Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OSBPL9	114883	broad.mit.edu	37	1	52250221	52250221	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr1:52250221G>A	uc001cst.2	+	20	1815	c.1796G>A	c.(1795-1797)GGG>GAG	p.G599E	OSBPL9_uc001css.2_Missense_Mutation_p.G604E|OSBPL9_uc001csx.2_RNA|OSBPL9_uc009vza.2_Missense_Mutation_p.G600E|OSBPL9_uc001csu.2_Missense_Mutation_p.G609E|OSBPL9_uc001csv.2_Missense_Mutation_p.G434E|OSBPL9_uc001csw.2_Missense_Mutation_p.G586E|OSBPL9_uc001csy.2_Missense_Mutation_p.G421E|OSBPL9_uc001csz.2_Missense_Mutation_p.G421E|OSBPL9_uc001cta.2_Missense_Mutation_p.G489E|OSBPL9_uc001ctb.2_Missense_Mutation_p.G384E	NM_024586	NP_078862	Q96SU4	OSBL9_HUMAN	oxysterol binding protein-like 9 isoform e	599					lipid transport		lipid binding			central_nervous_system(1)	1						CCCTTCTATGGGGGCAAGAAG	0.403000													19	45					0	0	0.010504	0	0
SLC1A7	6512	broad.mit.edu	37	1	53558324	53558324	+	Silent	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr1:53558324G>A	uc001cuy.2	-	7	1101	c.933C>T	c.(931-933)ATC>ATT	p.I311I	SLC1A7_uc001cux.2_5'Flank	NM_006671	NP_006662	O00341	EAA5_HUMAN	solute carrier family 1 (glutamate transporter),	311	Helical; (Potential).					integral to membrane|plasma membrane	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			ovary(2)|large_intestine(1)	3				Colorectal(1306;0.234)	L-Glutamic Acid(DB00142)	GCAGGGGCAGGATAAAGAGCC	0.597000													24	44					0	0	0.006320	0	0
C1orf175	374977	broad.mit.edu	37	1	55167796	55167796	+	Silent	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr1:55167796C>T	uc010ooe.1	+	20	3643	c.3319C>T	c.(3319-3321)CTG>TTG	p.L1107L	C1orf175_uc001cxq.2_RNA|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Silent_p.L625L|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA|C1orf175_uc009vzr.1_Silent_p.L309L	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	1107	HEAT 3.					integral to membrane	binding				0						CTGCATCAACCTGTATGGGAA	0.622000													15	22					0	0	0.007413	0	0
IL23R	149233	broad.mit.edu	37	1	67666516	67666516	+	Silent	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr1:67666516C>T	uc001ddo.2	+	5	673	c.588C>T	c.(586-588)GTC>GTT	p.V196V	IL23R_uc009waz.2_5'UTR|IL23R_uc001ddp.2_RNA|IL23R_uc010opi.1_RNA|IL23R_uc010opj.1_Intron|IL23R_uc010opk.1_Silent_p.V153V|IL23R_uc010opl.1_Intron|IL23R_uc010opm.1_RNA|IL23R_uc001ddq.2_Intron|IL23R_uc010opn.1_Silent_p.V41V|IL23R_uc001ddr.2_RNA|IL23R_uc010opo.1_Silent_p.V55V|IL23R_uc010opp.1_Intron|IL23R_uc010opq.1_Silent_p.V55V|IL23R_uc010opr.1_RNA|IL23R_uc010ops.1_5'UTR|IL23R_uc010opt.1_5'UTR|IL23R_uc010opu.1_5'UTR|IL23R_uc010opv.1_Silent_p.V55V|IL23R_uc010opw.1_Intron|IL23R_uc010opx.1_Intron|IL23R_uc010opy.1_5'UTR|IL23R_uc010opz.1_Intron|IL23R_uc010oqa.1_5'UTR|IL23R_uc010oqb.1_Silent_p.V55V|IL23R_uc010oqc.1_Intron|IL23R_uc010oqd.1_Intron|IL23R_uc010oqe.1_5'UTR|IL23R_uc010oqf.1_5'UTR|IL23R_uc010oqg.1_5'UTR|IL23R_uc010oqh.1_Intron	NM_144701	NP_653302	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor precursor	196	Extracellular (Potential).|Fibronectin type-III 1.				inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity				0						TGGTTTGGGTCCAAGCAGCAA	0.373000													39	77					0	0	0.014410	0	0
CLCA2	9635	broad.mit.edu	37	1	86916377	86916377	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr1:86916377G>A	uc001dlr.3	+	12	2278	c.2116G>A	c.(2116-2118)GGG>AGG	p.G706R		NM_006536	NP_006527	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2 precursor	706	Extracellular (Potential).				cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			ovary(1)|breast(1)|skin(1)	3		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		CTCTATTCCAGGGAGTCATGC	0.423000													54	91					0	0	0.014410	0	0
WDR3	10885	broad.mit.edu	37	1	118495284	118495284	+	Missense_Mutation	SNP	T	C	C			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr1:118495284T>C	uc010oxe.1	+	19	2216	c.2150T>C	c.(2149-2151)ATG>ACG	p.M717T	WDR3_uc001ehi.2_Intron	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	717						nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		GAAAGGGAGATGGTAAGAACT	0.448000													27	68					0	0	0.021022	0	0
FLG2	388698	broad.mit.edu	37	1	152328911	152328911	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr1:152328911G>A	uc001ezw.3	-	3	1424	c.1351C>T	c.(1351-1353)CAA>TAA	p.Q451*	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	451	Filaggrin 2.|Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCACAAGTTTGACCTGAGCCA	0.478000													104	94					0	0	0.014410	0	0
PGLYRP3	114771	broad.mit.edu	37	1	153270485	153270485	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr1:153270485G>A	uc001fbn.1	-	7	1026	c.973C>T	c.(973-975)CCT>TCT	p.P325S		NM_052891	NP_443123	Q96LB9	PGRP3_HUMAN	peptidoglycan recognition protein 3 precursor	325					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4	all_lung(78;3.35e-32)|Lung NSC(65;1.22e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCCTGCCCAGGGGACAGGATG	0.597000													58	261					0	0	0.014410	0	0
RYR2	6262	broad.mit.edu	37	1	237664122	237664122	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr1:237664122G>A	uc001hyl.1	+	21	2435	c.2315G>A	c.(2314-2316)GGA>GAA	p.G772E		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	772	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CGAATTAATGGACAACCTGTT	0.403000													41	107					0	0	0.009718	0	0
TUBB8	347688	broad.mit.edu	37	10	93851	93851	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr10:93851C>T	uc001ifi.2	-	4	481	c.481G>A	c.(481-483)GAC>AAC	p.D161N	TUBB8_uc009xhe.2_Missense_Mutation_p.D124N|TUBB8_uc010pzs.1_Missense_Mutation_p.D89N	NM_177987	NP_817124	Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 isoform 1	161					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		ATGATCCTGTCTGGGTACTCC	0.597000													33	75					0	0	0.014410	0	0
NRP1	8829	broad.mit.edu	37	10	33502319	33502319	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr10:33502319C>T	uc001iwx.3	-	9	2132	c.1609G>A	c.(1609-1611)GCG>ACG	p.A537T	NRP1_uc001iwv.3_Missense_Mutation_p.A537T|NRP1_uc009xlz.2_Missense_Mutation_p.A537T|NRP1_uc001iww.3_Missense_Mutation_p.A356T|NRP1_uc001iwy.3_Missense_Mutation_p.A537T|NRP1_uc001iwz.2_Missense_Mutation_p.A537T|NRP1_uc001ixa.2_Missense_Mutation_p.A537T|NRP1_uc001ixb.1_Missense_Mutation_p.A537T|NRP1_uc001ixc.1_Missense_Mutation_p.A537T	NM_003873	NP_003864	O14786	NRP1_HUMAN	neuropilin 1 isoform a	537	Extracellular (Potential).|F5/8 type C 2.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)	CTCACCTTCGCCTTGCGTTTG	0.527000													98	54					0	0	0.014410	0	0
TSPAN14	81619	broad.mit.edu	37	10	82272022	82272022	+	Silent	SNP	T	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr10:82272022T>A	uc001kcj.3	+	6	680	c.573T>A	c.(571-573)CCT>CCA	p.P191P	TSPAN14_uc009xss.2_Silent_p.P68P|TSPAN14_uc001kci.3_Silent_p.P174P	NM_030927	NP_112189	Q8NG11	TSN14_HUMAN	tetraspanin 14 isoform 1	191						integral to membrane				ovary(1)|central_nervous_system(1)	2			Colorectal(32;0.229)			TGCCAGATCCTGCGGTGAGTT	0.597000													21	6					0	0	0.016522	0	0
STAMBPL1	57559	broad.mit.edu	37	10	90732959	90732959	+	Silent	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr10:90732959G>A	uc010qmx.1	+	11	1698	c.1275G>A	c.(1273-1275)GGG>GGA	p.G425G	ACTA2_uc001kfq.2_Intron|FAS_uc010qna.1_RNA	NM_020799	NP_065850	Q96FJ0	STALP_HUMAN	STAM binding protein-like 1	Error:Variant_position_missing_in_Q96FJ0_after_alignment							metal ion binding|metallopeptidase activity|protein binding			ovary(1)	1		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)		TCCTTTCTGGGATAATTTCTG	0.433000													49	26					0	0	0.014410	0	0
PLCE1	51196	broad.mit.edu	37	10	95995871	95995871	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr10:95995871G>A	uc001kjk.2	+	7	3048	c.2414G>A	c.(2413-2415)CGA>CAA	p.R805Q	PLCE1_uc010qnx.1_Missense_Mutation_p.R805Q|PLCE1_uc001kjm.2_Missense_Mutation_p.R497Q	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	805					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				GATAAAAGCCGATGGCAGTAA	0.463000													9	4					0	0	0.008291	0	0
KCNQ1	3784	broad.mit.edu	37	11	2592606	2592606	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr11:2592606G>A	uc001lwn.2	+	4	764	c.656G>A	c.(655-657)GGG>GAG	p.G219E	KCNQ1_uc009ydp.1_Intron|KCNQ1_uc001lwo.2_Missense_Mutation_p.G92E	NM_000218	NP_000209	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like	219	Extracellular (Potential).				blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			ovary(1)	1		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	GGCTCCAAGGGGCAGGTGTTT	0.677000													30	63					0	0	0.017118	0	0
CCKBR	887	broad.mit.edu	37	11	6291015	6291015	+	Missense_Mutation	SNP	A	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr11:6291015A>T	uc001mcp.2	+	2	461	c.268A>T	c.(268-270)AAT>TAT	p.N90Y	CCKBR_uc001mcq.2_Missense_Mutation_p.N18Y|CCKBR_uc001mcr.2_Missense_Mutation_p.N90Y|CCKBR_uc001mcs.2_Missense_Mutation_p.N90Y	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	90	Helical; Name=2; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	GACTGTCACCAATGCCTTCCT	0.552000													50	117					0	0	0.014410	0	0
SLC22A24	283238	broad.mit.edu	37	11	62911066	62911066	+	Silent	SNP	A	G	G			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr11:62911066A>G	uc009yop.2	-	1	628	c.186T>C	c.(184-186)AAT>AAC	p.N62N		NM_001136506	NP_001129978			solute carrier family 22, member 24												0						TCCCGGTATCATTGTCAGACA	0.522000													8	20					0	0	0.006214	0	0
SLC22A11	55867	broad.mit.edu	37	11	64338456	64338456	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr11:64338456C>T	uc001oai.2	+	10	1969	c.1595C>T	c.(1594-1596)TCA>TTA	p.S532L	SLC22A11_uc001oaj.2_Missense_Mutation_p.S463L|SLC22A11_uc009ypq.2_Missense_Mutation_p.S424L	NM_018484	NP_060954	Q9NSA0	S22AB_HUMAN	solute carrier family 22 member 11	532	Cytoplasmic (Potential).				urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2					Probenecid(DB01032)	TCTAGGAAATCAACAGCAGCC	0.478000													32	63					0	0	0.005524	0	0
MMP12	4321	broad.mit.edu	37	11	102745631	102745631	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr11:102745631C>T	uc001phk.2	-	1	82	c.37G>A	c.(37-39)GCT>ACT	p.A13T		NM_002426	NP_002417	P39900	MMP12_HUMAN	matrix metalloproteinase 12 preproprotein	13					positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	GCTCCAGAAGCAGTGGCCTGC	0.408000													5	10					0	0	0.003080	0	0
TEAD4	7004	broad.mit.edu	37	12	3147221	3147221	+	Missense_Mutation	SNP	A	G	G			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr12:3147221A>G	uc010sej.1	+	11	1259	c.982A>G	c.(982-984)ACC>GCC	p.T328A	TEAD4_uc010sek.1_Missense_Mutation_p.T285A|TEAD4_uc001qln.2_Missense_Mutation_p.T200A	NM_003213	NP_003204	Q15561	TEAD4_HUMAN	TEA domain family member 4 isoform 1	329					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			CATGATCATCACCTGCTCCAC	0.587000													21	34					0	0	0.012319	0	0
KCNA1	3736	broad.mit.edu	37	12	5021217	5021217	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr12:5021217G>A	uc001qnh.2	+	2	1778	c.673G>A	c.(673-675)GAA>AAA	p.E225K		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	225	Helical; Name=Segment S2; (Potential).				synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CTTCATCGTGGAAACGCTGTG	0.512000													42	14					0	0	0.009718	0	0
ACSS3	79611	broad.mit.edu	37	12	81503432	81503432	+	Silent	SNP	T	C	C			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr12:81503432T>C	uc001szl.1	+	2	496	c.405T>C	c.(403-405)AGT>AGC	p.S135S	ACSS3_uc001szm.1_Silent_p.S134S	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	135						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						TCTATGACAGTCCTGTTACAA	0.313000													43	15					0	0	0.014410	0	0
FBXW8	26259	broad.mit.edu	37	12	117461999	117461999	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr12:117461999C>T	uc001twg.1	+	9	1497	c.1415C>T	c.(1414-1416)TCC>TTC	p.S472F	FBXW8_uc001twf.1_Missense_Mutation_p.S406F|FBXW8_uc009zwp.1_RNA	NM_153348	NP_699179	Q8N3Y1	FBXW8_HUMAN	F-box and WD repeat domain containing 8 isoform	472							protein binding			ovary(2)|pancreas(1)	3	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0353)		CTGTCGCTCTCCGCCCATCAG	0.577000													43	11					0	0	0.014410	0	0
LOC374491	374491	broad.mit.edu	37	13	25161457	25161457	+	RNA	SNP	G	A	A	rs1851732	by1000genomes	TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr13:25161457G>A	uc001upm.2	+	8		c.981G>A			LOC374491_uc001upn.2_RNA|LOC374491_uc001upo.2_RNA					Homo sapiens mRNA; cDNA DKFZp434J0717 (from clone DKFZp434J0717).												0						TTATTTATTCGATTCGTGGTA	0.378000													4	42					0	0	0.001168	0	0
PDS5B	23047	broad.mit.edu	37	13	33306319	33306319	+	Silent	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr13:33306319G>A	uc010abf.2	+	20	2363	c.2205G>A	c.(2203-2205)GCG>GCA	p.A735A	PDS5B_uc010abg.2_RNA	NM_015032	NP_055847	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog	735					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			ovary(2)|lung(1)|pancreas(1)	4		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		GTATCCATGCGATATTTTCTA	0.313000													15	30					0	0	0.006122	0	0
THSD1P1	374500	broad.mit.edu	37	13	52865661	52865661	+	RNA	SNP	C	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr13:52865661C>A	uc001vgm.1	-	1		c.20G>T								Homo sapiens cDNA FLJ14630 fis, clone NT2RP2000459.												0						AAGGATGACACAATTGAATGA	0.289000													9	39					0.000308642	0.000326065	0.003163	1	0
LTBP2	4053	broad.mit.edu	37	14	74972782	74972782	+	Silent	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr14:74972782C>T	uc001xqa.2	-	28	4533	c.4146G>A	c.(4144-4146)CAG>CAA	p.Q1382Q		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	1382	EGF-like 16; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		AGTGCCCCTCCTGGGCATCGT	0.627000													62	63					0	0	0.014410	0	0
EML5	161436	broad.mit.edu	37	14	89093244	89093244	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr14:89093244C>T	uc001xxg.2	-	35	4864	c.4678G>A	c.(4678-4680)GGG>AGG	p.G1560R	EML5_uc001xxf.2_Missense_Mutation_p.G347R|EML5_uc001xxh.1_Missense_Mutation_p.G691R	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1552						cytoplasm|microtubule				ovary(3)	3						CTCAGTAGCCCTTTTTTGCTA	0.468000													30	34					0	0	0.010818	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102476715	102476715	+	Silent	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr14:102476715C>T	uc001yks.2	+	31	6488	c.6324C>T	c.(6322-6324)ATC>ATT	p.I2108I		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	2108					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						GAGAGAGAATCCAGAAGATAA	0.463000													26	30					0	0	0.009535	0	0
GABRB3	2562	broad.mit.edu	37	15	26806278	26806278	+	Missense_Mutation	SNP	C	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr15:26806278C>A	uc001zaz.2	-	8	1023	c.881G>T	c.(880-882)CGG>CTG	p.R294L	GABRB3_uc010uae.1_Missense_Mutation_p.R209L|GABRB3_uc001zba.2_Missense_Mutation_p.R294L|GABRB3_uc001zbb.2_Missense_Mutation_p.R350L	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	294					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CAAGGTCTCCCGAAGGTGGGT	0.478000													5	125					1.23904e-05	1.31963e-05	0.014758	1	0
GABRA5	2558	broad.mit.edu	37	15	27128562	27128562	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr15:27128562C>T	uc001zbd.1	+	7	694	c.355C>T	c.(355-357)CCT>TCT	p.P119S	GABRB3_uc001zbb.2_Intron	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	119	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GCAGCGCCTCCCTCTCAACAA	0.532000													59	55					0	0	0.014410	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42373218	42373218	+	Silent	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr15:42373218G>A	uc001zox.2	-	12	1166	c.1071C>T	c.(1069-1071)TTC>TTT	p.F357F		NM_178034	NP_828848	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD	357	PLA2c.				phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			large_intestine(1)|skin(1)	2		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		AGATGCCACTGAAGTAGGTCA	0.612000													19	19					0	0	0.012319	0	0
MAP2K1	5604	broad.mit.edu	37	15	66729162	66729162	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr15:66729162C>T	uc010bhq.2	+	3	845	c.370C>T	c.(370-372)CCG>TCG	p.P124S	MAP2K1_uc010ujp.1_Missense_Mutation_p.P102S	NM_002755	NP_002746	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	124	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						GTGCAACTCTCCGTACATCGT	0.507000									Cardiofaciocutaneous_syndrome				22	54					0	0	0.018920	0	0
CCDC64B	146439	broad.mit.edu	37	16	3080465	3080465	+	Silent	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr16:3080465C>T	uc002ctf.3	-	4	792	c.747G>A	c.(745-747)CGG>CGA	p.R249R	CCDC64B_uc002cte.3_Silent_p.R42R|CCDC64B_uc010bta.1_3'UTR	NM_001103175	NP_001096645	A1A5D9	BICR2_HUMAN	coiled-coil domain containing 64B	249	Potential.										0						GGCTGTGCTCCCGCCGCTCCC	0.652000													13	9					0	0	0.004007	0	0
NLRC5	84166	broad.mit.edu	37	16	57060787	57060787	+	Silent	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr16:57060787C>T	uc002ekk.1	+	6	2157	c.1932C>T	c.(1930-1932)TTC>TTT	p.F644F	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Silent_p.F449F|NLRC5_uc002ekl.2_Silent_p.F449F|NLRC5_uc002ekm.2_Silent_p.F449F|NLRC5_uc010ccr.1_RNA	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	644					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				TCCACAATTTCCCACTGACCT	0.587000													70	68					0	0	0.014410	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77353946	77353946	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr16:77353946C>T	uc002ffc.3	-	16	2751	c.2332G>A	c.(2332-2334)GAA>AAA	p.E778K	ADAMTS18_uc010chc.1_Missense_Mutation_p.E366K|ADAMTS18_uc002ffe.1_Missense_Mutation_p.E474K	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	778	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						TCCTGGATTTCGATGCTTCGG	0.522000													18	40					0	0	0.012319	0	0
FBXO31	79791	broad.mit.edu	37	16	87417077	87417077	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr16:87417077G>A	uc002fjw.2	-	1	318	c.274C>T	c.(274-276)CAG>TAG	p.Q92*	FBXO31_uc010vot.1_Intron	NM_024735	NP_079011	Q5XUX0	FBX31_HUMAN	F-box protein 31	92	F-box.				cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0272)		GTGCAGACCTGGGCCAAGCTG	0.507000													5	7					0	0	0.001984	0	0
USP6	9098	broad.mit.edu	37	17	5041493	5041493	+	Missense_Mutation	SNP	G	A	A	rs145087393	byFrequency	TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr17:5041493G>A	uc002gau.1	+	21	3233	c.1003G>A	c.(1003-1005)GAT>AAT	p.D335N	USP6_uc002gav.1_Missense_Mutation_p.D335N|USP6_uc010ckz.1_5'UTR|uc002gbd.2_5'Flank	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	335					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						GGCCATGAACGATGACACCGT	0.577000			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								55	76					0	0	0.014410	0	0
MYH8	4626	broad.mit.edu	37	17	10310124	10310124	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr17:10310124C>T	uc002gmm.2	-	19	2149	c.2054G>A	c.(2053-2055)GGG>GAG	p.G685E	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	685	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TTCCATTGCCCCTAAAAATAT	0.418000									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				11	16					0	0	0.008291	0	0
DNAH9	1770	broad.mit.edu	37	17	11840675	11840675	+	Missense_Mutation	SNP	G	A	A	rs148626653		TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr17:11840675G>A	uc002gne.2	+	66	12564	c.12496G>A	c.(12496-12498)GAT>AAT	p.D4166N	DNAH9_uc010coo.2_Missense_Mutation_p.D3384N|DNAH9_uc002gnf.2_Missense_Mutation_p.D478N	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	4166					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TCAGTACATCGATGCTGAGCT	0.547000													24	97					0	0	0.006320	0	0
Unknown	0	broad.mit.edu	37	17	21731075	21731075	+	Missense_Mutation	SNP	T	G	G	rs111568648		TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr17:21731075T>G	uc002gyy.3	+	2	502	c.377T>G	c.(376-378)CTG>CGG	p.L126R						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;																		GGCAAGCAGCTGGAAGATGGC	0.537000													3	65					0	0	0.004672	0	0
CDK12	51755	broad.mit.edu	37	17	37665992	37665992	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr17:37665992C>T	uc010cvv.2	+	7	3230	c.2644C>T	c.(2644-2646)CGG>TGG	p.R882W	CDK12_uc010wef.1_Missense_Mutation_p.R881W|CDK12_uc002hrw.3_Missense_Mutation_p.R882W	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	882	Protein kinase.				mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity	p.R882L(1)		ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						TGGACTTGCTCGGCTCTATAA	0.289000										TCGA Ovarian(9;0.13)			41	72					0	0	0.014410	0	0
DSG4	147409	broad.mit.edu	37	18	28971146	28971146	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr18:28971146G>A	uc002kwq.2	+	7	925	c.790G>A	c.(790-792)GAT>AAT	p.D264N	DSG4_uc002kwr.2_Missense_Mutation_p.D264N	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	264	Cadherin 2.|Extracellular (Potential).		Missing (in LAH1).		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AGACGTCAACGATAATTTCCC	0.388000													52	48					0	0	0.014410	0	0
DSG4	147409	broad.mit.edu	37	18	28991408	28991408	+	Silent	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr18:28991408G>A	uc002kwq.2	+	15	2487	c.2352G>A	c.(2350-2352)TCG>TCA	p.S784S	DSG4_uc002kwr.2_Silent_p.S803S	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	784	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GCTACTTCTCGGAGGTAATGC	0.408000													45	31					0	0	0.014410	0	0
DSG3	1830	broad.mit.edu	37	18	29054229	29054229	+	Silent	SNP	C	T	T	rs142612259	byFrequency	TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr18:29054229C>T	uc002kws.2	+	15	2356	c.2247C>T	c.(2245-2247)TTC>TTT	p.F749F	DSG3_uc002kwt.2_Silent_p.F31F	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	749	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CTTCAGGATTCGGAGCAGCCA	0.537000													25	31					0	0	0.004656	0	0
ZCCHC2	54877	broad.mit.edu	37	18	60242215	60242215	+	Silent	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr18:60242215C>T	uc002lip.3	+	13	2901	c.2901C>T	c.(2899-2901)GGC>GGT	p.G967G	ZCCHC2_uc002lio.2_RNA|ZCCHC2_uc002liq.2_Silent_p.G437G	NM_017742	NP_060212	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	967					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			lung(1)|prostate(1)	2						ACACCCCAGGCCCTGCCCCGA	0.617000													28	64					0	0	0.009535	0	0
MUC16	94025	broad.mit.edu	37	19	9073897	9073897	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:9073897C>T	uc002mkp.2	-	3	13753	c.13549G>A	c.(13549-13551)GAG>AAG	p.E4517K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4519	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCCAGTATCTCATTTGATGGA	0.433000													34	49					0	0	0.008740	0	0
ZNF208	7757	broad.mit.edu	37	19	22155896	22155896	+	Missense_Mutation	SNP	A	C	C			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:22155896A>C	uc002nqp.2	-	5	1789	c.1640T>G	c.(1639-1641)ATT>AGT	p.I547S	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGAGACCTTAATAAAGGTTTT	0.398000													3	93					0	0	0.001168	0	0
ZNF792	126375	broad.mit.edu	37	19	35449284	35449284	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:35449284C>T	uc002nxh.1	-	4	1862	c.1475G>A	c.(1474-1476)AGC>AAC	p.S492N		NM_175872	NP_787068	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	492	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GCTATTGAGGCTGGAGCTCTG	0.493000													61	30					0	0	0.014410	0	0
MEGF8	1954	broad.mit.edu	37	19	42839252	42839252	+	Silent	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:42839252G>A	uc002otl.3	+	4	1259	c.624G>A	c.(622-624)GAG>GAA	p.E208E	MEGF8_uc002otm.3_5'Flank	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	208	Extracellular (Potential).					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				ACCTGTGGGAGAACCAGGGGG	0.632000													13	15					0	0	0.004990	0	0
ZNF221	7638	broad.mit.edu	37	19	44470724	44470724	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:44470724C>T	uc002oxx.2	+	6	1398	c.1070C>T	c.(1069-1071)TCC>TTC	p.S357F	ZNF221_uc010ejb.1_Missense_Mutation_p.S357F|ZNF221_uc010xws.1_Missense_Mutation_p.S357F	NM_013359	NP_037491	Q9UK13	ZN221_HUMAN	zinc finger protein 221	357	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Prostate(69;0.0352)				AATAGTCATTCCATGGTCCAC	0.413000													102	81					0	0	0.014410	0	0
CCDC8	83987	broad.mit.edu	37	19	46914959	46914959	+	Missense_Mutation	SNP	T	C	C			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:46914959T>C	uc002pep.2	-	1	1961	c.1109A>G	c.(1108-1110)GAG>GGG	p.E370G		NM_032040	NP_114429	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	370						plasma membrane				ovary(3)	3				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		AGCTGGGGCCTCTGCCCTCTG	0.607000													5	295					0	0	0.001984	0	0
PTGIR	5739	broad.mit.edu	37	19	47124917	47124917	+	Missense_Mutation	SNP	T	G	G			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:47124917T>G	uc002pex.2	-	3	894	c.781A>C	c.(781-783)ACC>CCC	p.T261P		NM_000960	NP_000951	P43119	PI2R_HUMAN	prostaglandin I2 (prostacyclin) receptor (IP)	261	Extracellular (Potential).				cell-cell signaling|G-protein signaling, coupled to cyclic nucleotide second messenger|platelet activation	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity				0		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000327)|all cancers(93;0.000641)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0331)	Dinoprost Tromethamine(DB01160)|Dinoprostone(DB00917)|Epoprostenol(DB01240)|Iloprost(DB01088)|Misoprostol(DB00929)	ACAGCCTGGGTGAAGCAGCGG	0.637000													29	16					0	0	0.013726	0	0
SIGLEC16	400709	broad.mit.edu	37	19	50473221	50473221	+	RNA	SNP	T	C	C	rs117072442	by1000genomes	TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:50473221T>C	uc002prf.2	+	2		c.240T>C			SIGLEC16_uc010ybj.1_5'Flank|uc010ybk.1_5'Flank	NR_002825				Homo sapiens cDNA FLJ50062 complete cds, highly similar to Sialic acid-binding Ig-like lectin 11 precursor.												0						GTTCAAAGGATGGACCAGCCC	0.602000													5	40					0	0	0.001168	0	0
ZNF761	388561	broad.mit.edu	37	19	53959186	53959187	+	Missense_Mutation	DNP	CC	GT	GT			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:53959186_53959187CC>GT	uc010eqp.2	+	7	1883_1884	c.1425_1426CC>GT	c.(1423-1428)TTCCGT>TTGTGT	p.475_476FR>LC	ZNF761_uc010ydy.1_Missense_Mutation_p.421_422FR>LC|ZNF761_uc002qbt.1_Missense_Mutation_p.421_422FR>LC	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	475_476	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		ACAAAGCTTTCCGTTTCAAATC	0.421000													38	72					0	0	0.004672	0	0
KIR3DL3	115653	broad.mit.edu	37	19	55239263	55239263	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:55239263C>T	uc002qgu.1	+	4	560	c.542C>T	c.(541-543)TCC>TTC	p.S181F	KIR2DL3_uc002qgv.2_Intron	NM_153443	NP_703144	Q8N743	KI3L3_HUMAN	killer cell immunoglobulin-like receptor, three	181	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(193;0.0192)		GTCAACTATTCCATGGGTCCC	0.572000													69	56					0	0	0.014410	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55333038	55333038	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:55333038C>T	uc002qhk.3	+	5	737	c.674C>T	c.(673-675)TCT>TTT	p.S225F	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Missense_Mutation_p.S167F|KIR3DL1_uc010esf.2_Missense_Mutation_p.S130F|KIR3DL1_uc010yfo.1_Missense_Mutation_p.S167F|KIR3DL1_uc002qhl.3_Missense_Mutation_p.S225F	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	225	Extracellular (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		GAGAAACCTTCTCTCTCAGCC	0.557000													114	88					0	0	0.014410	0	0
MYT1L	23040	broad.mit.edu	37	2	1926514	1926514	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr2:1926514C>T	uc002qxe.2	-	10	1854	c.1027G>A	c.(1027-1029)GAG>AAG	p.E343K	MYT1L_uc002qxd.2_Missense_Mutation_p.E343K|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	343					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GGGTTGGTCTCACTGAGCTTC	0.557000													7	37					0	0	0.003080	0	0
KYNU	8942	broad.mit.edu	37	2	143790836	143790836	+	Silent	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr2:143790836C>T	uc002tvl.2	+	12	1117	c.987C>T	c.(985-987)TTC>TTT	p.F329F	KYNU_uc010fnm.2_Silent_p.F329F	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a	329					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	TCTGTGGATTCCGAATTTCAA	0.373000													139	131					0	0	0.014410	0	0
CHN1	1123	broad.mit.edu	37	2	175742832	175742832	+	Silent	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr2:175742832G>A	uc002uji.2	-	6	815	c.285C>T	c.(283-285)TTC>TTT	p.F95F	CHN1_uc010zeq.1_Silent_p.F95F|CHN1_uc002ujj.2_Intron	NM_001822	NP_001813	P15882	CHIN_HUMAN	chimerin (chimaerin) 1 isoform a	95	SH2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.226)			AGTAGAGCCTGAAGTTTCTGG	0.383000			T	TAF15	extraskeletal myxoid chondrosarcoma								17	10					0	0	0.014323	0	0
TTN	7273	broad.mit.edu	37	2	179517255	179517255	+	Silent	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr2:179517255C>T	uc010zfg.1	-	156	31979	c.31755G>A	c.(31753-31755)CCG>CCA	p.P10585P	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc010fre.1_Intron|TTN_uc002umw.1_5'Flank|TTN_uc002umx.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11512							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAACTTCTTTCGGAGCCTCTG	0.373000													26	67					0	0	0.013726	0	0
UGT1A10	54575	broad.mit.edu	37	2	234545533	234545533	+	Missense_Mutation	SNP	C	T	T	rs145610800		TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr2:234545533C>T	uc002vur.2	+	1	411	c.365C>T	c.(364-366)TCG>TTG	p.S122L	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Missense_Mutation_p.S122L	NM_019075	NP_061948	Q9HAW8	UD110_HUMAN	UDP glycosyltransferase 1 family, polypeptide	122					flavone metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding			ovary(2)|skin(1)	3		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		TTATTTTTTTCGCATTGCAGG	0.363000													17	119					0	0	0.012319	0	0
SPEF1	25876	broad.mit.edu	37	20	3759160	3759160	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr20:3759160C>T	uc002wjj.2	-	6	679	c.511G>A	c.(511-513)GCG>ACG	p.A171T		NM_015417	NP_056232	Q9Y4P9	SPEF1_HUMAN	calponin-homology and microtubule-associated	171						cilium axoneme|cytoplasm|cytoskeleton					0						CGGTTATACGCTGGAGGCCGA	0.672000													10	5					0	0	0.010729	0	0
C20orf185	359710	broad.mit.edu	37	20	31656748	31656749	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr20:31656748_31656749GG>AA	uc002wym.1	+	10	1118_1119	c.1118_1119GG>AA	c.(1117-1119)GGG>GAA	p.G373E		NM_182658	NP_872599	P59826	LPLC3_HUMAN	antimicrobial peptide RYA3 precursor	373					innate immune response	cytoplasm|extracellular region	lipid binding|protein binding			ovary(4)	4						GTCCCTAAGGGGACCCCTGAAT	0.594000													27	66					0	0	0.004672	0	0
PTPRT	11122	broad.mit.edu	37	20	40877386	40877386	+	Silent	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr20:40877386G>A	uc002xkg.2	-	14	2437	c.2253C>T	c.(2251-2253)ATC>ATT	p.I751I	PTPRT_uc010ggj.2_Silent_p.I770I	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	751	Helical; (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GGAGGCCAGCGATCACGCCAG	0.552000													19	49					0	0	0.014323	0	0
Unknown	0	broad.mit.edu	37	20	56063732	56063732	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr20:56063732G>A	uc010zzl.1	-	1	352	c.352C>T	c.(352-354)CCT>TCT	p.P118S		NM_001008735	NP_001008735			high-mobility group box 1-like 1																		GACAGGCCAGGATGTTCTCCT	0.488000													69	56					0	0	0.014410	0	0
UCKL1	54963	broad.mit.edu	37	20	62572210	62572210	+	Splice_Site	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr20:62572210C>T	uc010gkn.2	-	11	1160	c.1117_splice	c.e11-1	p.D373_splice	UCKL1_uc002yhj.2_Splice_Site_p.D16_splice|UCKL1_uc011abm.1_Splice_Site_p.D358_splice|UCKL1_uc011abn.1_Splice_Site	NM_017859	NP_060329	Q9NWZ5	UCKL1_HUMAN	uridine-cytidine kinase 1-like 1						interspecies interaction between organisms	endoplasmic reticulum|nucleus	ATP binding|phosphotransferase activity, alcohol group as acceptor|protein binding|uridine kinase activity				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					CGACGCAGTCCTGTGGGGTGC	0.682000													31	22					0	0	0.006999	0	0
SH3BP1	23616	broad.mit.edu	37	22	38041502	38041502	+	Missense_Mutation	SNP	G	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr22:38041502G>T	uc003ati.2	+	10	1020	c.909G>T	c.(907-909)GAG>GAT	p.E303D	SH3BP1_uc003atg.1_RNA|SH3BP1_uc011anl.1_Missense_Mutation_p.E303D|SH3BP1_uc003ath.1_Missense_Mutation_p.E303D|SH3BP1_uc003atj.1_Missense_Mutation_p.E239D|SH3BP1_uc003atk.1_Missense_Mutation_p.E217D|uc003atl.1_Intron	NM_018957	NP_061830	Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1	303	Rho-GAP.				signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					TGCTTTCTGAGGGCATGAAGG	0.647000													30	59					1.42033e-22	1.59029e-22	0.019004	1	0
ZFYVE20	64145	broad.mit.edu	37	3	15115903	15115903	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr3:15115903G>A	uc003bzm.1	-	14	2355	c.1741C>T	c.(1741-1743)CCA>TCA	p.P581S	ZFYVE20_uc010hek.1_Missense_Mutation_p.P581S	NM_022340	NP_071735	Q9H1K0	RBNS5_HUMAN	FYVE-finger-containing Rab5 effector protein	581	Necessary for the interaction with EHD1.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			skin(2)	2						GTGCTGCTTGGAACTGGGGAA	0.592000													19	11					0	0	0.012319	0	0
ZNF197	10168	broad.mit.edu	37	3	44684223	44684223	+	Missense_Mutation	SNP	G	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr3:44684223G>T	uc003cnm.2	+	6	1807	c.1601G>T	c.(1600-1602)GGG>GTG	p.G534V	ZNF197_uc003cnn.2_Intron|ZNF197_uc003cno.2_Intron|ZNF197_uc003cnp.2_Intron	NM_006991	NP_008922	O14709	ZN197_HUMAN	zinc finger protein 197 isoform 1	534					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		ATCCACTCTGGGGAAAAACCC	0.433000													7	93					2.52707e-12	2.75872e-12	0.006214	1	0
COL7A1	1294	broad.mit.edu	37	3	48622192	48622192	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr3:48622192C>T	uc003ctz.2	-	34	4023	c.4022G>A	c.(4021-4023)GGA>GAA	p.G1341E		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1341	Triple-helical region.|Interrupted collagenous region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCCTCGAGGTCCTCGCTCTCC	0.667000													14	50					0	0	0.004990	0	0
CP	1356	broad.mit.edu	37	3	148924059	148924059	+	Silent	SNP	C	T	T	rs142503847		TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr3:148924059C>T	uc003ewy.3	-	6	1357	c.1104G>A	c.(1102-1104)GGG>GGA	p.G368G	CP_uc011bnr.1_RNA|CP_uc003ewx.3_Silent_p.G149G|CP_uc003ewz.2_Silent_p.G368G|CP_uc010hvf.1_Silent_p.G94G	NM_000096	NP_000087	P00450	CERU_HUMAN	ceruloplasmin precursor	368					cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	TAACATGCTTCCCACGGATAT	0.423000													59	53					0	0	0.014410	0	0
MME	4311	broad.mit.edu	37	3	154861348	154861348	+	Silent	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr3:154861348G>A	uc010hvr.1	+	13	1516	c.1305G>A	c.(1303-1305)GAG>GAA	p.E435E	MME_uc003fab.1_Silent_p.E435E|MME_uc003fac.1_Silent_p.E435E|MME_uc003fad.1_Silent_p.E435E|MME_uc003fae.1_Silent_p.E435E	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	435	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	TTGCTGGAGAGAGTAAACATG	0.403000													28	112					0	0	0.005524	0	0
KNG1	3827	broad.mit.edu	37	3	186459342	186459342	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr3:186459342C>T	uc011bsa.1	+	10	1369	c.1157C>T	c.(1156-1158)TCA>TTA	p.S386L	KNG1_uc003fqr.2_Missense_Mutation_p.S386L	NM_001102416	NP_001095886	P01042	KNG1_HUMAN	kininogen 1 isoform 1	386					blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			skin(1)	1	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	CCAGGTTTTTCACCTTTCCGA	0.383000													39	27					0	0	0.014410	0	0
LSG1	55341	broad.mit.edu	37	3	194379705	194379705	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr3:194379705G>A	uc003fui.2	-	7	1055	c.740C>T	c.(739-741)CCC>CTC	p.P247L		NM_018385	NP_060855	Q9H089	LSG1_HUMAN	large subunit GTPase 1	247					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity				0	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		ACCATTCAGGGGAATGGCTCC	0.458000													48	161					0	0	0.014410	0	0
CORIN	10699	broad.mit.edu	37	4	47663875	47663875	+	Splice_Site	SNP	T	C	C			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr4:47663875T>C	uc003gxm.2	-	12	1683	c.1590_splice	c.e12-1	p.R530_splice	CORIN_uc011bzf.1_Splice_Site_p.R391_splice|CORIN_uc011bzg.1_Splice_Site_p.R463_splice|CORIN_uc011bzh.1_Splice_Site_p.R493_splice|CORIN_uc011bzi.1_Intron	NM_006587	NP_006578	Q9Y5Q5	CORIN_HUMAN	corin						peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			ovary(1)|central_nervous_system(1)	2						CACAATGCCCTAGATGAACAA	0.408000													4	17					0	0	0.001168	0	0
MMRN1	22915	broad.mit.edu	37	4	90856722	90856722	+	Missense_Mutation	SNP	A	G	G			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr4:90856722A>G	uc003hst.2	+	6	1962	c.1891A>G	c.(1891-1893)AAG>GAG	p.K631E	MMRN1_uc010iku.2_Intron|MMRN1_uc011cds.1_Missense_Mutation_p.K373E	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	631	Potential.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		AATGGACAATAAGATGGACAA	0.363000													4	96					0	0	0.009096	0	0
EDNRA	1909	broad.mit.edu	37	4	148460990	148460990	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr4:148460990G>A	uc003iky.2	+	6	1614	c.922G>A	c.(922-924)GTT>ATT	p.V308I	EDNRA_uc011cid.1_Missense_Mutation_p.V83I|EDNRA_uc010ipf.1_RNA|EDNRA_uc010ipg.1_Missense_Mutation_p.V199I	NM_001957	NP_001948	P25101	EDNRA_HUMAN	endothelin receptor type A isoform a precursor	308	Helical; Name=6; (Potential).				activation of adenylate cyclase activity|artery smooth muscle contraction|cell proliferation|glucose transport|respiratory gaseous exchange	integral to plasma membrane	endothelin-A receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)|breast(1)	2	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.154)	Bosentan(DB00559)	GGCAAAAACAGTTTTCTGCTT	0.363000													41	55					0	0	0.014410	0	0
CDH10	1008	broad.mit.edu	37	5	24535308	24535308	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr5:24535308C>T	uc003jgr.1	-	5	1059	c.727G>A	c.(727-729)GGC>AGC	p.G243S	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	243	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		ATCTGGCCGCCCATGTCTTTG	0.473000										HNSCC(23;0.051)			24	59					0	0	0.004656	0	0
GHR	2690	broad.mit.edu	37	5	42711475	42711475	+	Splice_Site	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr5:42711475G>A	uc003jmt.2	+	7	827	c.784_splice	c.e7+1	p.D262_splice	GHR_uc011cpq.1_Splice_Site_p.D75_splice	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor						2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TGTGAAGAAGGTAAAAGAAAT	0.378000													25	61					0	0	0.021523	0	0
RGNEF	64283	broad.mit.edu	37	5	73168939	73168939	+	Silent	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr5:73168939C>T	uc011csq.1	+	21	2693	c.2682C>T	c.(2680-2682)TTC>TTT	p.F894F	RGNEF_uc003kcx.2_Silent_p.F894F|RGNEF_uc010izf.2_Silent_p.F894F|RGNEF_uc011csr.1_Silent_p.F581F	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	894	DH.				cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)		ATAAAATTTTCCCCTGTTTAG	0.468000													10	16					0	0	0.013537	0	0
VCAN	1462	broad.mit.edu	37	5	82817123	82817123	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr5:82817123C>T	uc003kii.3	+	7	3354	c.2998C>T	c.(2998-3000)CCC>TCC	p.P1000S	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Missense_Mutation_p.P1000S|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1000	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TCTAGGTGAACCCTCTCAAGA	0.428000													16	48					0	0	0.007413	0	0
SNCAIP	9627	broad.mit.edu	37	5	121780306	121780306	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr5:121780306G>A	uc003ksw.1	+	8	1677	c.1471G>A	c.(1471-1473)GAA>AAA	p.E491K	SNCAIP_uc011cwl.1_Missense_Mutation_p.E49K|SNCAIP_uc003ksx.1_Missense_Mutation_p.E538K|SNCAIP_uc003ksy.1_Missense_Mutation_p.E125K|SNCAIP_uc003ksz.1_Missense_Mutation_p.E125K|SNCAIP_uc010jcu.2_Missense_Mutation_p.E87K|SNCAIP_uc011cwm.1_Missense_Mutation_p.E125K|SNCAIP_uc003kta.1_Missense_Mutation_p.E123K|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Missense_Mutation_p.E185K|SNCAIP_uc010jcx.1_Missense_Mutation_p.E431K|uc003ktb.1_Intron|SNCAIP_uc003ktc.1_Missense_Mutation_p.E7K	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	491					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		CCACGCTGGGGAAAAGCCCTC	0.537000													52	53					0	0	0.014410	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215804	140215804	+	Silent	SNP	A	G	G			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr5:140215804A>G	uc003lhq.2	+	1	1836	c.1836A>G	c.(1834-1836)CAA>CAG	p.Q612Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.Q612Q	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	612	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGAGTTGCAACCGGTGGCGG	0.647000													28	99					0	0	0.012213	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554138	140554138	+	Silent	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr5:140554138G>A	uc003lit.2	+	1	1896	c.1722G>A	c.(1720-1722)GAG>GAA	p.E574E		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	574	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTGCACCGAGCCGTTGCCCC	0.701000													74	44					0	0	0.014410	0	0
WWC1	23286	broad.mit.edu	37	5	167850881	167850881	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr5:167850881C>T	uc003lzu.2	+	11	1711	c.1618C>T	c.(1618-1620)CTC>TTC	p.L540F	WWC1_uc003lzv.2_Missense_Mutation_p.L540F|WWC1_uc011den.1_Missense_Mutation_p.L540F|WWC1_uc003lzw.2_Missense_Mutation_p.L339F	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	540					cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		ACGTTCCTCTCTCTCCTCCCC	0.632000													27	68					0	0	0.015359	0	0
LMAN2	10960	broad.mit.edu	37	5	176764711	176764711	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr5:176764711G>A	uc003mge.2	-	4	746	c.509C>T	c.(508-510)ACT>ATT	p.T170I	LMAN2_uc003mgd.2_Missense_Mutation_p.T170I	NM_006816	NP_006807	Q12907	LMAN2_HUMAN	lectin, mannose-binding 2 precursor	170	Lumenal (Potential).|L-type lectin-like.				protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	metal ion binding|sugar binding				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCTACCTCAGTGGTCTCATC	0.547000													7	17					0	0	0.003080	0	0
PKHD1	5314	broad.mit.edu	37	6	51512867	51512867	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr6:51512867G>A	uc003pah.1	-	63	11636	c.11360C>T	c.(11359-11361)TCA>TTA	p.S3787L		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3787	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CAGGGAAGCTGAAATTGTCCA	0.423000													21	65					0	0	0.005443	0	0
PAQR8	85315	broad.mit.edu	37	6	52268794	52268794	+	Missense_Mutation	SNP	C	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr6:52268794C>A	uc003pao.3	+	2	957	c.783C>A	c.(781-783)TTC>TTA	p.F261L		NM_133367	NP_588608	Q8TEZ7	MPRB_HUMAN	progestin and adipoQ receptor family member	261	Helical; Name=5; (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding				0	Lung NSC(77;0.0875)					GCGCTTATTTCTTCTCCTGCC	0.572000													13	61					1.3612e-06	1.46162e-06	0.003163	1	0
GFRAL	389400	broad.mit.edu	37	6	55216368	55216368	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr6:55216368G>A	uc003pcm.1	+	5	774	c.688G>A	c.(688-690)GAT>AAT	p.D230N		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	230	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CTGCCAAAATGATGAATTATG	0.423000													10	28					0	0	0.013537	0	0
CALCR	799	broad.mit.edu	37	7	93108821	93108821	+	Splice_Site	SNP	T	C	C			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr7:93108821T>C	uc003umv.1	-	4	367	c.106_splice	c.e4-1	p.H36_splice	CALCR_uc003ums.1_Splice_Site|CALCR_uc003umt.1_Splice_Site|CALCR_uc003umu.1_Splice_Site_p.H18_splice|CALCR_uc003umw.2_Splice_Site_p.H18_splice	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor						activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	GGTTGGGTGCTGTATTAAAAA	0.363000													54	67					0	0	0.014410	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518355	113518355	+	Missense_Mutation	SNP	G	T	T	rs35449651	byFrequency	TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr7:113518355G>T	uc010ljy.1	-	4	2823	c.2792C>A	c.(2791-2793)GCA>GAA	p.A931E		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	931					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						TACAGCAATTGCCTGCTCATT	0.378000													52	75					1.53582e-20	1.70503e-20	0.014410	1	0
PTPRZ1	5803	broad.mit.edu	37	7	121653532	121653532	+	Missense_Mutation	SNP	T	A	A	rs144360433	byFrequency	TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr7:121653532T>A	uc003vjy.2	+	12	4827	c.4432T>A	c.(4432-4434)TCT>ACT	p.S1478T	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	1478	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						ATACTCACTATCTGAGAATTC	0.393000													56	61					0	0	0.014410	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				34	72					0	0	0.006999	0	0
MGAM	8972	broad.mit.edu	37	7	141732710	141732710	+	Splice_Site	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr7:141732710G>A	uc003vwy.2	+	14	1723	c.1669_splice	c.e14+1	p.R557_splice		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase						polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TTCACTCCCAGTAAGTCTTGG	0.373000													14	20					0	0	0.006122	0	0
MYOM2	9172	broad.mit.edu	37	8	2017587	2017587	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr8:2017587C>T	uc003wpx.3	+	8	902	c.764C>T	c.(763-765)CCA>CTA	p.P255L	MYOM2_uc011kwi.1_Intron	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	255					muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		GACGAGGAACCATTCCGTTCG	0.507000													121	42					0	0	0.014410	0	0
RP1L1	94137	broad.mit.edu	37	8	10469525	10469525	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr8:10469525C>T	uc003wtc.2	-	4	2312	c.2083G>A	c.(2083-2085)GCC>ACC	p.A695T		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	695					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TCCTGGCAGGCCCTTCGCCGC	0.617000													34	16					0	0	0.019004	0	0
HR	55806	broad.mit.edu	37	8	21982903	21982903	+	Missense_Mutation	SNP	G	C	C			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr8:21982903G>C	uc003xas.2	-	5	2336	c.1671C>G	c.(1669-1671)CAC>CAG	p.H557Q	HR_uc003xat.2_Missense_Mutation_p.H557Q	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	557							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CACTGAGCAGGTGCTTGGCGA	0.687000													12	6					0	0	0.003163	0	0
FAM135B	51059	broad.mit.edu	37	8	139163542	139163542	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr8:139163542G>A	uc003yuy.2	-	13	3347	c.3176C>T	c.(3175-3177)TCC>TTC	p.S1059F	FAM135B_uc003yux.2_Missense_Mutation_p.S960F|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.S621F|FAM135B_uc003yvb.2_Missense_Mutation_p.S621F	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1059										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GGTCTGTTTGGAAGAGAATCC	0.522000										HNSCC(54;0.14)			28	23					0	0	0.009535	0	0
LY6H	4062	broad.mit.edu	37	8	144239833	144239833	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr8:144239833G>A	uc011lka.1	-	4	423	c.257C>T	c.(256-258)TCA>TTA	p.S86L	LY6H_uc011lkb.1_Missense_Mutation_p.S107L|LY6H_uc003yxt.2_Missense_Mutation_p.S124L|LY6H_uc011lkc.1_Missense_Mutation_p.S107L	NM_002347	NP_002338	O94772	LY6H_HUMAN	lymphocyte antigen 6 complex, locus H isoform a	86	UPAR/Ly6.				nervous system development|organ morphogenesis	anchored to membrane|plasma membrane					0	all_cancers(97;6.49e-11)|all_epithelial(106;2.77e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					CAGATAGTCTGAGAAAAAGTG	0.547000													5	107					0	0	0.001168	0	0
RECK	8434	broad.mit.edu	37	9	36118962	36118962	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr9:36118962C>T	uc003zyv.2	+	18	2548	c.2462C>T	c.(2461-2463)CCG>CTG	p.P821L	RECK_uc003zyw.2_Missense_Mutation_p.P693L|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	821						anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			ATCATCCCACCGGGTAGGCTG	0.557000													27	55					0	0	0.008361	0	0
SH2D3C	10044	broad.mit.edu	37	9	130513556	130513556	+	Silent	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr9:130513556C>T	uc004bsc.2	-	4	721	c.579G>A	c.(577-579)CTG>CTA	p.L193L	SH2D3C_uc010mxo.2_Silent_p.L33L|SH2D3C_uc004bry.2_Silent_p.L35L|SH2D3C_uc004brz.3_5'UTR|SH2D3C_uc011mak.1_5'UTR|SH2D3C_uc004bsa.2_Silent_p.L36L|SH2D3C_uc004bsb.2_Silent_p.L125L	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	193					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						GCGATGAGTCCAGGATGTACT	0.517000													67	26					0	0	0.014410	0	0
TTF1	7270	broad.mit.edu	37	9	135277170	135277170	+	Missense_Mutation	SNP	C	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr9:135277170C>A	uc004cbl.2	-	2	1091	c.1039G>T	c.(1039-1041)GTG>TTG	p.V347L	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Intron	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	347					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		GGCATGGCCACTGCCTCAAAT	0.483000													3	107					0.004672	0.00489626	0.004672	1	0
KIAA2022	340533	broad.mit.edu	37	X	73963375	73963375	+	Silent	SNP	G	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chrX:73963375G>T	uc004eby.2	-	3	1634	c.1017C>A	c.(1015-1017)CCC>CCA	p.P339P		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	339					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TAAAGACGCTGGGAAAAAAGT	0.458000													39	22					3.61848e-18	3.98337e-18	0.007835	1	0
ODZ1	10178	broad.mit.edu	37	X	124030042	124030042	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chrX:124030042G>A	uc004euj.2	-	2	330	c.266C>T	c.(265-267)ACA>ATA	p.T89I	ODZ1_uc011muj.1_Missense_Mutation_p.T89I|ODZ1_uc010nqy.2_Missense_Mutation_p.T89I	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	89	Teneurin N-terminal.|Cytoplasmic (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						GTGCATGTCTGTTTGGTAGCC	0.473000													80	51					0	0	0.014410	0	0
OR13H1	347468	broad.mit.edu	37	X	130678233	130678233	+	Silent	SNP	C	T	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chrX:130678233C>T	uc011muw.1	+	1	186	c.186C>T	c.(184-186)TTC>TTT	p.F62F	IGSF1_uc004ewf.2_Intron	NM_001004486	NP_001004486	Q8NG92	O13H1_HUMAN	olfactory receptor, family 13, subfamily H,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Acute lymphoblastic leukemia(192;0.000636)					TCTACTTCTTCCTTAGTAACC	0.433000													52	32					0	0	0.014410	0	0
CEP290	80184	broad.mit.edu	37	12	88512305	88512305	+	Frame_Shift_Del	DEL	T	-	-	rs77980773		TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr12:88512305delT	uc001tar.2	-	17	2010	c.1666delA	c.(1666-1668)ATTfs	p.I556fs	CEP290_uc001tat.2_Frame_Shift_Del_p.I318fs|CEP290_uc009zsl.1_RNA	NM_025114	NP_079390	O15078	CE290_HUMAN	centrosomal protein 290kDa	556	Potential.				cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7						ATTTGACGAATTTTTTTTTTC	0.308													2	4	---	---	---	---					
ZNF382	84911	broad.mit.edu	37	19	37117823	37117823	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:37117823delC	uc002oek.2	+	5	1137	c.1024delC	c.(1024-1026)CATfs	p.H342fs	ZNF382_uc010efa.2_Frame_Shift_Del_p.H293fs|ZNF382_uc010efb.2_Frame_Shift_Del_p.H341fs|ZNF382_uc002oel.2_Frame_Shift_Del_p.H341fs	NM_032825	NP_116214	Q96SR6	ZN382_HUMAN	zinc finger protein 382	342	Required for transcriptional repression activity; probably mediates sequence- specific DNA-binding (By similarity).|C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			CCTCACCCTTCATGAGAAAAC	0.448													95	46	---	---	---	---					
ASXL2	55252	broad.mit.edu	37	2	26022304	26022306	+	In_Frame_Del	DEL	CTG	-	-			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr2:26022304_26022306delCTG	uc002rgs.2	-	4	572_574	c.351_353delCAG	c.(349-354)AGCAGT>AGT	p.117_118SS>S		NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	117_118	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCACCATCACTGCTGCTGCTGC	0.463													7	221	---	---	---	---					
CTCFL	140690	broad.mit.edu	37	20	56099187	56099187	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr20:56099187delT	uc010gix.1	-	1	737	c.75delA	c.(73-75)AAAfs	p.K25fs	CTCFL_uc010giw.1_Frame_Shift_Del_p.K25fs|CTCFL_uc002xym.2_Frame_Shift_Del_p.K25fs|CTCFL_uc010giz.1_Intron|CTCFL_uc010giy.1_Intron|CTCFL_uc010gja.1_Frame_Shift_Del_p.K25fs|CTCFL_uc010gjb.1_Frame_Shift_Del_p.K25fs|CTCFL_uc010gjc.1_Frame_Shift_Del_p.K25fs|CTCFL_uc010gjd.1_Frame_Shift_Del_p.K25fs|CTCFL_uc010gje.2_Frame_Shift_Del_p.K25fs|CTCFL_uc010gjf.2_Intron|CTCFL_uc010gjg.2_Intron|CTCFL_uc010gjh.1_Frame_Shift_Del_p.K25fs|CTCFL_uc010gji.1_Intron|CTCFL_uc010gjj.1_Frame_Shift_Del_p.K25fs|CTCFL_uc010gjk.1_Frame_Shift_Del_p.K25fs|CTCFL_uc010gjl.1_Frame_Shift_Del_p.K25fs	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	25					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			CCTTCAGGCCTTTTTCCGGCA	0.502													7	722	---	---	---	---					
