Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NBL1	4681	broad.mit.edu	37	1	19981874	19981874	+	Silent	SNP	A	C	C			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr1:19981874A>C	uc001bck.1	+	3	380	c.225A>C	c.(223-225)ACA>ACC	p.T75T	NBL1_uc009vpl.1_Silent_p.T76T|NBL1_uc001bcj.1_Silent_p.T111T|NBL1_uc009vpm.1_Silent_p.T76T	NM_005380	NP_005371	P41271	NBL1_HUMAN	neuroblastoma, suppression of tumorigenicity 1 2	75	CTCK.					extracellular region				ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00043)|Ovarian(437;0.00373)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.9e-05)|Kidney(64;0.000173)|GBM - Glioblastoma multiforme(114;0.0012)|KIRC - Kidney renal clear cell carcinoma(64;0.0026)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CACAGTCCACAGAGTCCCTGG	0.622000													28	64					0	0	0.069456	0	0
ERI3	79033	broad.mit.edu	37	1	44804751	44804751	+	Missense_Mutation	SNP	T	G	G			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr1:44804751T>G	uc001clt.2	-	3	696	c.455A>C	c.(454-456)GAG>GCG	p.E152A	ERI3_uc010okv.1_Intron|ERI3_uc009vxg.2_Missense_Mutation_p.E152A|ERI3_uc010okw.1_Missense_Mutation_p.E74A|ERI3_uc001clu.2_Missense_Mutation_p.E74A	NM_024066	NP_076971	O43414	ERI3_HUMAN	prion protein interacting protein	152	Exonuclease.	Magnesium 1 (By similarity).|Proton acceptor (Potential).|AMP (By similarity).				intracellular	exonuclease activity|metal ion binding|nucleic acid binding			ovary(2)|large_intestine(1)	3						GCACGTGGCCTCAAAGTCCAG	0.547000													145	229					0	0	0.048971	0	0
ANKRD34A	284615	broad.mit.edu	37	1	145473827	145473827	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr1:145473827G>A	uc001enq.1	+	4	1792	c.499G>A	c.(499-501)GGG>AGG	p.G167R	NBPF10_uc001emp.3_Intron	NM_001039888	NP_001034977	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34	167											0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ACCATCCCCAGGGGTGGAGGA	0.617000													23	94					0	0	0.083992	0	0
FLG	2312	broad.mit.edu	37	1	152275719	152275719	+	Silent	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr1:152275719C>T	uc001ezu.1	-	3	11679	c.11643G>A	c.(11641-11643)GAG>GAA	p.E3881E		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3881	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGAAGCAGACTCAGATCGCC	0.567000									Ichthyosis				43	158					0	0	0.098360	0	0
CRNN	49860	broad.mit.edu	37	1	152383181	152383181	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr1:152383181G>A	uc001ezx.2	-	3	451	c.377C>T	c.(376-378)GCG>GTG	p.A126V		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	126					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCTTTCCCCGCCCTTCCCAC	0.637000													13	448					0	0	0.020292	0	0
PEAR1	375033	broad.mit.edu	37	1	156883725	156883725	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr1:156883725C>T	uc001fqj.1	+	22	2911	c.2795C>T	c.(2794-2796)CCC>CTC	p.P932L	PEAR1_uc001fqk.1_Missense_Mutation_p.P557L	NM_001080471	NP_001073940	Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	932	Pro-rich.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CGGGACCTGCCCAGCTTGCCA	0.617000													33	40					0	0	0.050027	0	0
PAPPA2	60676	broad.mit.edu	37	1	176525627	176525627	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr1:176525627C>T	uc001gkz.2	+	2	1333	c.169C>T	c.(169-171)CGA>TGA	p.R57*	PAPPA2_uc001gky.1_Nonsense_Mutation_p.R57*|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	57					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GGCCAAGGTTCGAAGACCCAG	0.567000													113	132					0	0	0.048971	0	0
RGS21	431704	broad.mit.edu	37	1	192321182	192321182	+	Missense_Mutation	SNP	C	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr1:192321182C>A	uc001gsh.2	+	4	268	c.94C>A	c.(94-96)CTA>ATA	p.L32I		NM_001039152	NP_001034241	Q2M5E4	RGS21_HUMAN	regulator of G-protein signaling 21	32	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|skin(1)	2						TATAGCTGGTCTAGATGCTTT	0.303000													19	41					1.56452e-12	1.74739e-12	0.043863	1	0
IKBKE	9641	broad.mit.edu	37	1	206647731	206647731	+	Missense_Mutation	SNP	C	T	T	rs143140330		TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr1:206647731C>T	uc001hdz.1	+	4	513	c.145C>T	c.(145-147)CGC>TGC	p.R49C	IKBKE_uc009xbu.1_Missense_Mutation_p.R49C|IKBKE_uc009xbv.1_Missense_Mutation_p.R49C|IKBKE_uc001hea.1_5'UTR	NM_014002	NP_054721	Q14164	IKKE_HUMAN	IKK-related kinase epsilon	49	Protein kinase.				DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			ovary(3)|lung(3)|central_nervous_system(1)|skin(1)	8	Breast(84;0.137)					CCTGCGGCCCCGCGAGGTGCA	0.582000													23	31					0	0	0.034045	0	0
CCKBR	887	broad.mit.edu	37	11	6292257	6292257	+	Silent	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr11:6292257C>T	uc001mcp.2	+	5	1021	c.828C>T	c.(826-828)AAC>AAT	p.N276N	CCKBR_uc001mcq.2_Silent_p.N204N|CCKBR_uc001mcr.2_Silent_p.N276N|CCKBR_uc001mcs.2_Silent_p.N345N|CCKBR_uc001mct.1_RNA	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	276	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	TTCACCAGAACGGGCGTTGCC	0.662000													4	104					0	0	0.021553	0	0
DNHD1	144132	broad.mit.edu	37	11	6588129	6588129	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr11:6588129G>A	uc001mdw.3	+	36	11954	c.11390G>A	c.(11389-11391)CGG>CAG	p.R3797Q	DNHD1_uc001mea.3_Missense_Mutation_p.R66Q|DNHD1_uc001meb.2_Missense_Mutation_p.R65Q|DNHD1_uc001mec.2_Missense_Mutation_p.R65Q|DNHD1_uc010rao.1_Intron|DNHD1_uc009yfg.2_5'Flank	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	3797					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		ATGCAGGAGCGGCTGCTGACG	0.542000													7	6					0	0	0.047766	0	0
DNHD1	144132	broad.mit.edu	37	11	6588423	6588423	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr11:6588423G>A	uc001mdw.3	+	36	12248	c.11684G>A	c.(11683-11685)CGT>CAT	p.R3895H	DNHD1_uc001mea.3_Missense_Mutation_p.R164H|DNHD1_uc001meb.2_Missense_Mutation_p.R163H|DNHD1_uc001mec.2_Missense_Mutation_p.R163H|DNHD1_uc010rao.1_Missense_Mutation_p.R153H|DNHD1_uc009yfg.2_5'Flank	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	3895					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		ATGAAGCCACGTGAGATTAAT	0.577000													46	116					0	0	0.048971	0	0
OR10A5	144124	broad.mit.edu	37	11	6867517	6867517	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr11:6867517G>A	uc001met.1	+	1	604	c.604G>A	c.(604-606)GTC>ATC	p.V202I		NM_178168	NP_835462	Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A,	202	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CTACGCCATCGTCGGAACCAT	0.512000													53	135					0	0	0.048971	0	0
CD82	3732	broad.mit.edu	37	11	44640201	44640201	+	Silent	SNP	G	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr11:44640201G>A	uc001myc.2	+	9	902	c.654G>A	c.(652-654)GAG>GAA	p.E218E	CD82_uc001myd.2_Silent_p.E193E	NM_002231	NP_002222	P27701	CD82_HUMAN	CD82 antigen isoform 1	218	Extracellular (Potential).					integral to plasma membrane	protein binding			ovary(1)	1						GCTGCATGGAGAAGGTGCAGG	0.667000													20	70					0	0	0.091800	0	0
EFEMP2	30008	broad.mit.edu	37	11	65638766	65638766	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr11:65638766C>T	uc001ofy.3	-	4	423	c.229G>A	c.(229-231)GGC>AGC	p.G77S	EFEMP2_uc001ofz.2_RNA|EFEMP2_uc001oga.2_Missense_Mutation_p.G77S	NM_016938	NP_058634	O95967	FBLN4_HUMAN	EGF-containing fibulin-like extracellular matrix	77	EGF-like 1; atypical.				blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.169)		CACAAGTAGCCCCCGTAGTGG	0.647000													36	138					0	0	0.111260	0	0
CCDC84	338657	broad.mit.edu	37	11	118885707	118885707	+	Missense_Mutation	SNP	C	G	G			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr11:118885707C>G	uc001pul.2	+	9	775	c.719C>G	c.(718-720)GCC>GGC	p.A240G	CCDC84_uc010ryk.1_RNA|CCDC84_uc010ryl.1_RNA|CCDC84_uc010rym.1_RNA	NM_198489	NP_940891	Q86UT8	CCD84_HUMAN	coiled-coil domain containing 84	240										ovary(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_neural(223;0.224)|all_hematologic(192;0.243)		BRCA - Breast invasive adenocarcinoma(274;7.72e-05)		TTTTCAGGTGCCACACCTCCC	0.353000													31	71					0	0	0.037714	0	0
ACAD8	27034	broad.mit.edu	37	11	134130962	134130962	+	Missense_Mutation	SNP	C	G	G			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr11:134130962C>G	uc001qhk.2	+	7	791	c.730C>G	c.(730-732)CGA>GGA	p.R244G	ACAD8_uc010sco.1_3'UTR|ACAD8_uc010scp.1_RNA|ACAD8_uc010scq.1_Missense_Mutation_p.R167G|ACAD8_uc001qhl.2_Missense_Mutation_p.R117G|ACAD8_uc010scr.1_3'UTR|ACAD8_uc009zde.1_3'UTR	NM_014384	NP_055199	Q9UKU7	ACAD8_HUMAN	acyl-Coenzyme A dehydrogenase family, member 8	244					branched chain family amino acid catabolic process|lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding				0	all_hematologic(175;0.127)	all_cancers(12;8e-23)|all_epithelial(12;2.59e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|all_neural(223;0.0189)|Medulloblastoma(222;0.0245)|Esophageal squamous(93;0.0559)		Epithelial(10;1.92e-10)|all cancers(11;2.26e-09)|BRCA - Breast invasive adenocarcinoma(10;8.73e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00154)|Lung(977;0.21)		CCAGCCAACACGAGCTGTGAT	0.612000													3	23					0	0	0.009096	0	0
TPP2	7174	broad.mit.edu	37	13	103299660	103299660	+	Missense_Mutation	SNP	G	C	C	rs142623109		TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr13:103299660G>C	uc001vpi.3	+	21	2697	c.2594G>C	c.(2593-2595)AGA>ACA	p.R865T		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	865					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CAGAACAAAAGACAGATGGGT	0.388000													23	43					0	0	0.062417	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42434838	42434838	+	Silent	SNP	G	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr15:42434838G>A	uc001zoz.2	-	19	2280	c.2217C>T	c.(2215-2217)GAC>GAT	p.D739D	PLA2G4F_uc010bcq.2_Silent_p.D36D|PLA2G4F_uc001zoy.2_Silent_p.D371D|PLA2G4F_uc010bcr.2_Silent_p.D490D|PLA2G4F_uc001zpa.2_Silent_p.D490D|PLA2G4F_uc010bcs.2_Silent_p.D526D	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	739	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		CCTCCTCCATGTCCTCAGGGC	0.592000													26	69					0	0	0.034045	0	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr15:102515299G>A	uc002cdi.2	+	9	1943	c.523G>A	c.(523-525)GGC>AGC	p.G175S	WASH3P_uc002cdl.2_Missense_Mutation_p.G175S|WASH3P_uc002cdk.2_RNA|WASH3P_uc002cdp.2_Missense_Mutation_p.G175S|WASH3P_uc010bpo.2_RNA|WASH3P_uc002cdq.2_RNA|WASH3P_uc002cdr.2_RNA	NR_003659				RecName: Full=WAS protein family homolog 2; AltName: Full=Protein FAM39B; AltName: Full=CXYorf1-like protein on chromosome 2;												0						TGGGGGCATCGGCAAGGCCAA	0.652000													6	4					0	0	0.029380	0	0
PKD1	5310	broad.mit.edu	37	16	2164291	2164291	+	Silent	SNP	C	A	A	rs4018173		TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr16:2164291C>A	uc002cos.1	-	11	2942	c.2733G>T	c.(2731-2733)GTG>GTT	p.V911V	PKD1_uc002cot.1_Silent_p.V911V	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	911	Extracellular (Potential).|PKD 3.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						TTTCCACCACCACGTCCACCA	0.697000													4	36					0.00198382	0.00218729	0.029380	1	0
RPGRIP1L	23322	broad.mit.edu	37	16	53679916	53679916	+	Splice_Site	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr16:53679916C>T	uc002ehp.2	-	17	2369	c.2305_splice	c.e17-1	p.L769_splice	RPGRIP1L_uc002eho.3_Splice_Site_p.L769_splice|RPGRIP1L_uc010vgy.1_Splice_Site_p.L769_splice|RPGRIP1L_uc010cbx.2_Splice_Site_p.L769_splice|RPGRIP1L_uc010vgz.1_Splice_Site_p.L769_splice	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a						negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				GCTGACTTAACTGGAAAAACA	0.358000													21	47					0	0	0.055883	0	0
POLR2A	5430	broad.mit.edu	37	17	7414879	7414879	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr17:7414879C>T	uc002ghf.3	+	24	4307	c.4073C>T	c.(4072-4074)ACG>ATG	p.T1358M		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	1358					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				GTACGCACCACGTCCAATGAC	0.597000													8	29					0	0	0.058154	0	0
KRT222	125113	broad.mit.edu	37	17	38812821	38812821	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr17:38812821G>A	uc002hvc.2	-	6	786	c.721C>T	c.(721-723)CGA>TGA	p.R241*	KRT222_uc010wfk.1_RNA|KRT222_uc002hvb.2_Nonsense_Mutation_p.R201*	NM_152349	NP_689562	Q8N1A0	KT222_HUMAN	truncated type I keratin KA21	241						intermediate filament	structural molecule activity			central_nervous_system(1)|skin(1)	2						TTCCTCAATCGAGGGTTATCT	0.338000													34	85					0	0	0.059317	0	0
SERPINB7	8710	broad.mit.edu	37	18	61449736	61449736	+	Missense_Mutation	SNP	T	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr18:61449736T>A	uc002ljl.2	+	2	226	c.130T>A	c.(130-132)TTG>ATG	p.L44M	SERPINB7_uc002ljm.2_Missense_Mutation_p.L44M|SERPINB7_uc010xet.1_Missense_Mutation_p.L44M|SERPINB7_uc010dqg.2_Missense_Mutation_p.L44M	NM_001040147	NP_001035237	O75635	SPB7_HUMAN	serine (or cysteine) proteinase inhibitor, clade	44					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			lung(2)|central_nervous_system(1)	3		Esophageal squamous(42;0.129)				CCTGGTCCGCTTGGGCGCTCA	0.473000													38	94					0	0	0.104719	0	0
DENND1C	79958	broad.mit.edu	37	19	6468913	6468913	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr19:6468913G>A	uc002mfe.2	-	20	1551	c.1459C>T	c.(1459-1461)CCC>TCC	p.P487S	DENND1C_uc002mfb.2_Missense_Mutation_p.P37S|DENND1C_uc002mfc.2_Missense_Mutation_p.P37S|DENND1C_uc002mfd.2_Missense_Mutation_p.P37S|DENND1C_uc010xje.1_Missense_Mutation_p.P443S	NM_024898	NP_079174	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	487						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1						GAGCGGCTGGGGAGGGCTGGG	0.617000													12	17					0	0	0.105934	0	0
ZNF675	171392	broad.mit.edu	37	19	23836144	23836144	+	Missense_Mutation	SNP	T	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr19:23836144T>A	uc002nri.2	-	4	1773	c.1591A>T	c.(1591-1593)ACT>TCT	p.T531S		NM_138330	NP_612203	Q8TD23	ZN675_HUMAN	zinc finger protein 675	531					bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|kidney(1)	2		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TTCTCTCCAGTATGAATTATC	0.343000													21	71					0	0	0.062417	0	0
ZNF536	9745	broad.mit.edu	37	19	31038959	31038959	+	Silent	SNP	G	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr19:31038959G>A	uc002nsu.1	+	4	2571	c.2433G>A	c.(2431-2433)CCG>CCA	p.P811P	ZNF536_uc010edd.1_Silent_p.P811P	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	811					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GGGCTGGGCCGCTGTCTGGGC	0.567000													32	90					0	0	0.080422	0	0
KIAA0355	9710	broad.mit.edu	37	19	34832986	34832986	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr19:34832986G>A	uc002nvd.3	+	10	3006	c.2147G>A	c.(2146-2148)GGA>GAA	p.G716E		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	716										ovary(1)	1	Esophageal squamous(110;0.162)					CCCCAGCCGGGACTGGCACCT	0.647000													54	142					0	0	0.048971	0	0
TNNT1	7138	broad.mit.edu	37	19	55649402	55649402	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr19:55649402C>T	uc002qjb.3	-	10	517	c.428G>A	c.(427-429)CGG>CAG	p.R143Q	TNNT1_uc002qiz.3_Missense_Mutation_p.R73Q|TNNT1_uc002qja.3_Missense_Mutation_p.R73Q|TNNT1_uc002qjc.3_Missense_Mutation_p.R143Q|TNNT1_uc002qje.3_Missense_Mutation_p.R132Q|TNNT1_uc002qjd.3_Missense_Mutation_p.R132Q|TNNT1_uc002qjf.2_Missense_Mutation_p.R139Q	NM_003283	NP_003274	P13805	TNNT1_HUMAN	troponin T1, skeletal, slow isoform a	143					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		ATCCTCTGCCCGCTTCTTGGC	0.532000													32	97					0	0	0.074837	0	0
CLASP1	23332	broad.mit.edu	37	2	122139824	122139824	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr2:122139824C>T	uc002tnc.2	-	32	3841	c.3451G>A	c.(3451-3453)GCT>ACT	p.A1151T	CLASP1_uc010yyv.1_Intron|CLASP1_uc002tmz.2_Missense_Mutation_p.A236T|CLASP1_uc002tna.2_Intron|CLASP1_uc010yyw.1_Intron|CLASP1_uc002tnb.2_Intron|CLASP1_uc010yyx.1_Intron|CLASP1_uc010yyy.1_Intron|CLASP1_uc010yyz.1_Intron|CLASP1_uc010yza.1_Intron|CLASP1_uc010yzb.1_Intron|CLASP1_uc010yzc.1_Intron|CLASP1_uc002tnf.2_Intron	NM_015282	NP_056097	Q7Z460	CLAP1_HUMAN	CLIP-associating protein 1 isoform 1	1151					axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			ovary(1)|central_nervous_system(1)	2	Renal(3;0.0496)					TGGGAGGGAGCGGTGGGGATG	0.522000													10	11					0	0	0.093190	0	0
BIN1	274	broad.mit.edu	37	2	127828379	127828379	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr2:127828379C>T	uc002tns.1	-	3	524	c.179G>A	c.(178-180)CGG>CAG	p.R60Q	BIN1_uc010yzf.1_Missense_Mutation_p.R36Q|BIN1_uc010yzg.1_Missense_Mutation_p.R60Q|BIN1_uc002tnu.1_Missense_Mutation_p.R60Q|BIN1_uc002toa.1_Missense_Mutation_p.R60Q|BIN1_uc002tnt.1_Missense_Mutation_p.R60Q|BIN1_uc002tnv.1_Missense_Mutation_p.R60Q|BIN1_uc002tnw.1_Missense_Mutation_p.R60Q|BIN1_uc002tnx.1_Missense_Mutation_p.R60Q|BIN1_uc002tny.1_Missense_Mutation_p.R60Q|BIN1_uc002tnz.1_Missense_Mutation_p.R60Q|BIN1_uc002tob.1_Missense_Mutation_p.R60Q|BIN1_uc002toc.1_Missense_Mutation_p.R60Q	NM_139343	NP_647593	O00499	BIN1_HUMAN	bridging integrator 1 isoform 1	60	BAR.|Interaction with BIN2.				cell proliferation|endocytosis|interspecies interaction between organisms|multicellular organismal development	actin cytoskeleton|nucleus				ovary(2)|central_nervous_system(2)|skin(2)|lung(1)	7	Colorectal(110;0.0831)			BRCA - Breast invasive adenocarcinoma(221;0.073)		CTTCTGCAGCCGGGTGCCCTC	0.637000													12	41					0	0	0.093190	0	0
LCT	3938	broad.mit.edu	37	2	136567270	136567270	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr2:136567270C>T	uc002tuu.1	-	8	2658	c.2647G>A	c.(2647-2649)GTT>ATT	p.V883I		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	883	Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		TTTTCCCAAACGACTTTAGCC	0.502000													46	131					0	0	0.042209	0	0
TTN	7273	broad.mit.edu	37	2	179465605	179465605	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr2:179465605G>A	uc010zfg.1	-	237	48546	c.48322C>T	c.(48322-48324)CCC>TCC	p.P16108S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P9803S|TTN_uc010zfi.1_Missense_Mutation_p.P9736L|TTN_uc010zfj.1_Missense_Mutation_p.P9611L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17035							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAGTCACAGGGCCAACAGTG	0.448000													36	124					0	0	0.042209	0	0
SDPR	8436	broad.mit.edu	37	2	192711355	192711355	+	Silent	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr2:192711355C>T	uc002utb.2	-	1	627	c.297G>A	c.(295-297)AAG>AAA	p.K99K		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	99						caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	ACTTGGAGAGCTTGGTGAGGT	0.592000													21	52					0	0	0.055883	0	0
ANKRD44	91526	broad.mit.edu	37	2	197943464	197943464	+	Missense_Mutation	SNP	T	G	G			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr2:197943464T>G	uc002uua.1	-	16	1615	c.1538A>C	c.(1537-1539)TAT>TCT	p.Y513S	ANKRD44_uc002utz.3_Missense_Mutation_p.Y245S|ANKRD44_uc002uub.2_Missense_Mutation_p.Y538S|ANKRD44_uc010zgw.1_Missense_Mutation_p.Y466S	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	538	ANK 16.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			GGCGGCAGCATAATGTATGCT	0.413000													11	37					0	0	0.093190	0	0
PLCG1	5335	broad.mit.edu	37	20	39802384	39802384	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr20:39802384G>A	uc002xjp.1	+	29	3608	c.3487G>A	c.(3487-3489)GAG>AAG	p.E1163K	PLCG1_uc002xjo.1_Missense_Mutation_p.E1163K|PLCG1_uc010zwe.1_Missense_Mutation_p.E828K	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	1163	C2.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				CGTGGTGTATGAGGAAGACAT	0.517000											OREG0025953	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	54	121					0	0	0.048971	0	0
KRTAP21-2	337978	broad.mit.edu	37	21	32119504	32119504	+	Missense_Mutation	SNP	T	C	C	rs145167151		TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr21:32119504T>C	uc011adh.1	-	1	17	c.17A>G	c.(16-18)TAC>TGC	p.Y6C		NM_181617	NP_853648	Q3LI59	KR212_HUMAN	keratin associated protein 21-2	6						intermediate filament					0						GCAGTTTCTGTAGTAGTTGCA	0.229000													50	106					0	0	0.048971	0	0
ABCG1	9619	broad.mit.edu	37	21	43708163	43708163	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr21:43708163C>T	uc002zaq.2	+	9	1244	c.1138C>T	c.(1138-1140)CGA>TGA	p.R380*	ABCG1_uc002zan.2_Intron|ABCG1_uc002zam.2_Intron|ABCG1_uc002zao.2_Intron|ABCG1_uc002zap.2_Intron|ABCG1_uc002zar.2_Intron|ABCG1_uc011aev.1_Nonsense_Mutation_p.R391*|ABCG1_uc010gpb.1_Translation_Start_Site	NM_004915	NP_004906	P45844	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1	380	Cytoplasmic (Potential).				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			ovary(2)|central_nervous_system(1)	3					Adenosine triphosphate(DB00171)	GCAGACAAAACGATTAAAGGG	0.562000													22	181					0	0	0.055883	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091841	+	Missense_Mutation	DNP	TG	CA	CA	rs142470496	byFrequency	TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr22:29091840_29091841TG>CA	uc003adu.1	-	11	1188_1189	c.1116_1117CA>TG	c.(1114-1119)TCCAAG>TCTGAG	p.K373E	CHEK2_uc003ads.1_Missense_Mutation_p.K152E|CHEK2_uc010gvh.1_Missense_Mutation_p.K282E|CHEK2_uc010gvi.1_Intron|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Missense_Mutation_p.K416E|CHEK2_uc003adv.1_Missense_Mutation_p.K344E|CHEK2_uc003adw.1_Missense_Mutation_p.K373E|CHEK2_uc003adx.1_Missense_Mutation_p.K152E|CHEK2_uc003ady.1_Missense_Mutation_p.K373E|CHEK2_uc003adz.1_Missense_Mutation_p.K177E	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	373	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(2)|p.S372S(1)		central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						CCCAAAATCTTGGAGTGCCCAA	0.416000			F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				3	94					0	0	0.004672	0	0
PDGFRA	5156	broad.mit.edu	37	4	55161298	55161298	+	Missense_Mutation	SNP	G	C	C			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr4:55161298G>C	uc003han.3	+	23	3460	c.3129G>C	c.(3127-3129)CAG>CAC	p.Q1043H	PDGFRA_uc003haa.2_Missense_Mutation_p.Q803H	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	1043	Ser-rich.|Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CCAGCTCGCAGACCTCTGAAG	0.507000			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			5	129					0	0	0.029380	0	0
GK2	2712	broad.mit.edu	37	4	80328975	80328975	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr4:80328975C>T	uc003hlu.2	-	1	398	c.380G>A	c.(379-381)AGT>AAT	p.S127N		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	127					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						AATTTTTTTACTAAGATCCTC	0.428000													58	158					0	0	0.048971	0	0
CAMK2D	817	broad.mit.edu	37	4	114680566	114680566	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr4:114680566C>T	uc003ibi.2	-	2	929	c.70G>A	c.(70-72)GCA>ACA	p.A24T	CAMK2D_uc003ibj.2_Missense_Mutation_p.A24T|CAMK2D_uc003ibk.2_Missense_Mutation_p.A24T|CAMK2D_uc003ibo.3_Missense_Mutation_p.A24T|CAMK2D_uc003ibm.2_Missense_Mutation_p.A24T|CAMK2D_uc003ibn.2_Missense_Mutation_p.A24T|CAMK2D_uc003ibl.2_Missense_Mutation_p.A24T	NM_001221	NP_001212	Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II	24	ATP (By similarity).|Protein kinase.				interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		ACTGAGAATGCCCCCCTGGAA	0.318000													4	151					0	0	0.009096	0	0
FGA	2243	broad.mit.edu	37	4	155505774	155505774	+	Silent	SNP	G	A	A	rs148411201		TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr4:155505774G>A	uc003iod.1	-	6	2161	c.2103C>T	c.(2101-2103)GAC>GAT	p.D701D		NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	701	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	CTTCCCCCTCGTCATTCAGGC	0.493000													4	139					0	0	0.014758	0	0
BASP1	10409	broad.mit.edu	37	5	17275508	17275508	+	Silent	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr5:17275508C>T	uc003jfx.2	+	2	362	c.183C>T	c.(181-183)GAC>GAT	p.D61D		NM_006317	NP_006308	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein	61					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding				0						CCGACCAGGACGCCGAGGGCA	0.736000													3	6					0	0	0.009096	0	0
CDH9	1007	broad.mit.edu	37	5	26881407	26881407	+	Silent	SNP	T	G	G			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr5:26881407T>G	uc003jgs.1	-	12	2377	c.2208A>C	c.(2206-2208)GCA>GCC	p.A736A	CDH9_uc011cnv.1_Silent_p.A329A	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	736	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						AGGCATACGTTGCCAGCGAAT	0.418000													63	126					0	0	0.048971	0	0
Unknown	0	broad.mit.edu	37	5	28927196	28927196	+	RNA	SNP	G	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr5:28927196G>A	uc003jgz.1	+	1		c.220G>A								Homo sapiens similar to Striatin, mRNA (cDNA clone MGC:150339 IMAGE:40119616), complete cds.																		GAAGGATCTCGTGAGGATGAT	0.453000													12	38					0	0	0.093190	0	0
EGFLAM	133584	broad.mit.edu	37	5	38427311	38427311	+	Missense_Mutation	SNP	G	A	A	rs147520523	byFrequency	TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr5:38427311G>A	uc003jlc.1	+	14	2335	c.2011G>A	c.(2011-2013)GTG>ATG	p.V671M	EGFLAM_uc003jlb.1_Missense_Mutation_p.V671M|EGFLAM_uc003jle.1_Missense_Mutation_p.V437M|EGFLAM_uc003jlf.1_Missense_Mutation_p.V37M	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	671	Laminin G-like 2.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					AGGGGGCCACGTGGAGTTCCG	0.522000													6	222					0	0	0.021553	0	0
ZNF366	167465	broad.mit.edu	37	5	71756221	71756221	+	Missense_Mutation	SNP	A	G	G			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr5:71756221A>G	uc003kce.1	-	2	1289	c.1103T>C	c.(1102-1104)GTG>GCG	p.V368A		NM_152625	NP_689838	Q8N895	ZN366_HUMAN	zinc finger protein 366	368	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		GCCGCACTCCACACAGATGTT	0.657000													11	41					0	0	0.080935	0	0
LOC100133050	100133050	broad.mit.edu	37	5	99715528	99715528	+	RNA	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr5:99715528C>T	uc011cuw.1	-	4		c.382G>A				NR_027503				Homo sapiens glucuronidase, beta pseudogene (LOC100133050), non-coding RNA.												0						AGCGGACAGTCGAAGCCCTTC	0.607000													4	9					0	0	0.009096	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142526856	142526856	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr5:142526856G>A	uc011dbj.1	+	20	1933	c.1898G>A	c.(1897-1899)AGC>AAC	p.S633N	ARHGAP26_uc003lmt.2_Missense_Mutation_p.S633N|ARHGAP26_uc003lmw.2_Missense_Mutation_p.S633N	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal	633	Ser-rich.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AATCCAAACAGCATCCTTAAT	0.473000													45	109					0	0	0.045515	0	0
PLG	5340	broad.mit.edu	37	6	161152837	161152837	+	Missense_Mutation	SNP	C	T	T	rs140970354	byFrequency	TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr6:161152837C>T	uc003qtm.3	+	12	1562	c.1499C>T	c.(1498-1500)ACG>ATG	p.T500M		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	500	Kringle 5.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GTTACTGGGACGCCATGCCAG	0.507000													52	118					0	0	0.048971	0	0
DNAH11	8701	broad.mit.edu	37	7	21730409	21730409	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr7:21730409C>T	uc003svc.2	+	36	6003	c.5972C>T	c.(5971-5973)ACA>ATA	p.T1991I		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1991	AAA 1 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GAAGCTATCACACTGAAGCCA	0.363000									Kartagener_syndrome				6	325					0	0	0.021553	0	0
DNAH11	8701	broad.mit.edu	37	7	21742356	21742356	+	Missense_Mutation	SNP	T	C	C			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr7:21742356T>C	uc003svc.2	+	38	6261	c.6230T>C	c.(6229-6231)ATT>ACT	p.I2077T		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2077	AAA 1 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CTTCGTGCTATTAAGTCTGTC	0.388000									Kartagener_syndrome				10	39					0	0	0.024245	0	0
MGAM	8972	broad.mit.edu	37	7	141736692	141736692	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr7:141736692C>T	uc003vwy.2	+	18	2200	c.2146C>T	c.(2146-2148)CGC>TGC	p.R716C		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	716	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CCTTAACATCCGCTATACTCT	0.532000													93	302					0	0	0.048971	0	0
ADAM7	8756	broad.mit.edu	37	8	24350112	24350112	+	Splice_Site	SNP	T	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr8:24350112T>A	uc003xeb.2	+	15	1768	c.1655_splice	c.e15+2	p.K552_splice	ADAM7_uc003xec.2_Splice_Site_p.K324_splice	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7						proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		TGAGGAGAAGTAAGTGCCCTG	0.373000													22	56					0	0	0.091800	0	0
ADAM7	8756	broad.mit.edu	37	8	24350563	24350563	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr8:24350563A>T	uc003xeb.2	+	16	1776	c.1663A>T	c.(1663-1665)AGA>TGA	p.R555*	ADAM7_uc003xec.2_Nonsense_Mutation_p.R327*	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	555	Extracellular (Potential).|Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		CAGAGATGTCAGATGTGGAAA	0.448000													12	62					0	0	0.105934	0	0
MTERFD1	51001	broad.mit.edu	37	8	97256197	97256197	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr8:97256197C>T	uc003yhs.1	-	7	1087	c.1009G>A	c.(1009-1011)GTG>ATG	p.V337M	MTERFD1_uc003yhr.1_Missense_Mutation_p.V216M|MTERFD1_uc010mbd.1_Missense_Mutation_p.V337M	NM_015942	NP_057026	Q96E29	MTER1_HUMAN	MTERF domain containing 1 precursor	337					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion	transcription regulatory region DNA binding			ovary(1)	1	Breast(36;5.16e-05)					ACATTGTGCACAAAATCAAAC	0.403000													27	83					0	0	0.099896	0	0
EFR3A	23167	broad.mit.edu	37	8	132971845	132971845	+	Missense_Mutation	SNP	C	G	G			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr8:132971845C>G	uc003yte.2	+	8	991	c.790C>G	c.(790-792)CAC>GAC	p.H264D		NM_015137	NP_055952	Q14156	EFR3A_HUMAN	EFR3 homolog A	264						plasma membrane	binding			ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			TTTAGATCATCACAAACTGTG	0.284000													21	68					0	0	0.069288	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18777565	18777565	+	Missense_Mutation	SNP	T	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr9:18777565T>A	uc003zne.3	+	19	3465	c.3338T>A	c.(3337-3339)CTG>CAG	p.L1113Q		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	1113						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		CGCAGCCACCTGGAGCACCAG	0.647000													5	13					0	0	0.021553	0	0
ALDH1B1	219	broad.mit.edu	37	9	38396064	38396064	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr9:38396064C>T	uc004aay.2	+	2	431	c.319C>T	c.(319-321)CGC>TGC	p.R107C		NM_000692	NP_000683	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1B1 precursor	107					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			skin(1)	1				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	GCTGCTGAACCGCCTGGCAGA	0.632000													39	108					0	0	0.039052	0	0
CDK5RAP2	55755	broad.mit.edu	37	9	123152041	123152041	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr9:123152041C>T	uc004bkf.2	-	37	5784	c.5603G>A	c.(5602-5604)CGG>CAG	p.R1868Q	CDK5RAP2_uc010mvi.2_Missense_Mutation_p.R877Q|CDK5RAP2_uc004bke.2_Missense_Mutation_p.R1153Q|CDK5RAP2_uc004bkg.2_Missense_Mutation_p.R1789Q|CDK5RAP2_uc011lxw.1_Missense_Mutation_p.R1133Q|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Missense_Mutation_p.R1133Q|CDK5RAP2_uc011lya.1_Missense_Mutation_p.R1133Q	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1868	Interaction with PCNT and AKAP9.|Required for centrosomal attachment, Golgi localization and CALM1 interaction.				brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						TCTGGCCTTCCGAAGGATTTT	0.517000													6	61					0	0	0.021553	0	0
PNPLA7	375775	broad.mit.edu	37	9	140409907	140409907	+	Silent	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr9:140409907C>T	uc004cnf.2	-	11	1411	c.1074G>A	c.(1072-1074)GCG>GCA	p.A358A	PNPLA7_uc011mfa.1_Silent_p.A90A|PNPLA7_uc010ncj.1_Silent_p.A383A	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	358					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		GAATGGAAGGCGCGGGGACGG	0.657000													3	9					0	0	0.004672	0	0
DDX3X	1654	broad.mit.edu	37	X	41204458	41204458	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chrX:41204458C>T	uc004dfe.2	+	11	1906	c.1051C>T	c.(1051-1053)CGG>TGG	p.R351W	DDX3X_uc004dff.2_Missense_Mutation_p.R351W|DDX3X_uc011mkq.1_Missense_Mutation_p.R335W|DDX3X_uc011mkr.1_Missense_Mutation_p.R351W|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_RNA|DDX3X_uc011mkt.1_RNA	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	351	Necessary for interaction with XPO1.|Helicase ATP-binding.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						TGAAGCTGATCGGATGTTGGA	0.408000										HNSCC(61;0.18)			60	49					0	0	0.048971	0	0
RGAG1	57529	broad.mit.edu	37	X	109695334	109695334	+	Missense_Mutation	SNP	A	T	T			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chrX:109695334A>T	uc004eor.1	+	3	1735	c.1489A>T	c.(1489-1491)ATG>TTG	p.M497L	RGAG1_uc011msr.1_Missense_Mutation_p.M497L	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	497										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						CTCTGGAAAGATGTCCACGCC	0.507000													66	62					0	0	0.048971	0	0
AGTR2	186	broad.mit.edu	37	X	115303726	115303726	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chrX:115303726G>A	uc004eqh.3	+	3	400	c.193G>A	c.(193-195)GTG>ATG	p.V65M		NM_000686	NP_000677	P50052	AGTR2_HUMAN	angiotensin II receptor, type 2	65	Helical; Name=1; (Potential).				behavior|blood vessel remodeling|brain development|G-protein signaling, coupled to cGMP nucleotide second messenger|intracellular protein kinase cascade|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of heart rate|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of nitric-oxide synthase activity|positive regulation of phosphoprotein phosphatase activity|positive regulation of vasodilation|regulation of systemic arterial blood pressure by circulatory renin-angiotensin		angiotensin type II receptor activity|receptor antagonist activity			ovary(2)|lung(1)	3						CAATATTGTCGTGGTTACACT	0.363000													5	141					0	0	0.021553	0	0
SMARCA1	6594	broad.mit.edu	37	X	128632026	128632026	+	Missense_Mutation	SNP	C	G	G			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chrX:128632026C>G	uc004eun.3	-	11	1413	c.1300G>C	c.(1300-1302)GAT>CAT	p.D434H	SMARCA1_uc004eup.3_Missense_Mutation_p.D434H|SMARCA1_uc011muk.1_Missense_Mutation_p.D434H|SMARCA1_uc011mul.1_Missense_Mutation_p.D434H	NM_003069	NP_003060	P28370	SMCA1_HUMAN	SWI/SNF-related matrix-associated	434					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			ovary(3)|skin(1)	4						ACATCAATATCTTTCATCAGG	0.308000													18	18					0	0	0.038395	0	0
PGAP3	93210	broad.mit.edu	37	17	37844245	37844245	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CS-4941-01A-01D-1468-08	TCGA-CS-4941-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	003ed478-ceca-4752-8ae4-4cf12e6844bd	56e3b45b-55fa-4b7e-8998-920c8125aab1	g.chr17:37844245delA	uc002hsj.2	-	1	66	c.23delT	c.(22-24)TTGfs	p.L8fs	ERBB2_uc002hsm.2_5'Flank|ERBB2_uc010cwa.2_5'Flank|PGAP3_uc010wej.1_Frame_Shift_Del_p.L8fs|PGAP3_uc002hsk.2_Frame_Shift_Del_p.L8fs|PGAP3_uc010cvz.2_Frame_Shift_Del_p.L8fs|ERBB2_uc002hsl.2_5'Flank	NM_033419	NP_219487	Q96FM1	PGAP3_HUMAN	per1-like domain containing 1 precursor	8					GPI anchor biosynthetic process	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	hydrolase activity, acting on ester bonds			upper_aerodigestive_tract(1)	1						TAGCAGGACCAACCGCGCCGC	0.672													2	4	---	---	---	---					
