Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SSU72	29101	broad.mit.edu	37	1	1480368	1480369	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr1:1480368_1480369CC>AA	uc001agd.2	-	3	563_564	c.238_239GG>TT	c.(238-240)GGG>TTG	p.G80L	SSU72_uc009vkg.1_Missense_Mutation_p.G80L	NM_014188	NP_054907	Q9NP77	SSU72_HUMAN	Ssu72 RNA polymerase II CTD phosphatase homolog	80					mRNA processing	cytoplasm|nucleus	phosphoprotein phosphatase activity				0	all_cancers(77;0.00125)|all_epithelial(69;0.000703)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.03e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;5.04e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.72e-23)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;0.000188)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|BRCA - Breast invasive adenocarcinoma(365;0.00837)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		ATGTAAAATCCCATTCTGTGTA	0.480000													7	99					0	0	6.4e-05	0	0
HSPG2	3339	broad.mit.edu	37	1	22178171	22178171	+	Silent	SNP	G	A	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr1:22178171G>A	uc001bfj.2	-	55	7066	c.7026C>T	c.(7024-7026)CCC>CCT	p.P2342P	HSPG2_uc009vqd.2_Silent_p.P2343P	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2342	Ig-like C2-type 9.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CGATGCGGATGGGCTGGGTGC	0.642000													8	34					0	0	3.86212e-05	0	0
DOCK7	85440	broad.mit.edu	37	1	63048872	63048872	+	Silent	SNP	G	C	C			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr1:63048872G>C	uc001daq.2	-	16	1888	c.1854C>G	c.(1852-1854)GCC>GCG	p.A618A	DOCK7_uc001dan.2_Silent_p.A510A|DOCK7_uc001dao.2_Silent_p.A510A|DOCK7_uc001dap.2_Silent_p.A618A	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	618	DHR-1.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						GATATACTACGGCTGTATAGG	0.348000													5	143					0	0	8.12818e-05	0	0
PTBP2	58155	broad.mit.edu	37	1	97278427	97278427	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr1:97278427C>T	uc001drq.2	+	12	1577	c.1331C>T	c.(1330-1332)TCC>TTC	p.S444F	PTBP2_uc001drn.2_Missense_Mutation_p.S449F|PTBP2_uc001dro.2_Missense_Mutation_p.S444F|PTBP2_uc010otz.1_Missense_Mutation_p.S460F|PTBP2_uc001drp.2_RNA|PTBP2_uc009wdw.2_Missense_Mutation_p.S392F|PTBP2_uc001drr.2_Missense_Mutation_p.S449F|PTBP2_uc010oua.1_Missense_Mutation_p.S452F|PTBP2_uc001dru.2_RNA|PTBP2_uc001drs.1_Missense_Mutation_p.S63F|PTBP2_uc001drt.2_Missense_Mutation_p.S63F	NM_021190	NP_067013	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	444							nucleotide binding				0		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		AAACCTGGATCCAAAAATTTT	0.373000													9	26					0	0	2.17888e-05	0	0
CLCC1	23155	broad.mit.edu	37	1	109479864	109479865	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr1:109479864_109479865GG>TT	uc001dwe.1	-	10	1309_1310	c.1217_1218CC>AA	c.(1216-1218)CCC>CAA	p.P406Q	AKNAD1_uc010ovb.1_Intron|CLCC1_uc001dwf.1_Missense_Mutation_p.P406Q|CLCC1_uc001dwg.1_Missense_Mutation_p.P356Q|CLCC1_uc009wes.1_Missense_Mutation_p.P285Q|CLCC1_uc009wet.1_Missense_Mutation_p.P221Q	NM_001048210	NP_001041675	Q96S66	CLCC1_HUMAN	Mid-1-related chloride channel 1 isoform 1	406						endoplasmic reticulum|Golgi apparatus|integral to membrane|nucleus				liver(1)	1		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.231)		CTTGCTCAGTGGGGCCCATTTG	0.500000													8	199					0	0	6.4e-05	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144917924	144917925	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr1:144917924_144917925CC>AA	uc001elw.3	-	11	1652_1653	c.1361_1362GG>TT	c.(1360-1362)CGG>CTT	p.R454L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.R520L|PDE4DIP_uc001emc.1_Missense_Mutation_p.R454L|PDE4DIP_uc001emd.1_Missense_Mutation_p.R454L|PDE4DIP_uc001emb.1_Missense_Mutation_p.R617L|PDE4DIP_uc001eme.1_5'UTR|PDE4DIP_uc001emf.1_Missense_Mutation_p.R241L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	454	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GTAGGAGCTCCCGAAATTCCTG	0.262000			T	PDGFRB	MPD								9	301					0	0	6.4e-05	0	0
NBPF10	100132406	broad.mit.edu	37	1	145311151	145311152	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr1:145311151_145311152CC>AA	uc001end.3	+	13	1885_1886	c.1850_1851CC>AA	c.(1849-1851)CCC>CAA	p.P617Q	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Missense_Mutation_p.Q494K|NBPF9_uc010oyg.1_Missense_Mutation_p.Q528K|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Missense_Mutation_p.P156Q|NBPF10_uc010oyk.1_5'Flank|NBPF10_uc010oyl.1_5'Flank|NBPF10_uc001emq.1_Missense_Mutation_p.Q292K|NBPF10_uc010oyj.1_5'Flank	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	542											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GCAACAGGTCCCAGGTGAGTCT	0.426000													11	354					0	0	6.4e-05	0	0
NBPF14	25832	broad.mit.edu	37	1	148012531	148012531	+	Silent	SNP	C	T	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr1:148012531C>T	uc001eqq.2	-	12	1445	c.1428G>A	c.(1426-1428)AAG>AAA	p.K476K	LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqf.2_Intron|LOC200030_uc001eqg.2_Intron|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Intron|NBPF14_uc001eqx.2_Silent_p.K387K|NBPF14_uc010pae.1_Silent_p.K143K|NBPF14_uc010paf.1_Silent_p.K631K|NBPF14_uc010pad.1_5'Flank|NBPF14_uc001eqs.1_Intron	NM_015383	NP_056198	Q5TI25	NBPFE_HUMAN	hypothetical protein LOC25832	476	NBPF 5.					cytoplasm				ovary(1)	1	all_hematologic(923;0.032)					AGCCAACATGCTTTTCCTCCA	0.443000													4	8					0	0	2.56e-06	0	0
CACNA1S	779	broad.mit.edu	37	1	201042689	201042690	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr1:201042689_201042690GG>TT	uc001gvv.2	-	15	2371_2372	c.2144_2145CC>AA	c.(2143-2145)CCC>CAA	p.P715Q		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	715	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TGGCAGTGGTGGGGATGCCCTC	0.550000													8	240					0	0	6.4e-05	0	0
RRP15	51018	broad.mit.edu	37	1	218458675	218458675	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr1:218458675C>G	uc001hlj.2	+	1	47	c.17C>G	c.(16-18)CCG>CGG	p.P6R		NM_016052	NP_057136	Q9Y3B9	RRP15_HUMAN	ribosomal RNA processing 15 homolog	6						mitochondrion|nucleolus	protein binding				0				all cancers(67;0.0315)|OV - Ovarian serous cystadenocarcinoma(81;0.0411)|GBM - Glioblastoma multiforme(131;0.06)|Epithelial(68;0.248)		GCCGCCGCTCCGGACTCACGT	0.547000													21	19					0	0	3.10358e-05	0	0
TAF1A	9015	broad.mit.edu	37	1	222743899	222743900	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr1:222743899_222743900GG>TT	uc009xdz.1	-	6	901_902	c.712_713CC>AA	c.(712-714)CCT>AAT	p.P238N	TAF1A_uc001hni.1_Missense_Mutation_p.P124N|TAF1A_uc001hnj.2_Missense_Mutation_p.P238N|TAF1A_uc001hnk.2_Missense_Mutation_p.P124N|TAF1A_uc010pur.1_Missense_Mutation_p.P238N	NM_139352	NP_647603	Q15573	TAF1A_HUMAN	TBP-associated factor 1A isoform 2	238					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	RNA polymerase I transcription factor complex	DNA binding				0				GBM - Glioblastoma multiforme(131;0.0186)		CTTCACAAAAGGGTCCCAAACT	0.342000													11	338					0	0	6.4e-05	0	0
CHRM3	1131	broad.mit.edu	37	1	240071307	240071307	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr1:240071307G>C	uc001hyp.2	+	5	1335	c.556G>C	c.(556-558)GGT>CGT	p.G186R		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	186	Helical; Name=4; (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	AAAGAGAGCCGGTGTGATGAT	0.502000													5	134					0	0	5.18039e-06	0	0
RGS7	6000	broad.mit.edu	37	1	241099908	241099908	+	Silent	SNP	G	T	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr1:241099908G>T	uc001hyv.2	-	5	655	c.325C>A	c.(325-327)CGG>AGG	p.R109R	RGS7_uc010pyh.1_Silent_p.R83R|RGS7_uc010pyj.1_Silent_p.R25R|RGS7_uc001hyu.2_Silent_p.R109R|RGS7_uc009xgn.1_Intron|RGS7_uc001hyw.2_Silent_p.R109R	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	109	DEP.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			ACTTGAAACCGGTAAAAGGTG	0.398000													6	144					8.12818e-05	0.00548321	8.12818e-05	1	0
UPF2	26019	broad.mit.edu	37	10	11994238	11994238	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr10:11994238C>A	uc001ila.2	-	14	3335	c.2861G>T	c.(2860-2862)TGG>TTG	p.W954L	UPF2_uc001ilb.2_Missense_Mutation_p.W954L|UPF2_uc001ilc.2_Missense_Mutation_p.W954L|UPF2_uc009xiz.1_Missense_Mutation_p.W954L	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	954	MIF4G 3.|Sufficient for interaction with EIF4A1 and EIF1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				TTTCTTCCACCAAACATAACG	0.294000													9	216					1.58986e-06	0.000109485	3.86212e-05	1	0
ZNF248	57209	broad.mit.edu	37	10	38120724	38120724	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr10:38120724T>C	uc001izd.1	-	6	2058	c.1559A>G	c.(1558-1560)TAT>TGT	p.Y520C	ZNF248_uc009xmc.2_Intron|ZNF248_uc001izb.2_Intron|ZNF248_uc001izc.2_Intron|ZNF248_uc010qeu.1_Missense_Mutation_p.Y520C	NM_021045	NP_066383	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	520	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATTACACTTATATGGTTTCTC	0.408000													19	18					0	0	9.7654e-05	0	0
HERC4	26091	broad.mit.edu	37	10	69785421	69785421	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr10:69785421A>G	uc001jng.3	-	8	1101	c.790T>C	c.(790-792)TTT>CTT	p.F264L	HERC4_uc001jnf.3_RNA|HERC4_uc001jnh.3_Missense_Mutation_p.F264L|HERC4_uc009xpr.2_Missense_Mutation_p.F264L|HERC4_uc001jni.3_Missense_Mutation_p.F8L|HERC4_uc001jnj.2_Missense_Mutation_p.F264L	NM_022079	NP_071362	Q5GLZ8	HERC4_HUMAN	hect domain and RLD 4 isoform a	264	RCC1 6.				cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			ovary(1)|breast(1)|skin(1)	3						CCAAAAGTAAACACTCCACCT	0.358000													26	23					0	0	2.90539e-05	0	0
MUC6	4588	broad.mit.edu	37	11	1017099	1017100	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr11:1017099_1017100CC>AA	uc001lsw.2	-	31	5752_5753	c.5701_5702GG>TT	c.(5701-5703)GGG>TTG	p.G1901L		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	1901	Thr-rich.|2.|Approximate repeats.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TTGGCTGGTCCCACTGGTGGTC	0.554000													15	465					0	0	6.4e-05	0	0
NOX4	50507	broad.mit.edu	37	11	89073294	89073295	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr11:89073294_89073295CC>AA	uc001pct.2	-	15	1621_1622	c.1382_1383GG>TT	c.(1381-1383)TGG>TTT	p.W461F	NOX4_uc009yvr.2_Missense_Mutation_p.W436F|NOX4_uc001pcu.2_Missense_Mutation_p.W387F|NOX4_uc001pcw.2_Missense_Mutation_p.W154F|NOX4_uc001pcx.2_Missense_Mutation_p.W114F|NOX4_uc001pcv.2_Missense_Mutation_p.W421F|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_Missense_Mutation_p.W295F|NOX4_uc009yvp.2_Missense_Mutation_p.W225F|NOX4_uc010rtv.1_Missense_Mutation_p.W397F|NOX4_uc009yvq.2_Missense_Mutation_p.W437F	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	461	Cytoplasmic (Potential).|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				CTCTGCATACCCAAATAAAGTA	0.342000													8	146					0	0	6.4e-05	0	0
FAT3	120114	broad.mit.edu	37	11	92086445	92086446	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr11:92086445_92086446CC>AA	uc001pdj.3	+	1	1184_1185	c.1167_1168CC>AA	c.(1165-1170)TCCCCT>TCAACT	p.P390T		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	390	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTGAATTTTCCCCTCCTGGTGT	0.401000										TCGA Ovarian(4;0.039)			13	386					0	0	6.4e-05	0	0
FAT3	120114	broad.mit.edu	37	11	92570935	92570936	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr11:92570935_92570936CG>AT	uc001pdj.3	+	16	10348_10349	c.10331_10332CG>AT	c.(10330-10332)CCG>CAT	p.P3444H	FAT3_uc001pdi.3_5'Flank	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3444	Extracellular (Potential).|Cadherin 31.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GACAACAGCCCGGTGTTTACAC	0.470000										TCGA Ovarian(4;0.039)			9	315					0	0	6.4e-05	0	0
SLC36A4	120103	broad.mit.edu	37	11	92895975	92895976	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr11:92895975_92895976CC>AA	uc001pdn.2	-	9	1030_1031	c.933_934GG>TT	c.(931-936)ATGGGG>ATTTGG	p.311_312MG>IW	SLC36A4_uc001pdm.2_Missense_Mutation_p.176_177MG>IW	NM_152313	NP_689526	Q6YBV0	S36A4_HUMAN	solute carrier family 36 (proton/amino acid	311_312	Helical; (Potential).				L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GTAACAATCCCCATGCCAATAT	0.347000													12	459					0	0	6.4e-05	0	0
LAYN	143903	broad.mit.edu	37	11	111428347	111428348	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr11:111428347_111428348GG>TT	uc001plr.1	+	7	1100_1101	c.764_765GG>TT	c.(763-765)TGG>TTT	p.W255F	LAYN_uc001plp.1_Missense_Mutation_p.W247F|LAYN_uc001plq.1_Missense_Mutation_p.W255F|LAYN_uc001pls.1_Missense_Mutation_p.W247F|LAYN_uc010rwg.1_Missense_Mutation_p.W102F|LAYN_uc010rwh.1_Missense_Mutation_p.W103F	NM_178834	NP_849156	Q6UX15	LAYN_HUMAN	layilin	255	Helical; (Potential).					cell surface|integral to membrane|ruffle	hyaluronic acid binding|sugar binding				0		all_cancers(61;9.06e-10)|all_epithelial(67;1.34e-05)|Melanoma(852;1.74e-05)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.086)		Epithelial(105;1.5e-06)|BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|all cancers(92;2.45e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0476)		GTTGTATGTTGGGTTTGGATCT	0.421000													10	410					0	0	6.4e-05	0	0
TAS2R46	259292	broad.mit.edu	37	12	11214123	11214123	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr12:11214123G>C	uc001qzp.1	-	1	771	c.771C>G	c.(769-771)AAC>AAG	p.N257K	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176887	NP_795368	P59540	T2R46_HUMAN	taste receptor, type 2, member 46	257	Extracellular (Potential).				sensory perception of taste	cilium membrane|integral to membrane	G-protein coupled receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)		AGACAGGTTTGTTTTCCAGAC	0.408000													33	183					0	0	8.91981e-05	0	0
TMBIM6	7009	broad.mit.edu	37	12	50152510	50152510	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr12:50152510G>C	uc001rux.2	+	7	610	c.478G>C	c.(478-480)GGG>CGG	p.G160R	TMBIM6_uc010sml.1_Intron|TMBIM6_uc001ruy.2_Missense_Mutation_p.G218R|TMBIM6_uc001ruz.2_Missense_Mutation_p.G160R	NM_003217	NP_003208	P55061	BI1_HUMAN	testis enhanced gene transcript (BAX inhibitor	160	Helical; (Potential).				apoptosis|negative regulation of apoptosis	endoplasmic reticulum|insoluble fraction|integral to plasma membrane|nucleus					0						GTCTTCCCTGGGGAATGTTTT	0.403000													3	61					0	0	6.4e-05	0	0
NAB2	4665	broad.mit.edu	37	12	57485446	57485446	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr12:57485446T>C	uc001smz.2	+	2	1000	c.622T>C	c.(622-624)TTC>CTC	p.F208L		NM_005967	NP_005958	Q15742	NAB2_HUMAN	NGFI-A binding protein 2	208					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			upper_aerodigestive_tract(1)|ovary(1)	2						CTCGCCCCCCTTCTCCCCCCC	0.716000													5	7					0	0	3.59834e-05	0	0
LEMD3	23592	broad.mit.edu	37	12	65564456	65564456	+	Silent	SNP	C	T	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr12:65564456C>T	uc001ssl.1	+	1	1086	c.1080C>T	c.(1078-1080)AAC>AAT	p.N360N	LEMD3_uc009zqo.1_Silent_p.N360N	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	360					negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		ACCGTGTTAACGCTAAGAAAC	0.552000													8	30					0	0	1.12685e-05	0	0
KCNC2	3747	broad.mit.edu	37	12	75444669	75444669	+	Silent	SNP	T	A	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr12:75444669T>A	uc001sxg.1	-	3	1660	c.1116A>T	c.(1114-1116)GGA>GGT	p.G372G	KCNC2_uc009zry.2_Silent_p.G372G|KCNC2_uc001sxe.2_Silent_p.G372G|KCNC2_uc001sxf.2_Silent_p.G372G|KCNC2_uc010stw.1_Silent_p.G372G	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	372	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						GAAGAGTATGTCCAAGCACCC	0.443000													5	22					0	0	1.23904e-05	0	0
DTX1	1840	broad.mit.edu	37	12	113515257	113515257	+	Silent	SNP	C	T	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr12:113515257C>T	uc001tuk.1	+	2	624	c.288C>T	c.(286-288)TTC>TTT	p.F96F		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	deltex homolog 1	96	WWE 2.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4						GGCGCAACTTCTACGACCCGT	0.672000													6	23					0	0	3.59834e-05	0	0
P2RX4	5025	broad.mit.edu	37	12	121666527	121666528	+	Splice_Site	DNP	GG	TT	TT			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr12:121666527_121666528GG>TT	uc001tzr.2	+	7	910	c.606_splice	c.e7-1	p.K202_splice	P2RX4_uc010szr.1_Splice_Site|P2RX4_uc010szs.1_Splice_Site|P2RX4_uc009zxc.2_Splice_Site_p.K175_splice|P2RX4_uc001tzs.2_Splice_Site_p.K218_splice|P2RX4_uc009zxb.2_Splice_Site|P2RX4_uc010szt.1_Splice_Site_p.K101_splice	NM_002560	NP_002551	Q99571	P2RX4_HUMAN	purinergic receptor P2X4						endothelial cell activation|negative regulation of cardiac muscle hypertrophy|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|regulation of apoptosis|regulation of blood pressure|regulation of sodium ion transport|relaxation of cardiac muscle|response to ATP|response to fluid shear stress|sensory perception of pain|tissue homeostasis	cell junction|perinuclear region of cytoplasm	cadherin binding|copper ion binding|extracellular ATP-gated cation channel activity|protein homodimerization activity|purinergic nucleotide receptor activity|receptor binding|zinc ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CTCGACTTTAGGAGGAATATCC	0.465000													9	208					0	0	6.4e-05	0	0
RSRC2	65117	broad.mit.edu	37	12	123001841	123001841	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr12:123001841G>A	uc001ucr.2	-	5	681	c.535C>T	c.(535-537)CGT>TGT	p.R179C	RSRC2_uc001uco.2_5'UTR|RSRC2_uc001ucp.2_Missense_Mutation_p.R120C|RSRC2_uc001ucq.2_5'UTR|RSRC2_uc001ucs.2_5'UTR|RSRC2_uc001uct.2_Missense_Mutation_p.R131C|RSRC2_uc001ucu.2_Missense_Mutation_p.R179C	NM_023012	NP_075388	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2 isoform a	179	Ser-rich.									ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		GAGCGGGAACGAGACCTGATC	0.483000													39	27					0	0	0.000125731	0	0
SLITRK1	114798	broad.mit.edu	37	13	84453583	84453583	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr13:84453583T>C	uc001vlk.2	-	1	2946	c.2060A>G	c.(2059-2061)TAT>TGT	p.Y687C		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	687	Cytoplasmic (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GCCACAGTCATACACTCTGTG	0.587000													7	18					0	0	8.12818e-05	0	0
GLCE	26035	broad.mit.edu	37	15	69561456	69561456	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr15:69561456G>C	uc002ary.1	+	5	1955	c.1727G>C	c.(1726-1728)TGG>TCG	p.W576S		NM_015554	NP_056369	O94923	GLCE_HUMAN	D-glucuronyl C5-epimerase	576	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process|heparin biosynthetic process	Golgi membrane|integral to membrane	UDP-glucuronate 5'-epimerase activity			ovary(2)	2						CTGGCTCGCTGGGACTATCAT	0.483000													4	137					0	0	1.23904e-05	0	0
BLM	641	broad.mit.edu	37	15	91308573	91308574	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr15:91308573_91308574GG>TT	uc002bpr.2	+	9	2219_2220	c.2122_2123GG>TT	c.(2122-2124)GGG>TTG	p.G708L	BLM_uc010uqh.1_Missense_Mutation_p.G708L|BLM_uc010uqi.1_Missense_Mutation_p.G333L|BLM_uc010bnx.2_Missense_Mutation_p.G708L|BLM_uc002bps.1_Missense_Mutation_p.G270L	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	708	Helicase ATP-binding.				double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			TGTTTCTCCTGGGGTCACTGTT	0.401000			Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				10	350					0	0	6.4e-05	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53725986	53725986	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr16:53725986G>C	uc002ehp.2	-	4	585	c.521C>G	c.(520-522)CCC>CGC	p.P174R	RPGRIP1L_uc002eho.3_Missense_Mutation_p.P174R|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.P174R|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.P174R|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.P174R|RPGRIP1L_uc002ehq.1_Missense_Mutation_p.P174R	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	174					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				ACCTTTCCTGGGGCATTCCTG	0.353000													6	326					0	0	8.12818e-05	0	0
C17orf76	388341	broad.mit.edu	37	17	16347246	16347246	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr17:16347246G>A	uc010cph.1	-	4	867	c.691C>T	c.(691-693)CGC>TGC	p.R231C	C17orf76_uc002gqh.2_Missense_Mutation_p.P192L|NCRNA00188_uc010vwl.1_Intron|NCRNA00188_uc010vwm.1_Intron|NCRNA00188_uc010vwn.1_Intron|NCRNA00188_uc010cpe.2_Intron|NCRNA00188_uc010vwo.1_Intron|NCRNA00188_uc010vwp.1_Intron|C17orf76_uc002gqg.1_3'UTR	NM_001113567	NP_001107039	Q8NAA5	CQ076_HUMAN	hypothetical protein LOC388341 isoform 1	231	LRR 2.										0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0887)		GTGGTGAGGCGGGGCAGGGTG	0.632000													6	24					0	0	3.59834e-05	0	0
TBC1D3P2	440452	broad.mit.edu	37	17	60342234	60342234	+	RNA	SNP	C	T	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr17:60342234C>T	uc010woz.1	-	14		c.1895G>A				NR_027486				Homo sapiens cDNA FLJ60189 complete cds, highly similar to TBC1 domain family member 3.												0						GTCTGGTGTGCTCCATCTCTG	0.498000													4	26					0	0	1.23904e-05	0	0
C17orf80	55028	broad.mit.edu	37	17	71231869	71231869	+	Missense_Mutation	SNP	T	G	G	rs148616003		TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr17:71231869T>G	uc002jjm.3	+	3	442	c.248T>G	c.(247-249)GTG>GGG	p.V83G	C17orf80_uc010wqu.1_Missense_Mutation_p.V83G|C17orf80_uc010dfj.2_Missense_Mutation_p.V83G|C17orf80_uc002jjk.1_Missense_Mutation_p.V83G|C17orf80_uc002jjl.3_Missense_Mutation_p.V83G	NM_017941	NP_060411	Q9BSJ5	CQ080_HUMAN	lung cancer-related protein 8 isoform a	83	Extracellular (Potential).					integral to membrane				skin(1)	1			LUSC - Lung squamous cell carcinoma(166;0.197)			AAGTTGGTGGTGGACAAACCA	0.398000													11	32					0	0	6.40141e-05	0	0
INSR	3643	broad.mit.edu	37	19	7267679	7267680	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr19:7267679_7267680CG>AT	uc002mgd.1	-	2	437_438	c.328_329CG>AT	c.(328-330)CGG>ATG	p.R110M	INSR_uc002mge.1_Missense_Mutation_p.R110M|INSR_uc002mgf.2_Missense_Mutation_p.R110M	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	110					activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCGTGATCCCCGGATGACCGTG	0.530000													8	239					0	0	6.4e-05	0	0
SIGLEC11	114132	broad.mit.edu	37	19	50455562	50455562	+	Missense_Mutation	SNP	C	T	T	rs140702198	byFrequency	TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr19:50455562C>T	uc010ybh.1	-	9	1832	c.1741G>A	c.(1741-1743)GTC>ATC	p.V581I	SIGLEC11_uc010ybi.1_Missense_Mutation_p.V485I	NM_052884	NP_443116	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11 isoform 1	581	Helical; (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|central_nervous_system(2)|pancreas(1)	6		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		TACCTGAAGACGACAAGGCAG	0.622000													20	25					0	0	3.10358e-05	0	0
SIGLECP3	284367	broad.mit.edu	37	19	51671531	51671531	+	Missense_Mutation	SNP	C	T	T	rs139300887	by1000genomes	TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr19:51671531C>T	uc010ycv.1	+	3	680	c.670C>T	c.(670-672)CGG>TGG	p.R224W	SIGLECP3_uc010ycu.1_Missense_Mutation_p.R224W|SIGLECP3_uc002pvy.3_Missense_Mutation_p.R224W|SIGLECP3_uc002pvz.3_Missense_Mutation_p.R224W					SubName: Full=cDNA FLJ56974, moderately similar to Myeloid cell surface antigen CD33;												0						GATCATCCCACGGCCTCAGGA	0.627000													5	13					0	0	1.23904e-05	0	0
DYNC2LI1	51626	broad.mit.edu	37	2	44021765	44021765	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr2:44021765A>G	uc002rtk.2	+	6	586	c.490A>G	c.(490-492)ATG>GTG	p.M164V	DYNC2LI1_uc002rth.2_Missense_Mutation_p.M164V|DYNC2LI1_uc002rti.2_3'UTR|DYNC2LI1_uc002rtj.2_Missense_Mutation_p.M164V|DYNC2LI1_uc002rtl.2_Missense_Mutation_p.M164V|DYNC2LI1_uc010ynz.1_Missense_Mutation_p.M38V	NM_016008	NP_057092	Q8TCX1	DC2L1_HUMAN	dynein 2 light intermediate chain isoform 1	164						apical part of cell|axonemal dynein complex|cilium axoneme|cytoplasm|microtubule|motile primary cilium	motor activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CTGGAATAATATGCCGAAGGA	0.363000													106	302					0	0	0.000147903	0	0
LRPPRC	10128	broad.mit.edu	37	2	44126674	44126675	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr2:44126674_44126675GG>TT	uc002rtr.2	-	33	3697_3698	c.3639_3640CC>AA	c.(3637-3642)CCCCAA>CCAAAA	p.Q1214K		NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	1214	RNA-binding.				mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CCGAAGTATTGGGGTTCAATGA	0.327000													11	399					0	0	6.4e-05	0	0
FANCL	55120	broad.mit.edu	37	2	58431349	58431349	+	Silent	SNP	C	A	A	rs141400460	byFrequency	TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr2:58431349C>A	uc002rzw.3	-	6	454	c.387G>T	c.(385-387)GCG>GCT	p.A129A	FANCL_uc002rzx.3_Silent_p.A129A|FANCL_uc010fce.2_Silent_p.A129A|FANCL_uc010fcf.1_Silent_p.A70A	NM_018062	NP_060532	Q9NW38	FANCL_HUMAN	Fanconi anemia, complementation group L isoform	129					DNA repair	cytoplasm|nucleoplasm	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						AGCAGGTATCCGCATACACAA	0.423000								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				6	108					8.12818e-05	0.00548321	8.12818e-05	1	0
CKAP2L	150468	broad.mit.edu	37	2	113514717	113514717	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr2:113514717T>G	uc002tie.2	-	4	310	c.231A>C	c.(229-231)AAA>AAC	p.K77N	CKAP2L_uc002tif.2_5'UTR|CKAP2L_uc010yxp.1_5'UTR|CKAP2L_uc010yxq.1_5'UTR	NM_152515	NP_689728	Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	77						centrosome					0						TGGGCTGGAGTTTAATGCTGA	0.413000													27	99					0	0	0.000147802	0	0
TUBA3D	113457	broad.mit.edu	37	2	132238267	132238267	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr2:132238267C>T	uc002tsu.3	+	4	1108	c.1001C>T	c.(1000-1002)ACC>ATC	p.T334I		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	334					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		GCCATCGCCACCATCAAGACC	0.562000													10	38					0	0	3.86212e-05	0	0
TTN	7273	broad.mit.edu	37	2	179401227	179401227	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr2:179401227G>C	uc010zfg.1	-	306	92767	c.92543C>G	c.(92542-92544)CCT>CGT	p.P30848R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P24543R|TTN_uc010zfi.1_Missense_Mutation_p.P24476R|TTN_uc010zfj.1_Missense_Mutation_p.P24351R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31775							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCACTGGCAGGTGGCTTCCA	0.403000													3	80					0	0	2.56e-06	0	0
NBEAL1	65065	broad.mit.edu	37	2	203996775	203996776	+	Missense_Mutation	DNP	CG	AT	AT	rs139437459	by1000genomes	TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr2:203996775_203996776CG>AT	uc002uzt.3	+	25	3890_3891	c.3557_3558CG>AT	c.(3556-3558)TCG>TAT	p.S1186Y		NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	1186							binding			ovary(1)|skin(1)	2						GTTGGCTACTCGGGACTGGGAC	0.361000													7	307					0	0	6.4e-05	0	0
AQP12A	375318	broad.mit.edu	37	2	241631380	241631380	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr2:241631380T>A	uc002vzu.2	+	1	119	c.50T>A	c.(49-51)CTC>CAC	p.L17H	AQP12A_uc002vzv.2_Intron	NM_198998	NP_945349	Q8IXF9	AQ12A_HUMAN	aquaporin 12A	17	Helical; Name=1; (Potential).					integral to membrane	transporter activity				0		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		ACCTTCGCCCTCTGTGAGGCG	0.687000													6	33					0	0	8.12818e-05	0	0
FRG1B	284802	broad.mit.edu	37	20	29628251	29628251	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr20:29628251A>G	uc010ztl.1	+	3	195	c.163A>G	c.(163-165)AAT>GAT	p.N55D	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Missense_Mutation_p.N7D					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						GTTGGCCTCAAATAGCTGCTT	0.358000													6	86					0	0	1.12685e-05	0	0
TPTE	7179	broad.mit.edu	37	21	11012916	11012916	+	Splice_Site	SNP	C	A	A	rs4041777		TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr21:11012916C>A	uc002yis.1	-	9		c.1704_splice	c.e9+1					P56180	TPTE_HUMAN	Homo sapiens putative tyrosine phosphatase mRNA, complete cds.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCAAATTTTACCTAGCTTTTT	0.299000													29	44					1.77063e-15	1.23217e-13	0.000117367	1	0
TPTE	7179	broad.mit.edu	37	21	11012923	11012923	+	RNA	SNP	T	C	C			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr21:11012923T>C	uc002yis.1	-	9		c.1698A>G						P56180	TPTE_HUMAN	Homo sapiens putative tyrosine phosphatase mRNA, complete cds.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTACCTAGCTTTTTTACTTTT	0.289000													31	46					0	0	2.25844e-05	0	0
N6AMT1	29104	broad.mit.edu	37	21	30250581	30250581	+	Silent	SNP	G	C	C			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr21:30250581G>C	uc002ymo.1	-	5	497	c.471C>G	c.(469-471)CCC>CCG	p.P157P	N6AMT1_uc002ymp.1_Silent_p.P129P|N6AMT1_uc002ymq.1_RNA	NM_013240	NP_037372	Q9Y5N5	HEMK2_HUMAN	N-6 adenine-specific DNA methyltransferase 1	157					positive regulation of cell growth	protein complex	nucleic acid binding|protein binding|protein methyltransferase activity				0						CTGGAACCAGGGGAAAAAACC	0.388000													3	38					0	0	6.4e-05	0	0
DSCAM	1826	broad.mit.edu	37	21	41711310	41711310	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr21:41711310C>T	uc002yyq.1	-	7	1695	c.1243G>A	c.(1243-1245)GAA>AAA	p.E415K	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	415	Extracellular (Potential).|Ig-like C2-type 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				ACCACCTTTTCACTAAAGGCA	0.443000													6	8					0	0	3.59834e-05	0	0
AIRE	326	broad.mit.edu	37	21	45706946	45706946	+	Silent	SNP	G	A	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr21:45706946G>A	uc002zei.2	+	3	520	c.393G>A	c.(391-393)AAG>AAA	p.K131K		NM_000383	NP_000374	O43918	AIRE_HUMAN	autoimmune regulator isoform 1	131					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			skin(1)	1				Colorectal(79;0.0806)		TCCCCACCAAGAGGAAGGCCT	0.697000									Autoimmune_PolyEndocrinopathy_Candidiasis_Ectodermal_Dystrophy				5	17					0	0	3.59834e-05	0	0
CECR1	51816	broad.mit.edu	37	22	17688079	17688079	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr22:17688079C>T	uc002zmk.1	-	2	636	c.424G>A	c.(424-426)GGG>AGG	p.G142R	CECR1_uc010gqu.1_Missense_Mutation_p.G142R|CECR1_uc011agi.1_Missense_Mutation_p.G100R|CECR1_uc011agj.1_Missense_Mutation_p.G100R	NM_017424	NP_059120	Q9NZK5	CECR1_HUMAN	cat eye syndrome critical region protein 1	142	PRB domain.				adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			ovary(1)	1		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)				TGCATGATCCCCCTTGGGGTG	0.532000													45	15					0	0	0.000147903	0	0
TFIP11	24144	broad.mit.edu	37	22	26894937	26894937	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr22:26894937C>G	uc003acr.2	-	9	1708	c.1334G>C	c.(1333-1335)TGC>TCC	p.C445S	TFIP11_uc003acs.2_Missense_Mutation_p.C445S|TFIP11_uc003act.2_Missense_Mutation_p.C445S	NM_012143	NP_036275	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	445					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity				0						GCCATAAGTGCAGTCCTGAGG	0.557000													16	60					0	0	3.45872e-05	0	0
HMGXB4	10042	broad.mit.edu	37	22	35658400	35658401	+	Nonsense_Mutation	DNP	CC	AA	AA			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr22:35658400_35658401CC>AA	uc003anl.2	+	2	191_192	c.17_18CC>AA	c.(16-18)TCC>TAA	p.S6*	HMGXB4_uc011amh.1_Intron|HMGXB4_uc003ank.2_5'UTR	NM_001003681	NP_001003681	Q9UGU5	HMGX4_HUMAN	high-mobility group protein 2-like 1	6					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|skin(1)	2						TATGATGACTCCGTGAAGAAAG	0.505000													7	147					0	0	6.4e-05	0	0
CACNG2	10369	broad.mit.edu	37	22	36983595	36983596	+	Splice_Site	DNP	CC	AA	AA			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr22:36983595_36983596CC>AA	uc003aps.1	-	2	494	c.212_splice	c.e2-1	p.G71_splice		NM_006078	NP_006069	Q9Y698	CCG2_HUMAN	voltage-dependent calcium channel gamma-2						membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0						TTTGAAATTCCCTGCAAAACAA	0.485000													8	151					0	0	6.4e-05	0	0
IMPG2	50939	broad.mit.edu	37	3	100976421	100976422	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr3:100976421_100976422CC>AA	uc003duq.1	-	10	1307_1308	c.1104_1105GG>TT	c.(1102-1107)CTGGGG>CTTTGG	p.G369W	IMPG2_uc011bhe.1_Missense_Mutation_p.G232W	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	369	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GAAGAGTTCCCCAGCAAAAAAT	0.401000													7	79					0	0	6.4e-05	0	0
TXNDC6	347736	broad.mit.edu	37	3	138033207	138033208	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr3:138033207_138033208GG>TT	uc003esg.2	-	6	454_455	c.426_427CC>AA	c.(424-429)TCCCAT>TCAAAT	p.H143N	TXNDC6_uc003esd.1_RNA|TXNDC6_uc010huf.1_Missense_Mutation_p.H58N|TXNDC6_uc003ese.1_Missense_Mutation_p.H82N	NM_178130	NP_835231	Q86XW9	TXND6_HUMAN	thioredoxin domain containing 6	143					cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	cytoplasm|cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			breast(3)|ovary(1)|pancreas(1)	5						TTCTTTCCATGGGAAACACATT	0.347000													13	368					0	0	6.4e-05	0	0
PIK3CB	5291	broad.mit.edu	37	3	138452272	138452273	+	Missense_Mutation	DNP	CC	AA	AA	rs147232279		TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr3:138452272_138452273CC>AA	uc011bmq.1	-	6	980_981	c.980_981GG>TT	c.(979-981)TGG>TTT	p.W327F		NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	327					activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						TGTTATTTTCCCAAACATGCTG	0.292000													10	187					0	0	6.4e-05	0	0
THAP9	79725	broad.mit.edu	37	4	83839499	83839499	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr4:83839499A>G	uc003hnt.2	+	5	2253	c.2134A>G	c.(2134-2136)AGG>GGG	p.R712G	THAP9_uc003hns.1_Missense_Mutation_p.R568G|THAP9_uc003hnu.1_RNA|THAP9_uc003hnv.2_Missense_Mutation_p.R429G	NM_024672	NP_078948	Q9H5L6	THAP9_HUMAN	THAP domain containing 9	712							DNA binding|metal ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	5		Hepatocellular(203;0.114)				GTCAGATCATAGGCGAAATCT	0.423000													3	64					0	0	6.4e-05	0	0
GPM6A	2823	broad.mit.edu	37	4	176561960	176561960	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr4:176561960C>T	uc003iuf.2	-	5	1366	c.562G>A	c.(562-564)GAA>AAA	p.E188K	GPM6A_uc011ckj.1_Missense_Mutation_p.E181K|GPM6A_uc003iug.2_Missense_Mutation_p.E188K|GPM6A_uc003iuh.2_Missense_Mutation_p.E177K	NM_201591	NP_963885	P51674	GPM6A_HUMAN	glycoprotein M6A isoform 2	188	Extracellular (Potential).					cell surface|integral to membrane					0		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		ATTTTCTTTTCCTCTCCAATT	0.338000													10	21					0	0	6.40141e-05	0	0
HMGCR	3156	broad.mit.edu	37	5	74645947	74645948	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr5:74645947_74645948CC>AA	uc003kdp.2	+	7	793_794	c.637_638CC>AA	c.(637-639)CCA>AAA	p.P213K	HMGCR_uc011cst.1_Missense_Mutation_p.P233K|HMGCR_uc003kdq.2_Missense_Mutation_p.P213K|HMGCR_uc010izn.1_Missense_Mutation_p.P53K	NM_000859	NP_000850	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	213	Helical; (Potential).				cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			ovary(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	GACTTTCTTCCCAGCTTGTGTG	0.396000													14	362					0	0	6.4e-05	0	0
PCDHB4	56131	broad.mit.edu	37	5	140502272	140502272	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr5:140502272T>A	uc003lip.1	+	1	692	c.692T>A	c.(691-693)ATC>AAC	p.I231N		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	231	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGAATCCTGATCATGGACATC	0.537000													12	53					0	0	1.49906e-05	0	0
BTN3A2	11118	broad.mit.edu	37	6	26369000	26369000	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr6:26369000C>T	uc010jqh.1	+	4	552	c.293C>T	c.(292-294)TCG>TTG	p.S98L	BTN3A2_uc003nho.1_Missense_Mutation_p.S96L|BTN3A2_uc003nhp.2_Missense_Mutation_p.S98L|BTN3A2_uc011dkd.1_Missense_Mutation_p.S56L|BTN3A2_uc011dke.1_Missense_Mutation_p.S75L|BTN3A2_uc010jqi.1_Missense_Mutation_p.S96L	NM_007047	NP_008978	P78410	BT3A2_HUMAN	butyrophilin, subfamily 3, member A2 precursor	98	Ig-like V-type.|Extracellular (Potential).					integral to membrane					0						GGGAGAACTTCGATTCTGCGG	0.512000													7	32					0	0	0.00010058	0	0
TFAP2D	83741	broad.mit.edu	37	6	50712873	50712873	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr6:50712873C>T	uc003paf.2	+	6	1449	c.937C>T	c.(937-939)CCA>TCA	p.P313S	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	313	H-S-H (helix-span-helix), dimerization.						DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					AACAGAGTTTCCAGCCAAAGC	0.453000													18	19					0	0	9.7654e-05	0	0
KCTD7	154881	broad.mit.edu	37	7	66104168	66104168	+	Silent	SNP	C	T	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr7:66104168C>T	uc003tve.2	+	4	981	c.819C>T	c.(817-819)AAC>AAT	p.N273N	RABGEF1_uc003tvf.2_Intron|KCTD7_uc003tvd.3_Silent_p.N273N	NM_153033	NP_694578	Q96MP8	KCTD7_HUMAN	potassium channel tetramerisation domain	273						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)	3						ACCTCGTGAACCACTACTACT	0.577000													12	32					0	0	0.00010058	0	0
TFR2	7036	broad.mit.edu	37	7	100226876	100226876	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr7:100226876C>T	uc003uvv.1	-	10	1431	c.1390G>A	c.(1390-1392)GGC>AGC	p.G464S	TFR2_uc010lhc.1_Missense_Mutation_p.G5S|TFR2_uc003uvu.1_Missense_Mutation_p.G293S	NM_003227	NP_003218	Q9UP52	TFR2_HUMAN	transferrin receptor 2	464	Extracellular (Potential).				cellular iron ion homeostasis|iron ion transport|proteolysis	cytoplasm|integral to plasma membrane	peptidase activity|transferrin receptor activity			ovary(1)|pancreas(1)	2	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CTGACCTTACCGTTGCTCACC	0.547000													10	76					0	0	0.00010058	0	0
Unknown	0	broad.mit.edu	37	7	100551902	100551903	+	RNA	DNP	GG	TT	TT			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr7:100551902_100551903GG>TT	uc003uxk.1	+	1		c.1153_1154GG>TT			uc003uxl.1_Missense_Mutation_p.R118I					Homo sapiens MUC3B mRNA for intestinal mucin, partial cds.																		TCTTTCACTAGGGGAAGTACGT	0.436000													16	593					0	0	6.4e-05	0	0
NRCAM	4897	broad.mit.edu	37	7	107823349	107823349	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr7:107823349C>T	uc003vfb.2	-	23	2791	c.2320G>A	c.(2320-2322)GAA>AAA	p.E774K	NRCAM_uc003vfc.2_Missense_Mutation_p.E758K|NRCAM_uc011kmk.1_Missense_Mutation_p.E769K|NRCAM_uc003vfd.2_Missense_Mutation_p.E750K|NRCAM_uc003vfe.2_Missense_Mutation_p.E750K	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	774	Fibronectin type-III 2.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						CCATTAGATTCGAAACCATTC	0.413000													6	47					0	0	8.12818e-05	0	0
TSGA14	95681	broad.mit.edu	37	7	130067831	130067832	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr7:130067831_130067832GG>TT	uc003vpz.2	-	2	108_109	c.61_62CC>AA	c.(61-63)CCA>AAA	p.P21K	TSGA14_uc010lmf.2_5'UTR|TSGA14_uc003vqa.2_Missense_Mutation_p.P21K|TSGA14_uc011kpg.1_Missense_Mutation_p.P21K|TSGA14_uc003vqb.1_RNA	NM_018718	NP_061188	Q9BYV8	CEP41_HUMAN	testis specific, 14	21					G2/M transition of mitotic cell cycle	centrosome|cytosol					0	Melanoma(18;0.0435)					CTGGTATCTTGGGTTCTGTGGT	0.312000													19	649					0	0	6.4e-05	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				74	11					0	0	0.000147903	0	0
TRY6	154754	broad.mit.edu	37	7	142481789	142481789	+	Silent	SNP	T	C	C	rs140267598	by1000genomes	TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr7:142481789T>C	uc011ksq.1	+	4	551	c.468T>C	c.(466-468)GAT>GAC	p.D156D	uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|uc003wan.1_Intron	NR_001296				SubName: Full=Protease, serine, 3; Flags: Fragment;												0						ACTACCCAGATGAGCTGCAGT	0.488000													3	7					0	0	1.23904e-05	0	0
TPK1	27010	broad.mit.edu	37	7	144320354	144320355	+	Splice_Site	DNP	CC	AA	AA			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr7:144320354_144320355CC>AA	uc003weq.2	-	6	362	c.259_splice	c.e6-1	p.G87_splice	TPK1_uc003weo.2_Splice_Site_p.G82_splice|TPK1_uc003wep.2_Splice_Site|TPK1_uc003wer.2_Splice_Site_p.G87_splice|TPK1_uc003wes.2_Splice_Site	NM_022445	NP_071890	Q9H3S4	TPK1_HUMAN	thiamin pyrophosphokinase 1 isoform a						thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity			ovary(2)	2					Thiamine(DB00152)	AGCTCACATCCCTATGTATTAA	0.312000													15	384					0	0	6.4e-05	0	0
CUL1	8454	broad.mit.edu	37	7	148457565	148457566	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr7:148457565_148457566CC>AA	uc010lpg.2	+	7	1292_1293	c.766_767CC>AA	c.(766-768)CCA>AAA	p.P256K	CUL1_uc003wey.2_Missense_Mutation_p.P256K|CUL1_uc003wez.2_Missense_Mutation_p.P146K	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	256					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			GCAGCAGAACCCAGTTACTGAA	0.332000													10	250					0	0	6.4e-05	0	0
ST18	9705	broad.mit.edu	37	8	53084780	53084780	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr8:53084780T>C	uc003xqz.2	-	5	797	c.641A>G	c.(640-642)AAA>AGA	p.K214R	ST18_uc011ldq.1_5'UTR|ST18_uc011ldr.1_Missense_Mutation_p.K179R|ST18_uc011lds.1_Missense_Mutation_p.K119R|ST18_uc003xra.2_Missense_Mutation_p.K214R|ST18_uc003xrb.2_Missense_Mutation_p.K214R	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	214						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TCTAGGTGGTTTGGTTTCTTC	0.408000													6	42					0	0	3.59834e-05	0	0
GGH	8836	broad.mit.edu	37	8	63948232	63948232	+	Silent	SNP	C	G	G			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr8:63948232C>G	uc003xuw.2	-	2	490	c.207G>C	c.(205-207)GCG>GCC	p.A69A		NM_003878	NP_003869	Q92820	GGH_HUMAN	gamma-glutamyl hydrolase precursor	69	Gamma-glutamyl hydrolase.				glutamine metabolic process	extracellular space|lysosome|melanosome	gamma-glutamyl-peptidase activity				0	Breast(64;0.0716)	all_cancers(86;0.189)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.131)			Folic Acid(DB00158)|L-Glutamic Acid(DB00142)	GTACAACTCTCGCACCTGCAG	0.284000													3	85					0	0	3.59834e-05	0	0
CCNE2	9134	broad.mit.edu	37	8	95897418	95897419	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr8:95897418_95897419CC>AA	uc003yhc.2	-	9	816_817	c.707_708GG>TT	c.(706-708)TGG>TTT	p.W236F	CCNE2_uc003yhd.2_Missense_Mutation_p.W236F	NM_057749	NP_477097	O96020	CCNE2_HUMAN	cyclin E2	236					cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	cytosol|nucleoplasm	protein kinase binding				0	Breast(36;8.75e-07)					GACAAAGTTCCCATTTTAAAGC	0.366000													11	322					0	0	6.4e-05	0	0
ZNF34	80778	broad.mit.edu	37	8	145999522	145999522	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr8:145999522C>G	uc003zdy.3	-	6	914	c.812G>C	c.(811-813)CGG>CCG	p.R271P	ZNF34_uc010mgb.2_Missense_Mutation_p.R168P|ZNF34_uc003zdx.3_Missense_Mutation_p.R250P	NM_030580	NP_085057	Q8IZ26	ZNF34_HUMAN	zinc finger protein 34	271	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.221)	OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;5.18e-38)|all cancers(56;4.41e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.0179)		AGTGTGAAGCCGCTGATGCTT	0.453000													3	60					0	0	6.4e-05	0	0
KIAA1797	54914	broad.mit.edu	37	9	20820362	20820363	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr9:20820362_20820363GG>AA	uc003zog.1	+	15	1963_1964	c.1600_1601GG>AA	c.(1600-1602)GGA>AAA	p.G534K	KIAA1797_uc003zoh.1_5'UTR	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	534						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		ACAACTACTTGGAACCACACCA	0.376000													33	16					0	0	6.4e-05	0	0
ROR2	4920	broad.mit.edu	37	9	94486904	94486904	+	Silent	SNP	G	A	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr9:94486904G>A	uc004arj.1	-	9	2071	c.1872C>T	c.(1870-1872)TAC>TAT	p.Y624Y	ROR2_uc004ari.1_Silent_p.Y484Y	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	624	Cytoplasmic (Potential).|Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						TCAGCTTGTCGTACACTAGCA	0.577000													13	59					0	0	0.000151284	0	0
KCNT1	57582	broad.mit.edu	37	9	138670652	138670652	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr9:138670652G>A	uc011mdq.1	+	23	2787	c.2713G>A	c.(2713-2715)GTG>ATG	p.V905M	KCNT1_uc011mdr.1_Missense_Mutation_p.V732M|KCNT1_uc010nbf.2_Missense_Mutation_p.V860M|KCNT1_uc004cgo.1_Missense_Mutation_p.V654M	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	905						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		CATCGTCAACGTGCAGACCAT	0.637000													11	10					0	0	6.40141e-05	0	0
MAGEB3	4114	broad.mit.edu	37	X	30254167	30254167	+	Silent	SNP	C	T	T			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chrX:30254167C>T	uc004dca.1	+	5	863	c.126C>T	c.(124-126)TCC>TCT	p.S42S		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	42											0						CCTTTTCATCCCCTCTTATTT	0.498000													11	8					0	0	6.40141e-05	0	0
ARMCX5	64860	broad.mit.edu	37	X	101857274	101857274	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chrX:101857274G>A	uc004ejg.2	+	6	1086	c.205G>A	c.(205-207)GAG>AAG	p.E69K	ARMCX5_uc004ejh.2_Missense_Mutation_p.E69K	NM_022838	NP_073749	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	69							binding			ovary(1)	1						GACCTACAGGGAGGCTATGGC	0.507000													13	46					0	0	0.000151284	0	0
DOCK11	139818	broad.mit.edu	37	X	117752567	117752567	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chrX:117752567T>C	uc004eqp.2	+	31	3410	c.3347T>C	c.(3346-3348)GTT>GCT	p.V1116A	DOCK11_uc004eqq.2_Missense_Mutation_p.V895A	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1116					blood coagulation	cytosol	GTP binding			ovary(3)	3						CACTTCTTGGTTGGTCTACTT	0.318000													28	52					0	0	3.70037e-05	0	0
GRIA3	2892	broad.mit.edu	37	X	122551412	122551412	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chrX:122551412G>A	uc004etq.3	+	12	1953	c.1660G>A	c.(1660-1662)GAA>AAA	p.E554K	GRIA3_uc004etr.3_Missense_Mutation_p.E554K|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_Missense_Mutation_p.E538K	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	554	Helical; (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	CCTGGCTTATGAAATCTGGAT	0.428000													88	135					0	0	0.000147903	0	0
IGSF1	3547	broad.mit.edu	37	X	130411117	130411117	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chrX:130411117G>C	uc004ewd.2	-	14	2642	c.2404C>G	c.(2404-2406)CCC>GCC	p.P802A	IGSF1_uc004ewe.3_Missense_Mutation_p.P796A|IGSF1_uc004ewf.2_Missense_Mutation_p.P782A	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	802	Extracellular (Potential).|Ig-like C2-type 8.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						TGCTGGTGGGGGGTGGAGCAA	0.507000													4	129					0	0	3.59834e-05	0	0
PPFIA4	8497	broad.mit.edu	37	1	203008129	203008129	+	Frame_Shift_Del	DEL	C	-	-			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr1:203008129delC	uc009xaj.2	+	6	434	c.434delC	c.(433-435)ACCfs	p.T145fs				O75335	LIPA4_HUMAN	SubName: Full=Liprin alpha4;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						GCCCTGCCAACCCCCACCATG	0.642											OREG0014109	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
CD44	960	broad.mit.edu	37	11	35160867	35160867	+	Frame_Shift_Del	DEL	G	-	-			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr11:35160867delG	uc001mvu.2	+	1	451	c.17delG	c.(16-18)TGGfs	p.W6fs	CD44_uc001mvv.2_Frame_Shift_Del_p.W6fs|CD44_uc001mvw.2_Frame_Shift_Del_p.W6fs|CD44_uc001mvx.2_Frame_Shift_Del_p.W6fs|CD44_uc001mvy.2_Frame_Shift_Del_p.W6fs|CD44_uc001mwc.3_Frame_Shift_Del_p.W6fs|CD44_uc010rer.1_Frame_Shift_Del_p.W6fs|CD44_uc009ykh.2_RNA	NM_000610	NP_000601	P16070	CD44_HUMAN	CD44 antigen isoform 1 precursor	6					cell-cell adhesion|cell-matrix adhesion|interferon-gamma-mediated signaling pathway|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation	cell surface|Golgi apparatus|integral to plasma membrane	collagen binding|hyaluronic acid binding|receptor activity			pancreas(1)	1	all_cancers(35;0.212)|all_lung(20;0.0874)|all_epithelial(35;0.112)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.00731)		Hyaluronidase(DB00070)	AAGTTTTGGTGGCACGCAGCC	0.716													2	4	---	---	---	---					
CDH19	28513	broad.mit.edu	37	18	64197127	64197128	+	Frame_Shift_Ins	INS	-	G	G			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr18:64197127_64197128insG	uc002lkc.1	-	9	1550_1551	c.1412_1413insC	c.(1411-1413)TCTfs	p.S471fs	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Frame_Shift_Ins_p.S471fs	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	471	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				CATAGTATTGAGAGAACTCAGG	0.317													25	92	---	---	---	---					
PXDN	7837	broad.mit.edu	37	2	1637997	1637998	+	Frame_Shift_Ins	INS	-	TT	TT			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr2:1637997_1637998insTT	uc002qxa.2	-	23	4482_4483	c.4418_4419insAA	c.(4417-4419)AAGfs	p.K1473fs		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1473					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CCTCCGCCCTCTTCTGTAAGCA	0.639													2	4	---	---	---	---					
ETV7	51513	broad.mit.edu	37	6	36341294	36341294	+	Frame_Shift_Del	DEL	C	-	-	rs3213530	byFrequency	TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr6:36341294delC	uc003omb.2	-	4	518	c.369delG	c.(367-369)GGAfs	p.G123fs	ETV7_uc003olz.1_Frame_Shift_Del_p.G123fs|ETV7_uc003oma.1_Frame_Shift_Del_p.G68fs|ETV7_uc010jwg.2_RNA|ETV7_uc003omc.2_Frame_Shift_Del_p.G68fs|ETV7_uc010jwj.2_Frame_Shift_Del_p.G64fs|ETV7_uc010jwh.2_Frame_Shift_Del_p.G42fs|ETV7_uc010jwi.2_Frame_Shift_Del_p.G123fs|ETV7_uc011dtl.1_5'UTR	NM_016135	NP_057219	Q9Y603	ETV7_HUMAN	ets variant 7	123					organ morphogenesis|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						CAAAAAAGGGCCCACACACCA	0.627													2	4	---	---	---	---					
EIF3B	8662	broad.mit.edu	37	7	2419064	2419064	+	Frame_Shift_Del	DEL	G	-	-			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chr7:2419064delG	uc003slx.2	+	18	2460	c.2377delG	c.(2377-2379)GACfs	p.D793fs	EIF3B_uc003sly.2_Frame_Shift_Del_p.D793fs|EIF3B_uc003sma.2_Frame_Shift_Del_p.D521fs|EIF3B_uc003smb.2_RNA	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	793					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		CAACGTGGACGACTGGGAAGA	0.602													2	4	---	---	---	---					
LDOC1	23641	broad.mit.edu	37	X	140271057	140271063	+	Frame_Shift_Del	DEL	CGGGCAG	-	-			TCGA-D3-A3CE-06A-11D-A19A-08	TCGA-D3-A3CE-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	dba28b3d-826a-429e-849f-740d9a8344cb	1b6a33a9-bfd6-4890-afd4-63723ccee5ff	g.chrX:140271057_140271063delCGGGCAG	uc004fbj.2	-	1	248_254	c.144_150delCTGCCCG	c.(142-150)AGCTGCCCGfs	p.S48fs		NM_012317	NP_036449	O95751	LDOC1_HUMAN	leucine zipper, down-regulated in cancer 1	48_50					negative regulation of cell proliferation	nucleus	protein binding				0	Acute lymphoblastic leukemia(192;7.65e-05)					GGAAGGGCACCGGGCAGCTCGGCGGAC	0.638													8	12	---	---	---	---					
