Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MTOR	2475	broad.mit.edu	37	1	11272938	11272938	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr1:11272938C>T	uc001asd.2	-	22	3434	c.3313G>A	c.(3313-3315)GCC>ACC	p.A1105T		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	1105	HEAT 5.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity	p.A1105T(1)		central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						TCCAGGTTGGCGCCAAACAGC	0.512000													13	42					0	0	0.001368	0	0
IPO13	9670	broad.mit.edu	37	1	44432250	44432250	+	Silent	SNP	C	T	T			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr1:44432250C>T	uc001ckx.2	+	16	3196	c.2401C>T	c.(2401-2403)CTG>TTG	p.L801L	IPO13_uc001cky.2_Silent_p.L19L	NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	801	HEAT 14.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				CCTGCAGGCTCTGAAGCGGAA	0.607000													21	63					0	0	0.002299	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	Missense_Mutation	SNP	A	G	G	rs2257765		TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr10:38654432A>G	uc010qex.1	+	5	599	c.524A>G	c.(523-525)AAT>AGT	p.N175S	HSD17B7P2_uc001izq.2_RNA|HSD17B7P2_uc001izo.1_RNA|HSD17B7P2_uc001izp.1_Missense_Mutation_p.N173S					SubName: Full=cDNA FLJ60462, highly similar to 3-keto-steroid reductase (EC 1.1.1.270);												0						TCATCTCGCAATGCAAGGAAA	0.453000													3	18					0	0	0.004672	0	0
LOC650623	650623	broad.mit.edu	37	10	81443087	81443087	+	RNA	SNP	C	A	A			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr10:81443087C>A	uc010qlu.1	+	1		c.357C>A				NR_027512				Homo sapiens BEN domain containing 3 pseudogene (LOC650623), non-coding RNA.												0						ATGGCATCTCCCACAAGGTCA	0.587000													5	66					7.48243e-07	1.23044e-06	0.006214	1	0
LOC650623	650623	broad.mit.edu	37	10	81443120	81443120	+	RNA	SNP	G	A	A	rs141959862	by1000genomes	TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr10:81443120G>A	uc010qlu.1	+	1		c.390G>A				NR_027512				Homo sapiens BEN domain containing 3 pseudogene (LOC650623), non-coding RNA.												0						ACCCTCCCTCGGGGGACCTGC	0.557000													5	55					0	0	0.001168	0	0
DCHS1	8642	broad.mit.edu	37	11	6654044	6654044	+	Missense_Mutation	SNP	G	A	A	rs150889229		TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr11:6654044G>A	uc001mem.1	-	6	3109	c.2699C>T	c.(2698-2700)ACG>ATG	p.T900M		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	900	Cadherin 9.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAGCAATACCGTGTCTTCAGG	0.572000													4	29					0	0	0.000248	0	0
STK33	65975	broad.mit.edu	37	11	8435127	8435127	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr11:8435127G>T	uc001mgi.1	-	11	2178	c.1259C>A	c.(1258-1260)TCC>TAC	p.S420Y	STK33_uc001mgj.1_Missense_Mutation_p.S420Y|STK33_uc001mgk.1_Missense_Mutation_p.S420Y|STK33_uc010rbn.1_Missense_Mutation_p.S379Y|STK33_uc001mgl.3_Missense_Mutation_p.S233Y	NM_030906	NP_112168	Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	420						Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|pancreas(1)|central_nervous_system(1)|skin(1)	7				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		TTCTTCAGTGGACGGCTTATT	0.403000													16	54					1.52009e-12	2.61597e-12	0.003163	1	0
Unknown	0	broad.mit.edu	37	11	31086649	31086649	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr11:31086649C>T	uc009yjk.1	-	7	763	c.694G>A	c.(694-696)GAT>AAT	p.D232N	uc009yjl.1_Missense_Mutation_p.D160N|DCDC1_uc001msu.1_Missense_Mutation_p.D403N					RecName: Full=Doublecortin domain-containing protein 5;																		TGGGTCACATCTACTTGTGCA	0.438000													5	10					0	0	0.000602	0	0
ACAD10	80724	broad.mit.edu	37	12	112153653	112153653	+	Silent	SNP	C	T	T			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr12:112153653C>T	uc001tsq.2	+	7	1079	c.879C>T	c.(877-879)CAC>CAT	p.H293H	ACAD10_uc001tso.3_Intron|ACAD10_uc001tsp.2_Silent_p.H293H|ACAD10_uc009zvx.2_Silent_p.H324H|ACAD10_uc001tsr.2_Silent_p.H31H|ACAD10_uc001tss.1_RNA	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	293							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						AGTTTGATCACGGGCAGTCAA	0.473000													33	109					0	0	0.002445	0	0
LOC284232	284232	broad.mit.edu	37	13	19419995	19419995	+	RNA	SNP	C	G	G	rs78291036	by1000genomes	TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr13:19419995C>G	uc010tcj.1	-	1		c.26115G>C				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						GAACTAAGAACAGTTAGATAA	0.294000													4	21					0	0	0.000248	0	0
CLEC14A	161198	broad.mit.edu	37	14	38723898	38723898	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr14:38723898C>T	uc001wum.1	-	1	1677	c.1330G>A	c.(1330-1332)GAG>AAG	p.E444K		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	444	Cytoplasmic (Potential).					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		GGATCACTCTCCAGGCCCGGC	0.582000													21	49					0	0	0.001882	0	0
ADAM6	8755	broad.mit.edu	37	14	106829984	106829985	+	RNA	DNP	GG	AA	AA			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr14:106829984_106829985GG>AA	uc010tyt.1	-	323		c.12520_12521CC>TT			uc001ysx.1_Intron					Parts of antibodies, mostly variable regions.												0						CTCACATCTGGGAGCTGCCACC	0.535000													10	40					0	0	0.004672	0	0
C15orf2	23742	broad.mit.edu	37	15	24924253	24924253	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr15:24924253G>A	uc001ywo.2	+	1	3713	c.3239G>A	c.(3238-3240)GGA>GAA	p.G1080E		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	1080					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CCTGTATTTGGATATACTTCT	0.537000													17	79					0	0	0.008871	0	0
TAOK2	9344	broad.mit.edu	37	16	29998819	29998819	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr16:29998819C>T	uc002dva.1	+	16	4009	c.3226C>T	c.(3226-3228)CGG>TGG	p.R1076W	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Intron|TAOK2_uc002dvc.1_Intron|TAOK2_uc010bzm.1_Missense_Mutation_p.R1083W|TAOK2_uc002dvd.1_Missense_Mutation_p.R903W	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	1076					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						GCAGGGCCCCCGGGTGCGCCG	0.701000													10	54					0	0	0.001368	0	0
CASKIN2	57513	broad.mit.edu	37	17	73497865	73497865	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr17:73497865C>T	uc002joc.2	-	18	3840	c.3290G>A	c.(3289-3291)GGA>GAA	p.G1097E	CASKIN2_uc010wsc.1_Missense_Mutation_p.G1015E	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	1097	Pro-rich.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CTTACCTGCTCCGGGCACCTT	0.642000													40	94					0	0	0.002222	0	0
MC5R	4161	broad.mit.edu	37	18	13826737	13826737	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr18:13826737G>A	uc010xaf.1	+	1	973	c.973G>A	c.(973-975)GAT>AAT	p.D325N		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	325	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						TCCCAGAAGGGATTAAGCACA	0.522000													26	65					0	0	0.004656	0	0
VAV1	7409	broad.mit.edu	37	19	6821684	6821684	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr19:6821684G>A	uc002mfu.1	+	3	470	c.373G>A	c.(373-375)GGG>AGG	p.G125R	VAV1_uc010xjh.1_Missense_Mutation_p.G125R|VAV1_uc010dva.1_Missense_Mutation_p.G125R|VAV1_uc002mfv.1_Missense_Mutation_p.G70R	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	125					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						CCAGAACAGGGGGATCATGTG	0.642000													9	50					0	0	0.000978	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15582857	15582857	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr19:15582857C>T	uc002nbf.3	-	3	1320	c.1187G>A	c.(1186-1188)CGC>CAC	p.R396H	PGLYRP2_uc002nbg.3_Missense_Mutation_p.R396H	NM_052890	NP_443122	Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2 precursor	396					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)	3						CAGCTTCGGGCGGCCCCGATA	0.657000													6	34					0	0	0.003080	0	0
AP1M1	8907	broad.mit.edu	37	19	16345234	16345235	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr19:16345234_16345235CC>TT	uc002ndu.2	+	12	1433_1434	c.1260_1261CC>TT	c.(1258-1263)CTCCGG>CTTTGG	p.R421W	AP1M1_uc002ndv.2_Missense_Mutation_p.R433W|AP1M1_uc010xpd.1_Missense_Mutation_p.R368W	NM_032493	NP_115882	Q9BXS5	AP1M1_HUMAN	adaptor-related protein complex 1, mu 1 subunit	421	MHD.				cellular membrane organization|endosome to melanosome transport|interspecies interaction between organisms|intracellular protein transport|melanosome organization|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			ovary(3)|breast(1)	4						ATTACCAGCTCCGGACCCAGTG	0.688000													12	38					0	0	0.004672	0	0
ZNF780B	163131	broad.mit.edu	37	19	40540452	40540452	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr19:40540452G>A	uc002omu.2	-	5	2379	c.2314C>T	c.(2314-2316)CAG>TAG	p.Q772*	ZNF780B_uc002omv.2_Nonsense_Mutation_p.Q624*	NM_001005851	NP_001005851	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	772	C2H2-type 22; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TGAATACTCTGAGGTTGAACA	0.418000													21	40					0	0	0.001882	0	0
CYP2B7P1	1556	broad.mit.edu	37	19	41430339	41430339	+	Silent	SNP	C	T	T			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr19:41430339C>T	uc010ehg.1	+	1	170	c.162C>T	c.(160-162)TCC>TCT	p.S54S	CYP2A7_uc002opo.2_Intron|CYP2B7P1_uc010ehh.1_Silent_p.S54S|CYP2B7P1_uc002opq.2_RNA					SubName: Full=Cytochrome P450 2B7 short isoform; SubName: Full=CYP2B protein;											ovary(1)|skin(1)	2						TACTCAAATCCTTTCTGAGGG	0.562000													24	53					0	0	0.005443	0	0
TEX101	83639	broad.mit.edu	37	19	43922418	43922418	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr19:43922418G>A	uc010xwo.1	+	6	814	c.619G>A	c.(619-621)GAA>AAA	p.E207K	TEX101_uc002owk.2_Missense_Mutation_p.E225K	NM_001130011	NP_001123483	Q9BY14	TX101_HUMAN	testis expressed 101 isoform 2	207						anchored to membrane|plasma membrane				ovary(1)	1		Prostate(69;0.0199)				GTTTGTGAGGGAAGCGTGCCC	0.527000													30	68					0	0	0.007291	0	0
FOSB	2354	broad.mit.edu	37	19	45974075	45974075	+	Silent	SNP	C	T	T			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr19:45974075C>T	uc002pbx.3	+	2	907	c.315C>T	c.(313-315)TCC>TCT	p.S105S	ERCC1_uc002pbu.1_Intron|FOSB_uc002pbw.2_Silent_p.S105S|FOSB_uc010eke.2_Silent_p.S66S|FOSB_uc002pby.3_Silent_p.S105S|FOSB_uc010eka.1_Silent_p.S66S|FOSB_uc010ekb.1_Silent_p.S105S|FOSB_uc010ekc.1_Intron|FOSB_uc010ekf.2_Silent_p.S66S|FOSB_uc010ekd.1_Silent_p.S105S|FOSB_uc010ekg.2_Intron|FOSB_uc002pca.3_Silent_p.S56S	NM_006732	NP_006723	P53539	FOSB_HUMAN	FBJ murine osteosarcoma viral oncogene homolog B	105					behavior|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|lung(1)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00814)|Epithelial(262;0.18)|GBM - Glioblastoma multiforme(486;0.242)		CCAGCTACTCCACACCAGGCA	0.682000													50	134					0	0	0.003610	0	0
TRMT61B	55006	broad.mit.edu	37	2	29092917	29092917	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr2:29092917T>G	uc002rmm.2	-	1	259	c.227A>C	c.(226-228)GAC>GCC	p.D76A	TRMT61B_uc002rmn.2_Missense_Mutation_p.D76A|TRMT61B_uc010ezk.2_RNA	NM_017910	NP_060380	Q9BVS5	TR61B_HUMAN	tRNA methyltransferase 61 homolog B	76							tRNA (adenine-N1-)-methyltransferase activity				0						AGTCCCAATGTCCGAGATGCT	0.587000													9	82					0	0	0.006214	0	0
LRP1B	53353	broad.mit.edu	37	2	141201982	141201982	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr2:141201982G>A	uc002tvj.1	-	65	11183	c.10211C>T	c.(10210-10212)ACC>ATC	p.T3404I		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3404	Extracellular (Potential).|LDL-receptor class A 23.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTGGTTCTTGGTACATTTGAA	0.383000										TSP Lung(27;0.18)			4	11					0	0	0.000248	0	0
GRB14	2888	broad.mit.edu	37	2	165383625	165383625	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr2:165383625C>T	uc002ucl.2	-	4	1043	c.502G>A	c.(502-504)GAA>AAA	p.E168K	GRB14_uc010zcv.1_Missense_Mutation_p.E81K|GRB14_uc002ucm.2_RNA	NM_004490	NP_004481	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	168	Ras-associating.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			ovary(5)|upper_aerodigestive_tract(1)|lung(1)	7						ATCACCAGTTCGTGGTCTTCT	0.264000													8	20					0	0	0.006214	0	0
SF3B1	23451	broad.mit.edu	37	2	198267483	198267483	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr2:198267483C>T	uc002uue.2	-	14	1922	c.1874G>A	c.(1873-1875)CGT>CAT	p.R625H		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	625	HEAT 3.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TGTTGTGTTACGGACATACTC	0.438000													9	26					0	0	0.004482	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209191128	209191128	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr2:209191128T>G	uc002vcz.2	+	20	3751	c.3593T>G	c.(3592-3594)CTG>CGG	p.L1198R	PIKFYVE_uc010fun.1_Missense_Mutation_p.L879R|PIKFYVE_uc002vcy.1_Missense_Mutation_p.L1142R	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	1198					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						GGGCTTATTCTGAGTGATGCT	0.433000													4	13					0	0	0.000602	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3674962	3674962	+	Silent	SNP	G	A	A			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr20:3674962G>A	uc002wja.2	-	12	3162	c.3162C>T	c.(3160-3162)ATC>ATT	p.I1054I	SIGLEC1_uc002wjb.1_5'Flank|SIGLEC1_uc002wiz.3_Silent_p.I1054I	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	1054	Ig-like C2-type 10.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						TAGCCCCGTGGATCTCCAGAC	0.622000													40	119					0	0	0.002522	0	0
FRG1B	284802	broad.mit.edu	37	20	29628300	29628300	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr20:29628300G>A	uc010ztl.1	+	3	244	c.212G>A	c.(211-213)AGT>AAT	p.S71N	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Missense_Mutation_p.S23N					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						GAAGCAAAAAGTAAAACAGCA	0.358000													5	29					0	0	0.001168	0	0
PPIL2	23759	broad.mit.edu	37	22	22049076	22049076	+	Silent	SNP	C	T	T	rs148599036		TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr22:22049076C>T	uc010gtj.1	+	18	1418	c.1302C>T	c.(1300-1302)TTC>TTT	p.F434F	PPIL2_uc002zvh.3_Silent_p.F434F|PPIL2_uc002zvi.3_Silent_p.F434F|PPIL2_uc002zvg.3_Silent_p.F434F|PPIL2_uc011aij.1_Silent_p.F413F|PPIL2_uc002zvk.3_Silent_p.F180F	NM_148175	NP_680480	Q13356	PPIL2_HUMAN	peptidylprolyl isomerase-like 2 isoform a	434					blood coagulation|leukocyte migration|protein folding|protein polyubiquitination	Golgi lumen|nucleus|ubiquitin ligase complex	peptidyl-prolyl cis-trans isomerase activity|ubiquitin-ubiquitin ligase activity			ovary(2)	2	Colorectal(54;0.105)					CTACAGTGTTCGTGGACCCCT	0.647000													14	54					0	0	0.003163	0	0
CNTN6	27255	broad.mit.edu	37	3	1414548	1414548	+	Silent	SNP	G	A	A			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr3:1414548G>A	uc003boz.2	+	14	1962	c.1695G>A	c.(1693-1695)AGG>AGA	p.R565R	CNTN6_uc011asj.1_Silent_p.R493R|CNTN6_uc003bpa.2_Silent_p.R565R	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	565	Ig-like C2-type 6.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		TGATGATAAGGAATATTCAGT	0.373000													8	36					0	0	0.008291	0	0
SEMA5B	54437	broad.mit.edu	37	3	122629053	122629053	+	Silent	SNP	G	A	A			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr3:122629053G>A	uc003efz.1	-	23	3697	c.3393C>T	c.(3391-3393)CCC>CCT	p.P1131P	SEMA5B_uc011bju.1_Silent_p.P1037P|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003efy.1_Silent_p.P109P	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	1131	Cytoplasmic (Potential).				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		GTTTGTTCAGGGGGCTTGGGT	0.542000													21	49					0	0	0.002299	0	0
DGKG	1608	broad.mit.edu	37	3	185970917	185970917	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr3:185970917C>T	uc003fqa.2	-	18	2102	c.1565G>A	c.(1564-1566)GGA>GAA	p.G522E	DGKG_uc003fqb.2_Missense_Mutation_p.G483E|DGKG_uc003fqc.2_Missense_Mutation_p.G497E|DGKG_uc011brx.1_Missense_Mutation_p.G463E	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	522	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	AAGGTCATTTCCTGTTCCAAG	0.517000													17	58					0	0	0.001882	0	0
HNRNPD	3184	broad.mit.edu	37	4	83277705	83277705	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr4:83277705A>G	uc003hmm.1	-	7	1303	c.985T>C	c.(985-987)TAT>CAT	p.Y329H	HNRNPD_uc003hml.1_Intron|HNRNPD_uc003hmn.1_Missense_Mutation_p.Y310H|HNRNPD_uc003hmo.1_Intron|HNRNPD_uc003hmp.1_Intron|HNRNPD_uc010ijr.1_Missense_Mutation_p.Y310H|HNRNPD_uc011cci.1_Missense_Mutation_p.Y175H	NM_031370	NP_112738	Q14103	HNRPD_HUMAN	heterogeneous nuclear ribonucleoprotein D	329	Gly-rich.|Tyr-rich.				nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|RNA catabolic process|transcription, DNA-dependent	cytosol|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|telomeric DNA binding				0						TAATCACCATATCCATAGTAG	0.348000													13	33					0	0	0.003163	0	0
HHIP	64399	broad.mit.edu	37	4	145567871	145567871	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr4:145567871C>T	uc003ijs.1	+	1	699	c.44C>T	c.(43-45)GCT>GTT	p.A15V	uc003ijq.1_5'Flank|HHIP_uc003ijr.1_Missense_Mutation_p.A15V	NM_022475	NP_071920	Q96QV1	HHIP_HUMAN	hedgehog-interacting protein precursor	15						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		CTGGCCGTGGCTCTGGGCTTC	0.617000											OREG0016346	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	35	84					0	0	0.004289	0	0
RARS	5917	broad.mit.edu	37	5	167943886	167943887	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr5:167943886_167943887CC>TT	uc003lzx.2	+	13	1597_1598	c.1556_1557CC>TT	c.(1555-1557)TCC>TTT	p.S519F	RARS_uc011deo.1_Missense_Mutation_p.S313F	NM_002887	NP_002878	P54136	SYRC_HUMAN	arginyl-tRNA synthetase	519					arginyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|skin(1)	3	Renal(175;0.000159)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0208)|all_neural(177;0.0227)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0693)|Epithelial(171;0.131)|OV - Ovarian serous cystadenocarcinoma(192;0.156)		TACATCTTCTCCTTTGACAAAA	0.411000													31	76					0	0	0.004672	0	0
COL23A1	91522	broad.mit.edu	37	5	177683870	177683870	+	Silent	SNP	C	T	T			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr5:177683870C>T	uc003mje.2	-	14	1192	c.834G>A	c.(832-834)CCG>CCA	p.P278P	COL23A1_uc010jkt.2_Missense_Mutation_p.R126Q	NM_173465	NP_775736	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1	278	Extracellular (Potential).|Collagen-like 2.|Gly-rich.					collagen|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)|skin(1)	2	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		ATGTCACCTTCGGTCCTGGGG	0.632000													10	15					0	0	0.008291	0	0
MDH2	4191	broad.mit.edu	37	7	75694157	75694157	+	Silent	SNP	C	T	T			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr7:75694157C>T	uc003ueo.2	+	8	857	c.771C>T	c.(769-771)CGC>CGT	p.R257R	MDH2_uc003uep.2_Silent_p.R150R|MDH2_uc011kgh.1_Silent_p.R215R	NM_005918	NP_005909	P40926	MDHM_HUMAN	mitochondrial malate dehydrogenase precursor	257					gluconeogenesis|malate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus|plasma membrane	binding|L-malate dehydrogenase activity			ovary(1)|central_nervous_system(1)|skin(1)	3					NADH(DB00157)	CCGGCGCCCGCTTTGTCTTCT	0.572000													13	31					0	0	0.001855	0	0
MYOM2	9172	broad.mit.edu	37	8	2021526	2021526	+	Missense_Mutation	SNP	C	A	A			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr8:2021526C>A	uc003wpx.3	+	10	1204	c.1066C>A	c.(1066-1068)CGC>AGC	p.R356S	MYOM2_uc011kwi.1_Intron	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	356	Ig-like C2-type 2.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		GTACACCCTGCGCATCGTGTC	0.617000													10	26					4.68919e-08	7.88636e-08	0.008291	1	0
GNAQ	2776	broad.mit.edu	37	9	80409488	80409488	+	Missense_Mutation	SNP	T	G	G	rs121913492		TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr9:80409488T>G	uc004akw.2	-	5	667	c.626A>C	c.(625-627)CAA>CCA	p.Q209P	GNAQ_uc011lso.1_Missense_Mutation_p.Q7P	NM_002072	NP_002063	P50148	GNAQ_HUMAN	guanine nucleotide binding protein (G protein),	209	GTP (By similarity).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|glutamate signaling pathway|negative regulation of protein kinase activity|platelet activation|protein ADP-ribosylation|protein stabilization|regulation of action potential|regulation of catenin import into nucleus	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activator activity|GTPase activity|signal transducer activity	p.Q209L(89)|p.Q209P(88)|p.Q209R(2)|p.Q209Y(1)|p.Q209H(1)		eye(136)|skin(44)|meninges(11)|ovary(1)|kidney(1)	193						CTCTGACCTTTGGCCCCCTAC	0.348000			Mis		uveal melanoma								18	22					0	0	0.003330	0	0
GJD4	219770	broad.mit.edu	37	10	35897462	35897462	+	Frame_Shift_Del	DEL	C	-	-			TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr10:35897462delC	uc001iyy.1	+	2	1179	c.1021delC	c.(1021-1023)CCCfs	p.P341fs		NM_153368	NP_699199	Q96KN9	CXD4_HUMAN	connexin40.1	341	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane				large_intestine(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						CCTGGCCGCGCCCCCTTCCTG	0.706													2	4	---	---	---	---					
GLYAT	10249	broad.mit.edu	37	11	58480294	58480295	+	Frame_Shift_Ins	INS	-	T	T	rs137908036	byFrequency	TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr11:58480294_58480295insT	uc001nnb.2	-	4	409_410	c.254_255insA	c.(253-255)AACfs	p.N85fs	GLYAT_uc001nnc.2_Frame_Shift_Ins_p.N85fs	NM_201648	NP_964011	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase isoform a	85					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	ATTCCTGACAGTTTTGGGGATC	0.381													2	4	---	---	---	---					
SYN2	6854	broad.mit.edu	37	3	12046124	12046126	+	In_Frame_Del	DEL	AGC	-	-	rs76272937		TCGA-ER-A2NF-01A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	0884fdf3-7a20-43bc-bf57-e71f36e11ab9	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr3:12046124_12046126delAGC	uc003bwm.2	+	1	263_265	c.99_101delAGC	c.(97-102)CAACCG>CAG	p.P40del	SYN2_uc003bwl.1_In_Frame_Del_p.P40del	NM_133625	NP_598328	Q92777	SYN2_HUMAN	synapsin II isoform IIa	40					neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			ovary(1)|central_nervous_system(1)	2						AGCCCCAGCAAGCGCCGAcgccg	0.345													2	4	---	---	---	---					
