enzyme activity				0						TTTCTCACATGATATATACTC	0.303													183	37					0	0	0.003610	0	0
CLSTN2	64084	broad.mit.edu	37	3	140123409	140123409	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr3:140123409C>T	uc003etn.2	+	4	628	c.438C>T	c.(436-438)GTC>GTT	p.V146V	CLSTN2_uc003etm.2_Silent_p.V146V	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	146	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						GGGCCGTGGTCCATATACAGG	0.537										HNSCC(16;0.037)			51	5					0	0	0.003610	0	0
SR140	23350	broad.mit.edu	37	3	142769880	142769880	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr3:142769880C>T	uc003evh.1	+	25	2743	c.2644C>T	c.(2644-2646)CTT>TTT	p.L882F	SR140_uc003evi.1_Missense_Mutation_p.L473F|SR140_uc003evj.1_RNA|SR140_uc003evk.1_Missense_Mutation_p.L881F|SR140_uc003evl.1_Missense_Mutation_p.L449F	NM_001080415	NP_001073884	O15042	SR140_HUMAN	U2-associated SR140 protein	882	Potential.|Glu-rich.				RNA processing	nucleus	nucleotide binding|RNA binding				0						CAGAGATAAACTTCTTCAACG	0.338													17	4					0	0	0.004990	0	0
MED12L	116931	broad.mit.edu	37	3	151129185	151129185	+	Silent	SNP	A	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr3:151129185A>T	uc003eyp.2	+	39	5963	c.5925A>T	c.(5923-5925)GCA>GCT	p.A1975A	MED12L_uc011bnz.1_Intron	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1975	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATCCGGCCGCACATTCCAACC	0.577													105	6					0	0	0.003610	0	0
ACOX3	8310	broad.mit.edu	37	4	8383290	8383290	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr4:8383290C>T	uc010idk.2	-	14	1727	c.1582G>A	c.(1582-1584)GAG>AAG	p.E528K	ACOX3_uc003glc.3_Missense_Mutation_p.E528K|ACOX3_uc003gld.3_Missense_Mutation_p.E528K|ACOX3_uc003gle.1_Missense_Mutation_p.E433K	NM_003501	NP_003492	O15254	ACOX3_HUMAN	acyl-Coenzyme A oxidase 3 isoform a	528					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			central_nervous_system(1)	1						TGATAAGTCTCTCGGAGCAGG	0.403													40	26					0	0	0.007835	0	0
LDB2	9079	broad.mit.edu	37	4	16760851	16760851	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr4:16760851G>A	uc003goz.2	-	2	481	c.165C>T	c.(163-165)GCC>GCT	p.A55A	LDB2_uc003gpa.2_Silent_p.A55A|LDB2_uc003gpb.2_Silent_p.A55A|LDB2_uc011bxh.1_Silent_p.A55A|LDB2_uc010iee.2_Silent_p.A55A	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	55							LIM domain binding|transcription cofactor activity				0						AAAATTCAGTGGCAAAGGCGT	0.373													22	26					0	0	0.002780	0	0
UGT2B10	7365	broad.mit.edu	37	4	69696575	69696575	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr4:69696575G>A	uc003hee.2	+	6	1590	c.1565G>A	c.(1564-1566)GGA>GAA	p.G522E	UGT2B10_uc011cam.1_Missense_Mutation_p.G438E	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	522					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						GCTAGAAAAGGAAAGAAGGGA	0.383													45	28					0	0	0.003214	0	0
UGT2B4	7363	broad.mit.edu	37	4	70352395	70352395	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr4:70352395C>T	uc003hek.3	-	4	1069	c.1022G>A	c.(1021-1023)GGG>GAG	p.G341E	UGT2B4_uc011cap.1_Missense_Mutation_p.G205E|UGT2B4_uc003hel.3_Missense_Mutation_p.G341E	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	341					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						TGGTTTATTCCCATCAAATCT	0.348													59	45					0	0	0.003610	0	0
GPRIN3	285513	broad.mit.edu	37	4	90170412	90170412	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr4:90170412C>T	uc003hsm.1	-	2	1369	c.850G>A	c.(850-852)GTG>ATG	p.V284M		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	284										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		GGCAGCGGCACCTTCTCTGGA	0.567													26	101					0	0	0.006320	0	0
GRID2	2895	broad.mit.edu	37	4	94128596	94128596	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr4:94128596C>T	uc011cdt.1	+	5	1035	c.777C>T	c.(775-777)ATC>ATT	p.I259I	GRID2_uc010ikx.2_Silent_p.I259I|GRID2_uc011cdu.1_Silent_p.I164I|GRID2_uc011cdv.1_RNA|GRID2_uc010ikz.1_5'UTR	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	259	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	GTCACTGGATCATTATAAATG	0.279													12	70					0	0	0.001368	0	0
ANK2	287	broad.mit.edu	37	4	114294463	114294463	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr4:114294463G>A	uc003ibe.3	+	45	11817	c.11717G>A	c.(11716-11718)CGG>CAG	p.R3906Q	ANK2_uc003ibd.3_Missense_Mutation_p.R1812Q|ANK2_uc003ibf.3_Missense_Mutation_p.R1821Q|ANK2_uc011cgc.1_Missense_Mutation_p.R997Q|ANK2_uc003ibg.3_Missense_Mutation_p.R836Q|ANK2_uc003ibh.3_Missense_Mutation_p.R526Q|ANK2_uc011cgd.1_Missense_Mutation_p.R1208Q|ANK2_uc010imr.2_5'UTR|ANK2_uc010ims.2_5'UTR	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3873			R -> W (in LQT4; loss of function).		axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding	p.R3906Q(1)		central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ATCATTAGGCGGTATGTATCC	0.388													10	49					0	0	0.008291	0	0
SYNPO2	171024	broad.mit.edu	37	4	119951551	119951551	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr4:119951551G>A	uc003icm.3	+	4	1817	c.1621G>A	c.(1621-1623)GAA>AAA	p.E541K	SYNPO2_uc010ina.2_Missense_Mutation_p.E541K|SYNPO2_uc010inb.2_Missense_Mutation_p.E541K|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Missense_Mutation_p.E469K	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	541						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						AAGAAAGGAGGAAGAGTCGGT	0.512													42	17					0	0	0.007835	0	0
CLGN	1047	broad.mit.edu	37	4	141315179	141315179	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr4:141315179C>T	uc011chi.1	-	12	1384	c.1166G>A	c.(1165-1167)CGA>CAA	p.R389Q	CLGN_uc003iii.2_Missense_Mutation_p.R389Q	NM_001130675	NP_001124147	O14967	CLGN_HUMAN	calmegin precursor	389	Lumenal (Potential).|2-4.				protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			ovary(2)|skin(1)	3	all_hematologic(180;0.162)					AGGAATTTTTCGAGGACTCCA	0.343													9	28					0	0	0.008291	0	0
UCP1	7350	broad.mit.edu	37	4	141484552	141484552	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr4:141484552C>T	uc011chj.1	-	3	522	c.446G>A	c.(445-447)GGA>GAA	p.G149E	UCP1_uc011chk.1_Missense_Mutation_p.G148E	NM_021833	NP_068605	P25874	UCP1_HUMAN	uncoupling protein 1	149	Solcar 2.				brown fat cell differentiation|cellular lipid metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	binding			ovary(1)	1	all_hematologic(180;0.162)					AGGTTTGATTCCGTGGAGATG	0.468													18	63					0	0	0.008871	0	0
RXFP1	59350	broad.mit.edu	37	4	159533492	159533492	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr4:159533492G>A	uc003ipz.2	+	8	740	c.658G>A	c.(658-660)GGA>AGA	p.G220R	RXFP1_uc010iqj.1_Missense_Mutation_p.G49R|RXFP1_uc011cja.1_Missense_Mutation_p.G139R|RXFP1_uc010iqo.2_Missense_Mutation_p.G220R|RXFP1_uc011cjb.1_Missense_Mutation_p.G166R|RXFP1_uc010iqk.2_Missense_Mutation_p.G88R|RXFP1_uc011cjc.1_Missense_Mutation_p.G139R|RXFP1_uc011cjd.1_Missense_Mutation_p.G139R|RXFP1_uc010iql.2_Missense_Mutation_p.G88R|RXFP1_uc011cje.1_Missense_Mutation_p.G247R|RXFP1_uc010iqm.2_Missense_Mutation_p.G187R|RXFP1_uc011cjf.1_Missense_Mutation_p.G90R|RXFP1_uc010iqn.2_Missense_Mutation_p.G166R	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	220	LRR 3.|Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		AACATTTTATGGACTAAATTC	0.274													4	22					0	0	0.000602	0	0
FAT1	2195	broad.mit.edu	37	4	187557862	187557862	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr4:187557862G>A	uc003izf.2	-	5	4037	c.3849C>T	c.(3847-3849)CCC>CCT	p.P1283P		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1283	Extracellular (Potential).|Cadherin 11.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TTTCTGCATTGGGGCCCTCAT	0.507										HNSCC(5;0.00058)			150	92					0	0	0.003610	0	0
SLC6A3	6531	broad.mit.edu	37	5	1403158	1403158	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:1403158C>T	uc003jck.2	-	13	1767	c.1646G>A	c.(1645-1647)GGA>GAA	p.G549E		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	549					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	GATGTAGGCTCCGTAGTGGGG	0.622													15	19					0	0	0.004007	0	0
CAPSL	133690	broad.mit.edu	37	5	35921135	35921135	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:35921135G>A	uc003jjt.1	-	2	183	c.88C>T	c.(88-90)CGA>TGA	p.R30*	CAPSL_uc003jju.1_Nonsense_Mutation_p.R30*	NM_001042625	NP_001036090	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	30						cytoplasm	calcium ion binding			skin(1)	1	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			CACTGCAGTCGGAGTCTTTCA	0.592													22	36					0	0	0.001523	0	0
UGT3A1	133688	broad.mit.edu	37	5	35955882	35955882	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:35955882C>T	uc003jjv.1	-	6	1317	c.1160G>A	c.(1159-1161)GGA>GAA	p.G387E	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Missense_Mutation_p.G387E|UGT3A1_uc011cor.1_Missense_Mutation_p.G353E	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	387	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GACTGGTAATCCCACCATGGG	0.507													31	62					0	0	0.002836	0	0
ZNF131	7690	broad.mit.edu	37	5	43174852	43174852	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:43174852C>A	uc011cpw.1	+	7	1525	c.1489C>A	c.(1489-1491)CAA>AAA	p.Q497K	ZNF131_uc003jnj.3_Missense_Mutation_p.Q218K|ZNF131_uc003jnk.2_Missense_Mutation_p.Q463K|ZNF131_uc003jnn.3_Missense_Mutation_p.Q218K|ZNF131_uc003jnl.1_Intron|ZNF131_uc010ivm.1_Intron	NM_003432	NP_003423	P52739	ZN131_HUMAN	zinc finger protein 131	497						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GACTGTGGAACAAGTCCATCC	0.478													9	31					3.09899e-07	5.03294e-07	0.004482	1	0
ANKRD55	79722	broad.mit.edu	37	5	55407474	55407474	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:55407474C>T	uc003jqu.2	-	10	1253	c.1101G>A	c.(1099-1101)AGG>AGA	p.R367R	ANKRD55_uc003jqt.2_Silent_p.R79R	NM_024669	NP_078945	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55 isoform 1	366										skin(1)	1		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				TGTATCGGTCCCTGCTGGGAT	0.507													86	124					0	0	0.003610	0	0
GPR98	84059	broad.mit.edu	37	5	89924572	89924572	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:89924572G>A	uc003kju.2	+	8	1528	c.1432G>A	c.(1432-1434)GAA>AAA	p.E478K	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	478	Extracellular (Potential).|Calx-beta 4.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGATCTTCCAGAAGAGGCAGA	0.453													37	37					0	0	0.004289	0	0
ANKRD32	84250	broad.mit.edu	37	5	94030836	94030836	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:94030836C>A	uc003kkr.3	+	21	3076	c.2996C>A	c.(2995-2997)ACC>AAC	p.T999N	ANKRD32_uc003kks.2_Missense_Mutation_p.T363N	NM_032290	NP_115666	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32	999										ovary(2)	2		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)		CATAAAGAAACCACCAGTGTT	0.348													7	42					9.70103e-10	1.57946e-09	0.008291	1	0
LIX1	167410	broad.mit.edu	37	5	96460206	96460206	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:96460206C>T	uc003kmy.3	-	2	450	c.210G>A	c.(208-210)GTG>GTA	p.V70V		NM_153234	NP_694966	Q8N485	LIX1_HUMAN	limb expression 1	70										ovary(1)	1		all_cancers(142;4.28e-07)|all_epithelial(76;1.06e-09)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0318)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.0733)		CTGGGAGGGTCACGTAACTCA	0.473													37	47					0	0	0.004878	0	0
LOC100133050	100133050	broad.mit.edu	37	5	99715528	99715528	+	RNA	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:99715528C>T	uc011cuw.1	-	4		c.382G>A				NR_027503				Homo sapiens glucuronidase, beta pseudogene (LOC100133050), non-coding RNA.												0						AGCGGACAGTCGAAGCCCTTC	0.607													4	8					0	0	0.000248	0	0
FTMT	94033	broad.mit.edu	37	5	121187736	121187736	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:121187736C>T	uc003kss.2	+	1	87	c.78C>T	c.(76-78)TTC>TTT	p.F26F		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial precursor	26					cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		GCTGCTGCTTCGCGCTCCCGC	0.741													10	14					0	0	0.006214	0	0
SNCAIP	9627	broad.mit.edu	37	5	121761165	121761165	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:121761165G>A	uc003ksw.1	+	5	1327	c.1121G>A	c.(1120-1122)GGA>GAA	p.G374E	SNCAIP_uc011cwl.1_Intron|SNCAIP_uc010jct.2_Missense_Mutation_p.G374E|SNCAIP_uc003ksx.1_Missense_Mutation_p.G421E|SNCAIP_uc003ksy.1_Intron|SNCAIP_uc003ksz.1_Intron|SNCAIP_uc010jcu.2_Intron|SNCAIP_uc011cwm.1_Intron|SNCAIP_uc003kta.1_Intron|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Missense_Mutation_p.G68E|SNCAIP_uc010jcx.1_Intron	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	374	ANK 1.				cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		TCTTTGATGGGAGAAGACTGC	0.493													32	51					0	0	0.003755	0	0
PCDHA11	56138	broad.mit.edu	37	5	140248752	140248752	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:140248752G>A	uc003lia.2	+	1	922	c.64G>A	c.(64-66)GAA>AAA	p.E22K	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.E22K	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	22					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTCCTCCTCGAATTCTGGGA	0.577													60	56					0	0	0.003610	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140346810	140346810	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:140346810C>T	uc003lii.2	+	1	699	c.459C>T	c.(457-459)TAC>TAT	p.Y153Y	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Silent_p.Y153Y	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	153	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCCCAACTACCAGCTTCAGG	0.612													17	30					0	0	0.007413	0	0
PCDHB4	56131	broad.mit.edu	37	5	140503929	140503929	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:140503929G>A	uc003lip.1	+	1	2349	c.2349G>A	c.(2347-2349)AAG>AAA	p.K783K		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	783	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGAAGTTAAGGAAAACCCCA	0.448													22	45					0	0	0.003954	0	0
PCDHB5	26167	broad.mit.edu	37	5	140515407	140515407	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:140515407C>T	uc003liq.2	+	1	608	c.391C>T	c.(391-393)CCA>TCA	p.P131S		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	131	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGACCATGCCCCAGAGTTCCC	0.453													23	47					0	0	0.002780	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142526862	142526862	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:142526862T>C	uc011dbj.1	+	20	1939	c.1904T>C	c.(1903-1905)CTT>CCT	p.L635P	ARHGAP26_uc003lmt.2_Missense_Mutation_p.L635P|ARHGAP26_uc003lmw.2_Missense_Mutation_p.L635P	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal	635	Ser-rich.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AACAGCATCCTTAATTCCAGC	0.483													21	38					0	0	0.008871	0	0
C5orf46	389336	broad.mit.edu	37	5	147286010	147286010	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:147286010G>A	uc010jgp.2	-	1	92	c.55C>T	c.(55-57)CTG>TTG	p.L19L	C5orf46_uc003lou.2_Silent_p.L19L|C5orf46_uc003lov.3_Silent_p.L19L	NM_206966	NP_996849	Q6UWT4	CE046_HUMAN	hypothetical protein LOC389336 precursor	19						extracellular region					0						TAGCAGGTCAGGAATAAGACA	0.453													10	17					0	0	0.001368	0	0
ZNF300	91975	broad.mit.edu	37	5	150275613	150275613	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:150275613C>T	uc003lsy.1	-	6	1455	c.1188G>A	c.(1186-1188)CTG>CTA	p.L396L	IRGM_uc011dcl.1_Intron	NM_052860	NP_443092	Q96RE9	ZN300_HUMAN	zinc finger protein 300	396	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGTGTATAATCAGCTGTGACT	0.443													27	30					0	0	0.006320	0	0
SLC36A2	153201	broad.mit.edu	37	5	150714951	150714951	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:150714951G>A	uc003lty.2	-	6	813	c.683C>T	c.(682-684)TCC>TTC	p.S228F	GM2A_uc011dcs.1_Intron|SLC36A2_uc003ltz.2_RNA|SLC36A2_uc003lua.2_Missense_Mutation_p.S30F|SLC36A2_uc010jhv.2_Missense_Mutation_p.S228F	NM_181776	NP_861441	Q495M3	S36A2_HUMAN	solute carrier family 36, member 2	228	Helical; (Potential).				cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGCCAGCATGGAGAAGATGGT	0.567													22	36					0	0	0.001523	0	0
GLRA1	2741	broad.mit.edu	37	5	151239414	151239414	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:151239414G>A	uc003lut.2	-	4	695	c.408C>T	c.(406-408)TTC>TTT	p.F136F	GLRA1_uc003lur.2_Silent_p.F136F|GLRA1_uc003lus.2_Silent_p.F53F	NM_001146040	NP_001139512	P23415	GLRA1_HUMAN	glycine receptor, alpha 1 isoform 1 precursor	136	Extracellular (Probable).				muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			ovary(1)|central_nervous_system(1)	2		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TGATCTCATGGAAGTGGGCCC	0.522													48	38					0	0	0.003610	0	0
GABRB2	2561	broad.mit.edu	37	5	160721238	160721238	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:160721238C>T	uc003lys.1	-	11	1607	c.1389G>A	c.(1387-1389)AAG>AAA	p.K463K	GABRB2_uc011deh.1_Silent_p.K264K|GABRB2_uc003lyr.1_Silent_p.K425K|GABRB2_uc003lyt.1_Silent_p.K425K|GABRB2_uc010jiu.1_Silent_p.K362K	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	463	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GGCGACTTTTCTTTTGCGCCA	0.522													10	30					0	0	0.006214	0	0
TRIM7	81786	broad.mit.edu	37	5	180625208	180625208	+	Silent	SNP	C	G	G			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:180625208C>G	uc003mmz.1	-	6	1066	c.999G>C	c.(997-999)CGG>CGC	p.R333R	TRIM7_uc003mmv.1_Silent_p.R151R|TRIM7_uc003mmw.1_Silent_p.R125R|TRIM7_uc003mmx.1_Silent_p.R125R|TRIM7_uc003mmy.1_Silent_p.R125R	NM_203293	NP_976038	Q9C029	TRIM7_HUMAN	tripartite motif-containing 7 isoform 1	333	B30.2/SPRY.					cytoplasm|nucleus	zinc ion binding			ovary(2)|skin(1)	3	all_cancers(89;6.03e-06)|all_epithelial(37;7.1e-07)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000172)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;2e-06)|Epithelial(171;1.35e-05)|OV - Ovarian serous cystadenocarcinoma(192;0.000128)|Kidney(146;0.0674)|GBM - Glioblastoma multiforme(465;0.0802)		CCAGCTCTCCCCGAAGGTCCT	0.527													3	38					0	0	0.000248	0	0
TRIM7	81786	broad.mit.edu	37	5	180625727	180625727	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr5:180625727C>T	uc003mmz.1	-	5	1018	c.951G>A	c.(949-951)AAG>AAA	p.K317K	TRIM7_uc003mmv.1_Silent_p.K135K|TRIM7_uc003mmw.1_Silent_p.K109K|TRIM7_uc003mmx.1_Silent_p.K109K|TRIM7_uc003mmy.1_Silent_p.K109K	NM_203293	NP_976038	Q9C029	TRIM7_HUMAN	tripartite motif-containing 7 isoform 1	317						cytoplasm|nucleus	zinc ion binding			ovary(2)|skin(1)	3	all_cancers(89;6.03e-06)|all_epithelial(37;7.1e-07)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000172)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;2e-06)|Epithelial(171;1.35e-05)|OV - Ovarian serous cystadenocarcinoma(192;0.000128)|Kidney(146;0.0674)|GBM - Glioblastoma multiforme(465;0.0802)		AGACAAAGGTCTTGAGAGAAA	0.527													11	27					0	0	0.000978	0	0
DDR1	780	broad.mit.edu	37	6	30864588	30864589	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr6:30864588_30864589CC>TT	uc003nrr.2	+	14	2074_2075	c.1815_1816CC>TT	c.(1813-1818)TTCCCT>TTTTCT	p.P606S	DDR1_uc010jse.2_Missense_Mutation_p.P569S|DDR1_uc003nrq.2_Missense_Mutation_p.P569S|DDR1_uc003nrs.2_Missense_Mutation_p.P606S|DDR1_uc003nrt.2_Missense_Mutation_p.P569S|DDR1_uc011dms.1_Missense_Mutation_p.P587S|DDR1_uc003nru.2_Missense_Mutation_p.P569S|DDR1_uc003nrv.2_Missense_Mutation_p.P606S|DDR1_uc003nrw.1_Missense_Mutation_p.P341S|DDR1_uc003nry.1_Intron|DDR1_uc003nrx.1_Intron|DDR1_uc003nrz.1_5'Flank	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	606	Cytoplasmic (Potential).				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	GAGTGGATTTCCCTCGATCTCG	0.619													32	38					0	0	0.004672	0	0
CYP21A2	1589	broad.mit.edu	37	6	32008470	32008470	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr6:32008470G>A	uc003nze.1	+	9	1262	c.1144G>A	c.(1144-1146)GGC>AGC	p.G382S	CYP21A2_uc003nzf.1_Missense_Mutation_p.G352S	NM_000500	NP_000491	P08686	CP21A_HUMAN	cytochrome P450, family 21, subfamily A,	381					glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding				0						CATCCCTGAGGGCACAGTCAT	0.642													7	69					0	0	0.005443	0	0
GPSM3	63940	broad.mit.edu	37	6	32159178	32159178	+	Nonsense_Mutation	SNP	C	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr6:32159178C>A	uc003oay.3	-	4	841	c.448G>T	c.(448-450)GAG>TAG	p.E150*	PBX2_uc003oav.1_5'Flank|PBX2_uc003oaw.2_5'Flank|GPSM3_uc003oax.3_Nonsense_Mutation_p.E127*|GPSM3_uc003oaz.2_Nonsense_Mutation_p.E150*	NM_022107	NP_071390	Q9Y4H4	GPSM3_HUMAN	G-protein signaling modulator 3 (AGS3-like, C.	150	GoLoco 3.				signal transduction	cytoplasm	GTPase activator activity|protein binding				0						GACCTTTGCTCCTCCATTCGA	0.647													111	126					9.67539e-52	1.61174e-51	0.003610	1	0
DNAH8	1769	broad.mit.edu	37	6	38738263	38738263	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr6:38738263G>A	uc003ooe.1	+	10	1641	c.1041G>A	c.(1039-1041)GGG>GGA	p.G347G		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AATCCTCAGGGGAAAAATCTT	0.343													20	10					0	0	0.007413	0	0
IL17A	3605	broad.mit.edu	37	6	52052559	52052559	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr6:52052559G>A	uc003pak.1	+	2	231	c.186G>A	c.(184-186)AGG>AGA	p.R62R		NM_002190	NP_002181	Q16552	IL17_HUMAN	interleukin 17A precursor	62					apoptosis|cell-cell signaling|fibroblast activation|immune response|inflammatory response|positive regulation of interleukin-23 production|positive regulation of osteoclast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein glycosylation	extracellular space	cytokine activity				0	Lung NSC(77;0.116)					ATCCCAAAAGGTCCTCAGATT	0.443													22	75					0	0	0.002299	0	0
LGSN	51557	broad.mit.edu	37	6	63990205	63990205	+	Nonsense_Mutation	SNP	G	C	C			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr6:63990205G>C	uc003peh.2	-	4	1285	c.1251C>G	c.(1249-1251)TAC>TAG	p.Y417*	LGSN_uc003pei.2_3'UTR	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	417					glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	CCAGCACCAAGTAAGGGTTTG	0.458													17	51					0	0	0.004990	0	0
COL12A1	1303	broad.mit.edu	37	6	75887636	75887636	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr6:75887636C>T	uc003phs.2	-	12	2346	c.2180G>A	c.(2179-2181)CGA>CAA	p.R727Q	COL12A1_uc003pht.2_Intron|COL12A1_uc003phu.1_Missense_Mutation_p.R385Q	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	727	Fibronectin type-III 4.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						CTTTAGGTTTCGAGGTGCTCC	0.294													38	32					0	0	0.006999	0	0
ELOVL4	6785	broad.mit.edu	37	6	80635910	80635910	+	Splice_Site	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr6:80635910C>T	uc003pja.3	-	2	607	c.288_splice	c.e2+1	p.E96_splice	ELOVL4_uc011dyt.1_Intron	NM_022726	NP_073563	Q9GZR5	ELOV4_HUMAN	elongation of very long chain fatty acids-like						fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	G-protein coupled photoreceptor activity|protein binding|transferase activity, transferring acyl groups other than amino-acyl groups			ovary(1)|skin(1)	2		all_cancers(76;1.83e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.011)		BRCA - Breast invasive adenocarcinoma(397;0.0168)	Alpha-Linolenic Acid(DB00132)	TAAAAACATACCTCTCTGAAG	0.318													6	12					0	0	0.001168	0	0
SNAP91	9892	broad.mit.edu	37	6	84291985	84291985	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr6:84291985C>T	uc011dze.1	-	22	2422	c.2105G>A	c.(2104-2106)GGG>GAG	p.G702E	SNAP91_uc011dzd.1_Missense_Mutation_p.G205E|SNAP91_uc003pkb.2_Missense_Mutation_p.G611E|SNAP91_uc003pkc.2_Missense_Mutation_p.G672E|SNAP91_uc003pkd.2_Missense_Mutation_p.G395E|SNAP91_uc003pka.2_Missense_Mutation_p.G700E	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog	702					clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		AGGCGTTGTCCCAAAAGCTGC	0.453													28	27					0	0	0.007291	0	0
HACE1	57531	broad.mit.edu	37	6	105233061	105233061	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr6:105233061G>A	uc003pqu.1	-	12	1485	c.1208C>T	c.(1207-1209)GCT>GTT	p.A403V	HACE1_uc010kcy.1_5'UTR|HACE1_uc010kcz.1_Missense_Mutation_p.A403V|HACE1_uc010kcx.1_5'UTR|HACE1_uc003pqt.1_Missense_Mutation_p.A56V	NM_020771	NP_065822	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing, E3	403					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			ovary(5)|lung(2)	7		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		AGGAATGGAAGCAGCATCTTG	0.423													32	27					0	0	0.002445	0	0
NR2E1	7101	broad.mit.edu	37	6	108502054	108502054	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr6:108502054C>T	uc003psg.2	+	7	1538	c.783C>T	c.(781-783)ATC>ATT	p.I261I		NM_003269	NP_003260	Q9Y466	NR2E1_HUMAN	nuclear receptor subfamily 2, group E, member 1	261	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(87;8.13e-05)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00866)|Colorectal(196;0.0637)		BRCA - Breast invasive adenocarcinoma(108;0.013)|Epithelial(106;0.0521)|all cancers(137;0.068)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)		TGAACAAGATCATATCTGAAA	0.373													43	24					0	0	0.002222	0	0
DDO	8528	broad.mit.edu	37	6	110714493	110714493	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr6:110714493C>T	uc003puc.2	-	5	599	c.595G>A	c.(595-597)GAA>AAA	p.E199K	C6orf186_uc003pub.2_Intron|DDO_uc003pud.2_Missense_Mutation_p.E140K	NM_003649	NP_003640	Q99489	OXDD_HUMAN	D-aspartate oxidase isoform a	171					aspartate catabolic process	peroxisome	binding|D-amino-acid oxidase activity|D-aspartate oxidase activity			ovary(2)|breast(1)	3		all_cancers(87;3.47e-21)|all_epithelial(87;9.03e-20)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_lung(197;2.98e-05)|Lung NSC(302;3.25e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.00327)		all cancers(137;2.54e-48)|Epithelial(106;3.11e-44)|OV - Ovarian serous cystadenocarcinoma(136;2.08e-24)|BRCA - Breast invasive adenocarcinoma(108;0.000141)|GBM - Glioblastoma multiforme(226;0.00046)		GGATGAAGTTCCCACAGGTCT	0.498													48	47					0	0	0.003610	0	0
RFX6	222546	broad.mit.edu	37	6	117237424	117237424	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr6:117237424G>A	uc003pxm.2	+	9	982	c.919G>A	c.(919-921)GAA>AAA	p.E307K		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	307					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						TCCCCTGCTCGAAAATCCTGT	0.343													49	36					0	0	0.003610	0	0
THEMIS	387357	broad.mit.edu	37	6	128176299	128176299	+	Silent	SNP	A	G	G			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr6:128176299A>G	uc003qbi.2	-	3	445	c.126T>C	c.(124-126)TGT>TGC	p.C42C	THEMIS_uc010kfa.2_5'UTR|THEMIS_uc011ebt.1_Silent_p.C42C|THEMIS_uc010kfb.2_Silent_p.C7C	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	42	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						CTGTTGAAAAACAGCATTCAT	0.318													14	5					0	0	0.002450	0	0
UTRN	7402	broad.mit.edu	37	6	144780342	144780342	+	Silent	SNP	C	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr6:144780342C>A	uc003qkt.2	+	20	2651	c.2559C>A	c.(2557-2559)CCC>CCA	p.P853P	UTRN_uc010khq.1_Silent_p.P853P	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	853	Interaction with SYNM.|Spectrin 6.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GCCTTCACCCCAAAATTGAAA	0.507													24	18					9.57634e-11	1.56309e-10	0.003330	1	0
GPER	2852	broad.mit.edu	37	7	1131809	1131810	+	Missense_Mutation	DNP	AC	TA	TA			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:1131809_1131810AC>TA	uc010ksd.1	+	2	834_835	c.445_446AC>TA	c.(445-447)ACC>TAC	p.T149Y	C7orf50_uc003sju.2_Intron|C7orf50_uc011jvt.1_Intron|C7orf50_uc011jvu.1_Intron|GPER_uc003sjz.1_Missense_Mutation_p.T149Y|GPER_uc003ska.1_Missense_Mutation_p.T149Y|GPER_uc003skb.2_Missense_Mutation_p.T149Y	NM_001098201	NP_001091671	Q99527	GPER_HUMAN	G protein-coupled receptor 30	149	Helical; Name=3; (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;2.32e-16)		CTTCTTCCTCACCTGGATGAGC	0.614													16	50					0	0	0.004672	0	0
INTS1	26173	broad.mit.edu	37	7	1518129	1518129	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:1518129G>A	uc003skn.2	-	33	4604	c.4503C>T	c.(4501-4503)CTC>CTT	p.L1501L	INTS1_uc003skm.1_5'Flank	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1501					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CCAGGCGCAGGAGCCCCCCTC	0.687													7	18					0	0	0.006214	0	0
SDK1	221935	broad.mit.edu	37	7	4152989	4152989	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:4152989C>T	uc003smx.2	+	24	3642	c.3503C>T	c.(3502-3504)ACC>ATC	p.T1168I	SDK1_uc010kso.2_Missense_Mutation_p.T444I	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1168	Fibronectin type-III 5.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GTCATCCAGACCCTGCAGGCC	0.597													75	73					0	0	0.003610	0	0
RBAK	57786	broad.mit.edu	37	7	5104616	5104617	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:5104616_5104617CC>TT	uc010kss.1	+	6	1853_1854	c.1529_1530CC>TT	c.(1528-1530)CCC>CTT	p.P510L	LOC389458_uc003snr.2_Intron|RBAK_uc003sns.1_Missense_Mutation_p.P510L	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	510	Interaction with AR.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		GAAGAGAAACCCTATGAATGTA	0.401													10	32					0	0	0.004672	0	0
BBS9	27241	broad.mit.edu	37	7	33392474	33392474	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:33392474G>A	uc003tdn.1	+	15	2054	c.1541G>A	c.(1540-1542)CGA>CAA	p.R514Q	BBS9_uc003tdo.1_Missense_Mutation_p.R479Q|BBS9_uc003tdp.1_Intron|BBS9_uc003tdq.1_Intron|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_Missense_Mutation_p.R38Q|BBS9_uc003tds.1_5'UTR|BBS9_uc011kao.1_Missense_Mutation_p.R392Q	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	514					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			TGGACAGATCGAAATCCTGAT	0.323									Bardet-Biedl_syndrome				12	27					0	0	0.002450	0	0
ANLN	54443	broad.mit.edu	37	7	36450695	36450695	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:36450695C>T	uc003tff.2	+	7	1519	c.1315C>T	c.(1315-1317)CGT>TGT	p.R439C	ANLN_uc011kaz.1_Missense_Mutation_p.R351C|ANLN_uc003tfg.2_Missense_Mutation_p.R439C|ANLN_uc010kxe.2_Missense_Mutation_p.R439C	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	439	Interaction with F-actin.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3						AGCATGTCTTCGTGGCCGATT	0.368													7	37					0	0	0.006214	0	0
IKZF1	10320	broad.mit.edu	37	7	50467675	50467675	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:50467675G>A	uc003tow.3	+	9	1078	c.910G>A	c.(910-912)GAA>AAA	p.E304K	IKZF1_uc003tox.3_Missense_Mutation_p.E262K|IKZF1_uc003toy.3_Missense_Mutation_p.E262K|IKZF1_uc011kck.1_Missense_Mutation_p.E217K|IKZF1_uc003toz.3_Missense_Mutation_p.E274K|IKZF1_uc010kyx.2_Missense_Mutation_p.E44K|IKZF1_uc003tpa.3_Missense_Mutation_p.E46K	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	304					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding			haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				GAAGGAGAACGAAATGATGAA	0.652			D		ALL								10	5					0	0	0.000978	0	0
ZNF713	349075	broad.mit.edu	37	7	56006850	56006850	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:56006850G>A	uc003trc.1	+	4	482	c.444G>A	c.(442-444)AAG>AAA	p.K148K	ZNF713_uc003tra.1_Silent_p.K161K|MRPS17_uc003trb.2_Intron	NM_182633	NP_872439	Q8N859	ZN713_HUMAN	zinc finger protein 713	148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			AAAACCACAAGAGATATTTAG	0.408													6	28					0	0	0.001168	0	0
GRM3	2913	broad.mit.edu	37	7	86469140	86469140	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:86469140C>T	uc003uid.2	+	4	3409	c.2310C>T	c.(2308-2310)TTC>TTT	p.F770F	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Silent_p.F642F|GRM3_uc010leh.2_Silent_p.F362F	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	770	Helical; Name=6; (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	AAGCTAAGTTCATAGGTTTTA	0.423													50	30					0	0	0.003610	0	0
DBF4	10926	broad.mit.edu	37	7	87516704	87516704	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:87516704C>T	uc003ujf.1	+	5	1015	c.511C>T	c.(511-513)CAT>TAT	p.H171Y	DBF4_uc003ujh.1_5'UTR|DBF4_uc003ujg.1_5'UTR|DBF4_uc011khf.1_5'UTR	NM_006716	NP_006707	Q9UBU7	DBF4A_HUMAN	activator of S phase kinase	171	BRCT 2.				cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			lung(2)	2	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				AAAAATTCTTCATATTGATGG	0.279													18	8					0	0	0.002299	0	0
ZNF804B	219578	broad.mit.edu	37	7	88964313	88964313	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:88964313T>G	uc011khi.1	+	4	2555	c.2017T>G	c.(2017-2019)TTC>GTC	p.F673V		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	673						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TGGGAAAGACTTCAGTGTAAT	0.438										HNSCC(36;0.09)			3	48					0	0	0.004672	0	0
C7orf64	84060	broad.mit.edu	37	7	92161833	92161833	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:92161833G>A	uc003ulz.2	+	3	459	c.418G>A	c.(418-420)GCA>ACA	p.A140T	C7orf64_uc011khu.1_Missense_Mutation_p.A140T|C7orf64_uc003uma.2_Missense_Mutation_p.A140T	NM_032120	NP_115496	Q5RL73	CG064_HUMAN	hypothetical protein LOC84060	140							nucleotide binding			ovary(2)	2						AATGCGGAAGGCATATGTAGT	0.254													8	45					0	0	0.003080	0	0
MUC17	140453	broad.mit.edu	37	7	100686664	100686664	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:100686664G>A	uc003uxp.1	+	3	12020	c.11967G>A	c.(11965-11967)AAG>AAA	p.K3989K	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3989	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CAACTACTAAGGAATTTACAA	0.478													27	110					0	0	0.002445	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518267	113518267	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:113518267G>A	uc010ljy.1	-	4	2911	c.2880C>T	c.(2878-2880)ATC>ATT	p.I960I		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	960					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						CAATACCCTGGATTTCTCTTG	0.388													64	29					0	0	0.003610	0	0
ARF5	381	broad.mit.edu	37	7	127229612	127229613	+	Missense_Mutation	DNP	TC	AT	AT			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:127229612_127229613TC>AT	uc003vmb.1	+	3	258_259	c.222_223TC>AT	c.(220-225)ATTCGG>ATATGG	p.R75W	ARF5_uc010llb.1_Missense_Mutation_p.R75W|FSCN3_uc003vmc.1_5'Flank	NM_001662	NP_001653	P84085	ARF5_HUMAN	ADP-ribosylation factor 5	75					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	Golgi apparatus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1						AGGACAAGATTCGGCCTCTGTG	0.485													15	72					0	0	0.004672	0	0
FLNC	2318	broad.mit.edu	37	7	128490461	128490461	+	Silent	SNP	T	C	C			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:128490461T>C	uc003vnz.3	+	32	5531	c.5322T>C	c.(5320-5322)CCT>CCC	p.P1774P	FLNC_uc003voa.3_Silent_p.P1741P	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1774	Filamin 16.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CAGTGGTGCCTGTGGAGCCAA	0.607													4	178					0	0	0.000248	0	0
FAM40B	57464	broad.mit.edu	37	7	129098202	129098202	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:129098202C>T	uc011koy.1	+	10	1225	c.1185C>T	c.(1183-1185)GAC>GAT	p.D395D	FAM40B_uc003vow.2_Silent_p.D395D|FAM40B_uc011koz.1_5'UTR	NM_020704	NP_065755	Q9ULQ0	FA40B_HUMAN	hypothetical protein LOC57464 isoform a	395											0						TAGAGCAGGACCCTCTGGTGC	0.597													16	13					0	0	0.004007	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				68	26					0	0	0.003610	0	0
TAS2R38	5726	broad.mit.edu	37	7	141672908	141672908	+	Silent	SNP	G	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:141672908G>T	uc003vwx.1	-	1	666	c.582C>A	c.(580-582)TCC>TCA	p.S194S		NM_176817	NP_789787	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	194	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|skin(1)	2	Melanoma(164;0.0171)					AGAAGAGAAAGGAATAAAATA	0.418													12	51					5.50884e-06	8.92432e-06	0.001368	1	0
MGAM	8972	broad.mit.edu	37	7	141754553	141754553	+	Splice_Site	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:141754553G>A	uc003vwy.2	+	27	3214	c.3160_splice	c.e27-1	p.I1054_splice		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase						polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CTCTGGCCTAGATTTATGATC	0.428													118	59					0	0	0.003610	0	0
TAS2R60	338398	broad.mit.edu	37	7	143140983	143140983	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:143140983C>T	uc011ktg.1	+	1	438	c.438C>T	c.(436-438)TTC>TTT	p.F146F	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	146	Helical; Name=4; (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)					GGATGCTCTTCAGCTCTGTAG	0.453													33	148					0	0	0.002096	0	0
TAS2R60	338398	broad.mit.edu	37	7	143141493	143141493	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:143141493G>A	uc011ktg.1	+	1	948	c.948G>A	c.(946-948)GGG>GGA	p.G316G	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	316	Cytoplasmic (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)					CAAGGTGTGGGACACCTTGAG	0.483													16	112					0	0	0.006122	0	0
EZH2	2146	broad.mit.edu	37	7	148514973	148514973	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr7:148514973G>A	uc003wfd.1	-	10	1387	c.1221C>T	c.(1219-1221)TCC>TCT	p.S407S	EZH2_uc011kug.1_Silent_p.S398S|EZH2_uc003wfb.1_Silent_p.S412S|EZH2_uc003wfc.1_Silent_p.S368S|EZH2_uc011kuh.1_Silent_p.S398S|EZH2_uc011kui.1_Silent_p.S407S|EZH2_uc011kuj.1_RNA	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a	407					negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			TCTTACCAGAGGAGCTCGAAG	0.393			Mis		DLBCL								14	70					0	0	0.007413	0	0
CSMD1	64478	broad.mit.edu	37	8	2813184	2813184	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr8:2813184G>A	uc011kwk.1	-	64	10314	c.9924C>T	c.(9922-9924)TTC>TTT	p.F3308F	CSMD1_uc011kwj.1_Silent_p.F2637F|CSMD1_uc010lrg.2_Silent_p.F1199F	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3308	Sushi 28.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCCCTGCGAGGAAAAAGCCTG	0.507													37	42					0	0	0.004289	0	0
MCPH1	79648	broad.mit.edu	37	8	6302683	6302683	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr8:6302683C>T	uc003wqi.2	+	8	1508	c.1440C>T	c.(1438-1440)ACC>ACT	p.T480T	MCPH1_uc003wqh.2_Silent_p.T480T|MCPH1_uc011kwl.1_Silent_p.T432T	NM_024596	NP_078872	Q8NEM0	MCPH1_HUMAN	microcephalin	480						microtubule organizing center				central_nervous_system(1)|skin(1)	2		Hepatocellular(245;0.0663)		Colorectal(4;0.0505)		CAGCAAAAACCATCTCCAGTC	0.443													37	38					0	0	0.004878	0	0
SLC7A2	6542	broad.mit.edu	37	8	17401060	17401060	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr8:17401060C>T	uc011kyc.1	+	2	381	c.212C>T	c.(211-213)TCC>TTC	p.S71F	SLC7A2_uc011kyd.1_Missense_Mutation_p.S111F|SLC7A2_uc011kye.1_Missense_Mutation_p.S111F|SLC7A2_uc011kyf.1_Missense_Mutation_p.S71F	NM_001008539	NP_001008539	P52569	CTR2_HUMAN	solute carrier family 7, member 2 isoform 2	71	Helical; (Potential).				cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			ovary(2)|skin(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	ATCGTGGTGTCCTTCCTCATT	0.612													20	27					0	0	0.008871	0	0
ADAM7	8756	broad.mit.edu	37	8	24300064	24300064	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr8:24300064G>A	uc003xeb.2	+	2	244	c.131G>A	c.(130-132)GGA>GAA	p.G44E	ADAM7_uc003xea.1_Missense_Mutation_p.G44E	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	44	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		CGAGATACTGGACACACCCAT	0.413													31	122					0	0	0.001786	0	0
SCARA5	286133	broad.mit.edu	37	8	27729502	27729502	+	Silent	SNP	C	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr8:27729502C>A	uc003xgj.2	-	9	1877	c.1437G>T	c.(1435-1437)GTG>GTT	p.V479V	SCARA5_uc010luz.2_Silent_p.V254V	NM_173833	NP_776194	Q6ZMJ2	SCAR5_HUMAN	scavenger receptor class A, member 5	479	SRCR.|Extracellular (Potential).				cellular iron ion homeostasis|endocytosis|iron ion transmembrane transport|protein homotrimerization	integral to plasma membrane	ferritin receptor activity|scavenger receptor activity			central_nervous_system(1)|skin(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)|Colorectal(74;0.228)		CACAGTTTGTCACCCCCCATT	0.577													27	39					2.12542e-12	3.51344e-12	0.006320	1	0
RP1	6101	broad.mit.edu	37	8	55538614	55538614	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr8:55538614G>A	uc003xsd.1	+	4	2320	c.2172G>A	c.(2170-2172)GGG>GGA	p.G724G	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	724					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTAAAGGAGGGATACTTTGTG	0.338													17	27					0	0	0.004007	0	0
RP1	6101	broad.mit.edu	37	8	55539794	55539794	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr8:55539794C>T	uc003xsd.1	+	4	3500	c.3352C>T	c.(3352-3354)CAT>TAT	p.H1118Y	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1118					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGTTCCCTTTCATTCTGCAAT	0.423													16	28					0	0	0.003163	0	0
EYA1	2138	broad.mit.edu	37	8	72229851	72229851	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr8:72229851G>A	uc003xys.3	-	6	779	c.492C>T	c.(490-492)CTC>CTT	p.L164L	EYA1_uc003xyr.3_Silent_p.L159L|EYA1_uc003xyt.3_Silent_p.L131L|EYA1_uc010lzf.2_Silent_p.L91L|EYA1_uc003xyu.2_Silent_p.L164L|EYA1_uc011lfe.1_Silent_p.L158L|EYA1_uc003xyv.2_Silent_p.L42L	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	164					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			TGCCATAGCTGAGAAATCCTG	0.463													62	112					0	0	0.003610	0	0
VPS13B	157680	broad.mit.edu	37	8	100479687	100479687	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr8:100479687A>G	uc003yiv.2	+	24	3602	c.3491A>G	c.(3490-3492)TAT>TGT	p.Y1164C	VPS13B_uc003yiw.2_Missense_Mutation_p.Y1164C|VPS13B_uc003yiu.1_Missense_Mutation_p.Y1164C|VPS13B_uc003yix.1_Missense_Mutation_p.Y634C	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1164					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TTCAGCATATATACCCTTCTT	0.428													58	152					0	0	0.003610	0	0
ATAD2	29028	broad.mit.edu	37	8	124359340	124359340	+	Nonsense_Mutation	SNP	A	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr8:124359340A>T	uc003yqh.3	-	16	2312	c.2204T>A	c.(2203-2205)TTA>TAA	p.L735*	ATAD2_uc011lii.1_Nonsense_Mutation_p.L526*|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Nonsense_Mutation_p.L735*	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	735					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			ACCTGAGTCTAATGTTTTATT	0.318													17	50					0	0	0.004990	0	0
OC90	729330	broad.mit.edu	37	8	133045342	133045342	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr8:133045342G>A	uc003ytg.2	-	10	803	c.803C>T	c.(802-804)TCT>TTT	p.S268F	OC90_uc011lix.1_Missense_Mutation_p.S268F	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	284					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			CAGCCCCAGAGATTTAATGCC	0.453													5	11					0	0	0.000602	0	0
GPR20	2843	broad.mit.edu	37	8	142367699	142367699	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr8:142367699G>A	uc003ywf.2	-	2	414	c.325C>T	c.(325-327)CGC>TGC	p.R109C		NM_005293	NP_005284	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	109	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity	p.R109H(1)		upper_aerodigestive_tract(1)	1	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			ACAGCGAAGCGCGTGGGCAGG	0.617													25	41					0	0	0.002780	0	0
RUSC2	9853	broad.mit.edu	37	9	35548090	35548090	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr9:35548090G>A	uc003zww.2	+	2	1827	c.1572G>A	c.(1570-1572)TTG>TTA	p.L524L	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Silent_p.L524L	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	524						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			CAGTGCGCTTGAGTGAGGGCC	0.667													4	39					0	0	0.000602	0	0
TMC1	117531	broad.mit.edu	37	9	75435973	75435973	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr9:75435973C>T	uc004aiz.1	+	20	2519	c.1979C>T	c.(1978-1980)CCA>CTA	p.P660L	TMC1_uc010moz.1_Missense_Mutation_p.P618L|TMC1_uc004aja.1_RNA|TMC1_uc004ajb.1_RNA|TMC1_uc004ajc.1_Missense_Mutation_p.P514L|TMC1_uc010mpa.1_Missense_Mutation_p.P514L	NM_138691	NP_619636	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	660	Extracellular (Potential).				sensory perception of sound	integral to membrane				ovary(1)	1						TCCCTCCCACCATCTTTTGAT	0.458													128	31					0	0	0.003610	0	0
SVEP1	79987	broad.mit.edu	37	9	113192706	113192706	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr9:113192706C>T	uc010mtz.2	-	33	5715	c.5378G>A	c.(5377-5379)GGA>GAA	p.G1793E	SVEP1_uc010mty.2_5'Flank	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1793	Sushi 7.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						TTCCGGATTTCCTGGAGCCTT	0.423													20	2					0	0	0.001882	0	0
SVEP1	79987	broad.mit.edu	37	9	113238568	113238568	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr9:113238568C>T	uc010mtz.2	-	14	2852	c.2515G>A	c.(2515-2517)GAC>AAC	p.D839N	SVEP1_uc010mua.1_Missense_Mutation_p.D839N|SVEP1_uc004beu.2_Missense_Mutation_p.D839N	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	839					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						CAGTCAATGTCCTCTGCATCA	0.303													73	11					0	0	0.003610	0	0
PDCL	5082	broad.mit.edu	37	9	125582800	125582801	+	Missense_Mutation	DNP	TG	AT	AT			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr9:125582800_125582801TG>AT	uc004bmz.1	-	4	565_566	c.469_470CA>AT	c.(469-471)CAA>ATA	p.Q157I	PDCL_uc004bna.2_3'UTR	NM_005388	NP_005379	Q13371	PHLP_HUMAN	phosducin-like	157					signal transduction|visual perception						0						CTGCTTGAATTGGGGCCCCTTG	0.436													48	19					0	0	0.004672	0	0
DBH	1621	broad.mit.edu	37	9	136501646	136501646	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr9:136501646C>T	uc004cel.2	+	1	162	c.153C>T	c.(151-153)ATC>ATT	p.I51I		NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	51	Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	CCTATCACATCCCCCTGGACC	0.642													19	7					0	0	0.006122	0	0
CAMSAP1	157922	broad.mit.edu	37	9	138713473	138713473	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr9:138713473C>T	uc004cgr.3	-	11	3034	c.3034G>A	c.(3034-3036)GGG>AGG	p.G1012R	CAMSAP1_uc004cgq.3_Missense_Mutation_p.G902R|CAMSAP1_uc010nbg.2_Missense_Mutation_p.G734R	NM_015447	NP_056262	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein	1012						cytoplasm|microtubule				ovary(1)|central_nervous_system(1)|pancreas(1)	3				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		ACAACCTCCCCAACAGTGTCC	0.522													24	9					0	0	0.003954	0	0
CXorf22	170063	broad.mit.edu	37	X	35994002	35994002	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chrX:35994002G>A	uc004ddj.2	+	15	2744	c.2685G>A	c.(2683-2685)GGG>GGA	p.G895G	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	895										large_intestine(1)|lung(1)|ovary(1)	3						CAGGAAGAGGGATAGCATTTT	0.308													51	13					0	0	0.003610	0	0
FAM47C	442444	broad.mit.edu	37	X	37026916	37026916	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chrX:37026916C>T	uc004ddl.1	+	1	447	c.433C>T	c.(433-435)CTC>TTC	p.L145F		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	145										ovary(3)	3						GCCTCCAGATCTCCTACTACA	0.577													36	11					0	0	0.003755	0	0
SSX3	10214	broad.mit.edu	37	X	48214129	48214129	+	Missense_Mutation	SNP	T	C	C	rs113403735		TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chrX:48214129T>C	uc004djd.1	-	3	216	c.122A>G	c.(121-123)AAA>AGA	p.K41R	SSX3_uc004dje.2_Missense_Mutation_p.K41R|SSX3_uc010nic.2_Missense_Mutation_p.K41R	NM_021014	NP_066294	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3 isoform a	41	KRAB-related.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding				0						CTCCGAGACTTTCATCTTTTC	0.398													57	9					0	0	0.003610	0	0
FAAH2	158584	broad.mit.edu	37	X	57405106	57405106	+	Silent	SNP	G	A	A			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chrX:57405106G>A	uc004dvc.2	+	6	914	c.765G>A	c.(763-765)CAG>CAA	p.Q255Q		NM_174912	NP_777572	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	255						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			ovary(3)	3						ACAAAGGTCAGTTTCCCTTGG	0.493										HNSCC(52;0.14)			41	7					0	0	0.002522	0	0
TEX11	56159	broad.mit.edu	37	X	69843814	69843814	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chrX:69843814C>T	uc004dyl.2	-	21	1944	c.1782G>A	c.(1780-1782)CCG>CCA	p.P594P	TEX11_uc004dyk.2_Silent_p.P269P|TEX11_uc004dym.2_Silent_p.P579P	NM_001003811	NP_001003811	Q8IYF3	TEX11_HUMAN	testis expressed sequence 11 isoform 1	594							protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)					CTTCAGATTCCGGCATTTCAG	0.303													34	7					0	0	0.004289	0	0
MUM1L1	139221	broad.mit.edu	37	X	105450147	105450147	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chrX:105450147C>T	uc004emf.1	+	4	1371	c.722C>T	c.(721-723)TCA>TTA	p.S241L	MUM1L1_uc004emg.1_Missense_Mutation_p.S241L	NM_152423	NP_689636	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	241										ovary(2)|pancreas(1)|skin(1)	4						CCACCTTTGTCACCTTTGTCA	0.428													19	0					0	0	0.008871	0	0
MCF2	4168	broad.mit.edu	37	X	138708441	138708441	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chrX:138708441C>T	uc004fau.2	-	6	892	c.598G>A	c.(598-600)GAA>AAA	p.E200K	MCF2_uc004fav.2_Missense_Mutation_p.E200K|MCF2_uc011mwl.1_Missense_Mutation_p.E161K|MCF2_uc010nsh.1_Missense_Mutation_p.E200K|MCF2_uc011mwm.1_Missense_Mutation_p.E161K|MCF2_uc011mwn.1_Missense_Mutation_p.E345K|MCF2_uc004faw.2_Missense_Mutation_p.E260K|MCF2_uc011mwo.1_Missense_Mutation_p.E260K	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	200					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					AAAGCTGTTTCCATATCATGT	0.343													33	7					0	0	0.004289	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995273	140995273	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chrX:140995273C>T	uc004fbt.2	+	4	2369	c.2083C>T	c.(2083-2085)CCT>TCT	p.P695S	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	695							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TCTCCAAATTCCTCAGAGTCC	0.562										HNSCC(15;0.026)			46	9					0	0	0.002522	0	0
SLITRK4	139065	broad.mit.edu	37	X	142717680	142717680	+	Silent	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chrX:142717680C>T	uc004fbx.2	-	2	1621	c.1245G>A	c.(1243-1245)GTG>GTA	p.V415V	SLITRK4_uc004fby.2_Silent_p.V415V	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	415	Extracellular (Potential).|LRR 8.					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CTCCCTTAATCACTGTAATTT	0.393													53	7					0	0	0.003610	0	0
TAZ	6901	broad.mit.edu	37	X	153649022	153649022	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chrX:153649022C>T	uc004fkx.2	+	10	1029	c.725C>T	c.(724-726)CCC>CTC	p.P242L	TAZ_uc004fky.2_Missense_Mutation_p.P228L|TAZ_uc004fkz.2_RNA|TAZ_uc004fla.2_Missense_Mutation_p.P212L|TAZ_uc004flb.2_Missense_Mutation_p.P198L|TAZ_uc010nuy.2_Missense_Mutation_p.P246L|TAZ_uc004flc.3_Missense_Mutation_p.P212L	NM_000116	NP_000107	Q16635	TAZ_HUMAN	tafazzin isoform 1	242					cardiac muscle contraction|cardiac muscle tissue development|cardiolipin biosynthetic process|cristae formation|hemopoiesis|mitochondrial ATP synthesis coupled electron transport|mitochondrial respiratory chain complex I assembly|skeletal muscle tissue development	integral to membrane|mitochondrion	1-acylglycerophosphocholine O-acyltransferase activity				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ATCGGGAAGCCCTTCAGTGCC	0.647													23	9					0	0	0.006320	0	0
F8	2157	broad.mit.edu	37	X	154157053	154157053	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chrX:154157053C>T	uc004fmt.2	-	14	5183	c.5012G>A	c.(5011-5013)CGT>CAT	p.R1671H		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	1671					acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	AAGAGTAGTACGAGTTATTTC	0.408													48	7					0	0	0.003610	0	0
HNRNPUL2	221092	broad.mit.edu	37	11	62491837	62491838	+	Frame_Shift_Ins	INS	-	C	C			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:62491837_62491838insC	uc001nuw.2	-	2	792_793	c.599_600insG	c.(598-600)GTAfs	p.V200fs	HNRNPUL2_uc001nuu.1_RNA	NM_001079559	NP_001073027	Q1KMD3	HNRL2_HUMAN	heterogeneous nuclear ribonucleoprotein U-like	200	Glu-rich.				cell killing	nucleus	ATP binding|nucleic acid binding				0						GCTGTCTCTTTACCCCCCGCCG	0.495													9	158	---	---	---	---					
HNRNPUL2	221092	broad.mit.edu	37	11	62491838	62491839	+	Frame_Shift_Ins	INS	-	C	C			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:62491838_62491839insC	uc001nuw.2	-	2	791_792	c.598_599insG	c.(598-600)GTAfs	p.V200fs	HNRNPUL2_uc001nuu.1_RNA	NM_001079559	NP_001073027	Q1KMD3	HNRL2_HUMAN	heterogeneous nuclear ribonucleoprotein U-like	200	Glu-rich.				cell killing	nucleus	ATP binding|nucleic acid binding				0						CTGTCTCTTTACCCCCCGCCGC	0.500													21	148	---	---	---	---					
PVRL1	5818	broad.mit.edu	37	11	119535677	119535678	+	In_Frame_Ins	INS	-	CCT	CCT	rs137909701	by1000genomes	TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr11:119535677_119535678insCCT	uc001pwv.2	-	6	1505_1506	c.1333_1334insAGG	c.(1333-1335)GGC>GAGGGC	p.444_445insE	PVRL1_uc001pwu.1_Intron	NM_002855	NP_002846	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 isoform 1	444_445	Poly-Gly.|Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		CCCTCCACCGCcctcctcctcc	0.574													10	45	---	---	---	---					
ATF7IP	55729	broad.mit.edu	37	12	14577971	14577973	+	In_Frame_Del	DEL	TAT	-	-			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr12:14577971_14577973delTAT	uc001rbw.2	+	2	1280_1282	c.1122_1124delTAT	c.(1120-1125)GATATT>GAT	p.I376del	ATF7IP_uc010shs.1_In_Frame_Del_p.I376del|ATF7IP_uc001rbu.2_In_Frame_Del_p.I376del|ATF7IP_uc001rbv.1_In_Frame_Del_p.I376del|ATF7IP_uc001rbx.2_In_Frame_Del_p.I376del|ATF7IP_uc010sht.1_In_Frame_Del_p.I376del|ATF7IP_uc001rby.3_In_Frame_Del_p.I376del|ATF7IP_uc001rbz.1_In_Frame_Del_p.I376del|ATF7IP_uc001rca.2_In_Frame_Del_p.I376del|ATF7IP_uc001rcb.2_5'UTR	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	376	Glu-rich.				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						TAGAGGAAGATATTATCACAGAG	0.350													27	91	---	---	---	---					
IL32	9235	broad.mit.edu	37	16	3119304	3119305	+	Frame_Shift_Ins	INS	-	G	G	rs2981599		TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr16:3119304_3119305insG	uc002cto.2	+	6	864_865	c.653_654insG	c.(652-654)GACfs	p.D218fs	IL32_uc002ctk.2_Frame_Shift_Ins_p.D115fs|IL32_uc010uwp.1_Frame_Shift_Ins_p.D152fs|IL32_uc010btb.2_Frame_Shift_Ins_p.D162fs|IL32_uc002ctl.2_Frame_Shift_Ins_p.D172fs|IL32_uc002ctm.2_Frame_Shift_Ins_p.D172fs|IL32_uc002ctn.2_Frame_Shift_Ins_p.D172fs|IL32_uc002cts.3_Frame_Shift_Ins_p.D172fs|IL32_uc002ctp.2_Frame_Shift_Ins_p.D152fs|IL32_uc002ctq.2_Frame_Shift_Ins_p.D218fs|IL32_uc002ctr.2_Frame_Shift_Ins_p.D152fs|IL32_uc002ctt.2_Frame_Shift_Ins_p.D172fs|IL32_uc010uwr.1_Frame_Shift_Ins_p.D132fs|IL32_uc002ctu.2_Frame_Shift_Ins_p.D163fs	NM_004221	NP_004212	P24001	IL32_HUMAN	interleukin 32 isoform B	218					cell adhesion|defense response|immune response	extracellular space	cytokine activity			pancreas(1)	1						CCACGGGGGGACAAGGAGGAGC	0.574													10	206	---	---	---	---					
SALL3	27164	broad.mit.edu	37	18	76755055	76755055	+	Frame_Shift_Del	DEL	C	-	-			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr18:76755055delC	uc002lmt.2	+	2	3064	c.3064delC	c.(3064-3066)CAGfs	p.Q1022fs	SALL3_uc010dra.2_Intron	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	1022	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		TAATTTAAAACAGCACTTACT	0.522													37	27	---	---	---	---					
C20orf27	54976	broad.mit.edu	37	20	3735139	3735139	+	Frame_Shift_Del	DEL	G	-	-			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr20:3735139delG	uc002wji.1	-	5	558	c.329delC	c.(328-330)GCGfs	p.A110fs	C20orf27_uc002wjf.1_3'UTR|C20orf27_uc002wjh.1_Frame_Shift_Del_p.A135fs	NM_001039140	NP_001034229	Q9GZN8	CT027_HUMAN	hypothetical protein LOC54976	110											0						CTCTTTGTGCGCCGAGTACTC	0.642													19	63	---	---	---	---					
MED15	51586	broad.mit.edu	37	22	20920814	20920816	+	In_Frame_Del	DEL	CAG	-	-			TCGA-FS-A1ZS-06A-12D-A197-08	TCGA-FS-A1ZS-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c24feb7-7460-49db-b6f7-64ccf377311a	50ea367b-5ca1-4338-9fcf-0fd0db568b1a	g.chr22:20920814_20920816delCAG	uc002zsp.2	+	7	831_833	c.751_753delCAG	c.(751-753)CAGdel	p.Q262del	MED15_uc002zso.2_In_Frame_Del_p.Q191del|MED15_uc002zsq.2_In_Frame_Del_p.Q262del|MED15_uc010gso.2_In_Frame_Del_p.Q262del|MED15_uc002zsr.2_In_Frame_Del_p.Q236del|MED15_uc011ahs.1_In_Frame_Del_p.Q236del|MED15_uc002zss.2_In_Frame_Del_p.Q181del|MED15_uc011ahu.1_5'UTR	NM_001003891	NP_001003891	Q96RN5	MED15_HUMAN	mediator complex subunit 15 isoform a	262	Poly-Gln.		Missing.	Missing (in Ref. 3; BAB85034).	regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			skin(1)	1	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			acaacagcaacagcagcagcagc	0.315													8	56	---	---	---	---					
