Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
UBE2J2	118424	broad.mit.edu	37	1	1192648	1192648	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:1192648G>A	uc001adn.2	-	4	525	c.215C>T	c.(214-216)CCT>CTT	p.P72L	UBE2J2_uc001adm.2_Missense_Mutation_p.P37L|UBE2J2_uc001ado.2_Missense_Mutation_p.P88L|UBE2J2_uc001adp.2_Missense_Mutation_p.P72L|UBE2J2_uc001adq.2_Missense_Mutation_p.P20L|UBE2J2_uc001adr.2_Missense_Mutation_p.P20L|UBE2J2_uc001ads.2_Missense_Mutation_p.P20L	NM_194458	NP_919440	Q8N2K1	UB2J2_HUMAN	ubiquitin conjugating enzyme E2, J2 isoform 3	72	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.66e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.53e-21)|Colorectal(212;0.00019)|COAD - Colon adenocarcinoma(227;0.000215)|Kidney(185;0.00255)|BRCA - Breast invasive adenocarcinoma(365;0.00266)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0371)|Lung(427;0.205)		AGGTTTGAAAGGAAATTCTCT	0.512													13	60					0	0	1	0	0
MMEL1	79258	broad.mit.edu	37	1	2524340	2524340	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:2524340G>A	uc001ajy.2	-	20	2147	c.1933C>T	c.(1933-1935)CGG>TGG	p.R645W	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	645	Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		GACTGCTCCCGGAAGTGCTGG	0.607													23	131					0	0	1	0	0
LRRC47	57470	broad.mit.edu	37	1	3703748	3703748	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:3703748C>T	uc001akx.1	-	2	770	c.742G>A	c.(742-744)GGC>AGC	p.G248S		NM_020710	NP_065761	Q8N1G4	LRC47_HUMAN	leucine rich repeat containing 47	248					translation		phenylalanine-tRNA ligase activity|RNA binding			large_intestine(1)|ovary(1)	2	all_cancers(77;0.0375)|Ovarian(185;0.0634)|all_lung(157;0.208)|Lung NSC(156;0.21)	all_epithelial(116;1.34e-16)|all_lung(118;2.53e-06)|Lung NSC(185;0.00028)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;5.49e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		GTCTGGCAGCCGCTGACCATC	0.582													3	79					0	0	1	0	0
KCNAB2	8514	broad.mit.edu	37	1	6147560	6147560	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:6147560C>T	uc009vlv.1	+	8	495	c.360C>T	c.(358-360)TTC>TTT	p.F120F	KCNAB2_uc001alv.1_Silent_p.F120F|KCNAB2_uc001alw.1_Silent_p.F106F|KCNAB2_uc001alx.1_Silent_p.F120F|KCNAB2_uc001aly.1_Silent_p.F153F|KCNAB2_uc009vlw.1_Silent_p.F53F|KCNAB2_uc001alu.2_Silent_p.F120F	NM_003636	NP_003627	Q13303	KCAB2_HUMAN	potassium voltage-gated channel, shaker-related	120						cytoplasm|integral to membrane|juxtaparanode region of axon	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity				0	Ovarian(185;0.0634)	all_cancers(23;5.85e-39)|all_epithelial(116;4.88e-22)|all_lung(118;4.21e-08)|Lung NSC(185;9.77e-07)|all_hematologic(16;2.78e-06)|all_neural(13;3.18e-06)|Acute lymphoblastic leukemia(12;0.000272)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00106)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;6.9e-37)|GBM - Glioblastoma multiforme(13;8.8e-31)|OV - Ovarian serous cystadenocarcinoma(86;1.45e-19)|Colorectal(212;2.46e-07)|COAD - Colon adenocarcinoma(227;2.07e-05)|Kidney(185;7.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00131)|BRCA - Breast invasive adenocarcinoma(365;0.00133)|STAD - Stomach adenocarcinoma(132;0.00391)|READ - Rectum adenocarcinoma(331;0.0649)		CCAAGATCTTCTGGGGCGGAA	0.642													52	50					0	0	1	0	0
PER3	8863	broad.mit.edu	37	1	7895934	7895934	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:7895934C>T	uc001aoo.2	+	19	3475	c.3300C>T	c.(3298-3300)GCC>GCT	p.A1100A	PER3_uc001aop.2_Silent_p.A1109A|PER3_uc010nzw.1_Silent_p.A789A	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	1100					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		CTAATGTCGCCGAAGAGCCCA	0.423													17	39					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8418550	8418550	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:8418550G>A	uc001ape.2	-	21	4855	c.4045C>T	c.(4045-4047)CGG>TGG	p.R1349W	RERE_uc001apf.2_Missense_Mutation_p.R1349W|RERE_uc001apd.2_Missense_Mutation_p.R795W	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	1349					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		GCGCTGTGCCGGGCAAAGTGC	0.692													9	18					0	0	1	0	0
H6PD	9563	broad.mit.edu	37	1	9305520	9305520	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:9305520T>A	uc001apt.2	+	2	800	c.527T>A	c.(526-528)TTT>TAT	p.F176Y		NM_004285	NP_004276	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase precursor	176	Glucose 1-dehydrogenase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding				0	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	GAGAAACCCTTTGGCCATGAC	0.592													65	43					0	0	1	0	0
TMEM201	199953	broad.mit.edu	37	1	9661186	9661186	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:9661186C>T	uc001apz.2	+	5	642	c.630C>T	c.(628-630)TCC>TCT	p.S210S	TMEM201_uc001apy.2_Silent_p.S210S	NM_001130924	NP_001124396	Q5SNT2	TM201_HUMAN	transmembrane protein 201 isoform 1	210						integral to membrane|nuclear inner membrane					0	all_lung(157;0.222)	all_epithelial(116;2.09e-14)|Renal(390;0.000469)|all_lung(118;0.000521)|Lung NSC(185;0.000744)|Colorectal(325;0.0062)|Breast(348;0.0157)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.5e-08)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|STAD - Stomach adenocarcinoma(132;0.00345)|READ - Rectum adenocarcinoma(331;0.0419)		CCGTGAAGTCCCCGGTCCAGG	0.657													76	83					0	0	1	0	0
C1orf127	148345	broad.mit.edu	37	1	11007824	11007825	+	Nonsense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:11007824_11007825GG>AA	uc010oao.1	-	8	1925_1926	c.1920_1921CC>TT	c.(1918-1923)CTCCAG>CTTTAG	p.Q641*	C1orf127_uc001arr.1_Nonsense_Mutation_p.Q623*|C1orf127_uc001ars.1_Nonsense_Mutation_p.Q615*	NM_173507	NP_775778	B7ZLG7	B7ZLG7_HUMAN	hypothetical protein LOC148345	641										ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		AGCTCCTGCTGGAGTGAGGCCC	0.629													8	20					0	0	1	0	0
PLOD1	5351	broad.mit.edu	37	1	12027068	12027068	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:12027068C>T	uc001atm.2	+	16	1766	c.1675C>T	c.(1675-1677)CCC>TCC	p.P559S	PLOD1_uc010obb.1_Missense_Mutation_p.P606S	NM_000302	NP_000293	Q02809	PLOD1_HUMAN	lysyl hydroxylase 1 precursor	559					epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity			ovary(2)|breast(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)	CTATTGGTTCCCCATCTTCAC	0.607													85	83					0	0	1	0	0
PRAMEF12	390999	broad.mit.edu	37	1	12835108	12835108	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:12835108G>T	uc001aui.2	+	1	125	c.98G>T	c.(97-99)AGG>ATG	p.R33M		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	33										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GAGCTGCCCAGGGAGCTCTTT	0.622													48	53					2.69953e-25	2.77115e-25	1	1	0
PRAMEF11	440560	broad.mit.edu	37	1	12887399	12887399	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:12887399C>T	uc001auk.2	-	3	654	c.458G>A	c.(457-459)CGC>CAC	p.R153H		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	153											0						TCTGATATTGCGGAAGGGCAT	0.468													81	313					0	0	1	0	0
PRAMEF16	654348	broad.mit.edu	37	1	13497634	13497634	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:13497634G>A	uc001aux.2	+	3	961	c.931G>A	c.(931-933)GAG>AAG	p.E311K		NM_001045480	NP_001038945	Q5VWM1	PRA16_HUMAN	PRAME family member 16	311											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCAGGACATGGAGTGTCTGTC	0.483													23	82					0	0	1	0	0
DDI2	84301	broad.mit.edu	37	1	15960018	15960018	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:15960018C>T	uc001awx.1	+	4	686	c.590C>T	c.(589-591)CCC>CTC	p.P197L	DDI2_uc001aww.2_Missense_Mutation_p.P197L|DDI2_uc009voj.1_5'UTR	NM_032341	NP_115717	Q5TDH0	DDI2_HUMAN	DNA-damage inducible protein 2	197					proteolysis		aspartic-type endopeptidase activity				0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		TCTGCTGATCCCTTTGACCTT	0.438													211	144					0	0	1	0	0
FAM131C	348487	broad.mit.edu	37	1	16362752	16362753	+	Nonsense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:16362752_16362753GG>AA	uc010obz.1	-	6	730_731	c.540_541CC>TT	c.(538-543)CCCCAG>CCTTAG	p.Q181*	CLCNKB_uc001axw.3_Intron	NM_182623	NP_872429	Q96AQ9	F131C_HUMAN	hypothetical protein LOC348487	181											0		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.32e-08)|COAD - Colon adenocarcinoma(227;5.56e-06)|BRCA - Breast invasive adenocarcinoma(304;9.12e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00656)|READ - Rectum adenocarcinoma(331;0.0649)		ACGATGCCCTGGGGGCTGTTCT	0.421													24	44					0	0	1	0	0
EPHA2	1969	broad.mit.edu	37	1	16464675	16464675	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:16464675G>A	uc001aya.1	-	5	1122	c.985C>T	c.(985-987)CCC>TCC	p.P329S	EPHA2_uc010oca.1_Missense_Mutation_p.P329S	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	329	Extracellular (Potential).|Fibronectin type-III 1.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	GGGGCGGAGGGGGGTCCTGCA	0.667													5	30					0	0	1	0	0
ARHGEF19	128272	broad.mit.edu	37	1	16535154	16535154	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:16535154C>T	uc001ayc.1	-	2	533	c.396G>A	c.(394-396)TCG>TCA	p.S132S	ARHGEF19_uc009voo.1_5'Flank|ARHGEF19_uc001ayb.1_5'Flank	NM_153213	NP_694945	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	132					regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			skin(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		ACTTCTTCTCCGAGCCGTGGC	0.672													10	24					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16892196	16892196	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:16892196C>T	uc009vos.1	-	28	4109	c.3221G>A	c.(3220-3222)TGC>TAC	p.C1074Y	uc001ayw.2_5'Flank	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	1074	NBPF 7.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		ATAGGGCAGGCAGGAGTCAGG	0.478													10	771					0	0	1	0	0
CROCC	9696	broad.mit.edu	37	1	17279938	17279938	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:17279938G>A	uc001azt.2	+	21	3217	c.3148G>A	c.(3148-3150)GAC>AAC	p.D1050N	CROCC_uc009voz.1_Missense_Mutation_p.D649N|CROCC_uc001azu.2_Missense_Mutation_p.D353N	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	1050	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GCAGGAGCGCGACGAGGGCCT	0.582													19	33					0	0	1	0	0
IGSF21	84966	broad.mit.edu	37	1	18691786	18691786	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:18691786G>A	uc001bau.1	+	6	993	c.610G>A	c.(610-612)GGC>AGC	p.G204S	IGSF21_uc001bav.1_Missense_Mutation_p.G25S	NM_032880	NP_116269	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21 precursor	204						extracellular region				ovary(2)|large_intestine(1)|skin(1)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		TGCGAGCTCCGGCCCCCTACA	0.582													32	59					0	0	1	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18809476	18809477	+	Missense_Mutation	DNP	CC	AG	AG			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:18809476_18809477CC>AG	uc001bax.2	+	1	2053_2054	c.2001_2002CC>AG	c.(1999-2004)GACCGC>GAAGGC	p.667_668DR>EG	KLHDC7A_uc009vpg.2_Missense_Mutation_p.449_450DR>EG	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	667_668	Kelch 5.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGCAAGGACCGCACGGCCGA	0.683													15	33					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19166189	19166189	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:19166189G>A	uc001bba.1	-	6	2425	c.2424C>T	c.(2422-2424)TTC>TTT	p.F808F		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	808	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	ACTTGGGGCCGAAGTAGCCCA	0.597													21	44					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19433144	19433144	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:19433144C>T	uc001bbi.2	-	83	12316	c.12312G>A	c.(12310-12312)AGG>AGA	p.R4104R	UBR4_uc001bbg.2_5'Flank|UBR4_uc001bbh.2_5'Flank	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	4104					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		ACTGTTTCCACCTCCACACAT	0.552													116	124					0	0	1	0	0
PLA2G2F	64600	broad.mit.edu	37	1	20466008	20466008	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:20466008G>A	uc009vpp.1	+	1	186	c.88G>A	c.(88-90)GGG>AGG	p.G30R		NM_022819	NP_073730	Q9BZM2	PA2GF_HUMAN	phospholipase A2, group IIF	Error:Variant_position_missing_in_Q9BZM2_after_alignment					lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity	p.G30V(1)		ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000247)|Lung NSC(340;0.000285)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.000524)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		CCCACGCTTCGGGGCCTCCTG	0.602													4	4					0	0	1	0	0
PLA2G2C	391013	broad.mit.edu	37	1	20490512	20490512	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:20490512C>T	uc009vpq.1	-	3	425	c.425G>A	c.(424-426)AGG>AAG	p.R142K		NM_001105572	NP_001099042			phospholipase A2, group IIC precursor												0		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.14e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.000171)|GBM - Glioblastoma multiforme(114;0.000528)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TCTGCCACACCTGGGCTGGCT	0.393													9	8					0	0	1	0	0
EPHA8	2046	broad.mit.edu	37	1	22923846	22923846	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:22923846A>G	uc001bfx.1	+	10	1932	c.1807A>G	c.(1807-1809)AAG>GAG	p.K603E		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	603	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CCCCCCGGGAAAGCTCCCAGA	0.642													38	79					0	0	1	0	0
KDM1A	23028	broad.mit.edu	37	1	23382520	23382520	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:23382520T>A	uc001bgi.2	+	6	1068	c.919T>A	c.(919-921)TTG>ATG	p.L307M	KDM1A_uc001bgj.2_Missense_Mutation_p.L327M	NM_015013	NP_055828	O60341	KDM1A_HUMAN	lysine-specific histone demethylase 1 isoform b	307	FAD (Potential).|Demethylase activity.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2						TGTCACACTTTTGGAAGCCAG	0.368													20	49					0	0	1	0	0
HNRNPR	10236	broad.mit.edu	37	1	23664332	23664332	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:23664332C>T	uc001bgr.3	-	4	458	c.299G>A	c.(298-300)GGA>GAA	p.G100E	HNRNPR_uc001bgp.3_Missense_Mutation_p.G100E|HNRNPR_uc009vqk.2_5'UTR|HNRNPR_uc001bgs.3_5'UTR|HNRNPR_uc010odw.1_Missense_Mutation_p.G100E|HNRNPR_uc010odx.1_5'UTR|HNRNPR_uc009vql.2_5'UTR	NM_005826	NP_005817	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	100	Asp/Glu-rich (acidic).					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		CTTCATAACTCCACATAAAAA	0.363													55	39					0	0	1	0	0
PAFAH2	5051	broad.mit.edu	37	1	26301045	26301045	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:26301045G>A	uc001bld.3	-	9	1035	c.855C>T	c.(853-855)TTC>TTT	p.F285F	PAFAH2_uc001ble.3_Silent_p.F285F	NM_000437	NP_000428	Q99487	PAFA2_HUMAN	platelet-activating factor acetylhydrolase 2	285					lipid catabolic process	cytoplasm	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			ovary(2)	2		Colorectal(325;3.47e-05)|Lung NSC(340;6.23e-05)|all_lung(284;9.48e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-25)|Colorectal(126;3.57e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00155)|GBM - Glioblastoma multiforme(114;0.00717)|READ - Rectum adenocarcinoma(331;0.0649)		CCATTGTCTGGAATTTCTCAG	0.473													15	39					0	0	1	0	0
ZNF683	257101	broad.mit.edu	37	1	26691026	26691026	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:26691026G>A	uc001bmg.1	-	4	1129	c.1011C>T	c.(1009-1011)CTC>CTT	p.L337L	ZNF683_uc001bmh.1_Silent_p.L337L|ZNF683_uc009vsj.1_Silent_p.L337L	NM_173574	NP_775845	Q8IZ20	ZN683_HUMAN	zinc finger protein 683	337	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		CAGATACCTTGAGATTGGAGA	0.537													42	160					0	0	1	0	0
AHDC1	27245	broad.mit.edu	37	1	27875442	27875442	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:27875442G>T	uc009vsy.2	-	6	4154	c.3185C>A	c.(3184-3186)ACA>AAA	p.T1062K	AHDC1_uc009vsz.1_Missense_Mutation_p.T1062K	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1062							DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GGGCGAGACTGTGCTGGCCCG	0.607													6	2					0.00116845	0.00117181	1	1	0
SESN2	83667	broad.mit.edu	37	1	28595741	28595741	+	Silent	SNP	C	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:28595741C>A	uc001bps.2	+	2	491	c.138C>A	c.(136-138)GCC>GCA	p.A46A		NM_031459	NP_113647	P58004	SESN2_HUMAN	sestrin 2	46					cell cycle arrest	cytoplasm|nucleus				skin(3)|ovary(2)|pancreas(1)|lung(1)	7		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;4.76e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;2.98e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|READ - Rectum adenocarcinoma(331;0.0649)		GGCCCAGCGCCTTCATCCCCG	0.557													18	57					1.96292e-10	1.99733e-10	1	1	0
SDC3	9672	broad.mit.edu	37	1	31347415	31347415	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:31347415G>A	uc001bse.2	-	4	938	c.891C>T	c.(889-891)TTC>TTT	p.F297F	SDC3_uc001bsd.2_Silent_p.F239F	NM_014654	NP_055469	O75056	SDC3_HUMAN	syndecan 3	297	Extracellular (Potential).|Ser/Thr-rich (mucin-like).					integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)|Colorectal(325;0.0466)|all_neural(195;0.0966)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0197)|READ - Rectum adenocarcinoma(331;0.0649)		TTGTGGTCAGGAAGGTCTCTG	0.592													99	84					0	0	1	0	0
KIAA1522	57648	broad.mit.edu	37	1	33236792	33236792	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:33236792C>T	uc001bvv.2	+	6	1971	c.1835C>T	c.(1834-1836)TCC>TTC	p.S612F	KIAA1522_uc001bvu.1_Missense_Mutation_p.S671F|KIAA1522_uc010ohm.1_Missense_Mutation_p.S623F|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	612	Pro-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				GCCCCCTTCTCCCCACCTCCC	0.642													128	75					0	0	1	0	0
YARS	8565	broad.mit.edu	37	1	33282828	33282828	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:33282828G>A	uc001bvy.1	-	1	806	c.18C>T	c.(16-18)AGC>AGT	p.S6S	S100PBP_uc001bvz.2_5'Flank|S100PBP_uc001bwa.1_5'Flank|S100PBP_uc001bwb.1_5'Flank|S100PBP_uc001bwc.2_5'Flank	NM_003680	NP_003671	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	6					apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	TCTCTTCAGGGCTGGGAGCGT	0.652													43	80					0	0	1	0	0
TRIM62	55223	broad.mit.edu	37	1	33613051	33613051	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:33613051G>A	uc001bxb.2	-	5	1793	c.1155C>T	c.(1153-1155)GGC>GGT	p.G385G		NM_018207	NP_060677	Q9BVG3	TRI62_HUMAN	tripartite motif-containing 62	385	B30.2/SPRY.					intracellular	zinc ion binding				0		Myeloproliferative disorder(586;0.0393)				TGCAGTAGAAGCCGCGGCTGG	0.637													27	23					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34006261	34006261	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:34006261C>T	uc001bxn.1	-	59	9092	c.9063G>A	c.(9061-9063)GGG>GGA	p.G3021G	CSMD2_uc001bxm.1_Silent_p.G3165G	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3021	Sushi 23.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCACCACCTTCCCATTGGGGA	0.602													9	171					0	0	1	0	0
HMGB4	127540	broad.mit.edu	37	1	34330046	34330046	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:34330046G>A	uc001bxp.2	+	2	1997	c.254G>A	c.(253-255)CGG>CAG	p.R85Q	CSMD2_uc001bxm.1_Intron|CSMD2_uc001bxn.1_Intron|HMGB4_uc001bxq.2_Missense_Mutation_p.R11Q	NM_145205	NP_660206	Q8WW32	HMGB4_HUMAN	HMG2 like isoform 1	85						nucleus	DNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				AGGAAGAAACGGAGAAAGCGG	0.502													53	49					0	0	1	0	0
EIF2C3	192669	broad.mit.edu	37	1	36505490	36505490	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:36505490C>T	uc001bzp.2	+	15	2198	c.1942C>T	c.(1942-1944)CGG>TGG	p.R648W	EIF2C3_uc001bzq.2_Missense_Mutation_p.R414W	NM_024852	NP_079128	Q9H9G7	AGO3_HUMAN	eukaryotic translation initiation factor 2C, 3	648	Piwi.				mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CTCCATGGTCCGGGAACTTCT	0.483													20	66					0	0	1	0	0
INPP5B	3633	broad.mit.edu	37	1	38411978	38411978	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:38411978C>A	uc001ccg.1	-	2	97	c.3G>T	c.(1-3)ATG>ATT	p.M1I	INPP5B_uc009vvk.1_5'Flank|INPP5B_uc001cch.2_5'Flank	NM_005540	NP_005531	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	1					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			urinary_tract(1)	1	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CAGACTGGTCCATGCTGGCCC	0.617													11	23					4.93089e-13	5.03573e-13	1	1	0
WDR65	149465	broad.mit.edu	37	1	43675545	43675545	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:43675545G>C	uc001cip.1	+	11	2008	c.1887G>C	c.(1885-1887)AAG>AAC	p.K629N	EBNA1BP2_uc001cio.2_Intron|WDR65_uc010ojz.1_Missense_Mutation_p.K618N|WDR65_uc001ciq.1_Missense_Mutation_p.K629N	NM_152498	NP_689711	Q96MR6	WDR65_HUMAN	WD repeat domain 65	629										skin(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTCTGCAGAAGGAATTCAATG	0.577													21	57					0	0	1	0	0
KLF17	128209	broad.mit.edu	37	1	44595193	44595193	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:44595193G>A	uc001clp.2	+	2	308	c.250G>A	c.(250-252)GAA>AAA	p.E84K	KLF17_uc009vxf.1_Missense_Mutation_p.E47K	NM_173484	NP_775755	Q5JT82	KLF17_HUMAN	zinc finger protein 393	84					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					GAATGTGAATGAAGGGGGGCC	0.557													43	42					0	0	1	0	0
ATPAF1	64756	broad.mit.edu	37	1	47108892	47108892	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:47108892T>C	uc001cqh.2	-	8	871	c.766A>G	c.(766-768)ACT>GCT	p.T256A	ATPAF1_uc001cqg.2_Intron|ATPAF1_uc009vyk.2_Missense_Mutation_p.T105A|ATPAF1_uc010omg.1_Missense_Mutation_p.T168A|ATPAF1_uc001cqi.2_Intron	NM_022745	NP_073582	Q5TC12	ATPF1_HUMAN	ATP synthase mitochondrial F1 complex assembly	256					protein complex assembly	mitochondrion	protein binding				0	Acute lymphoblastic leukemia(166;0.155)					ATTTCTGCAGTCATCAGCACT	0.433													5	40					0	0	1	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52759346	52759346	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:52759346C>T	uc001cto.2	+	11	3419	c.3247C>T	c.(3247-3249)CGA>TGA	p.R1083*	ZFYVE9_uc001ctp.2_Nonsense_Mutation_p.R1024*	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	1083					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						AGCTGAATATCGACGTAAGTA	0.388													27	25					0	0	1	0	0
FAM159A	348378	broad.mit.edu	37	1	53122568	53122568	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:53122568G>A	uc001cuf.2	+	3	529	c.429G>A	c.(427-429)CAG>CAA	p.Q143Q	FAM159A_uc001cug.1_Intron|FAM159A_uc001cuh.2_Intron	NM_001042693	NP_001036158	Q6UWV7	F159A_HUMAN	hypothetical protein LOC348378	143						integral to membrane					0						TGAACCCGCAGCTGGAGAGCA	0.572													43	84					0	0	1	0	0
GLIS1	148979	broad.mit.edu	37	1	53980363	53980363	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:53980363C>T	uc001cvr.1	-	7	1860	c.1293G>A	c.(1291-1293)CTG>CTA	p.L431L		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	431					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						TGGTGGCATCCAGCGGGTGGT	0.642													51	75					0	0	1	0	0
DIO1	1733	broad.mit.edu	37	1	54360058	54360058	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:54360058G>A	uc010onx.1	+	1	198	c.175G>A	c.(175-177)GAC>AAC	p.D59N	DIO1_uc010onw.1_Intron|DIO1_uc009vzl.2_Missense_Mutation_p.D59N|DIO1_uc001cwb.2_Missense_Mutation_p.D59N|DIO1_uc010ony.1_Missense_Mutation_p.D59N|DIO1_uc001cwd.2_Intron|DIO1_uc001cwe.2_Intron|DIO1_uc001cwf.2_RNA|DIO1_uc001cwg.2_RNA	NM_000792	NP_000783	P49895	IOD1_HUMAN	deiodinase, iodothyronine, type I isoform a	59					hormone biosynthetic process|thyroid hormone generation	endoplasmic reticulum membrane|integral to membrane|plasma membrane	selenium binding|thyroxine 5'-deiodinase activity				0						TTTCAGCCACGACAACTGGAT	0.532													103	115					0	0	1	0	0
PRKAA2	5563	broad.mit.edu	37	1	57171796	57171796	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:57171796G>A	uc001cyk.3	+	8	1396	c.1325G>A	c.(1324-1326)AGA>AAA	p.R442K		NM_006252	NP_006243	P54646	AAPK2_HUMAN	AMP-activated protein kinase alpha 2 catalytic	442					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(4)|ovary(1)|stomach(1)	6						CGTGTAAGAAGAAAAAATCCA	0.308													16	39					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57233561	57233561	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:57233561G>A	uc001cym.3	-	5	1410	c.1004C>T	c.(1003-1005)TCA>TTA	p.S335L	C1orf168_uc009vzu.1_RNA	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	335										ovary(3)|skin(2)	5						TCTCAGATATGAAATTGTTGC	0.353													31	75					0	0	1	0	0
EFCAB7	84455	broad.mit.edu	37	1	64033988	64033988	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:64033988C>T	uc001dbf.2	+	12	1799	c.1505C>T	c.(1504-1506)CCA>CTA	p.P502L		NM_032437	NP_115813	A8K855	EFCB7_HUMAN	EF-hand calcium binding domain 7	502							calcium ion binding				0						CAGGCATGTCCATTTGTCATT	0.313													5	9					0	0	1	0	0
PGM1	5236	broad.mit.edu	37	1	64095131	64095131	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:64095131C>T	uc001dbh.2	+	2	495	c.282C>T	c.(280-282)CTC>CTT	p.L94L	PGM1_uc010ooy.1_5'UTR|PGM1_uc010ooz.1_Silent_p.L112L	NM_002633	NP_002624	P36871	PGM1_HUMAN	phosphoglucomutase 1	94					cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			ovary(2)|kidney(1)	3						ATGGAATCCTCTCCACCCCTG	0.473													116	68					0	0	1	0	0
LEPR	3953	broad.mit.edu	37	1	66067186	66067186	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:66067186G>A	uc001dci.2	+	9	1308	c.1106G>A	c.(1105-1107)TGG>TAG	p.W369*	LEPR_uc001dcg.2_Nonsense_Mutation_p.W369*|LEPR_uc001dch.2_Nonsense_Mutation_p.W369*|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Nonsense_Mutation_p.W369*|LEPR_uc001dck.2_Nonsense_Mutation_p.W369*	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	369	Extracellular (Potential).|Ig-like.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		ATTGTTTGGTGGATGAATTTA	0.353													16	61					0	0	1	0	0
TNNI3K	51086	broad.mit.edu	37	1	74701788	74701788	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:74701788G>A	uc001dgf.1	+	2	94	c.43G>A	c.(43-45)GAA>AAA	p.E15K	TNNI3K_uc001dgc.1_Missense_Mutation_p.E116K|TNNI3K_uc001dgd.2_Missense_Mutation_p.E116K|TNNI3K_uc001dge.1_Missense_Mutation_p.E116K	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	15						cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						TTTACTAGATGAATGGAAGAA	0.299													5	16					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75078435	75078435	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:75078435G>A	uc001dgg.2	-	9	1278	c.1059C>T	c.(1057-1059)TTC>TTT	p.F353F	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Silent_p.F147F	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	353										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TCCCATTCAGGAAAAAGGTGA	0.423													11	29					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75086477	75086477	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:75086477T>A	uc001dgg.2	-	8	1160	c.941A>T	c.(940-942)TAT>TTT	p.Y314F	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Missense_Mutation_p.Y108F	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	314										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GTGCTGCTGATAAACTTTAAT	0.363													31	33					0	0	1	0	0
RPF1	80135	broad.mit.edu	37	1	84961718	84961718	+	Silent	SNP	C	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:84961718C>A	uc001djv.3	+	7	898	c.853C>A	c.(853-855)CGG>AGG	p.R285R		NM_025065	NP_079341	Q9H9Y2	RPF1_HUMAN	RNA processing factor 1	285	Brix.				rRNA processing|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|rRNA binding				0						CCACAATCAACGGGATTACAT	0.363													18	61					1.9806e-07	2.00361e-07	1	1	0
CLCA4	22802	broad.mit.edu	37	1	87041138	87041138	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:87041138G>A	uc009wcs.2	+	11	1851	c.1807G>A	c.(1807-1809)GAC>AAC	p.D603N	CLCA4_uc009wct.2_Missense_Mutation_p.D366N|CLCA4_uc009wcu.2_Missense_Mutation_p.D423N	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	603						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		AATGAATAAGGACGTAAACAG	0.403													29	27					0	0	1	0	0
EVI5	7813	broad.mit.edu	37	1	93091480	93091480	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:93091480G>A	uc001dox.2	-	13	1501	c.1491C>T	c.(1489-1491)TCC>TCT	p.S497S	EVI5_uc010otf.1_Silent_p.S508S|EVI5_uc001doy.1_RNA	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	497	Targeting to the centrosomes.|Potential.|Dimerization.|Interaction with AURKB and INCENP.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		CATCAGGAAGGGAGTTATTCC	0.343													8	20					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94645431	94645431	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:94645431T>C	uc001dqj.3	-	20	2699	c.2330A>G	c.(2329-2331)CAA>CGA	p.Q777R	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dqk.2_Missense_Mutation_p.Q343R	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	777	Rho-GAP.				Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TTTTGTCTCTTGTTCTTCATT	0.299													20	54					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94697158	94697158	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:94697158G>A	uc001dqj.3	-	2	379	c.10C>T	c.(10-12)CAC>TAC	p.H4Y	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dql.2_Missense_Mutation_p.H4Y	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	4					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TTCTGTTTGTGAGCAATCATC	0.383													17	58					0	0	1	0	0
PALMD	54873	broad.mit.edu	37	1	100154844	100154844	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:100154844C>T	uc001dsg.2	+	7	1471	c.1028C>T	c.(1027-1029)CCG>CTG	p.P343L	PALMD_uc001dsf.2_Missense_Mutation_p.P343L	NM_017734	NP_060204	Q9NP74	PALMD_HUMAN	palmdelphin	343					regulation of cell shape	cytoplasm|membrane				ovary(2)|pancreas(1)	3		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		CTTCACACCCCGCAAAAAAGG	0.488													17	26					0	0	1	0	0
OLFM3	118427	broad.mit.edu	37	1	102271687	102271687	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:102271687C>T	uc001duf.2	-	5	775	c.704G>A	c.(703-705)GGA>GAA	p.G235E	OLFM3_uc001dug.2_Missense_Mutation_p.G215E|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_Missense_Mutation_p.G140E|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	235	Olfactomedin-like.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		AAATCGGGTTCCAGATGTCTT	0.423													24	48					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103400111	103400111	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:103400111C>T	uc001dul.2	-	46	3812	c.3494G>A	c.(3493-3495)GGA>GAA	p.G1165E	COL11A1_uc001duk.2_Missense_Mutation_p.G361E|COL11A1_uc001dum.2_Missense_Mutation_p.G1177E|COL11A1_uc001dun.2_Missense_Mutation_p.G1126E|COL11A1_uc009weh.2_Missense_Mutation_p.G1049E	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1165	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ACCATCACCTCCCTAGAGAAG	0.433													35	29					0	0	1	0	0
AMPD2	271	broad.mit.edu	37	1	110168821	110168821	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:110168821C>T	uc009wfh.1	+	5	1097	c.555C>T	c.(553-555)TTC>TTT	p.F185F	AMPD2_uc009wfg.1_RNA|AMPD2_uc001dyb.1_Silent_p.F104F|AMPD2_uc001dyc.1_Silent_p.F185F|AMPD2_uc010ovr.1_Silent_p.F110F|AMPD2_uc010ovs.1_Silent_p.F67F|AMPD2_uc001dyd.1_Silent_p.F66F	NM_004037	NP_004028	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2 (isoform L)	185					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|breast(1)	3		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		AGCAAGATTTCCTGAAGACGG	0.627													21	49					0	0	1	0	0
GSTM5	2949	broad.mit.edu	37	1	110259984	110259984	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:110259984T>C	uc001dyn.2	+	8	664	c.593T>C	c.(592-594)ATG>ACG	p.M198T	GSTM5_uc010ovu.1_3'UTR	NM_000851	NP_000842	P46439	GSTM5_HUMAN	glutathione S-transferase mu 5	198	GST C-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity			central_nervous_system(6)	6		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Colorectal(144;0.0131)|all cancers(265;0.0252)|Epithelial(280;0.0265)|Lung(183;0.0425)|COAD - Colon adenocarcinoma(174;0.0474)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	TCTGCCTACATGAAGTCCAGC	0.542													5	168					0	0	1	0	0
SLC6A17	388662	broad.mit.edu	37	1	110735143	110735144	+	Silent	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:110735143_110735144CC>TT	uc009wfq.2	+	8	1583_1584	c.1122_1123CC>TT	c.(1120-1125)ATCCTA>ATTTTA	p.374_375IL>IL	SLC6A17_uc001dze.1_5'UTR	NM_001010898	NP_001010898	Q9H1V8	S6A17_HUMAN	solute carrier family 6, member 17	374_375	Extracellular (Potential).				alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			ovary(1)|pancreas(1)	2		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		CTGAGAAAATCCTAGGGTACCT	0.554													15	72					0	0	1	0	0
KCNA10	3744	broad.mit.edu	37	1	111060109	111060109	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:111060109C>T	uc001dzt.1	-	1	1689	c.1301G>A	c.(1300-1302)GGG>GAG	p.G434E		NM_005549	NP_005540	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related	434						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			ovary(3)|large_intestine(1)	4		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		CACAATCTTCCCCCCTGGGGT	0.562													27	13					0	0	1	0	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	C	C	rs11554290		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:115256529T>C	uc009wgu.2	-	3	436	c.182A>G	c.(181-183)CAA>CGA	p.Q61R		NM_002524	NP_002515	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61	GTP.		Q -> K (in neuroblastoma cell).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(757)|p.Q61K(537)|p.Q61L(147)|p.Q61H(95)|p.Q61P(21)|p.Q61E(9)|p.Q61?(4)|p.Q61Q(3)|p.Q61_E62>HK(1)		haematopoietic_and_lymphoid_tissue(1008)|skin(956)|thyroid(334)|large_intestine(62)|NS(60)|soft_tissue(32)|lung(31)|upper_aerodigestive_tract(25)|urinary_tract(12)|liver(10)|adrenal_gland(9)|autonomic_ganglia(8)|testis(8)|central_nervous_system(8)|prostate(8)|breast(7)|biliary_tract(6)|ovary(6)|stomach(5)|pancreas(5)|endometrium(2)|kidney(2)|cervix(2)|eye(1)	2607	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458	Q61L(HEPG2_LIVER)|Q61R(SKMEL2_SKIN)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MHHES1_BONE)|Q61R(HT1197_URINARY_TRACT)|Q61L(MELJUSO_SKIN)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(KU1919_URINARY_TRACT)|Q61L(C3A_LIVER)|Q61R(TT2609C02_THYROID)|Q61R(NCIH2347_LUNG)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(SW1271_LUNG)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	50	Mis		melanoma|MM|AML|thyroid				Noonan_syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			145	97					0	0	1	0	0
CSDE1	7812	broad.mit.edu	37	1	115266543	115266543	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:115266543G>A	uc001efk.2	-	16	2300	c.1834C>T	c.(1834-1836)CAG>TAG	p.Q612*	CSDE1_uc001efi.2_Nonsense_Mutation_p.Q658*|CSDE1_uc001efj.2_RNA|CSDE1_uc001efl.2_Nonsense_Mutation_p.Q581*|CSDE1_uc001efm.2_Nonsense_Mutation_p.Q627*|CSDE1_uc009wgv.2_Nonsense_Mutation_p.Q612*|CSDE1_uc001efn.2_Nonsense_Mutation_p.Q581*	NM_001007553	NP_001007554	O75534	CSDE1_HUMAN	upstream of NRAS isoform 1	612	CSD 8.				male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TACTCAGTCTGTGTTGGATCA	0.438													175	163					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115466111	115466111	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:115466111G>A	uc001efr.2	+	21	1969	c.1760G>A	c.(1759-1761)AGA>AAA	p.R587K	SYCP1_uc010owt.1_RNA|SYCP1_uc001efq.2_Missense_Mutation_p.R587K|SYCP1_uc009wgw.2_Missense_Mutation_p.R587K	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	587	Potential.				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAACAGAAAAGAGATGAAGTT	0.224													4	5					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115523956	115523956	+	Splice_Site	SNP	G	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:115523956G>T	uc001efr.2	+	29	2592	c.2383_splice	c.e29-1	p.K795_splice	SYCP1_uc010owt.1_Splice_Site|SYCP1_uc001efq.2_Splice_Site_p.K795_splice|SYCP1_uc009wgw.2_Splice_Site_p.K770_splice	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1						cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTTCAATGCAGAAAACACAAA	0.289													4	12					0.014758	0.0147898	1	1	0
C1orf161	126868	broad.mit.edu	37	1	116675774	116675774	+	Missense_Mutation	SNP	G	A	A	rs150571972		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:116675774G>A	uc001egc.1	+	7	1142	c.877G>A	c.(877-879)GAG>AAG	p.E293K		NM_152367	NP_689580	Q8N8X9	MB213_HUMAN	hypothetical protein LOC126868	293											0	Lung SC(450;0.184)	all_cancers(81;0.00142)|all_lung(203;0.000139)|all_epithelial(167;0.000401)|Lung NSC(69;0.000705)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TTGGACCTGCGAGAAATATCC	0.478													11	25					0	0	1	0	0
MAN1A2	10905	broad.mit.edu	37	1	117944839	117944839	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:117944839C>T	uc001ehd.1	+	2	1055	c.334C>T	c.(334-336)CGA>TGA	p.R112*	MAN1A2_uc009whg.1_Intron	NM_006699	NP_006690	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	112	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity				0	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		AAATAAAATTCGAGCTGATCA	0.348													20	28					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118537122	118537122	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:118537122G>A	uc001ehk.2	-	35	5153	c.5085C>T	c.(5083-5085)TTC>TTT	p.F1695F		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1695						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		ATGCTTCATGGAAAGGGCGAA	0.428													14	26					0	0	1	0	0
HSD3B1	3283	broad.mit.edu	37	1	120056926	120056926	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:120056926G>A	uc001ehv.1	+	4	925	c.780G>A	c.(778-780)ACG>ACA	p.T260T	HSD3B1_uc001ehw.2_Silent_p.T262T	NM_000862	NP_000853	P14060	3BHS1_HUMAN	3 beta-hydroxysteroid dehydrogenase 1	260					androgen biosynthetic process|estrogen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.219)	all_lung(203;3.16e-06)|Lung NSC(69;2.19e-05)|all_epithelial(167;0.000624)		Lung(183;0.0106)|LUSC - Lung squamous cell carcinoma(189;0.0554)	NADH(DB00157)|Trilostane(DB01108)	CAGATGACACGCCTCACCAAA	0.522													50	35					0	0	1	0	0
PEX11B	8799	broad.mit.edu	37	1	145522864	145522864	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:145522864C>T	uc001eny.1	+	4	743	c.725C>T	c.(724-726)TCC>TTC	p.S242F	NBPF10_uc001emp.3_Intron|PEX11B_uc010oyu.1_Missense_Mutation_p.S228F|ITGA10_uc001enz.1_5'Flank|ITGA10_uc001eoa.2_5'Flank|ITGA10_uc010oyv.1_5'Flank|ITGA10_uc009wiw.2_5'Flank	NM_003846	NP_003837	O96011	PX11B_HUMAN	peroxisomal biogenesis factor 11 beta	242	Helical; (Potential).|Interaction with PEX19 and peroxisome targeting.				peroxisome fission|signal transduction	integral to peroxisomal membrane	protein binding				0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GGCCTCGTGTCCTCCATCCTG	0.542													62	52					0	0	1	0	0
BOLA1	51027	broad.mit.edu	37	1	149871954	149871954	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:149871954G>A	uc001etf.2	+	2	463	c.342G>A	c.(340-342)TGG>TGA	p.W114*		NM_016074	NP_057158	Q9Y3E2	BOLA1_HUMAN	bolA-like 1	114						extracellular region	protein binding			ovary(1)	1	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			CCGCCCAGTGGAGAGAGAACT	0.657													24	50					0	0	1	0	0
CGN	57530	broad.mit.edu	37	1	151491323	151491323	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:151491323G>A	uc009wmw.2	+	2	472	c.328G>A	c.(328-330)GGA>AGA	p.G110R		NM_020770	NP_065821	Q9P2M7	CING_HUMAN	cingulin	104	Head.					myosin complex|tight junction	actin binding|motor activity			ovary(2)|pancreas(1)	3	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			TCAGGTCAAGGGATTTCCTGC	0.587													12	7					0	0	1	0	0
RORC	6097	broad.mit.edu	37	1	151785505	151785505	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:151785505A>T	uc001ezh.2	-	9	1311	c.1203T>A	c.(1201-1203)TTT>TTA	p.F401L	RORC_uc001ezg.2_Missense_Mutation_p.F380L|RORC_uc010pdo.1_Missense_Mutation_p.F455L|RORC_uc010pdp.1_Missense_Mutation_p.F389L	NM_005060	NP_005051	P51449	RORG_HUMAN	RAR-related orphan receptor C isoform a	401	Ligand-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GGGAGAAGTCAAAGATGGAGC	0.537													35	50					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152084702	152084702	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:152084702G>C	uc001ezp.2	-	2	991	c.991C>G	c.(991-993)CAG>GAG	p.Q331E	TCHH_uc009wne.1_Missense_Mutation_p.Q331E	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	331	5 X 13 AA tandem repeats of R-R-E-Q-E-E- E-R-R-E-Q-Q-L.|1-2; approximate.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ctctcctcctgctgctcgcgc	0													3	67					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152277838	152277838	+	Missense_Mutation	SNP	G	A	A	rs139489857		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:152277838G>A	uc001ezu.1	-	3	9560	c.9524C>T	c.(9523-9525)TCC>TTC	p.S3175F		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3175	Filaggrin 19.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGAGTGCCTGGAGCTGTCTCC	0.552									Ichthyosis				330	247					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152280073	152280073	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:152280073C>T	uc001ezu.1	-	3	7325	c.7289G>A	c.(7288-7290)CGG>CAG	p.R2430Q		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2430	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGTCCCGGTCCGTCCATGGGC	0.587									Ichthyosis				115	273					0	0	1	0	0
LCE3D	84648	broad.mit.edu	37	1	152552221	152552221	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:152552221C>T	uc001fab.2	-	2	249	c.192G>A	c.(190-192)CGG>CGA	p.R64R		NM_032563	NP_115952	Q9BYE3	LCE3D_HUMAN	late cornified envelope 3D	64					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)|KIRC - Kidney renal clear cell carcinoma(4;0.0323)|Kidney(5;0.0378)		GCCTCTGGCGCCGGCATCGGT	0.682													30	56					0	0	1	0	0
LCE1F	353137	broad.mit.edu	37	1	152749155	152749155	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:152749155C>T	uc010pdv.1	+	1	308	c.308C>T	c.(307-309)TCC>TTC	p.S103F		NM_178354	NP_848131	Q5T754	LCE1F_HUMAN	late cornified envelope 1F	103					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCAGCGGGCTCCAGCTGCTGC	0.642													36	41					0	0	1	0	0
GATAD2B	57459	broad.mit.edu	37	1	153800618	153800618	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:153800618C>A	uc001fdb.3	-	2	450	c.206G>T	c.(205-207)GGC>GTC	p.G69V		NM_020699	NP_065750	Q8WXI9	P66B_HUMAN	GATA zinc finger domain containing 2B	69						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_lung(78;1.34e-32)|Lung NSC(65;1.04e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GACACCACTGCCATCCTGTTT	0.478													10	138					1.5842e-08	1.60494e-08	1	1	0
DENND4B	9909	broad.mit.edu	37	1	153914354	153914354	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:153914354G>A	uc001fdd.1	-	6	1447	c.1046C>T	c.(1045-1047)CCC>CTC	p.P349L		NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	349	DENN.									ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CGCTTCCAAGGGTAGGCGGTG	0.632													38	71					0	0	1	0	0
ATP8B2	57198	broad.mit.edu	37	1	154315361	154315361	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:154315361C>T	uc001fex.2	+	15	1476	c.1476C>T	c.(1474-1476)ATC>ATT	p.I492I		NM_020452	NP_065185	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform a	478	Cytoplasmic (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CTGTCAAGATCGGGGACCCCC	0.542													25	23					0	0	1	0	0
ZBTB7B	51043	broad.mit.edu	37	1	154987431	154987431	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:154987431C>A	uc001fgk.3	+	3	453	c.295C>A	c.(295-297)CTA>ATA	p.L99I	ZBTB7B_uc009wpa.2_Missense_Mutation_p.L99I|ZBTB7B_uc001fgj.3_Missense_Mutation_p.L133I|ZBTB7B_uc010peq.1_Missense_Mutation_p.L133I|ZBTB7B_uc001fgl.3_Missense_Mutation_p.L99I	NM_015872	NP_056956	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	99	BTB.				cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCCAGAGGCACTAGGCGCCCT	0.672													18	16					2.4624e-09	2.49827e-09	1	1	0
ADAM15	8751	broad.mit.edu	37	1	155029730	155029730	+	Silent	SNP	A	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:155029730A>C	uc001fgr.1	+	12	1316	c.1215A>C	c.(1213-1215)GGA>GGC	p.G405G	ADAM15_uc001fgq.1_Silent_p.G90G|ADAM15_uc010pet.1_Silent_p.G389G|ADAM15_uc010peu.1_Silent_p.G422G|ADAM15_uc001fgt.1_Silent_p.G405G|ADAM15_uc010pev.1_Silent_p.G415G|ADAM15_uc001fgs.1_Silent_p.G405G|ADAM15_uc001fgu.1_Silent_p.G405G|ADAM15_uc001fgw.1_Silent_p.G405G|ADAM15_uc001fgv.1_Silent_p.G405G|ADAM15_uc001fgx.1_Silent_p.G405G|ADAM15_uc001fgz.1_RNA|ADAM15_uc001fgy.1_RNA|ADAM15_uc001fha.1_RNA|ADAM15_uc001fhb.1_5'Flank	NM_207197	NP_997080	Q13444	ADA15_HUMAN	a disintegrin and metalloproteinase domain 15	405	Peptidase M12B.|Extracellular (Potential).				angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding	p.G405E(1)		central_nervous_system(3)|skin(2)|ovary(1)	6	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			TCCTGGATGGAATGGGCAGCT	0.617													36	29					0	0	1	0	0
CLK2	1196	broad.mit.edu	37	1	155239418	155239418	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:155239418C>A	uc001fjy.2	-	3	550	c.260G>T	c.(259-261)GGA>GTA	p.G87V	RAG1AP1_uc010pey.1_Intron|CLK2_uc001fjw.2_Missense_Mutation_p.G87V|CLK2_uc001fjx.2_5'UTR|CLK2_uc009wqm.2_Missense_Mutation_p.G87V	NM_003993	NP_003984	P49760	CLK2_HUMAN	CDC-like kinase 2	87						nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GTAGGCATCTCCCCGATCCCG	0.547								Other_conserved_DNA_damage_response_genes					204	192					1.8298e-113	1.89088e-113	1	1	0
ARHGEF2	9181	broad.mit.edu	37	1	155920117	155920117	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:155920117G>A	uc001fmt.2	-	21	2978	c.2860C>T	c.(2860-2862)CGT>TGT	p.R954C	ARHGEF2_uc001fmq.2_Missense_Mutation_p.R192C|ARHGEF2_uc001fmr.2_Missense_Mutation_p.R926C|ARHGEF2_uc001fms.2_Missense_Mutation_p.R953C|ARHGEF2_uc001fmu.2_Missense_Mutation_p.R998C	NM_001162383	NP_001155855	Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor 2	954					actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			ovary(1)	1	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					GGAGACAGACGGCTGCTACCT	0.622													45	128					0	0	1	0	0
SLC25A44	9673	broad.mit.edu	37	1	156180108	156180108	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:156180108C>T	uc001fnp.2	+	4	1153	c.831C>T	c.(829-831)GGC>GGT	p.G277G	SLC25A44_uc010phc.1_Silent_p.G168G|SLC25A44_uc009wrr.2_Silent_p.G285G|SLC25A44_uc010phd.1_RNA|SLC25A44_uc010phe.1_RNA|PMF1_uc009wru.1_5'Flank|PMF1_uc001fnq.2_5'Flank|PMF1_uc001fnr.2_5'Flank|BGLAP_uc001fns.1_5'Flank	NM_014655	NP_055470	Q96H78	S2544_HUMAN	solute carrier family 25, member 44	277	Solcar 3.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			ovary(1)	1	Hepatocellular(266;0.158)					TCATGAAGGGCCTCTCGGCCA	0.547													37	17					0	0	1	0	0
IQGAP3	128239	broad.mit.edu	37	1	156504330	156504330	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:156504330G>A	uc001fpf.2	-	29	3778	c.3703C>T	c.(3703-3705)CTG>TTG	p.L1235L		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1235					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TAGTCATTCAGGACCCGTAGG	0.602													25	4					0	0	1	0	0
TTC24	164118	broad.mit.edu	37	1	156552955	156552955	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:156552955G>A	uc009wsc.1	+	2	332	c.192G>A	c.(190-192)CGG>CGA	p.R64R		NM_001105669	NP_001099139	A2A3L6	TTC24_HUMAN	tetratricopeptide repeat domain 24	344	TPR 7.						binding			pancreas(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AGGCTGCCCGGGACTCTGGTA	0.647													55	46					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157497674	157497674	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:157497674G>A	uc001fqu.2	-	9	1851	c.1693C>T	c.(1693-1695)CGC>TGC	p.R565C	FCRL5_uc009wsm.2_Missense_Mutation_p.R565C|FCRL5_uc010phv.1_Missense_Mutation_p.R565C|FCRL5_uc010phw.1_Missense_Mutation_p.R480C	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	565	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity	p.R565H(1)		ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				AGGATGGGGCGAGACACTGGA	0.453													21	69					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157516958	157516958	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:157516958G>T	uc001fqu.2	-	3	240	c.82C>A	c.(82-84)CAG>AAG	p.Q28K	FCRL5_uc009wsm.2_Missense_Mutation_p.Q28K|FCRL5_uc010phv.1_Missense_Mutation_p.Q28K|FCRL5_uc010phw.1_Intron|FCRL5_uc001fqv.1_Missense_Mutation_p.Q28K|FCRL5_uc010phx.1_5'UTR	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	28	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				CATGGAGGCTGGAGGAAAATA	0.537													22	62					1.12875e-08	1.14436e-08	1	1	0
FCRL1	115350	broad.mit.edu	37	1	157766891	157766891	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:157766891C>T	uc001frg.2	-	10	1331	c.1218G>A	c.(1216-1218)AAG>AAA	p.K406K	FCRL1_uc001frf.2_RNA|FCRL1_uc001frh.2_Silent_p.K405K|FCRL1_uc001fri.2_Missense_Mutation_p.R364K|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	406	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			AGACTCTTACCTTGTCCTCCA	0.313													36	34					0	0	1	0	0
FCRL1	115350	broad.mit.edu	37	1	157768008	157768008	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:157768008C>T	uc001frg.2	-	8	1170	c.1057G>A	c.(1057-1059)GAG>AAG	p.E353K	FCRL1_uc001frf.2_RNA|FCRL1_uc001frh.2_Missense_Mutation_p.E353K|FCRL1_uc001fri.2_Missense_Mutation_p.E314K|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	353	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TAGGTGAACTCTTGGGGTAGA	0.493													3	48					0	0	1	0	0
AIM2	9447	broad.mit.edu	37	1	159033320	159033320	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:159033320C>T	uc001ftj.1	-	5	1206	c.961G>A	c.(961-963)GGA>AGA	p.G321R		NM_004833	NP_004824	O14862	AIM2_HUMAN	absent in melanoma 2	321	HIN-200.				cellular response to drug|immune response|interleukin-1 beta secretion	mitochondrion|nucleus				ovary(2)|pancreas(1)	3	all_hematologic(112;0.0429)					AGTTTTTCTCCATTTTTTGAC	0.413													13	138					0	0	1	0	0
SLAMF8	56833	broad.mit.edu	37	1	159803058	159803058	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:159803058G>A	uc001fue.3	+	4	890	c.680G>A	c.(679-681)GGG>GAG	p.G227E		NM_020125	NP_064510	Q9P0V8	SLAF8_HUMAN	SLAM family member 8 precursor	227	Extracellular (Potential).					integral to membrane					0	all_hematologic(112;0.0597)					TCAGCACCAGGGAAGGCCTCC	0.567													211	180					0	0	1	0	0
ATP1A4	480	broad.mit.edu	37	1	160146383	160146383	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:160146383G>A	uc001fve.3	+	17	3060	c.2581G>A	c.(2581-2583)GGA>AGA	p.G861R	ATP1A4_uc001fvf.3_Intron|ATP1A4_uc001fvg.2_Missense_Mutation_p.G364R|ATP1A4_uc001fvh.2_5'Flank	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	861	Helical; (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CATGGCCTATGGACAGATTGG	0.542													10	34					0	0	1	0	0
HSPA7	3311	broad.mit.edu	37	1	161576702	161576702	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:161576702G>A	uc010pkp.1	+	1	854	c.622G>A	c.(622-624)GAT>AAT	p.D208N		NR_024151				RecName: Full=Putative heat shock 70 kDa protein 7; AltName: Full=Heat shock 70 kDa protein B;												0						GGGCACCTTCGATGTGTCGGT	0.607													63	7					0	0	1	0	0
MYOC	4653	broad.mit.edu	37	1	171607827	171607827	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:171607827C>T	uc001ghu.2	-	2	662	c.640G>A	c.(640-642)GAA>AAA	p.E214K	MYOC_uc010pmk.1_Missense_Mutation_p.E156K	NM_000261	NP_000252	Q99972	MYOC_HUMAN	myocilin precursor	214					anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			lung(1)	1	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					GACTTCAGTTCCTGGAAGGCC	0.438													39	51					0	0	1	0	0
C1orf105	92346	broad.mit.edu	37	1	172434497	172434497	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:172434497C>T	uc001gik.2	+	6	596	c.400C>T	c.(400-402)CCA>TCA	p.P134S		NM_139240	NP_640333	O95561	CA105_HUMAN	hypothetical protein LOC92346	134										skin(1)	1						TGATGACATCCCAACAGGTTT	0.353													21	20					0	0	1	0	0
RC3H1	149041	broad.mit.edu	37	1	173933295	173933295	+	Silent	SNP	G	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:173933295G>C	uc001gju.3	-	10	1734	c.1647C>G	c.(1645-1647)GCC>GCG	p.A549A	RC3H1_uc010pms.1_Silent_p.A549A|RC3H1_uc001gjv.2_Silent_p.A549A|RC3H1_uc010pmt.1_Silent_p.A549A	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	549	Pro-rich.				cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						TCACAGGTAAGGCAGAAATAC	0.398													53	48					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564698	176564698	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:176564698G>A	uc001gkz.2	+	3	3122	c.1958G>A	c.(1957-1959)CGC>CAC	p.R653H	PAPPA2_uc001gky.1_Missense_Mutation_p.R653H|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	653	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GCTGATGTGCGCAAGACCTGC	0.527													7	51					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176640232	176640232	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:176640232G>C	uc001gkz.2	+	4	3282	c.2118G>C	c.(2116-2118)AAG>AAC	p.K706N	PAPPA2_uc001gky.1_Missense_Mutation_p.K706N|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	706	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CTTGGGACAAGGACGCTGTCA	0.493													10	21					0	0	1	0	0
FAM5B	57795	broad.mit.edu	37	1	177199087	177199087	+	Silent	SNP	G	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:177199087G>T	uc001glf.2	+	2	387	c.75G>T	c.(73-75)CTG>CTT	p.L25L		NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	25						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						TGCTGGCACTGGGCCTGCCTG	0.672													7	28					5.18039e-06	5.22541e-06	1	1	0
TDRD5	163589	broad.mit.edu	37	1	179561797	179561797	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:179561797G>A	uc001gnf.1	+	2	297	c.47G>A	c.(46-48)AGG>AAG	p.R16K	TDRD5_uc010pnp.1_Missense_Mutation_p.R16K|uc010pno.1_5'Flank	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	16	Lotus/OST-HTH 1.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						AAGGAAATAAGGTCACTTCTC	0.493													53	162					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	180022198	180022198	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:180022198C>T	uc001gnt.2	+	23	5269	c.4886C>T	c.(4885-4887)CCT>CTT	p.P1629L	CEP350_uc009wxl.2_Missense_Mutation_p.P1628L	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	1629						centrosome|nucleus|spindle				ovary(4)	4						TCATTACTACCTTCAGAGAGT	0.373													28	3					0	0	1	0	0
XPR1	9213	broad.mit.edu	37	1	180756945	180756945	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:180756945C>T	uc001goi.2	+	3	370	c.178C>T	c.(178-180)CAA>TAA	p.Q60*	XPR1_uc009wxm.2_Nonsense_Mutation_p.Q60*|XPR1_uc009wxn.2_Nonsense_Mutation_p.Q60*	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	60	SPX.|Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0						GAAGTTTTTCCAAACCTGTGA	0.343													55	44					0	0	1	0	0
RGL1	23179	broad.mit.edu	37	1	183852941	183852941	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:183852941C>T	uc001gqo.2	+	6	789	c.632C>T	c.(631-633)TCC>TTC	p.S211F	RGL1_uc010pof.1_Missense_Mutation_p.S16F|RGL1_uc001gqm.2_Missense_Mutation_p.S246F|RGL1_uc010pog.1_Missense_Mutation_p.S209F|RGL1_uc010poh.1_Missense_Mutation_p.S209F|RGL1_uc010poi.1_Missense_Mutation_p.S211F	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	211					cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						AACACGATCTCCTTCAGCCTG	0.463													13	52					0	0	1	0	0
FAM5C	339479	broad.mit.edu	37	1	190423889	190423889	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:190423889G>A	uc001gse.1	-	2	364	c.132C>T	c.(130-132)TTC>TTT	p.F44F	FAM5C_uc010pot.1_Missense_Mutation_p.S6L	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	44						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					GGAGCCAGTCGAAGGGGCTTG	0.498													28	28					0	0	1	0	0
CFHR1	3078	broad.mit.edu	37	1	196797325	196797325	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:196797325G>A	uc001gtn.2	+	4	670	c.556G>A	c.(556-558)GAA>AAA	p.E186K	CFHR1_uc001gtm.2_Missense_Mutation_p.E90K	NM_002113	NP_002104	Q03591	FHR1_HUMAN	complement factor H-related 1 precursor	186	Sushi 3.				complement activation	extracellular space					0						GTTTGGGGATGAAGAAGTGAT	0.378													42	109					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197396920	197396920	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:197396920G>A	uc001gtz.2	+	7	2600	c.2465G>A	c.(2464-2466)TGG>TAG	p.W822*	CRB1_uc010poz.1_Nonsense_Mutation_p.W753*|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Nonsense_Mutation_p.W710*|CRB1_uc010ppb.1_Intron|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Nonsense_Mutation_p.W303*|CRB1_uc001gub.1_Nonsense_Mutation_p.W471*	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	822	Extracellular (Potential).|Laminin G-like 2.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						GCTTCTACGTGGAAAATCGAA	0.373													18	4					0	0	1	0	0
C1orf106	55765	broad.mit.edu	37	1	200869306	200869306	+	Silent	SNP	C	T	T	rs34596202	byFrequency	TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:200869306C>T	uc001gvo.2	+	4	540	c.510C>T	c.(508-510)ATC>ATT	p.I170I	C1orf106_uc010ppm.1_Silent_p.I85I	NM_018265	NP_060735	Q3KP66	CA106_HUMAN	hypothetical protein LOC55765 isoform 1	170										skin(2)|ovary(1)	3						GCCGCAGGATCGGAGCGGCTT	0.607													31	27					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201009192	201009192	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:201009192G>T	uc001gvv.2	-	44	5616	c.5389C>A	c.(5389-5391)CTG>ATG	p.L1797M		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1797	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	AAGGTGCCCAGGCCCCCTCGA	0.602													28	66					3.6622e-26	3.76213e-26	1	1	0
NAV1	89796	broad.mit.edu	37	1	201779105	201779106	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:201779105_201779106CC>TT	uc001gwu.2	+	22	4771_4772	c.4424_4425CC>TT	c.(4423-4425)ACC>ATT	p.T1475I	NAV1_uc001gwx.2_Missense_Mutation_p.T1084I	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1478					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						CCAGCCTCTACCCTGGGACTAA	0.485													25	77					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203681256	203681256	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:203681256G>A	uc001gzw.2	+	13	3084	c.2200G>A	c.(2200-2202)GAG>AAG	p.E734K	ATP2B4_uc001gzv.2_Missense_Mutation_p.E734K|ATP2B4_uc009xaq.2_Missense_Mutation_p.E734K	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	734	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CATCCGCAACGAGAAAGGCGA	0.562													66	4					0	0	1	0	0
SOX13	9580	broad.mit.edu	37	1	204091518	204091518	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:204091518C>T	uc001ham.2	+	9	1610	c.1015C>T	c.(1015-1017)CTG>TTG	p.L339L	SOX13_uc010pqp.1_Silent_p.L338L|SOX13_uc010pqq.1_Silent_p.L206L	NM_005686	NP_005677	Q9UN79	SOX13_HUMAN	SRY-box 13	339	Pro-rich.				anatomical structure morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2	all_cancers(21;0.0754)|Breast(84;0.116)|all_epithelial(62;0.189)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)			CCCCCCGAGCCTGCCTCTGGG	0.582													8	0					0	0	1	0	0
C1orf186	440712	broad.mit.edu	37	1	206240150	206240150	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:206240150G>A	uc001hdt.1	-	5	941	c.302C>T	c.(301-303)TCG>TTG	p.S101L		NM_001007544	NP_001007545	Q6ZWK4	CA186_HUMAN	hypothetical protein LOC440712	101						integral to membrane					0			BRCA - Breast invasive adenocarcinoma(75;0.0754)			GGCAGGAGGCGAACTGCAGGA	0.512													172	19					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209823368	209823369	+	Nonsense_Mutation	DNP	GG	AA	AA	rs80356680		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:209823368_209823369GG>AA	uc001hhg.2	-	2	513_514	c.123_124CC>TT	c.(121-126)CTCCGA>CTTTGA	p.R42*	LAMB3_uc009xco.2_Nonsense_Mutation_p.R42*|LAMB3_uc001hhh.2_Nonsense_Mutation_p.R42*|LAMB3_uc010psl.1_RNA|LAMB3_uc009xcp.1_Nonsense_Mutation_p.R42*	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	42	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GATGAAGCTCGGAGAAACCGGG	0.614													19	84					0	0	1	0	0
TP53BP2	7159	broad.mit.edu	37	1	224008965	224008966	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:224008965_224008966GG>AA	uc010pvb.1	-	2	423_424	c.131_132CC>TT	c.(130-132)CCC>CTT	p.P44L	TP53BP2_uc001hod.2_5'UTR	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	38					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		CACTCTCGCCGGGTTCTTTGCA	0.465													85	7					0	0	1	0	0
NVL	4931	broad.mit.edu	37	1	224475510	224475510	+	Silent	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:224475510T>C	uc001hok.2	-	14	1804	c.1761A>G	c.(1759-1761)GAA>GAG	p.E587E	NVL_uc001hol.2_Silent_p.E481E|NVL_uc010pvd.1_Silent_p.E496E|NVL_uc010pve.1_Silent_p.E398E|NVL_uc010pvf.1_RNA	NM_002533	NP_002524	O15381	NVL_HUMAN	nuclear VCP-like isoform 1	587						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			skin(2)	2				GBM - Glioblastoma multiforme(131;0.00501)		CTCTAATGTCTTCCAGGGCAC	0.443													31	37					0	0	1	0	0
LIN9	286826	broad.mit.edu	37	1	226453309	226453309	+	Silent	SNP	C	T	T	rs144126698		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:226453309C>T	uc001hqa.2	-	10	1321	c.1011G>A	c.(1009-1011)TCG>TCA	p.S337S	LIN9_uc001hqb.2_Silent_p.S302S|LIN9_uc001hqc.2_Silent_p.S269S|LIN9_uc009xel.1_Silent_p.S302S	NM_173083	NP_775106	Q5TKA1	LIN9_HUMAN	lin-9 homolog	321					cell cycle|DNA replication	nucleoplasm					0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		TTCTCCACGGCGACTGTCCTA	0.313													12	48					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233122150	233122150	+	Silent	SNP	C	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:233122150C>A	uc001hvl.2	-	33	6163	c.5928G>T	c.(5926-5928)CTG>CTT	p.L1976L	PCNXL2_uc001hvk.1_Silent_p.L628L|PCNXL2_uc001hvm.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1976	Ser-rich.					integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				GCCTCTGGGCCAGCTCGTGCA	0.662													8	5					0.0581538	0.0582374	1	1	0
ARID4B	51742	broad.mit.edu	37	1	235345322	235345322	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:235345322G>A	uc001hwq.2	-	20	3410	c.2912C>T	c.(2911-2913)ACT>ATT	p.T971I	ARID4B_uc001hwr.2_Missense_Mutation_p.T885I|ARID4B_uc001hws.3_Missense_Mutation_p.T885I|ARID4B_uc001hwp.2_RNA|ARID4B_uc001hwt.3_Missense_Mutation_p.T652I	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	971					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			TTCAGCCACAGTCTGCAGTGA	0.498													135	12					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235969576	235969576	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:235969576G>A	uc001hxj.2	-	6	3035	c.2860C>T	c.(2860-2862)CCT>TCT	p.P954S	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Missense_Mutation_p.P954S	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	954					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			ATATGTTCAGGAGAAGGCAAG	0.448									Chediak-Higashi_syndrome				17	74					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235973733	235973733	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:235973733G>A	uc001hxj.2	-	5	560	c.385C>T	c.(385-387)CTG>TTG	p.L129L	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Silent_p.L129L	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	129					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TGACTAGACAGGGCACTTCCT	0.383									Chediak-Higashi_syndrome				39	26					0	0	1	0	0
WDR64	128025	broad.mit.edu	37	1	241929524	241929524	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:241929524C>T	uc001hzf.1	+	10	1235	c.1082C>T	c.(1081-1083)CCC>CTC	p.P361L	WDR64_uc001hzg.1_Missense_Mutation_p.P107L	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	641										skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			CTTCAGAATCCCACCATGGAT	0.363													24	26					0	0	1	0	0
OR2B11	127623	broad.mit.edu	37	1	247614950	247614950	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:247614950C>T	uc010pyx.1	-	1	335	c.335G>A	c.(334-336)GGA>GAA	p.G112E		NM_001004492	NP_001004492	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CTCCGTGCATCCCAGCCAGTG	0.592													43	33					0	0	1	0	0
OR2L2	26246	broad.mit.edu	37	1	248201627	248201627	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:248201627T>C	uc001idw.2	+	1	154	c.58T>C	c.(58-60)TCA>CCA	p.S20P	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GTTCCCACAATCAAGAATTGG	0.378													69	85					0	0	1	0	0
OR2M3	127062	broad.mit.edu	37	1	248366836	248366836	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:248366836G>A	uc010pzg.1	+	1	467	c.467G>A	c.(466-468)GGA>GAA	p.G156E		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TCTACGGATGGAATTATTGAT	0.463													68	65					0	0	1	0	0
OR2T3	343173	broad.mit.edu	37	1	248637323	248637323	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:248637323C>T	uc001iel.1	+	1	672	c.672C>T	c.(670-672)ACC>ACT	p.T224T		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	224	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCTCATACACCCTCATCCTGC	0.562													11	212					0	0	1	0	0
AKR1C4	1109	broad.mit.edu	37	10	5238831	5238831	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:5238831A>G	uc001ihw.2	+	1	34	c.1A>G	c.(1-3)ATG>GTG	p.M1V		NM_001818	NP_001809	P17516	AK1C4_HUMAN	aldo-keto reductase family 1, member C4	1					androgen metabolic process|bile acid biosynthetic process	cytosol	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (B-specific) activity|bile acid transmembrane transporter activity|chlordecone reductase activity|electron carrier activity			ovary(1)	1					NADH(DB00157)	GTGGCAAGCAATGGATCCCAA	0.443													40	58					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6540402	6540402	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:6540402G>A	uc001ijj.1	-	5	573	c.498C>T	c.(496-498)TTC>TTT	p.F166F	PRKCQ_uc009xim.1_Silent_p.F166F|PRKCQ_uc001iji.1_Silent_p.F199F|PRKCQ_uc009xin.1_Silent_p.F130F|PRKCQ_uc010qax.1_Silent_p.F41F	NM_006257	NP_006248	Q04759	KPCT_HUMAN	protein kinase C, theta	166	Phorbol-ester/DAG-type 1.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			ovary(3)|lung(2)|large_intestine(1)	6						GCTGTGGGAAGAAGGTGGCAG	0.522													48	82					0	0	1	0	0
SFMBT2	57713	broad.mit.edu	37	10	7409679	7409679	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:7409679A>G	uc009xio.1	-	4	459	c.368T>C	c.(367-369)GTA>GCA	p.V123A	SFMBT2_uc001ijn.1_Missense_Mutation_p.V123A|SFMBT2_uc010qay.1_Missense_Mutation_p.V123A|SFMBT2_uc001ijo.1_Missense_Mutation_p.V123A	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	123	MBT 1.				regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						CGCGATGACTACGTCACACCA	0.602													10	35					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7621770	7621770	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:7621770C>T	uc001ijq.2	-	9	1445	c.1366G>A	c.(1366-1368)GGC>AGC	p.G456S	ITIH5_uc001ijp.2_Missense_Mutation_p.G242S|ITIH5_uc001ijr.1_Missense_Mutation_p.G456S	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	456	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						CGTGTGAGGCCACAGTTCTCC	0.622													45	51					0	0	1	0	0
CACNB2	783	broad.mit.edu	37	10	18828327	18828327	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:18828327G>A	uc001ipr.2	+	14	1717	c.1657G>A	c.(1657-1659)GAG>AAG	p.E553K	CACNB2_uc009xjz.1_Missense_Mutation_p.E303K|CACNB2_uc001ips.2_Missense_Mutation_p.E529K|CACNB2_uc001ipt.2_Missense_Mutation_p.E515K|CACNB2_uc001ipu.2_Missense_Mutation_p.E525K|CACNB2_uc001ipv.2_Missense_Mutation_p.E501K|CACNB2_uc009xka.1_Missense_Mutation_p.E487K|CACNB2_uc001ipw.2_Missense_Mutation_p.E460K|CACNB2_uc001ipx.2_Missense_Mutation_p.E498K|CACNB2_uc001ipz.2_Missense_Mutation_p.E475K|CACNB2_uc001ipy.2_Missense_Mutation_p.E499K|CACNB2_uc010qco.1_Missense_Mutation_p.E467K|CACNB2_uc001iqa.2_Missense_Mutation_p.E505K|NSUN6_uc001iqb.2_Intron	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	553					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CTCCAGGCAAGAGACATTTGA	0.557													9	21					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21097533	21097533	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:21097533G>A	uc001iqi.2	-	26	3064	c.2667C>T	c.(2665-2667)TTC>TTT	p.F889F	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	889	Linker.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						GACCTGTACCGAAAGTACTGC	0.463													35	48					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25887683	25887683	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:25887683C>T	uc001isj.2	+	11	3188	c.3128C>T	c.(3127-3129)TCC>TTC	p.S1043F	GPR158_uc001isk.2_Missense_Mutation_p.S418F	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	1043	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						CCCACTTTTTCCTTAAAGGAG	0.453													16	9					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27702693	27702693	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:27702693C>T	uc001itu.2	-	1	605	c.487G>A	c.(487-489)GAA>AAA	p.E163K		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	163					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TCTTCCTCTTCGTCCTTGGGT	0.662													25	77					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37490190	37490190	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:37490190G>A	uc001iza.1	+	31	2737	c.2638G>A	c.(2638-2640)GAT>AAT	p.D880N		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	936						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						TTCACAGAAGGATGTGTGTGT	0.299													18	28					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37505199	37505199	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:37505199G>A	uc001iza.1	+	32	2891	c.2792G>A	c.(2791-2793)GGA>GAA	p.G931E		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	987						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CAACGTACAGGAAAAATGGAA	0.333													5	6					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508414	37508414	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:37508414G>A	uc001iza.1	+	34	3705	c.3606G>A	c.(3604-3606)AGG>AGA	p.R1202R		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1258						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						AAGCTCAAAGGAAATCCAAAA	0.368													3	5					0	0	1	0	0
RET	5979	broad.mit.edu	37	10	43614995	43614995	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:43614995C>T	uc001jal.2	+	14	2599	c.2409C>T	c.(2407-2409)ATC>ATT	p.I803I	RET_uc001jak.1_Silent_p.I803I|RET_uc010qez.1_Silent_p.I549I	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	803	Protein kinase.|Cytoplasmic (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	TCCTCCTCATCGTGGAGTACG	0.706		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				2	1					0	0	1	0	0
ZNF488	118738	broad.mit.edu	37	10	48371067	48371067	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:48371067G>A	uc001jex.2	+	2	697	c.535G>A	c.(535-537)GTC>ATC	p.V179I	ZNF488_uc001jey.2_Missense_Mutation_p.V72I	NM_153034	NP_694579	Q96MN9	ZN488_HUMAN	zinc finger protein 488	179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GCTAACCTCAGTCTTCCCTGC	0.562													24	26					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48381965	48381965	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:48381965C>T	uc001jez.2	-	4	3798	c.3684G>A	c.(3682-3684)GAG>GAA	p.E1228E		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	1228	4 X approximate tandem repeats.|4.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	GCTGGAGCATCTCCTTGGCCC	0.662													12	11					0	0	1	0	0
GDF2	2658	broad.mit.edu	37	10	48414000	48414001	+	Missense_Mutation	DNP	CC	GT	GT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:48414000_48414001CC>GT	uc001jfa.1	-	2	1030_1031	c.867_868GG>AC	c.(865-870)AAGGAC>AAACAC	p.D290H		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	290					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						GTGGAGCCGTCCTTGGACAGCT	0.609													13	26					0	0	1	0	0
GDF10	2662	broad.mit.edu	37	10	48429244	48429244	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:48429244G>A	uc001jfb.2	-	2	1098	c.642C>T	c.(640-642)CGC>CGT	p.R214R	GDF10_uc009xnp.2_Silent_p.R213R|GDF10_uc009xnq.1_Silent_p.R214R	NM_004962	NP_004953	P55107	BMP3B_HUMAN	growth differentiation factor 10 precursor	214					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			lung(1)|central_nervous_system(1)	2						CGCCATCCCGGCGGGCCGCCT	0.721													17	13					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49448490	49448490	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:49448490T>C	uc001jgi.2	-	6	720	c.613A>G	c.(613-615)AGA>GGA	p.R205G	FRMPD2_uc001jgh.2_Missense_Mutation_p.R174G|FRMPD2_uc001jgj.2_Missense_Mutation_p.R183G	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	205					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		AGGTAGCTTCTGTTCTGCTGC	0.582													4	36					0	0	1	0	0
PGBD3	267004	broad.mit.edu	37	10	50724156	50724156	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:50724156A>C	uc001jht.2	-	2	1260	c.1005T>G	c.(1003-1005)TTT>TTG	p.F335L	ERCC6_uc001jhs.3_Intron|PGBD3_uc009xoe.2_Missense_Mutation_p.F803L|PGBD3_uc001jhu.2_Missense_Mutation_p.F803L	NM_170753	NP_736609	Q8N328	PGBD3_HUMAN	hypothetical protein LOC267004	335										pancreas(1)|breast(1)|skin(1)	3						GTGCCTCACTAAACTGAAGGA	0.433													31	33					0	0	1	0	0
NCOA4	8031	broad.mit.edu	37	10	51582882	51582882	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:51582882A>G	uc001jis.3	+	7	860	c.657A>G	c.(655-657)ATA>ATG	p.I219M	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron|NCOA4_uc009xon.2_Missense_Mutation_p.I235M|NCOA4_uc010qhd.1_Missense_Mutation_p.I235M|NCOA4_uc010qhe.1_Missense_Mutation_p.I119M|NCOA4_uc010qhf.1_Missense_Mutation_p.I53M|NCOA4_uc001jit.2_Missense_Mutation_p.I219M|NCOA4_uc009xoo.2_Missense_Mutation_p.I219M	NM_001145263	NP_001138735	Q13772	NCOA4_HUMAN	nuclear receptor coactivator 4 isoform 3	219					androgen receptor signaling pathway|male gonad development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	androgen receptor binding|transcription coactivator activity			central_nervous_system(1)|kidney(1)	2						CTCCTTACATACCCAGCACCG	0.483			T	RET	papillary thyroid 								7	37					0	0	1	0	0
SGMS1	259230	broad.mit.edu	37	10	52067877	52067877	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:52067877C>T	uc001jje.2	-	10	1881	c.927G>A	c.(925-927)TGG>TGA	p.W309*	SGMS1_uc010qhk.1_Nonsense_Mutation_p.W140*	NM_147156	NP_671512	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	315	Helical; (Potential).				apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			ovary(1)|kidney(1)	2						GCCAGCAAATCCAGTGATACC	0.483													17	28					0	0	1	0	0
SLC16A9	220963	broad.mit.edu	37	10	61414206	61414206	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:61414206G>A	uc010qig.1	-	5	1027	c.578C>T	c.(577-579)TCT>TTT	p.S193F		NM_194298	NP_919274	Q7RTY1	MOT9_HUMAN	solute carrier family 16 (monocarboxylic acid	193	Extracellular (Potential).				urate metabolic process	integral to membrane|plasma membrane	symporter activity			skin(2)|ovary(1)	3						ACAATCAGAAGATTGGAGGGG	0.388													6	50					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	62023728	62023728	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:62023728G>A	uc001jky.2	-	6	756	c.564C>T	c.(562-564)GTC>GTT	p.V188V	ANK3_uc010qih.1_Silent_p.V171V|ANK3_uc001jkz.3_Silent_p.V182V|ANK3_uc001jlb.1_5'UTR	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	188	ANK 4.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GGAGCGAAACGACTTGGTCGT	0.507													9	21					0	0	1	0	0
JMJD1C	221037	broad.mit.edu	37	10	64973537	64973537	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:64973537G>A	uc001jmn.2	-	8	2690	c.2390C>T	c.(2389-2391)CCC>CTC	p.P797L	JMJD1C_uc001jml.2_Missense_Mutation_p.P578L|JMJD1C_uc001jmm.2_Missense_Mutation_p.P509L|JMJD1C_uc010qiq.1_Missense_Mutation_p.P615L|JMJD1C_uc009xpi.2_Missense_Mutation_p.P615L|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmp.1_Missense_Mutation_p.P509L	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	797					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					TAACACAGTGGGAAGTAAATG	0.507													13	17					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	69281676	69281676	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:69281676G>A	uc009xpn.1	-	5	626	c.503C>T	c.(502-504)TCT>TTT	p.S168F	CTNNA3_uc001jmw.2_Missense_Mutation_p.S168F|CTNNA3_uc001jmx.3_Missense_Mutation_p.S168F|CTNNA3_uc009xpo.1_Missense_Mutation_p.S28F|CTNNA3_uc001jna.2_Missense_Mutation_p.S180F	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	168					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						CTGGAGGTCAGATTTGTTGGC	0.393													21	32					0	0	1	0	0
MYPN	84665	broad.mit.edu	37	10	69934248	69934248	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:69934248C>T	uc001jnm.3	+	12	2584	c.2399C>T	c.(2398-2400)TCC>TTC	p.S800F	MYPN_uc001jnn.3_Missense_Mutation_p.S525F|MYPN_uc001jno.3_Missense_Mutation_p.S800F|MYPN_uc009xpt.2_Missense_Mutation_p.S800F|MYPN_uc010qit.1_Missense_Mutation_p.S506F|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	800	Pro-rich.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						TTCACATTTTCCATCCCCAGC	0.547													22	28					0	0	1	0	0
KIAA1274	27143	broad.mit.edu	37	10	72299398	72299398	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:72299398G>A	uc001jrd.3	+	15	2069	c.1788G>A	c.(1786-1788)CTG>CTA	p.L596L	KIAA1274_uc001jre.3_5'UTR	NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274	596										ovary(2)|central_nervous_system(1)	3						AGGGCCCCCTGACCTACAGGT	0.667													24	32					0	0	1	0	0
KIAA1274	27143	broad.mit.edu	37	10	72301249	72301249	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:72301249G>A	uc001jrd.3	+	17	2361	c.2080G>A	c.(2080-2082)GTG>ATG	p.V694M	KIAA1274_uc001jre.3_Translation_Start_Site	NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274	694										ovary(2)|central_nervous_system(1)	3						GGAGGAGCTCGTGAGTGTGCC	0.627													9	22					0	0	1	0	0
OIT3	170392	broad.mit.edu	37	10	74673068	74673068	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:74673068C>T	uc001jte.1	+	6	1011	c.793C>T	c.(793-795)CCT>TCT	p.P265S	OIT3_uc009xqs.1_RNA	NM_152635	NP_689848	Q8WWZ8	OIT3_HUMAN	oncoprotein-induced transcript 3 precursor	265	ZP.					nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)					CTCTGCAGTCCCTGTGTTGTG	0.507													65	69					0	0	1	0	0
ADK	132	broad.mit.edu	37	10	76468180	76468180	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:76468180C>T	uc001jwi.2	+	11	1138	c.1066C>T	c.(1066-1068)CCT>TCT	p.P356S	ADK_uc010qlb.1_Missense_Mutation_p.P299S|ADK_uc001jwj.2_Missense_Mutation_p.P339S|ADK_uc010qlc.1_Missense_Mutation_p.P321S|ADK_uc001jwl.2_Missense_Mutation_p.P126S	NM_006721	NP_006712	P55263	ADK_HUMAN	adenosine kinase isoform b	356					purine base metabolic process|purine ribonucleoside salvage	cytosol	adenosine kinase activity|ATP binding|metal ion binding|phosphotransferase activity, alcohol group as acceptor			ovary(1)|skin(1)	2	Prostate(51;0.0112)|Ovarian(15;0.148)				Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Pegademase bovine(DB00061)|Ribavirin(DB00811)	CTGCACCTTTCCTGAGAAGCC	0.473													13	18					0	0	1	0	0
DUPD1	338599	broad.mit.edu	37	10	76797614	76797614	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:76797614C>T	uc001jwq.1	-	3	643	c.643G>A	c.(643-645)GAG>AAG	p.E215K		NM_001003892	NP_001003892	Q68J44	DUPD1_HUMAN	dual specificity phosphatase and pro isomerase	215						cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)	2	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					CTGCCATCCTCCTCCTCACCG	0.652													40	60					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79589264	79589264	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:79589264G>A	uc001jzk.2	-	12	2104	c.2034C>T	c.(2032-2034)ATC>ATT	p.I678I	DLG5_uc001jzj.2_Silent_p.I433I|DLG5_uc009xru.1_RNA|DLG5_uc001jzl.3_Silent_p.I282I	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	678	PDZ 1.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CCACATCGTTGATTCTCAGCA	0.592													69	83					0	0	1	0	0
NRG3	10718	broad.mit.edu	37	10	84738844	84738844	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:84738844G>A	uc001kco.2	+	8	1578	c.1551G>A	c.(1549-1551)AGG>AGA	p.R517R	NRG3_uc010qlz.1_Silent_p.R516R|NRG3_uc001kcp.2_Silent_p.R296R|NRG3_uc001kcq.2_Silent_p.R167R|NRG3_uc001kcr.2_Silent_p.R167R	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	517	Cytoplasmic (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		AAGAATCAAGGATCCCAGACC	0.478													11	18					0	0	1	0	0
NRG3	10718	broad.mit.edu	37	10	84738857	84738857	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:84738857G>A	uc001kco.2	+	8	1591	c.1564G>A	c.(1564-1566)GAT>AAT	p.D522N	NRG3_uc010qlz.1_Missense_Mutation_p.D521N|NRG3_uc001kcp.2_Missense_Mutation_p.D301N|NRG3_uc001kcq.2_Missense_Mutation_p.D172N|NRG3_uc001kcr.2_Missense_Mutation_p.D172N	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	522	Cytoplasmic (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		CCCAGACCAGGATACGATACC	0.478													10	14					0	0	1	0	0
CDHR1	92211	broad.mit.edu	37	10	85970858	85970858	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:85970858C>T	uc001kcv.2	+	13	1422	c.1422C>T	c.(1420-1422)TCC>TCT	p.S474S	CDHR1_uc001kcw.2_Silent_p.S474S|CDHR1_uc009xst.2_Intron|CDHR1_uc001kcx.2_5'Flank	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	474	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						AGTTCGACTCCCTCTACTACG	0.582													50	66					0	0	1	0	0
LRIT1	26103	broad.mit.edu	37	10	85992034	85992034	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:85992034C>G	uc001kcz.1	-	4	1543	c.1521G>C	c.(1519-1521)AAG>AAC	p.K507N		NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL	507	Fibronectin type-III.|Lumenal (Potential).					integral to endoplasmic reticulum membrane					0						CACACTGCTCCTTCCGGGGCA	0.542													12	17					0	0	1	0	0
FAM190B	54462	broad.mit.edu	37	10	86131537	86131537	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:86131537C>T	uc001kdh.1	+	2	923	c.729C>T	c.(727-729)TCC>TCT	p.S243S	FAM190B_uc001kdg.1_Silent_p.S243S|FAM190B_uc010qmd.1_Silent_p.S243S	NM_018999	NP_061872	Q9H7U1	F190B_HUMAN	granule cell antiserum positive 14	243										ovary(3)|skin(1)	4						GATCACATTCCTTTAATAGAG	0.378													10	23					0	0	1	0	0
WAPAL	23063	broad.mit.edu	37	10	88206201	88206201	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:88206201G>A	uc001kdo.2	-	16	3562	c.3120C>T	c.(3118-3120)TTC>TTT	p.F1040F	WAPAL_uc009xsv.2_Silent_p.F299F|WAPAL_uc001kdn.2_Silent_p.F1077F|WAPAL_uc009xsw.2_Silent_p.F1034F	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	1040	WAPL.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						CTCGCTCAAGGAATAGCTGAT	0.368													5	13					0	0	1	0	0
SNCG	6623	broad.mit.edu	37	10	88718536	88718536	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:88718536G>A	uc001keb.2	+	1	249	c.82G>A	c.(82-84)GAA>AAA	p.E28K	MMRN2_uc001kea.2_5'Flank|MMRN2_uc010qmn.1_5'Flank|MMRN2_uc009xtb.2_5'Flank	NM_003087	NP_003078	O76070	SYUG_HUMAN	synuclein, gamma (breast cancer-specific protein	28	1.|4 X 11 AA tandem repeats of [EGSA]-K-T-K- [EQ]-[GQ]-V-X(4).					microtubule organizing center|perinuclear region of cytoplasm|spindle	protein binding				0						GGGGGTGACGGAAGCAGCTGA	0.592													35	34					0	0	1	0	0
ACTA2	59	broad.mit.edu	37	10	90697867	90697867	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:90697867C>T	uc001kfp.2	-	8	1057	c.941G>A	c.(940-942)CGA>CAA	p.R314Q	STAMBPL1_uc010qmx.1_Intron|ACTA2_uc010qmy.1_Missense_Mutation_p.R269Q|ACTA2_uc001kfq.2_Missense_Mutation_p.R314Q|uc001kfo.1_Intron	NM_001613	NP_001604	P62736	ACTA_HUMAN	alpha 2 actin	314					response to virus	cytosol	ATP binding				0		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)		CTTCTGCATTCGGTCGGCAAT	0.522													32	52					0	0	1	0	0
CYP26A1	1592	broad.mit.edu	37	10	94836975	94836975	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:94836975G>A	uc001kil.2	+	7	1453	c.1408G>A	c.(1408-1410)GGA>AGA	p.G470R	CYP26A1_uc001kik.1_Missense_Mutation_p.G401R|CYP26A1_uc001kim.1_Missense_Mutation_p.G368R	NM_000783	NP_000774	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A,	470					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		Colorectal(252;0.122)				GCTTCTAAATGGACCTCCTAC	0.453													24	43					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96702071	96702071	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:96702071C>T	uc001kka.3	+	3	479	c.454C>T	c.(454-456)CTT>TTT	p.L152F	CYP2C9_uc009xut.2_Missense_Mutation_p.L152F|CYP2C9_uc001kjz.2_Missense_Mutation_p.L152F	NM_000771	NP_000762	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C,	152					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(4)|ovary(2)	6		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	AGCCCGCTGCCTTGTGGAGGA	0.498													30	32					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96827385	96827385	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:96827385G>A	uc001kkb.2	-	2	327	c.232C>T	c.(232-234)CAT>TAT	p.H78Y	CYP2C8_uc001kkc.2_RNA|CYP2C8_uc010qoa.1_Missense_Mutation_p.H8Y|CYP2C8_uc010qob.1_5'UTR|CYP2C8_uc010qoc.1_Intron|CYP2C8_uc010qod.1_5'UTR	NM_000770	NP_000761	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C,	78					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding				0		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	TCATATCCATGAAACACCACT	0.418													20	21					0	0	1	0	0
SORBS1	10580	broad.mit.edu	37	10	97096387	97096387	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:97096387G>A	uc001kkp.2	-	28	3575	c.3530C>T	c.(3529-3531)CCC>CTC	p.P1177L	SORBS1_uc001kkk.2_Intron|SORBS1_uc001kkl.2_Intron|SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Intron|SORBS1_uc001kko.2_Missense_Mutation_p.P1036L|SORBS1_uc001kkq.2_Intron|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_Intron|SORBS1_uc001kku.2_Intron|SORBS1_uc001kkv.2_Intron|SORBS1_uc001kkw.2_Missense_Mutation_p.P1131L|SORBS1_uc010qoe.1_Intron	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	1177					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		GGGCTTGCCGGGCCGGCTCTC	0.587													51	79					0	0	1	0	0
TLL2	7093	broad.mit.edu	37	10	98145823	98145823	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:98145823C>T	uc001kml.1	-	15	2228	c.2002G>A	c.(2002-2004)GAA>AAA	p.E668K		NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	668	CUB 3.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		TCATTGCCTTCCAGTTCAAAC	0.537													18	25					0	0	1	0	0
TLL2	7093	broad.mit.edu	37	10	98155083	98155083	+	Silent	SNP	C	T	T	rs151335014		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:98155083C>T	uc001kml.1	-	13	1813	c.1587G>A	c.(1585-1587)ACG>ACA	p.T529T	TLL2_uc009xvf.1_Silent_p.T507T	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	529	CUB 2.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		CACTCTCTTCCGTGGGGCCAT	0.527													31	42					0	0	1	0	0
CRTAC1	55118	broad.mit.edu	37	10	99770906	99770906	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:99770906G>A	uc001kou.1	-	2	569	c.213C>T	c.(211-213)ATC>ATT	p.I71I	CRTAC1_uc001kov.2_Silent_p.I60I	NM_018058	NP_060528	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1 precursor	71	FG-GAP 1; atypical.					proteinaceous extracellular matrix	calcium ion binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		CCGCCACGACGATCTCAAAGT	0.408													38	54					0	0	1	0	0
HPSE2	60495	broad.mit.edu	37	10	100249954	100249954	+	Splice_Site	SNP	C	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:100249954C>A	uc001kpn.1	-	10	1381	c.1321_splice	c.e10-1	p.D441_splice	HPSE2_uc009xwc.1_Splice_Site_p.D431_splice|HPSE2_uc001kpo.1_Splice_Site_p.D373_splice|HPSE2_uc009xwd.1_Splice_Site_p.D319_splice	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2						carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		GCCAGTAGTCCTGAGGAGAAT	0.502													12	32					4.36969e-10	4.44305e-10	1	1	0
ABCC2	1244	broad.mit.edu	37	10	101544502	101544502	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:101544502G>A	uc001kqf.2	+	2	310	c.171G>A	c.(169-171)AAG>AAA	p.K57K		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	57	Cytoplasmic (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CCAGGACCAAGAGATCCTCTA	0.468													32	30					0	0	1	0	0
SEC31B	25956	broad.mit.edu	37	10	102265162	102265162	+	Nonsense_Mutation	SNP	T	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:102265162T>A	uc001krc.1	-	10	1237	c.1135A>T	c.(1135-1137)AAA>TAA	p.K379*	SEC31B_uc010qpo.1_Nonsense_Mutation_p.K378*|SEC31B_uc001krd.1_5'UTR|SEC31B_uc001krf.1_5'UTR|SEC31B_uc001kre.1_5'UTR|SEC31B_uc001krg.1_5'UTR|SEC31B_uc010qpp.1_3'UTR|SEC31B_uc009xwn.1_3'UTR|SEC31B_uc009xwo.1_3'UTR|SEC31B_uc010qpq.1_3'UTR	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	379					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		TTGGGGGGTTTTTTCAGGGGA	0.423													113	138					0	0	1	0	0
SEMA4G	57715	broad.mit.edu	37	10	102743450	102743450	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:102743450C>T	uc001krw.1	+	14	2478	c.2094C>T	c.(2092-2094)TCC>TCT	p.S698S	SEMA4G_uc001krv.2_RNA|SEMA4G_uc001krx.2_Intron|MRPL43_uc001kry.1_Intron|MRPL43_uc010qpu.1_Intron|MRPL43_uc001krz.1_Intron|MRPL43_uc001ksa.1_Intron|MRPL43_uc001ksb.1_Intron	NM_017893	NP_060363	Q9NTN9	SEM4G_HUMAN	semaphorin 4G	693	Helical; (Potential).				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)	1		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)		TCCTGGCCTCCTCCCTCCTCT	0.647													6	13					0	0	1	0	0
MGEA5	10724	broad.mit.edu	37	10	103546243	103546243	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:103546243G>A	uc001ktv.2	-	16	3159	c.2716C>T	c.(2716-2718)CCA>TCA	p.P906S	MGEA5_uc001ktu.2_RNA|MGEA5_uc010qqe.1_Missense_Mutation_p.P853S|MGEA5_uc009xws.2_Missense_Mutation_p.P839S	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	906	Histone acetyltransferase activity (By similarity).				glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		ACATCCTTTGGAAATCCTTCC	0.413													31	39					0	0	1	0	0
LDB1	8861	broad.mit.edu	37	10	103869429	103869429	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:103869429G>A	uc009xwz.2	-	8	1003	c.660C>T	c.(658-660)CCC>CCT	p.P220P	LDB1_uc001kuk.3_Silent_p.P184P|LDB1_uc001kul.3_Silent_p.P184P	NM_001113407	NP_001106878	Q86U70	LDB1_HUMAN	LIM domain binding 1 isoform 1	220					histone H3-K4 acetylation|negative regulation of erythrocyte differentiation|negative regulation of transcription, DNA-dependent|positive regulation of hemoglobin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription elongation, DNA-dependent|transcription, DNA-dependent|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nuclear chromatin|protein complex	LIM domain binding|protein homodimerization activity|transcription corepressor activity			large_intestine(1)	1		Colorectal(252;0.122)		Epithelial(162;1.11e-07)|all cancers(201;1.82e-06)		CCAACATCTGGGGGTCTTGGG	0.532													35	52					0	0	1	0	0
C10orf79	80217	broad.mit.edu	37	10	105947086	105947086	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:105947086G>A	uc001kxw.2	-	14	1968	c.1852C>T	c.(1852-1854)CCT>TCT	p.P618S	C10orf79_uc009xxq.2_5'Flank|C10orf79_uc001kxx.3_Missense_Mutation_p.P619S	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	618											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		ACTTCTTCAGGAAGAAGGTAG	0.398													13	26					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106130763	106130763	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:106130763C>T	uc001kyh.2	+	7	1175	c.1041C>T	c.(1039-1041)GTC>GTT	p.V347V		NM_001008723	NP_001008723	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	347	Potential.									ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		AGGCAGAAGTCGAACAGCACA	0.378													9	16					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106917019	106917019	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:106917019G>C	uc001kyi.1	+	10	1833	c.1606G>C	c.(1606-1608)GGA>CGA	p.G536R		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	536	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GGACCTGAGAGGAAGCCCAGT	0.567													11	21					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106927072	106927072	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:106927072C>T	uc001kyi.1	+	13	2093	c.1866C>T	c.(1864-1866)GCC>GCT	p.A622A		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	622	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CCCTCGTGGCCATGAAACACA	0.388													11	22					0	0	1	0	0
TCF7L2	6934	broad.mit.edu	37	10	114905824	114905824	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:114905824C>T	uc001lae.3	+	8	1350	c.843C>T	c.(841-843)CCC>CCT	p.P281P	TCF7L2_uc001lac.3_Silent_p.P258P|TCF7L2_uc010qrk.1_Silent_p.P258P|TCF7L2_uc010qrl.1_Silent_p.P258P|TCF7L2_uc010qrm.1_Silent_p.P281P|TCF7L2_uc010qrn.1_Silent_p.P224P|TCF7L2_uc001lad.3_Silent_p.P254P|TCF7L2_uc001lag.3_Silent_p.P305P|TCF7L2_uc001laf.3_Silent_p.P258P|TCF7L2_uc010qro.1_Silent_p.P258P|TCF7L2_uc001lah.2_Silent_p.P258P|TCF7L2_uc010qrp.1_Silent_p.P258P|TCF7L2_uc010qrq.1_Silent_p.P254P|TCF7L2_uc010qrr.1_Silent_p.P196P|TCF7L2_uc010qrs.1_Silent_p.P152P|TCF7L2_uc010qrt.1_Silent_p.P152P|TCF7L2_uc010qru.1_Silent_p.P175P|TCF7L2_uc010qrv.1_Silent_p.P98P|TCF7L2_uc010qrw.1_5'UTR|TCF7L2_uc010qrx.1_Silent_p.P138P	NM_001146274	NP_001139746	Q9NQB0	TF7L2_HUMAN	transcription factor 7-like 2 isoform 1	281	Mediates interaction with MAD2L2.|Pro-rich.				anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			large_intestine(3)|ovary(1)	4		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)		ACCCCTACCCCACAGCTCTGA	0.517													63	95					0	0	1	0	0
HABP2	3026	broad.mit.edu	37	10	115337808	115337808	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:115337808C>T	uc001lai.3	+	6	575	c.472C>T	c.(472-474)CCC>TCC	p.P158S	HABP2_uc010qrz.1_RNA|HABP2_uc010qry.1_Silent_p.T146T	NM_004132	NP_004123	Q14520	HABP2_HUMAN	hyaluronan binding protein 2 preproprotein	158	EGF-like 3.				cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		CAGGCCAAACCCCTGCCAGAA	0.532													26	39					0	0	1	0	0
VWA2	340706	broad.mit.edu	37	10	116048881	116048881	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:116048881G>A	uc001lbl.1	+	12	2076	c.1755G>A	c.(1753-1755)CTG>CTA	p.L585L	VWA2_uc001lbk.1_Silent_p.L585L|VWA2_uc009xyf.1_Silent_p.L281L	NM_198496	NP_940898	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	585	VWFA 3.					extracellular region				ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5				Epithelial(162;0.036)|all cancers(201;0.0793)		CCTTCGGGCTGGACACCAAAC	0.642													13	20					0	0	1	0	0
ABLIM1	3983	broad.mit.edu	37	10	116196096	116196096	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:116196096C>T	uc010qsg.1	-	22	2359	c.2260G>A	c.(2260-2262)GGA>AGA	p.G754R	ABLIM1_uc010qsh.1_Missense_Mutation_p.G722R|ABLIM1_uc010qsi.1_Missense_Mutation_p.G694R|ABLIM1_uc010qsf.1_Missense_Mutation_p.G431R	NM_002313	NP_002304	O14639	ABLM1_HUMAN	actin-binding LIM protein 1 isoform a	754	HP.				axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(1)	1		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		ATGGACATTCCAAAGATTTCC	0.448													29	44					0	0	1	0	0
PNLIPRP2	5408	broad.mit.edu	37	10	118394431	118394431	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:118394431C>T	uc001lcq.2	+	11	923	c.900C>T	c.(898-900)TTC>TTT	p.F300F	PNLIPRP2_uc009xyu.1_RNA|PNLIPRP2_uc009xyv.1_RNA	NM_005396	NP_005387	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2	299					galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)		CTGATGGCTTCCTGGGCTATC	0.502													12	21					0	0	1	0	0
FGFR2	2263	broad.mit.edu	37	10	123324046	123324046	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:123324046C>T	uc010qtk.1	-	4	1071	c.424G>A	c.(424-426)GAT>AAT	p.D142N	FGFR2_uc010qtg.1_Missense_Mutation_p.D142N|FGFR2_uc010qth.1_Intron|FGFR2_uc010qti.1_Missense_Mutation_p.D53N|FGFR2_uc010qtj.1_Missense_Mutation_p.D142N|FGFR2_uc010qtl.1_Missense_Mutation_p.D142N|FGFR2_uc010qtm.1_Intron|FGFR2_uc001lfl.3_Missense_Mutation_p.D142N|FGFR2_uc001lfm.2_Missense_Mutation_p.D53N|FGFR2_uc001lfn.3_Intron|FGFR2_uc010qtn.1_Missense_Mutation_p.D161N|FGFR2_uc010qto.1_Intron|FGFR2_uc001lfo.1_Missense_Mutation_p.D161N|FGFR2_uc010qtp.1_Missense_Mutation_p.D161N|FGFR2_uc010qtq.1_Missense_Mutation_p.D161N	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	142	Extracellular (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	CTGACAAAATCTTCCGCACCA	0.478		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				49	82					0	0	1	0	0
ATE1	11101	broad.mit.edu	37	10	123670525	123670525	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:123670525T>C	uc001lfp.2	-	5	561	c.479A>G	c.(478-480)AAA>AGA	p.K160R	ATE1_uc001lfq.2_Missense_Mutation_p.K160R|ATE1_uc010qtr.1_Missense_Mutation_p.K45R|ATE1_uc010qts.1_Missense_Mutation_p.K64R|ATE1_uc010qtt.1_Missense_Mutation_p.K153R|ATE1_uc001lfr.2_5'UTR|ATE1_uc009xzu.2_Intron	NM_007041	NP_008972	O95260	ATE1_HUMAN	arginyltransferase 1 isoform 2	160					protein arginylation	cytoplasm|nucleus	acyltransferase activity|arginyltransferase activity				0		all_neural(114;0.061)|Lung NSC(174;0.095)|all_lung(145;0.124)|Breast(234;0.212)				AGGTTCTTCTTTCTTTGAATT	0.373													23	34					0	0	1	0	0
FAM53B	9679	broad.mit.edu	37	10	126370273	126370273	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:126370273G>A	uc001lhv.1	-	4	1332	c.809C>T	c.(808-810)CCG>CTG	p.P270L	FAM53B_uc001lhu.1_Missense_Mutation_p.P270L|FAM53B_uc001lhw.2_Missense_Mutation_p.P270L	NM_014661	NP_055476	Q14153	FA53B_HUMAN	hypothetical protein LOC9679	270										ovary(1)|pancreas(1)	2		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		AAGGACACACGGCTGGGAGCG	0.582													4	5					0	0	1	0	0
DPYSL4	10570	broad.mit.edu	37	10	134016275	134016275	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:134016275C>T	uc009ybb.2	+	12	1561	c.1407C>T	c.(1405-1407)GTC>GTT	p.V469V		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	469					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		GCCGCTTCGTCCCTCGGAAAA	0.642													43	44					0	0	1	0	0
Unknown	0	broad.mit.edu	37	10	134648171	134648171	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:134648171G>A	uc010qux.1	-	40	6031	c.6031C>T	c.(6031-6033)CTC>TTC	p.L2011F		NM_017609	NP_060079			Homo sapiens cDNA, FLJ17989.																		GCCTTGGAGAGGCTGAGCAGG	0.642													13	13					0	0	1	0	0
ADAM8	101	broad.mit.edu	37	10	135087705	135087705	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:135087705C>T	uc010qva.1	-	2	132	c.81G>A	c.(79-81)TGG>TGA	p.W27*	ADAM8_uc010quz.1_Missense_Mutation_p.G62E|ADAM8_uc009ybi.2_Missense_Mutation_p.G62E|ADAM8_uc010qvb.1_Missense_Mutation_p.G37E|ADAM8_uc009ybj.1_RNA			P78325	ADAM8_HUMAN	SubName: Full=cDNA FLJ50704, highly similar to ADAM 8 (EC 3.4.24.-) (A disintegrinand metalloproteinase domain 8);	27					integrin-mediated signaling pathway|proteolysis		metalloendopeptidase activity			large_intestine(2)|central_nervous_system(1)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;7.72e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.23e-06)|Epithelial(32;1.02e-05)		CCCTGTGGCCCCAAGGACGTA	0.687													19	30					0	0	1	0	0
TALDO1	6888	broad.mit.edu	37	11	764334	764334	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:764334C>T	uc001lqz.2	+	7	932	c.882C>T	c.(880-882)TTC>TTT	p.F294F	TALDO1_uc001lra.2_Missense_Mutation_p.S293F	NM_006755	NP_006746	P37837	TALDO_HUMAN	transaldolase 1	294					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;4.66e-26)|Epithelial(43;2.97e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.48e-19)|BRCA - Breast invasive adenocarcinoma(625;4.41e-05)|Lung(200;0.0595)|LUSC - Lung squamous cell carcinoma(625;0.0712)		AGAAGTCTTTCCGTTGGTTGC	0.572													27	34					0	0	1	0	0
AP2A2	161	broad.mit.edu	37	11	985546	985546	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:985546T>G	uc001lss.2	+	8	1107	c.926T>G	c.(925-927)CTC>CGC	p.L309R	AP2A2_uc001lst.1_Missense_Mutation_p.L310R|AP2A2_uc009yco.1_RNA	NM_012305	NP_036437	O94973	AP2A2_HUMAN	adaptor-related protein complex 2, alpha 2	309					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	lipid binding|protein transporter activity				0		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.75e-24)|BRCA - Breast invasive adenocarcinoma(625;5.73e-05)|Lung(200;0.0696)|LUSC - Lung squamous cell carcinoma(625;0.082)		AATGCCGTGCTCTTCGAGGCC	0.577													22	23					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1251274	1251274	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:1251274G>A	uc009ycr.1	+	27	3363	c.3237G>A	c.(3235-3237)CCG>CCA	p.P1079P	MUC5B_uc009yct.1_Silent_p.P420P|MUC5B_uc001ltb.2_Silent_p.P423P|MUC5B_uc001lta.2_Silent_p.P88P	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	420					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		AGGACCTGCCGTGCCCTGGCA	0.657													21	23					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1263990	1263990	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:1263990G>A	uc009ycr.1	+	47	8085	c.7959G>A	c.(7957-7959)GGG>GGA	p.G2653G	MUC5B_uc001ltb.2_Silent_p.G1963G	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1960	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCAGTCCAGGGACTGCAACCG	0.637													105	86					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1265445	1265445	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:1265445G>A	uc009ycr.1	+	48	9375	c.9249G>A	c.(9247-9249)ACG>ACA	p.T3083T	MUC5B_uc001ltb.2_Silent_p.T2448T	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	2445	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CAGCCACTACGACTGAGTCCA	0.672													71	124					0	0	1	0	0
CTSD	1509	broad.mit.edu	37	11	1775285	1775286	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:1775285_1775286GG>AA	uc001luc.1	-	7	1043_1044	c.910_911CC>TT	c.(910-912)CCG>TTG	p.P304L	CTSD_uc009yda.1_RNA	NM_001909	NP_001900	P07339	CATD_HUMAN	cathepsin D preproprotein	304					cell death|proteolysis	extracellular space|lysosome|melanosome	aspartic-type endopeptidase activity				0		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTCATCCACCGGGCCCACCATG	0.604													14	14					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3707375	3707375	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:3707375G>A	uc001lyh.2	-	29	4795	c.4504C>T	c.(4504-4506)CCT>TCT	p.P1502S	NUP98_uc001lyi.2_Intron|NUP98_uc001lyg.2_Missense_Mutation_p.P467S	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	1519					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		TAGTCCAAAGGATCTGCTGTT	0.522			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								25	52					0	0	1	0	0
OR52B4	143496	broad.mit.edu	37	11	4388870	4388870	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:4388870G>A	uc010qye.1	-	1	656	c.656C>T	c.(655-657)TCC>TTC	p.S219F		NM_001005161	NP_001005161	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B,	219	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAGCATATAGGAAATAAAAAT	0.408													3	10					0	0	1	0	0
OR52K2	119774	broad.mit.edu	37	11	4471397	4471397	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:4471397C>T	uc001lyz.1	+	1	828	c.828C>T	c.(826-828)ATC>ATT	p.I276I		NM_001005172	NP_001005172	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K,	276	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATGTCCACATCCTCCTTGCCA	0.498													79	100					0	0	1	0	0
OR51E1	143503	broad.mit.edu	37	11	4674278	4674278	+	Silent	SNP	C	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:4674278C>G	uc001lzi.3	+	2	666	c.522C>G	c.(520-522)TCC>TCG	p.S174S		NM_152430	NP_689643	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E,	173	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|pancreas(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCTGCCGCTCCAATATCCTTT	0.537													99	82					0	0	1	0	0
OR51G1	79324	broad.mit.edu	37	11	4945015	4945015	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:4945015C>G	uc010qyr.1	-	1	555	c.555G>C	c.(553-555)GAG>GAC	p.E185D		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	185	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCTTCATGATCTCCAGGTGAA	0.517													6	14					0	0	1	0	0
OR51L1	119682	broad.mit.edu	37	11	5021092	5021092	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:5021092T>A	uc010qyu.1	+	1	880	c.880T>A	c.(880-882)TAT>AAT	p.Y294N		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	294	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCCTATTGTCTATAGTGTCAG	0.453													13	35					0	0	1	0	0
OR51L1	119682	broad.mit.edu	37	11	5021131	5021131	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:5021131C>T	uc010qyu.1	+	1	919	c.919C>T	c.(919-921)CAC>TAC	p.H307Y		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	307	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGGAATTCTCCACAAGTTTGT	0.403													22	9					0	0	1	0	0
OR51Q1	390061	broad.mit.edu	37	11	5444341	5444341	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:5444341G>A	uc010qzd.1	+	1	911	c.911G>A	c.(910-912)GGA>GAA	p.G304E	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004757	NP_001004757	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q,	304	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATCCAATGGGGAATGTTAAAT	0.418													16	5					0	0	1	0	0
OR56B1	387748	broad.mit.edu	37	11	5758698	5758698	+	Missense_Mutation	SNP	C	T	T	rs148131819		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:5758698C>T	uc001mbt.1	+	1	952	c.952C>T	c.(952-954)CTT>TTT	p.L318F	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005180	NP_001005180	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B,	318	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		GCTGTTTGCCCTTACAAAAGA	0.408													35	29					0	0	1	0	0
OR52B2	255725	broad.mit.edu	37	11	6190872	6190872	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:6190872G>A	uc010qzy.1	-	1	685	c.685C>T	c.(685-687)CGT>TGT	p.R229C		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGGGCAAACGAAACACTGCT	0.478													7	16					0	0	1	0	0
APBB1	322	broad.mit.edu	37	11	6422613	6422613	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:6422613G>A	uc001mdb.1	-	10	1650	c.1550C>T	c.(1549-1551)TCC>TTC	p.S517F	APBB1_uc001mcz.1_Missense_Mutation_p.S136F|APBB1_uc001mdd.3_Missense_Mutation_p.S295F|APBB1_uc001mda.2_Missense_Mutation_p.S42F|APBB1_uc001mdc.1_Missense_Mutation_p.S515F|APBB1_uc010rab.1_Missense_Mutation_p.S42F|APBB1_uc010rac.1_RNA|APBB1_uc010rad.1_Missense_Mutation_p.S234F	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	517					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		GTGGTCCAGGGAGAGTCCATT	0.547													33	50					0	0	1	0	0
DCHS1	8642	broad.mit.edu	37	11	6661491	6661492	+	Silent	DNP	GT	AA	AA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:6661491_6661492GT>AA	uc001mem.1	-	2	1763_1764	c.1353_1354AC>TT	c.(1351-1356)CCACTG>CCTTTG	p.451_452PL>PL		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	451_452	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCAGCCCGCAGTGGAGGTGAGC	0.589													6	10					0	0	1	0	0
OR6A2	8590	broad.mit.edu	37	11	6816306	6816306	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:6816306G>A	uc001mes.1	-	1	834	c.634C>T	c.(634-636)CTT>TTT	p.L212F		NM_003696	NP_003687	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GGCCCTAGAAGAATAAAAATG	0.488													27	37					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7063813	7063813	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:7063813G>A	uc001mfb.1	+	4	879	c.556G>A	c.(556-558)GGA>AGA	p.G186R		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	186	ATP (Potential).|NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GGGAGCTGCTGGAGTTGGGAA	0.463													42	37					0	0	1	0	0
OVCH2	341277	broad.mit.edu	37	11	7727857	7727857	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:7727857T>C	uc010rbf.1	-	1	85	c.85A>G	c.(85-87)AAA>GAA	p.K29E		NM_198185	NP_937828			ovochymase 2 precursor												0				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		AACTTACCTTTGGGGAGCGAA	0.393													3	5					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7982674	7982674	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:7982674G>A	uc001mfv.1	-	2	502	c.485C>T	c.(484-486)CCC>CTC	p.P162L		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	162							ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GGCCAGTGAGGGCTTTTCCCC	0.577													13	16					0	0	1	0	0
TUB	7275	broad.mit.edu	37	11	8060559	8060559	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:8060559G>A	uc001mfy.2	+	1	380	c.139G>A	c.(139-141)GGC>AGC	p.G47S	TUB_uc010rbk.1_Intron	NM_003320	NP_003311	P50607	TUB_HUMAN	tubby isoform a	Error:Variant_position_missing_in_P50607_after_alignment					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				ovary(1)	1		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		CCTGAAACGGGGCCACCGAAG	0.572													19	8					0	0	1	0	0
LYVE1	10894	broad.mit.edu	37	11	10582264	10582264	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:10582264C>T	uc001miv.2	-	4	767	c.481G>A	c.(481-483)GAA>AAA	p.E161K	uc001miu.2_Intron|LYVE1_uc010rca.1_Missense_Mutation_p.E57K	NM_006691	NP_006682	Q9Y5Y7	LYVE1_HUMAN	lymphatic vessel endothelial hyaluronan receptor	161	Extracellular (Potential).				anatomical structure morphogenesis|cell-matrix adhesion|cellular component movement|response to wounding|transport	integral to plasma membrane|membrane fraction				central_nervous_system(1)|skin(1)	2				all cancers(16;7.22e-08)|Epithelial(150;1.03e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0609)		ACAATAAATTCTGTTGTTTGT	0.443													65	56					0	0	1	0	0
MRVI1	10335	broad.mit.edu	37	11	10613143	10613143	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:10613143C>T	uc010rcc.1	-	18	2578	c.2192G>A	c.(2191-2193)GGG>GAG	p.G731E	uc001miu.2_Intron|MRVI1_uc001miw.2_Missense_Mutation_p.G722E|MRVI1_uc010rcb.1_Missense_Mutation_p.G723E|MRVI1_uc009ygb.1_Missense_Mutation_p.G416E|MRVI1_uc001mix.2_Missense_Mutation_p.G416E|MRVI1_uc001miz.2_Missense_Mutation_p.G640E|MRVI1_uc009ygc.1_Missense_Mutation_p.G640E|MRVI1_uc010rcd.1_Missense_Mutation_p.G525E|MRVI1_uc009ygd.1_Missense_Mutation_p.G416E|MRVI1_uc010rce.1_RNA	NM_001100167	NP_001093637	Q9Y6F6	MRVI1_HUMAN	JAW1-related protein isoform c	704					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				ovary(2)|central_nervous_system(1)	3				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		GCTGCCTTTCCCATTGGGTGA	0.473													2	2					0	0	1	0	0
CTR9	9646	broad.mit.edu	37	11	10785932	10785932	+	Silent	SNP	C	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:10785932C>A	uc001mja.2	+	11	1511	c.1362C>A	c.(1360-1362)CTC>CTA	p.L454L		NM_014633	NP_055448	Q6PD62	CTR9_HUMAN	SH2 domain binding protein 1	454	TPR 9.				histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				ovary(2)	2				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		CAGAGATTCTCAATAATGTGG	0.428													21	35					7.26314e-15	7.42846e-15	1	1	0
FAR1	84188	broad.mit.edu	37	11	13736177	13736178	+	Missense_Mutation	DNP	CC	TT	TT	rs146816221	byFrequency	TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:13736177_13736178CC>TT	uc001mld.2	+	9	1232_1233	c.1077_1078CC>TT	c.(1075-1080)GCCCCA>GCTTCA	p.P360S		NM_032228	NP_115604	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	360					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			ovary(1)|skin(1)	2						GCCATAAGGCCCCAGCATTCCT	0.446													12	14					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16838749	16838749	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:16838749G>A	uc001mmo.2	-	11	1479	c.1464C>T	c.(1462-1464)CCC>CCT	p.P488P	PLEKHA7_uc010rcu.1_Silent_p.P488P|PLEKHA7_uc010rcv.1_Silent_p.P62P|PLEKHA7_uc001mmn.2_Silent_p.P196P	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	488					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						GCAGGTTTCGGGGAGGTGGCG	0.637													64	50					0	0	1	0	0
USH1C	10083	broad.mit.edu	37	11	17548864	17548864	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:17548864G>A	uc001mnf.2	-	5	511	c.402C>T	c.(400-402)ATC>ATT	p.I134I	USH1C_uc001mne.2_Silent_p.I134I|USH1C_uc009yhb.2_Silent_p.I134I|USH1C_uc001mng.2_RNA|USH1C_uc001mnd.2_Silent_p.I98I	NM_005709	NP_005700	Q9Y6N9	USH1C_HUMAN	harmonin isoform a	134	PDZ 1.				equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1						TGATCCGGACGATCTCGTCCC	0.552													19	54					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20628605	20628605	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:20628605C>T	uc001mqd.2	+	4	1005	c.732C>T	c.(730-732)ATC>ATT	p.I244I	SLC6A5_uc009yic.2_Silent_p.I9I	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	244	Helical; Name=2; (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	GATTACCCATCTTCTTCTTGG	0.572													21	58					0	0	1	0	0
ANO5	203859	broad.mit.edu	37	11	22248889	22248889	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:22248889C>T	uc001mqi.2	+	7	722	c.405C>T	c.(403-405)GCC>GCT	p.A135A	ANO5_uc001mqj.2_Silent_p.A134A	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	135	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						AGATCCATGCCCCTTGGGAGG	0.413													14	17					0	0	1	0	0
SLC17A6	57084	broad.mit.edu	37	11	22363239	22363239	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:22363239C>T	uc001mqk.2	+	2	665	c.252C>T	c.(250-252)TCC>TCT	p.S84S		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	84	Helical; (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						TCTGCATCTCCTTCGGTATCC	0.632													37	21					0	0	1	0	0
LUZP2	338645	broad.mit.edu	37	11	24927579	24927579	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:24927579T>G	uc001mqs.2	+	6	673	c.439T>G	c.(439-441)TGT>GGT	p.C147G	LUZP2_uc009yif.2_Missense_Mutation_p.C61G|LUZP2_uc009yig.2_Intron	NM_001009909	NP_001009909	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2 precursor	147	Potential.					extracellular region				ovary(1)|skin(1)	2						AAACAAGCTCTGTGGCATTCA	0.328													22	21					0	0	1	0	0
Unknown	0	broad.mit.edu	37	11	31115691	31115691	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:31115691C>T	uc009yjk.1	-	4	437	c.368G>A	c.(367-369)GGA>GAA	p.G123E	uc009yjl.1_Missense_Mutation_p.G51E|DCDC1_uc001msu.1_Missense_Mutation_p.G294E					RecName: Full=Doublecortin domain-containing protein 5;																		ACTCCACTTTCCAATGGAAAC	0.448													16	26					0	0	1	0	0
C11orf41	25758	broad.mit.edu	37	11	33569341	33569341	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:33569341C>T	uc001mup.3	+	3	2668	c.2544C>T	c.(2542-2544)ATC>ATT	p.I848I	C11orf41_uc001mun.1_Silent_p.I848I	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	842						integral to membrane				ovary(2)	2						GAGTGCAGATCAGTGAATCCT	0.488													10	12					0	0	1	0	0
C11orf41	25758	broad.mit.edu	37	11	33581441	33581441	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:33581441G>A	uc001mup.3	+	6	3253	c.3129G>A	c.(3127-3129)CCG>CCA	p.P1043P	C11orf41_uc001mun.1_Silent_p.P1043P	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	1037						integral to membrane				ovary(2)	2						CCTATCCGCCGCTAACCATTG	0.567													4	217					0	0	1	0	0
PRR5L	79899	broad.mit.edu	37	11	36483943	36483943	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:36483943C>T	uc001mwo.3	+	9	1153	c.764C>T	c.(763-765)TCC>TTC	p.S255F	PRR5L_uc001mwp.2_Missense_Mutation_p.S255F|PRR5L_uc009ykk.2_Missense_Mutation_p.S127F|PRR5L_uc010rfc.1_3'UTR	NM_001160167	NP_001153639	Q6MZQ0	PRR5L_HUMAN	protor-2 isoform a	255										ovary(1)	1						AACTATGCCTCCCCGATAACC	0.587													27	70					0	0	1	0	0
RAG1	5896	broad.mit.edu	37	11	36595523	36595523	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:36595523G>A	uc001mwu.3	+	2	793	c.669G>A	c.(667-669)AGG>AGA	p.R223R	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	223	Interaction with importin alpha-1.				histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				GACTCAAGAGGAAGAGTCTTC	0.537									Familial_Hemophagocytic_Lymphohistiocytosis				15	34					0	0	1	0	0
RAG1	5896	broad.mit.edu	37	11	36595792	36595792	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:36595792G>A	uc001mwu.3	+	2	1062	c.938G>A	c.(937-939)TGC>TAC	p.C313Y	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	313	RING-type.	Zinc 2 (By similarity).			histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				CATGTCTTTTGCCGGGTCTGC	0.517									Familial_Hemophagocytic_Lymphohistiocytosis				21	28					0	0	1	0	0
OR4X2	119764	broad.mit.edu	37	11	48267270	48267270	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:48267270C>T	uc001ngs.1	+	1	615	c.615C>T	c.(613-615)GTC>GTT	p.V205V		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	205	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTTTTGGGGTCCTCTTAGCAT	0.527													20	45					0	0	1	0	0
LOC646813	646813	broad.mit.edu	37	11	50368795	50368795	+	RNA	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:50368795G>A	uc001nhe.2	+	2		c.99G>A			LOC646813_uc001nhf.1_RNA|LOC646813_uc001nhg.1_RNA	NR_024504				Homo sapiens mRNA for hypothetical protein, partial sequence, clone:Hsa11-digit09-11-09-R.												0						TGTAACTGTAGGTGAAATACA	0.318													7	3					0	0	1	0	0
OR4A5	81318	broad.mit.edu	37	11	51412038	51412038	+	Missense_Mutation	SNP	G	A	A	rs141762692		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:51412038G>A	uc001nhi.1	-	1	358	c.358C>T	c.(358-360)CGC>TGC	p.R120C		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	120	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				GCCACATAGCGATCACAGGCC	0.468													11	20					0	0	1	0	0
OR4A16	81327	broad.mit.edu	37	11	55110913	55110913	+	Silent	SNP	G	A	A	rs142044895		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:55110913G>A	uc010rie.1	+	1	237	c.237G>A	c.(235-237)TTG>TTA	p.L79L		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	79	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						CACCCAAATTGATGATAGACT	0.448													25	28					0	0	1	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735130	55735130	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:55735130G>A	uc010rit.1	-	1	810	c.810C>T	c.(808-810)ACC>ACT	p.T270T		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	270	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					GAATCAGAATGGTGTAGAAAA	0.348													9	21					0	0	1	0	0
OR5AK2	390181	broad.mit.edu	37	11	56756838	56756838	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:56756838C>T	uc010rjp.1	+	1	450	c.450C>T	c.(448-450)ATC>ATT	p.I150I		NM_001005323	NP_001005323	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						GTTCATACATCATGGGCTCAA	0.438													31	54					0	0	1	0	0
C11orf31	280636	broad.mit.edu	37	11	57509641	57509641	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:57509641C>T	uc010rjx.1	+	4	667	c.321C>T	c.(319-321)TTC>TTT	p.F107F	CTNND1_uc001nlf.1_Intron	NM_170746	NP_734467	Q8IZQ5	SELH_HUMAN	selenoprotein H	107					cell redox homeostasis		selenium binding				0						AACTCAAATTCCCTGAGCCTC	0.527													4	9					0	0	1	0	0
GLYAT	10249	broad.mit.edu	37	11	58491917	58491917	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:58491917A>G	uc001nnb.2	-	2	208	c.53T>C	c.(52-54)TTG>TCG	p.L18S	GLYAT_uc001nnc.2_Missense_Mutation_p.L18S	NM_201648	NP_964011	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase isoform a	18					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	GCTCTTCCTCAAGGATTTCTC	0.443													18	13					0	0	1	0	0
OSBP	5007	broad.mit.edu	37	11	59348961	59348961	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:59348961A>G	uc001noc.1	-	10	2225	c.1745T>C	c.(1744-1746)GTA>GCA	p.V582A	OSBP_uc009ymr.1_RNA	NM_002556	NP_002547	P22059	OSBP1_HUMAN	oxysterol binding protein	582					lipid transport	Golgi membrane	oxysterol binding			large_intestine(1)	1		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		AATGTTGTGTACAGTTGTGGT	0.393													3	121					0	0	1	0	0
MS4A10	341116	broad.mit.edu	37	11	60567351	60567351	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:60567351G>A	uc001npz.1	+	8	869	c.773G>A	c.(772-774)GGA>GAA	p.G258E		NM_206893	NP_996776	Q96PG2	M4A10_HUMAN	membrane-spanning 4-domains, subfamily A, member	258	Cytoplasmic (Potential).					integral to membrane	receptor activity			ovary(1)|skin(1)	2						gtcactgacggagctgcgatc	0.204													5	19					0	0	1	0	0
CCDC86	79080	broad.mit.edu	37	11	60609844	60609844	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:60609844G>A	uc001nqa.2	+	1	416	c.247G>A	c.(247-249)GGG>AGG	p.G83R	CCDC86_uc001nqb.2_5'UTR	NM_024098	NP_077003	Q9H6F5	CCD86_HUMAN	coiled-coil domain containing 86	83	Pro-rich.				interspecies interaction between organisms	nucleus					0						GTCACCCCAAGGGCAGCCAGA	0.657													33	28					0	0	1	0	0
CPSF7	79869	broad.mit.edu	37	11	61183597	61183597	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:61183597G>A	uc001nrq.2	-	6	1079	c.945C>T	c.(943-945)GCC>GCT	p.A315A	CPSF7_uc001nro.2_Silent_p.A306A|CPSF7_uc001nrp.2_Silent_p.A358A|CPSF7_uc001nrr.2_Silent_p.A306A|CPSF7_uc001nrs.1_Silent_p.A216A	NM_001136040	NP_001129512	Q8N684	CPSF7_HUMAN	pre-mRNA cleavage factor I, 59 kDa subunit	315	Pro-rich.				mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						GGTTATAGGGGGCAGAGGCCT	0.507													34	56					0	0	1	0	0
FADS3	3995	broad.mit.edu	37	11	61643878	61643878	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:61643878G>A	uc001nsm.2	-	9	1186	c.1033C>T	c.(1033-1035)CCC>TCC	p.P345S	FADS3_uc001nsn.2_Missense_Mutation_p.P221S	NM_021727	NP_068373	Q9Y5Q0	FADS3_HUMAN	fatty acid desaturase 3	345	Cytoplasmic (Potential).				electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	heme binding|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water			ovary(1)|pancreas(1)	2						ATCTCCTTGGGGATGTGGTTC	0.652													24	88					0	0	1	0	0
MTA2	9219	broad.mit.edu	37	11	62361854	62361854	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:62361854G>A	uc001ntq.1	-	17	2099	c.1718C>T	c.(1717-1719)TCT>TTT	p.S573F	TUT1_uc001nto.2_5'Flank|MTA2_uc010rlx.1_Missense_Mutation_p.S400F	NM_004739	NP_004730	O94776	MTA2_HUMAN	metastasis-associated protein 2	573					chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TCCATTGGCAGAGAAAGGAAC	0.557													11	13					0	0	1	0	0
PLA2G16	11145	broad.mit.edu	37	11	63357818	63357818	+	Silent	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:63357818T>C	uc001nxh.2	-	3	564	c.141A>G	c.(139-141)GCA>GCG	p.A47A	PLA2G16_uc001nxi.2_Silent_p.A59A|PLA2G16_uc009you.1_Silent_p.A47A	NM_007069	NP_009000	P53816	PAG16_HUMAN	HRAS-like suppressor 3	47					lipid catabolic process	integral to membrane|perinuclear region of cytoplasm	hydrolase activity|protein binding			ovary(1)	1						TGACACTGGCTGCACCAGCTC	0.582													12	29					0	0	1	0	0
ATL3	25923	broad.mit.edu	37	11	63426317	63426317	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:63426317G>A	uc001nxk.1	-	3	597	c.321C>T	c.(319-321)TCC>TCT	p.S107S	ATL3_uc010rms.1_Silent_p.S89S	NM_015459	NP_056274	Q6DD88	ATLA3_HUMAN	atlastin 3	107	Cytoplasmic.				endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			pancreas(1)	1						CCCCTCTCCAGGAAAATCCTG	0.403													42	88					0	0	1	0	0
PYGM	5837	broad.mit.edu	37	11	64520612	64520612	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:64520612G>A	uc001oax.3	-	12	2268	c.1451C>T	c.(1450-1452)ACC>ATC	p.T484I	PYGM_uc001oay.3_Missense_Mutation_p.T396I	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	484					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	GATGCCGTTGGTCTTATTCTG	0.567													99	205					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64663970	64663970	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:64663970G>A	uc001obx.2	-	39	5506	c.5391C>T	c.(5389-5391)GCC>GCT	p.A1797A	ATG2A_uc001obw.2_Silent_p.A562A	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1797							protein binding			ovary(1)|central_nervous_system(1)	2						TGAGTTCCAGGGCGGCAGAGG	0.637											OREG0004026	type=REGULATORY REGION|Gene=BC027481|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	8	12					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64676500	64676500	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:64676500G>A	uc001obx.2	-	16	2442	c.2327C>T	c.(2326-2328)CCC>CTC	p.P776L		NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	776							protein binding			ovary(1)|central_nervous_system(1)	2						AGAGGAGAAGGGCGAGGGCTC	0.642													11	5					0	0	1	0	0
TM7SF2	7108	broad.mit.edu	37	11	64882814	64882814	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:64882814G>A	uc001oct.2	+	8	1068	c.921G>A	c.(919-921)GCG>GCA	p.A307A	TM7SF2_uc010rny.1_Silent_p.A191A|TM7SF2_uc001ocu.2_Intron|TM7SF2_uc001ocv.2_Silent_p.A328A|uc009yqb.1_5'Flank	NM_003273	NP_003264	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	307					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			ovary(1)	1						TCCGTGGGGCGAATTCCCAGA	0.572													56	105					0	0	1	0	0
SLC25A45	283130	broad.mit.edu	37	11	65147339	65147339	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:65147339G>A	uc001odp.1	-	3	574	c.152C>T	c.(151-153)TCC>TTC	p.S51F	SLC25A45_uc009yqi.1_Missense_Mutation_p.S51F|SLC25A45_uc001odq.1_Intron|SLC25A45_uc001odr.1_Missense_Mutation_p.S51F|SLC25A45_uc001ods.1_Missense_Mutation_p.S9F|SLC25A45_uc001odt.1_Missense_Mutation_p.S9F	NM_001077241	NP_001070709	Q8N413	S2545_HUMAN	solute carrier family 25, member 45 isoform b	51	Solcar 1.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						GCCACTCACGGACTCATGGCG	0.612													34	26					0	0	1	0	0
ACTN3	89	broad.mit.edu	37	11	66330268	66330268	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:66330268G>A	uc001oio.1	+	21	2408	c.2390G>A	c.(2389-2391)GGG>GAG	p.G797E	ACTN3_uc010rpi.1_RNA	NM_001104	NP_001095	Q08043	ACTN3_HUMAN	actinin, alpha 3	797	EF-hand 2.				focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle				0						TCCCTGCAGGGGGAAGTGGAG	0.468													83	164					0	0	1	0	0
SPTBN2	6712	broad.mit.edu	37	11	66472843	66472843	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:66472843G>A	uc001ojd.2	-	14	1976	c.1904C>T	c.(1903-1905)GCC>GTC	p.A635V		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	635	Spectrin 3.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CTCCAGCCGGGCCCGCCGCGC	0.672													6	40					0	0	1	0	0
POLD4	57804	broad.mit.edu	37	11	67120853	67120853	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:67120853G>A	uc001okm.2	-	1	165	c.18C>T	c.(16-18)CTC>CTT	p.L6L	LOC100130987_uc010rpo.1_Intron|POLD4_uc001okn.2_RNA|POLD4_uc001oko.2_Intron|POLD4_uc001okp.1_Silent_p.L6L	NM_021173	NP_066996	Q9HCU8	DPOD4_HUMAN	DNA-directed DNA polymerase delta 4	6					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA-directed DNA polymerase activity|protein binding				0			BRCA - Breast invasive adenocarcinoma(15;3.08e-06)			AATCAGTGATGAGCCGCTTCC	0.662													18	37					0	0	1	0	0
RAD9A	5883	broad.mit.edu	37	11	67164707	67164707	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:67164707G>A	uc001okr.2	+	10	1023	c.930G>A	c.(928-930)ATG>ATA	p.M310I	RAD9A_uc001oks.2_Missense_Mutation_p.M167I	NM_004584	NP_004575	Q99638	RAD9A_HUMAN	RAD9 homolog	310	Sufficient for interaction with ABL1.				DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint	nucleoplasm	3'-5' exonuclease activity|exodeoxyribonuclease III activity|histone deacetylase binding|protein kinase binding|SH3 domain binding				0			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			TGATCGCCATGGAAACCACTA	0.612								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					23	73					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	69972190	69972190	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:69972190G>A	uc001opj.2	+	10	1291	c.986G>A	c.(985-987)GGC>GAC	p.G329D	ANO1_uc001opk.1_Missense_Mutation_p.G301D|ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_Missense_Mutation_p.G64D	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	329	Cytoplasmic (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						GAGAAGATCGGCCTGTACTTC	0.552													45	108					0	0	1	0	0
CTTN	2017	broad.mit.edu	37	11	70267599	70267599	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:70267599A>G	uc001opv.3	+	11	1020	c.814A>G	c.(814-816)AAA>GAA	p.K272E	CTTN_uc001opu.2_Intron|CTTN_uc001opw.3_Intron|CTTN_uc010rqm.1_Intron|CTTN_uc001opx.2_5'Flank	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	272	Cortactin 6.					cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		TTTTGGAGGCAAATTCGGTGT	0.502													129	282					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332481	70332481	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:70332481G>A	uc001oqc.2	-	21	3995	c.3917C>T	c.(3916-3918)TCC>TTC	p.S1306F	SHANK2_uc010rqn.1_Missense_Mutation_p.S718F|SHANK2_uc001opz.2_Missense_Mutation_p.S711F|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	927					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CTTCTGCTGGGACGTGTCCAT	0.597													39	90					0	0	1	0	0
ARRB1	408	broad.mit.edu	37	11	74983964	74983964	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:74983964C>T	uc001owe.1	-	12	1195	c.973G>A	c.(973-975)GTG>ATG	p.V325M	ARRB1_uc001owf.1_Missense_Mutation_p.V325M	NM_004041	NP_004032	P49407	ARRB1_HUMAN	arrestin beta 1 isoform A	325	Interaction with TRAF6.				G-protein coupled receptor internalization|histone H4 acetylation|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|positive regulation of histone acetylation|positive regulation of Rho protein signal transduction|positive regulation of transcription from RNA polymerase II promoter|post-Golgi vesicle-mediated transport|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|signal transduction|stress fiber assembly|transcription from RNA polymerase II promoter	chromatin|coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|membrane fraction|nucleus|plasma membrane|pseudopodium|soluble fraction	angiotensin receptor binding|enzyme inhibitor activity|GTPase activator activity|insulin-like growth factor receptor binding|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding			breast(2)	2						ACCAGCTTCACTTTCACTTTG	0.622													20	39					0	0	1	0	0
MAP6	4135	broad.mit.edu	37	11	75298473	75298473	+	Silent	SNP	T	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:75298473T>G	uc001owu.2	-	4	2138	c.2073A>C	c.(2071-2073)GCA>GCC	p.A691A		NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	691	Pro-rich.					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					CGTGAACCTTTGCATGCTCTG	0.473													34	52					0	0	1	0	0
PRKRIR	5612	broad.mit.edu	37	11	76072103	76072103	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:76072103G>A	uc001oxh.1	-	3	215	c.215C>T	c.(214-216)CCT>CTT	p.P72L	PRKRIR_uc010rrz.1_5'Flank	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double	72	THAP-type.				negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			ovary(2)|pancreas(1)	3						TGTCCTATAAGGACTCTGAAA	0.308													16	33					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102482568	102482568	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:102482568C>T	uc001phc.2	-	3	454	c.441G>A	c.(439-441)CAG>CAA	p.Q147Q		NM_004771	NP_004762	O60882	MMP20_HUMAN	matrix metalloproteinase 20 preproprotein	147					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			urinary_tract(1)|skin(1)	2	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		TACTCCAGGCCTGCAAGGCCA	0.438													23	3					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103048371	103048371	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:103048371G>A	uc001pho.2	+	38	6105	c.5961G>A	c.(5959-5961)ACG>ACA	p.T1987T	DYNC2H1_uc001phn.1_Silent_p.T1987T|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	1987	AAA 2 (By similarity).		T -> A (in SRPS3).		cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GAAAATCAACGCTTTGGAGAA	0.393													3	9					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103339354	103339354	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:103339354G>A	uc001pho.2	+	88	12830	c.12686G>A	c.(12685-12687)GGA>GAA	p.G4229E	DYNC2H1_uc001phn.1_Missense_Mutation_p.G4236E|DYNC2H1_uc009yxe.1_Missense_Mutation_p.G842E	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	4229					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AGTTTTGATGGAAATCAACTT	0.388													19	2					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113705054	113705054	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:113705054G>A	uc001poh.2	-	6	571	c.538C>T	c.(538-540)CTC>TTC	p.L180F	USP28_uc010rwy.1_Missense_Mutation_p.L55F|USP28_uc001poi.2_5'UTR|USP28_uc001poj.3_Missense_Mutation_p.L180F|USP28_uc010rwz.1_Missense_Mutation_p.L180F	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	180					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		AATTGAAAGAGAGACTGAAAT	0.318													6	3					0	0	1	0	0
ZNF259	8882	broad.mit.edu	37	11	116656545	116656545	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:116656545C>T	uc001ppp.2	-	5	582	c.549G>A	c.(547-549)AAG>AAA	p.K183K	ZNF259_uc009yzd.2_Silent_p.K183K|ZNF259_uc001ppq.2_Silent_p.K129K	NM_003904	NP_003895	O75312	ZPR1_HUMAN	zinc finger protein 259	183					cell proliferation|signal transduction	cytoplasm|nucleolus					0	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.61e-06)|all cancers(92;0.000139)|OV - Ovarian serous cystadenocarcinoma(223;0.153)		GCTTTAGCTCCTTCAGTTTGA	0.468													20	21					0	0	1	0	0
POU2F3	25833	broad.mit.edu	37	11	120175775	120175775	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:120175775G>A	uc001pxc.2	+	7	583	c.481G>A	c.(481-483)GAA>AAA	p.E161K	POU2F3_uc010rzk.1_Missense_Mutation_p.E115K|POU2F3_uc010rzl.1_Missense_Mutation_p.E91K|POU2F3_uc001pxe.1_5'Flank	NM_014352	NP_055167	Q9UKI9	PO2F3_HUMAN	POU transcription factor	161					negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding			ovary(1)|skin(1)	2		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		ATCCTCTTTAGAACCCCACCT	0.527													36	9					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121016408	121016408	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:121016408C>T	uc010rzo.1	+	11	3688	c.3688C>T	c.(3688-3690)CCT>TCT	p.P1230S		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1230	VWFD 3.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CATCACAGTCCCTCGGAGCAT	0.507													20	7					0	0	1	0	0
KCNJ5	3762	broad.mit.edu	37	11	128781893	128781894	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:128781893_128781894GG>AA	uc001qet.2	+	2	1039_1040	c.725_726GG>AA	c.(724-726)CGG>CAA	p.R242Q	KCNJ5_uc009zck.2_Missense_Mutation_p.R242Q|KCNJ5_uc001qew.2_Missense_Mutation_p.R242Q	NM_000890	NP_000881	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel J5	242	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	ATCAAGTCCCGGCAGACCAAAG	0.609													52	8					0	0	1	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130286925	130286925	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:130286925C>T	uc001qgg.3	-	3	1364	c.1006G>A	c.(1006-1008)GAC>AAC	p.D336N		NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	336	Peptidase M12B.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		GTCCCGATGTCTGCCACACCC	0.602													6	52					0	0	1	0	0
IGSF9B	22997	broad.mit.edu	37	11	133790479	133790479	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:133790479G>A	uc001qgx.3	-	18	3372	c.3141C>T	c.(3139-3141)TTC>TTT	p.F1047F		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1047	Pro-rich.|Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CCAGCCCCCCGAAGGGGAATT	0.657													42	5					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	333208	333208	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:333208G>A	uc001qic.1	-	11	1314	c.1261C>T	c.(1261-1263)CTT>TTT	p.L421F	SLC6A13_uc009zdj.1_Missense_Mutation_p.L411F|SLC6A13_uc010sdl.1_Missense_Mutation_p.L329F	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	421	Helical; Name=9; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			GATACTCCAAGGATGAGGACT	0.577													25	49					0	0	1	0	0
RAD52	5893	broad.mit.edu	37	12	1023639	1023639	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:1023639G>A	uc001qis.1	-	10	1039	c.925C>T	c.(925-927)CTG>TTG	p.L309L	RAD52_uc001qit.1_RNA|RAD52_uc010sdt.1_Silent_p.L232L|RAD52_uc001qiu.1_Silent_p.L309L|RAD52_uc001qiv.1_RNA|RAD52_uc001qiw.1_RNA	NM_134424	NP_602296	P43351	RAD52_HUMAN	RAD52 homolog	309					DNA recombinase assembly|mitotic recombination|reciprocal meiotic recombination	nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1	all_cancers(10;0.0119)|all_epithelial(11;0.0171)|all_lung(10;0.0521)|Ovarian(42;0.0816)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.0323)			TCTTTCTCCAGGAGTGGTTCT	0.478								Homologous_recombination					37	28					0	0	1	0	0
WNT5B	81029	broad.mit.edu	37	12	1755352	1755352	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:1755352C>T	uc009zdq.2	+	5	1256	c.1014C>T	c.(1012-1014)TTC>TTT	p.F338F	WNT5B_uc001qjj.2_Silent_p.F338F|WNT5B_uc001qjk.2_Silent_p.F338F|WNT5B_uc001qjl.2_Silent_p.F338F	NM_032642	NP_116031	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family,	338					angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)			ACTGCAAGTTCCACTGGTGCT	0.602													22	44					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1953652	1953652	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:1953652C>T	uc001qjp.2	-	25	2617	c.2386G>A	c.(2386-2388)GAC>AAC	p.D796N	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Missense_Mutation_p.D660N|CACNA2D4_uc009zdr.1_RNA	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	796	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		GGGAAGCGGTCCAGGGTGAAC	0.597													16	15					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2676817	2676817	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:2676817C>T	uc009zdu.1	+	13	2065	c.1752C>T	c.(1750-1752)TTC>TTT	p.F584F	CACNA1C_uc009zdv.1_Silent_p.F581F|CACNA1C_uc001qkb.2_Silent_p.F584F|CACNA1C_uc001qkc.2_Silent_p.F584F|CACNA1C_uc001qke.2_Silent_p.F584F|CACNA1C_uc001qkf.2_Silent_p.F584F|CACNA1C_uc001qjz.2_Silent_p.F584F|CACNA1C_uc001qkd.2_Silent_p.F584F|CACNA1C_uc001qkg.2_Silent_p.F584F|CACNA1C_uc009zdw.1_Silent_p.F584F|CACNA1C_uc001qkh.2_Silent_p.F584F|CACNA1C_uc001qkl.2_Silent_p.F584F|CACNA1C_uc001qkn.2_Silent_p.F584F|CACNA1C_uc001qko.2_Silent_p.F584F|CACNA1C_uc001qkp.2_Silent_p.F584F|CACNA1C_uc001qkr.2_Silent_p.F584F|CACNA1C_uc001qku.2_Silent_p.F584F|CACNA1C_uc001qkq.2_Silent_p.F584F|CACNA1C_uc001qks.2_Silent_p.F584F|CACNA1C_uc001qkt.2_Silent_p.F584F|CACNA1C_uc001qka.1_Silent_p.F119F|CACNA1C_uc001qki.1_Silent_p.F320F|CACNA1C_uc001qkj.1_Silent_p.F320F|CACNA1C_uc001qkk.1_Silent_p.F320F|CACNA1C_uc001qkm.1_Silent_p.F320F	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	584	II.|Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	AGGCCTACTTCGTGTCCCTCT	0.607													6	14					0	0	1	0	0
CCND2	894	broad.mit.edu	37	12	4383338	4383338	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:4383338C>T	uc001qmo.2	+	1	437	c.132C>T	c.(130-132)TTC>TTT	p.F44F		NM_001759	NP_001750	P30279	CCND2_HUMAN	cyclin D2	44	Cyclin N-terminal.				cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding			haematopoietic_and_lymphoid_tissue(1)|breast(1)|kidney(1)	3			all cancers(3;4.15e-10)|GBM - Glioblastoma multiforme(3;6.34e-05)|Colorectal(7;0.00245)|OV - Ovarian serous cystadenocarcinoma(31;0.00301)|COAD - Colon adenocarcinoma(12;0.0264)|STAD - Stomach adenocarcinoma(119;0.206)			GCTCCTACTTCAAGTGCGTGC	0.652			T	IGL@	NHL,CLL								50	55					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5756944	5756944	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:5756944C>T	uc001qnm.2	-	16	1641	c.1569G>A	c.(1567-1569)TGG>TGA	p.W523*		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	528	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						AACGATCCTTCCAGGTCAGTT	0.428													4	6					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6690229	6690229	+	Silent	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:6690229A>G	uc001qpo.2	-	33	5054	c.4890T>C	c.(4888-4890)CCT>CCC	p.P1630P	CHD4_uc001qpn.2_Silent_p.P1623P|CHD4_uc001qpp.2_Silent_p.P1655P|uc001qpq.1_Intron	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1630	Required for interaction with PCNT.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CTGTCTCCATAGGTTCCTCTG	0.358													3	176					0	0	1	0	0
COPS7A	50813	broad.mit.edu	37	12	6839855	6839855	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:6839855C>T	uc001qqj.2	+	7	896	c.657C>T	c.(655-657)ACC>ACT	p.T219T	COPS7A_uc009zex.2_RNA|COPS7A_uc001qqk.2_Intron|COPS7A_uc001qql.2_RNA|COPS7A_uc001qqh.2_Silent_p.T219T|COPS7A_uc001qqi.2_Silent_p.T219T|COPS7A_uc001qqm.2_RNA|COPS7A_uc001qqn.3_Silent_p.T219T|COPS7A_uc001qqo.2_Silent_p.T219T	NM_001164094	NP_001157566	Q9UBW8	CSN7A_HUMAN	COP9 complex subunit 7a	219	Potential.				cullin deneddylation	cytoplasm|signalosome				ovary(1)	1						TTAAAAAAACCATTAAAGTTA	0.547													15	15					0	0	1	0	0
LRRC23	10233	broad.mit.edu	37	12	7015068	7015068	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:7015068G>A	uc001qrt.3	+	3	578	c.186G>A	c.(184-186)AAG>AAA	p.K62K	LRRC23_uc001qrn.1_Silent_p.K62K|LRRC23_uc009zfg.2_Intron|LRRC23_uc001qrp.2_Silent_p.K62K|LRRC23_uc001qrq.2_Silent_p.K62K|LRRC23_uc001qrr.2_Intron|LRRC23_uc001qrs.2_Intron|LRRC23_uc009zfh.2_Silent_p.K62K	NM_001135217	NP_001128689	Q53EV4	LRC23_HUMAN	leucine rich repeat containing 23 isoform a	62										ovary(1)	1						TGCTCTGTAAGACAGGCAATG	0.557													35	51					0	0	1	0	0
LRRC23	10233	broad.mit.edu	37	12	7021922	7021922	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:7021922C>T	uc001qrt.3	+	7	1179	c.787C>T	c.(787-789)CTG>TTG	p.L263L	LRRC23_uc001qrp.2_Silent_p.L263L|LRRC23_uc001qrq.2_Intron|LRRC23_uc001qrr.2_Silent_p.L212L|LRRC23_uc001qrs.2_Intron|LRRC23_uc009zfh.2_Intron|ENO2_uc001qru.1_5'Flank|ENO2_uc009zfi.1_5'Flank|ENO2_uc010sfq.1_5'Flank|ENO2_uc001qrv.1_5'Flank	NM_001135217	NP_001128689	Q53EV4	LRC23_HUMAN	leucine rich repeat containing 23 isoform a	263	LRR 8.									ovary(1)	1						CCTGGGGGAGCTGGCCAAGCT	0.602													3	94					0	0	1	0	0
PHB2	11331	broad.mit.edu	37	12	7079364	7079364	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:7079364G>A	uc001qsd.2	-	2	417	c.207C>T	c.(205-207)CAC>CAT	p.H69H	PHB2_uc010sft.1_Silent_p.H69H|PHB2_uc010sfu.1_Silent_p.H69H|EMG1_uc009zfo.2_5'Flank|EMG1_uc001qsh.3_5'Flank|EMG1_uc010sfv.1_5'Flank	NM_001144831	NP_001138303	Q99623	PHB2_HUMAN	prohibitin 2 isoform 1	69					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial inner membrane|nucleus	estrogen receptor binding|receptor activity			ovary(2)|pancreas(1)	3						ATTACCTGAAGTGAAGGCCCT	0.597													12	161					0	0	1	0	0
C1R	715	broad.mit.edu	37	12	7244122	7244123	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:7244122_7244123CC>TT	uc010sfy.1	-	2	215_216	c.156_157GG>AA	c.(154-159)ACGGGA>ACAAGA	p.G53R	C1R_uc010sfz.1_Missense_Mutation_p.G67R|C1R_uc010sga.1_Missense_Mutation_p.G53R	NM_001733	NP_001724	P00736	C1R_HUMAN	complement component 1, r subcomponent	53	CUB 1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity				0					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ACCCTGTATCCCGTGGGGACTG	0.535													5	8					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7293967	7293967	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:7293967G>A	uc001qsr.2	+	9	1731	c.1453G>A	c.(1453-1455)GAG>AAG	p.E485K	CLSTN3_uc001qss.2_Missense_Mutation_p.E497K	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	485	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1						ACCCCGAAGGGAGCCTGCTCT	0.567											OREG0021650	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	99	100					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7647994	7647994	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:7647994C>T	uc001qsz.3	-	6	1231	c.1103G>A	c.(1102-1104)GGA>GAA	p.G368E	CD163_uc001qta.3_Missense_Mutation_p.G368E|CD163_uc009zfw.2_Missense_Mutation_p.G368E	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	368	Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						CAGATCTGATCCATCTGCAAA	0.438													17	23					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7651689	7651689	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:7651689C>T	uc001qsz.3	-	4	681	c.553G>A	c.(553-555)GAT>AAT	p.D185N	CD163_uc001qta.3_Missense_Mutation_p.D185N|CD163_uc009zfw.2_Missense_Mutation_p.D185N	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	185	SRCR 2.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						AAGTTATCATCACACACTGTT	0.428													55	130					0	0	1	0	0
GDF3	9573	broad.mit.edu	37	12	7842962	7842962	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:7842962C>T	uc001qte.2	-	2	643	c.607G>A	c.(607-609)GAG>AAG	p.E203K		NM_020634	NP_065685	Q9NR23	GDF3_HUMAN	growth differentiation factor 3 precursor	203					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity	p.E203K(1)		skin(3)|ovary(1)|lung(1)|central_nervous_system(1)	6						ACCAGTATCTCCAGGAATAAC	0.502													31	51					0	0	1	0	0
C3AR1	719	broad.mit.edu	37	12	8212549	8212549	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:8212549G>A	uc001qtv.1	-	2	325	c.233C>T	c.(232-234)TCG>TTG	p.S78L		NM_004054	NP_004045	Q16581	C3AR_HUMAN	complement component 3a receptor 1	78	Helical; Name=2; (Potential).				blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)	1				Kidney(36;0.0893)		GTGAGCCAGCGAGAAGGGCAA	0.577													11	10					0	0	1	0	0
CLEC4D	338339	broad.mit.edu	37	12	8671757	8671757	+	Splice_Site	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:8671757G>A	uc001qun.2	+	4	577	c.384_splice	c.e4+1	p.Q128_splice		NM_080387	NP_525126	Q8WXI8	CLC4D_HUMAN	C-type lectin domain family 4, member D						innate immune response	integral to membrane	sugar binding				0	Lung SC(5;0.184)					AGCTGAGCAGGTGTGTTGGGA	0.403													13	32					0	0	1	0	0
A2ML1	144568	broad.mit.edu	37	12	9009896	9009896	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:9009896G>A	uc001quz.3	+	24	3083	c.2985G>A	c.(2983-2985)ACG>ACA	p.T995T	A2ML1_uc001qva.1_Silent_p.T575T|A2ML1_uc010sgm.1_Silent_p.T495T	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	839						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						GGCTGCTGACGGAGGAGATCA	0.522													77	116					0	0	1	0	0
A2M	2	broad.mit.edu	37	12	9248140	9248140	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:9248140G>A	uc001qvk.1	-	16	2121	c.2008C>T	c.(2008-2010)CTA>TTA	p.L670L	A2M_uc009zgk.1_Silent_p.L520L	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	670					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	TTTACCTCTAGGAAGCTGTAC	0.353													14	7					0	0	1	0	0
KLRC1	3821	broad.mit.edu	37	12	10603136	10603136	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:10603136C>T	uc001qyl.2	-	3	394	c.230G>A	c.(229-231)GGA>GAA	p.G77E	KLRC1_uc009zhm.1_Missense_Mutation_p.G77E|KLRC1_uc001qym.2_Missense_Mutation_p.G77E|KLRC1_uc001qyn.2_Missense_Mutation_p.G77E|KLRC1_uc001qyo.2_Missense_Mutation_p.G77E	NM_002259	NP_002250	P26715	NKG2A_HUMAN	killer cell lectin-like receptor subfamily C,	77	Helical; Signal-anchor for type II membrane protein; (Potential).				cell surface receptor linked signaling pathway|regulation of immune response	integral to plasma membrane	sugar binding|transmembrane receptor activity				0						ACAGATAATTCCCAGGATCCC	0.418													38	65					0	0	1	0	0
TAS2R46	259292	broad.mit.edu	37	12	11214245	11214245	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:11214245G>A	uc001qzp.1	-	1	649	c.649C>T	c.(649-651)CAA>TAA	p.Q217*	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176887	NP_795368	P59540	T2R46_HUMAN	taste receptor, type 2, member 46	217	Cytoplasmic (Potential).				sensory perception of taste	cilium membrane|integral to membrane	G-protein coupled receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)		CTGGGATCTTGAGATCCTTTG	0.408													19	34					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13715923	13715923	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:13715923C>T	uc001rbt.2	-	13	4428	c.4249G>A	c.(4249-4251)GCC>ACC	p.A1417T		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1417	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCCGGCCTGGCTTTCGACGCC	0.607													11	12					0	0	1	0	0
ATF7IP	55729	broad.mit.edu	37	12	14577751	14577751	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:14577751C>T	uc001rbw.2	+	2	1060	c.902C>T	c.(901-903)CCT>CTT	p.P301L	ATF7IP_uc010shs.1_Missense_Mutation_p.P301L|ATF7IP_uc001rbu.2_Missense_Mutation_p.P301L|ATF7IP_uc001rbv.1_Missense_Mutation_p.P301L|ATF7IP_uc001rbx.2_Missense_Mutation_p.P301L|ATF7IP_uc010sht.1_Missense_Mutation_p.P301L|ATF7IP_uc001rby.3_Missense_Mutation_p.P301L|ATF7IP_uc001rbz.1_Missense_Mutation_p.P301L|ATF7IP_uc001rca.2_Missense_Mutation_p.P301L|ATF7IP_uc001rcb.2_5'Flank	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	301					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						GAACCAGTTCCTGAAATTGAC	0.383													18	38					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14798250	14798250	+	Splice_Site	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:14798250C>T	uc001rcd.2	-	16	1848	c.1711_splice	c.e16-1	p.E571_splice		NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor						intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						TTAAAACTTCCTGAATAGGAA	0.333													22	21					0	0	1	0	0
C12orf60	144608	broad.mit.edu	37	12	14976084	14976084	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:14976084C>G	uc001rcj.3	+	2	419	c.215C>G	c.(214-216)TCT>TGT	p.S72C		NM_175874	NP_787070	Q5U649	CL060_HUMAN	hypothetical protein LOC144608	72										ovary(1)|central_nervous_system(1)	2						GAGATGCAATCTGTAGTGGAT	0.368													3	88					0	0	1	0	0
DERA	51071	broad.mit.edu	37	12	16109925	16109925	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:16109925G>A	uc001rde.2	+	2	219	c.87G>A	c.(85-87)GCG>GCA	p.A29A	DERA_uc010shx.1_5'UTR	NM_015954	NP_057038	Q9Y315	DEOC_HUMAN	deoxyribose-phosphate aldolase-like	29					deoxyribonucleoside catabolic process|deoxyribonucleotide catabolic process	cytoplasm	deoxyribose-phosphate aldolase activity|protein binding				0		Hepatocellular(102;0.121)				TGAGGCGTGCGGAACAAATCC	0.443													6	41					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21028237	21028237	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:21028237G>A	uc001rek.2	+	8	922	c.796G>A	c.(796-798)GGA>AGA	p.G266R	SLCO1B3_uc001rel.2_Missense_Mutation_p.G266R|SLCO1B3_uc010sil.1_Missense_Mutation_p.G266R|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Missense_Mutation_p.G91R	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	266	Helical; Name=6; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					CCTTGTGTCTGGACTATTTTC	0.373													28	44					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26592111	26592111	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:26592111G>A	uc001rhg.2	-	47	7009	c.6592C>T	c.(6592-6594)CAG>TAG	p.Q2198*	ITPR2_uc009zjg.1_Nonsense_Mutation_p.Q349*	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	2198	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					TCTGTTTGCTGGAAAAAGTCA	0.378													28	69					0	0	1	0	0
C12orf35	55196	broad.mit.edu	37	12	32140250	32140250	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:32140250G>A	uc001rks.2	+	5	5494	c.5080G>A	c.(5080-5082)GAG>AAG	p.E1694K	C12orf35_uc001rkt.2_RNA	NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	1694										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			AGACAGCCAAGAGAGAGGTAA	0.294													12	15					0	0	1	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48137379	48137379	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:48137379C>T	uc009zkp.2	-	17	2073	c.1633G>A	c.(1633-1635)GCA>ACA	p.A545T	RAPGEF3_uc001rpw.2_5'Flank|RAPGEF3_uc001rpx.2_Missense_Mutation_p.A2T|RAPGEF3_uc010sln.1_Intron|RAPGEF3_uc001rpy.2_RNA|RAPGEF3_uc009zkq.2_Missense_Mutation_p.A545T|RAPGEF3_uc001rpz.3_Missense_Mutation_p.A587T	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	545					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		GCCAACGCTGCCATCACCTCT	0.607													30	40					0	0	1	0	0
FMNL3	91010	broad.mit.edu	37	12	50045894	50045894	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:50045894G>A	uc001ruv.1	-	14	1659	c.1425C>T	c.(1423-1425)GTC>GTT	p.V475V	FMNL3_uc001ruw.1_Silent_p.V424V|FMNL3_uc001rut.1_Silent_p.V41V|FMNL3_uc001ruu.1_Silent_p.V325V	NM_175736	NP_783863	Q8IVF7	FMNL3_HUMAN	formin-like 3 isoform 1	475					actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(2)|pancreas(2)	4						CCAGGCCCCGGACATTTGGCT	0.592													5	6					0	0	1	0	0
SCN8A	6334	broad.mit.edu	37	12	52162882	52162882	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:52162882C>T	uc001ryw.2	+	17	3313	c.3135C>T	c.(3133-3135)ATC>ATT	p.I1045I	SCN8A_uc010snl.1_Silent_p.I910I	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1045					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CCAACTGTATCGCCAATCACA	0.522													7	6					0	0	1	0	0
KRT85	3891	broad.mit.edu	37	12	52756677	52756677	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:52756677G>A	uc001sag.2	-	6	1158	c.1038C>T	c.(1036-1038)ATC>ATT	p.I346I		NM_002283	NP_002274	P78386	KRT85_HUMAN	keratin 85	346	Rod.|Coil 2.				epidermis development	keratin filament	protein binding|structural molecule activity			ovary(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TCAGCCTCTGGATCATGCGGT	0.587													47	77					0	0	1	0	0
KRT82	3888	broad.mit.edu	37	12	52789550	52789550	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:52789550C>T	uc001sai.1	-	8	1429	c.1314G>A	c.(1312-1314)GTG>GTA	p.V438V		NM_033033	NP_149022	Q9NSB4	KRT82_HUMAN	keratin 82	438	Tail.					keratin filament	protein binding|structural constituent of epidermis			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.193)		TACAGATATTCACGGGCCCGA	0.552													13	17					0	0	1	0	0
SOAT2	8435	broad.mit.edu	37	12	53516968	53516968	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:53516968C>T	uc001sbv.2	+	13	1428	c.1340C>T	c.(1339-1341)CCC>CTC	p.P447L	SOAT2_uc009zms.2_RNA	NM_003578	NP_003569	O75908	SOAT2_HUMAN	acyl-CoA:cholesterol acyltransferase 2	447	Helical; (Potential).				cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			ovary(1)	1						TTCTTCTATCCCGTCATGCTG	0.587													21	52					0	0	1	0	0
AMHR2	269	broad.mit.edu	37	12	53818111	53818111	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:53818111C>T	uc001scx.1	+	2	167	c.89C>T	c.(88-90)CCT>CTT	p.P30L	AMHR2_uc009zmy.1_Missense_Mutation_p.P30L	NM_020547	NP_065434	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II isoform	30	Extracellular (Potential).				Mullerian duct regression		ATP binding|hormone binding|metal ion binding			ovary(1)|skin(1)	2					Adenosine triphosphate(DB00171)	TTTGAGGCCCCTGGAGTGCGG	0.572									Persistant_Mullerian_Duct_Syndrome_(type_I_and_II)				22	22					0	0	1	0	0
NFE2	4778	broad.mit.edu	37	12	54686238	54686238	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:54686238C>T	uc009znk.2	-	2	1552	c.1042G>A	c.(1042-1044)GAA>AAA	p.E348K	NFE2_uc001sfq.2_Missense_Mutation_p.E348K|NFE2_uc001sfr.3_Missense_Mutation_p.E348K|NFE2_uc009znl.2_Missense_Mutation_p.E348K	NM_006163	NP_006154	Q16621	NFE2_HUMAN	nuclear factor, erythroid derived 2 isoform 1	348					blood circulation|blood coagulation|multicellular organismal development|nucleosome disassembly|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	actin cytoskeleton|cytoplasm|PML body	protein dimerization activity|protein N-terminus binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|WW domain binding				0						GCGTACTCTTCAGGAGAGTAG	0.602													43	65					0	0	1	0	0
OR6C2	341416	broad.mit.edu	37	12	55846192	55846192	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:55846192C>T	uc001sgz.1	+	1	195	c.195C>T	c.(193-195)TCC>TCT	p.S65S		NM_054105	NP_473446	Q9NZP2	OR6C2_HUMAN	olfactory receptor, family 6, subfamily C,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GAAATTTTTCCTTCTTAGAAG	0.398													10	22					0	0	1	0	0
ZC3H10	84872	broad.mit.edu	37	12	56515173	56515173	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:56515173G>A	uc001sjp.1	+	3	1016	c.827G>A	c.(826-828)CGC>CAC	p.R276H		NM_032786	NP_116175	Q96K80	ZC3HA_HUMAN	zinc finger CCCH-type containing 10	276	Potential.						nucleic acid binding|zinc ion binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.12)			GCTCAGTTCCGCAATCAGGCC	0.537													3	66					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57570838	57570838	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:57570838G>A	uc001snd.2	+	25	4472	c.4006G>A	c.(4006-4008)GAG>AAG	p.E1336K		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1336	LDL-receptor class B 8.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GACTAGTTTCGAGGTGGTGAT	0.557													54	99					0	0	1	0	0
KIF5A	3798	broad.mit.edu	37	12	57966029	57966029	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:57966029G>A	uc001sor.1	+	14	1756	c.1548G>A	c.(1546-1548)GTG>GTA	p.V516V	KIF5A_uc010srr.1_Silent_p.V427V	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	516					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						AGCTTCTGGTGGATGAGCTGT	0.567													7	3					0	0	1	0	0
GEFT	115557	broad.mit.edu	37	12	58010182	58010182	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:58010182G>A	uc001spb.2	+	14	1996	c.1536G>A	c.(1534-1536)CAG>CAA	p.Q512Q	GEFT_uc009zpy.2_Silent_p.Q551Q|GEFT_uc001spa.2_Silent_p.Q406Q|uc001spc.2_Intron|GEFT_uc001spd.2_Silent_p.Q217Q	NM_182947	NP_891992	Q86VW2	ARHGP_HUMAN	RhoA/RAC/CDC42 exchange factor isoform 1	512					regulation of Rho protein signal transduction	cytosol|plasma membrane|sarcomere	Rho guanyl-nucleotide exchange factor activity				0	Melanoma(17;0.122)					ATCAGGCCCAGGGCAGCACAC	0.602													15	43					0	0	1	0	0
SRGAP1	57522	broad.mit.edu	37	12	64485121	64485121	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:64485121C>T	uc010ssp.1	+	12	1558	c.1502C>T	c.(1501-1503)ACT>ATT	p.T501I	SRGAP1_uc001srv.2_Intron	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	501					axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		CAGTATAATACTAAGTTGTTT	0.483													21	33					0	0	1	0	0
NUP107	57122	broad.mit.edu	37	12	69120344	69120344	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:69120344C>T	uc001suf.2	+	19	1757	c.1642C>T	c.(1642-1644)CGC>TGC	p.R548C	NUP107_uc001sug.2_Missense_Mutation_p.R395C|NUP107_uc010stj.1_Missense_Mutation_p.R519C	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	548					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			ACACCTGCTTCGCTTTATGAC	0.378													29	38					0	0	1	0	0
SLC35E3	55508	broad.mit.edu	37	12	69140394	69140394	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:69140394C>T	uc001suh.2	+	1	459	c.237C>T	c.(235-237)CTC>CTT	p.L79L		NM_018656	NP_061126	Q7Z769	S35E3_HUMAN	solute carrier family 35, member E2	79	Poly-Leu.|Helical; (Potential).					integral to membrane					0	Breast(13;2.31e-06)|Renal(347;0.0684)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00372)			GGCTCCTCCTCCTGGCCCTCA	0.577													24	35					0	0	1	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72009043	72009043	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:72009043C>T	uc001swo.2	-	28	5557	c.5198G>A	c.(5197-5199)GGG>GAG	p.G1733E		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	1733					RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						ATCAAAATTCCCTTTACATAA	0.358													26	37					0	0	1	0	0
TPH2	121278	broad.mit.edu	37	12	72416259	72416259	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:72416259C>T	uc009zrw.1	+	9	1290	c.1149C>T	c.(1147-1149)TCC>TCT	p.S383S	TPH2_uc001swy.2_Silent_p.S293S	NM_173353	NP_775489	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	383					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			ovary(2)|central_nervous_system(1)|skin(1)	4					L-Tryptophan(DB00150)	TCCTTTCCTCCATTGGAGAAT	0.423													14	18					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	73046189	73046189	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:73046189C>T	uc001sxa.2	+	16	2658	c.2628C>T	c.(2626-2628)TTC>TTT	p.F876F		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	876	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						GGATGAAATTCCATTCCACCA	0.383													8	22					0	0	1	0	0
E2F7	144455	broad.mit.edu	37	12	77423987	77423987	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:77423987G>A	uc001sym.3	-	10	1744	c.1508C>T	c.(1507-1509)TCT>TTT	p.S503F	E2F7_uc009zse.2_5'UTR	NM_203394	NP_976328	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	503					cell cycle	transcription factor complex	DNA binding|identical protein binding			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3						CTGAGCAACAGAAAATACTGG	0.522													51	64					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85449926	85449926	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:85449926A>T	uc001tac.2	+	8	1466	c.1355A>T	c.(1354-1356)GAT>GTT	p.D452V	LRRIQ1_uc001tab.1_Missense_Mutation_p.D452V|LRRIQ1_uc001taa.1_Missense_Mutation_p.D427V	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	452										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		GAAAATGTAGATAGACAGACT	0.299													15	14					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85450579	85450579	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:85450579A>G	uc001tac.2	+	8	2119	c.2008A>G	c.(2008-2010)AAA>GAA	p.K670E	LRRIQ1_uc001tab.1_Missense_Mutation_p.K670E|LRRIQ1_uc001taa.1_Missense_Mutation_p.K645E	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	670										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TATAGAAGGCAAAAGAAATGA	0.363													7	24					0	0	1	0	0
KITLG	4254	broad.mit.edu	37	12	88939578	88939578	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:88939578C>T	uc001tav.2	-	2	263	c.80G>A	c.(79-81)GGG>GAG	p.G27E	KITLG_uc001taw.2_Missense_Mutation_p.G27E	NM_000899	NP_000890	P21583	SCF_HUMAN	KIT ligand isoform b precursor	27	Extracellular (Potential).				cell adhesion|cell proliferation|hemopoiesis|male gonad development|positive regulation of DNA replication|signal transduction	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	growth factor activity|identical protein binding|stem cell factor receptor binding			ovary(1)	1						CCTGCAGATCCCTTCAGTTTT	0.378									Testicular_Cancer_Familial_Clustering_of				7	15					0	0	1	0	0
EPYC	1833	broad.mit.edu	37	12	91372011	91372011	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:91372011C>T	uc001tbk.2	-	3	287	c.194G>A	c.(193-195)GGG>GAG	p.G65E		NM_004950	NP_004941	Q99645	EPYC_HUMAN	dermatan sulfate proteoglycan 3 precursor	65					female pregnancy	proteinaceous extracellular matrix	glycosaminoglycan binding			skin(1)	1						CTCTCTGTTCCCTGAAGGCAT	0.483											OREG0022019	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	10					0	0	1	0	0
CCDC38	120935	broad.mit.edu	37	12	96300182	96300182	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:96300182C>T	uc001tek.1	-	5	586	c.352G>A	c.(352-354)GAC>AAC	p.D118N		NM_182496	NP_872302	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38	118										skin(1)	1						AGAAACCTGTCTCTCTGGTCA	0.353													20	23					0	0	1	0	0
SLC17A8	246213	broad.mit.edu	37	12	100813710	100813710	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:100813710C>T	uc010svi.1	+	12	1856	c.1543C>T	c.(1543-1545)CTC>TTC	p.L515F	SLC17A8_uc009ztx.2_Missense_Mutation_p.L465F	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	515	Cytoplasmic (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						CCCAGAGAATCTCTCTGAGGA	0.468													14	29					0	0	1	0	0
RFX4	5992	broad.mit.edu	37	12	107080872	107080872	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:107080872G>A	uc001tlr.2	+	6	654	c.588G>A	c.(586-588)GAG>GAA	p.E196E	RFX4_uc010swv.1_RNA|RFX4_uc001tls.2_Silent_p.E205E|RFX4_uc001tlt.2_Silent_p.E205E|RFX4_uc001tlv.2_Silent_p.E102E|uc001tlu.3_5'Flank	NM_213594	NP_998759	Q33E94	RFX4_HUMAN	regulatory factor X4 isoform c	196					transcription, DNA-dependent	nucleus	DNA binding			upper_aerodigestive_tract(1)	1						TGCCTGAGGAGAAGGTAACTA	0.348													42	47					0	0	1	0	0
SVOP	55530	broad.mit.edu	37	12	109306379	109306379	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:109306379G>A	uc010sxh.1	-	15	1751	c.1579C>T	c.(1579-1581)CAG>TAG	p.Q527*		NM_018711	NP_061181	Q8N4V2	SVOP_HUMAN	SV2 related protein	527	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	ion transmembrane transporter activity				0						ACCATCTCCTGGCCCCACTCC	0.612													99	164					0	0	1	0	0
SVOP	55530	broad.mit.edu	37	12	109313543	109313543	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:109313543C>T	uc010sxh.1	-	12	1348	c.1176G>A	c.(1174-1176)TGG>TGA	p.W392*		NM_018711	NP_061181	Q8N4V2	SVOP_HUMAN	SV2 related protein	392	Helical; (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	ion transmembrane transporter activity				0						GGTCAATAATCCACAGAGTCA	0.378													3	9					0	0	1	0	0
UBE3B	89910	broad.mit.edu	37	12	109940943	109940943	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:109940943C>T	uc001top.2	+	14	2001	c.1398C>T	c.(1396-1398)CTC>CTT	p.L466L	UBE3B_uc001toq.2_Silent_p.L466L|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Silent_p.L466L	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	466					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						TCTGTGTCCTCTACCAGACCT	0.522													29	51					0	0	1	0	0
ANKRD13A	88455	broad.mit.edu	37	12	110451049	110451049	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:110451049C>A	uc001tpx.2	+	3	608	c.349C>A	c.(349-351)CTC>ATC	p.L117I	ANKRD13A_uc009zvl.1_RNA|ANKRD13A_uc009zvm.1_Missense_Mutation_p.L117I|ANKRD13A_uc010sxw.1_Missense_Mutation_p.L117I	NM_033121	NP_149112	Q8IZ07	AN13A_HUMAN	ankyrin repeat domain 13	117											0						CCAAAAAATTCTCGAGGTATC	0.468													23	29					1.7367e-05	1.74673e-05	1	1	0
CUX2	23316	broad.mit.edu	37	12	111746297	111746297	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:111746297C>T	uc001tsa.1	+	14	1378	c.1225C>T	c.(1225-1227)CTT>TTT	p.L409F		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	409						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GCAGAAATTCCTTCTGGAGAA	0.617													5	6					0	0	1	0	0
MED13L	23389	broad.mit.edu	37	12	116428926	116428926	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:116428926G>A	uc001tvw.2	-	17	3888	c.3833C>T	c.(3832-3834)GCG>GTG	p.A1278V		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1278					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		CTGCTCCAACGCATTAAAGCA	0.493													33	66					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	117914376	117914376	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:117914376C>T	uc001two.2	-	17	2443	c.2388G>A	c.(2386-2388)CAG>CAA	p.Q796Q		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	825	Protein kinase.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCCAGCCATTCTGGATGCGCA	0.587													6	9					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	117962701	117962701	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:117962701G>A	uc001two.2	-	14	2143	c.2088C>T	c.(2086-2088)TTC>TTT	p.F696F		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	725	Protein kinase.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGGCACCCATGAAAAGCACCA	0.527													22	24					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120150480	120150480	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:120150480C>T	uc001txi.1	-	35	4527	c.4474G>A	c.(4474-4476)GAA>AAA	p.E1492K	CIT_uc001txh.1_Missense_Mutation_p.E1011K|CIT_uc001txj.1_Missense_Mutation_p.E1534K	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1492	PH.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		AGCTCAAATTCTTCCACCGGC	0.363													33	37					0	0	1	0	0
PXN	5829	broad.mit.edu	37	12	120652670	120652670	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:120652670G>A	uc001txt.2	-	9	1367	c.1236C>T	c.(1234-1236)CTC>CTT	p.L412L	PXN_uc001txu.2_Silent_p.L224L|PXN_uc001txv.2_Silent_p.L293L|PXN_uc001txx.2_Silent_p.L245L|PXN_uc001txy.2_Silent_p.L378L|PXN_uc001txz.2_RNA	NM_001080855	NP_001074324	P49023	PAXI_HUMAN	paxillin isoform 1	412	LIM zinc-binding 1.				cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			ovary(1)|breast(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCGGGGAGAAGAGGTTGTGGT	0.617													38	51					0	0	1	0	0
COQ5	84274	broad.mit.edu	37	12	120941789	120941789	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:120941789C>T	uc001tyn.2	-	6	886	c.866G>A	c.(865-867)CGA>CAA	p.R289Q	COQ5_uc001tyo.2_Missense_Mutation_p.R208Q|COQ5_uc010szj.1_Missense_Mutation_p.R215Q	NM_032314	NP_115690	Q5HYK3	COQ5_HUMAN	coenzyme Q5 homolog, methyltransferase	289					ubiquinone biosynthetic process	mitochondrion	methyltransferase activity			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CGGAAACCTTCGGATACTCTC	0.458													19	131					0	0	1	0	0
MLXIP	22877	broad.mit.edu	37	12	122614161	122614161	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:122614161C>T	uc001ubq.2	+	5	723	c.723C>T	c.(721-723)CTC>CTT	p.L241L	MLXIP_uc001ubr.2_5'UTR|MLXIP_uc001ubs.1_5'Flank	NM_014938	NP_055753	Q9HAP2	MLXIP_HUMAN	MLX interacting protein	241	Required for cytoplasmic localization.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial outer membrane|nucleus	DNA binding			ovary(2)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;0.0659)		OV - Ovarian serous cystadenocarcinoma(86;0.000599)|Epithelial(86;0.00102)|BRCA - Breast invasive adenocarcinoma(302;0.233)		ATGAGGACCTCTCCAGCCTGG	0.602													4	15					0	0	1	0	0
ABCB9	23457	broad.mit.edu	37	12	123433228	123433228	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:123433228G>A	uc001udm.3	-	5	1306	c.996C>T	c.(994-996)ACC>ACT	p.T332T	ABCB9_uc009zxr.2_Intron|ABCB9_uc001udo.3_Silent_p.T332T|ABCB9_uc010taj.1_Silent_p.T332T|ABCB9_uc001udp.2_Silent_p.T332T|ABCB9_uc001udq.2_Silent_p.T114T|ABCB9_uc001udr.2_Silent_p.T332T	NM_019625	NP_062571	Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	332	ABC transmembrane type-1.|Helical; (Potential).				positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		AGCCCATGAAGGTGACCAAGG	0.537													21	26					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124333348	124333348	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:124333348C>T	uc001uft.3	+	33	5692	c.5667C>T	c.(5665-5667)ATC>ATT	p.I1889I		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1889	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TTAATCGAATCGATGCTTCTG	0.532													7	12					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124341761	124341761	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:124341761G>A	uc001uft.3	+	36	6268	c.6243G>A	c.(6241-6243)CTG>CTA	p.L2081L		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2081	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AGCAGGTCCTGGAGGAGAACG	0.527													23	39					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124383315	124383315	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:124383315C>T	uc001uft.3	+	55	9265	c.9240C>T	c.(9238-9240)GCC>GCT	p.A3080A		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3080	Potential.|Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AGAAGTCCGCCGCCTGCGAGG	0.642													11	15					0	0	1	0	0
TUBA3C	7278	broad.mit.edu	37	13	19751628	19751628	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:19751628G>A	uc009zzj.2	-	4	544	c.495C>T	c.(493-495)TCC>TCT	p.S165S		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	165					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		ATTCTAGCTTGGACTTCTTGC	0.577													45	126					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23929371	23929371	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:23929371G>A	uc001uon.2	-	8	1969	c.1380C>T	c.(1378-1380)CTC>CTT	p.L460L	SACS_uc001uoo.2_Silent_p.L313L|SACS_uc001uop.1_Silent_p.L247L|SACS_uc001uoq.1_Silent_p.L313L	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	460					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TGTGAACTGGGAGGCCTGTGC	0.493													18	26					0	0	1	0	0
C1QTNF9	338872	broad.mit.edu	37	13	24892968	24892968	+	Missense_Mutation	SNP	G	A	A	rs149288885	byFrequency	TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:24892968G>A	uc001upj.2	+	3	240	c.179G>A	c.(178-180)CGT>CAT	p.R60H	C1QTNF9_uc001upe.2_RNA	NM_178540	NP_848635	P0C862	C1T9A_HUMAN	C1q and tumor necrosis factor related protein 9	60	Collagen-like 1.					collagen	hormone activity				0		all_cancers(29;3.55e-20)|all_epithelial(30;4.25e-17)|all_lung(29;1.04e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.00565)|Epithelial(112;0.027)|OV - Ovarian serous cystadenocarcinoma(117;0.115)|Lung(94;0.159)		GAACCAGGACGTCCTGGCAGC	0.478													6	230					0	0	1	0	0
CENPJ	55835	broad.mit.edu	37	13	25481291	25481291	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:25481291C>T	uc001upt.3	-	6	1268	c.1015G>A	c.(1015-1017)GAA>AAA	p.E339K	CENPJ_uc010tdf.1_RNA|CENPJ_uc010aae.2_RNA|CENPJ_uc010aaf.2_RNA	NM_018451	NP_060921	Q9HC77	CENPJ_HUMAN	centromere protein J	339					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			ovary(2)	2		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		AAGTAATCTTCAAAGGTCTGT	0.338													5	36					0	0	1	0	0
RXFP2	122042	broad.mit.edu	37	13	32367002	32367002	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:32367002C>T	uc001utt.2	+	16	1634	c.1563C>T	c.(1561-1563)TTC>TTT	p.F521F	RXFP2_uc010aba.2_Silent_p.F480F	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	521	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		TGGAGAAGTTCCTGGTCATTG	0.507													16	21					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32811707	32811707	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:32811707C>T	uc001utx.2	+	44	6498	c.6002C>T	c.(6001-6003)GCC>GTC	p.A2001V	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2001					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CCTCGAAGTGCCACACTGGAC	0.547													14	32					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32972844	32972844	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:32972844G>T	uc001uub.1	+	27	10421	c.10194G>T	c.(10192-10194)CAG>CAT	p.Q3398H		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	3398					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AGAGTTCCCAGGCCAGTACGG	0.393			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			16	37					5.03518e-11	5.13095e-11	1	1	0
SOHLH2	54937	broad.mit.edu	37	13	36748880	36748880	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:36748880G>A	uc001uvj.2	-	7	857	c.768C>T	c.(766-768)ATC>ATT	p.I256I	SOHLH2_uc010tei.1_Silent_p.I333I	NM_017826	NP_060296	Q9NX45	SOLH2_HUMAN	spermatogenesis and oogenesis specific basic	256					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;4.63e-08)|Epithelial(112;2.67e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|BRCA - Breast invasive adenocarcinoma(63;0.00685)|GBM - Glioblastoma multiforme(144;0.0273)		CGGCTGGAGAGATTTTCTCCC	0.373													19	51					0	0	1	0	0
SOHLH2	54937	broad.mit.edu	37	13	36776168	36776168	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:36776168C>T	uc001uvj.2	-	2	200	c.111G>A	c.(109-111)CAG>CAA	p.Q37Q	SOHLH2_uc010tei.1_Silent_p.Q114Q	NM_017826	NP_060296	Q9NX45	SOLH2_HUMAN	spermatogenesis and oogenesis specific basic	37					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;4.63e-08)|Epithelial(112;2.67e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|BRCA - Breast invasive adenocarcinoma(63;0.00685)|GBM - Glioblastoma multiforme(144;0.0273)		CAAATAGTTTCTGTACAGTAT	0.428													23	72					0	0	1	0	0
FAM48A	55578	broad.mit.edu	37	13	37583908	37583908	+	Silent	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:37583908T>C	uc001uwg.2	-	26	2489	c.2241A>G	c.(2239-2241)GCA>GCG	p.A747A	FAM48A_uc010abt.2_Missense_Mutation_p.S714G|FAM48A_uc001uwh.2_Missense_Mutation_p.S714G|FAM48A_uc001uwi.2_Missense_Mutation_p.S713G|FAM48A_uc001uwj.2_Missense_Mutation_p.S714G|FAM48A_uc001uwk.2_Missense_Mutation_p.S792G|FAM48A_uc001uwd.2_Missense_Mutation_p.S200G|FAM48A_uc001uwe.2_Silent_p.A231A|FAM48A_uc001uwf.2_Silent_p.A313A	NM_001014286	NP_001014308	Q8NEM7	FA48A_HUMAN	family with sequence similarity 48, member A	747	Gln-rich.				autophagy|gastrulation	SAGA-type complex	protein binding				0		Lung NSC(96;2.09e-06)|Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.0959)		all cancers(112;6.06e-07)|Epithelial(112;1.87e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00794)|BRCA - Breast invasive adenocarcinoma(63;0.0128)|GBM - Glioblastoma multiforme(144;0.0477)		GTGCTGCTGCTGCTGCCATAG	0.458													16	74					0	0	1	0	0
COG3	83548	broad.mit.edu	37	13	46092966	46092966	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:46092966T>C	uc001vak.2	+	18	2101	c.2000T>C	c.(1999-2001)TTG>TCG	p.L667S	COG3_uc010tfv.1_Missense_Mutation_p.L504S|COG3_uc010aci.2_Missense_Mutation_p.L443S	NM_031431	NP_113619	Q96JB2	COG3_HUMAN	component of golgi transport complex 3	667					ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein glycosylation|protein localization to organelle|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	cis-Golgi network|Golgi cisterna membrane|Golgi transport complex	protein binding|protein transporter activity			breast(1)|skin(1)	2		Lung NSC(96;0.000145)|Breast(56;0.000596)|Prostate(109;0.00438)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000124)		AACAATGCCTTGATAGAGTTC	0.393													53	25					0	0	1	0	0
LRCH1	23143	broad.mit.edu	37	13	47315947	47315947	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:47315947C>T	uc001vbj.2	+	19	2387	c.2151C>T	c.(2149-2151)GTC>GTT	p.V717V	LRCH1_uc001vbk.2_Silent_p.V752V|LRCH1_uc001vbl.3_Intron	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	717										ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		TAGTGCTGGTCTATATCACTT	0.532													90	232					0	0	1	0	0
FNDC3A	22862	broad.mit.edu	37	13	49772339	49772339	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:49772339C>T	uc001vcm.2	+	22	3017	c.2712C>T	c.(2710-2712)TCC>TCT	p.S904S	FNDC3A_uc001vcn.2_Silent_p.S904S|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcq.2_Silent_p.S848S	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	904	Fibronectin type-III 7.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		ATAAACAATCCCTAACAGTGG	0.373													36	81					0	0	1	0	0
LOC220429	220429	broad.mit.edu	37	13	50464741	50464741	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:50464741G>A	uc001vdk.2	+	1	197	c.15G>A	c.(13-15)GGG>GGA	p.G5G		NR_003268				Homo sapiens CTAGE family, member 5 pseudogene, mRNA (cDNA clone IMAGE:5270026).												0						AGGAGCCCGGGGCTACCCCTC	0.617													3	12					0	0	1	0	0
ATP7B	540	broad.mit.edu	37	13	52516637	52516637	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:52516637G>A	uc001vfw.2	-	15	3454	c.3297C>T	c.(3295-3297)GGC>GGT	p.G1099G	ATP7B_uc010adv.2_Silent_p.G669G|ATP7B_uc001vfx.2_Silent_p.G892G|ATP7B_uc001vfy.2_Silent_p.G988G|ATP7B_uc010tgt.1_Silent_p.G1034G|ATP7B_uc010tgu.1_Silent_p.G1051G|ATP7B_uc010tgv.1_Silent_p.G1021G|ATP7B_uc001vfv.2_Silent_p.G371G|ATP7B_uc010tgs.1_Silent_p.G310G	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	1099	Cytoplasmic (Potential).		G -> S (in WD).		ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		CAATTCCACAGCCTGGCACTG	0.577									Wilson_disease				47	99					0	0	1	0	0
ATP7B	540	broad.mit.edu	37	13	52524474	52524474	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:52524474C>T	uc001vfw.2	-	10	2666	c.2509G>A	c.(2509-2511)GGA>AGA	p.G837R	ATP7B_uc010adv.2_Intron|ATP7B_uc001vfx.2_Missense_Mutation_p.G675R|ATP7B_uc001vfy.2_Missense_Mutation_p.G726R|ATP7B_uc010tgt.1_Missense_Mutation_p.G837R|ATP7B_uc010tgu.1_Missense_Mutation_p.G789R|ATP7B_uc010tgv.1_Missense_Mutation_p.G759R|ATP7B_uc001vfv.2_Missense_Mutation_p.G109R|ATP7B_uc010tgs.1_Missense_Mutation_p.G109R	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	837	Cytoplasmic (Potential).			G -> A (in Ref. 8; AAA16173).	ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		GGAAACTTTCCCCCAGGGACC	0.547									Wilson_disease				13	60					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61987604	61987604	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:61987604G>A	uc001vid.3	-	2	992	c.628C>T	c.(628-630)CCT>TCT	p.P210S	PCDH20_uc010thj.1_Missense_Mutation_p.P210S	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	183	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		TGGGAAACAGGGAACTGCGGG	0.522													84	70					0	0	1	0	0
RNF219	79596	broad.mit.edu	37	13	79191252	79191252	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:79191252C>A	uc001vkw.1	-	6	703	c.644G>T	c.(643-645)GGA>GTA	p.G215V	uc001vku.1_RNA|RNF219_uc010afb.1_Missense_Mutation_p.G25V|RNF219_uc010afc.2_Intron	NM_024546	NP_078822	Q5W0B1	RN219_HUMAN	ring finger protein 219	215	Potential.						zinc ion binding			large_intestine(2)	2		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		TGCAAACCTTCCAAACCTACA	0.393													27	19					2.2171e-23	2.27257e-23	1	1	0
DOCK9	23348	broad.mit.edu	37	13	99462528	99462528	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:99462528G>A	uc001vnt.2	-	47	5206	c.5151C>T	c.(5149-5151)CTC>CTT	p.L1717L	DOCK9_uc001vnw.2_Silent_p.L1716L|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Silent_p.L1694L|DOCK9_uc001vnq.2_Silent_p.L266L|DOCK9_uc001vnr.2_Silent_p.L360L|DOCK9_uc010tin.1_Silent_p.L337L|DOCK9_uc001vns.2_Silent_p.L266L|DOCK9_uc010tio.1_Silent_p.L386L|DOCK9_uc010tip.1_Silent_p.L427L|DOCK9_uc001vnu.1_Silent_p.L266L|DOCK9_uc010tiq.1_Silent_p.L672L	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1717	DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					ACTGCTCAAGGAGCTCCATCA	0.522													73	68					0	0	1	0	0
DOCK9	23348	broad.mit.edu	37	13	99575609	99575609	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:99575609C>T	uc001vnt.2	-	5	491	c.436G>A	c.(436-438)GAT>AAT	p.D146N	DOCK9_uc001vnw.2_Missense_Mutation_p.D145N|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Missense_Mutation_p.D146N|DOCK9_uc010tis.1_Missense_Mutation_p.D145N|DOCK9_uc010tit.1_Missense_Mutation_p.D146N|DOCK9_uc010afu.1_5'UTR	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	146					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GGAAGTTTATCCAACTTGACC	0.403													44	91					0	0	1	0	0
TM9SF2	9375	broad.mit.edu	37	13	100211643	100211644	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:100211643_100211644CC>TT	uc001voj.1	+	16	1912_1913	c.1779_1780CC>TT	c.(1777-1782)TTCCTT>TTTTTT	p.L594F	TM9SF2_uc010afz.1_Missense_Mutation_p.L429F	NM_004800	NP_004791	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2 precursor	594	Helical; (Potential).				transport	endosome membrane|integral to plasma membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					GGCGTTCATTCCTTACGAGTGG	0.351													5	52					0	0	1	0	0
ITGBL1	9358	broad.mit.edu	37	13	102344973	102344973	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:102344973G>A	uc001vpb.2	+	8	1273	c.1054G>A	c.(1054-1056)GGA>AGA	p.G352R	ITGBL1_uc010agb.2_Missense_Mutation_p.G303R|ITGBL1_uc001vpc.3_Missense_Mutation_p.G211R	NM_004791	NP_004782	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat	352	VII.|Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			ovary(1)|skin(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CTATCCTCCAGGAGATCGCCG	0.483													24	39					0	0	1	0	0
FAM155A	728215	broad.mit.edu	37	13	107823126	107823126	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:107823126C>T	uc001vql.2	-	3	1612	c.1096G>A	c.(1096-1098)GAA>AAA	p.E366K		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	366						integral to membrane	binding			skin(1)	1						AGAAAGGTTTCATAAAGCCCT	0.423													10	43					0	0	1	0	0
F10	2159	broad.mit.edu	37	13	113798296	113798296	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:113798296G>A	uc001vsx.2	+	6	691	c.634G>A	c.(634-636)GAG>AAG	p.E212K	F10_uc010agq.1_RNA|F10_uc001vsy.2_Missense_Mutation_p.E212K|F10_uc001vsz.2_Missense_Mutation_p.E212K	NM_000504	NP_000495	P00742	FA10_HUMAN	coagulation factor X preproprotein	212					blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			pancreas(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGACCCCACCGAGAACCCCTT	0.627													32	84					0	0	1	0	0
RASA3	22821	broad.mit.edu	37	13	114778680	114778680	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr13:114778680G>A	uc001vui.2	-	15	1581	c.1450C>T	c.(1450-1452)CTG>TTG	p.L484L	RASA3_uc010tkk.1_Silent_p.L452L|RASA3_uc001vuj.2_Silent_p.L101L	NM_007368	NP_031394	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	484	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			lung(3)|skin(1)	4	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			AAGAACCTCAGGAAGATGAAG	0.617													12	30					0	0	1	0	0
POTEG	404785	broad.mit.edu	37	14	19553531	19553531	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:19553531G>A	uc001vuz.1	+	1	167	c.115G>A	c.(115-117)GGC>AGC	p.G39S	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	39										ovary(1)	1						CAGGGGGAGCGGCAAGAGCAA	0.592													5	356					0	0	1	0	0
POTEG	404785	broad.mit.edu	37	14	19553703	19553703	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:19553703G>A	uc001vuz.1	+	1	339	c.287G>A	c.(286-288)AGC>AAC	p.S96N	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	96										ovary(1)	1						ACACTCAGGAGCAAGATGGGC	0.612													19	591					0	0	1	0	0
P704P	641455	broad.mit.edu	37	14	20019934	20019934	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:20019934C>T	uc001vwc.3	-	1	339	c.287G>A	c.(286-288)AGC>AAC	p.S96N	P704P_uc001vwb.3_RNA	NM_001145442	NP_001138914	A6NI47	POTEM_HUMAN	prostate-specific P704P	96											0						GCCCATCTTGCTCCTGAGTGT	0.622													17	215					0	0	1	0	0
OR11H6	122748	broad.mit.edu	37	14	20692709	20692709	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:20692709A>G	uc010tlc.1	+	1	841	c.841A>G	c.(841-843)ACA>GCA	p.T281A		NM_001004480	NP_001004480	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H,	281	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		TGTGAGCCCAACATCAGGGAA	0.453													54	2					0	0	1	0	0
PNP	4860	broad.mit.edu	37	14	20943058	20943058	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:20943058C>T	uc001vxo.3	+	4	554	c.412C>T	c.(412-414)CTA>TTA	p.L138L	PNP_uc010ahn.2_3'UTR|PNP_uc001vxn.3_Silent_p.L9L	NM_000270	NP_000261	P00491	PNPH_HUMAN	nucleoside phosphorylase	138					immune response|inosine catabolic process|interleukin-2 secretion|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinamide riboside catabolic process|positive regulation of alpha-beta T cell differentiation|positive regulation of T cell proliferation|purine base metabolic process|purine nucleotide catabolic process|purine-containing compound salvage|response to drug|urate biosynthetic process	cytoskeleton|cytosol	drug binding|nucleoside binding|phosphate binding|purine base binding|purine-nucleoside phosphorylase activity			ovary(2)	2					Aciclovir(DB00787)|Cladribine(DB00242)|Mercaptopurine(DB01033)	CCATATCAACCTACCTGGTTT	0.483													46	4					0	0	1	0	0
SUPT16H	11198	broad.mit.edu	37	14	21852052	21852052	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:21852052C>A	uc001wao.2	-	1	374	c.35G>T	c.(34-36)CGG>CTG	p.R12L	SUPT16H_uc001wap.2_Missense_Mutation_p.R12L|SUPT16H_uc001waq.1_Missense_Mutation_p.R12L	NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	12					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		CTTCACTCGCCGATAATAAGC	0.567													36	9					4.01344e-20	4.11082e-20	1	1	0
MYH7	4625	broad.mit.edu	37	14	23888421	23888421	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:23888421C>T	uc001wjx.2	-	29	4043	c.3937G>A	c.(3937-3939)GAG>AAG	p.E1313K	MIR208B_hsa-mir-208b|MI0005570_5'Flank	NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1313	Potential.			E -> G (in Ref. 14; CAA27381).	adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TTGAGGTCCTCCAGCTGCTGG	0.597													42	7					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23901907	23901907	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:23901907C>T	uc001wjx.2	-	5	549	c.443G>A	c.(442-444)AGC>AAC	p.S148N		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	148	Myosin head-like.		S -> I (in CMH1).		adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CGGGGCCTCGCTCCTCTTCTT	0.597													118	15					0	0	1	0	0
IPO4	79711	broad.mit.edu	37	14	24652710	24652710	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:24652710G>A	uc001wmv.1	-	21	2204	c.2073C>T	c.(2071-2073)TTC>TTT	p.F691F	IPO4_uc001wmt.1_Silent_p.F169F|IPO4_uc001wmu.2_Silent_p.F353F|IPO4_uc001wmx.1_Silent_p.F555F|IPO4_uc001wmy.1_Silent_p.F555F|IPO4_uc010tnz.1_RNA|IPO4_uc001wmw.1_RNA|IPO4_uc001wmz.1_Silent_p.F691F	NM_024658	NP_078934	Q8TEX9	IPO4_HUMAN	importin 4	691					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1				GBM - Glioblastoma multiforme(265;0.0087)		TGTATGGAAGGAAGGCCACAC	0.587													7	19					0	0	1	0	0
IPO4	79711	broad.mit.edu	37	14	24652714	24652714	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:24652714G>C	uc001wmv.1	-	21	2200	c.2069C>G	c.(2068-2070)GCC>GGC	p.A690G	IPO4_uc001wmt.1_Missense_Mutation_p.A168G|IPO4_uc001wmu.2_Missense_Mutation_p.A352G|IPO4_uc001wmx.1_Missense_Mutation_p.A554G|IPO4_uc001wmy.1_Missense_Mutation_p.A554G|IPO4_uc010tnz.1_RNA|IPO4_uc001wmw.1_RNA|IPO4_uc001wmz.1_Missense_Mutation_p.A690G	NM_024658	NP_078934	Q8TEX9	IPO4_HUMAN	importin 4	690					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1				GBM - Glioblastoma multiforme(265;0.0087)		TGGAAGGAAGGCCACACTACA	0.582													5	20					0	0	1	0	0
TINF2	26277	broad.mit.edu	37	14	24709494	24709494	+	Silent	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:24709494T>C	uc001woa.3	-	7	1446	c.1104A>G	c.(1102-1104)TTA>TTG	p.L368L	TINF2_uc010alm.2_3'UTR|TINF2_uc001wob.3_3'UTR|TINF2_uc010tof.1_Silent_p.L333L|TINF2_uc001woc.3_3'UTR	NM_001099274	NP_001092744	Q9BSI4	TINF2_HUMAN	TERF1 (TRF1)-interacting nuclear factor 2	368					negative regulation of epithelial cell proliferation|negative regulation of protein ADP-ribosylation|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance|protein localization to chromosome, telomeric region|telomere assembly|telomere maintenance via telomere lengthening	nuclear telomere cap complex|nucleoplasm|perinucleolar chromocenter	protein binding|protein binding|telomeric DNA binding				0				GBM - Glioblastoma multiforme(265;0.0185)		TAGGAGGTAATAATGATAGTC	0.498									Ataxia_Pancytopenia_syndrome|Congenital_Dyskeratosis				78	8					0	0	1	0	0
TGM1	7051	broad.mit.edu	37	14	24718553	24718553	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:24718553T>C	uc001wod.2	-	15	2544	c.2420A>G	c.(2419-2421)GAG>GGG	p.E807G	TGM1_uc010tog.1_Missense_Mutation_p.E365G	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	807					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	AGGGATGGTCTCTCCTAAGTG	0.602													54	7					0	0	1	0	0
ADCY4	196883	broad.mit.edu	37	14	24787875	24787875	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:24787875G>A	uc001wov.2	-	24	3072	c.3066C>T	c.(3064-3066)GTC>GTT	p.V1022V	ADCY4_uc001wow.2_Silent_p.V1022V|ADCY4_uc010toh.1_Silent_p.V708V|ADCY4_uc001wox.2_Silent_p.V1022V|ADCY4_uc001woy.2_Silent_p.V1022V	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	1022	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		TTTTGCCAAGGACTCCTGTAC	0.552													64	8					0	0	1	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36064993	36064993	+	Silent	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:36064993T>C	uc001wti.2	-	36	5929	c.5538A>G	c.(5536-5538)GTA>GTG	p.V1846V	RALGAPA1_uc010amp.2_RNA|RALGAPA1_uc001wtj.2_Silent_p.V1846V|RALGAPA1_uc010tpv.1_Silent_p.V1859V|RALGAPA1_uc010tpw.1_Silent_p.V1893V	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1846	Minimal domain that binds to TCF3/E12 (By similarity).|Rap-GAP.				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						TTGTAAGATTTACCTAGAAGT	0.328													10	3					0	0	1	0	0
CLEC14A	161198	broad.mit.edu	37	14	38724753	38724753	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:38724753C>T	uc001wum.1	-	1	822	c.475G>A	c.(475-477)GAG>AAG	p.E159K		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	159	Extracellular (Potential).|C-type lectin.					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		CATCGCATCTCCTTCCAGCCT	0.572													48	4					0	0	1	0	0
RPL13AP3	645683	broad.mit.edu	37	14	56233294	56233294	+	RNA	SNP	A	G	G	rs112834599	by1000genomes	TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:56233294A>G	uc010aos.2	+	1		c.332A>G				NR_004844				Homo sapiens ribosomal protein L13a pseudogene, mRNA (cDNA clone IMAGE:5271409).												0						TGAAGCCTACAAGAAAGTTTG	0.557													5	11					0	0	1	0	0
SYT16	83851	broad.mit.edu	37	14	62547972	62547972	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:62547972G>A	uc001xfu.1	+	4	1611	c.1414G>A	c.(1414-1416)GAG>AAG	p.E472K	SYT16_uc010tsd.1_3'UTR|SYT16_uc010tse.1_Missense_Mutation_p.E30K	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	472										central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		TCTGGTTCTGGAGCCAAGAAG	0.473													12	1					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64464056	64464056	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:64464056C>T	uc001xgm.2	+	25	3420	c.3190C>T	c.(3190-3192)CCC>TCC	p.P1064S	SYNE2_uc001xgl.2_Missense_Mutation_p.P1064S	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1064	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AGGAGGGGATCCCCACAGTGA	0.378													10	3					0	0	1	0	0
MTHFD1	4522	broad.mit.edu	37	14	64882158	64882158	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:64882158C>T	uc001xhb.2	+	5	710	c.323C>T	c.(322-324)TCC>TTC	p.S108F	MTHFD1_uc010aqe.2_Missense_Mutation_p.S144F|MTHFD1_uc010aqf.2_Missense_Mutation_p.S164F	NM_005956	NP_005947	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase 1	108	Methylenetetrahydrofolate dehydrogenase and cyclohydrolase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methylenetetrahydrofolate dehydrogenase|protein binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	TCAGAGAATTCCATTAACACT	0.388													143	15					0	0	1	0	0
KIAA0247	9766	broad.mit.edu	37	14	70171350	70171350	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:70171350C>T	uc001xlk.2	+	4	665	c.349C>T	c.(349-351)CCC>TCC	p.P117S	KIAA0247_uc010aqz.2_Missense_Mutation_p.P92S	NM_014734	NP_055549	Q92537	K0247_HUMAN	hypothetical protein LOC9766 precursor	117	Extracellular (Potential).					integral to membrane				ovary(3)	3				all cancers(60;0.00155)|BRCA - Breast invasive adenocarcinoma(234;0.0164)|OV - Ovarian serous cystadenocarcinoma(108;0.0196)		ACTTGGGGTCCCCACGCTGTC	0.507													8	22					0	0	1	0	0
SMOC1	64093	broad.mit.edu	37	14	70490067	70490067	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:70490067G>A	uc001xls.1	+	11	1447	c.1194G>A	c.(1192-1194)AAG>AAA	p.K398K	SMOC1_uc001xlt.1_Silent_p.K398K	NM_022137	NP_071420	Q9H4F8	SMOC1_HUMAN	secreted modular calcium-binding protein 1	398	EF-hand 2.				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			upper_aerodigestive_tract(1)|pancreas(1)	2				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		CCAAGCCCAAGAAATGTGCCC	0.512													101	10					0	0	1	0	0
TMEM90A	646658	broad.mit.edu	37	14	74876442	74876442	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:74876442C>T	uc001xpx.2	-	2	254	c.6G>A	c.(4-6)GAG>GAA	p.E2E		NM_001105579	NP_001099049	A6NDD5	SYN1L_HUMAN	transmembrane protein 90A	2					response to biotic stimulus	Golgi apparatus|integral to membrane					0				BRCA - Breast invasive adenocarcinoma(234;0.00159)		CACTCAGACTCTCCATGGTTC	0.647													11	20					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	75017886	75017886	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:75017886G>A	uc001xqa.2	-	7	1954	c.1567C>T	c.(1567-1569)CTC>TTC	p.L523F		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	523					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CTGTCCCAGAGGCTGTGGCCA	0.706													31	3					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75264455	75264455	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:75264455C>T	uc001xqj.3	+	5	2579	c.2455C>T	c.(2455-2457)CAA>TAA	p.Q819*	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	624					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GCCAGCATCTCAATTTTATAT	0.537													27	5					0	0	1	0	0
SERPINA6	866	broad.mit.edu	37	14	94780706	94780706	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:94780706C>T	uc001ycv.2	-	2	384	c.280G>A	c.(280-282)GGT>AGT	p.G94S	SERPINA6_uc010auv.2_RNA	NM_001756	NP_001747	P08185	CBG_HUMAN	corticosteroid binding globulin precursor	94					regulation of proteolysis|transport	extracellular space	serine-type endopeptidase inhibitor activity|steroid binding			skin(3)|ovary(1)|central_nervous_system(1)	5		all_cancers(154;0.0482)|all_epithelial(191;0.166)		COAD - Colon adenocarcinoma(157;0.211)	Alclometasone(DB00240)|Beclomethasone(DB00394)|Ciclesonide(DB01410)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Halobetasol Propionate(DB00596)|Medrysone(DB00253)|Mitotane(DB00648)|Paramethasone(DB01384)|Prednisolone(DB00860)|Rimexolone(DB00896)|Triamcinolone(DB00620)	AGGTTGAAACCCAGGCCCTGG	0.537													7	13					0	0	1	0	0
SNORD113-9	767569	broad.mit.edu	37	14	101412008	101412008	+	RNA	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:101412008G>A	uc001yiq.2	+	1		c.23G>A				NR_003237				Homo sapiens small nucleolar RNA, C/D box 113-9 (SNORD113-9), non-coding RNA.												0						GAGTACCCTGGGGTGTCTGAA	0.338													33	9					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102478657	102478657	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:102478657C>T	uc001yks.2	+	34	7028	c.6864C>T	c.(6862-6864)ATC>ATT	p.I2288I	DYNC1H1_uc001ykt.1_5'Flank	NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	2288	AAA 2 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						CCAGGATCATCGACAGCGTGA	0.448													49	7					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102505055	102505055	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:102505055C>T	uc001yks.2	+	59	11240	c.11076C>T	c.(11074-11076)CTC>CTT	p.L3692L		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	3692	AAA 5 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						CACCAGATCTCTGTTCCCGGG	0.453													100	10					0	0	1	0	0
C14orf73	91828	broad.mit.edu	37	14	103574810	103574811	+	Nonsense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:103574810_103574811CC>TT	uc001ymk.2	+	10	2008_2009	c.1932_1933CC>TT	c.(1930-1935)ATCCAG>ATTTAG	p.Q645*		NM_001077594	NP_001071062	Q17RC7	EX3L4_HUMAN	hypothetical protein LOC91828	645											0		Melanoma(154;0.155)	Epithelial(46;0.221)			AAGATGACATCCAGCGGCACCT	0.609													99	135					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105413978	105413978	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:105413978C>T	uc010axc.1	-	7	7930	c.7810G>A	c.(7810-7812)GCC>ACC	p.A2604T	AHNAK2_uc001ypx.2_Missense_Mutation_p.A2504T	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2604						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ACATCGGGGGCTGTCACTTCC	0.627													159	22					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	106691916	106691916	+	RNA	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr14:106691916G>A	uc010tyt.1	-	754		c.20447C>T								Parts of antibodies, mostly variable regions.												0						AGAGTCTCAGGGACCCCCCAG	0.587													87	15					0	0	1	0	0
Unknown	0	broad.mit.edu	37	15	20649568	20649568	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:20649568C>T	uc001ytg.2	-	18	2650	c.1941G>A	c.(1939-1941)GGG>GGA	p.G647G	uc010tyx.1_RNA|uc001yth.3_Silent_p.G647G|uc010tyy.1_Silent_p.G647G					RecName: Full=Putative HERC2-like protein 3;																		TTCCTTCTTTCCCCATCCTGT	0.597													83	160					0	0	1	0	0
C15orf2	23742	broad.mit.edu	37	15	24923989	24923989	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:24923989G>A	uc001ywo.2	+	1	3449	c.2975G>A	c.(2974-2976)GGA>GAA	p.G992E		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	992					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CCTGGCACTGGAGACAGTACC	0.502													33	2					0	0	1	0	0
ACTC1	70	broad.mit.edu	37	15	35083353	35083353	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:35083353C>T	uc001ziu.1	-	6	1195	c.952G>A	c.(952-954)GAA>AAA	p.E318K	uc001zit.1_Intron	NM_005159	NP_005150	P68032	ACTC_HUMAN	cardiac muscle alpha actin 1 proprotein	318					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		GCAGTGATTTCCTTCTGCATA	0.453													166	19					0	0	1	0	0
DISP2	85455	broad.mit.edu	37	15	40657439	40657439	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:40657439G>A	uc001zlk.1	+	6	900	c.811G>A	c.(811-813)GAC>AAC	p.D271N		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	271					smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		GCCCCTGGAGGACAGAAGGCA	0.612													34	2					0	0	1	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42116019	42116019	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:42116019C>T	uc001zok.3	+	30	4277	c.3991C>T	c.(3991-3993)CCG>TCG	p.P1331S	MAPKBP1_uc001zoj.3_Missense_Mutation_p.P1325S|MAPKBP1_uc010bcj.2_Missense_Mutation_p.P832S|MAPKBP1_uc010bci.2_Intron|MAPKBP1_uc010udb.1_Missense_Mutation_p.P1164S|MAPKBP1_uc010bck.2_Missense_Mutation_p.P542S|MAPKBP1_uc010bcl.2_Missense_Mutation_p.P832S	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	1331										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		GCCTGGCTTCCCGGTGGGCCT	0.617													59	6					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43585697	43585697	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:43585697C>T	uc001zrf.1	-	2	148	c.143G>A	c.(142-144)AGC>AAC	p.S48N		NM_052955	NP_443187	Q96PF1	TGM7_HUMAN	transglutaminase 7	48					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)	2		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	GAAGGGTCGGCTGAAGCTCAG	0.622													108	13					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43815682	43815682	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:43815682G>A	uc001zrt.2	+	4	2478	c.2011G>A	c.(2011-2013)GAA>AAA	p.E671K		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	671						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AGATGAGGAGGAAGAGGACGC	0.478													16	5					0	0	1	0	0
SPATA5L1	79029	broad.mit.edu	37	15	45709580	45709580	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:45709580C>T	uc001zve.2	+	6	2060	c.1951C>T	c.(1951-1953)CCA>TCA	p.P651S	SPATA5L1_uc001zvf.2_RNA	NM_024063	NP_076968	Q9BVQ7	SPA5L_HUMAN	spermatogenesis associated 5-like 1	651						cytoplasm	ATP binding|nucleoside-triphosphatase activity			ovary(3)|skin(1)	4		Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;7.31e-17)|GBM - Glioblastoma multiforme(94;6.28e-07)		CATCTATATCCCACCTCCAGA	0.383													15	20					0	0	1	0	0
HDC	3067	broad.mit.edu	37	15	50546388	50546388	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:50546388C>T	uc001zxz.2	-	6	765	c.659G>A	c.(658-660)CGA>CAA	p.R220Q	HDC_uc001zxy.2_5'Flank|HDC_uc010uff.1_Missense_Mutation_p.R220Q|HDC_uc010bet.1_Missense_Mutation_p.R141Q|HDC_uc010beu.1_Missense_Mutation_p.R220Q	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	220					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	AGCTTCCCCTCGGAGTGAGAA	0.488													29	9					0	0	1	0	0
RSL24D1	51187	broad.mit.edu	37	15	55475591	55475591	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:55475591T>C	uc002acn.2	-	5	483	c.340A>G	c.(340-342)AAA>GAA	p.K114E		NM_016304	NP_057388	Q9UHA3	RLP24_HUMAN	ribosomal protein L24-like	114					ribosome biogenesis|translation	nucleolus|ribosome	structural constituent of ribosome			ovary(1)	1						TCTTTATTTTTCTTCAATCTA	0.343													8	3					0	0	1	0	0
PRTG	283659	broad.mit.edu	37	15	55971583	55971583	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:55971583C>T	uc002adg.2	-	7	1082	c.1034G>A	c.(1033-1035)CGA>CAA	p.R345Q		NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	345	Ig-like 4.				multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		ACACACAAATCGAGCAGTGCC	0.393													36	10					0	0	1	0	0
DENND4A	10260	broad.mit.edu	37	15	66021535	66021535	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:66021535C>T	uc002aph.2	-	11	1740	c.1362G>A	c.(1360-1362)CTG>CTA	p.L454L	DENND4A_uc002api.2_Silent_p.L454L|DENND4A_uc002apj.3_Silent_p.L454L|DENND4A_uc010ujj.1_Silent_p.L454L	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	454	DENN.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						CTGCTAAAGCCAGTGGGCAGA	0.423													7	1					0	0	1	0	0
ZWILCH	55055	broad.mit.edu	37	15	66821880	66821880	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:66821880A>T	uc002aqb.2	+	12	1370	c.1124A>T	c.(1123-1125)CAG>CTG	p.Q375L	ZWILCH_uc010bhu.1_Missense_Mutation_p.Q261L|ZWILCH_uc002aqa.2_Missense_Mutation_p.Q261L|ZWILCH_uc010bhv.2_Missense_Mutation_p.Q261L	NM_017975	NP_060445	Q9H900	ZWILC_HUMAN	Zwilch	375					cell division|mitotic cell cycle checkpoint|mitotic prometaphase	condensed chromosome kinetochore|cytosol	protein binding			ovary(1)	1						TTGATCATCCAGAGTCTACAA	0.323													74	8					0	0	1	0	0
NOX5	79400	broad.mit.edu	37	15	69318946	69318946	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:69318946G>A	uc002ars.1	+	2	149	c.129G>A	c.(127-129)GGG>GGA	p.G43G	NOX5_uc002arp.1_Silent_p.G25G|NOX5_uc002arq.1_Silent_p.G25G|NOX5_uc010bid.1_Silent_p.G36G|NOX5_uc002arr.1_Silent_p.G43G|NOX5_uc010bie.1_5'UTR	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	43	Cytoplasmic (Potential).|N-terminal regulatory region; interacts with the C-terminal catalytic region in a calcium-dependent manner.|1 (Potential).|EF-hand 1.				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						GAGAAGATGGGGAGATCAGCC	0.537													35	12					0	0	1	0	0
TLE3	7090	broad.mit.edu	37	15	70346850	70346850	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:70346850C>T	uc002asm.2	-	16	2881	c.1762G>A	c.(1762-1764)GCC>ACC	p.A588T	TLE3_uc002ask.2_Missense_Mutation_p.A515T|TLE3_uc002asl.2_Missense_Mutation_p.A588T|TLE3_uc010ukd.1_Missense_Mutation_p.A578T|TLE3_uc010bik.1_Missense_Mutation_p.A169T|TLE3_uc010bil.1_Missense_Mutation_p.A585T|TLE3_uc002asn.2_Missense_Mutation_p.A576T|TLE3_uc002asp.2_Missense_Mutation_p.A580T|TLE3_uc002aso.2_Missense_Mutation_p.A583T	NM_005078	NP_005069	Q04726	TLE3_HUMAN	transducin-like enhancer protein 3 isoform a	588	WD 3.				organ morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|protein binding			lung(2)	2						CAGACTTTGGCGTCAGGGCTA	0.637													3	51					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73616108	73616108	+	Missense_Mutation	SNP	G	A	A	rs148714049		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:73616108G>A	uc002avp.2	-	8	3320	c.2326C>T	c.(2326-2328)CCG>TCG	p.P776S		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	776	Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		TGGATCAGCGGGGTCCAGATG	0.687													31	6					0	0	1	0	0
STRA6	64220	broad.mit.edu	37	15	74481580	74481580	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:74481580G>A	uc002axk.2	-	12	1148	c.966C>T	c.(964-966)ATC>ATT	p.I322I	STRA6_uc002axi.2_Silent_p.I131I|STRA6_uc010ulh.1_Silent_p.I360I|STRA6_uc002axj.2_Silent_p.I361I|STRA6_uc010bji.2_Silent_p.I322I|STRA6_uc002axl.2_Silent_p.I254I|STRA6_uc002axm.2_Silent_p.I322I|STRA6_uc002axn.2_Silent_p.I313I|STRA6_uc010uli.1_Silent_p.I359I|STRA6_uc010bjj.1_RNA	NM_022369	NP_071764	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid gene 6 homolog	322	Helical; (Potential).				adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			central_nervous_system(1)	1						TCACCTTCTGGATAGTGGGTA	0.622													9	1					0	0	1	0	0
STRA6	64220	broad.mit.edu	37	15	74483560	74483560	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:74483560G>A	uc002axk.2	-	10	995	c.813C>T	c.(811-813)TTC>TTT	p.F271F	STRA6_uc002axi.2_Silent_p.F80F|STRA6_uc010ulh.1_Silent_p.F309F|STRA6_uc002axj.2_Silent_p.F310F|STRA6_uc010bji.2_Silent_p.F271F|STRA6_uc002axl.2_Silent_p.F203F|STRA6_uc002axm.2_Silent_p.F271F|STRA6_uc002axn.2_Silent_p.F262F|STRA6_uc010uli.1_Silent_p.F308F|STRA6_uc010bjj.1_Intron	NM_022369	NP_071764	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid gene 6 homolog	271	Cytoplasmic (Potential).				adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			central_nervous_system(1)	1						CCCAGGACAGGAAGCCATGCT	0.637													33	7					0	0	1	0	0
CHRNB4	1143	broad.mit.edu	37	15	78922179	78922179	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:78922179C>T	uc002bed.1	-	5	580	c.468G>A	c.(466-468)GAG>GAA	p.E156E	CHRNB4_uc002bee.1_Intron|CHRNB4_uc010blh.1_5'UTR	NM_000750	NP_000741	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4	156	Extracellular (Potential).				regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0						AGTACTTCACCTCAATCTTGC	0.562													45	4					0	0	1	0	0
C15orf26	161502	broad.mit.edu	37	15	81426721	81426721	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:81426721G>A	uc002bgb.2	+	1	78	c.51G>A	c.(49-51)GAG>GAA	p.E17E	C15orf26_uc010blp.1_Intron	NM_173528	NP_775799	Q6P656	CO026_HUMAN	hypothetical protein LOC161502	17											0						ACTGGAATGAGGATGTCTACC	0.602													9	2					0	0	1	0	0
POLG	5428	broad.mit.edu	37	15	89869920	89869920	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:89869920G>A	uc002bns.3	-	9	1917	c.1635C>T	c.(1633-1635)GCC>GCT	p.A545A	POLG_uc002bnr.3_Silent_p.A545A	NM_002693	NP_002684	P54098	DPOG1_HUMAN	DNA-directed DNA polymerase gamma	545					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			AGCAGGCGCGGGCCATGACAT	0.617								DNA_polymerases_(catalytic_subunits)					30	9					0	0	1	0	0
SV2B	9899	broad.mit.edu	37	15	91832897	91832897	+	Missense_Mutation	SNP	C	T	T	rs150512068	by1000genomes	TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:91832897C>T	uc002bqv.2	+	11	2246	c.1855C>T	c.(1855-1857)CCC>TCC	p.P619S	SV2B_uc010uqv.1_Missense_Mutation_p.P468S|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	619	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			GGAGCTGTATCCCACCAACCA	0.532													18	7					0	0	1	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92459677	92459677	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:92459677C>T	uc002bqx.2	+	2	836	c.635C>T	c.(634-636)TCG>TTG	p.S212L	SLCO3A1_uc002bqy.2_Missense_Mutation_p.S212L|SLCO3A1_uc010boc.1_RNA|SLCO3A1_uc002bqz.1_Missense_Mutation_p.S154L	NM_013272	NP_037404	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family,	212	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			skin(1)	1	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			AAGGACTCCTCGCTCTATATA	0.587													10	3					0	0	1	0	0
RGS11	8786	broad.mit.edu	37	16	320594	320594	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:320594C>T	uc002cgj.1	-	15	1137	c.1134G>A	c.(1132-1134)CTG>CTA	p.L378L	RGS11_uc002cgi.1_Silent_p.L357L|RGS11_uc010bqs.1_Silent_p.L367L|RGS11_uc002cgk.1_Silent_p.L194L	NM_183337	NP_899180	O94810	RGS11_HUMAN	regulator of G-protein signalling 11 isoform 1	378	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			lung(1)|pancreas(1)	2		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				GCAGCCCCTCCAGGGTCTGCT	0.652													23	9					0	0	1	0	0
PTX4	390667	broad.mit.edu	37	16	1536082	1536082	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:1536082C>T	uc010uvf.1	-	3	1280	c.1280G>A	c.(1279-1281)CGG>CAG	p.R427Q		NM_001013658	NP_001013680	Q96A99	PTX4_HUMAN	neuronal pentraxin II-like	432	Pentaxin.					extracellular region	metal ion binding				0						AACCAGCGCCCGATCCCAGAT	0.627													44	39					0	0	1	0	0
TSC2	7249	broad.mit.edu	37	16	2115518	2115518	+	Splice_Site	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:2115518A>G	uc002con.2	+	16	1706	c.1600_splice	c.e16-2	p.V534_splice	TSC2_uc010bsd.2_Splice_Site_p.V534_splice|TSC2_uc002coo.2_Splice_Site_p.V534_splice|TSC2_uc010uvv.1_Splice_Site_p.V497_splice|TSC2_uc010uvw.1_Splice_Site_p.V485_splice|TSC2_uc002cop.2_Splice_Site_p.V334_splice	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1						cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				TTCTCTTCAAAGGTGATGGCC	0.527			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				12	276					0	0	1	0	0
TBC1D24	57465	broad.mit.edu	37	16	2550412	2550412	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:2550412C>T	uc002cql.2	+	7	1586	c.1446C>T	c.(1444-1446)TTC>TTT	p.F482F	TBC1D24_uc002cqk.2_Silent_p.F476F|TBC1D24_uc002cqm.2_Intron|TBC1D24_uc010bsm.2_RNA	NM_020705	NP_065756	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	482	TLD.				neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity				0						TCTCGCCCTTCCTGGCCGCTC	0.697													9	6					0	0	1	0	0
FLYWCH2	114984	broad.mit.edu	37	16	2946570	2946570	+	Silent	SNP	C	T	T	rs151309938		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:2946570C>T	uc002csa.2	+	3	491	c.120C>T	c.(118-120)TCC>TCT	p.S40S	FLYWCH2_uc010uwj.1_Silent_p.S40S|FLYWCH2_uc010uwk.1_Silent_p.S40S	NM_138439	NP_612448	Q96CP2	FWCH2_HUMAN	FLYWCH family member 2	40											0						GAAAGTTCTCCAAACTGGTCC	0.652													50	138					0	0	1	0	0
OR1F2P	26184	broad.mit.edu	37	16	3266154	3266155	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:3266154_3266155CC>TT	uc010uwv.1	+	1	593_594	c.445_446CC>TT	c.(445-447)CCC>TTC	p.P149F		NR_002169				RecName: Full=Olfactory receptor 1F2; AltName: Full=OLFmf2;												0						CGATGTGACTCCCCTCCTGAAA	0.535													10	52					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3788618	3788618	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:3788618G>A	uc002cvv.2	-	26	4540	c.4336C>T	c.(4336-4338)CGC>TGC	p.R1446C	CREBBP_uc002cvw.2_Missense_Mutation_p.R1408C	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1446	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding	p.R1446H(3)|p.R1446L(2)|p.R1446C(2)		haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		ACGGCTGTGCGGAGGCAACGT	0.413			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				13	37					0	0	1	0	0
C16orf71	146562	broad.mit.edu	37	16	4797541	4797541	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:4797541C>T	uc002cxn.2	+	9	1940	c.1478C>T	c.(1477-1479)CCA>CTA	p.P493L		NM_139170	NP_631909	Q8IYS4	CP071_HUMAN	hypothetical protein LOC146562	493										central_nervous_system(1)	1						GCTCGACTCCCAAGAGGCAGG	0.637													12	11					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857546	9857546	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:9857546C>T	uc002czo.3	-	13	4403	c.3855G>A	c.(3853-3855)AGG>AGA	p.R1285R	GRIN2A_uc010uym.1_Silent_p.R1285R|GRIN2A_uc010uyn.1_Intron|GRIN2A_uc002czr.3_Intron	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1285	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding	p.R1285K(1)		skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GACGGCTAATCCTTAGCTTGT	0.532													28	52					0	0	1	0	0
NUBP1	4682	broad.mit.edu	37	16	10851795	10851795	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:10851795C>T	uc002daa.1	+	7	540	c.517C>T	c.(517-519)CCA>TCA	p.P173S	NUBP1_uc010bum.1_Missense_Mutation_p.P38S|NUBP1_uc002dab.1_Missense_Mutation_p.P162S	NM_002484	NP_002475	P53384	NUBP1_HUMAN	nucleotide binding protein 1	173					cell growth|cellular iron ion homeostasis|iron-sulfur cluster assembly	cytosol	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|nucleoside-triphosphatase activity|protein binding			ovary(1)|skin(1)	2						TGTGGACACCCCACCTGGGAC	0.562													41	121					0	0	1	0	0
CIITA	4261	broad.mit.edu	37	16	11000982	11000982	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:11000982C>A	uc002dai.3	+	11	1766	c.1633C>A	c.(1633-1635)CTC>ATC	p.L545I	CIITA_uc002daj.3_Missense_Mutation_p.L546I|CIITA_uc002dak.3_Intron|CIITA_uc002dag.2_Missense_Mutation_p.L545I|CIITA_uc002dah.2_Missense_Mutation_p.L497I|CIITA_uc010bup.1_Intron	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	545	NACHT.				interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						CACCCTCCTCCTCACAGCCCG	0.697			T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								9	19					1.61879e-10	1.64837e-10	1	1	0
NPIP	9284	broad.mit.edu	37	16	15045731	15045731	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:15045731C>T	uc002dcy.3	+	8	902	c.902C>T	c.(901-903)GCG>GTG	p.A301V	NPIP_uc002dcx.3_RNA	NM_006985	NP_008916	Q9UND3	NPIP_HUMAN	nuclear pore complex interacting protein	301	Pro-rich.				mRNA transport|protein transport|transmembrane transport	nuclear membrane|nuclear pore					0						CCACCCTCAGCGGATGATAAT	0.557													10	174					0	0	1	0	0
Unknown	0	broad.mit.edu	37	16	18434270	18434270	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:18434270G>A	uc010bvu.2	-	1	355	c.68C>T	c.(67-69)ACC>ATC	p.T23I						SubName: Full=cDNA FLJ42525 fis, clone BRACE3001391, highly similar to Polycystin;																		CACCTTCACGGTGATGGCGCG	0.682													9	45					0	0	1	0	0
CP110	9738	broad.mit.edu	37	16	19554303	19554303	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:19554303G>A	uc002dgl.3	+	8	2718	c.2471G>A	c.(2470-2472)CGA>CAA	p.R824Q	CP110_uc002dgk.3_Missense_Mutation_p.R824Q			O43303	CP110_HUMAN	RecName: Full=Centrosomal protein of 110 kDa;          Short=Cep110;	824					centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding				0						AAGCAACTTCGACAAACTGTA	0.348													16	24					0	0	1	0	0
ACSM1	116285	broad.mit.edu	37	16	20648722	20648723	+	Missense_Mutation	DNP	CC	TT	TT	rs142566677		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:20648722_20648723CC>TT	uc002dhm.1	-	8	1235_1236	c.1167_1168GG>AA	c.(1165-1170)ATGGGG>ATAAGG	p.389_390MG>IR	ACSM1_uc002dhn.1_RNA|ACSM1_uc010bwg.1_Missense_Mutation_p.389_390MG>IR	NM_052956	NP_443188	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member	389_390					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|skin(1)	2						GTGGCCTTCCCCATGAAACCCG	0.535													18	59					0	0	1	0	0
CACNG3	10368	broad.mit.edu	37	16	24372999	24372999	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:24372999C>T	uc002dmf.2	+	4	1963	c.763C>T	c.(763-765)CAC>TAC	p.H255Y		NM_006539	NP_006530	O60359	CCG3_HUMAN	voltage-dependent calcium channel gamma-3	255					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0				GBM - Glioblastoma multiforme(48;0.0809)		CAAAGGCTTCCACACCATCCC	0.612													62	51					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27506150	27506150	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:27506150G>A	uc002dov.1	-	16	2752	c.2712C>T	c.(2710-2712)CTC>CTT	p.L904L	GTF3C1_uc002dou.2_Silent_p.L904L	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	904						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						TGTCGCTGACGAGAGCCCAGC	0.532													43	31					0	0	1	0	0
CLN3	1201	broad.mit.edu	37	16	28497721	28497721	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:28497721G>A	uc002dpo.2	-	8	947	c.624C>T	c.(622-624)TCC>TCT	p.S208S	uc010vct.1_Intron|CLN3_uc002dpl.2_Silent_p.S130S|CLN3_uc010vcu.1_Silent_p.S108S|CLN3_uc002dpn.2_Intron|CLN3_uc002dpm.2_Silent_p.S154S|CLN3_uc010vcv.1_Silent_p.S184S|CLN3_uc010byd.2_Silent_p.S208S|CLN3_uc002dpp.2_Silent_p.S208S|CLN3_uc002dpt.1_Silent_p.S108S|CLN3_uc002dpq.1_Intron|CLN3_uc010bye.1_Silent_p.S208S|CLN3_uc002dpr.1_Intron|CLN3_uc010byf.1_Intron|CLN3_uc002dps.1_Intron|CLN3_uc002dpu.1_Intron|CLN3_uc002dpw.1_Intron|CLN3_uc010vcw.1_Silent_p.S154S|CLN3_uc002dqa.2_Silent_p.S259S|CLN3_uc010vcx.1_Silent_p.S108S|CLN3_uc002dpx.1_Intron|CLN3_uc002dpy.1_Intron|CLN3_uc002dpz.1_RNA	NM_000086	NP_000077	Q13286	CLN3_HUMAN	ceroid-lipofuscinosis, neuronal 3	208					amyloid precursor protein catabolic process|arginine transport|associative learning|autophagic vacuole fusion|cell death|cellular amino acid metabolic process|cytosolic calcium ion homeostasis|galactosylceramide metabolic process|globoside metabolic process|glucosylceramide metabolic process|ionotropic glutamate receptor signaling pathway|lysosomal lumen acidification|lysosomal lumen pH elevation|negative regulation of catalytic activity|negative regulation of macroautophagy|negative regulation of neuron apoptosis|negative regulation of proteolysis|neuromuscular process controlling balance|neurotransmitter metabolic process|protein catabolic process|protein folding|protein processing|receptor-mediated endocytosis|regulation of action potential|sphingomyelin metabolic process|vacuolar transport	autophagic vacuole|caveola|cytosol|early endosome|Golgi membrane|Golgi stack|integral to endoplasmic reticulum membrane|late endosome|lysosomal membrane|membrane fraction|mitochondrion|neuron projection|nucleus|synaptic vesicle|trans-Golgi network	unfolded protein binding				0						TCTGCTGAGGGGAGAGGCCGG	0.682													23	14					0	0	1	0	0
NUPR1	26471	broad.mit.edu	37	16	28549463	28549464	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:28549463_28549464CC>TT	uc002dqe.1	-	2	392_393	c.125_126GG>AA	c.(124-126)CGG>CAA	p.R42Q	uc010vct.1_Intron|NUPR1_uc002dqd.1_Missense_Mutation_p.R60Q	NM_012385	NP_036517	O60356	NUPR1_HUMAN	p8 protein isoform b	42					cell growth|induction of apoptosis	nucleus					0						TGCGACCTTTCCGGCCTCCACC	0.599													34	89					0	0	1	0	0
KIF22	3835	broad.mit.edu	37	16	29816329	29816330	+	Missense_Mutation	DNP	CC	AT	AT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:29816329_29816330CC>AT	uc002dts.3	+	12	1896_1897	c.1872_1873CC>AT	c.(1870-1875)CTCCAC>CTATAC	p.H625Y	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|KIF22_uc010vdv.1_Missense_Mutation_p.H557Y|KIF22_uc010vdw.1_Missense_Mutation_p.H557Y|KIF22_uc010bzf.2_Missense_Mutation_p.H571Y|KIF22_uc002dtt.1_3'UTR|KIF22_uc002frc.1_RNA|MAZ_uc002dtv.1_5'Flank|MAZ_uc010vdx.1_5'Flank|MAZ_uc002dtw.2_5'Flank|MAZ_uc002dtx.2_5'Flank|MAZ_uc002dty.2_5'Flank|MAZ_uc010bzg.2_5'Flank|MAZ_uc002dtz.1_5'Flank	NM_007317	NP_015556	Q14807	KIF22_HUMAN	kinesin family member 22	625					blood coagulation|DNA repair|microtubule-based movement|mitosis	cytosol|kinetochore|microtubule|nucleus	ATP binding|DNA binding|microtubule motor activity|protein binding				0						GGCGGGAGCTCCACGGCCCCTT	0.658													17	49					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30732064	30732065	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:30732064_30732065CC>TT	uc002dze.1	+	20	3403_3404	c.3018_3019CC>TT	c.(3016-3021)GGCCGG>GGTTGG	p.R1007W	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.R864W|SRCAP_uc010bzz.1_Missense_Mutation_p.R577W	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1007	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			AGCAAGAAGGCCGGACAGTGGT	0.559													50	107					0	0	1	0	0
SETD1A	9739	broad.mit.edu	37	16	30982823	30982823	+	Silent	SNP	C	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:30982823C>G	uc002ead.1	+	13	3827	c.3141C>G	c.(3139-3141)TCC>TCG	p.S1047S		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	1047	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						cctcctcctcctcgtcctcat	0.413													3	56					0	0	1	0	0
ZNF267	10308	broad.mit.edu	37	16	31927242	31927242	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:31927242C>T	uc002ecs.3	+	4	1881	c.1672C>T	c.(1672-1674)CCT>TCT	p.P558S		NM_003414	NP_003405	Q14586	ZN267_HUMAN	zinc finger protein 267	558	C2H2-type 9.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)|skin(1)	4						CAAAGCCTTTCCTTATAGTTC	0.353													25	12					0	0	1	0	0
CCL22	6367	broad.mit.edu	37	16	57397450	57397450	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:57397450G>A	uc002elh.2	+	3	243	c.232G>A	c.(232-234)GAT>AAT	p.D78N		NM_002990	NP_002981	O00626	CCL22_HUMAN	small inducible cytokine A22 precursor	78					cell-cell signaling|chemotaxis|immune response|inflammatory response|response to virus|signal transduction	extracellular space	chemokine activity				0						GATCTGTGCCGATCCCAGAGT	0.542													13	45					0	0	1	0	0
TEPP	374739	broad.mit.edu	37	16	58010475	58010475	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:58010475A>G	uc002emw.3	+	1	137	c.100A>G	c.(100-102)ACT>GCT	p.T34A	TEPP_uc002emv.3_Missense_Mutation_p.T34A	NM_199456	NP_955535	Q6URK8	TEPP_HUMAN	testis/prostate/placenta-expressed protein	34						extracellular region				kidney(1)|central_nervous_system(1)|skin(1)	3						CAGTCAAAGAACTGAAAGTCC	0.512													38	32					0	0	1	0	0
MMP15	4324	broad.mit.edu	37	16	58073817	58073817	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:58073817C>T	uc002ena.2	+	4	1452	c.479C>T	c.(478-480)TCG>TTG	p.S160L		NM_002428	NP_002419	P51511	MMP15_HUMAN	matrix metalloproteinase 15 preproprotein	160	Extracellular (Potential).				protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			central_nervous_system(2)|breast(1)	3						TGGTACCACTCGATGGAGGCG	0.647													76	41					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58589735	58589735	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:58589735G>A	uc002env.2	-	20	2850	c.2557C>T	c.(2557-2559)CAG>TAG	p.Q853*	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Nonsense_Mutation_p.Q848*|CNOT1_uc002enx.2_Nonsense_Mutation_p.Q853*|CNOT1_uc002enz.1_Nonsense_Mutation_p.Q282*	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	853					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TATATTCGCTGGAAATAGCTG	0.398													18	70					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58617062	58617062	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:58617062G>A	uc002env.2	-	9	1124	c.831C>T	c.(829-831)ATC>ATT	p.I277I	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Silent_p.I277I|CNOT1_uc002enx.2_Silent_p.I277I|CNOT1_uc002enz.1_Intron	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	277					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		CAAACTGCACGATTATATTGC	0.418													12	61					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61689437	61689437	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:61689437G>A	uc002eog.1	-	11	2095	c.1843C>T	c.(1843-1845)CTT>TTT	p.L615F		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	615	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		CCAATTGGAAGGACATAAGCT	0.478													18	58					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61761101	61761101	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:61761101G>A	uc002eog.1	-	9	1685	c.1433C>T	c.(1432-1434)TCA>TTA	p.S478L	CDH8_uc002eoh.2_Missense_Mutation_p.S247L	NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	478	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		AGGTACTCGTGATATCTGACT	0.413													9	37					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66943216	66943216	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:66943216C>T	uc002eql.2	-	17	2419	c.2346G>A	c.(2344-2346)ACG>ACA	p.T782T	CDH16_uc010cdy.2_Silent_p.T760T|CDH16_uc002eqm.2_Silent_p.T685T	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	782	Extracellular (Potential).|Ectodomain G.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		CCGACAGCTTCGTGGGCATGC	0.527													45	33					0	0	1	0	0
KIAA0895L	653319	broad.mit.edu	37	16	67214001	67214001	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:67214001G>A	uc002ert.2	-	2	1288	c.513C>T	c.(511-513)CCC>CCT	p.P171P	KIAA0895L_uc002err.2_5'Flank|KIAA0895L_uc002ers.2_5'Flank|KIAA0895L_uc002eru.2_Silent_p.P171P|EXOC3L_uc002erv.1_RNA	NM_001040715	NP_001035805	Q68EN5	K895L_HUMAN	hypothetical protein LOC653319	171											0						CCGTGGGCATGGGCTCCTGGT	0.577													53	33					0	0	1	0	0
SF3B3	23450	broad.mit.edu	37	16	70562809	70562809	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:70562809G>T	uc002ezf.2	+	3	315	c.104G>T	c.(103-105)GGG>GTG	p.G35V	SNORD111B_uc010cfv.1_5'Flank	NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	35					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				GTTTCCCGTGGGAAGATCTTG	0.383													13	53					6.49762e-13	6.6309e-13	1	1	0
ZFHX3	463	broad.mit.edu	37	16	72830075	72830075	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:72830075G>A	uc002fck.2	-	9	7179	c.6506C>T	c.(6505-6507)TCC>TTC	p.S2169F	ZFHX3_uc002fcl.2_Missense_Mutation_p.S1255F	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	2169	Homeobox 1.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				TTCACTGGGGGAGTTGTTAAT	0.502													53	45					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77334279	77334279	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:77334279G>A	uc002ffc.3	-	17	2974	c.2555C>T	c.(2554-2556)CCA>CTA	p.P852L	ADAMTS18_uc010chc.1_Missense_Mutation_p.P440L|ADAMTS18_uc002ffe.1_Missense_Mutation_p.P548L	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	852	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						AGCTATCCCTGGATTTTTGCC	0.438													22	78					0	0	1	0	0
PLCG2	5336	broad.mit.edu	37	16	81972454	81972454	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:81972454C>T	uc002fgt.2	+	29	3399	c.3247C>T	c.(3247-3249)CCC>TCC	p.P1083S		NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	1083	C2.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						TATTGCCTGTCCCTTTGTAGA	0.527													38	18					0	0	1	0	0
FBXO31	79791	broad.mit.edu	37	16	87367807	87367807	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:87367807C>T	uc002fjw.2	-	8	1126	c.1082G>A	c.(1081-1083)CGC>CAC	p.R361H	FBXO31_uc010vot.1_Missense_Mutation_p.R189H|FBXO31_uc002fjv.2_Missense_Mutation_p.R253H	NM_024735	NP_079011	Q5XUX0	FBX31_HUMAN	F-box protein 31	361					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0272)		ATTGAAGTTGCGCTGGTTCTC	0.682													8	155					0	0	1	0	0
SNAI3	333929	broad.mit.edu	37	16	88747685	88747685	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:88747685G>A	uc002flj.2	-	2	582	c.514C>T	c.(514-516)CAG>TAG	p.Q172*	MGC23284_uc002fli.3_Intron	NM_178310	NP_840101	Q3KNW1	SNAI3_HUMAN	snail homolog 3	172	C2H2-type 1.				oxidation-reduction process		copper ion binding|DNA binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.048)		CAGTGCAGCTGCCGGTGCCTG	0.652													77	38					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89351844	89351844	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:89351844T>C	uc002fmx.1	-	9	1567	c.1106A>G	c.(1105-1107)AAG>AGG	p.K369R	ANKRD11_uc002fmy.1_Missense_Mutation_p.K369R|ANKRD11_uc002fnc.1_Missense_Mutation_p.K369R|ANKRD11_uc002fnb.1_Missense_Mutation_p.K326R	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	369						nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TCTGTAGTCCTTTTTCAATAG	0.453													3	152					0	0	1	0	0
CDK10	8558	broad.mit.edu	37	16	89759817	89759817	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:89759817C>T	uc010cio.2	+	8	593	c.550C>T	c.(550-552)CTG>TTG	p.L184L	CDK10_uc010cip.2_3'UTR|CDK10_uc010vpl.1_3'UTR|CDK10_uc002fob.2_Intron|CDK10_uc002fod.2_Silent_p.L113L|CDK10_uc002foe.2_Silent_p.L113L|CDK10_uc002fof.2_Silent_p.L113L|CDK10_uc002fog.3_Silent_p.L113L|CDK10_uc002foh.3_Silent_p.L113L|CDK10_uc002foi.2_5'Flank	NM_052988	NP_443714	Q15131	CDK10_HUMAN	cyclin-dependent kinase 10 isoform a	184	Protein kinase.				negative regulation of cell proliferation|traversing start control point of mitotic cell cycle		ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(1)	1		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0276)		GGATTTCGGCCTGGCCCGGGC	0.607													40	82					0	0	1	0	0
ZNF276	92822	broad.mit.edu	37	16	89789220	89789220	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:89789220G>A	uc002fos.3	+	2	584	c.487G>A	c.(487-489)GGT>AGT	p.G163S	C16orf7_uc002fom.1_5'Flank|ZNF276_uc010ciq.2_5'UTR|ZNF276_uc002fop.2_Missense_Mutation_p.G88S|ZNF276_uc002foq.3_Missense_Mutation_p.G88S|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_5'UTR|ZNF276_uc010cis.2_5'UTR|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_5'Flank|ZNF276_uc010cit.1_5'Flank	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a	163					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CTCCCCGGCTGGTCGCCGGAA	0.592													53	47					0	0	1	0	0
FANCA	2175	broad.mit.edu	37	16	89811436	89811436	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:89811436C>T	uc002fou.1	-	36	3599	c.3557G>A	c.(3556-3558)AGG>AAG	p.R1186K	FANCA_uc010vpn.1_Missense_Mutation_p.R1186K|FANCA_uc010vpo.1_Missense_Mutation_p.R272K	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	1186					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		GCAGTGTCTCCTCCACCGGCA	0.637			D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				7	21					0	0	1	0	0
ZFP3	124961	broad.mit.edu	37	17	4995165	4995166	+	Silent	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:4995165_4995166CC>TT	uc002gaq.2	+	2	491_492	c.366_367CC>TT	c.(364-369)TTCCTA>TTTTTA	p.122_123FL>FL		NM_153018	NP_694563	Q96NJ6	ZFP3_HUMAN	zinc finger protein-3	122_123					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCCAAAACTTCCTAGAGATTTT	0.431													11	35					0	0	1	0	0
DHX33	56919	broad.mit.edu	37	17	5372023	5372023	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:5372023G>A	uc002gca.2	-	1	159	c.157C>T	c.(157-159)CCG>TCG	p.P53S	DHX33_uc002gcb.2_5'UTR|DHX33_uc010clf.2_Missense_Mutation_p.P53S	NM_020162	NP_064547	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	53						nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|pancreas(1)	2						GCCAGGGGCGGCTGCTGCCTC	0.711													3	27					0	0	1	0	0
DERL2	51009	broad.mit.edu	37	17	5383874	5383874	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:5383874A>G	uc002gcc.1	-	5	372	c.356T>C	c.(355-357)TTC>TCC	p.F119S		NM_016041	NP_057125	Q9GZP9	DERL2_HUMAN	Der1-like domain family, member 2	119	Cytoplasmic (Potential).				endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of cell growth|positive regulation of cell proliferation|retrograde protein transport, ER to cytosol	integral to endoplasmic reticulum membrane	protein binding				0						CTGGCCCAAGAAAACTAAGCT	0.443													64	8					0	0	1	0	0
NEURL4	84461	broad.mit.edu	37	17	7230914	7230914	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:7230914G>A	uc002gga.1	-	2	579	c.572C>T	c.(571-573)GCC>GTC	p.A191V	NEURL4_uc002ggb.1_Missense_Mutation_p.A191V|NEURL4_uc002ggc.1_5'Flank	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	191	NHR 1.						protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						GTCCACGACGGCCCAGACACG	0.677													28	3					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577559	7577559	+	Missense_Mutation	SNP	G	A	A	rs28934573		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:7577559G>A	uc002gim.2	-	7	916	c.722C>T	c.(721-723)TCC>TTC	p.S241F	TP53_uc002gig.1_Missense_Mutation_p.S241F|TP53_uc002gih.2_Missense_Mutation_p.S241F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.S109F|TP53_uc010cng.1_Missense_Mutation_p.S109F|TP53_uc002gii.1_Missense_Mutation_p.S109F|TP53_uc010cnh.1_Missense_Mutation_p.S241F|TP53_uc010cni.1_Missense_Mutation_p.S241F|TP53_uc002gij.2_Missense_Mutation_p.S241F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.S148F|TP53_uc002gio.2_Missense_Mutation_p.S109F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	241	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		S -> A (in sporadic cancers; somatic mutation).|S -> P (in sporadic cancers; somatic mutation).|S -> C (in sporadic cancers; somatic mutation).|S -> Y (in sporadic cancers; somatic mutation).|S -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S241F(73)|p.S241C(24)|p.S241fs*6(8)|p.0?(7)|p.S241Y(7)|p.C242fs*5(6)|p.S241A(6)|p.S241del(5)|p.S241T(5)|p.N239_C242delNSSC(3)|p.S241S(3)|p.S241P(3)|p.S241fs*22(2)|p.Y236_M243delYMCNSSCM(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_C242insX(1)|p.S241_G245delSCMGG(1)|p.C238fs*21(1)|p.S241fs*7(1)|p.H233_C242del10(1)|p.N239_C242>S(1)|p.S241fs*23(1)|p.N239_C242del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCCATGCAGGAACTGTTACA	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			70	9					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7661952	7661952	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:7661952C>T	uc002giu.1	+	13	2205	c.2191C>T	c.(2191-2193)CGT>TGT	p.R731C		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	731	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CACGGAGTGCCGTATACATGC	0.527													31	7					0	0	1	0	0
KDM6B	23135	broad.mit.edu	37	17	7749422	7749422	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:7749422G>A	uc002giw.1	+	6	639	c.263G>A	c.(262-264)GGG>GAG	p.G88E	KDM6B_uc002gix.2_5'Flank	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	88					inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CCCCTCCATGGGAAGCTGGAA	0.632													23	6					0	0	1	0	0
KDM6B	23135	broad.mit.edu	37	17	7751588	7751588	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:7751588G>A	uc002giw.1	+	11	2358	c.1982G>A	c.(1981-1983)GGG>GAG	p.G661E	KDM6B_uc002gix.2_5'UTR	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	661	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CCCGGGGTTGGGGAGCTGCCT	0.682													52	9					0	0	1	0	0
CHD3	1107	broad.mit.edu	37	17	7802714	7802714	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:7802714C>T	uc002gje.2	+	15	2547	c.2397C>T	c.(2395-2397)AAC>AAT	p.N799N	CHD3_uc002gjd.2_Silent_p.N858N|CHD3_uc002gjf.2_Silent_p.N799N	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	799	Helicase ATP-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				CCATCATTAACTGGGAGCGGG	0.537													130	18					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10209938	10209938	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:10209938C>T	uc002gmk.1	-	37	5394	c.5304G>A	c.(5302-5304)ATG>ATA	p.M1768I		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1768	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						CCTCAGCCATCATGGCAGCCT	0.582													43	3					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10397696	10397696	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:10397696G>A	uc002gmo.2	-	39	5736	c.5642C>T	c.(5641-5643)TCC>TTC	p.S1881F	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1881	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TCTCTTGTAGGATTTCACCTT	0.433													93	13					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10448788	10448788	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:10448788T>C	uc010coi.2	-	5	508	c.380A>G	c.(379-381)AAC>AGC	p.N127S	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.N127S|MYH2_uc010coj.2_Missense_Mutation_p.N127S	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	127	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CTTGTAGGGGTTGACAGTGAC	0.473													48	7					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11556319	11556319	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:11556319G>A	uc002gne.2	+	14	2663	c.2595G>A	c.(2593-2595)CAG>CAA	p.Q865Q	DNAH9_uc010coo.2_Silent_p.Q159Q	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	865	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CCCTTGTTCAGGTAATAACCC	0.428													55	2					0	0	1	0	0
TBC1D26	353149	broad.mit.edu	37	17	15641669	15641669	+	Silent	SNP	A	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:15641669A>C	uc010cov.2	+	7	605	c.355A>C	c.(355-357)AGA>CGA	p.R119R	TBC1D26_uc010cou.1_Silent_p.R119R|TBC1D26_uc002gpb.3_RNA	NM_178571	NP_848666	Q86UD7	TBC26_HUMAN	TBC1 domain family, member 26	119	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(1115;0.0222)|BRCA - Breast invasive adenocarcinoma(8;0.078)		AGATATTGACAGAATCAAGTC	0.502													47	66					0	0	1	0	0
Unknown	0	broad.mit.edu	37	17	16725634	16725634	+	RNA	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:16725634G>A	uc002gqq.1	-	1		c.260C>T								full-length cDNA clone CS0DI013YN06 of Placenta Cot 25-normalized of Homo sapiens (human).																		TCCCCCAGAGGAGAAGCAGGA	0.532													4	5					0	0	1	0	0
FLII	2314	broad.mit.edu	37	17	18149956	18149956	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:18149956G>A	uc002gsr.1	-	23	3054	c.3003C>T	c.(3001-3003)ACC>ACT	p.T1001T	FLII_uc002gsq.1_Silent_p.T872T|FLII_uc010cpy.1_Silent_p.T990T|FLII_uc010vxn.1_Silent_p.T970T|FLII_uc010vxo.1_Silent_p.T946T|FLII_uc002gss.1_Silent_p.T1000T	NM_002018	NP_002009	Q13045	FLII_HUMAN	flightless I homolog	1001					multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(1)|skin(1)	2	all_neural(463;0.228)					GCAGGCTGAAGGTGAAGGTGA	0.527													17	15					0	0	1	0	0
FBXW10	10517	broad.mit.edu	37	17	18661787	18661787	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:18661787C>T	uc002guk.2	+	7	1634	c.1402C>T	c.(1402-1404)CTC>TTC	p.L468F	FBXW10_uc002guj.2_Missense_Mutation_p.L468F|FBXW10_uc002gul.2_Missense_Mutation_p.L497F|FBXW10_uc010cqh.1_Missense_Mutation_p.L468F	NM_031456	NP_113644	Q5XX13	FBW10_HUMAN	F-box and WD-40 domain protein 10	468	WD 3.									ovary(1)	1						GGAAAACTTTCTCCTAAGCGG	0.527													6	45					0	0	1	0	0
RNF112	7732	broad.mit.edu	37	17	19318162	19318163	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:19318162_19318163GG>AA	uc010vyw.1	+	10	1287_1288	c.1088_1089GG>AA	c.(1087-1089)GGG>GAA	p.G363E	RNF112_uc010vyv.1_Missense_Mutation_p.G363E|RNF112_uc010vyx.1_Missense_Mutation_p.G246E	NM_007148	NP_009079	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	363							GTP binding|GTPase activity|zinc ion binding			ovary(2)	2						CCTGCCCCAGGGAGGCGGCGGA	0.634													27	4					0	0	1	0	0
ALDH3A1	218	broad.mit.edu	37	17	19648365	19648365	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:19648365C>T	uc010cqu.2	-	1	408	c.78G>A	c.(76-78)CGG>CGA	p.R26R	ALDH3A1_uc010vzd.1_Silent_p.R26R|ALDH3A1_uc002gwj.2_Silent_p.R26R|ALDH3A1_uc010cqv.2_Silent_p.R26R|ALDH3A1_uc002gwk.2_Intron|ALDH3A1_uc002gwl.1_5'Flank	NM_001135168	NP_001128640	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3A1	26					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase			ovary(1)|pancreas(1)	2	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	GCTGCTGGATCCGGAACTGCA	0.706													9	1					0	0	1	0	0
Unknown	0	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	G	G	rs149119138	by1000genomes	TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:21731144T>G	uc002gyy.3	+	2	571	c.446T>G	c.(445-447)CTG>CGG	p.L149R						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;																		GTCCTGCGTCTGAGAGGTGGT	0.542													4	70					0	0	1	0	0
FLJ36000	284124	broad.mit.edu	37	17	21904116	21904116	+	RNA	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:21904116G>A	uc002gza.2	+	1		c.55G>A				NR_027084				Homo sapiens cDNA FLJ36000 fis, clone TESTI2015180.												0						cggctgccaggagtcgcaagg	0													4	87					0	0	1	0	0
FLJ40504	284085	broad.mit.edu	37	17	26604400	26604400	+	Silent	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:26604400T>C	uc002has.3	-	3	171	c.75A>G	c.(73-75)AAA>AAG	p.K25K		NM_173624	NP_775895			SubName: Full=Putative uncharacterized protein FLJ40504; SubName: Full=cDNA FLJ40504 fis, clone TESTI2045509, highly similar to KERATIN, TYPE I CYTOSKELETAL 18;												0	all_lung(13;0.000238)|Lung NSC(42;0.000789)			UCEC - Uterine corpus endometrioid carcinoma (53;0.155)		AGGACTCAGGTTTTGACGGCC	0.443													54	3					0	0	1	0	0
SUPT6H	6830	broad.mit.edu	37	17	27004735	27004735	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:27004735C>T	uc002hby.2	+	8	990	c.900C>T	c.(898-900)CTC>CTT	p.L300L	SUPT6H_uc010crt.2_Silent_p.L300L	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	300					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					CACTCCAGCTCCGCTCCATCC	0.463													67	98					0	0	1	0	0
GAS2L2	246176	broad.mit.edu	37	17	34072047	34072047	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:34072047C>T	uc002hjv.1	-	6	2497	c.2469G>A	c.(2467-2469)AAG>AAA	p.K823K		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	823					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCTCCCCTCCCTTGCTGCCCA	0.542													75	10					0	0	1	0	0
PSMD3	5709	broad.mit.edu	37	17	38142889	38142889	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:38142889C>T	uc002htn.1	+	3	637	c.473C>T	c.(472-474)CCC>CTC	p.P158L	PSMD3_uc010wen.1_RNA|PSMD3_uc010weo.1_Missense_Mutation_p.P59L	NM_002809	NP_002800	O43242	PSMD3_HUMAN	proteasome 26S non-ATPase subunit 3	158				TP -> NT (in Ref. 5; AAH12302).	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	enzyme regulator activity|protein binding			ovary(1)|pancreas(1)	2	Colorectal(19;0.000442)					GCGTCGACACCCCTCCTGCCT	0.532													156	23					0	0	1	0	0
CSF3	1440	broad.mit.edu	37	17	38172816	38172816	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:38172816G>A	uc002htp.2	+	4	431	c.391G>A	c.(391-393)GAG>AAG	p.E131K	CSF3_uc002hto.2_Missense_Mutation_p.E128K|CSF3_uc002htq.2_Missense_Mutation_p.E124K|CSF3_uc010wep.1_Missense_Mutation_p.E88K	NM_000759	NP_000750	P09919	CSF3_HUMAN	colony stimulating factor 3 isoform a precursor	131					cytokine-mediated signaling pathway|granulocyte differentiation|immune response|positive regulation of cell proliferation	extracellular space	cytokine activity|enzyme binding|granulocyte colony-stimulating factor receptor binding|growth factor activity			ovary(1)	1	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	GATCTCCCCCGAGTTGGGTCC	0.627													129	24					0	0	1	0	0
KRT23	25984	broad.mit.edu	37	17	39092524	39092524	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:39092524C>T	uc002hvm.1	-	2	921	c.332G>A	c.(331-333)AGA>AAA	p.R111K	KRT23_uc010wfl.1_Intron|KRT23_uc010cxf.1_Intron|KRT23_uc010cxg.2_Missense_Mutation_p.R111K|KRT23_uc002hvn.1_Missense_Mutation_p.R111K	NM_015515	NP_056330	Q9C075	K1C23_HUMAN	keratin 23	111	Rod.|Linker 1.					intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)|Ovarian(249;0.15)				GCCAGGATCTCTCTGCTGGTG	0.547													59	8					0	0	1	0	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39262110	39262110	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:39262110C>T	uc010wfp.1	+	1	470	c.470C>T	c.(469-471)TCC>TTC	p.S157F		NM_001146041	NP_001139513	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	157	29 X 5 AA repeats of C-C-[RQVHIEK]- [SPTR]-[VSTQCRNP].					keratin filament					0						tgcagcatctccagctgctgc	0.134													12	5					0	0	1	0	0
GHDC	84514	broad.mit.edu	37	17	40343158	40343158	+	Silent	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:40343158A>G	uc002hzd.2	-	5	1444	c.960T>C	c.(958-960)TTT>TTC	p.F320F	GHDC_uc002hzg.1_Silent_p.F320F|GHDC_uc010wgg.1_Silent_p.F281F|GHDC_uc002hze.3_Silent_p.F320F|GHDC_uc002hzf.3_Silent_p.F320F	NM_032484	NP_115873	Q8N2G8	GHDC_HUMAN	LGP1 homolog isoform 1	320						endoplasmic reticulum|nuclear envelope					0		all_cancers(22;0.000229)|Breast(137;0.00104)|all_epithelial(22;0.00304)		BRCA - Breast invasive adenocarcinoma(366;0.124)		GCAGCTCGATAAAGGGGGCCC	0.627													37	13					0	0	1	0	0
WNK4	65266	broad.mit.edu	37	17	40939481	40939481	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:40939481C>T	uc002ibj.2	+	7	1683	c.1662C>T	c.(1660-1662)TTC>TTT	p.F554F	WNK4_uc010wgx.1_Silent_p.F218F|WNK4_uc002ibk.1_Silent_p.F326F|WNK4_uc010wgy.1_5'UTR	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	554					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CCAGTGTCTTCCCCCCTGAGC	0.607													131	16					0	0	1	0	0
CNTD1	124817	broad.mit.edu	37	17	40958723	40958723	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:40958723G>A	uc002ibm.3	+	5	844	c.612G>A	c.(610-612)AGG>AGA	p.R204R	CNTD1_uc010wha.1_Silent_p.R121R	NM_173478	NP_775749	Q8N815	CNTD1_HUMAN	cyclin N-terminal domain containing 1	204										central_nervous_system(1)	1		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CAGCCATGAGGCTGCATGCAA	0.468													180	20					0	0	1	0	0
NBR1	4077	broad.mit.edu	37	17	41349035	41349035	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:41349035C>T	uc010czd.2	+	16	2078	c.1938C>T	c.(1936-1938)ACC>ACT	p.T646T	NBR1_uc010diz.2_Silent_p.T646T|NBR1_uc010whu.1_Silent_p.T646T|NBR1_uc010whv.1_Silent_p.T646T|NBR1_uc010whw.1_Silent_p.T625T	NM_031862	NP_114068	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	646					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			skin(1)	1		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		TGAGTGGGACCCAGTTTGTGT	0.493													44	9					0	0	1	0	0
CDC27	996	broad.mit.edu	37	17	45234324	45234324	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:45234324C>T	uc002ild.3	-	7	924	c.797G>A	c.(796-798)CGA>CAA	p.R266Q	CDC27_uc002ile.3_Missense_Mutation_p.R266Q|CDC27_uc002ilf.3_Missense_Mutation_p.R266Q|CDC27_uc010wkp.1_Missense_Mutation_p.R205Q|CDC27_uc010wkq.1_RNA	NM_001256	NP_001247	P30260	CDC27_HUMAN	cell division cycle protein 27 isoform 2	266					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5						TAATAAACTTCGACCAGTTTT	0.358													10	94					0	0	1	0	0
TAC4	255061	broad.mit.edu	37	17	47921472	47921472	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:47921472C>T	uc002ipo.1	-	2	171	c.171G>A	c.(169-171)ACG>ACA	p.T57T	TAC4_uc002ipp.1_Silent_p.T51T|TAC4_uc002ipq.1_Silent_p.T51T|TAC4_uc002ipr.1_Silent_p.T51T|TAC4_uc002ips.1_Silent_p.T51T|TAC4_uc002ipt.2_RNA|TAC4_uc002ipu.2_RNA	NM_170685	NP_733786	Q86UU9	TKN4_HUMAN	tachykinin 4 isoform alpha	57					regulation of blood pressure	extracellular region				breast(1)	1						TTGCCTTGCCCGTCTTCACCT	0.577													189	23					0	0	1	0	0
DLX3	1747	broad.mit.edu	37	17	48072097	48072097	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:48072097C>T	uc002ipy.2	-	1	492	c.266G>A	c.(265-267)GGA>GAA	p.G89E		NM_005220	NP_005211	O60479	DLX3_HUMAN	distal-less homeobox 3	89						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GTAGGAGGCTCCGTAGGTATA	0.622													5	49					0	0	1	0	0
DGKE	8526	broad.mit.edu	37	17	54940014	54940014	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:54940014G>A	uc002iur.2	+	12	1746	c.1566G>A	c.(1564-1566)GGG>GGA	p.G522G	DGKE_uc002ius.1_3'UTR	NM_003647	NP_003638	P52429	DGKE_HUMAN	diacylglycerol kinase epsilon	522					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|phospholipid biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding|protein binding			breast(2)	2	Breast(9;3.59e-07)					AGGTGGATGGGGAGCCTTGGG	0.433													8	2					0	0	1	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62788589	62788589	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:62788589G>A	uc002jew.3	-	8	2051	c.1140C>T	c.(1138-1140)AAC>AAT	p.N380N	PLEKHM1P_uc002jev.3_RNA	NR_024386				RecName: Full=Putative pleckstrin homology domain-containing family M member 1P;												0						ACAGAGACGCGTTCACCATCT	0.627													36	102					0	0	1	0	0
ARSG	22901	broad.mit.edu	37	17	66416533	66416533	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:66416533T>C	uc002jhc.2	+	12	2303	c.1507T>C	c.(1507-1509)TAC>CAC	p.Y503H	ARSG_uc002jhb.1_Missense_Mutation_p.Y339H|ARSG_uc010dex.1_RNA	NM_014960	NP_055775	Q96EG1	ARSG_HUMAN	Arylsulfatase G precursor	503					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			CAGCGCAGATTACACTCAGGA	0.527													124	157					0	0	1	0	0
WIPI1	55062	broad.mit.edu	37	17	66426264	66426264	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:66426264C>T	uc010dey.2	-	9	929	c.838G>A	c.(838-840)GGA>AGA	p.G280R	WIPI1_uc002jhd.3_RNA|WIPI1_uc010wqo.1_Missense_Mutation_p.G198R|WIPI1_uc002jhe.3_RNA	NM_017983	NP_060453	Q5MNZ9	WIPI1_HUMAN	WD repeat domain, phosphoinositide interacting	280					macroautophagy|vesicle targeting, trans-Golgi to endosome	autophagic vacuole membrane|clathrin-coated vesicle|cytosol|endosome membrane|PAS complex|pre-autophagosomal structure membrane|trans-Golgi network	androgen receptor binding|estrogen receptor binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding				0						AACATCTTTCCCATGTAGCCA	0.562													17	38					0	0	1	0	0
GPR142	350383	broad.mit.edu	37	17	72368372	72368372	+	Missense_Mutation	SNP	G	A	A	rs138844667		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:72368372G>A	uc010wqy.1	+	4	1022	c.1022G>A	c.(1021-1023)CGG>CAG	p.R341Q	GPR142_uc010wqx.1_Missense_Mutation_p.R253Q	NM_181790	NP_861455	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	341	Cytoplasmic (Potential).					cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CACCGGCTACGGAGGAGGGGC	0.637													12	23					0	0	1	0	0
CD300A	11314	broad.mit.edu	37	17	72469847	72469847	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:72469847G>A	uc002jkv.2	+	2	534	c.213G>A	c.(211-213)AGG>AGA	p.R71R	CD300A_uc002jkw.2_Intron|CD300A_uc010dfr.2_Intron|CD300A_uc010dfs.2_Intron	NM_007261	NP_009192	Q9UGN4	CLM8_HUMAN	leukocyte membrane antigen	71	Extracellular (Potential).|Ig-like V-type.				cell adhesion	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2						CAGGAAAAAGGAACGGCCGAG	0.522													25	47					0	0	1	0	0
USH1G	124590	broad.mit.edu	37	17	72916645	72916645	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:72916645T>A	uc002jme.1	-	2	469	c.286A>T	c.(286-288)AAC>TAC	p.N96Y	USH1G_uc010wro.1_5'UTR	NM_173477	NP_775748	Q495M9	USH1G_HUMAN	Usher syndrome 1G protein	96					equilibrioception|photoreceptor cell maintenance|sensory perception of sound	actin cytoskeleton				skin(2)	2	all_lung(278;0.172)|Lung NSC(278;0.207)					TGGTAGTCGTTGTCTAGGCAC	0.607													98	12					0	0	1	0	0
ITGB4	3691	broad.mit.edu	37	17	73723752	73723752	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:73723752C>T	uc002jpg.2	+	5	472	c.285C>T	c.(283-285)ACC>ACT	p.T95T	ITGB4_uc002jph.2_Silent_p.T95T|ITGB4_uc010dgo.2_Silent_p.T95T|ITGB4_uc002jpi.3_Silent_p.T95T|ITGB4_uc010dgp.1_Silent_p.T95T|ITGB4_uc002jpj.2_Silent_p.T95T	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	95	Extracellular (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			TTGACACCACCCTGCGGCGCA	0.682													11	3					0	0	1	0	0
PGS1	9489	broad.mit.edu	37	17	76411042	76411042	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:76411042C>G	uc002jvm.2	+	8	1497	c.1485C>G	c.(1483-1485)CAC>CAG	p.H495Q	PGS1_uc010wtt.1_RNA|PGS1_uc010dho.2_RNA|PGS1_uc002jvn.2_Missense_Mutation_p.H208Q|PGS1_uc002jvo.2_RNA|PGS1_uc002jvp.1_Missense_Mutation_p.H208Q	NM_024419	NP_077733	Q32NB8	PGPS1_HUMAN	phosphatidylglycerophosphate synthase 1	495					phospholipid biosynthetic process	endoplasmic reticulum|mitochondrion	ATP binding|CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity				0			BRCA - Breast invasive adenocarcinoma(99;0.00144)|OV - Ovarian serous cystadenocarcinoma(97;0.031)			GGTCAGTTCACCGGGACCTGG	0.607													38	5					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76437281	76437281	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:76437281C>T	uc010dhp.1	-	17	2751	c.2529G>A	c.(2527-2529)AAG>AAA	p.K843K	DNAH17_uc002jvq.2_Silent_p.K128K|DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CCACGAAGTTCCTAGGGGTGG	0.612													20	19					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76506498	76506499	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:76506498_76506499CC>TT	uc010wtu.1	-	1	255_256	c.78_79GG>AA	c.(76-81)GTGGAC>GTAAAC	p.D27N						full-length cDNA clone CS0DJ002YI14 of T cells (Jurkat cell line) Cot 10-normalized of Homo sapiens (human).											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			ACGGCCTTGTCCACGATGTTGC	0.54													75	170					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76539932	76539932	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:76539932T>C	uc002jvv.1	-	13	1751	c.1645A>G	c.(1645-1647)AAA>GAA	p.K549E						RecName: Full=Dynein heavy chain 17, axonemal; AltName: Full=Axonemal beta dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain-like protein 1; AltName: Full=Axonemal dynein heavy chain-like protein 1; AltName: Full=Dynein light chain 2, axonemal;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CCTGGGTGTTTCCTTACTGCA	0.478													194	31					0	0	1	0	0
BAHCC1	57597	broad.mit.edu	37	17	79419781	79419781	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:79419781G>A	uc002kaf.2	+	12	4349	c.4349G>A	c.(4348-4350)CGG>CAG	p.R1450Q	BAHCC1_uc002kae.2_Missense_Mutation_p.R680Q|hsa-mir-3186|MI0014229_5'Flank	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	1450							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			CCTGCACGGCGGGGGCCTGGC	0.677													5	7					0	0	1	0	0
C17orf70	80233	broad.mit.edu	37	17	79517678	79517678	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:79517678G>A	uc002kaq.2	-	3	897	c.842C>T	c.(841-843)CCC>CTC	p.P281L	C17orf70_uc002kao.1_5'Flank|C17orf70_uc010wuq.1_RNA|C17orf70_uc002kap.2_Missense_Mutation_p.P130L	NM_001109760	NP_001103230	Q0VG06	FP100_HUMAN	Fanconi anemia core complex 100 kDa subunit	281					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			ovary(1)|skin(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			GAAGATGACGGGCTCCTCCAG	0.587													44	3					0	0	1	0	0
ASPSCR1	79058	broad.mit.edu	37	17	79974728	79974728	+	Silent	SNP	C	T	T	rs138723012		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:79974728C>T	uc002kcx.2	+	14	1555	c.1458C>T	c.(1456-1458)GCC>GCT	p.A486A	ASPSCR1_uc002kcw.1_Silent_p.A486A|ASPSCR1_uc002kcy.2_Silent_p.A580A|ASPSCR1_uc002kcz.2_Silent_p.A380A|ASPSCR1_uc002kda.2_Silent_p.A434A	NM_024083	NP_076988	Q9BZE9	ASPC1_HUMAN	alveolar soft part sarcoma chromosome region,	486							protein binding		ASPSCR1/TFE3(161)	soft_tissue(118)|kidney(43)|breast(1)	162	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			CATCTGCGGCCGATGTGCTGG	0.657			T	TFE3	alveolar soft part sarcoma								11	32					0	0	1	0	0
TBCD	6904	broad.mit.edu	37	17	80772794	80772794	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:80772794G>A	uc002kfz.2	+	13	1432	c.1302G>A	c.(1300-1302)CCG>CCA	p.P434P	TBCD_uc002kfx.1_Silent_p.P417P|TBCD_uc002kfy.1_Silent_p.P434P	NM_005993	NP_005984	Q9BTW9	TBCD_HUMAN	beta-tubulin cofactor D	434					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity				0	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			TGTTGCTGCCGTCTCGACTCG	0.627													3	27					0	0	1	0	0
ANKRD29	147463	broad.mit.edu	37	18	21229140	21229140	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr18:21229140G>A	uc002kun.2	-	2	196	c.39C>T	c.(37-39)GCC>GCT	p.A13A	ANKRD29_uc002kuo.2_Silent_p.A13A	NM_173505	NP_775776	Q8N6D5	ANR29_HUMAN	ankyrin repeat domain 29	13	ANK 1.									ovary(3)|breast(1)	4	all_cancers(21;5.07e-05)|all_epithelial(16;2.49e-07)|Lung NSC(20;0.00211)|all_lung(20;0.00676)|Colorectal(14;0.0202)|Ovarian(20;0.127)					ATGCAGCATTGGCAAGTGGAG	0.488													8	10					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21526164	21526164	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr18:21526164C>T	uc002kuq.2	+	70	9353	c.9267C>T	c.(9265-9267)GCC>GCT	p.A3089A	LAMA3_uc002kur.2_Silent_p.A3033A|LAMA3_uc002kus.3_Silent_p.A1480A|LAMA3_uc002kut.3_Silent_p.A1424A	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	3089	Laminin G-like 4.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GACTGAGGGCCCGGGAGGGAA	0.493													32	42					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28662324	28662324	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr18:28662324C>A	uc002kwl.3	-	9	1597	c.1143G>T	c.(1141-1143)AAG>AAT	p.K381N	DSC2_uc002kwk.3_Missense_Mutation_p.K381N	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	381	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TCACTAAGTCCTTATCCTCAA	0.318													17	26					1.55795e-14	1.59224e-14	1	1	0
DSG4	147409	broad.mit.edu	37	18	28992935	28992935	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr18:28992935G>A	uc002kwq.2	+	16	2635	c.2500G>A	c.(2500-2502)GAA>AAA	p.E834K	DSG4_uc002kwr.2_Missense_Mutation_p.E853K	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	834	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AAGCTGCATGGAAACTTTAGA	0.433													43	46					0	0	1	0	0
FAM59A	64762	broad.mit.edu	37	18	29867615	29867615	+	Silent	SNP	T	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr18:29867615T>A	uc002kxl.2	-	4	1001	c.945A>T	c.(943-945)GGA>GGT	p.G315G	FAM59A_uc002kxk.1_Silent_p.G315G	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	315	CABIT.									ovary(1)|skin(1)	2						GCCAGCTCTCTCCCTTCACCA	0.537													24	33					0	0	1	0	0
ZNF271	10778	broad.mit.edu	37	18	32887558	32887558	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr18:32887558C>T	uc002kyq.3	+	3	1962	c.970C>T	c.(970-972)CAT>TAT	p.H324Y	ZNF271_uc002kyp.3_Missense_Mutation_p.H324Y|ZNF271_uc002kyr.3_Missense_Mutation_p.H324Y	NR_024565				SubName: Full=cDNA FLJ13394 fis, clone PLACE1001304, highly similar to Homo sapiens zinc finger protein 271 (ZNF271), mRNA;												0						TCTCATTAACCATCAAAAAAT	0.438													16	12					0	0	1	0	0
CELF4	56853	broad.mit.edu	37	18	34854417	34854417	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr18:34854417C>T	uc002lae.2	-	6	1054	c.658G>A	c.(658-660)GGA>AGA	p.G220R	CELF4_uc010dnd.1_Missense_Mutation_p.G219R|CELF4_uc002lag.2_Missense_Mutation_p.G210R|CELF4_uc002laf.2_Missense_Mutation_p.G215R|CELF4_uc002lai.2_Missense_Mutation_p.G205R|CELF4_uc002lah.1_5'Flank|CELF4_uc002laj.1_Missense_Mutation_p.G55E	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	220	Sufficient for RNA-binding and MSE- dependent splicing activity.|RRM 2.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2						GACGAGGCTCCCTGCGGCCGG	0.711													45	90					0	0	1	0	0
NARS	4677	broad.mit.edu	37	18	55274437	55274437	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr18:55274437G>A	uc002lgs.2	-	9	1158	c.930C>T	c.(928-930)GCC>GCT	p.A310A	NARS_uc002lgt.2_Silent_p.A309A|NARS_uc010xea.1_Silent_p.A61A|NARS_uc010xeb.1_RNA|NARS_uc010xec.1_3'UTR|NARS_uc010xed.1_3'UTR	NM_004539	NP_004530	O43776	SYNC_HUMAN	asparaginyl-tRNA synthetase	310					asparaginyl-tRNA aminoacylation	cytosol|soluble fraction	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding				0		Colorectal(73;0.227)			L-Asparagine(DB00174)	CATCTCCCAGGGCTGGGAGGC	0.463													36	46					0	0	1	0	0
CD226	10666	broad.mit.edu	37	18	67614074	67614074	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr18:67614074A>G	uc010dqo.2	-	2	725	c.278T>C	c.(277-279)CTT>CCT	p.L93P	CD226_uc002lkm.3_Missense_Mutation_p.L93P	NM_006566	NP_006557	Q15762	CD226_HUMAN	CD226 molecule precursor	93	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity				0		Esophageal squamous(42;0.129)				CCGAAAGAAAAGAGTCATGTT	0.443													11	20					0	0	1	0	0
RTTN	25914	broad.mit.edu	37	18	67806951	67806951	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr18:67806951A>C	uc002lkp.2	-	21	2740	c.2672T>G	c.(2671-2673)GTT>GGT	p.V891G	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_5'UTR	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	891							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				ACATTCTACAACCTGGGCCAG	0.403													18	23					0	0	1	0	0
RTTN	25914	broad.mit.edu	37	18	67817967	67817967	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr18:67817967T>A	uc002lkp.2	-	15	2000	c.1932A>T	c.(1930-1932)GAA>GAT	p.E644D	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_5'UTR	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	644							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				CACCTAAACATTCCTGtaaaa	0.289													35	33					0	0	1	0	0
GALR1	2587	broad.mit.edu	37	18	74980740	74980740	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr18:74980740G>A	uc002lms.3	+	3	1429	c.932G>A	c.(931-933)AGG>AAG	p.R311K		NM_001480	NP_001471	P47211	GALR1_HUMAN	galanin receptor 1	311	Cytoplasmic (Potential).				digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			lung(1)	1		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		GAAAATTTCAGGAAGGCCTAT	0.448													13	35					0	0	1	0	0
MIER2	54531	broad.mit.edu	37	19	327884	327884	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:327884G>A	uc002lok.1	-	4	358	c.349C>T	c.(349-351)CCA>TCA	p.P117S		NM_017550	NP_060020	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family	117					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTCATGTCTGGGAGGTTCGGG	0.617													18	31					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1042381	1042381	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:1042381G>A	uc002lqw.3	+	6	714	c.483G>A	c.(481-483)ACG>ACA	p.T161T	ABCA7_uc010dsb.1_5'Flank|ABCA7_uc010dsa.2_Silent_p.T161T	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	161	Extracellular (By similarity).				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCTGCTGACGTCACTGCTGC	0.682													4	126					0	0	1	0	0
HMHA1	23526	broad.mit.edu	37	19	1080336	1080336	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:1080336G>A	uc002lqz.1	+	14	2017	c.1786G>A	c.(1786-1788)GAA>AAA	p.E596K	HMHA1_uc010xgd.1_Missense_Mutation_p.E612K|HMHA1_uc010xge.1_Missense_Mutation_p.E436K|HMHA1_uc002lra.1_Missense_Mutation_p.E436K|HMHA1_uc002lrb.1_Missense_Mutation_p.E479K|HMHA1_uc002lrc.1_Missense_Mutation_p.E231K|HMHA1_uc002lrd.1_5'Flank|HMHA1_uc010dsd.1_5'Flank	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	596					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCCCCAGAAGAAGGCGGGTG	0.706													13	30					0	0	1	0	0
SBNO2	22904	broad.mit.edu	37	19	1112039	1112039	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:1112039C>T	uc002lrk.3	-	23	2894	c.2656G>A	c.(2656-2658)GCC>ACC	p.A886T	SBNO2_uc002lrj.3_Missense_Mutation_p.A829T|SBNO2_uc010dse.2_Missense_Mutation_p.A869T|SBNO2_uc010xgj.1_Intron	NM_014963	NP_055778	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 isoform 1	886					macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent						0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GACTCCGTGGCGCGGCGGTCT	0.662													18	51					0	0	1	0	0
APC2	10297	broad.mit.edu	37	19	1462005	1462005	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:1462005C>T	uc002lsr.1	+	14	1890	c.1682C>T	c.(1681-1683)TCT>TTT	p.S561F	APC2_uc002lss.1_Missense_Mutation_p.S143F|APC2_uc002lst.1_Missense_Mutation_p.S561F|APC2_uc002lsu.1_Missense_Mutation_p.S560F|C19orf25_uc010xgn.1_Intron	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	561	ARM 3.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGAATCTGTCTGCACACAGC	0.647													26	39					0	0	1	0	0
TMPRSS9	360200	broad.mit.edu	37	19	2422097	2422097	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:2422097G>A	uc010xgx.1	+	13	2298	c.2298G>A	c.(2296-2298)GGG>GGA	p.G766G		NM_182973	NP_892018	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	766	Extracellular (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGTCCCGGGGGCCACACCCA	0.657													33	54					0	0	1	0	0
PLIN4	729359	broad.mit.edu	37	19	4512515	4512515	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:4512515C>T	uc002mar.1	-	3	1415	c.1415G>A	c.(1414-1416)GGC>GAC	p.G472D	PLIN4_uc010dub.1_5'Flank	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	472	27 X 33 AA approximate tandem repeat.|12.					lipid particle|plasma membrane					0						GTCCAGGCCGCCCTGGACGGC	0.597													61	81					0	0	1	0	0
PRR22	163154	broad.mit.edu	37	19	5784033	5784033	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:5784033G>A	uc002mdb.1	-	1	578	c.219C>T	c.(217-219)TTC>TTT	p.F73F	PRR22_uc010xiv.1_Silent_p.F75F	NM_153359	NP_699190	Q8IZ63	PRR22_HUMAN	proline rich 22 isoform 2	73											0						TGCGGGGGTCGAAGAAGCACC	0.697													4	13					0	0	1	0	0
RANBP3	8498	broad.mit.edu	37	19	5923822	5923823	+	Splice_Site	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:5923822_5923823CC>TT	uc002mdw.2	-	12	1326	c.1099_splice	c.e12+1	p.E367_splice	RANBP3_uc002mdv.2_Splice_Site_p.E86_splice|RANBP3_uc002mdx.2_Splice_Site_p.E362_splice|RANBP3_uc002mdy.2_Splice_Site_p.E299_splice|RANBP3_uc002mdz.2_Splice_Site_p.E294_splice|RANBP3_uc010duq.2_Splice_Site_p.E272_splice|RANBP3_uc002mea.2_Splice_Site_p.E234_splice|RANBP3_uc010xix.1_Splice_Site_p.E239_splice	NM_007322	NP_015561	Q9H6Z4	RANB3_HUMAN	RAN binding protein 3 isoform RANBP3-d						intracellular transport|protein transport	cytoplasm|nucleus	Ran GTPase binding			breast(1)	1						CGCTAACATACCTTTCTCAGGG	0.589													19	21					0	0	1	0	0
SLC25A23	79085	broad.mit.edu	37	19	6452425	6452425	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:6452425C>T	uc002mex.1	-	8	1111	c.969G>A	c.(967-969)AGG>AGA	p.R323R	SLC25A23_uc002mev.2_RNA|SLC25A23_uc010xjd.1_Intron	NM_024103	NP_077008	Q9BV35	SCMC3_HUMAN	solute carrier family 25, member 23	323	Solcar 2.|Mitochondrial matrix (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			ovary(1)|pancreas(1)	2						CCAGGATACGCCTGGCGCAGT	0.652													15	12					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6678293	6678294	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:6678293_6678294CC>TT	uc002mfm.2	-	40	4781_4782	c.4719_4720GG>AA	c.(4717-4722)TCGGAT>TCAAAT	p.D1574N	C3_uc002mfl.2_Missense_Mutation_p.D310N	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1574	NTR.				complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TGCACCTCATCCGAGCCTGGAG	0.599													25	36					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6712535	6712535	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:6712535A>C	uc002mfm.2	-	10	1165	c.1103T>G	c.(1102-1104)ATG>AGG	p.M368R		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	368					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GTCAAAGGGCATTCCTGGTTT	0.627													78	137					0	0	1	0	0
GPR108	56927	broad.mit.edu	37	19	6736626	6736626	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:6736626C>T	uc002mfp.2	-	2	263	c.217G>A	c.(217-219)GAG>AAG	p.E73K	GPR108_uc002mfn.2_5'UTR|GPR108_uc002mfo.3_5'UTR|GPR108_uc010duw.2_RNA	NM_001080452	NP_001073921	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108 isoform 1	73						integral to membrane					0						TCTTCTGCCTCCCGGAGGCCC	0.448											OREG0025202	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	20					0	0	1	0	0
TRIP10	9322	broad.mit.edu	37	19	6750333	6750333	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:6750333C>T	uc002mfs.2	+	13	1492	c.1426C>T	c.(1426-1428)CTT>TTT	p.L476F	TRIP10_uc010dux.1_Missense_Mutation_p.L420F|TRIP10_uc002mfr.2_Missense_Mutation_p.L420F|TRIP10_uc010duy.2_RNA|TRIP10_uc010duz.2_Missense_Mutation_p.L239F	NM_004240	NP_004231	Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	476	Interaction with CDC42.|Interaction with PDE6G (By similarity).|REM.|Required for interaction with FASLG and localization to lysosomes.				actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding			ovary(1)	1						AAGTCGAGTCCTTAGCAACCG	0.667													66	76					0	0	1	0	0
INSR	3643	broad.mit.edu	37	19	7168027	7168027	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:7168027G>A	uc002mgd.1	-	7	1671	c.1562C>T	c.(1561-1563)CCC>CTC	p.P521L	INSR_uc002mge.1_Missense_Mutation_p.P521L|INSR_uc002mgf.2_Missense_Mutation_p.P521L	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	521					activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GAAGTCGGGGGGCCAGTACGG	0.478													12	35					0	0	1	0	0
PNPLA6	10908	broad.mit.edu	37	19	7614987	7614987	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:7614987C>T	uc010xjq.1	+	16	2025	c.1830C>T	c.(1828-1830)TCC>TCT	p.S610S	PNPLA6_uc002mgq.1_Silent_p.S562S|PNPLA6_uc010xjp.1_Silent_p.S536S|PNPLA6_uc002mgr.1_Silent_p.S562S|PNPLA6_uc002mgs.2_Silent_p.S601S	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	601	cNMP 2.|Cytoplasmic (Potential).				cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3						TCTCCAAGTCCGACTTCTATG	0.622													49	73					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7810698	7810698	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:7810698A>G	uc002mht.2	-	4	521	c.454T>C	c.(454-456)TGG>CGG	p.W152R	CD209_uc010xju.1_Intron|CD209_uc010dvp.2_Missense_Mutation_p.W128R|CD209_uc002mhr.2_Missense_Mutation_p.W128R|CD209_uc002mhs.2_Missense_Mutation_p.W128R|CD209_uc002mhu.2_Missense_Mutation_p.W152R|CD209_uc010dvq.2_Missense_Mutation_p.W152R|CD209_uc002mhq.2_Missense_Mutation_p.W152R|CD209_uc002mhv.2_Missense_Mutation_p.W128R|CD209_uc002mhx.2_Missense_Mutation_p.W108R|CD209_uc002mhw.2_Missense_Mutation_p.W108R|CD209_uc010dvr.2_Intron	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	152	Extracellular (Probable).|7 X approximate tandem repeats.|3.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						GCCTTCAGCCAGGTCAGCTCC	0.557													7	173					0	0	1	0	0
CLEC4M	10332	broad.mit.edu	37	19	7831586	7831586	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:7831586G>A	uc002mih.2	+	6	878	c.760G>A	c.(760-762)GGA>AGA	p.G254R	CLEC4M_uc010xjv.1_3'UTR|CLEC4M_uc002mhy.2_3'UTR|CLEC4M_uc010xjw.1_Missense_Mutation_p.G210R|CLEC4M_uc010dvt.2_Missense_Mutation_p.G231R|CLEC4M_uc010dvs.2_Missense_Mutation_p.G253R|CLEC4M_uc010xjx.1_Missense_Mutation_p.G226R|CLEC4M_uc002mhz.2_Missense_Mutation_p.G185R|CLEC4M_uc002mic.2_Missense_Mutation_p.G249R|CLEC4M_uc002mia.2_Missense_Mutation_p.G141R	NM_001144910	NP_001138382	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M isoform	277	Extracellular (Probable).|C-type lectin.				cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			pancreas(1)	1						ATTCTTCCAAGGAAACTGTTA	0.557													30	59					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8186265	8186265	+	Missense_Mutation	SNP	C	T	T	rs142237067	byFrequency	TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:8186265C>T	uc002mjf.2	-	24	3109	c.3088G>A	c.(3088-3090)GAC>AAC	p.D1030N		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1030	EGF-like 13; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CGACACTCGTCGATATCTGTG	0.647													7	9					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8188379	8188379	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:8188379G>A	uc002mjf.2	-	23	3072	c.3051C>T	c.(3049-3051)TTC>TTT	p.F1017F		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1017	EGF-like 12; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CATCCAGGGCGAAGCCCCCCG	0.597													14	17					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8620608	8620608	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:8620608G>A	uc002mkg.2	-	2	190	c.76C>T	c.(76-78)CCC>TCC	p.P26S	MYO1F_uc002mkh.2_Missense_Mutation_p.P26S|MYO1F_uc010xkf.1_Missense_Mutation_p.P26S	NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	26	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						GTGATCTGGGGAAGAAGCACC	0.642													21	35					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8661987	8661987	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:8661987C>T	uc002mkj.1	-	8	1198	c.924G>A	c.(922-924)GGG>GGA	p.G308G	ADAMTS10_uc002mkk.1_5'UTR	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	308	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						CCAGGGACTTCCCGGCATGGT	0.582													64	76					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9013857	9013857	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:9013857G>A	uc002mkp.2	-	33	38737	c.38533C>T	c.(38533-38535)CCC>TCC	p.P12845S	MUC16_uc010xki.1_5'Flank	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12847	Extracellular (Potential).			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTAGGGCTGGGGAGGGAGGAT	0.478													14	20					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9015342	9015342	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:9015342G>A	uc002mkp.2	-	30	38450	c.38246C>T	c.(38245-38247)TCT>TTT	p.S12749F	MUC16_uc010xki.1_5'Flank	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12751	SEA 5.|Extracellular (Potential).			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCTGCAGCCAGAGTACAGAGG	0.522													73	115					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9057032	9057032	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:9057032G>A	uc002mkp.2	-	3	30618	c.30414C>T	c.(30412-30414)TCC>TCT	p.S10138S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10140	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTTCAGCCATGGAAGAGGGAG	0.458													7	6					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9058672	9058672	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:9058672G>T	uc002mkp.2	-	3	28978	c.28774C>A	c.(28774-28776)CAG>AAG	p.Q9592K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9594	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGATGTCCTGGGAGGTTCTG	0.522													7	12					1.12685e-05	1.135e-05	1	1	0
MUC16	94025	broad.mit.edu	37	19	9059493	9059493	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:9059493G>A	uc002mkp.2	-	3	28157	c.27953C>T	c.(27952-27954)ACT>ATT	p.T9318I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9320	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGAGACCTCAGTAGTAGCACC	0.512													31	46					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9063255	9063255	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:9063255G>A	uc002mkp.2	-	3	24395	c.24191C>T	c.(24190-24192)TCC>TTC	p.S8064F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8066	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCCAGAACTGGAGGTCCCCAC	0.473													17	28					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9065398	9065398	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:9065398A>T	uc002mkp.2	-	3	22252	c.22048T>A	c.(22048-22050)TCC>ACC	p.S7350T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7352	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATTACCAAGGAGGGAGTGGTT	0.488													13	21					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9066340	9066340	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:9066340G>A	uc002mkp.2	-	3	21310	c.21106C>T	c.(21106-21108)CCT>TCT	p.P7036S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7038	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GACCCAGAAGGACCTGTTTGA	0.478													38	59					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9082600	9082600	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:9082600T>C	uc002mkp.2	-	1	9419	c.9215A>G	c.(9214-9216)CAG>CGG	p.Q3072R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3073	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGCTGAAGTCTGAAGATGCAC	0.493													42	48					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9090133	9090133	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:9090133G>A	uc002mkp.2	-	1	1886	c.1682C>T	c.(1681-1683)TCT>TTT	p.S561F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	561	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGAGGGAACAGAAGTGGTGAT	0.522													19	28					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9091052	9091052	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:9091052C>T	uc002mkp.2	-	1	967	c.763G>A	c.(763-765)GAA>AAA	p.E255K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	255	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGAATCAGTTCCAGGCTTGTT	0.478													13	18					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9091598	9091598	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:9091598C>T	uc002mkp.2	-	1	421	c.217G>A	c.(217-219)GGA>AGA	p.G73R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	73	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGGTTCTTCCCACAACCGAA	0.522													34	56					0	0	1	0	0
OR7D4	125958	broad.mit.edu	37	19	9325456	9325456	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:9325456C>T	uc002mla.1	-	1	58	c.58G>A	c.(58-60)GAT>AAT	p.D20N		NM_001005191	NP_001005191	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						AGTTCAGGATCATCTGAGAGT	0.507													34	52					0	0	1	0	0
ZNF699	374879	broad.mit.edu	37	19	9406613	9406613	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:9406613G>A	uc002mlc.1	-	5	1467	c.1467C>T	c.(1465-1467)TCC>TCT	p.S489S		NM_198535	NP_940937	Q32M78	ZN699_HUMAN	zinc finger protein 699	489	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTTCGGTGAGGGATGAGGAAC	0.443													17	30					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9585962	9585962	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:9585962G>A	uc002mlp.1	-	3	238	c.28C>T	c.(28-30)CAG>TAG	p.Q10*	ZNF560_uc010dwr.1_5'UTR	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	10					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						CTGCATACCTGATAACAATTT	0.408													24	21					0	0	1	0	0
ZNF561	93134	broad.mit.edu	37	19	9721471	9721471	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:9721471G>A	uc002mlu.2	-	6	1071	c.866C>T	c.(865-867)TCC>TTC	p.S289F	ZNF561_uc010dwu.2_Missense_Mutation_p.S220F|ZNF561_uc010xkr.1_Missense_Mutation_p.S153F	NM_152289	NP_689502	Q8N587	ZN561_HUMAN	zinc finger protein 561	289	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATTTCTAAAGGATCTTCCACA	0.358													22	35					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10112322	10112322	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:10112322T>A	uc002mmq.1	-	8	1074	c.988A>T	c.(988-990)ACC>TCC	p.T330S		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	330	Nonhelical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			CCCAGCTCGGTTCCACTGTCA	0.562											OREG0025228	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	42					0	0	1	0	0
SLC44A2	57153	broad.mit.edu	37	19	10747048	10747048	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:10747048A>T	uc002mpf.2	+	15	1422	c.1283A>T	c.(1282-1284)CAG>CTG	p.Q428L	SLC44A2_uc002mpe.3_Missense_Mutation_p.Q426L|SLC44A2_uc002mpg.1_Missense_Mutation_p.Q148L|SLC44A2_uc002mph.2_5'UTR	NM_020428	NP_065161	Q8IWA5	CTL2_HUMAN	solute carrier family 44, member 2 isoform 1	428	Extracellular (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			ovary(1)	1			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	GCCCGTTGCCAGTTCGCCTTC	0.592													42	53					0	0	1	0	0
DNM2	1785	broad.mit.edu	37	19	10940945	10940945	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:10940945C>T	uc002mps.1	+	20	2598	c.2434C>T	c.(2434-2436)CGG>TGG	p.R812W	DNM2_uc010dxk.2_Intron|DNM2_uc002mpt.1_Missense_Mutation_p.R812W|DNM2_uc002mpv.1_Missense_Mutation_p.R808W|DNM2_uc002mpu.1_Missense_Mutation_p.R808W|DNM2_uc010dxl.1_Missense_Mutation_p.R812W|DNM2_uc002mpw.2_Missense_Mutation_p.R541W|DNM2_uc002mpx.1_Missense_Mutation_p.R168W	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	812	Pro-rich.				G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			AATCCCATCCCGGCCTGGACC	0.697													68	132					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11097627	11097628	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:11097627_11097628CC>TT	uc002mqf.3	+	5	1091_1092	c.807_808CC>TT	c.(805-810)CCCCCC>CCTTCC	p.P270S	SMARCA4_uc010dxp.2_Missense_Mutation_p.P270S|SMARCA4_uc010dxo.2_Missense_Mutation_p.P270S|SMARCA4_uc002mqg.1_Missense_Mutation_p.P270S|SMARCA4_uc010dxq.2_Missense_Mutation_p.P270S|SMARCA4_uc010dxr.2_Missense_Mutation_p.P270S|SMARCA4_uc002mqj.3_Missense_Mutation_p.P270S|SMARCA4_uc010dxs.2_Missense_Mutation_p.P270S|SMARCA4_uc002mqe.2_Missense_Mutation_p.P270S	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	270	Necessary for interaction with SS18L1/CREST (By similarity).				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.P270fs*16(1)|p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CGGGCGTGCCCCCCGGGATGCC	0.624			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				35	38					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11227604	11227604	+	Missense_Mutation	SNP	G	A	A	rs137929307		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:11227604G>A	uc002mqk.3	+	12	1943	c.1775G>A	c.(1774-1776)GGG>GAG	p.G592E	LDLR_uc010xlk.1_Missense_Mutation_p.G592E|LDLR_uc010xll.1_Missense_Mutation_p.G551E|LDLR_uc010xlm.1_Missense_Mutation_p.G445E|LDLR_uc010xln.1_Missense_Mutation_p.G465E|LDLR_uc010xlo.1_Missense_Mutation_p.G424E	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	592	LDL-receptor class B 5.|Extracellular (Potential).		G -> E (in FH; Sicily).		cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	GATGTCAACGGGGGCAACCGG	0.537													79	128					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11240222	11240222	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:11240222T>A	uc002mqk.3	+	17	2591	c.2423T>A	c.(2422-2424)CTT>CAT	p.L808H	LDLR_uc010xlk.1_Missense_Mutation_p.L808H|LDLR_uc010xll.1_Missense_Mutation_p.L767H|LDLR_uc010xlm.1_Missense_Mutation_p.L661H|LDLR_uc010xln.1_Missense_Mutation_p.L630H|LDLR_uc010xlo.1_Missense_Mutation_p.L640H|LDLR_uc010dxu.2_5'UTR	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	808	Helical; (Potential).				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	GGGGTCTTCCTTCTATGGAAG	0.552													47	37					0	0	1	0	0
CD97	976	broad.mit.edu	37	19	14507996	14507996	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:14507996C>T	uc002myl.2	+	6	709	c.586C>T	c.(586-588)CCG>TCG	p.P196S	CD97_uc002mym.2_Intron|CD97_uc002myn.2_Intron	NM_078481	NP_510966	P48960	CD97_HUMAN	CD97 antigen isoform 1 precursor	196	Extracellular (Potential).|EGF-like 4; calcium-binding (Potential).				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4						GCAACCGATTCCGGGGTCCCC	0.587													49	93					0	0	1	0	0
PTGER1	5731	broad.mit.edu	37	19	14583464	14583464	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:14583464T>G	uc002mys.2	-	3	1235	c.1117A>C	c.(1117-1119)AAG>CAG	p.K373Q		NM_000955	NP_000946	P34995	PE2R1_HUMAN	prostaglandin E receptor 1, subtype EP1	373	Cytoplasmic (Potential).					integral to plasma membrane	prostaglandin E receptor activity				0					Alprostadil(DB00770)|Bimatoprost(DB00905)|Bupivacaine(DB00297)|Carboprost Tromethamine(DB00429)	GGGCCGCCCTTGGCTCCGGCC	0.697													3	4					0	0	1	0	0
OR7C2	26658	broad.mit.edu	37	19	15052767	15052767	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:15052767C>T	uc010xoc.1	+	1	467	c.467C>T	c.(466-468)TCC>TTC	p.S156F		NM_012377	NP_036509	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Ovarian(108;0.203)					GTCATGGGTTCCTTGCTTGAG	0.522													75	110					0	0	1	0	0
OR7C2	26658	broad.mit.edu	37	19	15053175	15053176	+	Missense_Mutation	DNP	GG	TA	TA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:15053175_15053176GG>TA	uc010xoc.1	+	1	875_876	c.875_876GG>TA	c.(874-876)AGG>ATA	p.R292I		NM_012377	NP_036509	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C,	292	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Ovarian(108;0.203)					TACAGCCTGAGGAACAAGGACA	0.53													37	64					0	0	1	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15586350	15586350	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:15586350C>T	uc002nbf.3	-	2	1264	c.1131G>A	c.(1129-1131)CTG>CTA	p.L377L	PGLYRP2_uc002nbg.3_Silent_p.L377L	NM_052890	NP_443122	Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2 precursor	377					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)	3						CTTCCTCACCCAGGAAGGCCT	0.507													75	122					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15757899	15757899	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:15757899C>T	uc002nbj.2	+	4	431	c.381C>T	c.(379-381)TTC>TTT	p.F127F	CYP4F3_uc010xok.1_Silent_p.F127F|CYP4F3_uc010xol.1_Silent_p.F127F|CYP4F3_uc010xom.1_5'UTR|CYP4F3_uc002nbk.2_Silent_p.F127F|CYP4F3_uc010xon.1_5'Flank	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	127					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						TCTACAGCTTCCTGAAGCCCT	0.582													30	63					0	0	1	0	0
CYP4F12	66002	broad.mit.edu	37	19	15795970	15795970	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:15795970G>A	uc002nbl.2	+	9	1139	c.1078G>A	c.(1078-1080)GAG>AAG	p.E360K		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					GGAGGTGCAAGAGCTTCTGAA	0.572													3	59					0	0	1	0	0
EPS15L1	58513	broad.mit.edu	37	19	16503152	16503152	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:16503152G>A	uc002ndz.1	-	19	2072	c.2066C>T	c.(2065-2067)TCG>TTG	p.S689L	EPS15L1_uc002ndx.2_Missense_Mutation_p.S689L|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpe.1_Missense_Mutation_p.S579L|EPS15L1_uc010xpf.1_Missense_Mutation_p.S592L|EPS15L1_uc002nea.1_Missense_Mutation_p.S689L|EPS15L1_uc010eah.1_Missense_Mutation_p.S691L	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	689	15 X 3 AA repeats of D-P-F.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						GAATGGATCCGAGGTAAATGG	0.537													40	49					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16860284	16860285	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:16860284_16860285CC>TT	uc002neu.3	+	6	1253_1254	c.831_832CC>TT	c.(829-834)GTCCTC>GTTTTC	p.L278F	NWD1_uc002net.3_Missense_Mutation_p.L143F|NWD1_uc002nev.3_Missense_Mutation_p.L72F			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	278	WD 1.						ATP binding			skin(3)|ovary(2)|pancreas(2)	7						ATCACCAGGTCCTCACACGCCT	0.604													14	29					0	0	1	0	0
F2RL3	9002	broad.mit.edu	37	19	17000832	17000832	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:17000832C>T	uc002nfa.2	+	2	733	c.558C>T	c.(556-558)GCC>GCT	p.A186A		NM_003950	NP_003941	Q96RI0	PAR4_HUMAN	coagulation factor II (thrombin) receptor-like 3	186	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation|positive regulation of release of sequestered calcium ion into cytosol	extracellular region|integral to plasma membrane	thrombin receptor activity				0						GGGCCCGCGCCCTGCGTGGCC	0.711													10	6					0	0	1	0	0
USHBP1	83878	broad.mit.edu	37	19	17370460	17370460	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:17370460G>A	uc002nfs.1	-	6	963	c.850C>T	c.(850-852)CAG>TAG	p.Q284*	USHBP1_uc002nfr.1_5'Flank|USHBP1_uc002nft.1_RNA|USHBP1_uc010xpk.1_Nonsense_Mutation_p.Q220*|USHBP1_uc010eam.1_Nonsense_Mutation_p.Q212*	NM_031941	NP_114147	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	284							PDZ domain binding			ovary(1)	1						CTGAGGGGCTGGTTGGGAAGA	0.582													66	97					0	0	1	0	0
TMEM59L	25789	broad.mit.edu	37	19	18729265	18729265	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:18729265C>T	uc002njy.3	+	7	950	c.863C>T	c.(862-864)ACC>ATC	p.T288I		NM_012109	NP_036241	Q9UK28	TM59L_HUMAN	brain-specific membrane-anchored protein	288	Helical; (Potential).					Golgi membrane|integral to membrane|membrane fraction				ovary(2)|skin(2)	4						AGCTGCTCCACCCTGGTGACC	0.677													11	10					0	0	1	0	0
TMEM161A	54929	broad.mit.edu	37	19	19243163	19243163	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:19243163G>A	uc002nlg.2	-	5	471	c.441C>T	c.(439-441)TCC>TCT	p.S147S	TMEM161A_uc010eca.2_RNA|TMEM161A_uc002nlh.2_Silent_p.S122S|TMEM161A_uc002nli.2_Intron|TMEM161A_uc002nlj.2_Silent_p.S22S	NM_017814	NP_060284	Q9NX61	T161A_HUMAN	transmembrane protein 161A precursor	147	Helical; (Potential).				cellular response to oxidative stress|cellular response to UV|negative regulation of apoptosis|positive regulation of DNA repair|response to retinoic acid	integral to membrane				breast(2)	2			OV - Ovarian serous cystadenocarcinoma(5;1.19e-05)|Epithelial(12;0.0011)			AAGGATACATGGAGAAGGTCA	0.542													52	62					0	0	1	0	0
ZNF626	199777	broad.mit.edu	37	19	20808006	20808006	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:20808006T>C	uc002npb.1	-	4	827	c.677A>G	c.(676-678)GAG>GGG	p.E226G	ZNF626_uc002npc.1_Missense_Mutation_p.E150G	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						GTAGGGTTTCTCTCCAGTATG	0.393													3	61					0	0	1	0	0
ZNF681	148213	broad.mit.edu	37	19	23926923	23926923	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:23926923G>A	uc002nrk.3	-	4	1571	c.1429C>T	c.(1429-1431)CCC>TCC	p.P477S	ZNF681_uc002nrl.3_Missense_Mutation_p.P408S|ZNF681_uc002nrj.3_Missense_Mutation_p.P408S	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	477					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				CATTTGTAGGGTTTCTCTCCA	0.363													27	57					0	0	1	0	0
ZNF254	9534	broad.mit.edu	37	19	24309789	24309789	+	Silent	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:24309789A>G	uc002nru.2	+	4	1121	c.987A>G	c.(985-987)AAA>AAG	p.K329K	ZNF254_uc010xrk.1_Silent_p.K244K	NM_203282	NP_975011	O75437	ZN254_HUMAN	zinc finger protein 254	329	C2H2-type 5.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				AATGTGGCAAAGCATTTATAT	0.403													4	31					0	0	1	0	0
ZNF254	9534	broad.mit.edu	37	19	24310004	24310004	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:24310004T>C	uc002nru.2	+	4	1336	c.1202T>C	c.(1201-1203)GTT>GCT	p.V401A	ZNF254_uc010xrk.1_Missense_Mutation_p.V316A	NM_203282	NP_975011	O75437	ZN254_HUMAN	zinc finger protein 254	401					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				ATAATTCATGTTGGAGAGAAA	0.338													2	9					0	0	1	0	0
ZNF254	9534	broad.mit.edu	37	19	24310230	24310230	+	Silent	SNP	C	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:24310230C>A	uc002nru.2	+	4	1562	c.1428C>A	c.(1426-1428)ACC>ACA	p.T476T	ZNF254_uc010xrk.1_Silent_p.T391T	NM_203282	NP_975011	O75437	ZN254_HUMAN	zinc finger protein 254	476	C2H2-type 10.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				GGTCCTCAACCCTAACTAGAC	0.393													5	55					0.184627	0.18476	1	1	0
LRP3	4037	broad.mit.edu	37	19	33698422	33698422	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:33698422C>T	uc010edh.2	+	7	2347	c.2254C>T	c.(2254-2256)CCG>TCG	p.P752S	LRP3_uc002nuk.3_Missense_Mutation_p.P626S	NM_002333	NP_002324	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein	752	Cytoplasmic (Potential).|Poly-Pro.				receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			pancreas(2)|ovary(1)	3	Esophageal squamous(110;0.137)					CAGGAACCCCCCGCCCCCCTG	0.697													6	5					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35827096	35827096	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:35827096G>A	uc010edt.2	+	4	647	c.570G>A	c.(568-570)TCG>TCA	p.S190S	CD22_uc010xst.1_Silent_p.S18S|CD22_uc010edu.2_Silent_p.S190S|CD22_uc010edv.2_Silent_p.S190S|CD22_uc002nzb.3_Silent_p.S190S|CD22_uc010edx.2_5'Flank	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	190	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	CTGTCACCTCGACCTCCTTGA	0.547													36	45					0	0	1	0	0
TYROBP	7305	broad.mit.edu	37	19	36398661	36398661	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:36398661A>C	uc002ocm.2	-	2	121	c.65T>G	c.(64-66)CTC>CGC	p.L22R	TYROBP_uc002ocn.2_Missense_Mutation_p.L22R	NM_003332	NP_003323	O43914	TYOBP_HUMAN	TYRO protein tyrosine kinase binding protein	22	Extracellular (Potential).				axon guidance|cell junction assembly|cellular defense response|intracellular signal transduction|regulation of immune response	integral to plasma membrane|intracellular	identical protein binding|receptor signaling protein activity				0	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GACAGGACGGAGACCTGAGGA	0.597													19	16					0	0	1	0	0
ZNF569	148266	broad.mit.edu	37	19	37917218	37917218	+	Silent	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:37917218A>G	uc002ogi.2	-	4	636	c.78T>C	c.(76-78)GAT>GAC	p.D26D	ZNF569_uc002ogh.2_Intron|ZNF569_uc002ogj.2_Silent_p.D50D	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	26	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCTGAGCAGGATCCAATCTCT	0.393													33	40					0	0	1	0	0
ZNF793	390927	broad.mit.edu	37	19	38024238	38024238	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:38024238C>T	uc010efm.2	+	7	613	c.171C>T	c.(169-171)ATC>ATT	p.I57I	ZNF793_uc010xts.1_Silent_p.I57I|ZNF793_uc010efo.2_Silent_p.I57I	NM_001013659	NP_001013681	Q6ZN11	ZN793_HUMAN	zinc finger protein 793	57	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CAGATGTGATCCTCAGACTGG	0.527													54	54					0	0	1	0	0
ZNF540	163255	broad.mit.edu	37	19	38103100	38103100	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:38103100G>A	uc002ogq.2	+	5	1251	c.919G>A	c.(919-921)GTT>ATT	p.V307I	ZNF540_uc002ogu.2_Missense_Mutation_p.V307I|ZNF540_uc010efq.2_Missense_Mutation_p.V275I	NM_152606	NP_689819	Q8NDQ6	ZN540_HUMAN	zinc finger protein 540	307	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATGTGGAAAAGTTTTTCAACT	0.303													8	17					0	0	1	0	0
ZNF780A	284323	broad.mit.edu	37	19	40580675	40580675	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:40580675T>A	uc002omy.2	-	6	1899	c.1674A>T	c.(1672-1674)GAA>GAT	p.E558D	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Missense_Mutation_p.E558D|ZNF780A_uc010xvh.1_Missense_Mutation_p.E559D	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	558	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					ATTCCTTACATTCAAAGGGTT	0.383													66	78					0	0	1	0	0
HIPK4	147746	broad.mit.edu	37	19	40895518	40895518	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:40895518C>T	uc002onp.2	-	1	577	c.292G>A	c.(292-294)GAG>AAG	p.E98K		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	98	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			TTCTGGAACTCGAAAAGGTTT	0.597													40	38					0	0	1	0	0
PRX	57716	broad.mit.edu	37	19	40902257	40902257	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:40902257G>A	uc002onr.2	-	7	2271	c.2002C>T	c.(2002-2004)CCT>TCT	p.P668S	PRX_uc002onq.2_Missense_Mutation_p.P529S|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	668	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGCATTTTAGGGAGTTTCATC	0.572													55	75					0	0	1	0	0
CYP2A13	1553	broad.mit.edu	37	19	41594481	41594481	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:41594481G>A	uc002opt.2	+	1	114	c.105G>A	c.(103-105)CCG>CCA	p.P35P		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	35					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	AGCTGCCTCCGGGACCCACCC	0.582													40	54					0	0	1	0	0
CEACAM4	1089	broad.mit.edu	37	19	42133291	42133291	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:42133291G>A	uc002orh.1	-	1	152	c.41C>T	c.(40-42)CCC>CTC	p.P14L	CEACAM4_uc010xwd.1_Missense_Mutation_p.P14L	NM_001817	NP_001808	O75871	CEAM4_HUMAN	carcinoembryonic antigen-related cell adhesion	14						integral to plasma membrane|membrane fraction					0						CCCCTGCCAGGGCCTGTGCCC	0.652													17	24					0	0	1	0	0
LYPD4	147719	broad.mit.edu	37	19	42342965	42342965	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:42342965G>A	uc002orp.1	-	3	1185	c.201C>T	c.(199-201)TTC>TTT	p.F67F	LYPD4_uc002orq.1_Intron	NM_173506	NP_775777	Q6UWN0	LYPD4_HUMAN	LY6/PLAUR domain containing 4 precursor	67						anchored to membrane|plasma membrane				ovary(1)	1						CTGTCTCAATGAACACTAGCG	0.488													76	79					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42794644	42794645	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:42794644_42794645CC>TT	uc002otf.1	+	10	1764_1765	c.1724_1725CC>TT	c.(1723-1725)CCC>CTT	p.P575L		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	575	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				CGGCCCCCACCCCCTGGGGCTG	0.673			T	DUX4	soft tissue sarcoma								23	33					0	0	1	0	0
ZNF180	7733	broad.mit.edu	37	19	44981615	44981615	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:44981615G>A	uc002ozf.3	-	5	1365	c.1083C>T	c.(1081-1083)TCC>TCT	p.S361S	ZNF180_uc002ozh.3_Silent_p.S18S|ZNF180_uc002ozi.3_Silent_p.S334S|ZNF180_uc002ozg.3_Silent_p.S360S|ZNF180_uc010ejm.2_Silent_p.S336S	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	361	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				TCCAGCTGAAGGATTTCCCAC	0.413													36	58					0	0	1	0	0
CBLC	23624	broad.mit.edu	37	19	45281316	45281316	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:45281316C>T	uc002ozs.2	+	1	191	c.128C>T	c.(127-129)TCG>TTG	p.S43L	CBLC_uc010ejt.2_Missense_Mutation_p.S43L	NM_012116	NP_036248	Q9ULV8	CBLC_HUMAN	Cas-Br-M (murine) ecotropic retroviral	43	4H.|Cbl-PTB.				cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(1)|skin(1)	6	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				AGTCCCCCTTCGCTGCGGGAC	0.542			M		AML								21	39					0	0	1	0	0
PVRL2	5819	broad.mit.edu	37	19	45389394	45389394	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:45389394C>T	uc002ozw.1	+	8	1655	c.1265C>T	c.(1264-1266)TCC>TTC	p.S422F		NM_001042724	NP_001036189	Q92692	PVRL2_HUMAN	poliovirus receptor related 2 isoform delta	422	Cytoplasmic (Potential).				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		CTACAGCCCTCCCAGCTCTTC	0.662													17	27					0	0	1	0	0
APOC1	341	broad.mit.edu	37	19	45422430	45422430	+	Silent	SNP	G	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:45422430G>T	uc002pac.1	+	5	447	c.195G>T	c.(193-195)CGG>CGT	p.R65R	APOC1_uc002pad.1_Silent_p.R65R|APOC1_uc002pae.1_Silent_p.R65R|APOC1_uc002paf.1_RNA	NM_001645	NP_001636	P02654	APOC1_HUMAN	apolipoprotein C-I precursor	65					cholesterol efflux|chylomicron remnant clearance|high-density lipoprotein particle remodeling|lipoprotein metabolic process|negative regulation of cholesterol transport|negative regulation of fatty acid biosynthetic process|negative regulation of lipoprotein lipase activity|negative regulation of phosphatidylcholine catabolic process|negative regulation of receptor-mediated endocytosis|negative regulation of very-low-density lipoprotein particle clearance|phospholipid efflux|positive regulation of cholesterol esterification|very-low-density lipoprotein particle assembly|very-low-density lipoprotein particle clearance	chylomicron|endoplasmic reticulum|high-density lipoprotein particle|very-low-density lipoprotein particle	fatty acid binding|phosphatidylcholine binding|phosphatidylcholine-sterol O-acyltransferase activator activity|phospholipase inhibitor activity				0	Lung NSC(12;0.0018)|all_lung(12;0.00481)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00327)|Epithelial(262;0.174)		CTCCCCACAGGGAGTGGTTTT	0.522													150	163					7.77156e-87	8.0191e-87	1	1	0
BLOC1S3	388552	broad.mit.edu	37	19	45683139	45683139	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:45683139G>A	uc002pax.3	+	2	681	c.585G>A	c.(583-585)GAG>GAA	p.E195E	TRAPPC6A_uc002pav.2_5'Flank|TRAPPC6A_uc002paw.2_5'Flank	NM_212550	NP_997715	Q6QNY0	BL1S3_HUMAN	biogenesis of lysosomal organelles complex-1,	195					cellular membrane organization|eye development|melanosome organization|platelet activation|platelet dense granule organization|post-Golgi vesicle-mediated transport	BLOC-1 complex	identical protein binding				0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00863)|GBM - Glioblastoma multiforme(486;0.231)		CCGAGCCTGAGAAAGACCCGG	0.667									Hermansky-Pudlak_syndrome				24	31					0	0	1	0	0
IGFL2	147920	broad.mit.edu	37	19	46664137	46664137	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:46664137A>G	uc010xxv.1	+	3	376	c.340A>G	c.(340-342)AGC>GGC	p.S114G	IGFL2_uc002peb.2_Missense_Mutation_p.S125G	NM_001135113	NP_001128585	Q6UWQ7	IGFL2_HUMAN	IGF-like family member 2 isoform b	114						extracellular region	protein binding				0		Ovarian(192;0.0908)|all_neural(266;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(486;0.031)|Epithelial(262;0.247)		TAAATGTGAAAGGTAGGGACC	0.532													14	24					0	0	1	0	0
PNMAL1	55228	broad.mit.edu	37	19	46973885	46973885	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:46973885G>A	uc002peq.3	-	2	714	c.408C>T	c.(406-408)TCC>TCT	p.S136S	PNMAL1_uc002per.3_Silent_p.S136S	NM_018215	NP_060685	Q86V59	PNML1_HUMAN	PNMA-like 1 isoform a	136											0		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		gctggttctgggacagggtgg	0.159													34	60					0	0	1	0	0
EHD2	30846	broad.mit.edu	37	19	48239706	48239706	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:48239706C>T	uc002phj.3	+	5	1246	c.996C>T	c.(994-996)ATC>ATT	p.I332I	EHD2_uc010xyu.1_Silent_p.I196I|EHD2_uc010xyv.1_Silent_p.I15I	NM_014601	NP_055416	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	332					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			ovary(1)|skin(1)	2		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		AGCAGCTGATCCTCAAACTGC	0.488													31	66					0	0	1	0	0
SYNGR4	23546	broad.mit.edu	37	19	48879538	48879538	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:48879538C>T	uc002piz.2	+	5	913	c.668C>T	c.(667-669)CCA>CTA	p.P223L		NM_012451	NP_036583	O95473	SNG4_HUMAN	synaptogyrin 4	223						integral to membrane					0		all_epithelial(76;5.08e-07)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|Prostate(7;0.0143)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.00017)|Epithelial(262;0.0138)|GBM - Glioblastoma multiforme(486;0.0146)		CTGACCGCTCCAAAGTCCCCC	0.537													21	41					0	0	1	0	0
PRR12	57479	broad.mit.edu	37	19	50103127	50103127	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:50103127C>T	uc002poo.3	+	5	4277	c.4277C>T	c.(4276-4278)CCC>CTC	p.P1426L		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	605	Pro-rich.						DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CCCTTGGCCCCCGCGGCTGCA	0.667													19	38					0	0	1	0	0
SIGLEC11	114132	broad.mit.edu	37	19	50464043	50464043	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:50464043C>T	uc010ybh.1	-	2	317	c.226G>A	c.(226-228)GGA>AGA	p.G76R	SIGLEC11_uc010ybi.1_Missense_Mutation_p.G76R	NM_052884	NP_443116	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11 isoform 1	76	Ig-like V-type.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|central_nervous_system(2)|pancreas(1)	6		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		CTGGTCCGTCCTTTGAACCAG	0.607													20	43					0	0	1	0	0
NAPSA	9476	broad.mit.edu	37	19	50865036	50865036	+	Silent	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:50865036A>G	uc002prx.2	-	4	405	c.352T>C	c.(352-354)TTA>CTA	p.L118L	NR1H2_uc002prv.3_Intron	NM_004851	NP_004842	O96009	NAPSA_HUMAN	napsin A preproprotein	118					proteolysis	extracellular region	aspartic-type endopeptidase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0183)		CGGTGGTGTAACCCTAGGTTA	0.512													9	136					0	0	1	0	0
SIGLEC7	27036	broad.mit.edu	37	19	51647696	51647696	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:51647696G>A	uc002pvv.1	+	2	536	c.467G>A	c.(466-468)GGT>GAT	p.G156D	SIGLEC7_uc002pvw.1_Intron|SIGLEC7_uc010eoq.1_Intron|SIGLEC7_uc010eor.1_Intron	NM_014385	NP_055200	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7 isoform 1	156	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion	integral to plasma membrane	receptor activity|sugar binding			large_intestine(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		CTTATCCCCGGTACCCTGGAG	0.612													96	128					0	0	1	0	0
SIGLEC7	27036	broad.mit.edu	37	19	51647925	51647925	+	Silent	SNP	C	T	T	rs117714252	by1000genomes	TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:51647925C>T	uc002pvv.1	+	2	765	c.696C>T	c.(694-696)ATC>ATT	p.I232I	SIGLEC7_uc002pvw.1_Intron|SIGLEC7_uc010eoq.1_Intron|SIGLEC7_uc010eor.1_Intron	NM_014385	NP_055200	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7 isoform 1	232	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion	integral to plasma membrane	receptor activity|sugar binding			large_intestine(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		ACAGGACCATCCAACTCAATG	0.652													26	49					0	0	1	0	0
C19orf75	284369	broad.mit.edu	37	19	51769074	51769074	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:51769074C>T	uc002pwb.1	+	4	729	c.348C>T	c.(346-348)ATC>ATT	p.I116I	C19orf75_uc010eov.1_RNA|C19orf75_uc010ycw.1_Silent_p.I22I	NM_173635	NP_775906	Q8N7X8	CS075_HUMAN	hypothetical protein LOC284369	116						integral to membrane				ovary(1)|pancreas(1)	2						AAGGGCTGATCCAGGGTGCTA	0.498													157	204					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52033937	52033937	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:52033937G>A	uc002pwy.2	-	3	866	c.704C>T	c.(703-705)TCC>TTC	p.S235F	SIGLEC6_uc002pwz.2_Missense_Mutation_p.S235F|SIGLEC6_uc002pxa.2_Missense_Mutation_p.S235F|SIGLEC6_uc010ydb.1_Missense_Mutation_p.S188F|SIGLEC6_uc010ydc.1_Missense_Mutation_p.S224F|SIGLEC6_uc010eoz.1_Missense_Mutation_p.S213F|SIGLEC6_uc010epb.1_Missense_Mutation_p.S188F|SIGLEC6_uc010epa.1_Missense_Mutation_p.S224F	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	235	Extracellular (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		GCACTCACAGGAGACATTGAG	0.632													51	79					0	0	1	0	0
SIGLEC14	100049587	broad.mit.edu	37	19	52149516	52149516	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:52149516C>T	uc002pxf.3	-	2	535	c.415G>A	c.(415-417)GTG>ATG	p.V139M		NM_001098612	NP_001092082	Q08ET2	SIG14_HUMAN	sialic acid binding Ig-like lectin 14 precursor	139	Extracellular (Potential).				cell adhesion	integral to membrane|plasma membrane	protein binding|sugar binding			ovary(1)	1		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000965)|OV - Ovarian serous cystadenocarcinoma(262;0.0195)		ATACCTGTCACCTCCAAGTTC	0.557													42	66					0	0	1	0	0
ZNF649	65251	broad.mit.edu	37	19	52394736	52394736	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:52394736T>C	uc002pxy.2	-	5	921	c.653A>G	c.(652-654)AAG>AGG	p.K218R	ZNF577_uc010ydf.1_5'Flank	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	218	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		GAGCCTGTACTTCTTGTAGAA	0.483													6	78					0	0	1	0	0
ZNF649	65251	broad.mit.edu	37	19	52394769	52394769	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:52394769A>C	uc002pxy.2	-	5	888	c.620T>G	c.(619-621)GTG>GGG	p.V207G	ZNF577_uc010ydf.1_5'Flank	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	207	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		CAAGCTACACACGTGGGGTTT	0.488													4	58					0	0	1	0	0
ZNF615	284370	broad.mit.edu	37	19	52497604	52497604	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:52497604G>A	uc002pye.1	-	6	1017	c.725C>T	c.(724-726)TCC>TTC	p.S242F	ZNF615_uc002pyf.1_Missense_Mutation_p.S253F|ZNF615_uc002pyg.1_Missense_Mutation_p.S134F|ZNF615_uc002pyh.1_Missense_Mutation_p.S253F|ZNF615_uc010epi.1_Missense_Mutation_p.S249F|ZNF615_uc010ydg.1_Missense_Mutation_p.S247F	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	242	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		GGATTTTCTGGAGAAAGCTTT	0.408													48	63					0	0	1	0	0
ZNF616	90317	broad.mit.edu	37	19	52619656	52619656	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:52619656G>A	uc002pym.2	-	4	1044	c.761C>T	c.(760-762)TCA>TTA	p.S254L	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	254	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		TACAAAATATGAATTTTTTCT	0.398													22	29					0	0	1	0	0
ZNF160	90338	broad.mit.edu	37	19	53573081	53573081	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:53573081G>A	uc010eqk.2	-	7	1122	c.706C>T	c.(706-708)CAT>TAT	p.H236Y	ZNF160_uc002qaq.3_Missense_Mutation_p.H236Y|ZNF160_uc002qar.3_Missense_Mutation_p.H236Y	NM_001102603	NP_001096073	Q9HCG1	ZN160_HUMAN	zinc finger protein 160	236					hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(134;0.02)		TTAAGTTCATGATATTTTTTA	0.368													39	64					0	0	1	0	0
ZNF415	55786	broad.mit.edu	37	19	53612696	53612696	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:53612696G>A	uc002qax.2	-	7	1095	c.746C>T	c.(745-747)TCA>TTA	p.S249L	ZNF415_uc002qat.2_Missense_Mutation_p.S213L|ZNF415_uc002qaw.2_Missense_Mutation_p.S201L|ZNF415_uc010yds.1_Missense_Mutation_p.S201L|ZNF415_uc010ydt.1_Missense_Mutation_p.S201L|ZNF415_uc002qau.2_Missense_Mutation_p.S188L|ZNF415_uc002qav.2_Missense_Mutation_p.S213L|ZNF415_uc002qba.2_5'UTR|ZNF415_uc002qay.2_Missense_Mutation_p.S188L|ZNF415_uc002qaz.2_Missense_Mutation_p.S249L	NR_028343		Q09FC8	ZN415_HUMAN	RecName: Full=Zinc finger protein 415;	249					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.0191)		TGTGAGTAATGAAGAACAGAT	0.383													30	41					0	0	1	0	0
VN1R2	317701	broad.mit.edu	37	19	53762535	53762535	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:53762535C>T	uc002qbi.2	+	1	991	c.907C>T	c.(907-909)CTC>TTC	p.L303F		NM_173856	NP_776255	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	303	Cytoplasmic (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0				GBM - Glioblastoma multiforme(134;0.00301)		TAGGAACAATCTCTACCCCAA	0.493													57	77					0	0	1	0	0
ZNF765	91661	broad.mit.edu	37	19	53911860	53911860	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:53911860G>A	uc010ydx.1	+	6	1379	c.1052G>A	c.(1051-1053)GGA>GAA	p.G351E	ZNF765_uc002qbm.2_Missense_Mutation_p.G351E|ZNF765_uc002qbn.2_Intron	NM_001040185	NP_001035275	Q7L2R6	ZN765_HUMAN	zinc finger protein 765	351					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00379)		CTTCATACTGGAGAGAAACCT	0.423													4	154					0	0	1	0	0
CACNG8	59283	broad.mit.edu	37	19	54485595	54485595	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:54485595C>T	uc002qcs.1	+	4	873	c.767C>T	c.(766-768)CCC>CTC	p.P256L	MIR935_hsa-mir-935|MI0005757_RNA	NM_031895	NP_114101	Q8WXS5	CCG8_HUMAN	voltage-dependent calcium channel gamma-8	257	Gly-rich.				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		GGGAGCGGCCCCTCGGCCATC	0.627													3	1					0	0	1	0	0
LENG8	114823	broad.mit.edu	37	19	54966554	54966555	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:54966554_54966555CC>TT	uc002qfv.1	+	7	866_867	c.722_723CC>TT	c.(721-723)GCC>GTT	p.A241V	LENG8_uc002qfw.2_Missense_Mutation_p.A278V			Q96PV6	LENG8_HUMAN	RecName: Full=Leukocyte receptor cluster member 8;	241							protein binding			central_nervous_system(1)|pancreas(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		GGGTCCTCTGCCCGGGGGAACC	0.624													12	56					0	0	1	0	0
EPS8L1	54869	broad.mit.edu	37	19	55597332	55597332	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:55597332C>T	uc002qis.3	+	15	1613	c.1509C>T	c.(1507-1509)GAC>GAT	p.D503D	EPS8L1_uc010ess.1_Silent_p.D517D|EPS8L1_uc010yfr.1_Silent_p.D439D|EPS8L1_uc010esu.1_RNA|EPS8L1_uc002qiu.2_Silent_p.D376D|EPS8L1_uc002qiv.2_Silent_p.D181D|EPS8L1_uc002qiw.2_Silent_p.D282D	NM_133180	NP_573441	Q8TE68	ES8L1_HUMAN	epidermal growth factor receptor pathway	503	SH3.					cytoplasm					0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		AGCAGCGGGACGTACTGGAGG	0.577													12	21					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56244627	56244627	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:56244627C>T	uc002qly.2	-	2	598	c.570G>A	c.(568-570)ATG>ATA	p.M190I		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	190	NACHT.					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		CGATACCGTTCATTTCACAGA	0.453													5	17					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56321526	56321526	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:56321526G>A	uc010ygf.1	-	5	1161	c.450C>T	c.(448-450)TTC>TTT	p.F150F	NLRP11_uc002qlz.2_Silent_p.F51F|NLRP11_uc002qmb.2_Silent_p.F51F|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	150	NACHT.						ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CTCCCATCAGGAACACATTGA	0.393													5	32					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56487552	56487552	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:56487552T>G	uc002qmh.2	+	8	2830	c.2759T>G	c.(2758-2760)CTC>CGC	p.L920R	NLRP8_uc010etg.2_Missense_Mutation_p.L901R	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	920						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		ATCTCTGCGCTCTGTAAAAAT	0.373													29	33					0	0	1	0	0
ZNF444	55311	broad.mit.edu	37	19	56671150	56671150	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:56671150C>T	uc002qmm.2	+	5	931	c.564C>T	c.(562-564)TCC>TCT	p.S188S	ZNF444_uc002qmn.1_Silent_p.S187S	NM_018337	NP_060807	Q8N0Y2	ZN444_HUMAN	zinc finger protein 444	188	C2H2-type 1.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;3.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0531)		GCAAAACGTCCCTGAAACCAG	0.716													8	8					0	0	1	0	0
ZNF667	63934	broad.mit.edu	37	19	56953163	56953164	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:56953163_56953164GG>AA	uc002qnd.2	-	5	1362_1363	c.1200_1201CC>TT	c.(1198-1203)TCCCTT>TCTTTT	p.L401F	ZNF667_uc010etl.2_Missense_Mutation_p.L183F|ZNF667_uc002qne.2_Missense_Mutation_p.L401F|ZNF667_uc010etm.2_Missense_Mutation_p.L344F	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	401	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		TGTTGAATAAGGGATGAATGCC	0.356													12	13					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57175742	57175742	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:57175742C>T	uc010ygo.1	-	2	891	c.891G>A	c.(889-891)GAG>GAA	p.E297E	ZNF835_uc010ygn.1_Silent_p.E275E	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						GGTAGGGCTTCTCCTCCGTGT	0.687													10	15					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57328876	57328876	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:57328876C>T	uc002qnu.2	-	7	1285	c.934G>A	c.(934-936)GGA>AGA	p.G312R	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.G283R|PEG3_uc002qnv.2_Missense_Mutation_p.G312R|PEG3_uc002qnw.2_Missense_Mutation_p.G188R|PEG3_uc002qnx.2_Missense_Mutation_p.G186R|PEG3_uc010etr.2_Missense_Mutation_p.G312R	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	312					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ATTATCACTCCGTGGGAAGAT	0.463													6	74					0	0	1	0	0
ZIM3	114026	broad.mit.edu	37	19	57648247	57648248	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:57648247_57648248GG>AA	uc002qnz.1	-	4	620_621	c.234_235CC>TT	c.(232-237)GGCCGT>GGTTGT	p.R79C		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	79	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CTACCTGCACGGCCACTTCCCA	0.525													15	47					0	0	1	0	0
ZNF134	7693	broad.mit.edu	37	19	58132598	58132598	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:58132598C>T	uc002qpn.2	+	3	1210	c.1111C>T	c.(1111-1113)CCT>TCT	p.P371S	ZNF134_uc002qpo.2_Missense_Mutation_p.P198S|ZNF211_uc010yhb.1_5'UTR	NM_003435	NP_003426	P52741	ZN134_HUMAN	zinc finger protein 134	371						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		TGGTGAAAGGCCTTTTGTGTG	0.453													15	29					0	0	1	0	0
SNTG2	54221	broad.mit.edu	37	2	1079275	1079275	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:1079275G>A	uc002qwq.2	+	2	272	c.144G>A	c.(142-144)ACG>ACA	p.T48T	SNTG2_uc002qwp.2_RNA|SNTG2_uc010ewi.2_Silent_p.T48T	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	48					central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		TGAAGCTGACGAAAGAGGTGC	0.468													46	9					0	0	1	0	0
GRHL1	29841	broad.mit.edu	37	2	10136028	10136028	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:10136028G>A	uc002raa.2	+	13	1692	c.1521G>A	c.(1519-1521)CCG>CCA	p.P507P	GRHL1_uc002rab.2_RNA|GRHL1_uc002rad.2_Silent_p.P318P|GRHL1_uc010yjb.1_Silent_p.P356P	NM_198182	NP_937825	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1	507					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		AAAGGGGGCCGTACGGCACAG	0.468													4	270					0	0	1	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17699085	17699085	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:17699085C>T	uc002rcl.1	-	1	622	c.598G>A	c.(598-600)GAA>AAA	p.E200K	RAD51AP2_uc010exn.1_Missense_Mutation_p.E191K	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	200										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GATTTAGTTTCCTTGTAAAAG	0.299													4	46					0	0	1	0	0
KIF3C	3797	broad.mit.edu	37	2	26203522	26203522	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:26203522G>A	uc002rgu.2	-	1	1922	c.1265C>T	c.(1264-1266)CCT>CTT	p.P422L	KIF3C_uc010eyj.1_RNA|KIF3C_uc010ykr.1_Missense_Mutation_p.P422L	NM_002254	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	422	Potential.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGGCCCTCAGGGTACCCAGG	0.662													82	13					0	0	1	0	0
ABHD1	84696	broad.mit.edu	37	2	27346828	27346828	+	Silent	SNP	C	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:27346828C>A	uc002rit.2	+	1	172	c.12C>A	c.(10-12)TCC>TCA	p.S4S	ABHD1_uc002riu.2_RNA|ABHD1_uc002riv.2_RNA|ABHD1_uc002riw.2_Silent_p.S4S	NM_032604	NP_115993	Q96SE0	ABHD1_HUMAN	abhydrolase domain-containing protein 1	4						integral to membrane	carboxylesterase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCTGAGCTCCTTCCTGAGCC	0.637													6	69					5.18039e-06	5.22541e-06	1	1	0
GALNT14	79623	broad.mit.edu	37	2	31215761	31215761	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:31215761T>G	uc002rnr.2	-	2	861	c.242A>C	c.(241-243)CAG>CCG	p.Q81P	GALNT14_uc002rnq.2_Missense_Mutation_p.Q61P|GALNT14_uc002rns.2_Intron|GALNT14_uc010ymr.1_Missense_Mutation_p.Q46P|GALNT14_uc010ezo.1_Missense_Mutation_p.Q81P|GALNT14_uc010ezp.1_Missense_Mutation_p.Q52P	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	81	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					ACTCTCCCGCTGGTTGAAAGC	0.567													109	27					0	0	1	0	0
PRKD3	23683	broad.mit.edu	37	2	37543573	37543574	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:37543573_37543574GG>AA	uc002rqd.2	-	1	649_650	c.94_95CC>TT	c.(94-96)CCT>TTT	p.P32F	PRKD3_uc002rqf.1_Missense_Mutation_p.P32F	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	32					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				TCCCGTCTTAGGACTTGAACAC	0.495													7	61					0	0	1	0	0
MSH2	4436	broad.mit.edu	37	2	47656987	47656987	+	Nonsense_Mutation	SNP	C	T	T	rs63750302		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:47656987C>T	uc002rvy.1	+	7	1251	c.1183C>T	c.(1183-1185)CAA>TAA	p.Q395*	MSH2_uc010yoh.1_Nonsense_Mutation_p.Q329*|MSH2_uc002rvz.2_Nonsense_Mutation_p.Q395*|MSH2_uc010fbg.2_Nonsense_Mutation_p.Q205*	NM_000251	NP_000242	P43246	MSH2_HUMAN	mutS homolog 2	395					B cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|double-strand break repair|intra-S DNA damage checkpoint|isotype switching|maintenance of DNA repeat elements|male gonad development|meiotic gene conversion|meiotic mismatch repair|negative regulation of neuron apoptosis|negative regulation of reciprocal meiotic recombination|positive regulation of helicase activity|postreplication repair|response to UV-B|response to X-ray|somatic hypermutation of immunoglobulin genes	MutSalpha complex|MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|guanine/thymine mispair binding|loop DNA binding|protein C-terminus binding|protein homodimerization activity|protein kinase binding|Y-form DNA binding	p.?(1)		large_intestine(33)|haematopoietic_and_lymphoid_tissue(6)|endometrium(4)|ovary(3)|cervix(2)|central_nervous_system(2)|stomach(1)|small_intestine(1)|breast(1)|skin(1)|prostate(1)	55		all_hematologic(82;0.0359)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CAAGAAGTTTCAAAGACAAGC	0.378			D|Mis|N|F|S		colorectal|endometrial|ovarian	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				57	15					0	0	1	0	0
CCDC88A	55704	broad.mit.edu	37	2	55544848	55544848	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:55544848G>A	uc002ryv.2	-	20	4293	c.3451C>T	c.(3451-3453)CTC>TTC	p.L1151F	CCDC88A_uc010yoz.1_Missense_Mutation_p.L1152F|CCDC88A_uc010ypa.1_Missense_Mutation_p.L1151F|CCDC88A_uc002ryu.2_Missense_Mutation_p.L434F|CCDC88A_uc002rys.2_Missense_Mutation_p.L137F|CCDC88A_uc002ryw.2_Missense_Mutation_p.L435F|CCDC88A_uc010fby.1_Missense_Mutation_p.L31F	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	1152	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						GAATCATAGAGAGATTTTAGG	0.383													3	54					0	0	1	0	0
GKN2	200504	broad.mit.edu	37	2	69172503	69172503	+	Silent	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:69172503A>G	uc002sfa.2	-	6	661	c.552T>C	c.(550-552)GTT>GTC	p.V184V	GKN2_uc002sfb.3_3'UTR	NM_182536	NP_872342	Q86XP6	GKN2_HUMAN	trefoil factor interactions(z) 1 precursor	184						extracellular region					0						AATCATCCTAAACATGAATGT	0.393													146	29					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71825755	71825755	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:71825755C>T	uc002sie.2	+	33	3958	c.3582C>T	c.(3580-3582)ACC>ACT	p.T1194T	DYSF_uc010feg.2_Silent_p.T1225T|DYSF_uc010feh.2_Silent_p.T1180T|DYSF_uc002sig.3_Silent_p.T1180T|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Silent_p.T1194T|DYSF_uc010fef.2_Silent_p.T1211T|DYSF_uc010fei.2_Silent_p.T1211T|DYSF_uc010fek.2_Silent_p.T1212T|DYSF_uc010fej.2_Silent_p.T1181T|DYSF_uc010fel.2_Silent_p.T1181T|DYSF_uc010feo.2_Silent_p.T1226T|DYSF_uc010fem.2_Silent_p.T1195T|DYSF_uc010fen.2_Silent_p.T1212T|DYSF_uc002sif.2_Silent_p.T1195T|DYSF_uc010yqy.1_Silent_p.T75T	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1194	Cytoplasmic (Potential).|C2 4.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						TGAAGAACACCCTTAACCCCA	0.602													48	16					0	0	1	0	0
SFXN5	94097	broad.mit.edu	37	2	73215456	73215456	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:73215456G>A	uc002siq.2	-	10	687	c.556C>T	c.(556-558)CAG>TAG	p.Q186*	SFXN5_uc002sio.2_Nonsense_Mutation_p.Q78*|SFXN5_uc010yrc.1_Silent_p.F42F|SFXN5_uc002sip.2_Intron|SFXN5_uc010fet.2_Nonsense_Mutation_p.Q186*|SFXN5_uc010fes.2_5'UTR	NM_144579	NP_653180	Q8TD22	SFXN5_HUMAN	sideroflexin 5	186					iron ion homeostasis	integral to membrane	cation transmembrane transporter activity			ovary(1)	1						TTGGCTTTCTGAACCAGGACA	0.498													19	4					0	0	1	0	0
C2orf7	84279	broad.mit.edu	37	2	73455927	73455927	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:73455927C>T	uc002siy.2	-	4	510	c.442G>A	c.(442-444)GAC>AAC	p.D148N		NM_032319	NP_115695	Q9BSG0	PADC1_HUMAN	chromosome 2 open reading frame 7 precursor	148	PA.					extracellular region					0						CCTCACCCGTCTCGGCCGAGC	0.592													5	26					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74042462	74042462	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:74042462A>C	uc002sjr.1	+	3	1233	c.1112A>C	c.(1111-1113)AAG>ACG	p.K371T		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	371										ovary(2)	2						AACCTTTCAAAGCCTCTAGAT	0.443													27	7					0	0	1	0	0
STAMBP	10617	broad.mit.edu	37	2	74074526	74074526	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:74074526G>A	uc002sjs.2	+	5	438	c.388G>A	c.(388-390)GAG>AAG	p.E130K	STAMBP_uc002sjt.2_Missense_Mutation_p.E130K|STAMBP_uc002sju.2_Missense_Mutation_p.E130K|STAMBP_uc002sjv.2_Missense_Mutation_p.E130K	NM_201647	NP_964010	O95630	STABP_HUMAN	STAM binding protein	130	Glu-rich.				JAK-STAT cascade|positive regulation of cell proliferation	early endosome|membrane|nucleus	metal ion binding|metallopeptidase activity|protein binding			ovary(1)|lung(1)|breast(1)|pancreas(1)	4						GAAGGAAGCAGAGGAATTGGC	0.458													31	13					0	0	1	0	0
ACTG2	72	broad.mit.edu	37	2	74140759	74140759	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:74140759C>T	uc002sjw.2	+	6	721	c.599C>T	c.(598-600)TCC>TTC	p.S200F	ACTG2_uc010fey.2_Missense_Mutation_p.S200F|ACTG2_uc010yrn.1_Missense_Mutation_p.S157F	NM_001615	NP_001606	P63267	ACTH_HUMAN	actin, gamma 2 propeptide	200					muscle contraction	cytoskeleton|cytosol	ATP binding				0						AGAGGCTATTCCTTTGTGACC	0.512													56	18					0	0	1	0	0
FAM176A	84141	broad.mit.edu	37	2	75745252	75745252	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:75745252G>A	uc002sni.2	-	3	493	c.15C>T	c.(13-15)CTC>CTT	p.L5L	FAM176A_uc002snj.1_5'UTR|FAM176A_uc002snk.1_Silent_p.L5L	NM_001135032	NP_001128504	Q9H8M9	F176A_HUMAN	family with sequence similarity 176, member A	5	Necessary for the localization and biological activity.				apoptosis|autophagy	endoplasmic reticulum membrane|integral to membrane|lysosomal membrane|plasma membrane					0						GGCTGTGGCTGAGGGGCAGCC	0.567													5	49					0	0	1	0	0
Unknown	0	broad.mit.edu	37	2	89247062	89247063	+	RNA	DNP	AG	GA	GA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:89247062_89247063AG>GA	uc010ytr.1	-	101		c.7996_7997CT>TC			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		TGTCTCCTACAGATGCAGACAG	0.465													8	133					0	0	1	0	0
Unknown	0	broad.mit.edu	37	2	90008006	90008006	+	RNA	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:90008006C>T	uc010fhm.2	+	8		c.1179C>T								Parts of antibodies, mostly variable regions.																		TTCCTAAGCTCCTGATCTATG	0.522													58	13					0	0	1	0	0
SNRNP200	23020	broad.mit.edu	37	2	96949076	96949076	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:96949076G>A	uc002svu.2	-	34	4864	c.4778C>T	c.(4777-4779)ACC>ATC	p.T1593I	SNRNP200_uc002svt.2_Missense_Mutation_p.T203I|SNRNP200_uc010yuj.1_RNA|SNRNP200_uc002svv.1_Missense_Mutation_p.T120I	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	1593	Helicase C-terminal 2.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						ATCCTTCTCGGTGCAGTGCAA	0.567													48	13					0	0	1	0	0
FER1L5	90342	broad.mit.edu	37	2	97361546	97361546	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:97361546G>A	uc010fia.2	+	35	4043	c.4043G>A	c.(4042-4044)GGC>GAC	p.G1348D	FER1L5_uc002sws.3_Missense_Mutation_p.G66D|FER1L5_uc010fib.1_RNA|FER1L5_uc002swt.3_Missense_Mutation_p.G66D|FER1L5_uc010yus.1_Missense_Mutation_p.G65D	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	1348						integral to membrane				ovary(1)	1						TGGGCCTTCGGCCAGCAGACC	0.607													8	15					0	0	1	0	0
REV1	51455	broad.mit.edu	37	2	100022401	100022402	+	Silent	DNP	GG	AA	AA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:100022401_100022402GG>AA	uc002tad.2	-	17	2993_2994	c.2781_2782CC>TT	c.(2779-2784)AACCTG>AATTTG	p.927_928NL>NL	REV1_uc002tac.2_Silent_p.926_927NL>NL	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	927_928					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			ovary(2)	2						TCTATACTCAGGTTAAGTCTCG	0.401								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					59	17					0	0	1	0	0
C2orf29	55571	broad.mit.edu	37	2	101883186	101883186	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:101883186C>T	uc002taw.3	+	5	1165	c.1083C>T	c.(1081-1083)GGC>GGT	p.G361G		NM_017546	NP_060016	Q9UKZ1	CB029_HUMAN	hypothetical protein LOC55571	361					cell proliferation|nuclear-transcribed mRNA poly(A) tail shortening	cytosol				ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						ACCATATTGGCCTCACCCCAG	0.423													43	94					0	0	1	0	0
IL1R2	7850	broad.mit.edu	37	2	102641101	102641101	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:102641101G>A	uc002tbm.2	+	7	1087	c.858G>A	c.(856-858)CCG>CCA	p.P286P	IL1R2_uc002tbn.2_Silent_p.P286P|IL1R2_uc002tbo.1_Silent_p.P286P	NM_004633	NP_004624	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II precursor	286	Extracellular (Potential).|Ig-like C2-type 3.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			ovary(1)|breast(1)	2					Anakinra(DB00026)	GCGCCTACCCGGGAGGCCGCG	0.572													3	40					0	0	1	0	0
IL1RL1	9173	broad.mit.edu	37	2	102968044	102968044	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:102968044T>G	uc002tbu.1	+	11	1605	c.1334T>G	c.(1333-1335)ATT>AGT	p.I445S	IL18R1_uc002tbw.3_Intron	NM_016232	NP_057316	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1 isoform 1	445	TIR.|Cytoplasmic (Potential).				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			skin(2)|ovary(1)|central_nervous_system(1)	4						AGGCGGCACATTTTCATCCTG	0.458													6	47					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103274193	103274193	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:103274193G>T	uc002tca.2	+	2	602	c.460G>T	c.(460-462)GGC>TGC	p.G154C		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	154	Helical; Name=D/M4; (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						GCTGGATGCCGGCTATTTCAT	0.478													235	65					5.96336e-116	6.16701e-116	1	1	0
C2orf40	84417	broad.mit.edu	37	2	106694261	106694261	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:106694261G>A	uc010fjf.2	+	4	434	c.326G>A	c.(325-327)CGA>CAA	p.R109Q		NM_032411	NP_115787	Q9H1Z8	AUGN_HUMAN	esophageal cancer related gene 4 protein	109						extracellular region|transport vesicle					0						AACAGAGATCGAAATGGACAT	0.453													10	93					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108487725	108487725	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:108487725A>C	uc010ywk.1	+	20	3347	c.3265A>C	c.(3265-3267)AAA>CAA	p.K1089Q	RGPD4_uc002tdu.2_Missense_Mutation_p.K276Q|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1089	RanBD1 1.				intracellular transport		binding			skin(2)	2						AAAAATTCTCAAAAACGAGGT	0.403													17	159					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109352090	109352090	+	Missense_Mutation	SNP	C	T	T	rs140279690		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:109352090C>T	uc002tem.3	+	5	634	c.508C>T	c.(508-510)CGG>TGG	p.R170W		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	170					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						TGTGAACATCCGGCTAGTGGA	0.433													132	191					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116101408	116101408	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:116101408C>T	uc002tla.1	+	3	648	c.191C>T	c.(190-192)TCG>TTG	p.S64L	DPP10_uc002tlb.1_Missense_Mutation_p.S14L|DPP10_uc002tlc.1_Missense_Mutation_p.S60L|DPP10_uc002tle.2_Missense_Mutation_p.S68L|DPP10_uc002tlf.1_Missense_Mutation_p.S57L	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	64	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						CTCACAAATTCGTCAGAAACC	0.348													5	44					0	0	1	0	0
STEAP3	55240	broad.mit.edu	37	2	120005282	120005282	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:120005282G>A	uc002tlp.2	+	4	677	c.520G>A	c.(520-522)GCC>ACC	p.A174T	STEAP3_uc002tlq.2_Missense_Mutation_p.A184T|STEAP3_uc002tlr.2_Missense_Mutation_p.A174T|STEAP3_uc010fle.2_Missense_Mutation_p.A174T	NM_018234	NP_060704	Q658P3	STEA3_HUMAN	dudulin 2 isoform b	174	Cytoplasmic (Potential).				apoptosis|cell cycle|cellular iron ion homeostasis|protein secretion|transferrin transport|transmembrane transport	endosome membrane|integral to membrane|multivesicular body	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			central_nervous_system(2)|skin(1)	3						CCAGCCAGAAGCCAAGCGTGC	0.617													9	5					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128471452	128471452	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:128471452G>A	uc002tpg.1	-	18	3196	c.3013C>T	c.(3013-3015)CCT>TCT	p.P1005S		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	1005					postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		TCTGGGTGAGGGCCACGCCTA	0.652													14	234					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130832760	130832760	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:130832760C>T	uc010fmh.2	-	17	2685	c.2285G>A	c.(2284-2286)AGA>AAA	p.R762K		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	762	Actin-like.					cell cortex	ATP binding			skin(3)|ovary(2)	5						CAGGATGCCTCTTTTGCTCTG	0.577													99	26					0	0	1	0	0
LOC401010	401010	broad.mit.edu	37	2	132201901	132201901	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:132201901C>T	uc002tst.2	-	1	567	c.101G>A	c.(100-102)GGG>GAG	p.G34E		NR_002826				SubName: Full=cDNA FLJ12694 fis, clone NT2RP1000358, highly similar to Homo sapiens mRNA; cDNA DKFZp564C186 (from clone DKFZp564C186);												0						TTCCTGGTCCCCTTGGGTGGT	0.532													26	11					0	0	1	0	0
ACMSD	130013	broad.mit.edu	37	2	135630212	135630212	+	Splice_Site	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:135630212G>A	uc002ttz.2	+	8	916	c.849_splice	c.e8+1	p.K283_splice	ACMSD_uc002tua.2_Splice_Site_p.K225_splice|uc010zbe.1_Intron	NM_138326	NP_612199	Q8TDX5	ACMSD_HUMAN	aminocarboxymuconate semialdehyde decarboxylase						quinolinate metabolic process|tryptophan catabolic process	cytosol	aminocarboxymuconate-semialdehyde decarboxylase activity|metal ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.115)		CATAGGAAAGGTAAGCCCAGT	0.478													33	10					0	0	1	0	0
RAB3GAP1	22930	broad.mit.edu	37	2	135926253	135926253	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:135926253C>T	uc002tuj.2	+	24	2873	c.2848C>T	c.(2848-2850)CCC>TCC	p.P950S	RAB3GAP1_uc010fnf.2_Missense_Mutation_p.P957S|RAB3GAP1_uc010fng.2_Missense_Mutation_p.P775S|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	950						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		GCGCCCTGCTCCCTACTCCAA	0.537													29	75					0	0	1	0	0
SPOPL	339745	broad.mit.edu	37	2	139308107	139308107	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:139308107C>T	uc002tvh.2	+	3	533	c.133C>T	c.(133-135)CGA>TGA	p.R45*		NM_001001664	NP_001001664	Q6IQ16	SPOPL_HUMAN	speckle-type POZ protein-like	45	MATH.					nucleus				skin(2)|breast(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0296)		CAGTTTTTGTCGAGAGGAAAT	0.303													4	55					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141460054	141460054	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:141460054T>A	uc002tvj.1	-	38	7064	c.6092A>T	c.(6091-6093)AAG>ATG	p.K2031M		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2031	Extracellular (Potential).|LDL-receptor class B 21.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AAGGACAACCTTCTCTGAGCC	0.418										TSP Lung(27;0.18)			19	12					0	0	1	0	0
ARHGAP15	55843	broad.mit.edu	37	2	143973980	143973980	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:143973980A>C	uc002tvm.3	+	4	413	c.262A>C	c.(262-264)AAA>CAA	p.K88Q	ARHGAP15_uc010zbl.1_Missense_Mutation_p.K88Q	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	88	PH.				regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		TTATCTGCAAAAAGCTAAAAT	0.313													12	33					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152410454	152410454	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:152410454G>T	uc010fnx.2	-	98	14602	c.14411C>A	c.(14410-14412)TCC>TAC	p.S4804Y	NEB_uc002txr.2_Missense_Mutation_p.S1227Y	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	4804	Nebulin 131.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTTCTTCTGGGAATCCTTGGC	0.453													81	22					1.92787e-56	1.98633e-56	1	1	0
NEB	4703	broad.mit.edu	37	2	152529135	152529135	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:152529135G>A	uc010fnx.2	-	37	4238	c.4047C>T	c.(4045-4047)CTC>CTT	p.L1349L		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	1349	Nebulin 34.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GATCATCCTGGAGGCTTCTGA	0.438													71	12					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160661572	160661572	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:160661572G>A	uc002ubc.3	-	35	5221	c.5152C>T	c.(5152-5154)CCT>TCT	p.P1718S	LY75_uc002ubb.3_Intron|LY75_uc010fos.2_Intron	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	1718	Cytoplasmic (Potential).				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		TGGAAAGAAGGAAGCATAATC	0.388													5	41					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167149779	167149779	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:167149779G>A	uc010fpl.2	-	9	1410	c.1069C>T	c.(1069-1071)CTA>TTA	p.L357L	uc002udp.2_Intron|SCN9A_uc002udr.1_Silent_p.L228L|SCN9A_uc002uds.1_Silent_p.L228L|SCN9A_uc002udt.1_Silent_p.L228L	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	357	I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TGGGTCATTAGCCTAAACAAG	0.433													4	1					0	0	1	0	0
PHOSPHO2	493911	broad.mit.edu	37	2	170557707	170557707	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:170557707C>T	uc002ufg.2	+	4	614	c.226C>T	c.(226-228)CCA>TCA	p.P76S	KLHL23_uc002ufh.1_Intron	NM_001008489	NP_001008489	Q8TCD6	PHOP2_HUMAN	phosphatase, orphan 2	76							metal ion binding|pyridoxal phosphatase activity			skin(1)	1						GCCTTTCACTCCAGGGATGGT	0.348													6	44					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179412758	179412758	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:179412758C>T	uc010zfg.1	-	288	86115	c.85891G>A	c.(85891-85893)GAA>AAA	p.E28631K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E22326K|TTN_uc010zfi.1_Missense_Mutation_p.E22259K|TTN_uc010zfj.1_Missense_Mutation_p.E22134K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29558							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGAAGGCTTCTCTGGGTTCA	0.453													18	0					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179412796	179412796	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:179412796A>G	uc010zfg.1	-	288	86077	c.85853T>C	c.(85852-85854)GTG>GCG	p.V28618A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V22313A|TTN_uc010zfi.1_Missense_Mutation_p.V22246A|TTN_uc010zfj.1_Missense_Mutation_p.V22121A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29545							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTGGCCTTCACACGGAATTC	0.463													6	40					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179425152	179425152	+	Silent	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:179425152A>G	uc010zfg.1	-	275	78227	c.78003T>C	c.(78001-78003)CTT>CTC	p.L26001L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.L19696L|TTN_uc010zfi.1_Silent_p.L19629L|TTN_uc010zfj.1_Silent_p.L19504L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26928							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGACCAGCAAAGTGTCATAG	0.413													17	2					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179498632	179498632	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:179498632C>T	uc010zfg.1	-	180	35114	c.34890G>A	c.(34888-34890)TTG>TTA	p.L11630L	TTN_uc010zfh.1_Silent_p.L5325L|TTN_uc010zfi.1_Silent_p.L5258L|TTN_uc010zfj.1_Silent_p.L5133L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12557							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTCATTTCCAATTTGTGAG	0.398													3	64					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179598410	179598410	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:179598410C>T	uc010zfg.1	-	50	12198	c.11974G>A	c.(11974-11976)GGC>AGC	p.G3992S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.G653S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4919							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGTATTTGCCTCCAAAACTA	0.393													29	9					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179638758	179638758	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:179638758G>A	uc010zfg.1	-	31	7361	c.7137C>T	c.(7135-7137)GTC>GTT	p.V2379V	TTN_uc010zfh.1_Silent_p.V2333V|TTN_uc010zfi.1_Silent_p.V2333V|TTN_uc010zfj.1_Silent_p.V2333V|TTN_uc002unb.2_Silent_p.V2379V|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2379							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCCAAGGAGACTTTAACTT	0.468													54	7					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179650595	179650595	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:179650595C>T	uc010zfg.1	-	14	2574	c.2350G>A	c.(2350-2352)GGA>AGA	p.G784R	TTN_uc010zfh.1_Missense_Mutation_p.G738R|TTN_uc010zfi.1_Missense_Mutation_p.G738R|TTN_uc010zfj.1_Missense_Mutation_p.G738R|TTN_uc002unb.2_Missense_Mutation_p.G784R|TTN_uc010frg.1_Missense_Mutation_p.G366R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	784							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGTGCATTCCCTTTTGATCA	0.463													17	27					0	0	1	0	0
ZNF385B	151126	broad.mit.edu	37	2	180383312	180383312	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:180383312G>A	uc002unn.3	-	5	1054	c.450C>T	c.(448-450)CCC>CCT	p.P150P	ZNF385B_uc002unj.2_Silent_p.P48P|ZNF385B_uc002unk.2_RNA|ZNF385B_uc002unl.2_Silent_p.P47P|ZNF385B_uc002unm.2_Silent_p.P74P	NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	150						nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			TCTTCTTTGGGGGAATGGATA	0.348													53	14					0	0	1	0	0
CERKL	375298	broad.mit.edu	37	2	182521566	182521566	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:182521566C>T	uc002unx.2	-	1	269	c.168G>A	c.(166-168)AGG>AGA	p.R56R	CERKL_uc002uny.2_Silent_p.R56R|CERKL_uc010zfm.1_Silent_p.R56R|CERKL_uc002unz.2_5'UTR|CERKL_uc002uoa.2_Silent_p.R56R|CERKL_uc002uob.2_5'UTR|CERKL_uc002uoc.2_Silent_p.R56R|CERKL_uc010frk.2_RNA|CERKL_uc002uod.1_Intron|CERKL_uc002uoe.2_Silent_p.R56R	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	56					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CACAACTGTCCCTCCCGATCT	0.711													6	71					0	0	1	0	0
MSTN	2660	broad.mit.edu	37	2	190922019	190922019	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:190922019G>A	uc002urp.2	-	3	1226	c.1093C>T	c.(1093-1095)CCA>TCA	p.P365S		NM_005259	NP_005250	O14793	GDF8_HUMAN	myostatin precursor	365					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			ACCATCGCTGGAATTTTCCCA	0.403													18	3					0	0	1	0	0
SLC39A10	57181	broad.mit.edu	37	2	196599658	196599658	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:196599658C>T	uc002utg.3	+	10	2603	c.2389C>T	c.(2389-2391)CCT>TCT	p.P797S	SLC39A10_uc002uth.3_Missense_Mutation_p.P797S|SLC39A10_uc010zgp.1_Missense_Mutation_p.P347S	NM_001127257	NP_001120729	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter),	797					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.221)			TGGCTTTTGTCCTGTGGGGCA	0.368													4	92					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196673492	196673492	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:196673492G>A	uc002utj.3	-	53	10098	c.9997C>T	c.(9997-9999)CGA>TGA	p.R3333*		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3333					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TCATCTAATCGACATATTTCA	0.408													56	17					0	0	1	0	0
HSPD1	3329	broad.mit.edu	37	2	198353814	198353814	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:198353814T>C	uc002uui.2	-	9	1264	c.1127A>G	c.(1126-1128)GAG>GGG	p.E376G	HSPD1_uc002uuj.2_Missense_Mutation_p.E374G|HSPD1_uc010zgx.1_Missense_Mutation_p.E367G|HSPD1_uc010fsm.2_Missense_Mutation_p.E187G|HSPD1_uc002uuk.2_Missense_Mutation_p.E376G	NM_002156	NP_002147	P10809	CH60_HUMAN	chaperonin	376					'de novo' protein folding|activation of caspase activity|B cell cytokine production|B cell proliferation|chaperone-mediated protein complex assembly|interspecies interaction between organisms|isotype switching to IgG isotypes|MyD88-dependent toll-like receptor signaling pathway|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of macrophage activation|positive regulation of T cell activation|positive regulation of T cell mediated immune response to tumor cell|protein maturation|protein refolding|protein stabilization|response to unfolded protein|T cell activation	cell surface|coated pit|coated vesicle|cytosol|early endosome|extracellular space|lipopolysaccharide receptor complex|mitochondrial inner membrane|mitochondrial matrix|stored secretory granule	ATP binding|ATPase activity|cell surface binding|chaperone binding|DNA replication origin binding|lipopolysaccharide binding|p53 binding|single-stranded DNA binding				0			Epithelial(96;0.225)			ATCTAACTGCTCAATGATTTC	0.388													5	52					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215882781	215882781	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:215882781C>T	uc002vew.2	-	14	1953	c.1733G>A	c.(1732-1734)AGG>AAG	p.R578K	ABCA12_uc002vev.2_Missense_Mutation_p.R260K|ABCA12_uc010zjn.1_5'UTR	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	578					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		gtCAATAGTCCTGTTGGACAT	0.184													35	10					0	0	1	0	0
SMARCAL1	50485	broad.mit.edu	37	2	217297462	217297462	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:217297462C>T	uc002vgc.3	+	8	1686	c.1356C>T	c.(1354-1356)GGC>GGT	p.G452G	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Silent_p.G452G|SMARCAL1_uc010fvg.2_Silent_p.G452G	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	452	Helicase ATP-binding.				chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		CCAAAGGAGGCCGCCTGCTGC	0.602									Schimke_Immuno-Osseous_Dysplasia				41	21					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219875643	219875643	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:219875643C>T	uc002vjl.1	-	25	4117	c.4033G>A	c.(4033-4035)GAA>AAA	p.E1345K		NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	1345						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAATTTTTTTCCTGAACCTGT	0.507													23	9					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219903674	219903674	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:219903674G>A	uc002vjl.1	-	3	181	c.97C>T	c.(97-99)CTC>TTC	p.L33F	CCDC108_uc010zkp.1_Intron|CCDC108_uc010zkq.1_Intron|CCDC108_uc002vjn.2_Intron	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	33						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTCTTAGGAGAAGAGGAATA	0.453													7	79					0	0	1	0	0
KIAA1486	57624	broad.mit.edu	37	2	226446942	226446942	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:226446942A>C	uc002voe.2	+	4	984	c.809A>C	c.(808-810)GAA>GCA	p.E270A	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Missense_Mutation_p.E40A	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	270										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		GTCTACGAGGAAATGAAGTAC	0.552													79	13					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227906890	227906890	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:227906890C>T	uc010zlt.1	-	37	4133	c.3479G>A	c.(3478-3480)GGG>GAG	p.G1160E		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	1160	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		ACCTGGTATCCCTGGATCCCC	0.542													5	57					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227953470	227953470	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:227953470G>A	uc010zlt.1	-	22	2176	c.1522C>T	c.(1522-1524)CCT>TCT	p.P508S		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	508	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TGCCTCCCAGGAAGTCCTGGA	0.587													31	11					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230231825	230231825	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:230231825C>T	uc002vpv.2	-	12	2013	c.1866G>A	c.(1864-1866)TGG>TGA	p.W622*		NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	622	Extracellular (Potential).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		GCCCGGACTTCCATTGGAGGT	0.483													30	10					0	0	1	0	0
SH3BP4	23677	broad.mit.edu	37	2	235950337	235950337	+	Silent	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:235950337T>C	uc002vvp.2	+	4	1317	c.924T>C	c.(922-924)GGT>GGC	p.G308G	SH3BP4_uc010fym.2_Silent_p.G308G|SH3BP4_uc002vvq.2_Silent_p.G308G	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	308					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		AAAGCCCTGGTTGGGGCCAGA	0.592													8	48					0	0	1	0	0
CXCR7	57007	broad.mit.edu	37	2	237490146	237490146	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:237490146C>T	uc010fyq.2	+	3	1268	c.1038C>T	c.(1036-1038)GCC>GCT	p.A346A	CXCR7_uc002vwd.2_Silent_p.A346A	NM_020311	NP_064707	P25106	CXCR7_HUMAN	chemokine orphan receptor 1	346	Cytoplasmic (Potential).				interspecies interaction between organisms	integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3		Breast(86;0.000182)|Renal(207;0.00339)|all_hematologic(139;0.0048)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|all_lung(227;0.147)|all_neural(83;0.223)		Epithelial(121;8.35e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.09e-11)|Kidney(56;1.11e-07)|KIRC - Kidney renal clear cell carcinoma(57;3.03e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000176)|Lung(119;0.00468)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.118)		TCATCGATGCCTCCAGAGTCT	0.517													35	11					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238296529	238296530	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:238296529_238296530CC>TT	uc002vwl.2	-	4	1292_1293	c.1007_1008GG>AA	c.(1006-1008)CGG>CAA	p.R336Q	COL6A3_uc002vwo.2_Missense_Mutation_p.R130Q|COL6A3_uc010znj.1_Intron|COL6A3_uc002vwq.2_Missense_Mutation_p.R130Q|COL6A3_uc002vwr.2_Intron|COL6A3_uc010znk.1_Missense_Mutation_p.R336Q	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	336	VWFA 2.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TGCCCCCTGCCCGGGTGAAGTG	0.624													4	25					0	0	1	0	0
PRLH	51052	broad.mit.edu	37	2	238475737	238475737	+	Silent	SNP	G	A	A	rs145946342	byFrequency	TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:238475737G>A	uc010znl.1	+	2	183	c.183G>A	c.(181-183)GGG>GGA	p.G61G		NM_015893	NP_056977	P81277	PRRP_HUMAN	prolactin releasing hormone precursor	61						extracellular region					0		Lung NSC(271;0.142)|all_lung(227;0.175)		Epithelial(121;8.28e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.03e-10)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.19e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000329)|Lung(119;0.0106)|LUSC - Lung squamous cell carcinoma(224;0.0249)		CAACCCTGGGGGACGTCCCCA	0.647													18	37					0	0	1	0	0
SCLY	51540	broad.mit.edu	37	2	239003128	239003128	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:239003128C>T	uc010fyv.2	+	10	1137	c.1073C>T	c.(1072-1074)ACC>ATC	p.T358I	SCLY_uc002vxm.3_Missense_Mutation_p.T325I|SCLY_uc002vxn.2_3'UTR|SCLY_uc010znq.1_Missense_Mutation_p.T152I|SCLY_uc010znr.1_Missense_Mutation_p.T264I|SCLY_uc002vxp.3_5'Flank	NM_016510	NP_057594	Q96I15	SCLY_HUMAN	selenocysteine lyase	358					cellular amino acid metabolic process	cytosol	pyridoxal phosphate binding|selenocysteine lyase activity|transferase activity			ovary(2)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;1.37e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.6e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.25e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000128)|Lung(119;0.0118)|LUSC - Lung squamous cell carcinoma(224;0.0285)		CTTCCCAATACCTGTAACTTT	0.522													11	95					0	0	1	0	0
ANKMY1	51281	broad.mit.edu	37	2	241421665	241421665	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:241421665G>A	uc002vyz.1	-	15	2782	c.2553C>T	c.(2551-2553)CCC>CCT	p.P851P	ANKMY1_uc002vza.1_Silent_p.P627P|ANKMY1_uc010fzd.1_Silent_p.P940P|ANKMY1_uc002vzb.1_Silent_p.P612P|ANKMY1_uc002vzc.1_Silent_p.P630P|ANKMY1_uc002vzd.1_Silent_p.P674P	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	851							zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		TCCTGTGGCTGGGGATCAGCT	0.632													39	12					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241700163	241700163	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:241700163G>A	uc002vzy.2	-	24	2482	c.2336C>T	c.(2335-2337)CCC>CTC	p.P779L	KIF1A_uc010fzk.2_Missense_Mutation_p.P788L|KIF1A_uc002vzz.1_Missense_Mutation_p.P788L	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	779					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GCGGGGGAAGGGCCGCGTCTC	0.652													22	4					0	0	1	0	0
RSPO4	343637	broad.mit.edu	37	20	947858	947858	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:947858G>A	uc002wej.2	-	3	465	c.368C>T	c.(367-369)CCG>CTG	p.P123L	RSPO4_uc002wek.2_Missense_Mutation_p.P123L	NM_001029871	NP_001025042	Q2I0M5	RSPO4_HUMAN	R-spondin family, member 4 isoform 1 precursor	123	FU.				Wnt receptor signaling pathway	extracellular region	heparin binding				0						AGTGCCCGGCGGGCAGGTGGG	0.647													62	79					0	0	1	0	0
SIRPB2	284759	broad.mit.edu	37	20	1460519	1460519	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:1460519G>A	uc002wfg.2	-	2	505	c.277C>T	c.(277-279)CCT>TCT	p.P93S	SIRPB2_uc002wfh.3_Intron|SIRPB2_uc010zpr.1_Intron	NM_001122962	NP_001116434	Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2 isoform 1	93	Ig-like V-type 1.|Extracellular (Potential).					integral to membrane					0						ATTACCCCAGGGAAGGAGCCA	0.468													41	51					0	0	1	0	0
ZNF343	79175	broad.mit.edu	37	20	2464182	2464182	+	Silent	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:2464182A>G	uc002wge.1	-	6	1913	c.1425T>C	c.(1423-1425)AGT>AGC	p.S475S	ZNF343_uc010gao.1_Silent_p.S475S|ZNF343_uc002wgd.1_Silent_p.S385S	NM_024325	NP_077301	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	475	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						GTGATTTCCGACTAAAGCCTC	0.527													3	106					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2597726	2597726	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:2597726C>T	uc002wgf.1	+	16	1964	c.1949C>T	c.(1948-1950)TCC>TTC	p.S650F	TMC2_uc002wgg.1_Missense_Mutation_p.S634F	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	650	Cytoplasmic (Potential).					integral to membrane				ovary(3)	3						AGGATGGGCTCCTTCTATGCT	0.572													32	51					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3680096	3680096	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:3680096G>A	uc002wja.2	-	7	1539	c.1539C>T	c.(1537-1539)CTC>CTT	p.L513L	SIGLEC1_uc002wiz.3_Silent_p.L513L	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	513	Ig-like C2-type 5.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						GGCTGATGAGGAGACGGGCGG	0.627													20	13					0	0	1	0	0
RASSF2	9770	broad.mit.edu	37	20	4771127	4771127	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:4771127G>A	uc002wld.2	-	6	561	c.507C>T	c.(505-507)TTC>TTT	p.F169F	RASSF2_uc002wlc.2_RNA|RASSF2_uc002wle.2_RNA|RASSF2_uc002wlf.2_Silent_p.F169F	NM_170774	NP_739580	P50749	RASF2_HUMAN	Ras association domain family 2	169					cell cycle|signal transduction	nucleus	protein binding			ovary(3)|lung(2)|large_intestine(1)	6						CGTTGATGGAGAAGCGGTGGC	0.602													28	53					0	0	1	0	0
CHGB	1114	broad.mit.edu	37	20	5903571	5903571	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:5903571G>A	uc002wmg.2	+	4	1087	c.781G>A	c.(781-783)GAA>AAA	p.E261K	CHGB_uc010zqz.1_5'UTR	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	261						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						CCGAAGCCAGGAAGAATCTGA	0.597													13	8					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8698409	8698409	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:8698409G>T	uc002wnb.2	+	14	1430	c.1427G>T	c.(1426-1428)GGA>GTA	p.G476V	PLCB1_uc010zrb.1_Missense_Mutation_p.G375V|PLCB1_uc002wna.2_Missense_Mutation_p.G476V|PLCB1_uc002wnc.1_Missense_Mutation_p.G375V|PLCB1_uc002wnd.1_Missense_Mutation_p.G53V	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	476					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						TCATCAGAAGGAAGCGGCAAA	0.463													9	51					7.48243e-07	7.56388e-07	1	1	0
PLCB4	5332	broad.mit.edu	37	20	9400512	9400512	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:9400512G>A	uc002wnf.2	+	24	2210	c.2074G>A	c.(2074-2076)GAA>AAA	p.E692K	PLCB4_uc010gbw.1_Missense_Mutation_p.E692K|PLCB4_uc010gbx.2_Missense_Mutation_p.E704K|PLCB4_uc002wne.2_Missense_Mutation_p.E692K|PLCB4_uc002wnh.2_Missense_Mutation_p.E539K	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	692	C2.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						CCCCTTCTCTGAAACTCCTGT	0.438													95	152					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13098175	13098175	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:13098175C>T	uc002wod.1	+	8	1244	c.955C>T	c.(955-957)CTG>TTG	p.L319L		NM_018327	NP_060797	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base	319					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups				0					Pyridoxal Phosphate(DB00114)	CATCGTGCATCTGCCCCAGAT	0.502													55	151					0	0	1	0	0
PCSK2	5126	broad.mit.edu	37	20	17434589	17434589	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:17434589C>T	uc002wpm.2	+	9	1408	c.1088C>T	c.(1087-1089)CCC>CTC	p.P363L	PCSK2_uc002wpl.2_Missense_Mutation_p.P344L|PCSK2_uc010zrm.1_Missense_Mutation_p.P328L	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	363	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AAAAGGAACCCCGAGGCCGGT	0.602													30	29					0	0	1	0	0
DTD1	92675	broad.mit.edu	37	20	18608840	18608840	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:18608840C>T	uc002wrf.3	+	4	601	c.440C>T	c.(439-441)TCG>TTG	p.S147L		NM_080820	NP_543010	Q8TEA8	DTD1_HUMAN	D-tyrosyl-tRNA deacylase 1	147					D-amino acid catabolic process	cytoplasm	hydrolase activity, acting on ester bonds			ovary(2)	2						GAGCTGGAATCGCCAGCTCCC	0.537													37	54					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19662566	19662566	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:19662566G>A	uc002wrl.2	+	10	1029	c.832G>A	c.(832-834)GGA>AGA	p.G278R		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	278	Cytoplasmic (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1						CATGGTCAACGGATTGGCCAA	0.443													43	91					0	0	1	0	0
COX4I2	84701	broad.mit.edu	37	20	30227861	30227861	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:30227861G>A	uc002wwj.1	+	3	283	c.208G>A	c.(208-210)GGA>AGA	p.G70R	COX4I2_uc002wwi.2_Missense_Mutation_p.G70R	NM_032609	NP_115998	Q96KJ9	COX42_HUMAN	cytochrome c oxidase subunit IV isoform 2	70					cellular respiration		cytochrome-c oxidase activity			ovary(1)	1	all_cancers(5;7.12e-06)|Lung NSC(7;3.95e-06)|all_epithelial(3;4.36e-06)|all_lung(7;6.68e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;1.01e-05)|all cancers(5;9.46e-05)|OV - Ovarian serous cystadenocarcinoma(3;0.00121)|Colorectal(19;0.0055)|COAD - Colon adenocarcinoma(19;0.0264)			GAAGGAGAAGGGAAGCTGGAC	0.587													10	32					0	0	1	0	0
C20orf185	359710	broad.mit.edu	37	20	31643289	31643289	+	Silent	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:31643289A>G	uc002wym.1	+	1	60	c.60A>G	c.(58-60)CCA>CCG	p.P20P		NM_182658	NP_872599	P59826	LPLC3_HUMAN	antimicrobial peptide RYA3 precursor	20	Leu-rich.				innate immune response	cytoplasm|extracellular region	lipid binding|protein binding			ovary(4)	4						TGGCGACTCCATGCCAGGAGC	0.617													11	97					0	0	1	0	0
C20orf114	92747	broad.mit.edu	37	20	31890830	31890830	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:31890830G>A	uc002wyw.1	+	11	1251	c.1090G>A	c.(1090-1092)GAA>AAA	p.E364K	C20orf114_uc002wyx.1_RNA	NM_033197	NP_149974	Q8TDL5	LPLC1_HUMAN	LPLUNC1 protein precursor	364						extracellular space	lipid binding			central_nervous_system(2)|skin(2)	4						GATCGTGCTGGAAGTGTTTCC	0.537													49	143					0	0	1	0	0
ITCH	83737	broad.mit.edu	37	20	33067434	33067434	+	Splice_Site	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:33067434G>A	uc010geu.1	+	19	1974	c.1782_splice	c.e19-1	p.R594_splice	ITCH_uc002xak.2_Splice_Site_p.R553_splice|ITCH_uc010zuj.1_Splice_Site_p.R443_splice	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase						apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						TTTGATTTCAGAGAATGGTTC	0.378													4	26					0	0	1	0	0
PIGU	128869	broad.mit.edu	37	20	33233114	33233114	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:33233114G>A	uc002xas.2	-	3	420	c.220C>T	c.(220-222)CAT>TAT	p.H74Y	PIGU_uc010zul.1_Missense_Mutation_p.H74Y|PIGU_uc002xat.2_Intron|PIGU_uc010gev.1_Intron	NM_080476	NP_536724	Q9H490	PIGU_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	74	Helical; (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|regulation of JAK-STAT cascade	GPI-anchor transamidase complex|plasma membrane					0						ATTAGGAAATGAAAGAGGTAT	0.269													13	20					0	0	1	0	0
GSS	2937	broad.mit.edu	37	20	33529574	33529574	+	Missense_Mutation	SNP	G	A	A	rs113191242		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:33529574G>A	uc002xbg.2	-	6	630	c.550C>T	c.(550-552)CCC>TCC	p.P184S	GSS_uc010zun.1_Missense_Mutation_p.P56S|GSS_uc010zuo.1_Intron|GSS_uc010zup.1_Missense_Mutation_p.P115S|GSS_uc002xbh.2_RNA|GSS_uc010gez.1_Intron	NM_000178	NP_000169	P48637	GSHB_HUMAN	glutathione synthetase	184					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	CCCTTGCTGGGATTATTAGAG	0.498													41	50					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33584226	33584226	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:33584226G>A	uc002xbi.1	+	27	3239	c.3147G>A	c.(3145-3147)CAG>CAA	p.Q1049Q		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	1007	Potential.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			AGGCGTTGCAGGAGGCCCACC	0.657													23	20					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34091156	34091156	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:34091156C>T	uc002xcm.2	+	31	5630	c.4959C>T	c.(4957-4959)CTC>CTT	p.L1653L	CEP250_uc010zve.1_Silent_p.L1021L	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	1653	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			CTCAGGATCTCGAGAGGAGAG	0.567													79	92					0	0	1	0	0
NFS1	9054	broad.mit.edu	37	20	34263027	34263027	+	Silent	SNP	C	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:34263027C>A	uc002xdw.1	-	8	952	c.888G>T	c.(886-888)GTG>GTT	p.V296V	CPNE1_uc002xdn.1_5'Flank|CPNE1_uc002xdo.1_5'Flank|CPNE1_uc002xdp.1_5'Flank|NFS1_uc002xdt.1_Silent_p.V236V|NFS1_uc002xdu.1_Silent_p.V236V|NFS1_uc002xdv.1_Intron|NFS1_uc010zvk.1_Silent_p.V94V|NFS1_uc010zvl.1_Silent_p.V245V	NM_021100	NP_066923	Q9Y697	NFS1_HUMAN	NFS1 nitrogen fixation 1 precursor	296					cysteine metabolic process|iron incorporation into metallo-sulfur cluster|Mo-molybdopterin cofactor biosynthetic process|protein complex assembly|water-soluble vitamin metabolic process	cytosol|mitochondrial matrix|nucleus	cysteine desulfurase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)|skin(1)	2	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.0886)		L-Alanine(DB00160)|L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	AGGGTGTGGGCACTGTCCCAG	0.657													71	86					6.47592e-44	6.66737e-44	1	1	0
MANBAL	63905	broad.mit.edu	37	20	35929739	35929739	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:35929739G>C	uc002xgu.2	+	3	285	c.73G>C	c.(73-75)GGA>CGA	p.G25R	MANBAL_uc002xgv.2_Missense_Mutation_p.G25R|MANBAL_uc002xgw.2_RNA|MANBAL_uc010gfx.2_RNA|MANBAL_uc010gfy.2_RNA	NM_022077	NP_071360	Q9NQG1	MANBL_HUMAN	mannosidase, beta A, lysosomal-like	25	Helical; (Potential).					integral to membrane					0		Myeloproliferative disorder(115;0.00878)				GCTACGGTACGGACTCTTCCT	0.597													64	62					0	0	1	0	0
TGM2	7052	broad.mit.edu	37	20	36779354	36779354	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:36779354C>T	uc002xhr.2	-	4	639	c.539G>A	c.(538-540)TGG>TAG	p.W180*	TGM2_uc010zvx.1_Nonsense_Mutation_p.W99*|TGM2_uc010zvy.1_Nonsense_Mutation_p.W120*|TGM2_uc002xhs.1_Nonsense_Mutation_p.W156*|TGM2_uc002xht.2_Nonsense_Mutation_p.W180*|TGM2_uc002xhu.3_Nonsense_Mutation_p.W180*	NM_004613	NP_004604	P21980	TGM2_HUMAN	transglutaminase 2 isoform a	180					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(1)|lung(1)|ovary(1)	3		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	CCCAAAATTCCAAGGTATGTT	0.587													121	170					0	0	1	0	0
JPH2	57158	broad.mit.edu	37	20	42788431	42788431	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:42788431G>A	uc002xli.1	-	2	1869	c.996C>T	c.(994-996)CCC>CCT	p.P332P		NM_020433	NP_065166	Q9BR39	JPH2_HUMAN	junctophilin 2 isoform 1	332	MORN 8.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane					0		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GGTGGCCGTCGGGCAGCGTGG	0.662													37	48					0	0	1	0	0
RIMS4	140730	broad.mit.edu	37	20	43385563	43385563	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:43385563C>T	uc002xms.2	-	5	567	c.567G>A	c.(565-567)GAG>GAA	p.E189E	RIMS4_uc010ggu.2_Silent_p.E190E	NM_182970	NP_892015	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	189	C2.				exocytosis|neurotransmitter transport	cell junction|synapse				ovary(4)|central_nervous_system(1)	5		Myeloproliferative disorder(115;0.0122)				CCTGGGGACTCTCAGGAAACA	0.557													230	271					0	0	1	0	0
WFDC10B	280664	broad.mit.edu	37	20	44313599	44313599	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:44313599C>T	uc002xpb.2	-	4	323	c.92G>A	c.(91-93)AGA>AAA	p.R31K	WFDC10B_uc002xpc.2_Missense_Mutation_p.G47E	NM_172006	NP_742003	Q8IUB3	WF10B_HUMAN	WAP four-disulfide core domain 10B isoform a	31	WAP.					extracellular region	peptidase inhibitor activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GACCTTGATTCCTGAAATGAT	0.478													24	29					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44815477	44815477	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:44815477G>A	uc002xrm.2	-	8	1934	c.1533C>T	c.(1531-1533)GCC>GCT	p.A511A	CDH22_uc010ghk.1_Silent_p.A511A	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	511	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				GGCCTGGCTTGGCATCCTCGC	0.617													128	114					0	0	1	0	0
SULF2	55959	broad.mit.edu	37	20	46318953	46318953	+	Missense_Mutation	SNP	C	T	T	rs139603157		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:46318953C>T	uc002xto.2	-	5	984	c.654G>A	c.(652-654)ATG>ATA	p.M218I	SULF2_uc002xtr.2_Missense_Mutation_p.M218I|SULF2_uc002xtq.2_Missense_Mutation_p.M218I|SULF2_uc010ghv.1_Missense_Mutation_p.M218I	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	218					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						GGCTGATGACCATGAGGACTG	0.572													59	56					0	0	1	0	0
PREX1	57580	broad.mit.edu	37	20	47305233	47305233	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:47305233C>T	uc002xtw.1	-	10	1319	c.1296G>A	c.(1294-1296)CGG>CGA	p.R432R		NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	432	DEP 1.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity	p.R432Q(1)		lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			TCAGCTTTCTCCGGCGGTCCT	0.562													20	77					0	0	1	0	0
DDX27	55661	broad.mit.edu	37	20	47855819	47855819	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:47855819T>C	uc002xuh.2	+	16	1995	c.1934T>C	c.(1933-1935)GTC>GCC	p.V645A		NM_017895	NP_060365	Q96GQ7	DDX27_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	645						nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			kidney(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GAGGCAGTGGTCCAAGAGCCC	0.418													9	46					0	0	1	0	0
PTGIS	5740	broad.mit.edu	37	20	48124592	48124592	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:48124592G>A	uc002xut.2	-	10	1422	c.1368C>T	c.(1366-1368)TTC>TTT	p.F456F	PTGIS_uc010zyi.1_Silent_p.F317F	NM_000961	NP_000952	Q16647	PTGIS_HUMAN	prostaglandin I2 synthase	456					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	CCAGCACAAGGAACACAAATC	0.562													18	86					0	0	1	0	0
PTPN1	5770	broad.mit.edu	37	20	49197870	49197870	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:49197870C>T	uc002xvl.2	+	9	1331	c.1157C>T	c.(1156-1158)TCC>TTC	p.S386F	PTPN1_uc010zys.1_Missense_Mutation_p.S313F	NM_002827	NP_002818	P18031	PTN1_HUMAN	protein tyrosine phosphatase, non-receptor type	386					blood coagulation|interferon-gamma-mediated signaling pathway|negative regulation of insulin receptor signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol|endoplasmic reticulum membrane	protein tyrosine phosphatase activity|zinc ion binding				0		Lung NSC(126;0.163)			Clodronate(DB00720)|Tiludronate(DB01133)	CAGGCTGCCTCCCCAGCCAAA	0.587													24	43					0	0	1	0	0
FAM65C	140876	broad.mit.edu	37	20	49225058	49225058	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:49225058C>T	uc002xvm.2	-	11	1130	c.812G>A	c.(811-813)CGG>CAG	p.R271Q	FAM65C_uc010zyt.1_Missense_Mutation_p.R275Q|FAM65C_uc010zyu.1_RNA|FAM65C_uc002xvn.1_Missense_Mutation_p.R271Q	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	271										ovary(2)	2						GCCCAGGCCCCGCAACTCCGT	0.682													103	120					0	0	1	0	0
CYP24A1	1591	broad.mit.edu	37	20	52773722	52773722	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:52773722C>T	uc002xwv.2	-	11	1939	c.1541G>A	c.(1540-1542)CGA>CAA	p.R514Q	CYP24A1_uc002xwu.1_Missense_Mutation_p.R372Q|CYP24A1_uc002xww.2_Missense_Mutation_p.R448Q	NM_000782	NP_000773	Q07973	CP24A_HUMAN	cytochrome P450 family 24 subfamily A	514					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	GGCGTATTATCGCTGGCAAAA	0.408													15	18					0	0	1	0	0
DOK5	55816	broad.mit.edu	37	20	53205048	53205048	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:53205048C>T	uc002xwy.2	+	3	421	c.201C>T	c.(199-201)AAC>AAT	p.N67N	DOK5_uc010gin.2_Translation_Start_Site|DOK5_uc002xwz.2_Translation_Start_Site	NM_018431	NP_060901	Q9P104	DOK5_HUMAN	docking protein 5	67	PH.						insulin receptor binding			ovary(1)	1			Colorectal(105;0.202)			ATGTGAAGAACGTAGCTCGAT	0.408													26	109					0	0	1	0	0
NPEPL1	79716	broad.mit.edu	37	20	57288560	57288560	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:57288560C>T	uc010zzs.1	+	9	1181	c.1086C>T	c.(1084-1086)GCC>GCT	p.A362A	NPEPL1_uc010zzr.1_Silent_p.A314A|NPEPL1_uc002xzn.2_RNA|NPEPL1_uc010gjo.1_Silent_p.A334A|NPEPL1_uc002xzp.2_3'UTR	NM_024663	NP_078939	Q8NDH3	PEPL1_HUMAN	aminopeptidase-like 1	362					proteolysis	cytoplasm	aminopeptidase activity|manganese ion binding|metalloexopeptidase activity				0	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;2.88e-09)|Colorectal(105;0.109)			ACCTGGGGGCCGACATCATCC	0.622													20	20					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57766169	57766169	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:57766169C>T	uc002yan.2	+	1	95	c.95C>T	c.(94-96)TCA>TTA	p.S32L		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	32	Pro-rich.					intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GGCCAGGCCTCACCTCACCTG	0.697													20	24					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57766995	57766995	+	Silent	SNP	G	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:57766995G>C	uc002yan.2	+	1	921	c.921G>C	c.(919-921)CCG>CCC	p.P307P		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	307						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					AGAAGTCGCCGACCGCCGGGA	0.701													12	24					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57768115	57768115	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:57768115C>T	uc002yan.2	+	1	2041	c.2041C>T	c.(2041-2043)CAT>TAT	p.H681Y		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	681						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GACCCCTGTCCATGAGGACAT	0.617													11	13					0	0	1	0	0
OSBPL2	9885	broad.mit.edu	37	20	60864340	60864340	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:60864340C>T	uc002yck.1	+	12	1405	c.1203C>T	c.(1201-1203)GAC>GAT	p.D401D	OSBPL2_uc002ycl.1_Silent_p.D389D|OSBPL2_uc011aah.1_Intron	NM_144498	NP_653081	Q9H1P3	OSBL2_HUMAN	oxysterol-binding protein-like protein 2 isoform	401					lipid transport		lipid binding			ovary(1)|central_nervous_system(1)	2	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			CACCCACGGACTGCCGCCTGC	0.597													16	21					0	0	1	0	0
SLCO4A1	28231	broad.mit.edu	37	20	61288114	61288114	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:61288114A>G	uc002ydb.1	+	2	513	c.308A>G	c.(307-309)AAG>AGG	p.K103R	SLCO4A1_uc002ydc.1_RNA	NM_016354	NP_057438	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family	103	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(1)	1	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			AACACGCCCAAGGGCATCCTG	0.652													31	48					0	0	1	0	0
NTSR1	4923	broad.mit.edu	37	20	61386057	61386057	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:61386057C>T	uc002ydf.2	+	2	1106	c.735C>T	c.(733-735)TTC>TTT	p.F245F		NM_002531	NP_002522	P30989	NTR1_HUMAN	neurotensin receptor 1	245	Helical; Name=5; (Potential).					endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			skin(2)|lung(1)|central_nervous_system(1)	4	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			TCATGTCCTTCATATTCCCCA	0.607													44	240					0	0	1	0	0
SLC17A9	63910	broad.mit.edu	37	20	61594944	61594944	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:61594944T>C	uc002yea.3	+	7	918	c.734T>C	c.(733-735)GTC>GCC	p.V245A	SLC17A9_uc002ydz.3_Missense_Mutation_p.V239A|SLC17A9_uc011aap.1_Missense_Mutation_p.V265A	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	245	Helical; (Potential).				exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						AGGGCAGCCGTCGTCTCCCAG	0.697													5	25					0	0	1	0	0
ZGPAT	84619	broad.mit.edu	37	20	62364624	62364624	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:62364624C>T	uc002ygk.2	+	3	816	c.638C>T	c.(637-639)CCA>CTA	p.P213L	ZGPAT_uc002ygi.2_Missense_Mutation_p.P213L|ZGPAT_uc002ygj.2_Missense_Mutation_p.P213L|ZGPAT_uc010gkk.1_Intron|ZGPAT_uc010gkl.1_Missense_Mutation_p.P213L|ZGPAT_uc002ygm.2_Missense_Mutation_p.P213L|ZGPAT_uc002ygn.3_RNA|LIME1_uc011abi.1_5'Flank	NM_032527	NP_115916	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	213					negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					TTCCAGGACCCAGACCTGAGC	0.677													30	35					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62839353	62839353	+	Silent	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:62839353A>G	uc002yii.2	+	7	1168	c.804A>G	c.(802-804)GAA>GAG	p.E268E	MYT1_uc002yih.2_Intron|MYT1_uc002yij.2_5'UTR	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	268	Glu-rich.				cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					aggaggaggaagaggaggagg	0.199													2	9					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62871785	62871785	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr20:62871785G>A	uc002yii.2	+	23	3714	c.3350G>A	c.(3349-3351)AGG>AAG	p.R1117K	MYT1_uc002yij.2_Missense_Mutation_p.R776K|MYT1_uc002yik.2_Missense_Mutation_p.R83K	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	1117					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					CAGGCTGTGAGGGGCATCCAG	0.602													40	54					0	0	1	0	0
LIPI	149998	broad.mit.edu	37	21	15537565	15537565	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr21:15537565C>T	uc002yjm.2	-	6	953	c.943G>A	c.(943-945)GAA>AAA	p.E315K	LIPI_uc010gkw.1_Missense_Mutation_p.E218K	NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	294					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		CATGATTTTTCCTTAAAACAG	0.318													37	36					0	0	1	0	0
CHODL	140578	broad.mit.edu	37	21	19629404	19629404	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr21:19629404G>A	uc002ykv.2	+	3	898	c.507G>A	c.(505-507)AGG>AGA	p.R169R	CHODL_uc002ykr.2_Silent_p.R128R|CHODL_uc002yks.2_Silent_p.R128R|CHODL_uc002ykt.2_Silent_p.R128R|CHODL_uc002yku.2_Silent_p.R128R	NM_024944	NP_079220	Q9H9P2	CHODL_HUMAN	chondrolectin precursor	169	Extracellular (Potential).|C-type lectin.				muscle organ development	integral to membrane|perinuclear region of cytoplasm	sugar binding			upper_aerodigestive_tract(1)	1		all_epithelial(11;0.21)		Epithelial(23;0.000191)|all cancers(11;0.000827)|LUSC - Lung squamous cell carcinoma(23;0.00646)|Lung(58;0.0129)|OV - Ovarian serous cystadenocarcinoma(11;0.017)|COAD - Colon adenocarcinoma(22;0.03)|Colorectal(24;0.0917)		ATGATGACAGGTGTAACATGA	0.403													7	88					0	0	1	0	0
RNF160	26046	broad.mit.edu	37	21	30357224	30357224	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr21:30357224C>T	uc002ymr.2	-	4	516	c.503G>A	c.(502-504)CGA>CAA	p.R168Q	RNF160_uc010gll.1_RNA	NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	122							ligase activity|zinc ion binding				0						TGTGGCTTCTCGGACGCGACG	0.358													17	18					0	0	1	0	0
KRTAP24-1	643803	broad.mit.edu	37	21	31654498	31654498	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr21:31654498C>T	uc002ynv.2	-	1	779	c.753G>A	c.(751-753)CTG>CTA	p.L251L		NM_001085455	NP_001078924	Q3LI83	KR241_HUMAN	keratin associated protein 24-1	251	6 X 10 AA repeats of Y-[ILR]-[SVPC]- [NRTS]-[SNTG]-X-[QHRP]-[PSY]-[QSL]-[SRK].|6.					keratin filament	structural molecule activity				0						AATAGCATTTCAGAGGTCTGC	0.428													8	77					0	0	1	0	0
KRTAP21-2	337978	broad.mit.edu	37	21	32119353	32119353	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr21:32119353G>A	uc011adh.1	-	1	168	c.168C>T	c.(166-168)GGC>GGT	p.G56G		NM_181617	NP_853648	Q3LI59	KR212_HUMAN	keratin associated protein 21-2	56						intermediate filament					0						catatccacagccagagccgt	0.189													22	50					0	0	1	0	0
HMGN1	3150	broad.mit.edu	37	21	40715075	40715075	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr21:40715075G>A	uc002yxo.2	-	6	470	c.266C>T	c.(265-267)TCT>TTT	p.S89F	HMGN1_uc002yxp.2_Silent_p.L53L|HMGN1_uc002yxq.2_Silent_p.L53L|HMGN1_uc002yxr.2_RNA	NM_004965	NP_004956	P05114	HMGN1_HUMAN	high-mobility group nucleosome binding domain 1	89					positive regulation of transcription elongation, DNA-dependent	chromatin|cytoplasm|nucleus	DNA binding			breast(1)	1		Prostate(19;8.69e-07)				TGCTTCATCAGAGGCTGGACT	0.368													22	51					0	0	1	0	0
MX2	4600	broad.mit.edu	37	21	42771212	42771212	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr21:42771212C>T	uc002yzf.1	+	10	1466	c.1362C>T	c.(1360-1362)ATC>ATT	p.I454I	MX2_uc002yzg.1_Silent_p.I177I|MX2_uc010gop.1_Intron	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	454					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				ACAACAAAATCAGAGAGGATT	0.393													26	68					0	0	1	0	0
MX1	4599	broad.mit.edu	37	21	42821111	42821111	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr21:42821111C>T	uc002yzh.2	+	16	2268	c.1321C>T	c.(1321-1323)CGT>TGT	p.R441C	MX1_uc002yzi.2_Missense_Mutation_p.R441C|MX1_uc010goq.2_Missense_Mutation_p.R441C	NM_001144925	NP_001138397	P20591	MX1_HUMAN	myxovirus resistance protein 1	441					induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				AAATCAGTATCGTGGTAGAGA	0.373													49	40					0	0	1	0	0
UMODL1	89766	broad.mit.edu	37	21	43524059	43524059	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr21:43524059G>A	uc002zaf.1	+	9	1381	c.1381G>A	c.(1381-1383)GGA>AGA	p.G461R	UMODL1_uc002zad.1_Missense_Mutation_p.G389R|UMODL1_uc002zae.1_Missense_Mutation_p.G389R|UMODL1_uc002zag.1_Missense_Mutation_p.G461R|UMODL1_uc010gow.1_Missense_Mutation_p.G253R|UMODL1_uc002zai.1_Missense_Mutation_p.G112R|UMODL1_uc010gox.1_RNA|UMODL1_uc010goy.1_Missense_Mutation_p.G112R|UMODL1_uc002zaj.1_RNA|UMODL1_uc010goz.1_Missense_Mutation_p.G206R|C21orf128_uc002zak.2_Silent_p.S58S	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	461	Extracellular (Potential).|SEA 1.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						TCTCCAGGCGGGAAGTGTGGT	0.602													116	124					0	0	1	0	0
UBASH3A	53347	broad.mit.edu	37	21	43833312	43833312	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr21:43833312G>A	uc002zbe.2	+	4	570	c.534G>A	c.(532-534)ACG>ACA	p.T178T	UBASH3A_uc002zbf.2_Silent_p.T178T|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Silent_p.T178T	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	178						cytosol|nucleus				ovary(3)	3						CCTTCGCCACGGAAGCATCTC	0.622													24	75					0	0	1	0	0
RRP1B	23076	broad.mit.edu	37	21	45089808	45089808	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr21:45089808C>T	uc002zdk.2	+	2	288	c.174C>T	c.(172-174)CTC>CTT	p.L58L		NM_015056	NP_055871	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1 homolog B	58					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.178)		GGAAGGGGCTCTTCTACTGCA	0.453													36	51					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45843526	45843526	+	Splice_Site	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr21:45843526A>G	uc002zet.1	+	24	3675	c.3462_splice	c.e24-2	p.K1154_splice	TRPM2_uc002zeu.1_Splice_Site_p.K1154_splice|TRPM2_uc002zew.1_Splice_Site_p.K1154_splice|TRPM2_uc010gpt.1_Splice_Site_p.R1204_splice|TRPM2_uc002zex.1_Splice_Site_p.K940_splice|TRPM2_uc002zey.1_Splice_Site_p.K667_splice|uc011afe.1_Intron|TRPM2_uc011aff.1_5'Flank	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,							integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TTCCTCTTTCAGGGTTGACGC	0.652													16	11					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47836465	47836465	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr21:47836465C>T	uc002zji.3	+	30	6740	c.6633C>T	c.(6631-6633)CCC>CCT	p.P2211P	PCNT_uc002zjj.2_Silent_p.P2093P	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2211					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					AGGCTGGGCCCCGGAAGAGCC	0.617													39	56					0	0	1	0	0
DIP2A	23181	broad.mit.edu	37	21	47977514	47977514	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr21:47977514C>T	uc002zjo.2	+	31	3829	c.3646C>T	c.(3646-3648)CAA>TAA	p.Q1216*	DIP2A_uc011afz.1_Nonsense_Mutation_p.Q1212*|DIP2A_uc002zjr.2_Nonsense_Mutation_p.Q183*	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	1216					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		CTCGGGACACCAATCAGTGCT	0.637													25	67					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17073356	17073356	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:17073356C>T	uc002zlp.1	-	1	345	c.85G>A	c.(85-87)GAG>AAG	p.E29K		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	29					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TGGGGCTCCTCCTCTTCTGGA	0.662													44	59					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18301315	18301315	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:18301315G>A	uc002zng.3	-	26	4465	c.4112C>T	c.(4111-4113)TCC>TTC	p.S1371F	MICAL3_uc011agl.1_Missense_Mutation_p.S1287F|MICAL3_uc010gre.1_5'Flank	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	1371	Pro-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		ATCCTGGGGGGACTTTTCAAC	0.637													116	151					0	0	1	0	0
CLTCL1	8218	broad.mit.edu	37	22	19184164	19184164	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:19184164G>A	uc002zpb.2	-	26	3952	c.3877C>T	c.(3877-3879)CGT>TGT	p.R1293C	CLTCL1_uc011agv.1_Missense_Mutation_p.R1293C|CLTCL1_uc011agw.1_Missense_Mutation_p.R1272C|CLTCL1_uc011agt.1_Missense_Mutation_p.R84C|CLTCL1_uc011agu.1_Missense_Mutation_p.R84C|CLTCL1_uc010grm.1_Missense_Mutation_p.R53C|CLTCL1_uc002zpe.2_3'UTR|CLTCL1_uc002zpd.1_Missense_Mutation_p.R200C	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	1293	Involved in binding clathrin light chain (By similarity).|Proximal segment.|Heavy chain arm.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					AAGTAGCCACGATCCTAGCAG	0.622			T	?	ALCL								17	21					0	0	1	0	0
DGCR8	54487	broad.mit.edu	37	22	20073953	20073953	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:20073953G>A	uc002zri.2	+	2	817	c.467G>A	c.(466-468)AGT>AAT	p.S156N	DGCR8_uc010grz.2_Missense_Mutation_p.S156N|DGCR8_uc002zrj.2_5'Flank	NM_022720	NP_073557	Q8WYQ5	DGCR8_HUMAN	DiGeorge syndrome critical region gene 8	156	Necessary for nuclear localization and retention.|Necessary for interaction with NCL.				primary miRNA processing	cytoplasm|cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding				0	Colorectal(54;0.0993)					AGCCCTGTCAGTGGGGACGTG	0.587													165	179					0	0	1	0	0
RTN4R	65078	broad.mit.edu	37	22	20230341	20230341	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:20230341G>A	uc002zrv.2	-	2	516	c.315C>T	c.(313-315)GCC>GCT	p.A105A	RTN4R_uc002zru.2_5'UTR	NM_023004	NP_075380	Q9BZR6	RTN4R_HUMAN	reticulon 4 receptor precursor	105					axonogenesis|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	anchored to membrane|cell surface|endoplasmic reticulum|plasma membrane	protein binding|receptor activity				0	Colorectal(54;0.0993)					GCTCCAGGAGGGCCAGGCCAG	0.647													16	83					0	0	1	0	0
PI4KA	5297	broad.mit.edu	37	22	21087380	21087380	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:21087380G>A	uc002zsz.3	-	36	4224	c.3993C>T	c.(3991-3993)CCC>CCT	p.P1331P	PI4KA_uc002zsy.3_Silent_p.P141P	NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	1331					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			GGAACTTTGGGGGACAGCTTC	0.488													35	72					0	0	1	0	0
LOC96610	96610	broad.mit.edu	37	22	23214022	23214022	+	RNA	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:23214022G>A	uc011aim.1	+	326		c.14099G>A								Parts of antibodies, mostly variable regions.												0						CAGAGACCAGGGAGGTCCCCC	0.572													101	169					0	0	1	0	0
RTDR1	27156	broad.mit.edu	37	22	23401775	23401775	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:23401775C>T	uc002zwt.2	-	7	1070	c.912G>A	c.(910-912)GAG>GAA	p.E304E		NM_014433	NP_055248	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region protein 1	304							binding			ovary(1)	1	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		CCTTGCGGCCCTCGGGGGCCT	0.647													20	76					0	0	1	0	0
ZDHHC8P1	150244	broad.mit.edu	37	22	23742681	23742681	+	RNA	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:23742681C>T	uc002zxa.3	-	3		c.455G>A			ZDHHC8P1_uc002zxb.3_RNA|ZDHHC8P1_uc002zwz.3_RNA	NR_003950				Homo sapiens cDNA FLJ31568 fis, clone NT2RI2001595.												0						CCCCCGGGCCCATAGTCAGGG	0.622													11	7					0	0	1	0	0
GGT1	2678	broad.mit.edu	37	22	25023936	25023936	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:25023936C>T	uc003aan.1	+	13	1813	c.1326C>T	c.(1324-1326)TTC>TTT	p.F442F	GGT1_uc003aas.1_Silent_p.F442F|GGT1_uc003aat.1_Silent_p.F442F|GGT1_uc003aau.1_Silent_p.F442F|GGT1_uc003aav.1_Silent_p.F442F|GGT1_uc003aaw.1_Silent_p.F442F|GGT1_uc003aax.1_Silent_p.F442F|GGT1_uc003aay.1_Silent_p.F98F	NM_013430	NP_038347	P19440	GGT1_HUMAN	gamma-glutamyltransferase 1 precursor	442	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding				0					Glutathione(DB00143)	CTGCCAATTTCATCCAGCCAG	0.627													140	173					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25270530	25270530	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:25270530G>A	uc003abg.2	+	13	1597	c.1440G>A	c.(1438-1440)CCG>CCA	p.P480P	SGSM1_uc003abh.2_Silent_p.P480P|SGSM1_uc010guu.1_Intron|SGSM1_uc003abj.2_Intron|SGSM1_uc003abi.1_Intron	NM_001039948	NP_001035037	Q2NKQ1	SGSM1_HUMAN	RUN and TBC1 domain containing 2 isoform 1	480						Golgi apparatus	Rab GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)	5						CGCCAAGCCCGAAGGAGCAGC	0.632													9	10					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26422411	26422411	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:26422411G>A	uc003abz.1	+	43	6721	c.6471G>A	c.(6469-6471)AGG>AGA	p.R2157R	MYO18B_uc003aca.1_Silent_p.R2038R|MYO18B_uc010guy.1_Silent_p.R2039R|MYO18B_uc010guz.1_Silent_p.R2037R|MYO18B_uc011aka.1_Silent_p.R1311R|MYO18B_uc011akb.1_Silent_p.R1670R|MYO18B_uc010gva.1_Silent_p.R140R|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2157						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CTTGGCACAGGATAAACGAAG	0.488													109	164					0	0	1	0	0
GAS2L1	10634	broad.mit.edu	37	22	29704556	29704557	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:29704556_29704557CC>TT	uc003afa.1	+	2	660_661	c.461_462CC>TT	c.(460-462)GCC>GTT	p.A154V	GAS2L1_uc010gvm.1_Missense_Mutation_p.A154V|GAS2L1_uc003afb.1_Missense_Mutation_p.A154V|GAS2L1_uc003afc.1_Missense_Mutation_p.A154V|GAS2L1_uc003afd.1_Missense_Mutation_p.A154V|GAS2L1_uc003afe.1_Missense_Mutation_p.A154V	NM_152236	NP_689422	Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1 isoform a	154					cell cycle arrest	cytoplasm|cytoskeleton					0						GGCCTGCTGGCCCCACGCCTCG	0.673													8	15					0	0	1	0	0
AP1B1	162	broad.mit.edu	37	22	29737602	29737602	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:29737602C>T	uc003afj.2	-	13	1868	c.1684G>A	c.(1684-1686)GAG>AAG	p.E562K	AP1B1_uc003afi.2_Missense_Mutation_p.E562K|AP1B1_uc003afk.2_Missense_Mutation_p.E562K|AP1B1_uc003afl.2_Missense_Mutation_p.E562K|AP1B1_uc011ako.1_Missense_Mutation_p.E115K	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	562					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						CAGATAAGCTCGTCTAACAGT	0.617													19	147					0	0	1	0	0
CCDC157	550631	broad.mit.edu	37	22	30771580	30771580	+	Silent	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:30771580A>G	uc011aku.1	+	10	2445	c.1785A>G	c.(1783-1785)CTA>CTG	p.L595L	CCDC157_uc011akv.1_Silent_p.L595L|uc003aho.1_5'Flank	NM_001017437	NP_001017437	Q569K6	CC157_HUMAN	coiled-coil domain containing 157	595	Potential.									central_nervous_system(1)	1						TCCGGGTCCTACAGGAGGAGA	0.607													17	80					0	0	1	0	0
LARGE	9215	broad.mit.edu	37	22	33733715	33733715	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:33733715G>A	uc003and.3	-	11	1783	c.1204C>T	c.(1204-1206)CTG>TTG	p.L402L	LARGE_uc011amd.1_Silent_p.L201L|LARGE_uc003ane.3_Silent_p.L402L|LARGE_uc010gwp.2_Intron|LARGE_uc011ame.1_Silent_p.L334L|LARGE_uc011amf.1_Silent_p.L402L|LARGE_uc010gwq.1_RNA	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	402	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				AGGAAGGTCAGGTAGAGGTTG	0.532													48	55					0	0	1	0	0
SH3BP1	23616	broad.mit.edu	37	22	38051524	38051524	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:38051524C>T	uc003ati.2	+	18	2050	c.1939C>T	c.(1939-1941)CCA>TCA	p.P647S	SH3BP1_uc003atg.1_Intron|SH3BP1_uc003ath.1_Intron|SH3BP1_uc003atj.1_Intron|SH3BP1_uc003atk.1_Intron|uc003atl.1_Intron	NM_018957	NP_061830	Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1	647					signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					CCCGGCCTCCCCAGGTCCAGC	0.706													6	18					0	0	1	0	0
SOX10	6663	broad.mit.edu	37	22	38370059	38370059	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:38370059T>C	uc003aun.1	-	4	1122	c.844A>G	c.(844-846)AGC>GGC	p.S282G	POLR2F_uc003aum.2_Intron|SOX10_uc003auo.1_Missense_Mutation_p.S282G	NM_006941	NP_008872	P56693	SOX10_HUMAN	SRY (sex determining region Y)-box 10	282						cytoplasm|nucleus	DNA binding|identical protein binding|transcription coactivator activity				0	Melanoma(58;0.045)					ACCTCGTGGCTGATCTCACCA	0.617													10	335					0	0	1	0	0
DMC1	11144	broad.mit.edu	37	22	38948707	38948707	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:38948707G>A	uc003avz.1	-	7	560	c.385C>T	c.(385-387)CGT>TGT	p.R129C	DMC1_uc011anv.1_Missense_Mutation_p.R129C|DMC1_uc003awa.1_Missense_Mutation_p.R129C	NM_007068	NP_008999	Q14565	DMC1_HUMAN	DMC1 dosage suppressor of mck1 homolog	129	ATP (Potential).				reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			ovary(1)	1	Melanoma(58;0.0286)					TTTCCAGTACGAAATTCTGTG	0.274								Homologous_recombination					17	31					0	0	1	0	0
SUN2	25777	broad.mit.edu	37	22	39132377	39132377	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:39132377C>T	uc003awh.1	-	19	2333	c.2049G>A	c.(2047-2049)ACG>ACA	p.T683T	SUN2_uc011anz.1_Silent_p.T718T|SUN2_uc011aoa.1_Silent_p.T672T|SUN2_uc003awi.1_Silent_p.T683T|SUN2_uc010gxq.1_Silent_p.T704T|SUN2_uc010gxr.1_Silent_p.T683T|SUN2_uc010gxs.1_Intron	NM_015374	NP_056189	Q9UH99	SUN2_HUMAN	unc-84 homolog B	683	SUN.|Perinuclear space.				centrosome localization|cytoskeletal anchoring at nuclear membrane|mitotic spindle organization|nuclear envelope organization|nuclear matrix anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	endosome membrane|integral to membrane|nuclear inner membrane|SUN-KASH complex	lamin binding|microtubule binding			large_intestine(1)|skin(1)	2						ACGTGGCCATCGTAGGGGCCT	0.612													10	31					0	0	1	0	0
CBX7	23492	broad.mit.edu	37	22	39530418	39530418	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:39530418G>A	uc003axb.2	-	5	675	c.586C>T	c.(586-588)CCT>TCT	p.P196S	CBX7_uc003axc.2_Missense_Mutation_p.P103S	NM_175709	NP_783640	O95931	CBX7_HUMAN	chromobox homolog 7	196					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex				ovary(1)	1	Melanoma(58;0.04)					TCCTCTTCAGGGGGCTGCGCA	0.478													6	17					0	0	1	0	0
TAB1	10454	broad.mit.edu	37	22	39811541	39811541	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:39811541C>T	uc003axt.2	+	3	256	c.207C>T	c.(205-207)AAC>AAT	p.N69N	TAB1_uc003axr.2_Silent_p.N145N|TAB1_uc011aok.1_Translation_Start_Site|TAB1_uc003axu.1_Silent_p.N69N	NM_006116	NP_006107	Q15750	TAB1_HUMAN	mitogen-activated protein kinase kinase kinase 7	69	PP2C-like.				activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)	1						GGGTCTTCAACGGCTATGATG	0.622													19	136					0	0	1	0	0
ATF4	468	broad.mit.edu	37	22	39918231	39918231	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:39918231C>T	uc003axz.2	+	3	960	c.680C>T	c.(679-681)TCC>TTC	p.S227F	ATF4_uc011aol.1_Missense_Mutation_p.S139F|ATF4_uc003aya.2_Missense_Mutation_p.S227F	NM_182810	NP_877962	P18848	ATF4_HUMAN	activating transcription factor 4	227					cellular amino acid metabolic process|gluconeogenesis|positive regulation of transcription from RNA polymerase II promoter|response to endoplasmic reticulum stress|transcription from RNA polymerase II promoter	cytoplasm|plasma membrane	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Melanoma(58;0.04)					AGCCCAGAGTCCTATCTGGGG	0.542													8	13					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40061888	40061888	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:40061888C>T	uc003ayc.2	+	23	3981	c.3981C>T	c.(3979-3981)CTC>CTT	p.L1327L	CACNA1I_uc003ayd.2_Silent_p.L1292L|CACNA1I_uc003aye.2_Silent_p.L1242L|CACNA1I_uc003ayf.2_Silent_p.L1207L	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1327	Extracellular (Potential).|III.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	TTCCCCAGCTCTTCAAGGGCA	0.572													134	208					0	0	1	0	0
TEF	7008	broad.mit.edu	37	22	41783607	41783607	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:41783607C>T	uc003azy.2	+	2	496	c.410C>T	c.(409-411)TCC>TTC	p.S137F	TEF_uc003azx.2_Missense_Mutation_p.S107F|TEF_uc011apa.1_Missense_Mutation_p.S142F	NM_003216	NP_003207	Q10587	TEF_HUMAN	thyrotrophic embryonic factor isoform 1	137					rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCCAGCTCTTCCACAGCATCC	0.612													51	46					0	0	1	0	0
ARFGAP3	26286	broad.mit.edu	37	22	43218407	43218408	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:43218407_43218408GG>AA	uc003bdd.2	-	9	900_901	c.680_681CC>TT	c.(679-681)GCC>GTT	p.A227V	ARFGAP3_uc010gzf.2_Missense_Mutation_p.A183V|ARFGAP3_uc011apu.1_Missense_Mutation_p.A155V	NM_014570	NP_055385	Q9NP61	ARFG3_HUMAN	ADP-ribosylation factor GTPase activating	227					intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	cytosol|Golgi membrane	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(1)	1						TTCCTTTTTTGGCCCCAAGCTA	0.332													59	68					0	0	1	0	0
PRR5-ARHGAP8	553158	broad.mit.edu	37	22	45241179	45241180	+	Missense_Mutation	DNP	CC	TT	TT	rs147582478	byFrequency	TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:45241179_45241180CC>TT	uc003bfd.2	+	13	1529_1530	c.1257_1258CC>TT	c.(1255-1260)ATCCCC>ATTTCC	p.P420S	PRR5-ARHGAP8_uc003bfc.2_Missense_Mutation_p.P341S|PRR5-ARHGAP8_uc011aqi.1_Missense_Mutation_p.P332S|PRR5-ARHGAP8_uc011aqj.1_Missense_Mutation_p.P246S|ARHGAP8_uc003bfi.2_Missense_Mutation_p.P210S|ARHGAP8_uc010gzv.2_Missense_Mutation_p.P210S|ARHGAP8_uc003bfj.2_Missense_Mutation_p.P241S|ARHGAP8_uc003bfk.2_Missense_Mutation_p.P210S|ARHGAP8_uc003bfl.2_RNA	NM_181335	NP_851852			Rho GTPase activating protein 8 isoform 2											skin(2)	2						GCGAACTCATCCCCCCTGTGCT	0.535													62	62					0	0	1	0	0
PHF21B	112885	broad.mit.edu	37	22	45316363	45316363	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:45316363C>T	uc003bfn.2	-	3	279	c.128G>A	c.(127-129)GGA>GAA	p.G43E	PHF21B_uc003bfm.2_5'UTR|PHF21B_uc011aqk.1_Missense_Mutation_p.G31E|PHF21B_uc011aql.1_Missense_Mutation_p.G43E|PHF21B_uc011aqm.1_Missense_Mutation_p.G31E	NM_138415	NP_612424	Q96EK2	PF21B_HUMAN	PHD finger protein 21B isoform 1	43							zinc ion binding			ovary(2)|skin(1)	3		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		AGTGATCGTTCCCAAAGCCTG	0.627													12	36					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46792594	46792594	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:46792594C>T	uc003bhw.1	-	13	5751	c.5751G>A	c.(5749-5751)GAG>GAA	p.E1917E	CELSR1_uc011arc.1_Silent_p.E238E	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1917	Extracellular (Potential).|EGF-like 6; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CCCCCATGTTCTCGCAGGGGT	0.607													13	17					0	0	1	0	0
LMF2	91289	broad.mit.edu	37	22	50944159	50944159	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:50944159T>C	uc003blp.2	-	6	891	c.860A>G	c.(859-861)GAC>GGC	p.D287G	LMF2_uc010hba.2_Missense_Mutation_p.D109G|LMF2_uc003blo.2_Missense_Mutation_p.D262G|NCAPH2_uc003blq.3_5'Flank|NCAPH2_uc003blv.2_5'Flank|NCAPH2_uc003blr.3_5'Flank|NCAPH2_uc010hbb.2_5'Flank|NCAPH2_uc003blu.3_5'Flank|NCAPH2_uc003bls.3_5'Flank|NCAPH2_uc003blt.3_5'Flank|NCAPH2_uc003blw.3_5'Flank|NCAPH2_uc003blx.3_5'Flank|NCAPH2_uc003bly.3_5'Flank	NM_033200	NP_149977	Q9BU23	LMF2_HUMAN	lipase maturation factor 2	287						endoplasmic reticulum membrane|integral to membrane				breast(1)	1		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GTGCTGGTCGTCCAGCAGCGC	0.642													4	65					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4777018	4777018	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:4777018G>A	uc003bqa.2	+	41	5728	c.5380G>A	c.(5380-5382)GGA>AGA	p.G1794R	ITPR1_uc010hca.1_Missense_Mutation_p.G1779R|ITPR1_uc011asu.1_Intron|ITPR1_uc003bqc.2_Missense_Mutation_p.G764R	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	1842	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CCTTCTGGAAGGAGGCAACAC	0.547													48	8					0	0	1	0	0
IQSEC1	9922	broad.mit.edu	37	3	12978122	12978122	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:12978122G>A	uc003bxt.2	-	3	445	c.436C>T	c.(436-438)CGC>TGC	p.R146C	IQSEC1_uc003bxu.3_Missense_Mutation_p.R24C|IQSEC1_uc011auw.1_Missense_Mutation_p.R132C	NM_014869	NP_055684	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1 isoform b	146	IQ.				regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1						TGGTACTGGCGAAACGCCGTC	0.582													3	4					0	0	1	0	0
WNT7A	7476	broad.mit.edu	37	3	13916456	13916456	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:13916456C>T	uc003bye.1	-	2	591	c.286G>A	c.(286-288)GAG>AAG	p.E96K		NM_004625	NP_004616	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family,	96					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			ovary(2)|breast(1)	3						ACTTTGAGCTCCTTCCCGAAG	0.587													24	2					0	0	1	0	0
SLC6A6	6533	broad.mit.edu	37	3	14508048	14508048	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:14508048C>T	uc010heg.2	+	14	1048	c.757C>T	c.(757-759)CCA>TCA	p.P253S	SLC6A6_uc003byq.2_Missense_Mutation_p.P253S|SLC6A6_uc003byr.2_RNA	NM_001134367	NP_001127839	P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter	253	Helical; Name=5; (Potential).				cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			ovary(1)	1						AGCCACTTTTCCATTCGCCAT	0.567													96	20					0	0	1	0	0
STT3B	201595	broad.mit.edu	37	3	31617941	31617941	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:31617941T>C	uc011axe.1	+	2	368	c.368T>C	c.(367-369)TTA>TCA	p.L123S	STT3B_uc010hft.1_Missense_Mutation_p.L123S|STT3B_uc003cer.1_Missense_Mutation_p.L123S	NM_178862	NP_849193	Q8TCJ2	STT3B_HUMAN	source of immunodominant MHC-associated	123					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding				0						TATGAATTTTTAAATTGGTTT	0.289													27	8					0	0	1	0	0
ZNF860	344787	broad.mit.edu	37	3	32031962	32031962	+	Missense_Mutation	SNP	A	G	G	rs1808125	by1000genomes	TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:32031962A>G	uc011axg.1	+	2	1940	c.1391A>G	c.(1390-1392)CAT>CGT	p.H464R		NM_001137674	NP_001131146	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	464	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AAGACCTTCCATCACAATTCA	0.418													7	86					0	0	1	0	0
UBP1	7342	broad.mit.edu	37	3	33451019	33451019	+	Silent	SNP	A	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:33451019A>T	uc003cfq.3	-	6	1160	c.630T>A	c.(628-630)GTT>GTA	p.V210V	UBP1_uc003cfr.3_Silent_p.V210V|UBP1_uc010hga.2_Silent_p.V210V	NM_014517	NP_055332	Q9NZI7	UBIP1_HUMAN	upstream binding protein 1 (LBP-1a) isoform a	210					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			kidney(2)	2						TAAAGGTGTCAACCTGGATCC	0.438													49	5					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35729256	35729256	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:35729256G>A	uc003cgb.2	+	6	551	c.287G>A	c.(286-288)AGT>AAT	p.S96N	ARPP21_uc003cga.2_Missense_Mutation_p.S96N|ARPP21_uc011axy.1_Missense_Mutation_p.S96N|ARPP21_uc003cgf.2_5'Flank	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	96						cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						CAGCTTTCCAGTTTTTCCAGC	0.363													3	0					0	0	1	0	0
CCR8	1237	broad.mit.edu	37	3	39373934	39373934	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:39373934C>T	uc010hhr.2	+	2	250	c.112C>T	c.(112-114)CTT>TTT	p.L38F	CCR8_uc003cjm.2_Intron	NM_005201	NP_005192	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	38	Helical; Name=1; (Potential).				cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			ovary(1)|lung(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		CAAGTTGCTCCTTGCTGTCTT	0.478													70	7					0	0	1	0	0
MYRIP	25924	broad.mit.edu	37	3	40293465	40293465	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:40293465G>A	uc003cka.2	+	16	2657	c.2522G>A	c.(2521-2523)AGG>AAG	p.R841K	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Missense_Mutation_p.R776K|MYRIP_uc010hhw.2_Missense_Mutation_p.R752K|MYRIP_uc011ayz.1_Missense_Mutation_p.R654K|uc003ckb.2_Intron	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	841	Actin-binding.				intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		ACTAAGGAAAGGAAAGGCACC	0.408													5	11					0	0	1	0	0
ENTPD3	956	broad.mit.edu	37	3	40468952	40468952	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:40468952A>C	uc003ckd.3	+	11	1635	c.1543A>C	c.(1543-1545)AAG>CAG	p.K515Q	ENTPD3_uc010hhy.2_Missense_Mutation_p.K515Q|uc003cke.3_Intron	NM_001248	NP_001239	O75355	ENTP3_HUMAN	ectonucleoside triphosphate diphosphohydrolase	515	Cytoplasmic (Potential).					integral to membrane	ATP binding|hydrolase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0605)|Kidney(284;0.0758)		AACCAGAAGAAAGAGGCACTC	0.537													25	35					0	0	1	0	0
CCBP2	1238	broad.mit.edu	37	3	42906432	42906432	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:42906432C>T	uc003cme.2	+	3	617	c.438C>T	c.(436-438)ATC>ATT	p.I146I	CCBP2_uc003cmd.1_Intron|CCBP2_uc003cmf.2_Silent_p.I146I|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Intron	NM_001296	NP_001287	O00590	CCBP2_HUMAN	chemokine binding protein 2	146	Cytoplasmic (Potential).				chemotaxis|immune response|multicellular organismal development	integral to plasma membrane	C-X-C chemokine receptor activity			lung(4)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.241)		ACCTGGAGATCGTTCATGCTC	0.507													59	11					0	0	1	0	0
ZNF445	353274	broad.mit.edu	37	3	44490150	44490150	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:44490150G>A	uc003cnf.2	-	8	1361	c.1013C>T	c.(1012-1014)TCA>TTA	p.S338L	ZNF445_uc011azv.1_Missense_Mutation_p.S326L|ZNF445_uc011azw.1_Missense_Mutation_p.S338L	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	338					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		AGGACATCCTGATGACACAGC	0.403													33	8					0	0	1	0	0
TGM4	7047	broad.mit.edu	37	3	44938250	44938250	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:44938250C>T	uc003coc.3	+	6	672	c.599C>T	c.(598-600)TCC>TTC	p.S200F	TGM4_uc003cob.2_RNA	NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	200					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	ACTGAGAGCTCCCTCAAGCCC	0.512													95	9					0	0	1	0	0
MYL3	4634	broad.mit.edu	37	3	46899902	46899902	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:46899902C>T	uc003cql.1	-	5	624	c.531G>A	c.(529-531)GAG>GAA	p.E177E		NM_000258	NP_000249	P08590	MYL3_HUMAN	slow skeletal ventricular myosin alkali light	177	EF-hand 3.				cardiac muscle contraction|muscle filament sliding|positive regulation of ATPase activity|regulation of striated muscle contraction|regulation of the force of heart contraction|ventricular cardiac muscle tissue morphogenesis	A band|cytosol|I band|muscle myosin complex	actin monomer binding|calcium ion binding|myosin II heavy chain binding|structural constituent of muscle				0				BRCA - Breast invasive adenocarcinoma(193;0.00116)|KIRC - Kidney renal clear cell carcinoma(197;0.00557)|Kidney(197;0.0063)		CATTGGAGTCCTCTTGCCCAG	0.617													75	5					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48453376	48453376	+	Nonsense_Mutation	SNP	T	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:48453376T>A	uc003csw.2	-	28	5413	c.5143A>T	c.(5143-5145)AAG>TAG	p.K1715*	PLXNB1_uc003cst.2_Nonsense_Mutation_p.K165*|PLXNB1_uc003csu.2_Nonsense_Mutation_p.K1532*|PLXNB1_uc003csx.2_Nonsense_Mutation_p.K1715*	NM_002673	NP_002664	O43157	PLXB1_HUMAN	plexin B1 precursor	1715	Cytoplasmic (Potential).				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ACTTGGTGCTTAATCCCTCGA	0.572													170	30					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48698213	48698213	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:48698213G>A	uc003cul.2	-	1	2136	c.1855C>T	c.(1855-1857)CGC>TGC	p.R619C	CELSR3_uc003cuf.1_Missense_Mutation_p.R689C	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	619	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCCCTGATGCGCAAGGCATAC	0.587													8	22					0	0	1	0	0
TRAIP	10293	broad.mit.edu	37	3	49877783	49877783	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:49877783C>T	uc003cxs.1	-	9	835	c.729G>A	c.(727-729)TTG>TTA	p.L243L	TRAIP_uc010hla.1_Silent_p.L144L	NM_005879	NP_005870	Q9BWF2	TRAIP_HUMAN	TRAF interacting protein	243	Interaction with CYLD.|Potential.				cell proliferation|induction of apoptosis	perinuclear region of cytoplasm	protein binding|zinc ion binding			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGGCCTGATCCAATTCAGAGT	0.517													64	6					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52422287	52422287	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:52422287C>T	uc011bef.1	+	57	9369	c.9108C>T	c.(9106-9108)ATC>ATT	p.I3036I	DNAH1_uc003ddv.2_5'UTR	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3036	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GCACCTCCATCTGCCAGTGGG	0.602													4	14					0	0	1	0	0
TMEM110	375346	broad.mit.edu	37	3	52883814	52883814	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:52883814C>T	uc003dge.2	-	4	502	c.421G>A	c.(421-423)GAA>AAA	p.E141K	TMEM110_uc003dgc.3_Missense_Mutation_p.E141K	NM_198563	NP_940965	Q86TL2	TM110_HUMAN	transmembrane protein 110	141						integral to membrane				large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.72e-05)|Kidney(197;0.000777)|KIRC - Kidney renal clear cell carcinoma(197;0.000915)|OV - Ovarian serous cystadenocarcinoma(275;0.0541)		TTACCATATTCGCCGAAGCGC	0.627													39	9					0	0	1	0	0
SYNPR	132204	broad.mit.edu	37	3	63601104	63601104	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:63601104G>A	uc003dlq.2	+	5	1114	c.745G>A	c.(745-747)GAT>AAT	p.D249N	SYNPR_uc003dlp.2_Missense_Mutation_p.D269N|SYNPR_uc011bfk.1_RNA|SYNPR_uc011bfl.1_RNA|SYNPR_uc010hnt.2_Missense_Mutation_p.D258N|SYNPR_uc011bfm.1_RNA	NM_144642	NP_653243	Q8TBG9	SYNPR_HUMAN	synaptoporin isoform 2	249	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	transporter activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000918)|KIRC - Kidney renal clear cell carcinoma(15;0.0658)|Kidney(15;0.0904)		GCCAACCTCAGATGAGTTTGG	0.493													15	3					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77623762	77623762	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:77623762G>A	uc003dpy.3	+	14	2727	c.2084G>A	c.(2083-2085)CGA>CAA	p.R695Q	ROBO2_uc003dpz.2_Missense_Mutation_p.R699Q|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.R699Q	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	695	Fibronectin type-III 2.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CCGACTGAACGAAGTGCTGTC	0.443													20	4					0	0	1	0	0
OR5H1	26341	broad.mit.edu	37	3	97851967	97851967	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:97851967C>T	uc011bgt.1	+	1	426	c.426C>T	c.(424-426)ATC>ATT	p.I142I		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	142	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						GACTGTGCATCCGGCTATTAA	0.393													54	105					0	0	1	0	0
OR5H2	79310	broad.mit.edu	37	3	98002537	98002537	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:98002537C>T	uc003dsj.1	+	1	806	c.806C>T	c.(805-807)TCT>TTT	p.S269F		NM_001005482	NP_001005482	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H,	269	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						CGCCCTGCATCTCCACAAGCA	0.393													24	30					0	0	1	0	0
FILIP1L	11259	broad.mit.edu	37	3	99569252	99569252	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:99569252C>T	uc003dtm.2	-	5	1731	c.1268G>A	c.(1267-1269)AGA>AAA	p.R423K	C3orf26_uc003dtk.1_Intron|C3orf26_uc003dtl.2_Intron|FILIP1L_uc003dto.2_Missense_Mutation_p.R423K|FILIP1L_uc010hpf.2_5'UTR|FILIP1L_uc010hpg.2_Missense_Mutation_p.R183K|FILIP1L_uc003dtn.2_Missense_Mutation_p.R183K|FILIP1L_uc003dtp.1_Missense_Mutation_p.R183K	NM_182909	NP_878913	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like isoform 1	423	Potential.					cytoplasm|membrane|myosin complex|nucleus				ovary(1)	1						AGCCATAATTCTTTTACTGAG	0.363													6	33					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100497169	100497169	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:100497169G>A	uc003dun.2	-	26	2244	c.2159C>T	c.(2158-2160)CCT>CTT	p.P720L	ABI3BP_uc003duj.2_Missense_Mutation_p.P300L|ABI3BP_uc003duk.2_Missense_Mutation_p.P429L|ABI3BP_uc003dul.2_Missense_Mutation_p.P550L|ABI3BP_uc011bhd.1_Missense_Mutation_p.P674L|ABI3BP_uc003dum.2_Missense_Mutation_p.P131L	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	720	Pro-rich.					extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						TGGTGGTAAAGGTTTTCTTCG	0.458													14	60					0	0	1	0	0
KIAA1407	57577	broad.mit.edu	37	3	113684069	113684069	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:113684069C>T	uc003eax.2	-	17	2891	c.2744G>A	c.(2743-2745)AGG>AAG	p.R915K		NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	915										ovary(2)	2						CTCGTGGTACCTTCCAGGTAC	0.403													25	55					0	0	1	0	0
RABL3	285282	broad.mit.edu	37	3	120417383	120417383	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:120417383G>A	uc003edx.2	-	5	451	c.421C>T	c.(421-423)CCA>TCA	p.P141S		NM_173825	NP_776186	Q5HYI8	RABL3_HUMAN	RAB, member of RAS oncogene family-like 3	141	Small GTPase-like.				small GTPase mediated signal transduction		GTP binding				0				GBM - Glioblastoma multiforme(114;0.151)		ACCAACAGTGGTATTTGGTTA	0.368													175	237					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121647371	121647371	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:121647371C>T	uc003eep.2	+	15	1463	c.1310C>T	c.(1309-1311)TCT>TTT	p.S437F	SLC15A2_uc011bjn.1_Missense_Mutation_p.S406F	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	437					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	GAAAACAATTCTCTGTTGATA	0.413													36	160					0	0	1	0	0
ILDR1	286676	broad.mit.edu	37	3	121720613	121720613	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:121720613C>T	uc003ees.2	-	4	584	c.478G>A	c.(478-480)GAA>AAA	p.E160K	ILDR1_uc003eeq.2_Missense_Mutation_p.E172K|ILDR1_uc003eer.2_Missense_Mutation_p.E160K|ILDR1_uc010hrg.2_Intron	NM_175924	NP_787120	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor	160	Extracellular (Potential).|Ig-like V-type.					cytosol|integral to membrane|plasma membrane	receptor activity			skin(1)	1				GBM - Glioblastoma multiforme(114;0.156)		AGCTTTACTTCCTTATCGGGG	0.458													58	84					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122002657	122002657	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:122002657T>C	uc003eev.3	+	7	2228	c.1856T>C	c.(1855-1857)TTT>TCT	p.F619S	CASR_uc003eew.3_Missense_Mutation_p.F629S	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	619	Helical; Name=1; (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CTCACCCTCTTTGCCGTGCTG	0.542													40	50					0	0	1	0	0
PARP9	83666	broad.mit.edu	37	3	122259599	122259599	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:122259599G>A	uc010hri.2	-	8	1735	c.1590C>T	c.(1588-1590)GCC>GCT	p.A530A	PARP9_uc003eff.3_Silent_p.A495A|PARP9_uc011bjs.1_Silent_p.A495A|PARP9_uc003efg.2_Silent_p.A75A|PARP9_uc003efi.2_Silent_p.A495A|PARP9_uc003efh.2_Silent_p.A530A|PARP9_uc003efj.2_Silent_p.A495A	NM_001146102	NP_001139574	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	530					cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)|pancreas(1)|prostate(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0519)		TCCATGCGTGGGCCTCATACA	0.453													77	115					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123452895	123452895	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:123452895G>A	uc003ego.2	-	10	1230	c.948C>T	c.(946-948)CCC>CCT	p.P316P	MYLK_uc011bjw.1_Silent_p.P316P|MYLK_uc003egp.2_Silent_p.P316P|MYLK_uc003egq.2_Silent_p.P316P|MYLK_uc003egr.2_Silent_p.P316P|MYLK_uc003egs.2_Silent_p.P140P	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	316					aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		ACTCCCTTGGGGGCTGAGGCT	0.642													14	51					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123512533	123512533	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:123512533G>A	uc003ego.2	-	4	438	c.156C>T	c.(154-156)TTC>TTT	p.F52F	MYLK_uc011bjw.1_Silent_p.F52F|MYLK_uc003egp.2_Silent_p.F52F|MYLK_uc003egq.2_Silent_p.F52F|MYLK_uc003egr.2_Silent_p.F52F|MYLK_uc003egs.2_5'UTR|MYLK_uc010hrs.1_Silent_p.F52F|MYLK_uc003egu.1_Silent_p.F62F	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	52	Ig-like C2-type 1.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CCCGCCCTTCGAACTTGGCGG	0.602													24	32					0	0	1	0	0
ROPN1B	152015	broad.mit.edu	37	3	125691007	125691007	+	Missense_Mutation	SNP	G	A	A	rs146745880		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:125691007G>A	uc003eih.2	+	2	338	c.110G>A	c.(109-111)GGG>GAG	p.G37E	ROPN1B_uc010hsb.2_Missense_Mutation_p.G37E|ROPN1B_uc011bkg.1_Missense_Mutation_p.G37E	NM_001012337	NP_001012337	Q9BZX4	ROP1B_HUMAN	ropporin, rhophilin associated protein 1B	37	RIIa.				acrosome reaction|cell-cell adhesion|cytokinesis|fusion of sperm to egg plasma membrane|Rho protein signal transduction|sperm motility|spermatogenesis	cytoplasm|flagellum	cAMP-dependent protein kinase regulator activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling complex scaffold activity				0				GBM - Glioblastoma multiforme(114;0.151)		ATCCAGTGGGGGGCCGAGTAC	0.617													35	42					0	0	1	0	0
CCDC37	348807	broad.mit.edu	37	3	126155217	126155217	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:126155217G>A	uc003eiu.1	+	17	1905	c.1806G>A	c.(1804-1806)GAG>GAA	p.E602E	CCDC37_uc010hsg.1_Silent_p.E603E	NM_182628	NP_872434	Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	602	Poly-Glu.									ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.166)		TGGACAAGGAGGAGGAGGAGC	0.527													37	58					0	0	1	0	0
MGLL	11343	broad.mit.edu	37	3	127441340	127441340	+	Nonsense_Mutation	SNP	A	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:127441340A>T	uc003ejx.2	-	4	447	c.302T>A	c.(301-303)TTG>TAG	p.L101*	MGLL_uc003ejw.2_Nonsense_Mutation_p.L111*|MGLL_uc011bko.1_Nonsense_Mutation_p.L111*|MGLL_uc010hsp.1_Nonsense_Mutation_p.L101*|MGLL_uc003ejv.2_Nonsense_Mutation_p.L75*	NM_001003794	NP_001003794	Q99685	MGLL_HUMAN	monoglyceride lipase isoform 2	101					arachidonic acid metabolic process|fatty acid biosynthetic process|inflammatory response|platelet activation|regulation of endocannabinoid signaling pathway|regulation of inflammatory response|regulation of sensory perception of pain|triglyceride catabolic process	plasma membrane	acylglycerol lipase activity|carboxylesterase activity|lysophospholipase activity|protein homodimerization activity				0						CACATGCTGCAACACATCCCT	0.537													38	95					0	0	1	0	0
MRPL3	11222	broad.mit.edu	37	3	131219361	131219361	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:131219361G>A	uc003eoh.2	-	3	446	c.282C>T	c.(280-282)TCC>TCT	p.S94S	MRPL3_uc011blo.1_5'UTR|MRPL3_uc011blp.1_Silent_p.S121S	NM_007208	NP_009139	P09001	RM03_HUMAN	mitochondrial ribosomal protein L3	94					translation	mitochondrial large ribosomal subunit	RNA binding|structural constituent of ribosome				0						CAACTCTAAAGGAACCTGGCA	0.398													25	43					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134670529	134670529	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:134670529C>T	uc003eqt.2	+	3	660	c.440C>T	c.(439-441)TCC>TTC	p.S147F	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_Missense_Mutation_p.S147F	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	147	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						GAGAGCTTCTCCCAGGTGGAC	0.493													73	105					0	0	1	0	0
PIK3CB	5291	broad.mit.edu	37	3	138384011	138384011	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:138384011G>A	uc011bmq.1	-	18	2539	c.2539C>T	c.(2539-2541)CGC>TGC	p.R847C	PIK3CB_uc011bmn.1_Missense_Mutation_p.R359C|PIK3CB_uc011bmo.1_Missense_Mutation_p.R298C|PIK3CB_uc011bmp.1_Missense_Mutation_p.R434C	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	847	PI3K/PI4K.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						AGGCCAGAGCGATCTCCTGTT	0.418													45	29					0	0	1	0	0
SPSB4	92369	broad.mit.edu	37	3	140866004	140866004	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:140866004G>A	uc003ett.2	+	3	969	c.715G>A	c.(715-717)GAC>AAC	p.D239N	SPSB4_uc010hum.2_3'UTR	NM_080862	NP_543138	Q96A44	SPSB4_HUMAN	splA/ryanodine receptor domain and SOCS box	239	SOCS box.				intracellular signal transduction	cytoplasm	protein binding				0						GCCACTGATGGACCTGTGCCG	0.627													35	33					0	0	1	0	0
HLTF	6596	broad.mit.edu	37	3	148792061	148792061	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:148792061C>T	uc003ewq.1	-	4	688	c.470G>A	c.(469-471)AGA>AAA	p.R157K	HLTF_uc003ewr.1_Missense_Mutation_p.R157K|HLTF_uc003ews.1_Missense_Mutation_p.R157K|HLTF_uc010hve.1_Missense_Mutation_p.R157K	NM_139048	NP_620636	Q14527	HLTF_HUMAN	helicase-like transcription factor	157					chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			AACCGCTTTTCTATTTTCTTC	0.338													21	23					0	0	1	0	0
FAM194A	131831	broad.mit.edu	37	3	150416638	150416638	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:150416638G>A	uc003eyg.2	-	3	550	c.493C>T	c.(493-495)CCA>TCA	p.P165S	FAM194A_uc003eyh.2_Missense_Mutation_p.P19S	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831	165										skin(2)|ovary(1)	3						ACTGATACTGGAATTCCTGGA	0.348													81	112					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151176362	151176362	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:151176362G>A	uc011bod.1	-	1	136	c.136C>T	c.(136-138)CGG>TGG	p.R46W		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	46	LRRNT.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTCAGGTACCGAAATGTGCAG	0.557													60	64					0	0	1	0	0
SGEF	26084	broad.mit.edu	37	3	153870694	153870694	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:153870694T>A	uc011bog.1	+	6	1671	c.1460T>A	c.(1459-1461)ATT>AAT	p.I487N	SGEF_uc011boh.1_Missense_Mutation_p.I487N	NM_015595	NP_056410	Q96DR7	ARHGQ_HUMAN	Src homology 3 domain-containing guanine	487	DH.				regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TTCTCCAATATTACAGATGTC	0.378													2	4					0	0	1	0	0
MFSD1	64747	broad.mit.edu	37	3	158539796	158539796	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:158539796C>T	uc003fcl.1	+	11	974	c.944C>T	c.(943-945)CCC>CTC	p.P315L	MFSD1_uc003fcm.1_RNA|MFSD1_uc003fcn.1_Missense_Mutation_p.P218L|MFSD1_uc011bow.1_Missense_Mutation_p.P276L|MFSD1_uc011box.1_Missense_Mutation_p.P242L	NM_022736	NP_073573	Q9H3U5	MFSD1_HUMAN	major facilitator superfamily domain containing	315	Helical; (Potential).				transmembrane transport	integral to membrane					0			Lung(72;0.00372)|LUSC - Lung squamous cell carcinoma(72;0.00523)			ATATCAGCTCCCATGTCCCCG	0.443													29	37					0	0	1	0	0
ARL14	80117	broad.mit.edu	37	3	160395517	160395517	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:160395517C>T	uc003fdq.2	+	1	570	c.383C>T	c.(382-384)CCT>CTT	p.P128L		NM_025047	NP_079323	Q8N4G2	ARL14_HUMAN	ADP-ribosylation factor-like 14	128					small GTPase mediated signal transduction	intracellular	GTP binding				0			Lung(72;7.02e-05)|LUSC - Lung squamous cell carcinoma(72;7.23e-05)			CAAGACATGCCTGGAGCTCTG	0.468													39	48					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164786915	164786915	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:164786915G>A	uc003fei.2	-	4	386	c.324C>T	c.(322-324)TTC>TTT	p.F108F		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	108	Lumenal.|P-type 1.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GATTATCAACGAAGAAGCACC	0.358										HNSCC(35;0.089)			39	42					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164906455	164906455	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:164906455C>T	uc003fej.3	-	2	2608	c.2164G>A	c.(2164-2166)GGT>AGT	p.G722S	SLITRK3_uc003fek.2_Missense_Mutation_p.G722S	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	722	Poly-Gly.|Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						GGTCGaccaccacccccactt	0.448										HNSCC(40;0.11)			55	34					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167031894	167031894	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:167031894G>A	uc003fep.2	-	16	1608	c.1285C>T	c.(1285-1287)CAT>TAT	p.H429Y	ZBBX_uc011bpc.1_Missense_Mutation_p.H429Y|ZBBX_uc003feq.2_Missense_Mutation_p.H400Y	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	429						intracellular	zinc ion binding			ovary(2)	2						TGACAATCATGAAAAGCACAA	0.289													8	24					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167240194	167240194	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:167240194C>T	uc003fev.1	-	12	1933	c.1627G>A	c.(1627-1629)GAA>AAA	p.E543K	WDR49_uc003feu.1_Missense_Mutation_p.E368K|WDR49_uc011bpd.1_Intron|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	543										large_intestine(1)|ovary(1)|skin(1)	3						AAAGAAATTTCCTTTTGAATC	0.318													11	20					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169540643	169540643	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:169540643C>T	uc003fgb.2	+	1	934	c.934C>T	c.(934-936)CAG>TAG	p.Q312*		NM_001080460	NP_001073929	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	312	LRR 13.										0						GGACCTAAGCCAGAACCATCT	0.567													23	28					0	0	1	0	0
LRRC31	79782	broad.mit.edu	37	3	169572738	169572738	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:169572738C>T	uc003fgc.1	-	6	931	c.854G>A	c.(853-855)AGG>AAG	p.R285K	LRRC31_uc010hwp.1_Missense_Mutation_p.R229K	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	285	LRR 3.									ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			ATCTAATTTCCTCAGCTCACC	0.348													38	50					0	0	1	0	0
LRRC31	79782	broad.mit.edu	37	3	169574228	169574228	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:169574228A>G	uc003fgc.1	-	5	796	c.719T>C	c.(718-720)GTT>GCT	p.V240A	LRRC31_uc010hwp.1_Missense_Mutation_p.V184A	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	240	LRR 1.									ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			CAGACTGCCAACAATGTCTCT	0.378													19	103					0	0	1	0	0
NCEH1	57552	broad.mit.edu	37	3	172353837	172353837	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:172353837G>A	uc011bpx.1	-	4	736	c.598C>T	c.(598-600)CAT>TAT	p.H200Y	NCEH1_uc003fig.2_Missense_Mutation_p.H192Y|NCEH1_uc011bpw.1_Missense_Mutation_p.H27Y|NCEH1_uc011bpy.1_Missense_Mutation_p.H27Y	NM_001146276	NP_001139748	Q6PIU2	NCEH1_HUMAN	arylacetamide deacetylase-like 1 isoform a	160	Lumenal (Potential).				lipid catabolic process	endoplasmic reticulum|integral to membrane|microsome	carboxylesterase activity				0						ACAACATCATGAATTTGCTCA	0.393													77	99					0	0	1	0	0
CCDC39	339829	broad.mit.edu	37	3	180372715	180372715	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:180372715C>T	uc010hxe.2	-	7	880	c.765G>A	c.(763-765)ACG>ACA	p.T255T	CCDC39_uc003fkn.2_RNA	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	255	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			CTTTTTCTCTCGTTTCCTGCT	0.289													3	8					0	0	1	0	0
DCUN1D1	54165	broad.mit.edu	37	3	182683387	182683387	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:182683387C>T	uc003fld.1	-	2	207	c.158G>A	c.(157-159)CGA>CAA	p.R53Q	DCUN1D1_uc011bqn.1_5'UTR	NM_020640	NP_065691	Q96GG9	DCNL1_HUMAN	RP42 homolog	53						ubiquitin ligase complex	protein binding			ovary(1)	1	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;2.54e-44)|Epithelial(37;4.71e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			TACACTCTCTCGTATATAAAG	0.348													5	62					0	0	1	0	0
MAP3K13	9175	broad.mit.edu	37	3	185184628	185184628	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:185184628T>C	uc010hyf.2	+	11	1786	c.1520T>C	c.(1519-1521)GTG>GCG	p.V507A	MAP3K13_uc011brt.1_Missense_Mutation_p.V300A|MAP3K13_uc011bru.1_Missense_Mutation_p.V363A|MAP3K13_uc003fpi.2_Missense_Mutation_p.V507A|MAP3K13_uc010hyg.2_Missense_Mutation_p.V197A	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	507	Leucine-zipper 2.				activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			GAGCAAGCAGTGGAAAAGAAG	0.473													4	105					0	0	1	0	0
MAP3K13	9175	broad.mit.edu	37	3	185198317	185198317	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:185198317G>A	uc010hyf.2	+	14	3065	c.2799G>A	c.(2797-2799)GAG>GAA	p.E933E	MAP3K13_uc011brt.1_Silent_p.E726E|MAP3K13_uc011bru.1_Silent_p.E789E|MAP3K13_uc003fpi.2_Silent_p.E933E|MAP3K13_uc010hyg.2_Silent_p.E623E	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	933					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			GTGGCTATGAGGTGGGGGCTT	0.507													38	53					0	0	1	0	0
TMEM41A	90407	broad.mit.edu	37	3	185213024	185213024	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:185213024C>T	uc003fpj.2	-	3	449	c.353G>A	c.(352-354)TGC>TAC	p.C118Y	TMEM41A_uc003fpk.2_Intron|TMEM41A_uc003fpl.2_3'UTR	NM_080652	NP_542383	Q96HV5	TM41A_HUMAN	transmembrane protein 41A precursor	118	Helical; (Potential).					integral to membrane					0	all_cancers(143;7.78e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			CAGGTAGCAGCATGTGGCACC	0.517													21	107					0	0	1	0	0
LEPREL1	55214	broad.mit.edu	37	3	189713187	189713187	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:189713187G>A	uc011bsk.1	-	2	913	c.525C>T	c.(523-525)TTC>TTT	p.F175F	LEPREL1_uc003fsg.2_5'UTR	NM_018192	NP_060662	Q8IVL5	P3H2_HUMAN	leprecan-like 1 isoform a	175	TPR 2.				collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			breast(3)|ovary(1)	4	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	GGTTAGCCACGAAAAATGTGT	0.433													29	42					0	0	1	0	0
C3orf59	151963	broad.mit.edu	37	3	192516937	192516937	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:192516937C>T	uc011bsp.1	-	2	1035	c.714G>A	c.(712-714)GTG>GTA	p.V238V		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	238											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		TGAAAGATACCACAGGGACAA	0.478													15	27					0	0	1	0	0
GP5	2814	broad.mit.edu	37	3	194118881	194118881	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:194118881G>A	uc003ftv.1	-	2	162	c.131C>T	c.(130-132)TCC>TTC	p.S44F		NM_004488	NP_004479	P40197	GPV_HUMAN	glycoprotein V (platelet) precursor	44	LRRNT.|Extracellular (Potential).				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				skin(2)|breast(1)	3	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		GCCTAGCGCGGAGATGCGCGC	0.697													24	71					0	0	1	0	0
MFI2	4241	broad.mit.edu	37	3	196749882	196749883	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:196749882_196749883CC>TT	uc003fxk.3	-	5	702_703	c.589_590GG>AA	c.(589-591)GGG>AAG	p.G197K	MFI2_uc003fxl.3_Missense_Mutation_p.G197K|MFI2_uc011bua.1_Missense_Mutation_p.G170R	NM_005929	NP_005920	P08582	TRFM_HUMAN	melanoma-associated antigen p97 isoform 1	197	Transferrin-like 1.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding				0	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		GTCACACACCCCTTCCCCAGAG	0.653													63	104					0	0	1	0	0
DLG1	1739	broad.mit.edu	37	3	196921404	196921404	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:196921404G>A	uc003fxo.3	-	5	565	c.375C>T	c.(373-375)ATC>ATT	p.I125I	DLG1_uc011bud.1_5'UTR|DLG1_uc003fxn.3_Silent_p.I125I|DLG1_uc011bue.1_Silent_p.I125I|DLG1_uc010ial.2_Silent_p.I125I|DLG1_uc011buf.1_RNA|DLG1_uc003fxp.2_RNA|DLG1_uc010iam.1_Silent_p.I125I	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	125					actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		CTTCATTTGTGATTTGTGGGG	0.368													31	67					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348646	197348646	+	RNA	SNP	T	C	C	rs138265355	by1000genomes	TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr3:197348646T>C	uc011bug.1	-	4		c.445A>G			LOC220729_uc003fxw.2_RNA|LOC220729_uc003fxy.2_RNA|LOC220729_uc010iao.1_Intron					Homo sapiens cDNA FLJ60865 complete cds, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1).												0						TGGGCCTGCCTGCCCTTTCCA	0.532													6	180					0	0	1	0	0
ZNF721	170960	broad.mit.edu	37	4	436563	436563	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:436563T>C	uc003gag.2	-	3	2384	c.1693A>G	c.(1693-1695)ACC>GCC	p.T565A	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Missense_Mutation_p.T597A|ZNF721_uc010ibe.2_Missense_Mutation_p.T553A	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	565						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TGTCTAAAGGTTTTGCCACAT	0.418													4	137					0	0	1	0	0
PDE6B	5158	broad.mit.edu	37	4	654258	654258	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:654258G>A	uc003gap.2	+	12	1523	c.1470G>A	c.(1468-1470)AAG>AAA	p.K490K	PDE6B_uc003gao.3_Silent_p.K490K|PDE6B_uc011buy.1_Silent_p.K211K	NM_000283	NP_000274	P35913	PDE6B_HUMAN	phosphodiesterase 6B isoform 1	490					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0						TCCCACAGAAGGAGGAGCTGC	0.567													9	44					0	0	1	0	0
PDE6B	5158	broad.mit.edu	37	4	658005	658005	+	Silent	SNP	C	T	T	rs144847778		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:658005C>T	uc003gap.2	+	17	2177	c.2124C>T	c.(2122-2124)ATC>ATT	p.I708I	PDE6B_uc003gao.3_Silent_p.I708I|PDE6B_uc011buy.1_Silent_p.I429I|PDE6B_uc011buz.1_Silent_p.I140I	NM_000283	NP_000274	P35913	PDE6B_HUMAN	phosphodiesterase 6B isoform 1	708					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0						GGAAGGAGATCGTCATGTGAG	0.622													27	56					0	0	1	0	0
DGKQ	1609	broad.mit.edu	37	4	954932	954932	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:954932G>A	uc003gbw.2	-	22	2706	c.2632C>T	c.(2632-2634)CGA>TGA	p.R878*	DGKQ_uc010ibn.2_Nonsense_Mutation_p.R865*	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	878					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			AGCGTGACTCGGAAGTAGGAA	0.692													22	23					0	0	1	0	0
SLC26A1	10861	broad.mit.edu	37	4	985081	985081	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:985081C>T	uc003gcb.2	-	3	789	c.411G>A	c.(409-411)GTG>GTA	p.V137V	SLC26A1_uc003gbx.2_Silent_p.V137V|IDUA_uc003gby.2_Intron|IDUA_uc003gbz.2_Intron|IDUA_uc003gca.2_Intron|SLC26A1_uc003gcc.2_Silent_p.V137V	NM_213613	NP_998778	Q9H2B4	S26A1_HUMAN	solute carrier family 26, member 1 isoform a	137						integral to membrane|plasma membrane	secondary active sulfate transmembrane transporter activity			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GCTCCCGGTCCACCACCTGCC	0.647													57	37					0	0	1	0	0
NOP14	8602	broad.mit.edu	37	4	2943344	2943344	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:2943344G>A	uc003ggj.1	-	15	2236	c.2164C>T	c.(2164-2166)CAC>TAC	p.H722Y	C4orf10_uc003ggd.1_RNA|C4orf10_uc003gge.1_Intron|C4orf10_uc003ggg.1_RNA|C4orf10_uc003ggh.2_Intron|C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_Intron|NOP14_uc003ggk.3_Missense_Mutation_p.H722Y|NOP14_uc003ggl.2_Missense_Mutation_p.H722Y	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	722					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1						TCCGCCAGGTGATCCGTGAGG	0.672													8	17					0	0	1	0	0
EVC	2121	broad.mit.edu	37	4	5806560	5806560	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:5806560C>T	uc003gil.1	+	17	2737	c.2553C>T	c.(2551-2553)GTC>GTT	p.V851V	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Intron	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	851					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				CCCAGGCGGTCCACCAGAGGT	0.582													15	29					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6081970	6081970	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:6081970C>T	uc003giu.3	-	7	1447	c.1171G>A	c.(1171-1173)GAT>AAT	p.D391N	JAKMIP1_uc010idb.1_Missense_Mutation_p.D391N|JAKMIP1_uc010idc.1_Missense_Mutation_p.D226N|JAKMIP1_uc010idd.1_Missense_Mutation_p.D391N|JAKMIP1_uc011bwc.1_Missense_Mutation_p.D226N|JAKMIP1_uc003giv.3_Missense_Mutation_p.D391N|JAKMIP1_uc010ide.2_Missense_Mutation_p.D391N	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	391	Mediates interaction with TYK2 and GABBR1.|Potential.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						TCCTGCTCATCCCTCGTCAGG	0.592													8	33					0	0	1	0	0
SLC2A9	56606	broad.mit.edu	37	4	9909970	9909970	+	Splice_Site	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:9909970C>T	uc003gmc.2	-	8	1064	c.1003_splice	c.e8-1	p.I335_splice	SLC2A9_uc003gmd.2_Splice_Site_p.I306_splice	NM_020041	NP_064425	Q9NRM0	GTR9_HUMAN	solute carrier family 2, member 9 protein						glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			ovary(3)	3						AGAACCAAATCTGTAATTCAG	0.438													11	24					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20544117	20544117	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:20544117G>A	uc003gpr.1	+	21	2348	c.2144G>A	c.(2143-2145)GGA>GAA	p.G715E	SLIT2_uc003gps.1_Missense_Mutation_p.G707E	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	715					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						TGCGATTTAGGAAATGATGAC	0.408													129	86					0	0	1	0	0
GBA3	57733	broad.mit.edu	37	4	22749088	22749088	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:22749088C>T	uc003gqp.3	+	3	547	c.456C>T	c.(454-456)ACC>ACT	p.T152T	GBA3_uc010iep.2_Intron|GBA3_uc011bxo.1_Silent_p.T153T	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	152					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						GCTTCAGTACCTTTGGGGATC	0.423													42	22					0	0	1	0	0
GBA3	57733	broad.mit.edu	37	4	22749597	22749597	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:22749597G>A	uc003gqp.3	+	3	1056	c.965G>A	c.(964-966)GGA>GAA	p.G322E	GBA3_uc010iep.2_Intron|GBA3_uc011bxo.1_Missense_Mutation_p.G323E	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	322					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						AACAAGAAAGGAGAACTAGGT	0.383													4	9					0	0	1	0	0
CCDC149	91050	broad.mit.edu	37	4	24875320	24875320	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:24875320G>A	uc011bxr.1	-	4	391	c.247C>T	c.(247-249)CCT>TCT	p.P83S	CCDC149_uc003grc.2_Missense_Mutation_p.P83S|CCDC149_uc003grb.2_RNA|CCDC149_uc003grd.2_Missense_Mutation_p.P83S|CCDC149_uc003gre.2_Missense_Mutation_p.P28S	NM_173463	NP_775734	B4DZG3	B4DZG3_HUMAN	coiled-coil domain containing 149 isoform 1	83											0		Breast(46;0.173)				CTTTTTTCAGGAGGAAGTGAT	0.333													11	32					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36230906	36230906	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:36230906A>C	uc003gsq.1	-	2	541	c.203T>G	c.(202-204)TTG>TGG	p.L68W	ARAP2_uc003gsr.1_Missense_Mutation_p.L68W	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	68	SAM.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CATTTTTGACAAGATTATCTG	0.368													9	23					0	0	1	0	0
TLR10	81793	broad.mit.edu	37	4	38775153	38775153	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:38775153C>T	uc003gti.2	-	2	2438	c.2059G>A	c.(2059-2061)GAG>AAG	p.E687K	TLR10_uc003gtj.2_Missense_Mutation_p.E687K|TLR10_uc003gtk.2_Missense_Mutation_p.E687K	NM_030956	NP_112218	Q9BXR5	TLR10_HUMAN	toll-like receptor 10 precursor	687	TIR.|Cytoplasmic (Potential).				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			lung(1)|breast(1)	2						TAGCTTTTCTCAATGAAGCTT	0.388													64	35					0	0	1	0	0
KLB	152831	broad.mit.edu	37	4	39436032	39436032	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:39436032G>A	uc003gua.2	+	2	1125	c.1028G>A	c.(1027-1029)GGG>GAG	p.G343E	KLB_uc011byj.1_Missense_Mutation_p.G343E	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	343	Extracellular (Potential).|Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						TATCCAGAGGGGATGAGAAAG	0.453													31	53					0	0	1	0	0
APBB2	323	broad.mit.edu	37	4	40946981	40946981	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:40946981C>T	uc003gvl.2	-	7	1572	c.942G>A	c.(940-942)ACG>ACA	p.T314T	APBB2_uc010ifu.2_5'UTR|APBB2_uc003gvm.2_Silent_p.T314T|APBB2_uc003gvn.2_Silent_p.T315T|APBB2_uc011byt.1_Silent_p.T297T	NM_173075	NP_775098	Q92870	APBB2_HUMAN	amyloid beta A4 precursor protein-binding,	314	WW.				cell cycle arrest|intracellular signal transduction|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			ovary(2)|large_intestine(1)	3						CCCACTGAGTCGTTCCTGTTG	0.537													65	50					0	0	1	0	0
YIPF7	285525	broad.mit.edu	37	4	44626661	44626661	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:44626661G>A	uc010ifx.1	-	5	654	c.637C>T	c.(637-639)CCC>TCC	p.P213S		NM_182592	NP_872398	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	213	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane					0						ATGACCATGGGGAGCAGGCAG	0.542													13	10					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47746434	47746434	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:47746434C>T	uc003gxm.2	-	5	877	c.784G>A	c.(784-786)GAA>AAA	p.E262K	CORIN_uc011bzf.1_Missense_Mutation_p.E123K|CORIN_uc011bzg.1_Missense_Mutation_p.E195K|CORIN_uc011bzh.1_Missense_Mutation_p.E262K|CORIN_uc011bzi.1_Missense_Mutation_p.E262K|CORIN_uc003gxn.3_Missense_Mutation_p.E262K	NM_006587	NP_006578	Q9Y5Q5	CORIN_HUMAN	corin	262	Extracellular (Potential).				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			ovary(1)|central_nervous_system(1)	2						TTTCCGTTTTCCTGCTGAGGT	0.308													27	84					0	0	1	0	0
LRRC66	339977	broad.mit.edu	37	4	52861097	52861097	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:52861097A>C	uc003gzi.2	-	4	2104	c.2091T>G	c.(2089-2091)TGT>TGG	p.C697W		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	697						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						TCTCCAACTCACAGCAAGTGT	0.522													26	71					0	0	1	0	0
UGT2B11	10720	broad.mit.edu	37	4	70071286	70071286	+	Splice_Site	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:70071286C>T	uc003heh.2	-	4	1012	c.1003_splice	c.e4-1	p.V335_splice	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,						estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						TCCACAGAACCTGTTACAGTA	0.398													5	19					0	0	1	0	0
MUC7	4589	broad.mit.edu	37	4	71347138	71347138	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:71347138C>T	uc011cat.1	+	4	965	c.677C>T	c.(676-678)CCA>CTA	p.P226L	MUC7_uc011cau.1_Missense_Mutation_p.P226L|MUC7_uc003hfj.2_Missense_Mutation_p.P226L|uc011cav.1_Intron	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	226	3.|Thr-rich.					extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			CCAGCTCCACCATCTTCCTCA	0.582													5	280					0	0	1	0	0
AMBN	258	broad.mit.edu	37	4	71472162	71472162	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:71472162C>T	uc003hfl.2	+	13	1134	c.1059C>T	c.(1057-1059)CTC>CTT	p.L353L		NM_016519	NP_057603	Q9NP70	AMBN_HUMAN	ameloblastin precursor	353					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			ovary(3)|skin(1)	4			Lung(101;0.235)			ACGCAGGGCTCCTTGCTCTCC	0.592													12	15					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79420961	79420961	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:79420961A>C	uc003hlb.2	+	61	9642	c.9202A>C	c.(9202-9204)ATC>CTC	p.I3068L	FRAS1_uc003hlc.1_Missense_Mutation_p.I70L	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3063	Calx-beta 5.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CATCAAGGTGATCCGCAGAGG	0.547													76	52					0	0	1	0	0
BMP3	651	broad.mit.edu	37	4	81967395	81967395	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:81967395G>A	uc003hmg.3	+	2	1140	c.820G>A	c.(820-822)GAT>AAT	p.D274N		NM_001201	NP_001192	P12645	BMP3_HUMAN	bone morphogenetic protein 3 preproprotein	274					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(4)|central_nervous_system(1)	5						TCCCAAATGGGATAGCCACAT	0.517													26	16					0	0	1	0	0
ENOPH1	58478	broad.mit.edu	37	4	83375960	83375960	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:83375960G>A	uc003hmv.2	+	4	732	c.475G>A	c.(475-477)GCA>ACA	p.A159T	ENOPH1_uc003hmw.2_Missense_Mutation_p.A71T|ENOPH1_uc003hmx.2_Missense_Mutation_p.A13T	NM_021204	NP_067027	Q9UHY7	ENOPH_HUMAN	enolase-phosphatase 1	159					L-methionine salvage from methylthioadenosine	cytoplasm|nucleus	2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity|2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity|acireductone synthase activity|magnesium ion binding|phosphoglycolate phosphatase activity				0						GAGTGTGGAGGCACAGAAACT	0.443													128	80					0	0	1	0	0
SEC31A	22872	broad.mit.edu	37	4	83800043	83800043	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:83800043G>A	uc003hnf.2	-	4	406	c.242C>T	c.(241-243)TCC>TTC	p.S81F	SEC31A_uc011ccl.1_Missense_Mutation_p.S81F|SEC31A_uc003hnl.2_Missense_Mutation_p.S81F|SEC31A_uc003hng.2_Missense_Mutation_p.S81F|SEC31A_uc003hnh.2_Missense_Mutation_p.S81F|SEC31A_uc003hni.2_Missense_Mutation_p.S81F|SEC31A_uc003hnj.2_Missense_Mutation_p.S81F|SEC31A_uc011ccm.1_Missense_Mutation_p.S76F|SEC31A_uc011ccn.1_Missense_Mutation_p.S81F|SEC31A_uc003hnk.2_Missense_Mutation_p.S81F|SEC31A_uc003hnm.2_Missense_Mutation_p.S81F|SEC31A_uc003hnn.1_Missense_Mutation_p.S81F|SEC31A_uc003hno.2_Missense_Mutation_p.S81F	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	81	WD 1.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				ATCTCCTTTGGAATCCATTTT	0.338													13	37					0	0	1	0	0
MRPS18C	51023	broad.mit.edu	37	4	84377277	84377277	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:84377277T>C	uc003hor.3	+	1	160	c.47T>C	c.(46-48)TTG>TCG	p.L16S	HELQ_uc003hom.2_5'Flank|HELQ_uc010ikb.2_5'Flank|HELQ_uc003hol.3_5'Flank|HELQ_uc010ikc.2_5'Flank|HELQ_uc003hon.1_5'Flank|HELQ_uc003hoo.1_5'Flank|HELQ_uc003hop.1_5'Flank|HELQ_uc003hoq.1_5'Flank|MRPS18C_uc011ccu.1_Missense_Mutation_p.L16S	NM_016067	NP_057151	Q9Y3D5	RT18C_HUMAN	mitochondrial ribosomal protein S18C precursor	16					translation	mitochondrial small ribosomal subunit	structural constituent of ribosome				0		Hepatocellular(203;0.114)				AGGAAGAAGTTGACACACTTG	0.527													36	216					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94159576	94159576	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:94159576C>T	uc011cdt.1	+	8	1438	c.1180C>T	c.(1180-1182)CCC>TCC	p.P394S	GRID2_uc011cdu.1_Missense_Mutation_p.P299S|GRID2_uc010ikz.1_Missense_Mutation_p.P75S	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	394	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TGGAGGCAATCCCAATGTCCA	0.403													31	27					0	0	1	0	0
NFKB1	4790	broad.mit.edu	37	4	103517389	103517389	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:103517389C>T	uc011ceq.1	+	14	1859	c.1392C>T	c.(1390-1392)ACC>ACT	p.T464T	NFKB1_uc011cep.1_Silent_p.T465T|NFKB1_uc011cer.1_Silent_p.T284T	NM_003998	NP_003989	P19838	NFKB1_HUMAN	nuclear factor kappa-B, subunit 1 isoform 1	464	Interaction with CFLAR.				anti-apoptosis|apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of calcidiol 1-monooxygenase activity|nerve growth factor receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter	cytosol|I-kappaB/NF-kappaB complex|mitochondrion|nucleoplasm	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|breast(2)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.59e-08)	Dexamethasone(DB01234)|Pranlukast(DB01411)|Thalidomide(DB01041)	TTATTGAAACCACAGAGCAAG	0.458													27	25					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115997860	115997860	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:115997860G>A	uc003ibu.2	-	2	1012	c.333C>T	c.(331-333)GCC>GCT	p.A111A	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	111	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		CCTTTCCAGGGGCAATAACCA	0.403													13	31					0	0	1	0	0
PRSS12	8492	broad.mit.edu	37	4	119239661	119239661	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:119239661G>A	uc003ica.1	-	5	1069	c.1022C>T	c.(1021-1023)CCA>CTA	p.P341L		NM_003619	NP_003610	P56730	NETR_HUMAN	neurotrypsin precursor	341	SRCR 2.					membrane	scavenger receptor activity			skin(1)	1						CAACATAACTGGGCCAGACCC	0.448													17	34					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119952529	119952529	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:119952529G>A	uc003icm.3	+	4	2795	c.2599G>A	c.(2599-2601)GGA>AGA	p.G867R	SYNPO2_uc010ina.2_Missense_Mutation_p.G867R|SYNPO2_uc010inb.2_Missense_Mutation_p.G867R|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Missense_Mutation_p.G795R	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	867						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						TGAGCTTCCAGGAATGAGTGG	0.527													47	123					0	0	1	0	0
QRFPR	84109	broad.mit.edu	37	4	122301782	122301782	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:122301782G>A	uc010inj.1	-	1	400	c.21C>T	c.(19-21)ACC>ACT	p.T7T	QRFPR_uc010ink.1_RNA|QRFPR_uc003ids.2_Silent_p.T7T|QRFPR_uc010inl.1_Silent_p.T7T	NM_198179	NP_937822	Q96P65	QRFPR_HUMAN	G protein-coupled receptor 103	7	Extracellular (Potential).					plasma membrane	neuropeptide Y receptor activity				0						ACTGCTCCGGGGTAATGTTAA	0.682													4	14					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123130369	123130369	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:123130369C>T	uc003ieh.2	+	16	1853	c.1808C>T	c.(1807-1809)TCT>TTT	p.S603F	KIAA1109_uc003iei.1_Missense_Mutation_p.S357F|KIAA1109_uc010ins.1_Intron|KIAA1109_uc003iej.1_5'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	603					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AGTAAATATTCTTTATTTATG	0.318													7	25					0	0	1	0	0
TIGD4	201798	broad.mit.edu	37	4	153691349	153691349	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:153691349G>A	uc003imy.2	-	2	1590	c.808C>T	c.(808-810)CGA>TGA	p.R270*		NM_145720	NP_663772	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	270	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			ovary(1)	1	all_hematologic(180;0.093)					TCAAGCTTTCGCATCCATTGT	0.403													33	87					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155156591	155156591	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:155156591C>T	uc003inw.2	-	25	7848	c.7848G>A	c.(7846-7848)TGG>TGA	p.W2616*		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2616					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TTAAACTCAACCATTCCGGAG	0.488													25	21					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155507613	155507613	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:155507613G>A	uc003iod.1	-	5	1026	c.968C>T	c.(967-969)CCT>CTT	p.P323L	FGA_uc003ioe.1_Missense_Mutation_p.P323L|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	323	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	AGAGCTCCCAGGTTTCCAGGT	0.567													19	41					0	0	1	0	0
GRIA2	2891	broad.mit.edu	37	4	158257886	158257886	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:158257886G>A	uc003ipm.3	+	11	2290	c.1831G>A	c.(1831-1833)GAT>AAT	p.D611N	GRIA2_uc011cit.1_Missense_Mutation_p.D564N|GRIA2_uc003ipl.3_Missense_Mutation_p.D611N|GRIA2_uc003ipk.3_Missense_Mutation_p.D564N|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	611	Cytoplasmic (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	GCAAGGATGCGATATTTCGCC	0.398													16	72					0	0	1	0	0
RXFP1	59350	broad.mit.edu	37	4	159568321	159568321	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:159568321G>A	uc003ipz.2	+	16	1806	c.1724G>A	c.(1723-1725)GGA>GAA	p.G575E	RXFP1_uc011cja.1_Missense_Mutation_p.G470E|RXFP1_uc010iqo.2_Missense_Mutation_p.G527E|RXFP1_uc011cjb.1_Missense_Mutation_p.G473E|RXFP1_uc010iqk.2_Missense_Mutation_p.G443E|RXFP1_uc011cjc.1_Missense_Mutation_p.G494E|RXFP1_uc011cjd.1_Missense_Mutation_p.G494E|RXFP1_uc010iql.2_Missense_Mutation_p.G419E|RXFP1_uc011cje.1_Missense_Mutation_p.G602E|RXFP1_uc010iqm.2_Missense_Mutation_p.G542E|RXFP1_uc011cjf.1_Missense_Mutation_p.G444E|RXFP1_uc010iqn.2_Missense_Mutation_p.G520E	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	575	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		GAAAGTATTGGAGCCCAGATT	0.333													8	38					0	0	1	0	0
NPY5R	4889	broad.mit.edu	37	4	164271684	164271684	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:164271684G>A	uc003iqn.2	+	4	441	c.259G>A	c.(259-261)GAT>AAT	p.D87N		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	87	Helical; Name=2; (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				GGCCTTTTCTGATATCTTGGT	0.413													152	100					0	0	1	0	0
ASB5	140458	broad.mit.edu	37	4	177143511	177143511	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:177143511C>T	uc003iuq.1	-	3	353	c.337G>A	c.(337-339)GGA>AGA	p.G113R	ASB5_uc003iup.1_Missense_Mutation_p.G60R	NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein	113	ANK 2.				intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		ACGTGATCTCCAAGGCAGGCT	0.423													65	40					0	0	1	0	0
ODZ3	55714	broad.mit.edu	37	4	183650253	183650253	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:183650253A>C	uc003ivd.1	+	13	2541	c.2504A>C	c.(2503-2505)AAA>ACA	p.K835T	ODZ3_uc003ive.1_Missense_Mutation_p.K241T	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	835	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		CAAGCTGCCAAATCCTTTTAT	0.448													30	21					0	0	1	0	0
ODZ3	55714	broad.mit.edu	37	4	183710262	183710262	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:183710262T>A	uc003ivd.1	+	24	5358	c.5321T>A	c.(5320-5322)CTC>CAC	p.L1774H		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1774	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		GGCAGAAACCTCCTTTCAGTT	0.418													11	5					0	0	1	0	0
ING2	3622	broad.mit.edu	37	4	184432007	184432007	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:184432007C>T	uc003ivs.1	+	2	874	c.745C>T	c.(745-747)CCA>TCA	p.P249S	ING2_uc011ckk.1_Missense_Mutation_p.P209S	NM_001564	NP_001555	Q9H160	ING2_HUMAN	inhibitor of growth family, member 2	249	PHD-type.				chromatin modification|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of growth|signal transduction|transcription, DNA-dependent	CCAAT-binding factor complex|Sin3 complex	chromatin binding|DNA binding|protein complex binding|zinc ion binding			ovary(1)	1		all_lung(41;5.16e-14)|Lung NSC(41;1.33e-13)|Colorectal(36;0.00139)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|all_hematologic(60;0.0207)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		TACCTATAAACCAAAGGGGAA	0.383													17	39					0	0	1	0	0
SLC9A3	6550	broad.mit.edu	37	5	484712	484712	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:484712G>A	uc003jbe.2	-	5	967	c.855C>T	c.(853-855)ATC>ATT	p.I285I	SLC9A3_uc011clx.1_Silent_p.I285I	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	285	Cytoplasmic (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			AGCCGGGCTCGATGATACGCA	0.622													6	63					0	0	1	0	0
SDHAP3	728609	broad.mit.edu	37	5	1576333	1576333	+	RNA	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:1576333C>T	uc011cmd.1	-	2		c.396G>A			SDHAP3_uc011cme.1_RNA					Homo sapiens cDNA FLJ58919 complete cds, moderately similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial precursor (EC1.3.5.1).												0						GTGACTCCTTCCGCGCCTCTG	0.642													23	4					0	0	1	0	0
MTRR	4552	broad.mit.edu	37	5	7895940	7895940	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:7895940C>T	uc003jed.2	+	12	1762	c.1732C>T	c.(1732-1734)CCG>TCG	p.P578S	MTRR_uc003jee.3_Missense_Mutation_p.P551S|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	578					methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	CGGCATAGCCCCGTTTATTGG	0.408													81	13					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13708340	13708340	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:13708340G>A	uc003jfd.2	-	76	13272	c.13230C>T	c.(13228-13230)ACC>ACT	p.T4410T	DNAH5_uc003jfc.2_Silent_p.T578T	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4410	Potential.				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GCTCAGTGAGGGTGCTGCGGA	0.483									Kartagener_syndrome				21	167					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13762910	13762910	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:13762910C>T	uc003jfd.2	-	60	10244	c.10202G>A	c.(10201-10203)GGA>GAA	p.G3401E	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3401	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AGCTACATTTCCACATACGCG	0.408									Kartagener_syndrome				5	45					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13776634	13776634	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:13776634C>T	uc003jfd.2	-	55	9329	c.9287G>A	c.(9286-9288)CGA>CAA	p.R3096Q		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3096	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AGCTCTGTTTCGAAATTTCTC	0.478									Kartagener_syndrome				4	33					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13824344	13824344	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:13824344G>A	uc003jfd.2	-	39	6585	c.6543C>T	c.(6541-6543)GTC>GTT	p.V2181V		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2181					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GTACACGCATGACAATCGTGG	0.443									Kartagener_syndrome				46	10					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13883157	13883157	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:13883157G>A	uc003jfd.2	-	20	3072	c.3030C>T	c.(3028-3030)TTC>TTT	p.F1010F		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1010	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CGCTTGCCCGGAAAATGGGCA	0.458									Kartagener_syndrome				5	97					0	0	1	0	0
UGT3A1	133688	broad.mit.edu	37	5	35957468	35957469	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:35957468_35957469GG>AA	uc003jjv.1	-	5	1053_1054	c.896_897CC>TT	c.(895-897)GCC>GTT	p.A299V	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Missense_Mutation_p.A299V|UGT3A1_uc011cor.1_Missense_Mutation_p.A265V	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	299	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGGAGCCAAAGGCCACAAGGAC	0.49													32	10					0	0	1	0	0
LMBRD2	92255	broad.mit.edu	37	5	36143317	36143317	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:36143317G>A	uc003jkb.1	-	2	550	c.135C>T	c.(133-135)TGC>TGT	p.C45C		NM_001007527	NP_001007528	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	45	Helical; (Potential).					integral to membrane					0	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CAATAAGAAAGCAGAGATACC	0.343													25	6					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38418314	38418314	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:38418314G>A	uc003jlc.1	+	12	1965	c.1641G>A	c.(1639-1641)ATG>ATA	p.M547I	EGFLAM_uc003jlb.1_Missense_Mutation_p.M547I|EGFLAM_uc003jle.1_Missense_Mutation_p.M313I|EGFLAM_uc003jlf.1_Intron	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	547	Laminin G-like 1.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					GAATTGACATGAGGCCCTGGC	0.562													30	10					0	0	1	0	0
LIFR	3977	broad.mit.edu	37	5	38481998	38481998	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:38481998C>T	uc010ive.1	-	20	3325	c.2993G>A	c.(2992-2994)GGG>GAG	p.G998E	LIFR_uc003jli.2_Missense_Mutation_p.G998E	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	998	Cytoplasmic (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					ATAGCCTGCCCCTCCTACAGG	0.458			T	PLAG1	salivary adenoma								32	42					0	0	1	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41064601	41064601	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:41064601C>T	uc003jmj.3	-	5	923	c.433G>A	c.(433-435)GAA>AAA	p.E145K		NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	145							binding			ovary(6)|central_nervous_system(2)	8						TTCATCCTTTCATCCTCGGCC	0.463													22	6					0	0	1	0	0
SEPP1	6414	broad.mit.edu	37	5	42808345	42808345	+	RNA	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:42808345T>C	uc011cps.1	-	3		c.299A>G			SEPP1_uc011cpt.1_RNA|SEPP1_uc011cpu.1_RNA|SEPP1_uc011cpv.1_RNA|SEPP1_uc003jna.2_RNA			P49908	SEPP1_HUMAN	Homo sapiens cDNA FLJ37321 fis, clone BRAMY2018122.						response to oxidative stress	extracellular region	selenium binding				0						GATCTTGATCTCTTATGCTCC	0.522													10	32					0	0	1	0	0
MGC42105	167359	broad.mit.edu	37	5	43280221	43280221	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:43280221C>T	uc003jno.2	+	4	1582	c.701C>T	c.(700-702)CCT>CTT	p.P234L		NM_153361	NP_699192	Q8IY84	NIM1_HUMAN	serine/threonine-protein kinase NIM1	234	Protein kinase.						ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|stomach(1)|large_intestine(1)|breast(1)	9						TGTGGGTCTCCTCCCTACGCT	0.483													34	55					0	0	1	0	0
FGF10	2255	broad.mit.edu	37	5	44310583	44310584	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:44310583_44310584GG>AA	uc003jog.1	-	2	374_375	c.374_375CC>TT	c.(373-375)GCC>GTT	p.A125V		NM_004465	NP_004456	O15520	FGF10_HUMAN	fibroblast growth factor 10 precursor	125					actin cytoskeleton reorganization|activation of MAPK activity|bud outgrowth involved in lung branching|ERK1 and ERK2 cascade|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|insulin receptor signaling pathway|lacrimal gland development|lung saccule development|mesonephros development|negative regulation of cell cycle arrest|positive regulation of ATPase activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of DNA repair|positive regulation of DNA replication|positive regulation of epithelial cell migration|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of ERK1 and ERK2 cascade|positive regulation of hair follicle cell proliferation|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of lymphocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of urothelial cell proliferation|protein localization at cell surface|radial glial cell differentiation|regulation of saliva secretion|response to protein stimulus|secretion by lung epithelial cell involved in lung growth|tear secretion|thymus development|urothelial cell proliferation	cell surface|extracellular space|nucleus|plasma membrane	chemoattractant activity|growth factor activity|heparin binding|type 2 fibroblast growth factor receptor binding			lung(3)	3	Lung NSC(6;1.12e-06)					TGCTGTTAATGGCTTTGACGGC	0.351													5	2					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45262173	45262173	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:45262173G>A	uc003jok.2	-	8	2548	c.2523C>T	c.(2521-2523)CTC>CTT	p.L841L		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	841	Cytoplasmic (Potential).			L -> F (in Ref. 2; AAC39759).		integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TCTGTCGGAAGAGGGTGACGC	0.667													6	41					0	0	1	0	0
IL6ST	3572	broad.mit.edu	37	5	55253047	55253047	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:55253047A>C	uc003jqq.2	-	9	1301	c.1046T>G	c.(1045-1047)CTC>CGC	p.L349R	IL6ST_uc010iwb.2_Missense_Mutation_p.L349R|IL6ST_uc010iwc.2_Intron|IL6ST_uc010iwd.2_Intron|IL6ST_uc011cqk.1_Missense_Mutation_p.L60R|IL6ST_uc003jqr.2_Intron	NM_002184	NP_002175	P40189	IL6RB_HUMAN	interleukin 6 signal transducer isoform 1	349	Extracellular (Potential).|Fibronectin type-III 3.				interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity			large_intestine(1)|ovary(1)	2		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)				CTTCCACACGAGTTGTACAGT	0.239			O		hepatocellular ca								45	11					0	0	1	0	0
KIF2A	3796	broad.mit.edu	37	5	61673497	61673497	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:61673497G>A	uc003jsy.3	+	18	2118	c.1807G>A	c.(1807-1809)GTC>ATC	p.V603I	KIF2A_uc003jsz.3_Missense_Mutation_p.V641I|KIF2A_uc010iwp.2_Missense_Mutation_p.V584I|KIF2A_uc003jsx.3_Missense_Mutation_p.V583I|KIF2A_uc010iwq.2_Missense_Mutation_p.V406I	NM_004520	NP_004511	O00139	KIF2A_HUMAN	kinesin heavy chain member 2 isoform 1	603					blood coagulation|cell differentiation|cell division|microtubule-based movement|mitotic prometaphase|mitotic spindle organization|nervous system development	centrosome|cytosol|microtubule|spindle pole	ATP binding|microtubule motor activity|protein binding				0		Lung NSC(810;8.94e-06)|Prostate(74;0.0132)|Ovarian(174;0.051)|Breast(144;0.077)		Lung(70;0.14)		GGAAGAAGAAGTCTCTCCACA	0.284													6	1					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66461119	66461119	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:66461119C>G	uc003jut.1	+	28	5613	c.5545C>G	c.(5545-5547)CCG>GCG	p.P1849A	MAST4_uc003juw.2_Missense_Mutation_p.P1777A|MAST4_uc003jux.2_5'Flank	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	2041						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AGCATGGGCGCCGGGTGGGAA	0.557													9	11					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79033568	79033568	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:79033568G>A	uc003kgc.2	+	2	9052	c.8980G>A	c.(8980-8982)GAT>AAT	p.D2994N		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2994						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		ACTCCCTGATGATAGTGAAAC	0.323													13	1					0	0	1	0	0
THBS4	7060	broad.mit.edu	37	5	79354082	79354082	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:79354082C>T	uc003kgh.2	+	5	917	c.594C>T	c.(592-594)GCC>GCT	p.A198A		NM_003248	NP_003239	P35443	TSP4_HUMAN	thrombospondin 4 precursor	198					endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity				0		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		TCCAGGTGGCCAGCCTGCAAG	0.527													8	3					0	0	1	0	0
ACOT12	134526	broad.mit.edu	37	5	80626239	80626239	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:80626239C>A	uc003khl.3	-	15	1697	c.1642G>T	c.(1642-1644)GAT>TAT	p.D548Y	RNU5E_uc011cto.1_Intron	NM_130767	NP_570123	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	548	START.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(1)|kidney(1)	2		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		AACCCATCATCAGGAGGATTC	0.398													57	4					1.77355e-41	1.82329e-41	1	1	0
HAPLN1	1404	broad.mit.edu	37	5	82940460	82940460	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:82940460C>T	uc003kim.2	-	3	568	c.497G>A	c.(496-498)CGA>CAA	p.R166Q	HAPLN1_uc003kin.2_Missense_Mutation_p.R166Q	NM_001884	NP_001875	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	166	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			large_intestine(3)|ovary(1)|skin(1)	5		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		GCGCCCCAGTCGTGGAAAGTA	0.537													23	6					0	0	1	0	0
ANKRD32	84250	broad.mit.edu	37	5	94027898	94027899	+	Missense_Mutation	DNP	CC	GT	GT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:94027898_94027899CC>GT	uc003kkr.3	+	20	2712_2713	c.2632_2633CC>GT	c.(2632-2634)CCT>GTT	p.P878V	ANKRD32_uc003kks.2_Missense_Mutation_p.P242V	NM_032290	NP_115666	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32	878	ANK 3.									ovary(2)	2		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)		CGGGGTGACTCCTTTGCATGAT	0.446													19	24					0	0	1	0	0
EPB41L4A	64097	broad.mit.edu	37	5	111530276	111530276	+	Silent	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:111530276T>C	uc003kpv.1	-	17	1765	c.1491A>G	c.(1489-1491)AAA>AAG	p.K497K	EPB41L4A_uc003kpp.1_Silent_p.K124K	NM_022140	NP_071423	Q9HCS5	E41LA_HUMAN	erythrocyte protein band 4.1-like 4	497						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		TGTTTCTCTTTTTCCGGTATT	0.378													14	14					0	0	1	0	0
ALDH7A1	501	broad.mit.edu	37	5	125887819	125887819	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:125887819C>T	uc003ktx.2	-	14	1403	c.1211G>A	c.(1210-1212)CGC>CAC	p.R404H	ALDH7A1_uc003ktv.2_Missense_Mutation_p.R25H|ALDH7A1_uc003kty.2_RNA|ALDH7A1_uc011cxa.1_Missense_Mutation_p.R367H	NM_001182	NP_001173	P49419	AL7A1_HUMAN	aldehyde dehydrogenase 7 family, member A1	404					cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound	cytosol|mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity|betaine-aldehyde dehydrogenase activity|L-aminoadipate-semialdehyde dehydrogenase activity			kidney(2)|ovary(1)	3		all_cancers(142;0.24)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0417)|OV - Ovarian serous cystadenocarcinoma(64;0.068)|all cancers(49;0.109)	NADH(DB00157)|Pyridoxine(DB00165)	ATTTCCAGGGCGATCCATAAC	0.398													7	14					0	0	1	0	0
SLC27A6	28965	broad.mit.edu	37	5	128359348	128359348	+	Silent	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:128359348T>C	uc003kuy.2	+	7	1596	c.1200T>C	c.(1198-1200)TTT>TTC	p.F400F	SLC27A6_uc003kuz.2_Silent_p.F400F	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	400					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		AGTATGACTTTCAGAAAGATG	0.323													8	8					0	0	1	0	0
IL4	3565	broad.mit.edu	37	5	132018195	132018195	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:132018195G>A	uc003kxk.1	+	4	748	c.378G>A	c.(376-378)AAG>AAA	p.K126K	IL4_uc003kxl.1_Silent_p.K110K	NM_000589	NP_000580	P05112	IL4_HUMAN	interleukin 4 isoform 1 precursor	126					B cell differentiation|cellular defense response|chemotaxis|cholesterol metabolic process|connective tissue growth factor biosynthetic process|negative regulation of apoptosis|negative regulation of osteoclast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of interleukin-13 production|positive regulation of isotype switching to IgE isotypes|positive regulation of isotype switching to IgG isotypes|positive regulation of MHC class II biosynthetic process|positive regulation of T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|T-helper 2 cell cytokine production	extracellular space	cytokine activity|growth factor activity|interleukin-4 receptor binding				0		all_cancers(142;2.81e-05)|all_lung(232;1.47e-05)|Lung NSC(810;2.31e-05)|all_neural(839;0.0459)|Ovarian(839;0.0481)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	GBM - Glioblastoma multiforme(465;0.00245)		GTCCTGTGAAGGAAGCCAACC	0.398													37	8					0	0	1	0	0
KDM3B	51780	broad.mit.edu	37	5	137756403	137756403	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:137756403T>G	uc003lcy.1	+	15	3924	c.3724T>G	c.(3724-3726)TCC>GCC	p.S1242A	KDM3B_uc010jew.1_Missense_Mutation_p.S898A|KDM3B_uc011cys.1_Missense_Mutation_p.S274A	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	1242					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						AGAAGCAGGGTCCCTGAGGTC	0.458													53	10					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140165896	140165896	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:140165896G>A	uc003lhb.2	+	1	21	c.21G>A	c.(19-21)GGG>GGA	p.G7G	PCDHA1_uc003lha.2_Silent_p.G7G|PCDHA1_uc003lgz.2_Silent_p.G7G	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	7					homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTAGGAGAGGGGGCCTGGGAG	0.502													80	12					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188633	140188633	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:140188633C>T	uc003lhi.2	+	1	1962	c.1861C>T	c.(1861-1863)CCG>TCG	p.P621S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.P621S|PCDHA4_uc011daa.1_Missense_Mutation_p.P621S	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	621	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGCGCATCCCGTTCCGCGT	0.672													111	20					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140228279	140228279	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:140228279G>A	uc003lhu.2	+	1	923	c.199G>A	c.(199-201)GAT>AAT	p.D67N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.D67N	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	67	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTCCAGTTGGATTCCAAAGG	0.642													145	23					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554378	140554378	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:140554378C>T	uc003lit.2	+	1	2136	c.1962C>T	c.(1960-1962)GCC>GCT	p.A654A		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	654	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCGCTCGGCCACCGCCACGC	0.706													51	7					0	0	1	0	0
PCDHB9	56127	broad.mit.edu	37	5	140568937	140568937	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:140568937G>A	uc003liw.1	+	3	2046	c.2046G>A	c.(2044-2046)CAG>CAA	p.Q682Q		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	682	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCAGGCCCAGGCCGACTTGC	0.701													114	157					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140588665	140588665	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:140588665G>A	uc003liz.2	+	1	375	c.186G>A	c.(184-186)CGG>CGA	p.R62R	PCDHB12_uc011dak.1_Intron	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	62	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGTCTTCGCGGGGGGCTCGGG	0.507													71	14					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140712259	140712259	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:140712259G>A	uc003lji.1	+	1	2008	c.2008G>A	c.(2008-2010)GAC>AAC	p.D670N	PCDHGA1_uc011dan.1_Missense_Mutation_p.D670N	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	670	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGGATCTCCGACATCCTGGC	0.697													99	15					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140730737	140730737	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:140730737G>A	uc003ljo.1	+	1	910	c.910G>A	c.(910-912)GAT>AAT	p.D304N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Missense_Mutation_p.D304N	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	304	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCACATTGGATTTTGAAGA	0.413													85	7					0	0	1	0	0
FGF1	2246	broad.mit.edu	37	5	141993609	141993609	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:141993609G>A	uc003lmm.2	-	2	164	c.84C>T	c.(82-84)CTC>CTT	p.L28L	FGF1_uc011dbi.1_Silent_p.L28L|FGF1_uc003lmn.3_Silent_p.L28L|FGF1_uc003lmp.3_Silent_p.L28L|FGF1_uc003lmq.2_Silent_p.L28L|FGF1_uc010jgj.2_Silent_p.L28L|FGF1_uc003lmr.2_Silent_p.L28L|FGF1_uc003lms.3_Silent_p.L28L	NM_001144892	NP_001138364	P05230	FGF1_HUMAN	fibroblast growth factor 1 (acidic) isoform 1	28					angiogenesis|cellular response to heat|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cell migration|positive regulation of cholesterol biosynthetic process|positive regulation of intracellular protein kinase cascade|positive regulation of transcription from RNA polymerase II promoter	cell cortex|cytosol|extracellular space	fibroblast growth factor receptor binding|growth factor activity|heparin binding|S100 alpha binding				0		all_neural(839;0.0416)|Ovarian(839;0.0955)|all_hematologic(541;0.1)|Prostate(461;0.157)|Lung NSC(810;0.21)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00032)	Pentosan Polysulfate(DB00686)	TACAGTAGAGGAGTTTGGGCT	0.557													33	11					0	0	1	0	0
KCTD16	57528	broad.mit.edu	37	5	143853322	143853322	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:143853322C>T	uc003lnm.1	+	4	1561	c.932C>T	c.(931-933)TCC>TTC	p.S311F	KCTD16_uc003lnn.1_Missense_Mutation_p.S311F	NM_020768	NP_065819	Q68DU8	KCD16_HUMAN	potassium channel tetramerisation domain	311						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(2)|ovary(1)|skin(1)	4		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			AATGACCTCTCCACATCTAGC	0.582													54	9					0	0	1	0	0
GM2A	2760	broad.mit.edu	37	5	150646406	150646406	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:150646406C>T	uc003ltr.3	+	3	523	c.358C>T	c.(358-360)CCT>TCT	p.P120S	GM2A_uc011dcs.1_RNA|GM2A_uc011dcr.1_Missense_Mutation_p.P120S|GM2A_uc003ltt.1_Missense_Mutation_p.P52S|GM2A_uc003ltu.1_5'Flank	NM_000405	NP_000396	P17900	SAP3_HUMAN	GM2 ganglioside activator precursor	120						lysosome|nucleolus	sphingolipid activator protein activity				0		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CATGTTAATTCCTACTGGGGA	0.532													60	15					0	0	1	0	0
GALNT10	55568	broad.mit.edu	37	5	153765888	153765888	+	Silent	SNP	C	A	A	rs146278879		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:153765888C>A	uc003lvh.2	+	7	1086	c.954C>A	c.(952-954)GCC>GCA	p.A318A	GALNT10_uc003lvg.1_Silent_p.A318A|GALNT10_uc010jic.2_RNA|GALNT10_uc010jid.2_Silent_p.A159A	NM_198321	NP_938080	Q86SR1	GLT10_HUMAN	GalNAc transferase 10 isoform a	318	Catalytic subdomain B.|Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			CCGTGATGGCCGGTGGACTGT	0.572													164	19					2.6979e-105	2.78589e-105	1	1	0
ODZ2	57451	broad.mit.edu	37	5	167420156	167420156	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:167420156C>T	uc010jjd.2	+	5	1155	c.1155C>T	c.(1153-1155)CTC>CTT	p.L385L	ODZ2_uc003lzq.2_Silent_p.L264L|ODZ2_uc003lzr.3_Silent_p.L194L	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CCGCGGCCCTCCTCTTGGCTA	0.537													18	35					0	0	1	0	0
CCDC99	54908	broad.mit.edu	37	5	169021206	169021206	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:169021206C>T	uc003mae.3	+	5	868	c.589C>T	c.(589-591)CTT>TTT	p.L197F	CCDC99_uc010jjj.2_Missense_Mutation_p.L126F|CCDC99_uc011deq.1_Missense_Mutation_p.L14F|CCDC99_uc010jjk.2_Intron	NM_017785	NP_060255	Q96EA4	SPDLY_HUMAN	coiled-coil domain containing 99	197	Potential.				cell division|establishment of mitotic spindle orientation|mitotic metaphase plate congression|mitotic prometaphase|protein localization to kinetochore	condensed chromosome outer kinetochore|cytosol|microtubule organizing center|nucleus|spindle pole	kinetochore binding|protein binding			ovary(1)|liver(1)	2	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCTAGAACTTCTTATTACTAA	0.383													11	23					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169144387	169144387	+	Splice_Site	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:169144387G>A	uc003maf.2	+	21	2112	c.2032_splice	c.e21-1	p.I678_splice	DOCK2_uc011der.1_Splice_Site|DOCK2_uc010jjm.2_Splice_Site_p.I170_splice	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2						actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATCTTCCTCAGATTTACATAA	0.463													48	12					0	0	1	0	0
NKX2-5	1482	broad.mit.edu	37	5	172659724	172659724	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:172659724G>A	uc003mcm.1	-	2	999	c.823C>T	c.(823-825)CCC>TCC	p.P275S		NM_004387	NP_004378	P52952	NKX25_HUMAN	NK2 transcription factor related, locus 5	275	Ala/Pro-rich.		P -> T (in ASD-AVCD).		adult heart development|atrial cardiac muscle cell development|atrial septum morphogenesis|heart looping|hemopoiesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell apoptosis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|outflow tract septum morphogenesis|pharyngeal system development|positive regulation of calcium ion transport via voltage-gated calcium channel activity|positive regulation of cardioblast differentiation|positive regulation of cell proliferation|positive regulation of heart contraction|positive regulation of neuron differentiation|positive regulation of sodium ion transport|positive regulation of survival gene product expression|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of cardiac muscle contraction|right ventricular cardiac muscle tissue morphogenesis|septum secundum development|spleen development|thyroid gland development|vasculogenesis|ventricular septum morphogenesis		chromatin binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GGCCCGGCGGGGTAAGCGGCA	0.677													3	5					0	0	1	0	0
CPEB4	80315	broad.mit.edu	37	5	173378897	173378897	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:173378897G>A	uc003mcs.3	+	8	3142	c.1736G>A	c.(1735-1737)CGA>CAA	p.R579Q	CPEB4_uc010jju.1_Missense_Mutation_p.R554Q|CPEB4_uc010jjv.2_Missense_Mutation_p.R562Q|CPEB4_uc011dfg.1_Missense_Mutation_p.R554Q|CPEB4_uc003mct.3_Missense_Mutation_p.R189Q|CPEB4_uc003mcu.3_Missense_Mutation_p.R172Q	NM_030627	NP_085130	Q17RY0	CPEB4_HUMAN	cytoplasmic polyadenylation element binding	579							nucleotide binding|RNA binding				0	Renal(175;0.000159)|Lung NSC(126;0.0128)|all_lung(126;0.0202)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CTTGACCCACGAAAAACTATA	0.428													19	29					0	0	1	0	0
FGFR4	2264	broad.mit.edu	37	5	176517623	176517623	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:176517623C>T	uc003mfl.2	+	3	491	c.324C>T	c.(322-324)ATC>ATT	p.I108I	FGFR4_uc003mfm.2_Silent_p.I108I|FGFR4_uc011dfu.1_Silent_p.I108I|FGFR4_uc011dfv.1_RNA|FGFR4_uc003mfn.1_Silent_p.I108I|FGFR4_uc011dfw.1_Silent_p.I108I|FGFR4_uc003mfo.2_Silent_p.I108I	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	108	Ig-like C2-type 1.|Extracellular (Potential).				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	GCTCCATGATCGTCCTGCAGA	0.597										TSP Lung(9;0.080)			26	8					0	0	1	0	0
GRK6	2870	broad.mit.edu	37	5	176863138	176863138	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:176863138C>T	uc011dfz.1	+	12	1282	c.1122C>T	c.(1120-1122)CTC>CTT	p.L374L	GRK6_uc003mgp.2_Silent_p.L374L|GRK6_uc003mgq.2_Silent_p.L374L|GRK6_uc003mgs.1_Silent_p.L344L	NM_002082	NP_002073	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6 isoform B	374	Protein kinase.				regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)|stomach(1)|breast(1)	3	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCGGCTGCCTCCTGTACGAGA	0.637													41	3					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178540923	178540923	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:178540923C>T	uc003mjw.2	-	22	3581	c.3581G>A	c.(3580-3582)AGA>AAA	p.R1194K	uc003mjv.3_5'Flank	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1194					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CTCTTGGATTCTTTGGTTTCT	0.438													72	14					0	0	1	0	0
DUSP22	56940	broad.mit.edu	37	6	348175	348176	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:348175_348176GG>AA	uc003msx.2	+	6	775_776	c.336_337GG>AA	c.(334-339)GAGGAT>GAAAAT	p.D113N	DUSP22_uc011dhn.1_Missense_Mutation_p.D113N|DUSP22_uc003msy.1_Missense_Mutation_p.D70N	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	113	Tyrosine-protein phosphatase.				apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		TTGGCTGGGAGGATGCCCTGCA	0.599													94	284					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6167790	6167790	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:6167790C>T	uc003mwv.2	-	13	1932	c.1809G>A	c.(1807-1809)GCG>GCA	p.A603A	F13A1_uc011dib.1_Silent_p.A540A	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	603					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	AGTGCAGGGACGCTTGTTCCA	0.527													13	43					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7585571	7585571	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:7585571G>A	uc003mxp.1	+	24	8355	c.8076G>A	c.(8074-8076)CAG>CAA	p.Q2692Q	DSP_uc003mxq.1_Silent_p.Q2093Q	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2692	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGCCTGCTCAGAAAGCCTTCA	0.557													58	102					0	0	1	0	0
PIP5K1P1	206426	broad.mit.edu	37	6	7987244	7987244	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:7987244G>A	uc003mxx.3	+	1	910	c.475G>A	c.(475-477)GAA>AAA	p.E159K	TXNDC5_uc003mxw.2_Intron	NR_027712				RecName: Full=Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;          Short=PtdIns(4)P-5-kinase alpha;          Short=PIP5KIalpha;          EC=2.7.1.68; AltName: Full=Phosphatidylinositol-4-phosphate 5-kinase type I alpha; AltName: Full=68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha;												0						GCCGCTGATTGAACTCTGTAG	0.502													13	16					0	0	1	0	0
C6orf105	84830	broad.mit.edu	37	6	11735908	11735908	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:11735908G>A	uc003nab.2	-	4	687	c.399C>T	c.(397-399)TTC>TTT	p.F133F	C6orf105_uc003naa.2_RNA|C6orf105_uc011dip.1_Silent_p.F151F	NM_032744	NP_116133	Q96IZ2	CF105_HUMAN	hypothetical protein LOC84830 isoform 2	133	Helical; (Potential).					integral to membrane					0	Ovarian(93;0.0848)|Breast(50;0.0871)	all_hematologic(90;0.135)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.193)			TGGGGAATATGAAAGTGTGCT	0.507													19	17					0	0	1	0	0
GFOD1	54438	broad.mit.edu	37	6	13365276	13365276	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:13365276G>A	uc003nat.1	-	2	1537	c.872C>T	c.(871-873)CCG>CTG	p.P291L	GFOD1_uc003nas.1_Missense_Mutation_p.P188L	NM_018988	NP_061861	Q9NXC2	GFOD1_HUMAN	glucose-fructose oxidoreductase domain	291						extracellular region	binding|oxidoreductase activity			ovary(2)	2	Breast(50;0.0296)|Ovarian(93;0.0454)	all_hematologic(90;0.135)	Epithelial(50;0.0348)|BRCA - Breast invasive adenocarcinoma(129;0.1)|all cancers(50;0.108)			GGCCTTCTCCGGAAGCAGGGA	0.697													27	83					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24596496	24596496	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:24596496C>T	uc011djo.1	-	3	643	c.406G>A	c.(406-408)GAT>AAT	p.D136N	KIAA0319_uc011djp.1_Missense_Mutation_p.D91N|KIAA0319_uc003neh.1_Missense_Mutation_p.D136N|KIAA0319_uc011djq.1_Missense_Mutation_p.D127N|KIAA0319_uc011djr.1_Missense_Mutation_p.D136N	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	136	Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						TTTCTGATATCCTCAGGTGAG	0.567													29	58					0	0	1	0	0
SLC17A2	10246	broad.mit.edu	37	6	25913647	25913647	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:25913647G>A	uc011dkb.1	-	11	1418	c.1335C>T	c.(1333-1335)TTC>TTT	p.F445F	SLC17A2_uc011dkc.1_3'UTR|SLC17A2_uc003nfl.2_Missense_Mutation_p.S396F			O00624	NPT3_HUMAN	SubName: Full=Solute carrier family 17 (Sodium phosphate), member 2, isoform CRA_b; SubName: Full=Putative uncharacterized protein SLC17A2;	Error:Variant_position_missing_in_O00624_after_alignment					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			ovary(1)	1						CAGCAGACAGGAAAAAGACAT	0.453													26	17					0	0	1	0	0
BTN2A1	11120	broad.mit.edu	37	6	26460004	26460004	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:26460004C>T	uc003nib.1	+	3	590	c.378C>T	c.(376-378)TAC>TAT	p.Y126Y	BTN2A1_uc003nic.1_Silent_p.Y126Y|BTN2A1_uc003nid.1_5'UTR|BTN2A1_uc011dko.1_Silent_p.Y65Y	NM_007049	NP_008980	Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1 isoform 1	126	Extracellular (Potential).|Ig-like V-type.				lipid metabolic process	integral to plasma membrane				ovary(1)|skin(1)	2						ACCGCTGTTACTTCCAAGAAG	0.537													26	39					0	0	1	0	0
GPX5	2880	broad.mit.edu	37	6	28501757	28501757	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:28501757C>T	uc003nll.2	+	5	481	c.479C>T	c.(478-480)TCT>TTT	p.S160F	GPX5_uc003nlm.2_3'UTR|GPX5_uc003nln.2_RNA	NM_001509	NP_001500	O75715	GPX5_HUMAN	glutathione peroxidase 5 isoform 1 precursor	160					lipid metabolic process|response to oxidative stress	extracellular region	glutathione peroxidase activity			skin(1)	1					Glutathione(DB00143)	CCTCATCCCTCTGAGATTTTG	0.453													53	131					0	0	1	0	0
UBD	10537	broad.mit.edu	37	6	29524120	29524120	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:29524120A>T	uc003nmo.2	-	2	259	c.35T>A	c.(34-36)GTC>GAC	p.V12D	GABBR1_uc003nmp.3_3'UTR	NM_006398	NP_006389	O15205	UBD_HUMAN	ubiquitin D	12	Ubiquitin 1.				aggresome assembly|myeloid dendritic cell differentiation|negative regulation of mitotic prometaphase|positive regulation of apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein ubiquitination|response to interferon-gamma|response to tumor necrosis factor|ubiquitin-dependent protein catabolic process	aggresome|cytoplasm|nucleus	proteasome binding				0						CTCGGAACGGACATGCACCTG	0.488													31	32					0	0	1	0	0
TRIM10	10107	broad.mit.edu	37	6	30124759	30124759	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:30124759G>A	uc003npo.3	-	5	928	c.852C>T	c.(850-852)CCC>CCT	p.P284P	TRIM10_uc003npn.2_Silent_p.P284P	NM_006778	NP_006769	Q9UDY6	TRI10_HUMAN	tripartite motif-containing 10 isoform 1	284						cytoplasm	zinc ion binding				0						GGGCCTGCTGGGGAAAGTCCC	0.498													41	75					0	0	1	0	0
TRIM15	89870	broad.mit.edu	37	6	30136262	30136262	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:30136262G>A	uc010jrx.2	+	3	1142	c.663G>A	c.(661-663)AAG>AAA	p.K221K		NM_033229	NP_150232	Q9C019	TRI15_HUMAN	tripartite motif protein 15	221	Potential.				mesodermal cell fate determination	intracellular	zinc ion binding				0						CCCAGGTCAAGGAGCTGGAGG	0.547													10	16					0	0	1	0	0
VARS2	57176	broad.mit.edu	37	6	30883522	30883522	+	Splice_Site	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:30883522G>A	uc003nsc.1	+	4	1017	c.385_splice	c.e4-1	p.A129_splice	VARS2_uc003nsd.2_Splice_Site_p.A129_splice|VARS2_uc011dmx.1_Splice_Site_p.A129_splice|VARS2_uc011dmy.1_Splice_Site|VARS2_uc011dmz.1_Splice_Site_p.A159_splice|VARS2_uc011dna.1_Splice_Site_p.A129_splice|VARS2_uc011dnb.1_Splice_Site|VARS2_uc011dnc.1_Splice_Site	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial						valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4						TCTTCCTCTAGGCCCGGCTGC	0.527													65	69					0	0	1	0	0
LTB	4050	broad.mit.edu	37	6	31550142	31550142	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:31550142G>A	uc003nuk.2	-	1	61	c.53C>T	c.(52-54)TCC>TTC	p.S18F	LTB_uc003nul.2_Missense_Mutation_p.S18F	NM_002341	NP_002332	Q06643	TNFC_HUMAN	lymphotoxin-beta isoform a	18	Cytoplasmic (Potential).				cell-cell signaling|immune response|positive regulation of interleukin-12 biosynthetic process|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding				0					Infliximab(DB00065)|Simvastatin(DB00641)	TAGCAGGAGGGAACCCCTCCC	0.637													15	33					0	0	1	0	0
BAT2	7916	broad.mit.edu	37	6	31592981	31592981	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:31592981C>T	uc003nvb.3	+	6	746	c.497C>T	c.(496-498)TCT>TTT	p.S166F	BAT2_uc011dnv.1_RNA|BAT2_uc003nvc.3_Missense_Mutation_p.S166F|BAT2_uc003nve.2_Missense_Mutation_p.S29F	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	166	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						TCACGATTCTCTCGAGAGGAA	0.552													59	61					0	0	1	0	0
BAT2	7916	broad.mit.edu	37	6	31599352	31599352	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:31599352C>T	uc003nvb.3	+	16	3151	c.2902C>T	c.(2902-2904)CCC>TCC	p.P968S	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.P968S	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	968	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						GCCTCCCAAGCCCCTCGAACA	0.612													8	8					0	0	1	0	0
BAT5	7920	broad.mit.edu	37	6	31655430	31655430	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:31655430G>A	uc003nvy.1	-	18	1565	c.1535C>T	c.(1534-1536)CCC>CTC	p.P512L	BAT5_uc003nvx.1_Missense_Mutation_p.P293L|BAT5_uc011dny.1_Missense_Mutation_p.P479L|BAT5_uc003nvz.1_Missense_Mutation_p.P293L|BAT5_uc011dnz.1_Missense_Mutation_p.P293L	NM_021160	NP_066983	O95870	ABHGA_HUMAN	HLA-B associated transcript 5	512						integral to membrane	hydrolase activity|protein binding				0						CACGCTCCAGGGGAAGTCGGG	0.597													4	59					0	0	1	0	0
LY6G6F	259215	broad.mit.edu	37	6	31675750	31675750	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:31675750G>A	uc003nwa.1	+	3	485	c.485G>A	c.(484-486)GGG>GAG	p.G162E	BAT5_uc011dnz.1_Intron|LY6G6F_uc003nwb.1_Missense_Mutation_p.G162E	NM_001003693	NP_001003693	Q5SQ64	LY66F_HUMAN	G6f protein precursor	162	Extracellular (Potential).					integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)	2						TGGCAGGAAGGGAAGGGTCCC	0.627													43	37					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31914898	31914898	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:31914898G>A	uc003nyj.3	+	3	691	c.413G>A	c.(412-414)CGG>CAG	p.R138Q	CFB_uc011dor.1_Missense_Mutation_p.R640Q|CFB_uc003nyi.2_Missense_Mutation_p.R138Q	NM_001710	NP_001701	P00751	CFAB_HUMAN	complement factor B preproprotein	138	Sushi 2.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			skin(1)	1						TACACTCTCCGGGGCTCTGCC	0.562													4	185					0	0	1	0	0
PBX2	5089	broad.mit.edu	37	6	32154610	32154610	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:32154610C>T	uc003oav.1	-	7	1364	c.1093G>A	c.(1093-1095)GAT>AAT	p.D365N	AGER_uc003oar.2_5'Flank|AGER_uc011dpm.1_5'Flank|AGER_uc011dpn.1_5'Flank|AGER_uc003oal.1_5'Flank|AGER_uc010jtv.1_5'Flank|AGER_uc011dpo.1_5'Flank|AGER_uc003oam.1_5'Flank|AGER_uc003oan.1_5'Flank|AGER_uc003oap.1_5'Flank|AGER_uc003oat.1_5'Flank|AGER_uc003oao.1_5'Flank|AGER_uc003oaq.1_5'Flank|AGER_uc010jtw.1_5'Flank|AGER_uc003oas.1_5'Flank|AGER_uc003oau.1_5'Flank|AGER_uc011dpp.1_5'Flank|AGER_uc011dpq.1_5'Flank|AGER_uc011dpr.1_5'Flank|AGER_uc011dps.1_5'Flank	NM_002586	NP_002577	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	365							transcription factor binding			ovary(1)	1						GAATAGGAATCTCCGTTGAGC	0.512													49	46					0	0	1	0	0
C6orf10	10665	broad.mit.edu	37	6	32260813	32260813	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:32260813G>A	uc011dpy.1	-	12	1810	c.1637C>T	c.(1636-1638)TCG>TTG	p.S546L	C6orf10_uc011dpx.1_Intron	NM_006781	NP_006772	Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	546	Lys-rich.					integral to membrane				skin(1)	1						CGCCCTTTTCGAGCCTTTTGA	0.214													18	32					0	0	1	0	0
HLA-DQB1	3119	broad.mit.edu	37	6	32629825	32629825	+	Missense_Mutation	SNP	C	T	T	rs76620513		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:32629825C>T	uc003obw.2	-	3	662	c.580G>A	c.(580-582)GAA>AAA	p.E194K	HLA-DQB1_uc010juc.1_Missense_Mutation_p.E149K|HLA-DQB1_uc003obv.2_Missense_Mutation_p.E194K|HLA-DQB1_uc011dqd.1_Missense_Mutation_p.E194K|HLA-DQB1_uc011dqe.1_3'UTR	NM_002123	NP_002114	P01920	DQB1_HUMAN	major histocompatibility complex, class II, DQ	194	Extracellular (Potential).|Beta-2.|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GGAGTCATTTCCAGCATCACC	0.567									Melanoma_Familial_Clustering_of|ACTH-independent_macronodular_adrenal_hyperplasia|T-cell_Lymphoma_(Cutaneous)__Familial_Clustering_of|Sj_gren_syndrome				69	48					0	0	1	0	0
PPP1R2P1	5505	broad.mit.edu	37	6	32847454	32847454	+	RNA	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:32847454G>A	uc011dqk.1	+	1		c.3200G>A				NR_027771				Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 1 (PPP1R2P1), non-coding RNA.												0						TATGTCGCCAGGATGTTCATT	0.483													28	38					0	0	1	0	0
HLA-DMA	3108	broad.mit.edu	37	6	32917094	32917094	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:32917094G>A	uc003ocm.2	-	4	821	c.735C>T	c.(733-735)ATC>ATT	p.I245I		NM_006120	NP_006111	Q31604	Q31604_HUMAN	major histocompatibility complex, class II, DM	245						integral to membrane|MHC class II protein complex					0						CAATGCCCACGATGATGCCCA	0.587													49	50					0	0	1	0	0
HLA-DPA1	3113	broad.mit.edu	37	6	33036535	33036535	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:33036535G>A	uc003ocs.1	-	4	706	c.675C>T	c.(673-675)CTC>CTT	p.L225L	HLA-DPA1_uc010juk.2_Silent_p.L225L	NM_033554	NP_291032	P20036	DPA1_HUMAN	major histocompatibility complex, class II, DP	225	Helical; (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			skin(1)	1						CCAGGGCACAGAGCACAGTCT	0.612													71	46					0	0	1	0	0
ZBTB22	9278	broad.mit.edu	37	6	33283498	33283498	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:33283498G>A	uc003oeb.2	-	2	1348	c.1196C>T	c.(1195-1197)TCA>TTA	p.S399L	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Missense_Mutation_p.S399L	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	399					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGGCCCCCCTGAGTCATCAAG	0.617													108	213					0	0	1	0	0
ZBTB9	221504	broad.mit.edu	37	6	33423088	33423089	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:33423088_33423089CC>TT	uc003oeq.2	+	2	479_480	c.211_212CC>TT	c.(211-213)CCT>TTT	p.P71F		NM_152735	NP_689948	Q96C00	ZBTB9_HUMAN	zinc finger and BTB domain containing 9	71	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGCTGCCTCTCCTTACTTCCAT	0.554													93	343					0	0	1	0	0
TEAD3	7005	broad.mit.edu	37	6	35454395	35454395	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:35454395G>A	uc003oku.3	-	2	281	c.45C>T	c.(43-45)GCC>GCT	p.A15A	TEAD3_uc010jvx.2_5'UTR	NM_003214	NP_003205	Q99594	TEAD3_HUMAN	TEA domain family member 3	15					female pregnancy|hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CATCCTCCCGGGCCTCCCCGG	0.701													40	27					0	0	1	0	0
FKBP5	2289	broad.mit.edu	37	6	35547904	35547904	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:35547904G>A	uc011dte.1	-	9	1138	c.935C>T	c.(934-936)TCT>TTT	p.S312F	FKBP5_uc003okx.2_Missense_Mutation_p.S312F|FKBP5_uc011dtf.1_Missense_Mutation_p.S133F|FKBP5_uc003oky.2_Missense_Mutation_p.S312F	NM_001145776	NP_001139248	Q13451	FKBP5_HUMAN	FK506 binding protein 5 isoform 1	312					protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1						AAATGATTCAGAAGCTTTCGA	0.443													82	47					0	0	1	0	0
C6orf81	221481	broad.mit.edu	37	6	35704998	35704998	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:35704998G>A	uc003ola.2	+	1	140	c.113G>A	c.(112-114)GGC>GAC	p.G38D	LOC285847_uc010jvy.1_5'Flank|C6orf81_uc003olb.1_Missense_Mutation_p.G38D	NM_145028	NP_659465	Q5T9G4	CF081_HUMAN	hypothetical protein LOC221481	38							binding			ovary(1)	1						ATCAAGGCTGGCATAAAATGC	0.617											OREG0017379	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	28					0	0	1	0	0
MAPK13	5603	broad.mit.edu	37	6	36104507	36104507	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:36104507C>T	uc003ols.2	+	7	668	c.570C>T	c.(568-570)GCC>GCT	p.A190A	MAPK13_uc003olt.2_RNA	NM_002754	NP_002745	O15264	MK13_HUMAN	mitogen-activated protein kinase 13	190	Protein kinase.				cell cycle|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|positive regulation of interleukin-6 production|Ras protein signal transduction|response to stress		ATP binding|MAP kinase activity|protein binding			breast(2)|central_nervous_system(1)	3						GGTACCGAGCCCCCGAGGTGA	0.582													18	10					0	0	1	0	0
MDGA1	266727	broad.mit.edu	37	6	37622638	37622638	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:37622638G>A	uc003onu.1	-	5	1829	c.650C>T	c.(649-651)TCT>TTT	p.S217F	MDGA1_uc003onw.3_5'Flank	NM_153487	NP_705691	Q8NFP4	MDGA1_HUMAN	MAM domain containing	217	Ig-like 2.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)	2						GTTACGCACAGACACCTGGCA	0.607													89	159					0	0	1	0	0
MDGA1	266727	broad.mit.edu	37	6	37626042	37626042	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:37626042A>T	uc003onu.1	-	3	1540	c.361T>A	c.(361-363)TCC>ACC	p.S121T		NM_153487	NP_705691	Q8NFP4	MDGA1_HUMAN	MAM domain containing	121	Ig-like 1.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)	2						ACGCGGATGGACTTGATGGCC	0.682													11	9					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38998082	38998082	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:38998082T>G	uc003ooe.1	+	91	13987	c.13387T>G	c.(13387-13389)TTC>GTC	p.F4463V		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TGATTTGACCTTCATCACTGT	0.478													41	84					0	0	1	0	0
GLP1R	2740	broad.mit.edu	37	6	39033567	39033567	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:39033567G>A	uc003ooj.3	+	4	424	c.364G>A	c.(364-366)GAC>AAC	p.D122N	GLP1R_uc003ooh.2_RNA|GLP1R_uc003ooi.2_RNA	NM_002062	NP_002053	P43220	GLP1R_HUMAN	glucagon-like peptide 1 receptor precursor	122	Extracellular (Potential).				activation of adenylate cyclase activity|cAMP-mediated signaling|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	glucagon receptor activity|peptide receptor activity, G-protein coupled			lung(3)|breast(1)|pancreas(1)	5					Exenatide(DB01276)|Glucagon recombinant(DB00040)	GCCCTGGAGGGACTTGTCGGA	0.642													11	17					0	0	1	0	0
PTK7	5754	broad.mit.edu	37	6	43098319	43098319	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:43098319C>T	uc003oub.1	+	5	930	c.732C>T	c.(730-732)TTC>TTT	p.F244F	PTK7_uc003ouc.1_Silent_p.F244F|PTK7_uc003oud.1_Silent_p.F244F|PTK7_uc003oue.1_Silent_p.F244F|PTK7_uc003ouf.1_RNA|PTK7_uc003oug.1_RNA|PTK7_uc011dve.1_Silent_p.F252F|PTK7_uc010jyj.1_5'Flank|PTK7_uc003oua.2_Silent_p.F244F	NM_002821	NP_002812	Q13308	PTK7_HUMAN	PTK7 protein tyrosine kinase 7 isoform a	244	Ig-like C2-type 3.|Extracellular (Potential).				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			ovary(2)|large_intestine(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			AGGCCATGTTCCATTGCCAGT	0.592													46	30					0	0	1	0	0
CAPN11	11131	broad.mit.edu	37	6	44147811	44147811	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:44147811G>A	uc003owt.1	+	14	1589	c.1551G>A	c.(1549-1551)GGG>GGA	p.G517G	CAPN11_uc011dvn.1_Silent_p.G171G	NM_007058	NP_008989	Q9UMQ6	CAN11_HUMAN	calpain 11	517	Domain III.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)|breast(1)	2	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TGCCTCCGGGGGAATATATCA	0.532													49	45					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46658651	46658651	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:46658651C>T	uc003oyj.2	+	1	2786	c.2786C>T	c.(2785-2787)TCA>TTA	p.S929L	TDRD6_uc010jze.2_Missense_Mutation_p.S923L	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	929					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			GCTCTGGCTTCAATTAATGAA	0.333													29	86					0	0	1	0	0
GPR111	222611	broad.mit.edu	37	6	47649305	47649305	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:47649305C>T	uc010jzj.1	+	6	1011	c.1010C>T	c.(1009-1011)TCT>TTT	p.S337F	GPR111_uc010jzk.1_Missense_Mutation_p.S269F|GPR111_uc003oyy.2_RNA	NM_153839	NP_722581	Q8IZF7	GP111_HUMAN	G-protein coupled receptor 111	337	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						CCTTCCCCTTCTCAGGTCATC	0.413													5	153					0	0	1	0	0
PGK2	5232	broad.mit.edu	37	6	49754646	49754646	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:49754646G>A	uc003ozu.2	-	1	362	c.255C>T	c.(253-255)CTC>CTT	p.L85L		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	85					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					GCAAGGATTTGAGCTCAACAG	0.512													41	30					0	0	1	0	0
TFAP2B	7021	broad.mit.edu	37	6	50810880	50810881	+	Silent	DNP	CC	TT	TT	rs112599056	byFrequency	TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:50810880_50810881CC>TT	uc003pag.2	+	7	1324_1325	c.1158_1159CC>TT	c.(1156-1161)ATCCTG>ATTTTG	p.386_387IL>IL		NM_003221	NP_003212	Q92481	AP2B_HUMAN	transcription factor AP-2 beta	386_387				QLCKEFTDLLAQDRTPIGNSRPSPILEPGIQSCLTHFSLIT HGFGAPAICAALTALQNYLTEALKGMDKMFLNNTTTNRHTS GEGPGSKTGDKEEKHRK -> GNFVKNLRIYWRRTGHR (in Ref. 1; CAA71047).	nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0	Lung NSC(77;0.156)					CCAGCCCCATCCTGGAGCCGGG	0.634													74	71					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55638907	55638908	+	Missense_Mutation	DNP	TT	GA	GA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:55638907_55638908TT>GA	uc003pcq.2	-	4	1678_1679	c.966_967AA>TC	c.(964-969)AAAAAT>AATCAT	p.322_323KN>NH	BMP5_uc011dxf.1_Missense_Mutation_p.322_323KN>NH	NM_021073	NP_066551	P22003	BMP5_HUMAN	bone morphogenetic protein 5 preproprotein	322_323					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(2)	2	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			CGGTTTTGATTTTTTCGTTTGT	0.47													19	36					0	0	1	0	0
PHF3	23469	broad.mit.edu	37	6	64394104	64394104	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:64394104G>A	uc003pep.1	+	3	507	c.481G>A	c.(481-483)GCA>ACA	p.A161T	PHF3_uc010kaf.1_Missense_Mutation_p.A161T|PHF3_uc003pem.2_Missense_Mutation_p.A114T|PHF3_uc010kag.1_Missense_Mutation_p.A73T|PHF3_uc010kah.1_5'UTR|PHF3_uc003pen.2_Missense_Mutation_p.A73T|PHF3_uc011dxs.1_Intron|PHF3_uc003peo.2_Missense_Mutation_p.A161T	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	161					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			CACAAAAAAAGCATCTGGGAA	0.393													80	262					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	73023356	73023356	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:73023356C>T	uc003pga.2	+	28	4188	c.4111C>T	c.(4111-4113)CGC>TGC	p.R1371C	RIMS1_uc011dyb.1_Missense_Mutation_p.R768C|RIMS1_uc003pgc.2_Missense_Mutation_p.R820C|RIMS1_uc010kaq.2_Missense_Mutation_p.R691C|RIMS1_uc011dyc.1_Intron|RIMS1_uc010kar.2_Intron|RIMS1_uc011dyd.1_Intron|RIMS1_uc003pgf.2_Missense_Mutation_p.R380C|RIMS1_uc003pgg.2_Intron|RIMS1_uc003pgi.2_Intron|RIMS1_uc003pgh.2_Intron|RIMS1_uc003pgd.2_Missense_Mutation_p.R437C|RIMS1_uc003pge.2_Missense_Mutation_p.R411C|RIMS1_uc011dye.1_Missense_Mutation_p.R177C|RIMS1_uc011dyf.1_Intron	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1371	Ser-rich.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GCAATCTGAGCGCCCCAGGGG	0.423													5	11					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75893013	75893013	+	Silent	SNP	G	A	A	rs147111006	by1000genomes	TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:75893013G>A	uc003phs.2	-	10	1810	c.1644C>T	c.(1642-1644)ATC>ATT	p.I548I	COL12A1_uc003pht.2_Intron|COL12A1_uc003phu.1_Silent_p.I206I	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	548	VWFA 2.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						TCCCATCCGTGATAAGAATCA	0.413													69	14					0	0	1	0	0
BACH2	60468	broad.mit.edu	37	6	90661201	90661201	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:90661201G>A	uc011eab.1	-	7	1433	c.624C>T	c.(622-624)CCC>CCT	p.P208P	BACH2_uc003pnw.2_Silent_p.P208P|BACH2_uc010kch.2_Silent_p.P208P	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	208						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		CGTCAGGCTCGGGCAGCAGGG	0.577													13	36					0	0	1	0	0
USP45	85015	broad.mit.edu	37	6	99883615	99883615	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:99883615G>A	uc003ppx.2	-	18	2955	c.2422C>T	c.(2422-2424)CTT>TTT	p.L808F	USP45_uc003ppv.2_RNA|USP45_uc003ppw.2_Missense_Mutation_p.L488F	NM_001080481	NP_001073950	Q70EL2	UBP45_HUMAN	ubiquitin specific peptidase 45	808					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|breast(1)	2		all_cancers(76;0.000208)|Acute lymphoblastic leukemia(125;8.41e-11)|all_hematologic(75;2.56e-07)|all_epithelial(107;0.122)|Colorectal(196;0.133)		BRCA - Breast invasive adenocarcinoma(108;0.0718)		TCATAGAAAAGAAGGTAGGCT	0.368													40	7					0	0	1	0	0
SIM1	6492	broad.mit.edu	37	6	100841663	100841663	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:100841663C>T	uc003pqj.3	-	10	1477	c.1270G>A	c.(1270-1272)GAT>AAT	p.D424N	SIM1_uc010kcu.2_Missense_Mutation_p.D424N	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	424	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		CCAGGCCTATCGGCGGGGTCC	0.597													44	7					0	0	1	0	0
NR2E1	7101	broad.mit.edu	37	6	108492756	108492756	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:108492756C>T	uc003psg.2	+	2	875	c.120C>T	c.(118-120)TTC>TTT	p.F40F		NM_003269	NP_003260	Q9Y466	NR2E1_HUMAN	nuclear receptor subfamily 2, group E, member 1	40	Nuclear receptor.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(87;8.13e-05)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00866)|Colorectal(196;0.0637)		BRCA - Breast invasive adenocarcinoma(108;0.013)|Epithelial(106;0.0521)|all cancers(137;0.068)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)		CAGGTTTTTTCAAACGGAGCA	0.567													148	17					0	0	1	0	0
FOXO3	2309	broad.mit.edu	37	6	108985241	108985241	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:108985241C>T	uc003psk.2	+	3	1521	c.1205C>T	c.(1204-1206)TCG>TTG	p.S402L	FOXO3_uc003psn.2_Intron|FOXO3_uc003psm.2_Missense_Mutation_p.S402L|FOXO3_uc011ean.1_Missense_Mutation_p.S182L|FOXO3_uc010kdj.1_Missense_Mutation_p.S182L	NM_201559	NP_963853	O43524	FOXO3_HUMAN	forkhead box O3A	402					antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(4)|lung(2)	6		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)		TCCCAGCCATCGCCCACTGGG	0.582													63	9					0	0	1	0	0
WASF1	8936	broad.mit.edu	37	6	110424719	110424720	+	Missense_Mutation	DNP	AG	TA	TA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:110424719_110424720AG>TA	uc003ptv.1	-	9	1591_1592	c.754_755CT>TA	c.(754-756)CTT>TAT	p.L252Y	WASF1_uc003ptw.1_Missense_Mutation_p.L252Y|WASF1_uc003ptx.1_Missense_Mutation_p.L252Y|WASF1_uc003pty.1_Missense_Mutation_p.L252Y	NM_003931	NP_003922	Q92558	WASF1_HUMAN	Wiskott-Aldrich syndrome protein family member	252					actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding				0		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		CAAGGCAGAAAGTGAGTAAGAT	0.366													41	7					0	0	1	0	0
LAMA4	3910	broad.mit.edu	37	6	112455697	112455697	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:112455697C>T	uc003pvu.2	-	26	3838	c.3529G>A	c.(3529-3531)GGA>AGA	p.G1177R	LAMA4_uc003pvv.2_Missense_Mutation_p.G1170R|LAMA4_uc003pvt.2_Missense_Mutation_p.G1170R	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1177	Laminin G-like 2.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		GGAGGAGCTCCTCCAATGTAT	0.398													9	6					0	0	1	0	0
HS3ST5	222537	broad.mit.edu	37	6	114379321	114379321	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:114379321C>T	uc003pwg.3	-	2	173	c.141G>A	c.(139-141)CTG>CTA	p.L47L	uc003pwf.2_Intron|HS3ST5_uc003pwh.3_Silent_p.L47L	NM_153612	NP_705840	Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine)	47	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding	p.L47M(1)		ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		GGGCTCCACCCAGTCGACCTT	0.542													11	12					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117662760	117662760	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:117662760G>A	uc003pxp.1	-	29	4904	c.4705C>T	c.(4705-4707)CGG>TGG	p.R1569W	ROS1_uc011ebi.1_Intron|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1569	Fibronectin type-III 7.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GTGTCTGACCGCACAGTTGTA	0.428			T	GOPC|ROS1	glioblastoma|NSCLC								8	18					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117710685	117710685	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:117710685G>A	uc003pxp.1	-	12	1786	c.1587C>T	c.(1585-1587)ATC>ATT	p.I529I	ROS1_uc011ebi.1_Intron|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	529	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CACATCCCACGATGAATTCAT	0.458			T	GOPC|ROS1	glioblastoma|NSCLC								48	3					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117715387	117715387	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:117715387A>T	uc003pxp.1	-	10	1301	c.1102T>A	c.(1102-1104)TTA>ATA	p.L368I	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	368	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GAAGAAATTAATCCTGAACCT	0.373			T	GOPC|ROS1	glioblastoma|NSCLC								19	5					0	0	1	0	0
THEMIS	387357	broad.mit.edu	37	6	128135017	128135017	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:128135017C>T	uc003qbi.2	-	5	1088	c.769G>A	c.(769-771)GAT>AAT	p.D257N	THEMIS_uc010kfa.2_Missense_Mutation_p.D160N|THEMIS_uc011ebt.1_Missense_Mutation_p.D257N|THEMIS_uc010kfb.2_Missense_Mutation_p.D222N	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	257	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						TCGTAAGAATCAGTGATGTCT	0.353													49	3					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129722452	129722452	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:129722452C>T	uc003qbn.2	+	38	5634	c.5529C>T	c.(5527-5529)AAC>AAT	p.N1843N	LAMA2_uc003qbo.2_Silent_p.N1843N	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1843	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		ATGAAGCCAACCGTCTTGCAG	0.403													14	32					0	0	1	0	0
ENPP3	5169	broad.mit.edu	37	6	131996253	131996253	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:131996253G>A	uc003qcu.3	+	10	1143	c.796G>A	c.(796-798)GCC>ACC	p.A266T	ENPP3_uc010kfn.1_RNA|ENPP3_uc011ecc.1_Missense_Mutation_p.A232T|ENPP3_uc010kfo.1_RNA|ENPP3_uc010kfp.1_RNA|ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Missense_Mutation_p.A266T	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	266	Extracellular (Potential).|Phosphodiesterase.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		AGGTTTAAAAGCCGCTACCTA	0.408													36	5					0	0	1	0	0
MOXD1	26002	broad.mit.edu	37	6	132643979	132643979	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:132643979G>A	uc003qdf.2	-	8	1243	c.1144C>T	c.(1144-1146)CAT>TAT	p.H382Y	MOXD1_uc003qde.2_Missense_Mutation_p.H314Y	NM_015529	NP_056344	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1 isoform 2	382	Lumenal (Potential).				catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			ovary(1)	1	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		GCAAACACATGAATTCCACTT	0.463													23	2					0	0	1	0	0
TAAR5	9038	broad.mit.edu	37	6	132910232	132910232	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:132910232T>A	uc003qdk.2	-	1	646	c.594A>T	c.(592-594)AAA>AAT	p.K198N		NM_003967	NP_003958	O14804	TAAR5_HUMAN	trace amine associated receptor 5	198	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			skin(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00604)|GBM - Glioblastoma multiforme(226;0.015)		AGCCCCAAAATTTATTGAGCA	0.483													37	5					0	0	1	0	0
SASH1	23328	broad.mit.edu	37	6	148855983	148855983	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:148855983C>T	uc003qme.1	+	16	2516	c.2041C>T	c.(2041-2043)CCG>TCG	p.P681S	SASH1_uc011eeb.1_Missense_Mutation_p.P442S|SASH1_uc003qmf.1_Missense_Mutation_p.P91S	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	681	SAM 1.						protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		TATCAGGGACCCGGAACACAG	0.483													34	9					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	160969557	160969557	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:160969557G>A	uc003qtl.2	-	32	5228	c.5108C>T	c.(5107-5109)CCT>CTT	p.P1703L		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	4211	Kringle 37.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GACAGTCGGAGGAGCGACCAC	0.537													44	10					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	161020597	161020597	+	Silent	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:161020597A>G	uc003qtl.2	-	21	3342	c.3222T>C	c.(3220-3222)ACT>ACC	p.T1074T		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3582	Kringle 32.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	AAGCTTGGCAAGTTCTTCCTG	0.498													4	319					0	0	1	0	0
MAP3K4	4216	broad.mit.edu	37	6	161528978	161528978	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:161528978G>A	uc003qtn.2	+	21	4238	c.4096G>A	c.(4096-4098)GGG>AGG	p.G1366R	MAP3K4_uc010kkc.1_Missense_Mutation_p.G1362R|MAP3K4_uc003qto.2_Missense_Mutation_p.G1316R|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_Missense_Mutation_p.G819R|MAP3K4_uc003qtp.2_Missense_Mutation_p.G302R|MAP3K4_uc003qtq.2_Missense_Mutation_p.G55R	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1366	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		CGTCGACACCGGGGAGCTGAT	0.577													12	41					0	0	1	0	0
MLLT4	4301	broad.mit.edu	37	6	168352612	168352612	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:168352612C>T	uc003qwd.2	+	29	4696	c.4554C>T	c.(4552-4554)GAC>GAT	p.D1518D	MLLT4_uc003qwb.1_Silent_p.D1503D|MLLT4_uc003qwc.1_Silent_p.D1519D|MLLT4_uc003qwg.1_Silent_p.D828D	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1519					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		GGAAGCGGGACGCCAAGGAGA	0.612			T	MLL	AL								11	24					0	0	1	0	0
GET4	51608	broad.mit.edu	37	7	927101	927101	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:927101C>T	uc003sjl.1	+	4	503	c.411C>T	c.(409-411)TCC>TCT	p.S137S	GET4_uc003sjj.1_RNA	NM_015949	NP_057033	Q7L5D6	GET4_HUMAN	hypothetical protein LOC51608	137					tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	protein binding				0						GTGGGGGCTCCGGGAAGCTGG	0.642													32	49					0	0	1	0	0
MICALL2	79778	broad.mit.edu	37	7	1484890	1484890	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:1484890G>A	uc003skj.3	-	6	963	c.816C>T	c.(814-816)TCC>TCT	p.S272S	MICALL2_uc003ski.3_5'Flank	NM_182924	NP_891554	Q8IY33	MILK2_HUMAN	MICAL-like 2 isoform 1	272						cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		CCTTCTGTGGGGAACAGGAGG	0.682													14	13					0	0	1	0	0
AMZ1	155185	broad.mit.edu	37	7	2752276	2752276	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:2752276G>A	uc003smr.1	+	7	1622	c.1261G>A	c.(1261-1263)GAA>AAA	p.E421K	AMZ1_uc003sms.1_3'UTR|AMZ1_uc011jwa.1_Missense_Mutation_p.E170K	NM_133463	NP_597720	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	421							metallopeptidase activity|zinc ion binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		CCTGCAGCGGGAAGTGGCAGA	0.697													14	33					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	3991526	3991526	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:3991526G>T	uc003smx.2	+	7	1263	c.1124G>T	c.(1123-1125)AGG>ATG	p.R375M		NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	375	Ig-like C2-type 3.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GAACCGGCCAGGGCGACGGCC	0.587													10	38					1.49906e-05	1.50881e-05	1	1	0
SDK1	221935	broad.mit.edu	37	7	4215446	4215446	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:4215446C>T	uc003smx.2	+	34	5115	c.4976C>T	c.(4975-4977)TCG>TTG	p.S1659L	SDK1_uc010kso.2_Intron|SDK1_uc003smy.2_Missense_Mutation_p.S146L	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1659	Fibronectin type-III 10.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGCTCCACATCGACGATGTGT	0.587													76	145					0	0	1	0	0
FOXK1	221937	broad.mit.edu	37	7	4780636	4780636	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:4780636C>T	uc003snc.1	+	2	738	c.728C>T	c.(727-729)TCC>TTC	p.S243F	FOXK1_uc003sna.1_Missense_Mutation_p.S80F|FOXK1_uc003snb.1_Missense_Mutation_p.S243F	NM_001037165	NP_001032242	P85037	FOXK1_HUMAN	forkhead box K1	243					cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			upper_aerodigestive_tract(1)|skin(1)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		CCCGTCCCCTCCCCGACGGGC	0.701													30	13					0	0	1	0	0
DAGLB	221955	broad.mit.edu	37	7	6476070	6476070	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:6476070C>T	uc003sqa.2	-	3	512	c.342G>A	c.(340-342)CTG>CTA	p.L114L	DAGLB_uc011jwt.1_5'Flank|DAGLB_uc011jwu.1_Silent_p.L114L|DAGLB_uc003sqb.2_Intron|DAGLB_uc003sqc.2_Intron|DAGLB_uc011jwv.1_Intron|DAGLB_uc003sqd.3_Silent_p.L73L|DAGLB_uc011jww.1_Intron	NM_139179	NP_631918	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta isoform 1	114	Helical; (Potential).				lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		AGGCAGCCCCCAGAGAGGCCC	0.537													80	73					0	0	1	0	0
COL28A1	340267	broad.mit.edu	37	7	7491976	7491976	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:7491976C>T	uc003src.1	-	18	1600	c.1483G>A	c.(1483-1485)GTG>ATG	p.V495M	COL28A1_uc011jxe.1_Missense_Mutation_p.V178M|COL28A1_uc003srd.2_Missense_Mutation_p.V50M	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	495					cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		CCAATTCCCACTGGTCCTCGA	0.398													59	46					0	0	1	0	0
ANKMY2	57037	broad.mit.edu	37	7	16644417	16644417	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:16644417A>C	uc003sti.2	-	8	1140	c.940T>G	c.(940-942)TTT>GTT	p.F314V	ANKMY2_uc010ktz.2_RNA	NM_020319	NP_064715	Q8IV38	ANKY2_HUMAN	ankyrin repeat and MYND domain containing 2	314						cilium	zinc ion binding			central_nervous_system(1)	1	Lung NSC(10;0.103)|all_lung(11;0.204)			UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		ACATCCACAAAACCCACCTGG	0.423													34	84					0	0	1	0	0
MACC1	346389	broad.mit.edu	37	7	20199241	20199241	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:20199241T>C	uc003sus.3	-	5	1052	c.743A>G	c.(742-744)GAG>GGG	p.E248G	MACC1_uc010kug.2_Missense_Mutation_p.E248G	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	248					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						TAGAGACACCTCTTGGAATTC	0.473													46	47					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21628998	21628998	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:21628998C>T	uc003svc.2	+	12	2177	c.2146C>T	c.(2146-2148)CTC>TTC	p.L716F		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	716	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AAATGGTCTTCTCTGTGTCAA	0.313									Kartagener_syndrome				25	55					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23792410	23792410	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:23792410G>A	uc003sws.3	+	9	1159	c.1092G>A	c.(1090-1092)ATG>ATA	p.M364I	STK31_uc003swt.3_Missense_Mutation_p.M341I|STK31_uc011jze.1_Missense_Mutation_p.M364I|STK31_uc010kuq.2_Missense_Mutation_p.M341I	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	364							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						ATACCAGAATGAAAAATCTGG	0.338													14	44					0	0	1	0	0
HOXA3	3200	broad.mit.edu	37	7	27149908	27149908	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:27149908C>T	uc011jzl.1	-	2	552	c.352G>A	c.(352-354)GCG>ACG	p.A118T	HOXA3_uc011jzk.1_Intron|HOXA3_uc003syk.2_Missense_Mutation_p.A118T	NM_030661	NP_109377	O43365	HXA3_HUMAN	homeobox A3 isoform a	118	Pro-rich.				angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)	2						ggcgggggcgcggcaggggta	0.303													7	17					0	0	1	0	0
CREB5	9586	broad.mit.edu	37	7	28547322	28547322	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:28547322C>T	uc003szq.2	+	4	648	c.258C>T	c.(256-258)TTC>TTT	p.F86F	CREB5_uc003szo.2_Silent_p.F53F|CREB5_uc003szr.2_Silent_p.F79F	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	86					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						AGCACGAGTTCAGGAAGGCTC	0.562													79	68					0	0	1	0	0
ANLN	54443	broad.mit.edu	37	7	36462335	36462335	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:36462335T>C	uc003tff.2	+	14	2597	c.2393T>C	c.(2392-2394)ATG>ACG	p.M798T	ANLN_uc011kaz.1_Missense_Mutation_p.M710T|ANLN_uc003tfg.2_Missense_Mutation_p.M761T|ANLN_uc010kxe.2_Missense_Mutation_p.M760T	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	798	Localization to the cleavage furrow.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3						AGTGAATTTATGCCATCCAAA	0.398													49	80					0	0	1	0	0
AOAH	313	broad.mit.edu	37	7	36763691	36763691	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:36763691G>A	uc003tfh.3	-	1	464	c.63C>T	c.(61-63)TCC>TCT	p.S21S	AOAH_uc010kxf.2_Silent_p.S21S|AOAH_uc011kba.1_Silent_p.S21S	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	21					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						GAGAGGCCGAGGACTGAAGAG	0.517													30	22					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	37264484	37264484	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:37264484C>T	uc003tfk.1	-	9	1008	c.701G>A	c.(700-702)GGG>GAG	p.G234E	ELMO1_uc011kbc.1_Missense_Mutation_p.G138E|ELMO1_uc010kxg.1_Missense_Mutation_p.G234E	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	234					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						GCATGCTTACCCTTGCAGGTG	0.493													42	111					0	0	1	0	0
INHBA	3624	broad.mit.edu	37	7	41729922	41729922	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:41729922C>T	uc003thq.2	-	2	842	c.607G>A	c.(607-609)GAA>AAA	p.E203K	INHBA_uc003thr.2_Missense_Mutation_p.E203K	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	203					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6						AGCAACAGTTCACTCCTCTCC	0.582										TSP Lung(11;0.080)			17	29					0	0	1	0	0
BLVRA	644	broad.mit.edu	37	7	43843289	43843289	+	Nonsense_Mutation	SNP	G	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:43843289G>T	uc003tir.2	+	7	558	c.475G>T	c.(475-477)GAA>TAA	p.E159*	BLVRA_uc010kxv.2_Nonsense_Mutation_p.E159*	NM_000712	NP_000703	P53004	BIEA_HUMAN	biliverdin reductase A precursor	159					heme catabolic process	cytosol	biliverdin reductase activity|zinc ion binding			ovary(1)	1					NADH(DB00157)	CCCGTTGGAAGAAGAGCGGTT	0.587													127	305					2.65394e-64	2.73645e-64	1	1	0
UBE2D4	51619	broad.mit.edu	37	7	43978038	43978038	+	Silent	SNP	C	T	T	rs146582539	byFrequency	TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:43978038C>T	uc003tja.1	+	2	118	c.33C>T	c.(31-33)ACC>ACT	p.T11T	UBE2D4_uc003tjb.1_5'UTR	NM_015983	NP_057067	Q9Y2X8	UB2D4_HUMAN	ubiquitin-conjugating enzyme E2D 4 (putative)	11					protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination		ATP binding|protein binding|ubiquitin-protein ligase activity				0						AGGAATTAACCGACTTGCAGA	0.488													47	173					0	0	1	0	0
CAMK2B	816	broad.mit.edu	37	7	44281867	44281867	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:44281867G>A	uc003tkq.2	-	10	979	c.769C>T	c.(769-771)CCT>TCT	p.P257S	CAMK2B_uc003tkp.2_Missense_Mutation_p.P257S|CAMK2B_uc003tkx.2_Missense_Mutation_p.P257S|CAMK2B_uc010kyd.2_RNA|CAMK2B_uc003tkr.2_Missense_Mutation_p.P257S|CAMK2B_uc003tks.2_Missense_Mutation_p.P257S|CAMK2B_uc003tku.2_Missense_Mutation_p.P257S|CAMK2B_uc003tkv.2_Missense_Mutation_p.P257S|CAMK2B_uc003tkt.2_Missense_Mutation_p.P257S|CAMK2B_uc003tkw.2_Missense_Mutation_p.P257S|CAMK2B_uc010kyc.2_Missense_Mutation_p.P257S	NM_001220	NP_001211	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II	257	Protein kinase.				interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)|ovary(1)	2						CGCTTGGCAGGGTTGATGGTC	0.632													68	80					0	0	1	0	0
SUN3	256979	broad.mit.edu	37	7	48026965	48026965	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:48026965G>A	uc003tof.2	-	11	1133	c.1036C>T	c.(1036-1038)CGA>TGA	p.R346*	SUN3_uc010kyq.2_Nonsense_Mutation_p.R258*|SUN3_uc003tog.2_Nonsense_Mutation_p.R346*|SUN3_uc011kcf.1_Nonsense_Mutation_p.R334*	NM_152782	NP_689995	Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 1	346	SUN.					integral to membrane				central_nervous_system(1)	1						ACCCTGAATCGATATAAACAA	0.383													46	132					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51258636	51258636	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:51258636C>T	uc003tpr.3	-	4	781	c.596G>A	c.(595-597)AGG>AAG	p.R199K	COBL_uc003tps.2_Missense_Mutation_p.R199K|COBL_uc011kcl.1_Missense_Mutation_p.R199K|COBL_uc010kzc.2_Missense_Mutation_p.R199K|COBL_uc003tpt.2_Missense_Mutation_p.R199K|COBL_uc003tpp.3_5'UTR|COBL_uc003tpq.3_Missense_Mutation_p.R115K	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	199										skin(3)|ovary(2)	5	Glioma(55;0.08)					AATGTTGTCCCTGAGGAGAAC	0.562													30	25					0	0	1	0	0
WBSCR17	64409	broad.mit.edu	37	7	70853291	70853291	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:70853291C>T	uc003tvy.2	+	3	493	c.493C>T	c.(493-495)CTG>TTG	p.L165L	WBSCR17_uc003tvz.2_5'UTR	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	165	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GAACGAGGCCCTGTCGGTGAT	0.537													57	44					0	0	1	0	0
WBSCR17	64409	broad.mit.edu	37	7	71134991	71134991	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:71134991G>A	uc003tvy.2	+	8	1301	c.1301G>A	c.(1300-1302)AGA>AAA	p.R434K	WBSCR17_uc003tvz.2_Missense_Mutation_p.R133K	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	434	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GTCTCCGAAAGAAGAGCATTA	0.463													24	61					0	0	1	0	0
FKBP6	8468	broad.mit.edu	37	7	72744236	72744236	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:72744236G>A	uc003tya.2	+	4	481	c.349G>A	c.(349-351)GCC>ACC	p.A117T	FKBP6_uc003twz.2_Intron|FKBP6_uc011kew.1_Missense_Mutation_p.A112T|FKBP6_uc010lbe.1_RNA|TRIM50_uc003txy.1_5'Flank|TRIM50_uc003txz.1_5'Flank	NM_003602	NP_003593	O75344	FKBP6_HUMAN	FK506 binding protein 6 isoform a	117	PPIase FKBP-type.				protein folding	membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				ACCGAACTACGCCTATGGAAC	0.532													35	76					0	0	1	0	0
POM121C	100101267	broad.mit.edu	37	7	75048688	75048688	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:75048688C>T	uc003udk.3	-	14	3666	c.2781G>A	c.(2779-2781)GCG>GCA	p.A927A		NM_001099415	NP_001092885	A8CG34	P121C_HUMAN	POM121 membrane glycoprotein (rat)-like	1169	Pore side (Potential).				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding				0						CCACTCCAGGCGCAGGGGTGT	0.637													19	36					0	0	1	0	0
DTX2	113878	broad.mit.edu	37	7	76112102	76112102	+	Silent	SNP	G	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:76112102G>T	uc003uff.3	+	5	1102	c.546G>T	c.(544-546)GTG>GTT	p.V182V	DTX2_uc011kgk.1_Silent_p.V91V|DTX2_uc003ufg.3_Silent_p.V182V|DTX2_uc003ufh.3_Silent_p.V182V|DTX2_uc003ufj.3_Silent_p.V182V	NM_020892	NP_065943	Q86UW9	DTX2_HUMAN	deltex 2 isoform a	182					Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding			ovary(1)|skin(1)	2						CTTACCCGGTGACCACCATCA	0.652													14	27					2.31682e-05	2.32852e-05	1	1	0
CCDC146	57639	broad.mit.edu	37	7	76885817	76885817	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:76885817C>T	uc003uga.2	+	6	802	c.675C>T	c.(673-675)GTC>GTT	p.V225V		NM_020879	NP_065930	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	225	Potential.									ovary(1)|central_nervous_system(1)	2		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				GACATCAGGTCGTCCTAAAGG	0.353													28	46					0	0	1	0	0
CACNA2D1	781	broad.mit.edu	37	7	81579779	81579779	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:81579779G>A	uc003uhr.1	-	39	3461	c.3205C>T	c.(3205-3207)CTG>TTG	p.L1069L	uc003uhq.1_5'Flank|CACNA2D1_uc011kgy.1_Silent_p.L281L	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	1081	Helical; (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	ATATACCACAGGGAGGGATTT	0.363													7	10					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87150165	87150165	+	Silent	SNP	G	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:87150165G>T	uc003uiz.1	-	23	3131	c.2713C>A	c.(2713-2715)CGA>AGA	p.R905R	ABCB1_uc011khc.1_Silent_p.R841R	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	905	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	ACAACGGTTCGGAAGTTTTCT	0.413													7	45					1.26484e-09	1.2842e-09	1	1	0
SAMD9L	219285	broad.mit.edu	37	7	92761880	92761880	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:92761880C>T	uc003umh.1	-	5	4621	c.3405G>A	c.(3403-3405)TTG>TTA	p.L1135L	SAMD9L_uc003umj.1_Silent_p.L1135L|SAMD9L_uc003umi.1_Silent_p.L1135L|SAMD9L_uc010lfb.1_Silent_p.L1135L|SAMD9L_uc003umk.1_Silent_p.L1135L|SAMD9L_uc010lfc.1_Silent_p.L1135L|SAMD9L_uc010lfd.1_Silent_p.L1135L|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1135										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TGTTCCCATCCAACCACCATT	0.418													22	32					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94049585	94049585	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:94049585C>G	uc003ung.1	+	35	2591	c.2120C>G	c.(2119-2121)CCT>CGT	p.P707R	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	707			Missing (in OI2A).|Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	cctgctggtcctCGGGGAAGC	0.358										HNSCC(75;0.22)			15	50					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98559063	98559063	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:98559063C>T	uc003upp.2	+	45	6857	c.6648C>T	c.(6646-6648)CTC>CTT	p.L2216L	TRRAP_uc011kis.1_Silent_p.L2198L|TRRAP_uc003upr.2_Silent_p.L1915L	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	2216	Interaction with TP53.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			ACAGCCTTCTCTCGCGCCTGA	0.562													41	89					0	0	1	0	0
CYP3A43	64816	broad.mit.edu	37	7	99445814	99445814	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:99445814G>A	uc003urx.1	+	6	561	c.458G>A	c.(457-459)GGA>GAA	p.G153E	CYP3A43_uc003ury.1_Missense_Mutation_p.G153E|CYP3A43_uc003urz.1_Missense_Mutation_p.G153E|CYP3A43_uc003usa.1_RNA|CYP3A43_uc010lgi.1_Intron|CYP3A43_uc003usb.1_Nonsense_Mutation_p.W15*	NM_057095	NP_476436	Q9HB55	CP343_HUMAN	cytochrome P450, family 3, subfamily A,	153			Missing (in allele CYP3A43*2).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)				Cetirizine(DB00341)|Doxycycline(DB00254)	TCCCAATGTGGAGATATGTTG	0.473													30	23					0	0	1	0	0
C7orf43	55262	broad.mit.edu	37	7	99755311	99755311	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:99755311C>T	uc003utr.2	-	3	762	c.582G>A	c.(580-582)CAG>CAA	p.Q194Q	C7orf43_uc010lgo.2_5'Flank|C7orf43_uc010lgp.2_5'Flank|C7orf43_uc011kjj.1_5'UTR|C7orf43_uc003uts.2_5'UTR	NM_018275	NP_060745	Q8WVR3	CG043_HUMAN	hypothetical protein LOC55262	194											0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GAGATCGGGTCTGCAGCAATC	0.577											OREG0018198	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	49	227					0	0	1	0	0
C7orf51	222950	broad.mit.edu	37	7	100087112	100087112	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:100087112C>T	uc003uvd.1	+	4	1927	c.1768C>T	c.(1768-1770)CTG>TTG	p.L590L	C7orf51_uc003uve.1_Silent_p.L372L	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	590										skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CAAGATCCAGCTGCAGGAGCA	0.632													56	30					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100356181	100356181	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:100356181G>A	uc003uwj.2	+	17	3644	c.3479G>A	c.(3478-3480)GGA>GAA	p.G1160E	ZAN_uc003uwk.2_Missense_Mutation_p.G1160E|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1160	VWFD 1.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TTGGTCTACGGAGACCCTCAT	0.602													7	5					0	0	1	0	0
SRRT	51593	broad.mit.edu	37	7	100485698	100485698	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:100485698C>A	uc003uwy.2	+	19	2630	c.2362C>A	c.(2362-2364)CCA>ACA	p.P788T	SRRT_uc010lhl.1_Missense_Mutation_p.P787T|SRRT_uc003uxa.2_Missense_Mutation_p.P783T|SRRT_uc003uwz.2_Missense_Mutation_p.P784T	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	788	Pro-rich.				cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						ACTCCCCTACCCACACCAGAC	0.607													4	164					0.217242	0.217242	1	1	0
SH2B2	10603	broad.mit.edu	37	7	101957830	101957830	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:101957830G>A	uc011kko.1	+	5	1537	c.1492G>A	c.(1492-1494)GTG>ATG	p.V498M		NM_020979	NP_066189	O14492	SH2B2_HUMAN	SH2B adaptor protein 2	455	SH2.				blood coagulation|insulin receptor signaling pathway|intracellular signal transduction	cytosol|plasma membrane	JAK pathway signal transduction adaptor activity|SH3/SH2 adaptor activity|signal transducer activity				0						TGGGGAGTACGTGCTGACCTT	0.657													8	48					0	0	1	0	0
FBXL13	222235	broad.mit.edu	37	7	102453803	102453803	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:102453803C>T	uc003vaq.2	-	20	2621	c.2194G>A	c.(2194-2196)GAC>AAC	p.D732N	FBXL13_uc010liq.1_Missense_Mutation_p.D265N|FBXL13_uc010lir.1_Missense_Mutation_p.D687N|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Missense_Mutation_p.D704N|FAM185A_uc011klh.1_Intron	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	732											0						GCTGCTTGGTCTTCACTGCTG	0.398													18	31					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103322676	103322676	+	Nonsense_Mutation	SNP	A	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:103322676A>T	uc003vca.2	-	11	1336	c.1176T>A	c.(1174-1176)TAT>TAA	p.Y392*	RELN_uc010liz.2_Nonsense_Mutation_p.Y392*	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	392					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TTCCATGGAAATAAATGGAGT	0.438													50	29					0	0	1	0	0
PIK3CG	5294	broad.mit.edu	37	7	106508615	106508615	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:106508615G>A	uc003vdv.3	+	2	694	c.609G>A	c.(607-609)ACG>ACA	p.T203T	PIK3CG_uc003vdu.2_Silent_p.T203T|PIK3CG_uc003vdw.2_Silent_p.T203T	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	203					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						CGTGGGTGACGTCCAAGCCCC	0.617													29	125					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107703395	107703396	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:107703395_107703396GG>AA	uc010ljo.1	-	23	3189_3190	c.3105_3106CC>TT	c.(3103-3108)CCCCCT>CCTTCT	p.P1036S	LAMB4_uc003vey.2_Missense_Mutation_p.P1036S|LAMB4_uc010ljp.1_Missense_Mutation_p.P5S	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1036	Laminin EGF-like 11.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						CCCCCACCAGGGGGACACTCCA	0.535													21	41					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117175431	117175431	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:117175431C>T	uc003vjd.2	+	6	841	c.709C>T	c.(709-711)CAG>TAG	p.Q237*	CFTR_uc011knq.1_5'UTR	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	237	Helical; Name=4; (Potential).|ABC transmembrane type-1 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TGCCCTTTTTCAGGCTGGGCT	0.433									Cystic_Fibrosis				27	23					0	0	1	0	0
C7orf58	79974	broad.mit.edu	37	7	120911459	120911459	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:120911459G>A	uc003vjq.3	+	22	3290	c.2843G>A	c.(2842-2844)GGG>GAG	p.G948E		NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	948						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					TTTCTACAGGGGAAGTGTGGA	0.323													17	23					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126173060	126173060	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:126173060G>A	uc003vlr.2	-	8	2687	c.2376C>T	c.(2374-2376)ATC>ATT	p.I792I	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Silent_p.I792I|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	792	Helical; Name=6; (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CTAACCAAATGATGCAGGTGG	0.398										HNSCC(24;0.065)			34	35					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126173756	126173756	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:126173756C>T	uc003vlr.2	-	8	1991	c.1680G>A	c.(1678-1680)CAG>CAA	p.Q560Q	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Silent_p.Q560Q|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	560	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TGTTGGGTCTCTGATCCAGAG	0.527										HNSCC(24;0.065)			32	107					0	0	1	0	0
SMO	6608	broad.mit.edu	37	7	128851509	128851509	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:128851509G>A	uc003vor.2	+	11	2114	c.1834G>A	c.(1834-1836)GCT>ACT	p.A612T	SMO_uc003vos.2_Missense_Mutation_p.A287T	NM_005631	NP_005622	Q99835	SMO_HUMAN	smoothened precursor	612	Cytoplasmic (Potential).				adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(19)|large_intestine(10)|central_nervous_system(3)|upper_aerodigestive_tract(2)|biliary_tract(1)|lung(1)|liver(1)	37						TGAGCCCTCAGCTGATGTCTC	0.577			Mis		skin basal cell 								88	66					0	0	1	0	0
FAM40B	57464	broad.mit.edu	37	7	129103954	129103954	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:129103954C>T	uc011koy.1	+	15	1661	c.1621C>T	c.(1621-1623)CTG>TTG	p.L541L	FAM40B_uc003vow.2_Silent_p.L541L|FAM40B_uc011koz.1_Silent_p.L33L	NM_020704	NP_065755	Q9ULQ0	FA40B_HUMAN	hypothetical protein LOC57464 isoform a	541											0						TATCAATATCCTGGCAGATGT	0.493													29	50					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131865363	131865363	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:131865363G>A	uc003vra.3	-	19	3850	c.3621C>T	c.(3619-3621)ATC>ATT	p.I1207I		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1207	IPT/TIG 4.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TGTGCCTGCCGATGAGGTTGG	0.597													52	55					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131887509	131887509	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:131887509C>T	uc003vra.3	-	12	2711	c.2482G>A	c.(2482-2484)GGC>AGC	p.G828S		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	828	PSI 3.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TGGCCTGGGCCCTGGCACCAG	0.637													7	7					0	0	1	0	0
LUZP6	767558	broad.mit.edu	37	7	135636300	135636300	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:135636300G>A	uc003vte.3	-	2	507	c.151C>T	c.(151-153)CTG>TTG	p.L51L	LUZP6_uc010lmv.2_Intron	NM_145808	NP_665807	Q538Z0	LUZP6_HUMAN	myotrophin	Error:Variant_position_missing_in_Q538Z0_after_alignment											0						AGAAATTCCAGGATTTCAAGC	0.388													23	47					0	0	1	0	0
AKR1D1	6718	broad.mit.edu	37	7	137773395	137773395	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:137773395G>A	uc003vtz.2	+	2	211	c.142G>A	c.(142-144)GGG>AGG	p.G48R	AKR1D1_uc011kqb.1_Missense_Mutation_p.G48R|AKR1D1_uc011kqc.1_RNA|AKR1D1_uc011kqd.1_Intron|AKR1D1_uc011kqe.1_Missense_Mutation_p.G48R|AKR1D1_uc011kqf.1_Missense_Mutation_p.G48R	NM_005989	NP_005980	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	48					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			skin(1)	1						TATTGACACAGGGTACCGACA	0.493													17	18					0	0	1	0	0
WEE2	494551	broad.mit.edu	37	7	141419018	141419018	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:141419018G>A	uc003vwn.2	+	4	1138	c.732G>A	c.(730-732)ATG>ATA	p.M244I	FLJ40852_uc011krh.1_Intron|FLJ40852_uc010lnm.2_Intron|FLJ40852_uc010lnn.2_Intron|FLJ40852_uc003vwm.3_Intron|FLJ40852_uc010lno.2_Intron	NM_001105558	NP_001099028	P0C1S8	WEE2_HUMAN	WEE1 homolog 2	244	Protein kinase.				egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2	Melanoma(164;0.0171)					AGCGCTCTATGAAAACTTTTA	0.323													11	32					0	0	1	0	0
OR9A4	130075	broad.mit.edu	37	7	141619542	141619542	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:141619542C>T	uc003vwu.1	+	1	867	c.867C>T	c.(865-867)ATC>ATT	p.I289I		NM_001001656	NP_001001656	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.0171)					ATCCTTTCATCTTCACCCTCC	0.458													5	76					0	0	1	0	0
TRY6	154754	broad.mit.edu	37	7	142479926	142479926	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:142479926G>A	uc011ksq.1	+	2	141	c.58G>A	c.(58-60)GAT>AAT	p.D20N	uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_RNA|uc003wan.1_Intron|TRY6_uc011kso.1_RNA|TRY6_uc011ksr.1_RNA	NR_001296				SubName: Full=Protease, serine, 3; Flags: Fragment;												0						CCCCTTTGATGATGATGACAA	0.547													115	71					0	0	1	0	0
FAM131B	9715	broad.mit.edu	37	7	143054029	143054029	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:143054029C>T	uc003wct.2	-	6	2319	c.613G>A	c.(613-615)GAA>AAA	p.E205K	FAM131B_uc010loz.2_Missense_Mutation_p.E173K|FAM131B_uc003wcu.3_Missense_Mutation_p.E205K|FAM131B_uc010lpa.2_Missense_Mutation_p.E233K	NM_014690	NP_055505	Q86XD5	F131B_HUMAN	hypothetical protein LOC9715 isoform b	205											0	Melanoma(164;0.205)					TCGCTGGCTTCCCAGGCATCT	0.547													46	31					0	0	1	0	0
OR2F2	135948	broad.mit.edu	37	7	143632953	143632954	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:143632953_143632954CC>TT	uc011ktv.1	+	1	628_629	c.628_629CC>TT	c.(628-630)CCT>TTT	p.P210F		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					TCTGATGACACCTTTCTGCCTG	0.505													34	53					0	0	1	0	0
OR6B1	135946	broad.mit.edu	37	7	143701590	143701590	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:143701590C>T	uc003wdt.1	+	1	501	c.501C>T	c.(499-501)AGC>AGT	p.S167S		NM_001005281	NP_001005281	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B,	167	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.0783)					CCTGCCTCAGCTTCTGTGGTC	0.502													22	28					0	0	1	0	0
TPK1	27010	broad.mit.edu	37	7	144288563	144288563	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:144288563G>A	uc003weq.2	-	7	557	c.454C>T	c.(454-456)CCA>TCA	p.P152S	TPK1_uc003weo.2_Intron|TPK1_uc003wep.2_RNA|TPK1_uc003wer.2_Intron|TPK1_uc003wes.2_RNA	NM_022445	NP_071890	Q9H3S4	TPK1_HUMAN	thiamin pyrophosphokinase 1 isoform a	152					thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity			ovary(2)	2					Thiamine(DB00152)	ATTATAATTGGAAAAGGAGTG	0.448													57	57					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325563	150325563	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:150325563C>T	uc003whn.2	-	3	547	c.123G>A	c.(121-123)CTG>CTA	p.L41L	GIMAP6_uc003whm.2_Intron	NM_024711	NP_078987	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	41							GTP binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GAATGAGCCTCAGTCTCCTTG	0.517													119	236					0	0	1	0	0
ABP1	26	broad.mit.edu	37	7	150554823	150554823	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:150554823C>T	uc003why.1	+	3	5483	c.1265C>T	c.(1264-1266)CCC>CTC	p.P422L	ABP1_uc003whz.1_Missense_Mutation_p.P422L|ABP1_uc003wia.1_Missense_Mutation_p.P422L	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	422					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	TTTGAAATGCCCACAGGGGTG	0.572													31	39					0	0	1	0	0
NOS3	4846	broad.mit.edu	37	7	150698342	150698342	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:150698342C>G	uc003wif.2	+	11	1553	c.1257C>G	c.(1255-1257)GAC>GAG	p.D419E	NOS3_uc011kuy.1_Missense_Mutation_p.D213E|NOS3_uc011kuz.1_Missense_Mutation_p.D419E|NOS3_uc011kva.1_Missense_Mutation_p.D419E|NOS3_uc011kvb.1_Missense_Mutation_p.D419E	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	419	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	CCATCGTGGACCACCACGCCG	0.627													33	162					0	0	1	0	0
NOS3	4846	broad.mit.edu	37	7	150698465	150698465	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:150698465C>T	uc003wif.2	+	11	1676	c.1380C>T	c.(1378-1380)TTC>TTT	p.F460F	NOS3_uc011kuy.1_Silent_p.F254F|NOS3_uc011kuz.1_Silent_p.F460F|NOS3_uc011kva.1_Silent_p.F460F|NOS3_uc011kvb.1_Silent_p.F460F	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	460	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	CTCCTGTTTTCCATCAGGAGA	0.607													57	51					0	0	1	0	0
ACCN3	9311	broad.mit.edu	37	7	150745996	150745996	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:150745996G>A	uc003win.2	+	1	392	c.24G>A	c.(22-24)GAG>GAA	p.E8E	ACCN3_uc003wio.2_Silent_p.E8E|ACCN3_uc003wip.2_Silent_p.E8E|ACCN3_uc003wiq.2_RNA	NM_004769	NP_004760	Q9UHC3	ACCN3_HUMAN	amiloride-sensitive cation channel 3 isoform a	8	Cytoplasmic (Potential).				sensory perception|signal transduction	cytoplasm|integral to plasma membrane	ligand-gated sodium channel activity			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CAGGCCCAGAGGAGGCCCGGC	0.672													33	101					0	0	1	0	0
ASB10	136371	broad.mit.edu	37	7	150878460	150878460	+	Silent	SNP	G	T	T	rs138770241		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:150878460G>T	uc003wjm.1	-	3	931	c.805C>A	c.(805-807)CGG>AGG	p.R269R	ASB10_uc003wjl.1_Silent_p.R269R|ASB10_uc003wjn.1_Silent_p.R209R	NM_001142459	NP_001135931	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box-containing 10	224	ANK 4.				intracellular signal transduction						0			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGCCAAGCCGGGCGGCCACA	0.627													19	39					8.34094e-07	8.42562e-07	1	1	0
DPP6	1804	broad.mit.edu	37	7	154667733	154667733	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:154667733C>T	uc003wlk.2	+	20	2130	c.2001C>T	c.(1999-2001)TTC>TTT	p.F667F	DPP6_uc003wli.2_Silent_p.F603F|DPP6_uc003wlm.2_Silent_p.F605F|DPP6_uc011kvq.1_Silent_p.F560F	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	667	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GCAGCGGCTTCCAAGGGACCA	0.657													12	7					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2071188	2071188	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:2071188G>A	uc003wpx.3	+	29	3655	c.3517G>A	c.(3517-3519)GAG>AAG	p.E1173K	MYOM2_uc011kwi.1_Missense_Mutation_p.E598K	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	1173	Ig-like C2-type 4.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		GTATGAAACGGAGACACTGCC	0.423													49	65					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2831998	2831998	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:2831998C>T	uc011kwk.1	-	56	9108	c.8718G>A	c.(8716-8718)TGG>TGA	p.W2906*	CSMD1_uc011kwj.1_Nonsense_Mutation_p.W2235*|CSMD1_uc010lrg.2_Nonsense_Mutation_p.W916*	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2906	Sushi 21.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTGCCCCGCTCCAGTGACTGT	0.502													26	38					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3267006	3267006	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:3267006C>T	uc011kwk.1	-	13	2076	c.1686G>A	c.(1684-1686)GGG>GGA	p.G562G	CSMD1_uc011kwj.1_5'UTR	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	562	Extracellular (Potential).|Sushi 3.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TAACTCTCTCCCCCACCAGCT	0.562													14	19					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10469316	10469316	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:10469316C>T	uc003wtc.2	-	4	2521	c.2292G>A	c.(2290-2292)GGG>GGA	p.G764G		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	764					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		ACCCCGCGTCCCCTGCCCACC	0.652													64	66					0	0	1	0	0
C8orf74	203076	broad.mit.edu	37	8	10557855	10557855	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:10557855G>A	uc003wtd.1	+	4	788	c.759G>A	c.(757-759)CAG>CAA	p.Q253Q	C8orf74_uc003wte.1_RNA	NM_001040032	NP_001035121	Q6P047	CH074_HUMAN	hypothetical protein LOC203076	253											0				COAD - Colon adenocarcinoma(149;0.0811)		TGAAGCTTCAGAAGAAGACTC	0.612													29	76					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12973120	12973120	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:12973120G>A	uc003wwm.2	-	6	1839	c.1395C>T	c.(1393-1395)TTC>TTT	p.F465F	DLC1_uc003wwk.1_Silent_p.F28F|DLC1_uc003wwl.1_Silent_p.F62F|DLC1_uc011kxx.1_5'UTR	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	465	SAM.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						CATACTGGGGGAAACCAGTTG	0.423													32	38					0	0	1	0	0
NAT2	10	broad.mit.edu	37	8	18257755	18257756	+	Missense_Mutation	DNP	CA	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:18257755_18257756CA>TT	uc003wyw.1	+	2	349_350	c.242_243CA>TT	c.(241-243)ACA>ATT	p.T81I		NM_000015	NP_000006	P11245	ARY2_HUMAN	N-acetyltransferase 2	81					xenobiotic metabolic process	cytosol	arylamine N-acetyltransferase activity			ovary(1)|skin(1)	2				Colorectal(111;0.0531)|COAD - Colon adenocarcinoma(73;0.21)		GCTCTGACCACAATCGGTTTTC	0.465									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				18	74					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18729967	18729967	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:18729967G>A	uc003wza.2	-	3	510	c.407C>T	c.(406-408)TCA>TTA	p.S136L		NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	136					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		TTTCAGAGCTGAAATCAAAGA	0.458													89	97					0	0	1	0	0
SLC18A1	6570	broad.mit.edu	37	8	20022406	20022406	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:20022406G>A	uc011kyq.1	-	11	1460	c.989C>T	c.(988-990)ACC>ATC	p.T330I	SLC18A1_uc003wzl.2_Missense_Mutation_p.T117I|SLC18A1_uc003wzm.2_Missense_Mutation_p.T330I|SLC18A1_uc011kyr.1_Missense_Mutation_p.T330I|SLC18A1_uc003wzn.2_Intron|SLC18A1_uc010ltf.2_RNA|SLC18A1_uc003wzo.2_Intron	NM_001135691	NP_001129163	P54219	VMAT1_HUMAN	solute carrier family 18 (vesicular monoamine),	330	Lumenal, vesicle (Potential).				neurotransmitter transport	clathrin sculpted monoamine transport vesicle membrane|integral to membrane|membrane fraction	drug transmembrane transporter activity|monoamine transmembrane transporter activity			ovary(2)	2				Colorectal(74;0.0747)		GGAGCACATGGTCTGCATCAT	0.617													49	62					0	0	1	0	0
XPO7	23039	broad.mit.edu	37	8	21846589	21846589	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:21846589C>T	uc003xaa.3	+	16	1965	c.1863C>T	c.(1861-1863)TCC>TCT	p.S621S	XPO7_uc010lti.2_Silent_p.S630S|XPO7_uc010ltk.2_Silent_p.S622S	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	621					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		ATGACCTGTCCATTGGATATC	0.438													11	20					0	0	1	0	0
PHYHIP	9796	broad.mit.edu	37	8	22078975	22078975	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:22078975G>A	uc003xbk.3	-	6	1578	c.884C>T	c.(883-885)TCC>TTC	p.S295F	PHYHIP_uc003xbj.3_Missense_Mutation_p.S295F	NM_001099335	NP_001092805	Q92561	PHYIP_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein	295											0				Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0629)		GGTGCCCAGGGACAGGTCGAC	0.607													102	132					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24188792	24188792	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:24188792G>A	uc003xdy.2	+	12	1316	c.1233G>A	c.(1231-1233)GGG>GGA	p.G411G	ADAM28_uc003xdx.2_Silent_p.G411G|ADAM28_uc011kzz.1_Silent_p.G178G|ADAM28_uc011laa.1_RNA|ADAM28_uc010lua.2_Silent_p.G98G	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	411	Disintegrin.|Extracellular (Potential).				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		CAATTTGTGGGAACCAGTTGG	0.408													20	29					0	0	1	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24256408	24256408	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:24256408C>T	uc003xdz.2	+	9	1004	c.784C>T	c.(784-786)CAA>TAA	p.Q262*	ADAMDEC1_uc010lub.2_Nonsense_Mutation_p.Q183*|ADAMDEC1_uc011lab.1_Nonsense_Mutation_p.Q183*	NM_014479	NP_055294	O15204	ADEC1_HUMAN	ADAM-like, decysin 1 isoform 1	262	Peptidase M12B.				integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)	2		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		CATAGATGTTCAAGTGGCCTT	0.428													33	50					0	0	1	0	0
ADAM7	8756	broad.mit.edu	37	8	24344791	24344791	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:24344791C>T	uc003xeb.2	+	11	1165	c.1052C>T	c.(1051-1053)ACC>ATC	p.T351I	ADAM7_uc003xec.2_Missense_Mutation_p.T123I	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	351	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		TTCCCATGCACCTGTCCTTCA	0.398													19	48					0	0	1	0	0
ADAM7	8756	broad.mit.edu	37	8	24359083	24359083	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:24359083C>T	uc003xeb.2	+	20	2315	c.2202C>T	c.(2200-2202)TTC>TTT	p.F734F	ADAM7_uc003xec.2_Silent_p.F506F	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	734	Cytoplasmic (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		AAATTCATTTCCTAAATGTAA	0.383													22	22					0	0	1	0	0
PPP2R2A	5520	broad.mit.edu	37	8	26218498	26218498	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:26218498C>T	uc003xeu.2	+	6	770	c.468C>T	c.(466-468)GTC>GTT	p.V156V	PPP2R2A_uc003xek.2_Intron|PPP2R2A_uc011laf.1_Silent_p.V166V	NM_002717	NP_002708	P63151	2ABA_HUMAN	alpha isoform of regulatory subunit B55, protein	156					protein dephosphorylation|signal transduction	protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity			ovary(1)|kidney(1)	2		all_cancers(63;0.086)|Ovarian(32;2.61e-05)|all_epithelial(46;0.0514)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.000754)|Epithelial(17;3.02e-15)|all cancers(2;1.52e-13)|OV - Ovarian serous cystadenocarcinoma(2;1.89e-10)|Colorectal(74;0.155)		AGGTGCCAGTCTTTAGGCCTA	0.338													35	48					0	0	1	0	0
CHRNA2	1135	broad.mit.edu	37	8	27324800	27324800	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:27324800G>A	uc010lur.2	-	5	1004	c.395C>T	c.(394-396)TCT>TTT	p.S132F	CHRNA2_uc011lal.1_Missense_Mutation_p.S117F|CHRNA2_uc010lus.2_5'UTR	NM_000742	NP_000733	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha	132	Extracellular.					cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(1)	1		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine(DB01336)|Metocurine Iodide(DB00416)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	GACCCTGAGAGATGTGATGTT	0.547													30	70					0	0	1	0	0
TM2D2	83877	broad.mit.edu	37	8	38853913	38853913	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:38853913G>A	uc003xmk.2	-	1	129	c.46C>T	c.(46-48)CAG>TAG	p.Q16*	ADAM9_uc011lcf.1_5'Flank|ADAM9_uc003xmr.2_5'Flank|ADAM9_uc011lcg.1_5'Flank|ADAM9_uc010lwr.2_5'Flank|TM2D2_uc003xml.2_5'UTR|TM2D2_uc003xmm.2_Intron|TM2D2_uc003xmn.2_Intron|ADAM9_uc003xmo.1_5'Flank|ADAM9_uc003xmp.2_5'Flank	NM_078473	NP_510882	Q9BX73	TM2D2_HUMAN	TM2 domain containing 2 isoform a	16						integral to membrane					0		all_lung(54;0.00338)|Lung NSC(58;0.0133)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			AAAGCCGCCTGGCCGCACAGA	0.612													80	107					0	0	1	0	0
SFRP1	6422	broad.mit.edu	37	8	41122769	41122769	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:41122769C>T	uc003xnt.2	-	3	1164	c.862G>A	c.(862-864)GAC>AAC	p.D288N		NM_003012	NP_003003	Q8N474	SFRP1_HUMAN	secreted frizzled-related protein 1 precursor	288	NTR.				brain development|canonical Wnt receptor signaling pathway|cellular response to BMP stimulus|cellular response to estradiol stimulus|cellular response to fibroblast growth factor stimulus|cellular response to heparin|cellular response to hypoxia|cellular response to interleukin-1|cellular response to prostaglandin E stimulus|cellular response to starvation|cellular response to transforming growth factor beta stimulus|cellular response to tumor necrosis factor|cellular response to vitamin D|DNA fragmentation involved in apoptotic nuclear change|dorsal/ventral axis specification|hemopoietic progenitor cell differentiation|hemopoietic stem cell differentiation|menstrual cycle phase|negative regulation of androgen receptor signaling pathway|negative regulation of B cell differentiation|negative regulation of bone remodeling|negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cysteine-type endopeptidase activity|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast apoptosis|negative regulation of fibroblast proliferation|negative regulation of insulin secretion|negative regulation of ossification|negative regulation of osteoblast proliferation|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|osteoblast differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell growth|positive regulation of epithelial cell proliferation|positive regulation of fat cell differentiation|positive regulation of fibroblast apoptosis|positive regulation of focal adhesion assembly|positive regulation of non-canonical Wnt receptor signaling pathway|positive regulation of Rac GTPase activity|positive regulation of smoothened signaling pathway|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|regulation of angiogenesis|regulation of cell cycle process|response to drug|response to organic cyclic compound|vasculature development	cell surface|cytosol|extracellular space|plasma membrane|proteinaceous extracellular matrix	cysteine-type endopeptidase activity|drug binding|frizzled binding|heparin binding|identical protein binding|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)	1	Breast(1;9.19e-13)|Ovarian(28;0.00769)|Colorectal(14;0.0305)|Lung SC(25;0.211)	all_lung(54;0.0034)|Lung NSC(58;0.0134)|Hepatocellular(245;0.023)|Esophageal squamous(32;0.0559)	BRCA - Breast invasive adenocarcinoma(1;1.11e-10)|LUSC - Lung squamous cell carcinoma(45;0.00894)|COAD - Colon adenocarcinoma(11;0.0174)			TTTTTCTTGTCCCACTTGTGG	0.517													17	69					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41551479	41551479	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:41551479C>T	uc003xok.2	-	29	3553	c.3469G>A	c.(3469-3471)GAC>AAC	p.D1157N	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.D473N|ANK1_uc003xoi.2_Missense_Mutation_p.D1157N|ANK1_uc003xoj.2_Missense_Mutation_p.D1157N|ANK1_uc003xol.2_Missense_Mutation_p.D1157N|ANK1_uc003xom.2_Missense_Mutation_p.D1198N	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1157					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CTCGGGTTGTCGGTCCAGGAA	0.657													24	39					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52252198	52252198	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:52252198C>T	uc003xqu.3	-	21	4233	c.4132G>A	c.(4132-4134)GCA>ACA	p.A1378T	PXDNL_uc003xqt.3_Intron	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1378					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TCTCTGAGTGCTGTGATGGTT	0.388													37	40					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52252245	52252245	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:52252245G>A	uc003xqu.3	-	21	4186	c.4085C>T	c.(4084-4086)TCC>TTC	p.S1362F	PXDNL_uc003xqt.3_Intron	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1362					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GAAATCTTGGGAGAACTTTGT	0.373													37	55					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52359642	52359642	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:52359642G>A	uc003xqu.3	-	12	1548	c.1447C>T	c.(1447-1449)CAA>TAA	p.Q483*		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	483	Ig-like C2-type 3.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TATTGGCCTTGATCGTGCTGT	0.468													126	182					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55533636	55533636	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:55533636G>A	uc003xsd.1	+	2	258	c.110G>A	c.(109-111)CGA>CAA	p.R37Q	RP1_uc011ldy.1_Missense_Mutation_p.R37Q	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	37	Doublecortin 1.				axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GTGGCCAAGCGAATCAGTTTC	0.522													55	55					0	0	1	0	0
SGK3	23678	broad.mit.edu	37	8	67706033	67706033	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:67706033C>T	uc003xwr.2	+	2	361	c.62C>T	c.(61-63)TCC>TTC	p.S21F	SGK3_uc003xwp.2_Missense_Mutation_p.S15F|SGK3_uc003xwt.2_Missense_Mutation_p.S21F|SGK3_uc003xwu.2_Missense_Mutation_p.S21F	NM_001033578	NP_001028750	Q96BR1	SGK3_HUMAN	serum/glucocorticoid regulated kinase 3 isoform	21	PX.				cell communication|response to stress	cytoplasmic membrane-bounded vesicle|early endosome	ATP binding|phosphatidylinositol binding|protein serine/threonine kinase activity			ovary(1)|large_intestine(1)|lung(1)|breast(1)	4	Breast(64;0.186)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0046)|OV - Ovarian serous cystadenocarcinoma(28;0.0112)|all cancers(69;0.0141)|BRCA - Breast invasive adenocarcinoma(89;0.206)			ATTCCCAGCTCCGATGAACAC	0.383													21	24					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68950458	68950458	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:68950458C>T	uc003xxv.1	+	7	797	c.770C>T	c.(769-771)TCT>TTT	p.S257F	PREX2_uc003xxu.1_Missense_Mutation_p.S257F|PREX2_uc011lez.1_Missense_Mutation_p.S192F	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	257	PH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						AAAATTTCTTCTGGAAATATT	0.388													7	19					0	0	1	0	0
PKIA	5569	broad.mit.edu	37	8	79514046	79514046	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:79514046C>T	uc003yba.2	+	4	745	c.221C>T	c.(220-222)TCT>TTT	p.S74F	PKIA_uc003ybb.2_Missense_Mutation_p.S74F|PKIA_uc010lzo.2_Missense_Mutation_p.S74F	NM_006823	NP_006814	P61925	IPKA_HUMAN	cAMP-dependent protein kinase inhibitor alpha	74							cAMP-dependent protein kinase inhibitor activity	p.S74S(1)		ovary(1)|central_nervous_system(1)|pancreas(1)	3						GCAGCAAAATCTGAAAGCTAA	0.433													9	15					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87588279	87588279	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:87588279T>C	uc003ydx.2	-	18	2229	c.2183A>G	c.(2182-2184)AAA>AGA	p.K728R	CNGB3_uc010maj.2_Missense_Mutation_p.K585R	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	728	Cytoplasmic (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						ttcattttctttttgtttatc	0.204													9	12					0	0	1	0	0
NBN	4683	broad.mit.edu	37	8	90958432	90958432	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:90958432G>A	uc003yej.1	-	13	2116	c.2006C>T	c.(2005-2007)TCC>TTC	p.S669F	NBN_uc003yei.1_Missense_Mutation_p.S587F|NBN_uc011lgb.1_Missense_Mutation_p.S669F	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	669					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			TGGATTTCTGGAAGTAGAGTT	0.328								Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				21	37					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100123389	100123389	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:100123389G>A	uc003yiv.2	+	6	755	c.644G>A	c.(643-645)CGG>CAG	p.R215Q	VPS13B_uc003yiw.2_Missense_Mutation_p.R215Q|VPS13B_uc003yit.2_Missense_Mutation_p.R215Q|VPS13B_uc003yiu.1_Missense_Mutation_p.R215Q|VPS13B_uc003yis.2_Missense_Mutation_p.R215Q|VPS13B_uc011lgy.1_Missense_Mutation_p.R91Q	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	215					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CTTGATAAACGGAATGCCAGT	0.303													12	52					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103271215	103271216	+	Missense_Mutation	DNP	GA	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:103271215_103271216GA>TT	uc003ykr.1	-	57	8131_8132	c.8098_8099TC>AA	c.(8098-8100)TCA>AAA	p.S2700K	UBR5_uc003yks.1_Missense_Mutation_p.S2699K|UBR5_uc003ykq.2_Missense_Mutation_p.S211K	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	2700	HECT.				cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TGTCCTACCTGATTCATCATTG	0.342													12	40					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110460542	110460542	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:110460542C>T	uc003yne.2	+	39	6051	c.5947C>T	c.(5947-5949)CAT>TAT	p.H1983Y		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1983	Extracellular (Potential).|IPT/TIG 12.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TATGATGCATCATAAGACAAA	0.408										HNSCC(38;0.096)			16	22					0	0	1	0	0
KCNQ3	3786	broad.mit.edu	37	8	133196544	133196544	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:133196544C>T	uc003ytj.2	-	3	773	c.548G>A	c.(547-549)CGA>CAA	p.R183Q	KCNQ3_uc010mdt.2_Missense_Mutation_p.R183Q	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	183					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GCCTTTGTATCGGCAGCAACA	0.547													51	88					0	0	1	0	0
LRRC6	23639	broad.mit.edu	37	8	133627289	133627289	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:133627289G>A	uc003ytk.2	-	8	1043	c.969C>T	c.(967-969)GTC>GTT	p.V323V	LRRC6_uc003ytl.2_RNA	NM_012472	NP_036604	Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	323	CS.					cytoplasm				ovary(1)|kidney(1)	2	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TTTACCTATAGACAGCAAGGT	0.303													25	39					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139164396	139164396	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:139164396G>A	uc003yuy.2	-	13	2493	c.2322C>T	c.(2320-2322)CCC>CCT	p.P774P	FAM135B_uc003yux.2_Silent_p.P675P|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Silent_p.P336P|FAM135B_uc003yvb.2_Silent_p.P336P	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	774										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TACTGATGTGGGGAGCAGATA	0.522										HNSCC(54;0.14)			32	40					0	0	1	0	0
TRAPPC9	83696	broad.mit.edu	37	8	140744261	140744261	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:140744261G>A	uc003yvj.2	-	22	3374	c.3240C>T	c.(3238-3240)ACC>ACT	p.T1080T	TRAPPC9_uc003yvh.2_Silent_p.T1178T	NM_001160372	NP_001153844	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9 isoform	1080					cell differentiation	endoplasmic reticulum|Golgi apparatus				skin(2)	2						CGAAGGAGACGGTGTCGTGCA	0.652													4	14					0	0	1	0	0
CHRAC1	54108	broad.mit.edu	37	8	141525238	141525238	+	Silent	SNP	G	A	A	rs140626835		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:141525238G>A	uc003yvl.2	+	3	486	c.288G>A	c.(286-288)AAG>AAA	p.K96K	CHRAC1_uc010mem.1_RNA	NM_017444	NP_059140	Q9NRG0	CHRC1_HUMAN	chromatin accessibility complex 1	96					chromatin remodeling	chromatin accessibility complex|epsilon DNA polymerase complex	DNA-directed DNA polymerase activity|sequence-specific DNA binding			ovary(1)	1	all_cancers(97;5.52e-16)|all_epithelial(106;1.22e-13)|Lung NSC(106;4.09e-06)|all_lung(105;6e-06)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.107)			TATTACCAAAGAAGATTTTAG	0.343													43	68					0	0	1	0	0
TSTA3	7264	broad.mit.edu	37	8	144697044	144697044	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:144697044G>A	uc003yza.2	-	4	339	c.303C>T	c.(301-303)GCC>GCT	p.A101A	TSTA3_uc003yzb.2_Silent_p.A101A|TSTA3_uc011lko.1_Silent_p.A101A	NM_003313	NP_003304	Q13630	FCL_HUMAN	tissue specific transplantation antigen P35B	101					'de novo' GDP-L-fucose biosynthetic process|leukocyte cell-cell adhesion		coenzyme binding|electron carrier activity|GDP-4-dehydro-D-rhamnose reductase activity|GDP-L-fucose synthase activity|isomerase activity			pancreas(1)	1	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)		NADH(DB00157)	CCACCTCAAAGGCCGAGTGCA	0.612													35	62					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144998534	144998534	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:144998534C>T	uc003zaf.1	-	31	6144	c.5974G>A	c.(5974-5976)GCG>ACG	p.A1992T	PLEC_uc003zab.1_Missense_Mutation_p.A1855T|PLEC_uc003zac.1_Missense_Mutation_p.A1859T|PLEC_uc003zad.2_Missense_Mutation_p.A1855T|PLEC_uc003zae.1_Missense_Mutation_p.A1823T|PLEC_uc003zag.1_Missense_Mutation_p.A1833T|PLEC_uc003zah.2_Missense_Mutation_p.A1841T|PLEC_uc003zaj.2_Missense_Mutation_p.A1882T	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	1992	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TCCTTGAGCGCGATCTCCGCC	0.736													3	28					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	145003384	145003384	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:145003384C>T	uc003zaf.1	-	25	3728	c.3558G>A	c.(3556-3558)AAG>AAA	p.K1186K	PLEC_uc003zab.1_Silent_p.K1049K|PLEC_uc003zac.1_Silent_p.K1053K|PLEC_uc003zad.2_Silent_p.K1049K|PLEC_uc003zae.1_Silent_p.K1017K|PLEC_uc003zag.1_Silent_p.K1027K|PLEC_uc003zah.2_Silent_p.K1035K|PLEC_uc003zaj.2_Silent_p.K1076K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	1186	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GGGCCAAGACCTTCTCGGCCT	0.682													4	14					0	0	1	0	0
PPP1R16A	84988	broad.mit.edu	37	8	145724400	145724400	+	Silent	SNP	G	A	A	rs114186172	by1000genomes	TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:145724400G>A	uc003zdd.2	+	4	1345	c.432G>A	c.(430-432)GCG>GCA	p.A144A	uc003zde.1_5'Flank|PPP1R16A_uc003zdf.2_Silent_p.A144A	NM_032902	NP_116291	Q96I34	PP16A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	144	ANK 3.					plasma membrane	protein binding				0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TGCATGCTGCGGCCACCTGCG	0.627													9	88					0	0	1	0	0
GLDC	2731	broad.mit.edu	37	9	6554674	6554674	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:6554674G>A	uc003zkc.2	-	19	2503	c.2310C>T	c.(2308-2310)ATC>ATT	p.I770I		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	770					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CTTACACTCCGATGGGCCCCA	0.527													11	1					0	0	1	0	0
SH3GL2	6456	broad.mit.edu	37	9	17795610	17795610	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:17795610G>A	uc003zna.2	+	9	1216	c.928G>A	c.(928-930)GGA>AGA	p.G310R	SH3GL2_uc011lmy.1_Missense_Mutation_p.G263R	NM_003026	NP_003017	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	310	SH3.				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			skin(1)	1				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		AGGGGAGTTGGGATTTAAAGA	0.478													8	6					0	0	1	0	0
Unknown	0	broad.mit.edu	37	9	21278401	21278401	+	RNA	SNP	T	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:21278401T>G	uc003zou.1	-	1		c.162A>C								Messenger RNA for human leukocyte (alpha) interferon.																		AGCTTGAACCTTCTGGAAGTG	0.433													6	1					0	0	1	0	0
CDKN2A	1029	broad.mit.edu	37	9	21974684	21974684	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:21974684G>A	uc003zpk.2	-	1	355	c.143C>T	c.(142-144)CCG>CTG	p.P48L	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Missense_Mutation_p.P48L|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Intron	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	48	ANK 2.		P -> L (in CMM2 and a head and neck tumor; somatic mutation).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(25)|p.P48L(9)|p.P48P(1)|p.P48R(1)|p.V28_V51del(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CACCTGGATCGGCCTCCGACC	0.677		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			104	27					0	0	1	0	0
MELK	9833	broad.mit.edu	37	9	36671045	36671045	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:36671045C>T	uc003zzn.2	+	16	1694	c.1556C>T	c.(1555-1557)CCA>CTA	p.P519L	MELK_uc011lpm.1_Missense_Mutation_p.P388L|MELK_uc011lpn.1_Missense_Mutation_p.P478L|MELK_uc011lpo.1_Missense_Mutation_p.P325L|MELK_uc010mll.2_Missense_Mutation_p.P487L|MELK_uc011lpp.1_Missense_Mutation_p.P471L|MELK_uc010mlm.2_Missense_Mutation_p.P448L|MELK_uc011lpq.1_Missense_Mutation_p.P325L|MELK_uc011lpr.1_Missense_Mutation_p.P448L|MELK_uc011lps.1_Missense_Mutation_p.P439L	NM_014791	NP_055606	Q14680	MELK_HUMAN	maternal embryonic leucine zipper kinase	519						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		Acute lymphoblastic leukemia(2;1.09e-08)|all_hematologic(2;8.15e-06)	STAD - Stomach adenocarcinoma(86;0.228)			GAGGAGACTCCAAAAAGAAAG	0.502													28	3					0	0	1	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39140542	39140542	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:39140542G>A	uc004abi.2	-	12	2089	c.1850C>T	c.(1849-1851)CCA>CTA	p.P617L	CNTNAP3_uc004abj.2_Missense_Mutation_p.P617L|CNTNAP3_uc011lqr.1_RNA|CNTNAP3_uc004abk.1_Missense_Mutation_p.P617L|CNTNAP3_uc011lqs.1_Missense_Mutation_p.P524L|CNTNAP3_uc004abl.1_Missense_Mutation_p.P436L	NM_033655	NP_387504	Q9BZ76	CNTP3_HUMAN	cell recognition molecule CASPR3 precursor	617	Fibrinogen C-terminal.|Extracellular (Potential).				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CACAAGAAATGGTCCCAGGGG	0.443													32	9					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72132046	72132046	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:72132046G>A	uc004ahh.2	-	2	357	c.81C>T	c.(79-81)GCC>GCT	p.A27A		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	27					axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						GCTCCAGGTCGGCCTCCACCG	0.687													3	6					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73168133	73168133	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:73168133G>A	uc004aid.2	-	22	3525	c.3281C>T	c.(3280-3282)GCC>GTC	p.A1094V	TRPM3_uc004ahu.2_Missense_Mutation_p.A936V|TRPM3_uc004ahv.2_Missense_Mutation_p.A896V|TRPM3_uc004ahw.2_Missense_Mutation_p.A966V|TRPM3_uc004ahx.2_Missense_Mutation_p.A953V|TRPM3_uc004ahy.2_Missense_Mutation_p.A956V|TRPM3_uc004ahz.2_Missense_Mutation_p.A943V|TRPM3_uc004aia.2_Missense_Mutation_p.A941V|TRPM3_uc004aib.2_Missense_Mutation_p.A931V|TRPM3_uc004aic.2_Missense_Mutation_p.A1094V	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1119	Helical; (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						GAGGTAGCAGGCCATGATGGC	0.537													12	17					0	0	1	0	0
TMC1	117531	broad.mit.edu	37	9	75315533	75315533	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:75315533G>A	uc004aiz.1	+	8	876	c.336G>A	c.(334-336)AAG>AAA	p.K112K	TMC1_uc010moz.1_Intron|TMC1_uc004aja.1_RNA|TMC1_uc004ajb.1_Intron|TMC1_uc004ajc.1_Intron|TMC1_uc010mpa.1_Intron	NM_138691	NP_619636	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	112	Cytoplasmic (Potential).|Arg/Asp/Glu/Lys-rich (highly charged).				sensory perception of sound	integral to membrane				ovary(1)	1						AACCATGGAAGATGGAGAAGA	0.333													16	16					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79320429	79320429	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:79320429C>T	uc010mpk.2	-	8	6885	c.6761G>A	c.(6760-6762)AGC>AAC	p.S2254N	PRUNE2_uc004akj.3_5'Flank|PRUNE2_uc010mpl.1_5'Flank	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2254					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						AGGAGAAAAGCTGTCTGATAT	0.453													6	15					0	0	1	0	0
FLJ46321	389763	broad.mit.edu	37	9	84608238	84608238	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:84608238C>T	uc004amn.2	+	4	2900	c.2853C>T	c.(2851-2853)ATC>ATT	p.I951I		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	951						integral to membrane					0						CCACCTTCATCTCTCAGGGAG	0.478													30	44					0	0	1	0	0
Unknown	0	broad.mit.edu	37	9	84675998	84675998	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:84675998C>T	uc010mpu.1	-	3	430	c.427G>A	c.(427-429)GAA>AAA	p.E143K		NM_001164339	NP_001157811			hypothetical protein LOC404770																		GAGGGGCGTTCTAGGAGAAGG	0.597													114	204					0	0	1	0	0
FRMD3	257019	broad.mit.edu	37	9	85862874	85862874	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:85862874C>T	uc004ams.1	-	14	1955	c.1753G>A	c.(1753-1755)GGG>AGG	p.G585R	FRMD3_uc004amr.1_Intron|FRMD3_uc004amq.1_Intron	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	585						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2						TGGACTTTCCCAGCCACCCAC	0.453													103	130					0	0	1	0	0
C9orf64	84267	broad.mit.edu	37	9	86571209	86571209	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:86571209G>A	uc004anb.2	-	1	455	c.207C>T	c.(205-207)TTC>TTT	p.F69F	C9orf64_uc004anc.2_Intron	NM_032307	NP_115683	Q5T6V5	CI064_HUMAN	hypothetical protein LOC84267	69											0						TGTCTGTCACGAACACCCAGT	0.617													39	31					0	0	1	0	0
NAA35	60560	broad.mit.edu	37	9	88631453	88631453	+	Splice_Site	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:88631453G>A	uc004aoi.3	+	18	1706	c.1569_splice	c.e18-1	p.W523_splice	NAA35_uc004aoj.3_Splice_Site_p.W523_splice	NM_024635	NP_078911	Q5VZE5	NAA35_HUMAN	corneal wound healing-related protein						smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				skin(2)|central_nervous_system(1)	3						TATCCTTTAAGGTATCTCTCT	0.363													21	27					0	0	1	0	0
C9orf79	286234	broad.mit.edu	37	9	90501596	90501597	+	Missense_Mutation	DNP	GA	AC	AC			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:90501596_90501597GA>AC	uc004app.3	+	4	2229_2230	c.2194_2195GA>AC	c.(2194-2196)GAA>ACA	p.E732T	C9orf79_uc004apo.1_Missense_Mutation_p.E544T	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	732						integral to membrane				ovary(3)	3						GGCTCTGGACGAAGACAAGGAG	0.559													11	25					0	0	1	0	0
FAM75C1	441452	broad.mit.edu	37	9	90536813	90536813	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:90536813G>A	uc010mqi.2	+	4	2020	c.1991G>A	c.(1990-1992)AGG>AAG	p.R664K	FAM75C1_uc004apq.3_Missense_Mutation_p.R647K	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						GCCAAACACAGGTGGGGTCTA	0.522													10	96					0	0	1	0	0
SECISBP2	79048	broad.mit.edu	37	9	91949601	91949601	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:91949601C>T	uc004aqj.1	+	7	1125	c.1045C>T	c.(1045-1047)CCT>TCT	p.P349S	SECISBP2_uc010mqn.1_Missense_Mutation_p.P310S|SECISBP2_uc004aqi.1_Missense_Mutation_p.P237S|SECISBP2_uc011ltk.1_Missense_Mutation_p.P348S|SECISBP2_uc004aqk.1_Missense_Mutation_p.P276S|SECISBP2_uc010mqo.1_Missense_Mutation_p.P54S|SECISBP2_uc011ltl.1_Missense_Mutation_p.P281S	NM_024077	NP_076982	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	349					translation	nucleus	mRNA 3'-UTR binding			ovary(2)|skin(1)	3						ATCTTCGGATCCTTCCTACAA	0.274													21	29					0	0	1	0	0
DIRAS2	54769	broad.mit.edu	37	9	93375669	93375669	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:93375669G>A	uc004aqx.1	-	2	552	c.441C>T	c.(439-441)TTC>TTT	p.F147F		NM_017594	NP_060064	Q96HU8	DIRA2_HUMAN	Di-Ras2	147					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity				0						AGGTCTCCATGAAGGCACACT	0.602													9	50					0	0	1	0	0
C9orf129	445577	broad.mit.edu	37	9	96097661	96097661	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:96097661C>T	uc010mre.2	-	3	724	c.360G>A	c.(358-360)GCG>GCA	p.A120A		NM_001098808	NP_001092278	Q5T035	CI129_HUMAN	hypothetical protein LOC445577	120										ovary(1)	1						CTCACTTTGTCGCCCCTCCGC	0.632													12	22					0	0	1	0	0
Unknown	0	broad.mit.edu	37	9	98774978	98774978	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:98774978C>T	uc010msa.1	+	4	1965	c.1089C>T	c.(1087-1089)TCC>TCT	p.S363S	uc011lun.1_Intron					RecName: Full=Uncharacterized protein C9orf102;																		CTGTGACATCCCGTTCTCTGA	0.413													16	13					0	0	1	0	0
LOC441454	441454	broad.mit.edu	37	9	99672523	99672523	+	RNA	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:99672523G>A	uc011luq.1	+	1		c.1167G>A				NR_028350				Homo sapiens prothymosin, alpha pseudogene (LOC441454), non-coding RNA.												0						agatgaagaaggggaagaaag	0.313													3	2					0	0	1	0	0
TBC1D2	55357	broad.mit.edu	37	9	100970981	100970981	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:100970981G>A	uc011lvb.1	-	9	2299	c.2119C>T	c.(2119-2121)CCC>TCC	p.P707S	TBC1D2_uc004ayp.2_Missense_Mutation_p.P247S|TBC1D2_uc004ayq.2_Missense_Mutation_p.P707S|TBC1D2_uc004ayr.2_Missense_Mutation_p.P489S|TBC1D2_uc004ayo.3_Missense_Mutation_p.P707S	NM_018421	NP_060891	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	707	Rab-GAP TBC.					cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			ovary(3)	3		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		CCGATGGTGGGGTTCTGCCAG	0.542													20	44					0	0	1	0	0
GABBR2	9568	broad.mit.edu	37	9	101304234	101304234	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:101304234G>A	uc004ays.2	-	3	707	c.551C>T	c.(550-552)CCA>CTA	p.P184L		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	184	Extracellular (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	CAGAATGGCTGGATTCACCGC	0.507													3	56					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101817609	101817609	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:101817609C>T	uc004azb.1	+	34	3353	c.3147C>T	c.(3145-3147)TTC>TTT	p.F1049F		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	1049	Nonhelical region 8 (NC8).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				ATGGCAGCTTCCTTATGTCTG	0.507													26	38					0	0	1	0	0
INVS	27130	broad.mit.edu	37	9	102866891	102866891	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:102866891C>T	uc004bap.1	+	2	300	c.88C>T	c.(88-90)CTA>TTA	p.L30L	INVS_uc010mta.1_5'UTR|INVS_uc011lve.1_5'UTR|INVS_uc004bao.1_Silent_p.L30L|INVS_uc004baq.1_5'UTR|INVS_uc004bar.1_5'UTR|INVS_uc010mtb.1_5'UTR	NM_014425	NP_055240	Q9Y283	INVS_HUMAN	inversin isoform a	30	ANK 1.				negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|membrane|microtubule|nucleus|spindle	calmodulin binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.056)				TAAGGGTGCTCTACAGAGGCT	0.413													22	28					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104432921	104432921	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:104432921C>T	uc004bbp.1	-	3	2374	c.1773G>A	c.(1771-1773)ATG>ATA	p.M591I	GRIN3A_uc004bbq.1_Missense_Mutation_p.M591I	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	591	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	AGTCAAAGTTCATGTCTTCTG	0.448													3	12					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104433261	104433261	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:104433261C>T	uc004bbp.1	-	3	2034	c.1433G>A	c.(1432-1434)TGG>TAG	p.W478*	GRIN3A_uc004bbq.1_Nonsense_Mutation_p.W478*	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	478	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CAAGCGGGTCCACATTGGCTT	0.498													37	32					0	0	1	0	0
OR13C8	138802	broad.mit.edu	37	9	107331743	107331743	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:107331743G>A	uc011lvo.1	+	1	295	c.295G>A	c.(295-297)GTG>ATG	p.V99M		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	99	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGGGTGTATGGTGCAAATGTT	0.483													16	38					0	0	1	0	0
ABCA1	19	broad.mit.edu	37	9	107568638	107568639	+	Nonsense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:107568638_107568639GG>AA	uc004bcl.2	-	31	4660_4661	c.4347_4348CC>TT	c.(4345-4350)TTCCAG>TTTTAG	p.Q1450*		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	1450	Extracellular.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TTCCCATTCTGGAAGAGGTCCA	0.579													10	19					0	0	1	0	0
KLF4	9314	broad.mit.edu	37	9	110249481	110249481	+	Silent	SNP	T	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:110249481T>C	uc004bdh.2	-	3	1788	c.1167A>G	c.(1165-1167)TCA>TCG	p.S389S	KLF4_uc004bdf.1_Intron|KLF4_uc004bdg.2_Intron	NM_004235	NP_004226	O43474	KLF4_HUMAN	Kruppel-like factor 4 (gut)	398	Pro-rich.				fat cell differentiation|mesodermal cell fate determination|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|stem cell maintenance|transcription from RNA polymerase II promoter	nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(2)|lung(1)	3						GCTCTAGGGGTGAAGAAGGTG	0.627													5	50					0	0	1	0	0
EPB41L4B	54566	broad.mit.edu	37	9	111970318	111970318	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:111970318C>T	uc004bdz.1	-	18	2059	c.1764G>A	c.(1762-1764)AAG>AAA	p.K588K		NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	588						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						CCGAGACTTTCTTTTCTTCAG	0.398													23	31					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113547963	113547963	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:113547963C>T	uc004bey.2	+	12	1841	c.1743C>T	c.(1741-1743)ATC>ATT	p.I581I	MUSK_uc004bez.1_Silent_p.I161I	NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	581	ATP (By similarity).|Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6						TGAGAGACATCGGAGAGGGAG	0.428													10	28					0	0	1	0	0
RNF183	138065	broad.mit.edu	37	9	116060265	116060265	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:116060265G>A	uc004bgz.2	-	2	318	c.200C>T	c.(199-201)TCA>TTA	p.S67L	RNF183_uc004bha.2_Missense_Mutation_p.S67L	NM_145051	NP_659488	Q96D59	RN183_HUMAN	ring finger protein 183	67						integral to membrane	zinc ion binding				0						AGGCTGCCCTGAGGCCAGCAC	0.662													26	24					0	0	1	0	0
AMBP	259	broad.mit.edu	37	9	116823304	116823304	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:116823304C>T	uc004bie.3	-	9	1191	c.928G>A	c.(928-930)GGG>AGG	p.G310R	AMBP_uc011lxk.1_3'UTR	NM_001633	NP_001624	P02760	AMBP_HUMAN	alpha-1-microglobulin/bikunin preproprotein	310	BPTI/Kunitz inhibitor 2.				cell adhesion|female pregnancy|heme catabolic process|interspecies interaction between organisms|negative regulation of immune response|negative regulation of JNK cascade|protein-chromophore linkage	extracellular region|plasma membrane	calcium channel inhibitor activity|calcium oxalate binding|heme binding|IgA binding|protein homodimerization activity|serine-type endopeptidase inhibitor activity|transporter activity			skin(1)	1					Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	ACGCACTTCCCCTTGACAGCA	0.607													16	29					0	0	1	0	0
AMBP	259	broad.mit.edu	37	9	116824957	116824957	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:116824957C>T	uc004bie.3	-	7	948	c.685G>A	c.(685-687)GAT>AAT	p.D229N	AMBP_uc011lxk.1_Missense_Mutation_p.D170N|AMBP_uc010mvc.1_RNA	NM_001633	NP_001624	P02760	AMBP_HUMAN	alpha-1-microglobulin/bikunin preproprotein	229					cell adhesion|female pregnancy|heme catabolic process|interspecies interaction between organisms|negative regulation of immune response|negative regulation of JNK cascade|protein-chromophore linkage	extracellular region|plasma membrane	calcium channel inhibitor activity|calcium oxalate binding|heme binding|IgA binding|protein homodimerization activity|serine-type endopeptidase inhibitor activity|transporter activity			skin(1)	1					Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	TGTTCATTACCTTCTTTCTTG	0.537													30	50					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117808727	117808727	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:117808727C>T	uc004bjj.3	-	17	5449	c.5087G>A	c.(5086-5088)GGA>GAA	p.G1696E	TNC_uc010mvf.2_Intron	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1696	Fibronectin type-III 12.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						GGATCGCCTTCCTTTGCTTAT	0.458													64	86					0	0	1	0	0
DBC1	1620	broad.mit.edu	37	9	122000994	122000994	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:122000994G>T	uc004bkc.2	-	5	1080	c.624C>A	c.(622-624)GAC>GAA	p.D208E	DBC1_uc004bkd.2_Missense_Mutation_p.D208E	NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	208	MACPF.				cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						AGTCCAGATTGTCATAGCTGT	0.502													13	37					6.94344e-10	7.05486e-10	1	1	0
MORN5	254956	broad.mit.edu	37	9	124922255	124922255	+	Nonsense_Mutation	SNP	G	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:124922255G>T	uc004blw.2	+	1	66	c.4G>T	c.(4-6)GAG>TAG	p.E2*	NDUFA8_uc004blv.2_5'Flank|MORN5_uc011lyn.1_Nonsense_Mutation_p.E2*|MORN5_uc011lyo.1_Nonsense_Mutation_p.E2*	NM_198469	NP_940871	Q5VZ52	MORN5_HUMAN	MORN repeat containing 5	2											0						AGGCGCCATGGAGTACACAGG	0.488													36	37					2.13384e-23	2.18883e-23	1	1	0
OR1L8	138881	broad.mit.edu	37	9	125330475	125330475	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:125330475G>A	uc004bmp.1	-	1	282	c.282C>T	c.(280-282)TCC>TCT	p.S94S		NM_001004454	NP_001004454	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3						ACCCAGCATAGGAGATGGTCT	0.463													22	38					0	0	1	0	0
NR5A1	2516	broad.mit.edu	37	9	127262843	127262844	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:127262843_127262844GG>AA	uc004boo.1	-	4	582_583	c.395_396CC>TT	c.(394-396)CCC>CTT	p.P132L		NM_004959	NP_004950	Q13285	STF1_HUMAN	nuclear receptor subfamily 5, group A, member 1	132					cell-cell signaling|male gonad development|positive regulation of transcription from RNA polymerase II promoter|primary sex determination|regulation of steroid biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|phospholipid binding|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding				0						GTGCGGGAGGGGGCGGCGGGGG	0.698													10	28					0	0	1	0	0
GOLGA1	2800	broad.mit.edu	37	9	127700867	127700867	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:127700867C>T	uc004bpc.2	-	3	466	c.124G>A	c.(124-126)GGA>AGA	p.G42R	GOLGA1_uc010mwt.1_Missense_Mutation_p.G42R	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97	42						Golgi cisterna membrane				ovary(1)	1						AAGTCATCTCCTGAGTCAGCT	0.403													17	47					0	0	1	0	0
CDK9	1025	broad.mit.edu	37	9	130551705	130551705	+	Silent	SNP	C	T	T	rs142704308		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:130551705C>T	uc004bse.2	+	7	1125	c.1002C>T	c.(1000-1002)TCC>TCT	p.S334S		NM_001261	NP_001252	P50750	CDK9_HUMAN	cyclin-dependent kinase 9	334					cell proliferation|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	transcription elongation factor complex	ATP binding|cyclin-dependent protein kinase activity|DNA binding|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(1)	1						ACCTGACGTCCATGTTCGAGT	0.632													72	109					0	0	1	0	0
ST6GALNAC4	27090	broad.mit.edu	37	9	130670814	130670814	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:130670814G>A	uc004bss.2	-	6	1042	c.766C>T	c.(766-768)CGG>TGG	p.R256W	ST6GALNAC4_uc004bst.2_Missense_Mutation_p.R172W	NM_175039	NP_778204	Q9H4F1	SIA7D_HUMAN	sialyltransferase 7D isoform a	256	Lumenal (Potential).				glycolipid metabolic process|protein glycosylation	integral to Golgi membrane|nucleus|soluble fraction	(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity				0						TCATCTAGCCGGCCCTTCTCA	0.637													34	50					0	0	1	0	0
NAIF1	203245	broad.mit.edu	37	9	130825874	130825874	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:130825874G>A	uc004bta.2	-	2	1036	c.817C>T	c.(817-819)CAG>TAG	p.Q273*	NAIF1_uc004bsz.2_RNA	NM_197956	NP_931045	Q69YI7	NAIF1_HUMAN	nuclear apoptosis inducing factor 1	273					apoptosis|induction of apoptosis	nucleus					0						TCCATGGCCTGGGCCTGGCGC	0.612													18	24					0	0	1	0	0
SLC25A25	114789	broad.mit.edu	37	9	130854363	130854363	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:130854363C>T	uc004btd.2	+	1	236	c.214C>T	c.(214-216)CCT>TCT	p.P72S	SLC25A25_uc004btb.2_Intron|SLC25A25_uc004btc.2_Missense_Mutation_p.P72S	NM_001006642	NP_001006643	Q6KCM7	SCMC2_HUMAN	solute carrier family 25, member 25 isoform c	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding				0						AGAGCAGTTTCCTAAGGTAAT	0.522													16	22					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137676837	137676837	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:137676837G>A	uc004cfe.2	+	30	2869	c.2487G>A	c.(2485-2487)GGG>GGA	p.G829G		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	829	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GCTTGCAGGGGGAGATCGGCC	0.637													7	32					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137734005	137734005	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:137734005C>T	uc004cfe.2	+	66	5755	c.5373C>T	c.(5371-5373)ACC>ACT	p.T1791T	uc004cff.2_Intron	NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1791	Fibrillar collagen NC1.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TTCCCCAGACCAAGAAAGGCT	0.547													19	43					0	0	1	0	0
NACC2	138151	broad.mit.edu	37	9	138908222	138908222	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:138908222G>A	uc004cgw.2	-	3	1096	c.940C>T	c.(940-942)CGC>TGC	p.R314C	NACC2_uc010nbh.2_5'UTR	NM_144653	NP_653254	Q96BF6	NACC2_HUMAN	BTB (POZ) domain containing 14A	314					negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization	nuclear body					0						AGGTCGCGGCGGATGAGGACG	0.662													52	61					0	0	1	0	0
ENTPD8	377841	broad.mit.edu	37	9	140331055	140331055	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:140331055G>A	uc004cmw.2	-	6	888	c.704C>T	c.(703-705)TCC>TTC	p.S235F	C9orf167_uc011mew.1_Intron|ENTPD8_uc004cmx.2_Missense_Mutation_p.S235F|ENTPD8_uc004cmy.2_3'UTR	NM_001033113	NP_001028285	Q5MY95	ENTP8_HUMAN	ectonucleoside triphosphate diphosphohydrolase 8	235	Extracellular (Potential).					integral to membrane|plasma membrane	ATP binding			skin(1)	1	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000224)|Epithelial(140;0.000898)		GCTGTAGTCGGAGCCGTAGAG	0.637													6	9					0	0	1	0	0
FRMPD4	9758	broad.mit.edu	37	X	12734245	12734245	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:12734245A>T	uc004cuz.1	+	15	2173	c.1667A>T	c.(1666-1668)CAA>CTA	p.Q556L	FRMPD4_uc011mij.1_Missense_Mutation_p.Q548L	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	556					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						TGTATACCCCAAATGACCACC	0.453													84	13					0	0	1	0	0
CNKSR2	22866	broad.mit.edu	37	X	21549990	21549990	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:21549990C>T	uc004czx.1	+	11	1144	c.1108C>T	c.(1108-1110)CTT>TTT	p.L370F	CNKSR2_uc004czw.2_Missense_Mutation_p.L370F|CNKSR2_uc011mjn.1_Missense_Mutation_p.L321F|CNKSR2_uc011mjo.1_Missense_Mutation_p.L370F|CNKSR2_uc004czy.2_5'UTR	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	370	DUF1170.				regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						AAAAGGAAACCTTCCTTGTGA	0.388													9	2					0	0	1	0	0
CXorf58	254158	broad.mit.edu	37	X	23953394	23953394	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:23953394C>T	uc004daz.1	+	7	981	c.637C>T	c.(637-639)CCC>TCC	p.P213S	CXorf58_uc011mju.1_Missense_Mutation_p.P213S	NM_152761	NP_689974	Q96LI9	CX058_HUMAN	hypothetical protein LOC254158	213											0						TGAAAATATTCCCAGGACAAT	0.398													37	7					0	0	1	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27999214	27999214	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:27999214C>T	uc004dbx.1	-	1	353	c.238G>A	c.(238-240)GAA>AAA	p.E80K		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	80	Glu-rich.									ovary(3)|skin(1)	4						CTTTCAAGTTCGACGTCTTCA	0.378													67	8					0	0	1	0	0
MAGEB3	4114	broad.mit.edu	37	X	30254876	30254876	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:30254876G>A	uc004dca.1	+	5	1572	c.835G>A	c.(835-837)GCC>ACC	p.A279T		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	279	MAGE.										0						GGGTCCAAGAGCCCATGCTGA	0.488													36	5					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37026648	37026648	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:37026648G>A	uc004ddl.1	+	1	179	c.165G>A	c.(163-165)ATG>ATA	p.M55I		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	55										ovary(3)	3						CGGAGGGCATGGACGACTTCC	0.557													21	2					0	0	1	0	0
RPGR	6103	broad.mit.edu	37	X	38150211	38150212	+	Splice_Site	DNP	CC	TT	TT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:38150211_38150212CC>TT	uc004ded.1	-	13	1740	c.1572_splice	c.e13+1	p.K524_splice	RPGR_uc004deb.2_Splice_Site_p.K524_splice|RPGR_uc004dea.2_Splice_Site|RPGR_uc004dec.2_Splice_Site	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C						intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						TCATATTATACCTTTTGTTTCT	0.267													11	5					0	0	1	0	0
USP9X	8239	broad.mit.edu	37	X	40982966	40982966	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:40982966C>T	uc004dfb.2	+	2	718	c.85C>T	c.(85-87)CAA>TAA	p.Q29*	USP9X_uc004dfc.2_Nonsense_Mutation_p.Q29*	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	29					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						GCCCCCCCTCCAACAGAATCA	0.413													3	15					0	0	1	0	0
DDX3X	1654	broad.mit.edu	37	X	41203369	41203370	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:41203369_41203370GG>AA	uc004dfe.2	+	9	1707_1708	c.852_853GG>AA	c.(850-855)GAGGAA>GAAAAA	p.E285K	DDX3X_uc010nhf.1_Missense_Mutation_p.E269K|DDX3X_uc004dff.2_Missense_Mutation_p.E285K|DDX3X_uc011mkq.1_Missense_Mutation_p.E269K|DDX3X_uc011mkr.1_Missense_Mutation_p.E285K|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_RNA|DDX3X_uc011mkt.1_RNA	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	285	Necessary for interaction with XPO1.|Helicase ATP-binding.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						AGATCTACGAGGAAGCCAGAAA	0.361										HNSCC(61;0.18)			11	0					0	0	1	0	0
ZNF157	7712	broad.mit.edu	37	X	47272113	47272113	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:47272113G>A	uc004dhr.1	+	4	710	c.641G>A	c.(640-642)GGG>GAG	p.G214E		NM_003446	NP_003437	P51786	ZN157_HUMAN	zinc finger protein 157	214					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						ACTCACACAGGGGAGAGGCCC	0.443													22	6					0	0	1	0	0
KCND1	3750	broad.mit.edu	37	X	48826487	48826487	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:48826487G>A	uc004dlx.1	-	1	1765	c.192C>T	c.(190-192)ACC>ACT	p.T64T	KCND1_uc004dlw.1_5'Flank	NM_004979	NP_004970	Q9NSA2	KCND1_HUMAN	potassium voltage-gated channel, Shal-related	64	Cytoplasmic (Potential).					voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			ovary(2)|lung(1)	3						TGCCCAGCAAGGTGTCTGGGT	0.562													4	13					0	0	1	0	0
SHROOM4	57477	broad.mit.edu	37	X	50351074	50351074	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:50351074A>T	uc004dpe.2	-	6	3094	c.3068T>A	c.(3067-3069)CTC>CAC	p.L1023H	SHROOM4_uc004dpd.3_RNA	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	1023					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					GTCTCCAAGGAGGTCAAGAGA	0.502													11	2					0	0	1	0	0
ERCC6L	54821	broad.mit.edu	37	X	71427432	71427432	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:71427432C>T	uc004eaq.1	-	2	1282	c.1185G>A	c.(1183-1185)ATG>ATA	p.M395I	PIN4_uc004eao.1_Intron|ERCC6L_uc004eap.1_Missense_Mutation_p.M272I	NM_017669	NP_060139	Q2NKX8	ERC6L_HUMAN	excision repair protein ERCC6-like	395					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			ovary(3)	3	Renal(35;0.156)					AGCGCGTCTCCATTAGCAACT	0.413													4	31					0	0	1	0	0
RPS6KA6	27330	broad.mit.edu	37	X	83351312	83351312	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:83351312G>A	uc004eej.1	-	20	1938	c.1861C>T	c.(1861-1863)CCA>TCA	p.P621S	RPS6KA6_uc011mqt.1_Missense_Mutation_p.P621S|RPS6KA6_uc011mqu.1_Missense_Mutation_p.P518S	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	621	Protein kinase 2.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						TTAGCAAATGGAGTGTAGCTA	0.343													12	2					0	0	1	0	0
ZNF711	7552	broad.mit.edu	37	X	84526400	84526400	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:84526400C>T	uc004eeo.2	+	9	2199	c.1852C>T	c.(1852-1854)CCT>TCT	p.P618S	ZNF711_uc004eep.2_Missense_Mutation_p.P618S|ZNF711_uc004eeq.2_Missense_Mutation_p.P664S|ZNF711_uc011mqy.1_Missense_Mutation_p.P217S	NM_021998	NP_068838	Q9Y462	ZN711_HUMAN	zinc finger protein 711	618					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			ovary(3)|skin(1)	4						TAAGGATTTTCCTCACAAATG	0.423													4	1					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91091009	91091009	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:91091009G>A	uc004efk.1	+	1	1351	c.506G>A	c.(505-507)GGA>GAA	p.G169E	PCDH11X_uc004efl.1_Missense_Mutation_p.G169E|PCDH11X_uc004efo.1_Missense_Mutation_p.G169E|PCDH11X_uc010nmv.1_Missense_Mutation_p.G169E|PCDH11X_uc004efm.1_Missense_Mutation_p.G169E|PCDH11X_uc004efn.1_Missense_Mutation_p.G169E|PCDH11X_uc004efh.1_Missense_Mutation_p.G169E|PCDH11X_uc004efj.1_Missense_Mutation_p.G169E	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	169	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CCTGACGTAGGAATAAACGGA	0.343													25	2					0	0	1	0	0
LOC643486	643486	broad.mit.edu	37	X	95592418	95592418	+	RNA	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:95592418C>T	uc010nmx.2	-	1		c.484G>A				NR_003539				Homo sapiens cDNA FLJ42288 fis, clone TLIVE2006236.												0						TGCTCTTCTCCATAGCACTTG	0.368													5	1					0	0	1	0	0
TNMD	64102	broad.mit.edu	37	X	99849315	99849315	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:99849315A>G	uc004efy.3	+	4	605	c.379A>G	c.(379-381)AAA>GAA	p.K127E	TNMD_uc004efz.2_Missense_Mutation_p.K127E	NM_022144	NP_071427	Q9H2S6	TNMD_HUMAN	tenomodulin	127	Extracellular (Potential).|BRICHOS.					integral to membrane				central_nervous_system(1)	1						AACTCAGATTAAAGTGATTCC	0.313													20	3					0	0	1	0	0
SYTL4	94121	broad.mit.edu	37	X	99956510	99956510	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:99956510G>A	uc004egd.3	-	5	626	c.270C>T	c.(268-270)GAC>GAT	p.D90D	SYTL4_uc010nnc.2_Silent_p.D90D|SYTL4_uc004ege.3_Silent_p.D90D|SYTL4_uc004egf.3_Silent_p.D90D|SYTL4_uc004egg.3_Silent_p.D90D	NM_080737	NP_542775	Q96C24	SYTL4_HUMAN	synaptotagmin-like 4	90	RabBD.|FYVE-type.				exocytosis|intracellular protein transport	extrinsic to membrane|plasma membrane|synaptic vesicle|transport vesicle membrane	neurexin binding|phospholipid binding|Rab GTPase binding|transporter activity|zinc ion binding			ovary(2)	2					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GTATGCGGCAGTCCCGACACA	0.572													16	76					0	0	1	0	0
NXF3	56000	broad.mit.edu	37	X	102337762	102337762	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:102337762C>T	uc004eju.2	-	8	777	c.706G>A	c.(706-708)GAT>AAT	p.D236N	NXF3_uc010noi.1_Missense_Mutation_p.D86N|NXF3_uc011mrw.1_Missense_Mutation_p.D236N|NXF3_uc011mrx.1_Missense_Mutation_p.D147N	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	236						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						ATCTTAGTATCACGGTTCACC	0.522													63	9					0	0	1	0	0
MUM1L1	139221	broad.mit.edu	37	X	105450359	105450359	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:105450359A>C	uc004emf.1	+	4	1583	c.934A>C	c.(934-936)AGT>CGT	p.S312R	MUM1L1_uc004emg.1_Missense_Mutation_p.S312R	NM_152423	NP_689636	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	312										ovary(2)|pancreas(1)|skin(1)	4						ATGCCCTGGGAGTTGTTCAAG	0.458													6	3					0	0	1	0	0
HTR2C	3358	broad.mit.edu	37	X	114141464	114141464	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:114141464G>A	uc004epu.1	+	6	1591	c.863G>A	c.(862-864)CGA>CAA	p.R288Q	HTR2C_uc010nqc.1_Missense_Mutation_p.R288Q|HTR2C_uc004epv.1_3'UTR	NM_000868	NP_000859	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C	288	Cytoplasmic (By similarity).				cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			ovary(3)	3					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	AACGCACGCCGAAGAAAGAAG	0.488													23	3					0	0	1	0	0
DOCK11	139818	broad.mit.edu	37	X	117786037	117786037	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:117786037G>A	uc004eqp.2	+	42	4755	c.4692G>A	c.(4690-4692)ATG>ATA	p.M1564I	DOCK11_uc004eqq.2_Missense_Mutation_p.M1343I	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1564	DHR-2.				blood coagulation	cytosol	GTP binding			ovary(3)	3						ACAGACCTATGAAGGTATGTT	0.343													19	0					0	0	1	0	0
LONRF3	79836	broad.mit.edu	37	X	118109231	118109231	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:118109231G>A	uc004eqw.2	+	1	519	c.488G>A	c.(487-489)GGG>GAG	p.G163E	LONRF3_uc004eqx.2_Missense_Mutation_p.G163E|LONRF3_uc004eqy.2_RNA|LONRF3_uc004eqz.2_5'Flank	NM_001031855	NP_001027026	Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger	163	RING-type 1.				proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)	2						AAATGTCATGGGTTTCTATCA	0.672													15	2					0	0	1	0	0
KIAA1210	57481	broad.mit.edu	37	X	118242361	118242361	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:118242361C>T	uc004era.3	-	6	851	c.851G>A	c.(850-852)GGA>GAA	p.G284E		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	284										ovary(4)|skin(1)	5						AAGCACAGCTCCTGACATGGC	0.393													66	10					0	0	1	0	0
OCRL	4952	broad.mit.edu	37	X	128674731	128674731	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:128674731G>A	uc004euq.2	+	2	215	c.50G>A	c.(49-51)GGT>GAT	p.G17D	OCRL_uc004eur.2_Missense_Mutation_p.G17D	NM_000276	NP_000267	Q01968	OCRL_HUMAN	phosphatidylinositol polyphosphate 5-phosphatase	17					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			lung(2)|ovary(1)|kidney(1)	4						ACTGTCGAGGGTATGGAGATG	0.592													51	11					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130417205	130417205	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:130417205G>A	uc004ewd.2	-	6	939	c.701C>T	c.(700-702)CCT>CTT	p.P234L	IGSF1_uc004ewe.3_Missense_Mutation_p.P223L|IGSF1_uc004ewf.2_Missense_Mutation_p.P214L	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	234	Ig-like C2-type 3.|Extracellular (Potential).				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						GATGGGCCCAGGATGGGCTGT	0.478													15	7					0	0	1	0	0
ZNF75D	7626	broad.mit.edu	37	X	134421469	134421469	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:134421469G>A	uc004eyp.2	-	7	3788	c.1133C>T	c.(1132-1134)TCT>TTT	p.S378F	ZNF75D_uc004eym.2_Intron|ZNF75D_uc004eyn.2_Missense_Mutation_p.S157F|ZNF75D_uc004eyo.2_Missense_Mutation_p.S283F	NM_007131	NP_009062	P51815	ZN75D_HUMAN	zinc finger protein 75	378	C2H2-type 1.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AATAAGATCAGAGCTAACTCT	0.408													19	2					0	0	1	0	0
SAGE1	55511	broad.mit.edu	37	X	134989114	134989114	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:134989114G>A	uc004ezh.2	+	8	933	c.766G>A	c.(766-768)GAG>AAG	p.E256K	SAGE1_uc010nry.1_Missense_Mutation_p.E225K|SAGE1_uc011mvv.1_Intron	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	256										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					TGTCCCTGAGGAGAAGATGGA	0.473													55	6					0	0	1	0	0
HTATSF1	27336	broad.mit.edu	37	X	135581896	135581896	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:135581896C>T	uc004ezw.2	+	3	748	c.326C>T	c.(325-327)ACT>ATT	p.T109I	HTATSF1_uc004ezx.2_Missense_Mutation_p.T109I	NM_001163280	NP_001156752	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	109					regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CCGGAACCCACTGATGCCAGA	0.433													22	3					0	0	1	0	0
FGF13	2258	broad.mit.edu	37	X	137715022	137715022	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:137715022C>T	uc004fam.2	-	5	1389	c.727G>A	c.(727-729)GAA>AAA	p.E243K	FGF13_uc004fan.2_Missense_Mutation_p.E190K|FGF13_uc011mwi.1_Missense_Mutation_p.E224K|FGF13_uc004faq.2_Missense_Mutation_p.E253K|FGF13_uc004far.2_Missense_Mutation_p.E224K|FGF13_uc011mwj.1_Missense_Mutation_p.E253K|FGF13_uc011mwk.1_Missense_Mutation_p.E197K	NM_004114	NP_004105	Q92913	FGF13_HUMAN	fibroblast growth factor 13 isoform 1	243					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					TACGTTGATTCATTGTGGCTC	0.517													75	9					0	0	1	0	0
F9	2158	broad.mit.edu	37	X	138643952	138643952	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:138643952C>T	uc004fas.1	+	8	1137	c.1108C>T	c.(1108-1110)CAG>TAG	p.Q370*	F9_uc004fat.1_Nonsense_Mutation_p.Q332*	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	370	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	TTTAGTTCTTCAGTACCTTAG	0.448													33	5					0	0	1	0	0
F9	2158	broad.mit.edu	37	X	138644072	138644072	+	Missense_Mutation	SNP	G	A	A	rs137852278		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:138644072G>A	uc004fas.1	+	8	1257	c.1228G>A	c.(1228-1230)GAT>AAT	p.D410N	F9_uc004fat.1_Missense_Mutation_p.D372N	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	410	Peptidase S1.		D -> H (in HEMB; Mechtal).		blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	ATGTCAAGGAGATAGTGGGGG	0.443													47	2					0	0	1	0	0
MAGEC3	139081	broad.mit.edu	37	X	140985056	140985056	+	Silent	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:140985056C>T	uc011mwp.1	+	7	1512	c.1512C>T	c.(1510-1512)TTC>TTT	p.F504F	MAGEC3_uc004fbs.2_Silent_p.F206F|MAGEC3_uc010nsj.2_Silent_p.F206F	NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	504	MAGE 2.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CCCATGAGTTCATAGAGCTAA	0.443													60	10					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140993876	140993876	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:140993876C>T	uc004fbt.2	+	4	972	c.686C>T	c.(685-687)GCC>GTC	p.A229V	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	229							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GAGGGTTTTGCCCAGTCTCCT	0.488										HNSCC(15;0.026)			62	9					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995477	140995477	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:140995477C>T	uc004fbt.2	+	4	2573	c.2287C>T	c.(2287-2289)CCT>TCT	p.P763S	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	763							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CCCTGAGAGTCCTCAGAGTCC	0.542										HNSCC(15;0.026)			95	13					0	0	1	0	0
MIR513A2	574510	broad.mit.edu	37	X	146307386	146307386	+	RNA	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:146307386G>A	hsa-mir-513a-2|MI0003192	-			c.85G>A																				0						acccttctcagaaaggtgaaa	0.194													25	2					0	0	1	0	0
MAGEA11	4110	broad.mit.edu	37	X	148798152	148798152	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:148798152G>A	uc004fdq.2	+	5	1108	c.1006G>A	c.(1006-1008)GAA>AAA	p.E336K	HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|MAGEA11_uc004fdr.2_Missense_Mutation_p.E307K	NM_005366	NP_005357	P43364	MAGAB_HUMAN	melanoma antigen family A, 11 isoform a	336	MAGE.					cytoplasm|nucleus	protein binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					GGTTATGTGGGAAGTCCTGAG	0.512													26	90					0	0	1	0	0
CNGA2	1260	broad.mit.edu	37	X	150912691	150912691	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:150912691G>A	uc004fey.1	+	7	1940	c.1716G>A	c.(1714-1716)GAG>GAA	p.E572E		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	572	cAMP (By similarity).|Cytoplasmic (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTAGAAGAGAGGGGTCGGG	0.537													59	9					0	0	1	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900372	151900372	+	Silent	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:151900372G>A	uc010ntp.2	-	3	783	c.429C>T	c.(427-429)TTC>TTT	p.F143F	MAGEA12_uc004fgb.2_Intron|MAGEA12_uc004fgc.2_Silent_p.F143F|CSAG1_uc004fge.2_5'Flank|CSAG1_uc004fgf.2_5'Flank|CSAG1_uc004fgd.2_5'Flank	NM_005367	NP_005358	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	143	MAGE.									skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					AGAAGTCCTGGAAATTTCTGA	0.507													75	8					0	0	1	0	0
PNMA5	114824	broad.mit.edu	37	X	152159755	152159755	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:152159755G>A	uc010ntw.2	-	3	727	c.388C>T	c.(388-390)CCT>TCT	p.P130S	PNMA5_uc004fha.3_Missense_Mutation_p.P130S|PNMA5_uc010ntx.2_Missense_Mutation_p.P130S|PNMA5_uc004fgy.3_Missense_Mutation_p.P130S	NM_001103151	NP_001096621	Q96PV4	PNMA5_HUMAN	paraneoplastic antigen like 5	130					apoptosis					ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					ctctcggcagggaggctgcaa	0.194													111	11					0	0	1	0	0
SLC10A3	8273	broad.mit.edu	37	X	153716816	153716816	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chrX:153716816G>A	uc004flq.2	-	3	728	c.464C>T	c.(463-465)GCC>GTC	p.A155V	UBL4A_uc004flo.2_5'Flank|SLC10A3_uc004flr.2_Missense_Mutation_p.A126V|SLC10A3_uc004flp.2_Missense_Mutation_p.A155V	NM_001142392	NP_001135864	P09131	P3_HUMAN	solute carrier family 10, member 3 isoform 1	155					organic anion transport	integral to membrane	bile acid:sodium symporter activity			ovary(1)|skin(1)	2	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGTGGGCGGGGCCTCATGGGC	0.647													49	13					0	0	1	0	0
ITGA10	8515	broad.mit.edu	37	1	145534121	145534122	+	Frame_Shift_Ins	INS	-	C	C	rs147270843		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr1:145534121_145534122insC	uc001eoa.2	+	14	1702_1703	c.1626_1627insC	c.(1624-1629)GAACCCfs	p.E542fs	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Frame_Shift_Ins_p.E411fs|ITGA10_uc009wiw.2_Frame_Shift_Ins_p.E399fs|ITGA10_uc010oyw.1_Frame_Shift_Ins_p.E487fs	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	542_543	Extracellular (Potential).|FG-GAP 6.				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTCAGCCAGAACCCCCCCAGGA	0.554													14	268	---	---	---	---					
COL17A1	1308	broad.mit.edu	37	10	105800146	105800147	+	Frame_Shift_Ins	INS	-	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr10:105800146_105800147insG	uc001kxr.2	-	40	2892_2893	c.2723_2724insC	c.(2722-2724)CCAfs	p.P908fs		NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	908	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		CAGGTGGGCCTGGGGGGCCGGA	0.470													45	99	---	---	---	---					
FNBP4	23360	broad.mit.edu	37	11	47788664	47788669	+	In_Frame_Del	DEL	GGTGGT	-	-	rs59413596		TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr11:47788664_47788669delGGTGGT	uc009ylv.2	-	1	325_330	c.172_177delACCACC	c.(172-177)ACCACCdel	p.TT58del	FNBP4_uc001ngj.2_5'UTR|FNBP4_uc001ngl.2_RNA	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	58_59										ovary(1)	1						CAGTCACCGCGGTGGTGGTGGTCGTC	0.748													2	4	---	---	---	---					
ACRBP	84519	broad.mit.edu	37	12	6754500	6754501	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr12:6754500_6754501delCT	uc001qpu.1	-	4	408_409	c.360_361delAG	c.(358-363)AGAGTCfs	p.R120fs	ACRBP_uc010sfg.1_Frame_Shift_Del_p.R120fs	NM_032489	NP_115878	Q8NEB7	ACRBP_HUMAN	proacrosin binding protein sp32 precursor	120_121						acrosomal vesicle|extracellular region				central_nervous_system(1)	1						GAACACAGGACTCTCTGCAGGA	0.500													10	48	---	---	---	---					
MYO1E	4643	broad.mit.edu	37	15	59466410	59466411	+	Frame_Shift_Del	DEL	TC	-	-			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr15:59466410_59466411delTC	uc002aga.2	-	20	2450_2451	c.2078_2079delGA	c.(2077-2079)AGAfs	p.R693fs	MIR2116_hsa-mir-2116|MI0010635_5'Flank	NM_004998	NP_004989	Q12965	MYO1E_HUMAN	myosin IE	693					actin filament-based movement	myosin complex	actin binding|ATP binding|ATPase activity, coupled|calmodulin binding|microfilament motor activity			central_nervous_system(3)	3				all cancers(107;0.207)		CATCATACTTTCTCTCTCTCAT	0.406													11	169	---	---	---	---					
TSC2	7249	broad.mit.edu	37	16	2136326	2136327	+	Frame_Shift_Del	DEL	GT	-	-			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:2136326_2136327delGT	uc002con.2	+	37	4901_4902	c.4795_4796delGT	c.(4795-4797)GTGfs	p.V1599fs	TSC2_uc010bsd.2_Frame_Shift_Del_p.V1576fs|TSC2_uc002coo.2_Frame_Shift_Del_p.V1532fs|TSC2_uc010uvv.1_Frame_Shift_Del_p.V1496fs|TSC2_uc010uvw.1_Frame_Shift_Del_p.V1484fs|TSC2_uc002cop.2_Frame_Shift_Del_p.V1355fs|TSC2_uc002coq.2_Frame_Shift_Del_p.V374fs|TSC2_uc002cor.2_Frame_Shift_Del_p.V300fs	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	1599	Rap-GAP.				cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				AGGCCTGGACGTGTGTGGTGAG	0.649			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				12	67	---	---	---	---					
FBRS	64319	broad.mit.edu	37	16	30678904	30678904	+	Frame_Shift_Del	DEL	G	-	-			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr16:30678904delG	uc002dzd.3	+	9	738	c.475delG	c.(475-477)GGGfs	p.G159fs	FBRS_uc002dzc.3_Frame_Shift_Del_p.G71fs	NM_001105079	NP_001098549	Q9HAH7	FBRS_HUMAN	fibrosin	159										ovary(1)	1			Colorectal(24;0.103)			GGCAGCTCCCGGGGCCCACGG	0.632													2	4	---	---	---	---					
EVPL	2125	broad.mit.edu	37	17	74003457	74003457	+	Frame_Shift_Del	DEL	C	-	-			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr17:74003457delC	uc002jqi.2	-	22	6057	c.5829delG	c.(5827-5829)GGGfs	p.G1943fs	EVPL_uc010wss.1_Frame_Shift_Del_p.G1965fs|EVPL_uc010wst.1_Frame_Shift_Del_p.G1413fs	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	1943	Plectin 6.|Globular 2.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						GGTCGATGAGCCCCCCGGTCA	0.667													20	22	---	---	---	---					
C19orf57	79173	broad.mit.edu	37	19	14003610	14003611	+	In_Frame_Ins	INS	-	CCCACT	CCCACT			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:14003610_14003611insCCCACT	uc002mxl.1	-	5	440_441	c.381_382insAGTGGG	c.(379-384)insAGTGGG	p.127_128insSG	C19orf57_uc002mxk.1_In_Frame_Ins_p.9_10insSG|C19orf57_uc002mxm.1_In_Frame_Ins_p.127_128insSG	NM_024323	NP_077299	Q0VDD7	CS057_HUMAN	hypothetical protein LOC79173	127_128					multicellular organismal development		protein binding			ovary(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			AGGCTAAAGGCCCCACTCCCAC	0.540													10	44	---	---	---	---					
NUDT19	390916	broad.mit.edu	37	19	33182995	33182997	+	In_Frame_Del	DEL	GCT	-	-			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr19:33182995_33182997delGCT	uc010edf.2	+	1	129_131	c.129_131delGCT	c.(127-132)CGGCTG>CGG	p.L47del		NM_001105570	NP_001099040	A8MXV4	NUD19_HUMAN	nudix (nucleoside diphosphate linked moiety	47	Nudix hydrolase.					mitochondrion|peroxisome	hydrolase activity|metal ion binding				0	Esophageal squamous(110;0.137)					AGGGCTTCCGGCTGCTGCTGCTG	0.783													2	4	---	---	---	---					
ROCK2	9475	broad.mit.edu	37	2	11389836	11389837	+	Frame_Shift_Ins	INS	-	A	A			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:11389836_11389837insA	uc002rbd.1	-	4	861_862	c.412_413insT	c.(412-414)TGGfs	p.W138fs		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	138	Protein kinase.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity	p.W138fs*31(1)		stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		TCTTTCTTCCCAAAAAAAGGCA	0.356													15	79	---	---	---	---					
STRN	6801	broad.mit.edu	37	2	37105142	37105144	+	In_Frame_Del	DEL	AGA	-	-			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr2:37105142_37105144delAGA	uc002rpn.2	-	10	1222_1224	c.1213_1215delTCT	c.(1213-1215)TCTdel	p.S405del	STRN_uc010ezx.2_In_Frame_Del_p.S368del	NM_003162	NP_003153	O43815	STRN_HUMAN	striatin, calmodulin binding protein	405					dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			skin(1)	1		Ovarian(717;0.0129)|all_hematologic(82;0.21)				ATGACTTTCCAGAAGAAGGAGGA	0.433													63	193	---	---	---	---					
MYH9	4627	broad.mit.edu	37	22	36696948	36696950	+	In_Frame_Del	DEL	CTC	-	-			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr22:36696948_36696950delCTC	uc003apg.2	-	22	3016_3018	c.2785_2787delGAG	c.(2785-2787)GAGdel	p.E929del	MYH9_uc003aph.1_In_Frame_Del_p.E793del	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	929	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						GCTGGCAGCGCTCCTCCTCCTCC	0.665			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				12	251	---	---	---	---					
SEC31A	22872	broad.mit.edu	37	4	83795800	83795801	+	Frame_Shift_Ins	INS	-	T	T			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr4:83795800_83795801insT	uc003hnf.2	-	6	766_767	c.602_603insA	c.(601-603)AATfs	p.N201fs	SEC31A_uc003hne.2_5'Flank|SEC31A_uc011ccl.1_Frame_Shift_Ins_p.N201fs|SEC31A_uc003hnl.2_Frame_Shift_Ins_p.N201fs|SEC31A_uc003hng.2_Frame_Shift_Ins_p.N201fs|SEC31A_uc003hnh.2_Frame_Shift_Ins_p.N201fs|SEC31A_uc003hni.2_Frame_Shift_Ins_p.N201fs|SEC31A_uc003hnj.2_Frame_Shift_Ins_p.N201fs|SEC31A_uc011ccm.1_Frame_Shift_Ins_p.N196fs|SEC31A_uc011ccn.1_Frame_Shift_Ins_p.N201fs|SEC31A_uc003hnk.2_Frame_Shift_Ins_p.N201fs|SEC31A_uc003hnm.2_Frame_Shift_Ins_p.N201fs|SEC31A_uc003hnn.1_Frame_Shift_Ins_p.N201fs|SEC31A_uc003hno.2_Frame_Shift_Ins_p.N201fs	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	201	WD 3.|Interaction with SEC13.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				TGATTGGCTCATTTTTTCTAAG	0.411													7	147	---	---	---	---					
MGC42105	167359	broad.mit.edu	37	5	43246078	43246078	+	Frame_Shift_Del	DEL	G	-	-			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr5:43246078delG	uc003jno.2	+	2	1082	c.201delG	c.(199-201)CTGfs	p.L67fs		NM_153361	NP_699192	Q8IY84	NIM1_HUMAN	serine/threonine-protein kinase NIM1	67							ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|stomach(1)|large_intestine(1)|breast(1)	9						AGATCACGCTGGGGAAACGGA	0.557													10	95	---	---	---	---					
BAT2	7916	broad.mit.edu	37	6	31594939	31594939	+	Frame_Shift_Del	DEL	C	-	-			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:31594939delC	uc003nvb.3	+	11	1503	c.1254delC	c.(1252-1254)GGCfs	p.G418fs	BAT2_uc011dnv.1_RNA|BAT2_uc003nvc.3_Frame_Shift_Del_p.G418fs	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	418	4 X 57 AA type A repeats.|2 X type B repeats.|2-1.					cytoplasm|nucleus	protein binding				0						CTCACCGGGGCCCCGCCGGGA	0.637													20	46	---	---	---	---					
STK38	11329	broad.mit.edu	37	6	36465583	36465583	+	Frame_Shift_Del	DEL	A	-	-			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:36465583delA	uc003omg.2	-	11	1734	c.1146delT	c.(1144-1146)TTTfs	p.F382fs	STK38_uc003omh.2_Frame_Shift_Del_p.F382fs|STK38_uc003omi.2_Frame_Shift_Del_p.F382fs	NM_007271	NP_009202	Q15208	STK38_HUMAN	serine/threonine kinase 38	382	Protein kinase.				intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6						CAACGCCTTCAAAAAAAGAGT	0.368													15	70	---	---	---	---					
PHF3	23469	broad.mit.edu	37	6	64423251	64423251	+	Frame_Shift_Del	DEL	T	-	-			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr6:64423251delT	uc003pep.1	+	15	5793	c.5767delT	c.(5767-5769)TTTfs	p.F1923fs	PHF3_uc003pen.2_Frame_Shift_Del_p.F1835fs|PHF3_uc011dxs.1_Frame_Shift_Del_p.F1192fs	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1923					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			CCGCCAGAGATTTTATAGTGA	0.408													187	113	---	---	---	---					
IQCE	23288	broad.mit.edu	37	7	2618122	2618122	+	Frame_Shift_Del	DEL	G	-	-			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:2618122delG	uc003smo.3	+	8	776	c.592delG	c.(592-594)GTTfs	p.V198fs	IQCE_uc010ksm.1_Frame_Shift_Del_p.V198fs|IQCE_uc003sml.1_Frame_Shift_Del_p.V198fs|IQCE_uc011jvy.1_Frame_Shift_Del_p.V182fs|IQCE_uc011jvz.1_Frame_Shift_Del_p.V133fs|IQCE_uc003smk.3_Frame_Shift_Del_p.V182fs|IQCE_uc003smn.3_Frame_Shift_Del_p.V133fs	NM_152558	NP_689771	Q6IPM2	IQCE_HUMAN	IQ motif containing E isoform 1	198	Potential.										0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		CACGGATTTTGTTCGGACTCT	0.597													89	115	---	---	---	---					
EPHB6	2051	broad.mit.edu	37	7	142561447	142561448	+	Frame_Shift_Ins	INS	-	G	G			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr7:142561447_142561448insG	uc011kst.1	+	6	946_947	c.159_160insG	c.(157-162)CCAGGGfs	p.P53fs	EPHB6_uc011ksu.1_Frame_Shift_Ins_p.P53fs|EPHB6_uc003wbs.2_Intron|EPHB6_uc003wbt.2_5'UTR|EPHB6_uc003wbu.2_Intron	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	53_54	Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					CCTACCCACCAGGGGGGGTGAG	0.574													26	203	---	---	---	---					
ZFHX4	79776	broad.mit.edu	37	8	77617337	77617337	+	Frame_Shift_Del	DEL	A	-	-			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr8:77617337delA	uc003yav.2	+	2	1401	c.1014delA	c.(1012-1014)CCAfs	p.P338fs	ZFHX4_uc003yat.1_Frame_Shift_Del_p.P338fs|ZFHX4_uc003yau.1_Frame_Shift_Del_p.P338fs|ZFHX4_uc003yaw.1_Frame_Shift_Del_p.P338fs	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	338						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTCTGGAACCAAAAAAATCCA	0.428										HNSCC(33;0.089)			15	105	---	---	---	---					
FAM75A6	389730	broad.mit.edu	37	9	43627338	43627347	+	Frame_Shift_Del	DEL	ATTTCATTGA	-	-			TCGA-EE-A3J7-06A-11D-A20D-08	TCGA-EE-A3J7-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c81f48f-8333-44f7-90cf-54aa2d2415f3	36054c7f-2559-4483-866d-b338e37e7123	g.chr9:43627338_43627347delATTTCATTGA	uc011lrb.1	-	4	1369_1378	c.1340_1349delTCAATGAAAT	c.(1339-1350)TTCAATGAAATGfs	p.F447fs		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	447_450						integral to membrane					0						GACATTGGACATTTCATTGAACAAGAAAGG	0.529													40	45	---	---	---	---					
