Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AJAP1	55966	broad.mit.edu	37	1	4832380	4832380	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr1:4832380C>T	uc001alm.1	+	4	1339	c.958C>T	c.(958-960)CGG>TGG	p.R320W	AJAP1_uc001aln.2_Missense_Mutation_p.R320W	NM_001042478	NP_001035943	Q9UKB5	AJAP1_HUMAN	adherens junction associated protein 1	320	Targeting signals.|Cytoplasmic (Potential).				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		CAGCCACCAGCGGAAGACCAA	0.607													10	60					0	0	0.008291	0	0
CAMTA1	23261	broad.mit.edu	37	1	7796570	7796570	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr1:7796570C>T	uc001aoi.2	+	13	3440	c.3233C>T	c.(3232-3234)GCC>GTC	p.A1078V	CAMTA1_uc010nzv.1_Missense_Mutation_p.A165V|CAMTA1_uc001aok.3_Missense_Mutation_p.A121V|CAMTA1_uc001aoj.2_Missense_Mutation_p.A34V	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	1078	ANK 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CAGGGCTATGCCACCCTAATC	0.592													4	97					0	0	0.000602	0	0
SLC45A1	50651	broad.mit.edu	37	1	8390428	8390428	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr1:8390428C>T	uc001apb.2	+	4	875	c.875C>T	c.(874-876)CCG>CTG	p.P292L	SLC45A1_uc001apc.2_5'UTR	NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	292					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CCTGAGAGGCCGCTGCGGCCG	0.697													32	34					0	0	0.013726	0	0
CLSTN1	22883	broad.mit.edu	37	1	9794036	9794036	+	Missense_Mutation	SNP	A	C	C			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr1:9794036A>C	uc001aqh.2	-	15	3034	c.2275T>G	c.(2275-2277)TTC>GTC	p.F759V	CLSTN1_uc001aqi.2_Missense_Mutation_p.F749V|CLSTN1_uc010oag.1_Missense_Mutation_p.F740V|CLSTN1_uc001aqf.2_5'Flank	NM_001009566	NP_001009566	O94985	CSTN1_HUMAN	calsyntenin 1 isoform 1	759	Extracellular (Potential).				homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			skin(1)	1	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		TTACCTGTGAAGGTCATGCCC	0.612													16	78					0	0	0.007413	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12885059	12885059	+	Missense_Mutation	SNP	C	G	G	rs143004725	by1000genomes	TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr1:12885059C>G	uc001auk.2	-	4	1248	c.1052G>C	c.(1051-1053)TGC>TCC	p.C351S		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	351	LRR 6.										0						GGTGGCCATGCAGATGGGATT	0.532													4	294					0	0	0.006214	0	0
TRIT1	54802	broad.mit.edu	37	1	40318536	40318536	+	Missense_Mutation	SNP	C	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr1:40318536C>A	uc010oiz.1	-	4	441	c.427G>T	c.(427-429)GGC>TGC	p.G143C	TRIT1_uc001cec.3_RNA|TRIT1_uc001ced.3_Intron|TRIT1_uc001cee.3_Intron|TRIT1_uc001cef.3_Intron|TRIT1_uc001ceg.3_5'UTR|TRIT1_uc001ceh.3_Intron|TRIT1_uc009vvv.2_Missense_Mutation_p.G2C|TRIT1_uc001cei.3_Intron|TRIT1_uc001ceq.2_Intron|TRIT1_uc001cek.2_Intron|TRIT1_uc009vvx.2_Intron|TRIT1_uc001cel.2_Intron|TRIT1_uc001cem.2_Missense_Mutation_p.G63C|TRIT1_uc001cen.2_Intron|TRIT1_uc001ceo.2_Intron|TRIT1_uc001cep.2_Intron	NM_017646	NP_060116	Q9H3H1	MOD5_HUMAN	tRNA isopentenyltransferase 1 precursor	143					tRNA processing	mitochondrion	ATP binding|metal ion binding|tRNA dimethylallyltransferase activity			ovary(1)	1	all_cancers(7;4.55e-14)|all_lung(5;1.23e-16)|all_epithelial(6;2.17e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;3.29e-18)|Epithelial(16;3.07e-17)|all cancers(16;6.21e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TTCTCAGTGCCCATCTCCTGG	0.368													5	215					0.00116845	0.00169755	0.001168	1	0
SEP15	9403	broad.mit.edu	37	1	87369113	87369113	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr1:87369113C>A	uc010osi.1	-	2	416	c.103G>T	c.(103-105)GAG>TAG	p.E35*	SEP15_uc010osj.1_Nonsense_Mutation_p.E35*	NM_004261	NP_004252	O60613	SEP15_HUMAN	15 kDa selenoprotein isoform 1 precursor	32					'de novo' posttranslational protein folding	endoplasmic reticulum lumen	selenium binding				0		Lung NSC(277;0.153)		all cancers(265;0.00744)|Epithelial(280;0.0333)		GATGAAAACTCTGCCCCAAAA	0.418													11	19					2.68362e-12	4.26059e-12	0.013537	1	0
FLG	2312	broad.mit.edu	37	1	152284263	152284263	+	Silent	SNP	G	A	A	rs146128865	byFrequency	TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr1:152284263G>A	uc001ezu.1	-	3	3135	c.3099C>T	c.(3097-3099)CAC>CAT	p.H1033H	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1033	Filaggrin 6.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCGGGATCCGTGTCTTTCTC	0.567									Ichthyosis				167	669					0	0	0.014410	0	0
SPRR2G	6706	broad.mit.edu	37	1	153122438	153122438	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr1:153122438G>A	uc009wod.1	-	2	270	c.149C>T	c.(148-150)CCA>CTA	p.P50L		NM_001014291	NP_001014313	Q9BYE4	SPR2G_HUMAN	small proline-rich protein 2G	50					keratinization	cornified envelope|cytoplasm					0	all_lung(78;1.78e-30)|Lung NSC(65;7.29e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			ATCCTGGCATGGTGGAGGTGG	0.567													23	111					0	0	0.002780	0	0
ADAR	103	broad.mit.edu	37	1	154560602	154560602	+	Silent	SNP	G	A	A	rs151241634	byFrequency	TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr1:154560602G>A	uc001ffh.2	-	11	3218	c.3018C>T	c.(3016-3018)AAC>AAT	p.N1006N	ADAR_uc001ffj.2_Silent_p.N961N|ADAR_uc001ffi.2_Silent_p.N980N|ADAR_uc001ffk.2_Silent_p.N711N	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	1006	A to I editase.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		ATCACTCACCGTTCTCCACCT	0.478													10	402					0	0	0.008291	0	0
CD244	51744	broad.mit.edu	37	1	160811431	160811431	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr1:160811431C>A	uc009wtq.2	-	2	500	c.322G>T	c.(322-324)GAG>TAG	p.E108*	CD244_uc001fxa.2_Nonsense_Mutation_p.E108*|CD244_uc009wtp.2_RNA|CD244_uc009wtr.2_Nonsense_Mutation_p.E108*|CD244_uc010pjt.1_RNA	NM_016382	NP_057466	Q9BZW8	CD244_HUMAN	CD244 natural killer cell receptor 2B4	108	Extracellular (Potential).|Ig-like 1.				blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CTGGTGACCTCCAGGCAGTAG	0.453													22	90					4.26978e-12	6.70965e-12	0.003330	1	0
RXRG	6258	broad.mit.edu	37	1	165398112	165398112	+	Missense_Mutation	SNP	A	C	C			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr1:165398112A>C	uc001gda.2	-	2	441	c.141T>G	c.(139-141)GAT>GAG	p.D47E		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	47	Modulating (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	TCACTGGGGTATCTGTGTAGC	0.607													5	63					0	0	0.000602	0	0
SELE	6401	broad.mit.edu	37	1	169697059	169697059	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr1:169697059C>T	uc001ggm.3	-	9	1446	c.1289G>A	c.(1288-1290)TGC>TAC	p.C430Y	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	430	Extracellular (Potential).|Sushi 5.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					GACAGCATCGCATCTCACAGC	0.498													29	121					0	0	0.010818	0	0
EDEM3	80267	broad.mit.edu	37	1	184695449	184695449	+	Silent	SNP	T	C	C			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr1:184695449T>C	uc010pok.1	-	7	948	c.687A>G	c.(685-687)GCA>GCG	p.A229A	EDEM3_uc010pol.1_RNA|EDEM3_uc010pom.1_Silent_p.A229A|EDEM3_uc001gqy.2_Silent_p.A152A	NM_025191	NP_079467	Q9BZQ6	EDEM3_HUMAN	ER degradation enhancer, mannosidase alpha-like	229					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			skin(1)	1						TCAAGGTACCTGCACAAGCTG	0.388													11	57					0	0	0.003163	0	0
OBSCN	84033	broad.mit.edu	37	1	228404888	228404888	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr1:228404888C>T	uc009xez.1	+	8	2596	c.2552C>T	c.(2551-2553)ACG>ATG	p.T851M	OBSCN_uc001hsn.2_Missense_Mutation_p.T851M	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	851	Ig-like 8.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GATGTGGGGACGCGGCACCGG	0.652													14	106					0	0	0.004007	0	0
GPR137B	7107	broad.mit.edu	37	1	236341829	236341829	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr1:236341829C>T	uc001hxq.2	+	3	671	c.580C>T	c.(580-582)CGA>TGA	p.R194*	GPR137B_uc001hxr.1_5'UTR|GPR137B_uc009xge.2_RNA	NM_003272	NP_003263	O60478	G137B_HUMAN	G protein-coupled receptor 137B	194	Helical; (Potential).					integral to plasma membrane|membrane fraction					0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.197)|Prostate(94;0.219)|Acute lymphoblastic leukemia(190;0.226)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			CGTCTCTGTGCGAGTGGCCAT	0.478													58	164					0	0	0.014410	0	0
RYR2	6262	broad.mit.edu	37	1	237804239	237804239	+	Missense_Mutation	SNP	C	G	G			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr1:237804239C>G	uc001hyl.1	+	47	7278	c.7158C>G	c.(7156-7158)AAC>AAG	p.N2386K		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2386	Cytoplasmic (By similarity).|4 X approximate repeats.		N -> I (in ARVD2 and CPVT1).		cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACATGGGGAACGCGATCATGA	0.443													6	39					0	0	0.003080	0	0
LOC653544	653544	broad.mit.edu	37	10	135491112	135491112	+	Missense_Mutation	SNP	C	A	A	rs141602288	by1000genomes	TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr10:135491112C>A	uc010qvi.1	+	1	834	c.723C>A	c.(721-723)TTC>TTA	p.F241L		NM_001127389	NP_001120861	F5GZ66	F5GZ66_HUMAN	double homeobox, 4-like	241						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGGTCGCCTTCGCCCACACCG	0.776													3	34					0.000274275	0.000406138	0.004482	1	0
FOLH1	2346	broad.mit.edu	37	11	49207240	49207240	+	Silent	SNP	T	C	C			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr11:49207240T>C	uc001ngy.2	-	6	1068	c.807A>G	c.(805-807)ACA>ACG	p.T269T	FOLH1_uc001ngz.2_Silent_p.T269T|FOLH1_uc009yly.2_Silent_p.T254T|FOLH1_uc009ylz.2_Silent_p.T254T|FOLH1_uc009yma.2_Intron	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	269	Extracellular (Probable).	Calcium.			proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	GGTAACCTGGTGTGAGAGGGT	0.428													12	29					0	0	0.001855	0	0
OR5D14	219436	broad.mit.edu	37	11	55563532	55563532	+	Silent	SNP	G	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr11:55563532G>T	uc010rim.1	+	1	501	c.501G>T	c.(499-501)CGG>CGT	p.R167R		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	167	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				ATGCTCTCCGGTTAAACTTCT	0.502													34	163					6.05902e-23	9.71968e-23	0.003755	1	0
OR9G9	504191	broad.mit.edu	37	11	56468417	56468417	+	Missense_Mutation	SNP	A	G	G			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr11:56468417A>G	uc010rjn.1	+	1	554	c.554A>G	c.(553-555)AAG>AGG	p.K185R		NM_001013358	NP_001013376	P0C7N8	OR9G9_HUMAN	olfactory receptor, family 9, subfamily G,	185	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCCTTGGTGGAGCTGGCCTGT	0.463													30	112					0	0	0.007291	0	0
APOA1	335	broad.mit.edu	37	11	116707048	116707048	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr11:116707048C>T	uc001ppu.1	-	4	359	c.280G>A	c.(280-282)GAG>AAG	p.E94K	APOA1_uc001ppv.1_Missense_Mutation_p.E94K	NM_000039	NP_000030	P02647	APOA1_HUMAN	apolipoprotein A-I preproprotein	94	10 X approximate tandem repeats.|2.				Cdc42 protein signal transduction|cholesterol efflux|cholesterol homeostasis|cholesterol import|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|negative regulation of cytokine secretion involved in immune response|negative regulation of interleukin-1 beta secretion|negative regulation of very-low-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|phospholipid efflux|platelet activation|platelet degranulation|positive regulation of cholesterol esterification|positive regulation of hydrolase activity|protein stabilization|reverse cholesterol transport	endocytic vesicle|endoplasmic reticulum lumen|plasma membrane|spherical high-density lipoprotein particle|stored secretory granule|very-low-density lipoprotein particle	apolipoprotein A-I receptor binding|beta-amyloid binding|cholesterol binding|cholesterol transporter activity|enzyme binding|high-density lipoprotein particle receptor binding|identical protein binding|phosphatidylcholine-sterol O-acyltransferase activator activity|phospholipid binding				0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.59e-05)|all cancers(92;0.000162)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		TCCCAGAACTCCTGGGTCACA	0.592													23	81					0	0	0.012319	0	0
IRAK3	11213	broad.mit.edu	37	12	66638280	66638280	+	Missense_Mutation	SNP	T	C	C			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr12:66638280T>C	uc001sth.2	+	9	1004	c.902T>C	c.(901-903)TTG>TCG	p.L301S	IRAK3_uc010ssy.1_Missense_Mutation_p.L240S	NM_007199	NP_009130	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	301	Protein kinase.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(2)|central_nervous_system(1)	8				GBM - Glioblastoma multiforme(28;0.0203)		AACATCCTTTTGGATGATCAG	0.393													16	50					0	0	0.006122	0	0
KERA	11081	broad.mit.edu	37	12	91449807	91449807	+	Silent	SNP	T	C	C			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr12:91449807T>C	uc001tbl.2	-	2	871	c.252A>G	c.(250-252)GAA>GAG	p.E84E		NM_007035	NP_008966	O60938	KERA_HUMAN	keratocan precursor	84	LRR 1.				response to stimulus|visual perception	proteinaceous extracellular matrix				skin(1)	1						CAGGAATGGTTTCTATCAGGT	0.348													13	73					0	0	0.013537	0	0
TMCC3	57458	broad.mit.edu	37	12	94975589	94975589	+	Silent	SNP	G	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr12:94975589G>A	uc001tdj.2	-	2	922	c.804C>T	c.(802-804)AAC>AAT	p.N268N	TMCC3_uc001tdi.2_Silent_p.N237N	NM_020698	NP_065749	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	268						integral to membrane				ovary(1)|skin(1)	2						ACTGGTTTCCGTTACTGTCGG	0.592													24	93					0	0	0.002780	0	0
ATP8A2	51761	broad.mit.edu	37	13	26411309	26411309	+	Silent	SNP	C	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr13:26411309C>A	uc001uqk.2	+	29	2905	c.2763C>A	c.(2761-2763)ACC>ACA	p.T921T	ATP8A2_uc010tdi.1_Silent_p.T856T|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Silent_p.T471T	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	881	Helical; (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		AGATTTTCACCGCTTTGCCGC	0.498													52	105					2.83923e-41	4.6515e-41	0.014410	1	0
MYO16	23026	broad.mit.edu	37	13	109318372	109318372	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr13:109318372G>A	uc001vqt.1	+	2	227	c.101G>A	c.(100-102)CGC>CAC	p.R34H	MYO16_uc010agk.1_Missense_Mutation_p.R56H	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	34					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TACTATGAGCGCGAGAAGGCT	0.527													14	42					0	0	0.001855	0	0
CASC5	57082	broad.mit.edu	37	15	40914116	40914116	+	Missense_Mutation	SNP	T	C	C			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr15:40914116T>C	uc010bbs.1	+	11	1893	c.1732T>C	c.(1732-1734)TCA>CCA	p.S578P	CASC5_uc010ucq.1_Missense_Mutation_p.S402P|CASC5_uc001zme.2_Missense_Mutation_p.S552P|CASC5_uc010bbt.1_Missense_Mutation_p.S552P	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	578	Interaction with BUB1 and BUB1B.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		GCAGAGCCTGTCAAATCCTTT	0.358													10	48					0	0	0.010729	0	0
TUBGCP4	27229	broad.mit.edu	37	15	43695930	43695930	+	Missense_Mutation	SNP	C	T	T	rs149549954	by1000genomes	TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr15:43695930C>T	uc001zro.2	+	16	2024	c.1784C>T	c.(1783-1785)TCG>TTG	p.S595L	TUBGCP4_uc001zrn.2_Missense_Mutation_p.S594L|TUBGCP4_uc010bdh.2_RNA	NM_014444	NP_055259	Q9UGJ1	GCP4_HUMAN	tubulin, gamma complex associated protein 4	595					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	structural constituent of cytoskeleton			ovary(3)	3		all_cancers(109;1.27e-10)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.72e-06)|all_lung(180;1.59e-05)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;3.53e-07)		AGTTTTTGTTCGCTGGTCAGT	0.527													22	21					0	0	0.003330	0	0
AP4E1	23431	broad.mit.edu	37	15	51260560	51260560	+	Missense_Mutation	SNP	T	G	G			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr15:51260560T>G	uc001zyx.1	+	15	1982	c.1952T>G	c.(1951-1953)CTT>CGT	p.L651R		NM_007347	NP_031373	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1	651					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity				0				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		GAGGAAAAGCTTTCTCAGGAA	0.373													6	14					0	0	0.001984	0	0
ACSM1	116285	broad.mit.edu	37	16	20635526	20635526	+	Silent	SNP	G	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr16:20635526G>A	uc002dhm.1	-	12	1607	c.1539C>T	c.(1537-1539)GCC>GCT	p.A513A	ACSM1_uc002dhn.1_RNA|ACSM1_uc010bwg.1_Silent_p.A513A	NM_052956	NP_443188	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member	513					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|skin(1)	2						GGACAATAAAGGCCTTCACCA	0.473													21	69					0	0	0.014323	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77401350	77401350	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr16:77401350G>A	uc002ffc.3	-	4	1185	c.766C>T	c.(766-768)CGA>TGA	p.R256*	ADAMTS18_uc002ffe.1_Translation_Start_Site|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	256	Cysteine switch (By similarity).				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						TTCTTGCGTCGTCCACAAAAA	0.443													18	72					0	0	0.010504	0	0
FAM92B	339145	broad.mit.edu	37	16	85132864	85132864	+	Missense_Mutation	SNP	A	C	C			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr16:85132864A>C	uc010vok.1	-	8	998	c.842T>G	c.(841-843)GTA>GGA	p.V281G		NM_198491	NP_940893	Q6ZTR7	FA92B_HUMAN	hypothetical protein LOC339145	281										central_nervous_system(1)	1						CCCCTTAACCACCCACTCACA	0.318													7	71					0	0	0.010504	0	0
DNAH2	146754	broad.mit.edu	37	17	7643864	7643864	+	Silent	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr17:7643864C>T	uc002giu.1	+	9	1517	c.1503C>T	c.(1501-1503)CGC>CGT	p.R501R	DNAH2_uc002git.2_Silent_p.R583R|DNAH2_uc010vuk.1_Silent_p.R501R	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	501	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TTGCCTCCCGCGAGGTGCGGC	0.672													17	112					0	0	0.007413	0	0
DNAJC7	7266	broad.mit.edu	37	17	40140910	40140910	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr17:40140910G>A	uc002hyo.2	-	8	995	c.758C>T	c.(757-759)GCC>GTC	p.A253V	DNAJC7_uc010cxu.2_Missense_Mutation_p.A197V|DNAJC7_uc010cxv.2_Missense_Mutation_p.A197V|DNAJC7_uc010wgb.1_Missense_Mutation_p.A197V|DNAJC7_uc010wgc.1_Missense_Mutation_p.A111V|DNAJC7_uc002hyp.2_Missense_Mutation_p.A197V|DNAJC7_uc010cxw.2_RNA	NM_003315	NP_003306	Q99615	DNJC7_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 7	253					chaperone cofactor-dependent protein refolding	cytoplasm|cytoskeleton|nucleus	heat shock protein binding|unfolded protein binding			ovary(1)	1		all_cancers(22;0.00273)|Breast(137;0.00104)|all_epithelial(22;0.0305)				GAGTGCTTTGGCATTCTACAG	0.423													51	84					0	0	0.014410	0	0
CSHL1	1444	broad.mit.edu	37	17	61987091	61987091	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr17:61987091C>T	uc002jda.1	-	5	711	c.649G>A	c.(649-651)GAG>AAG	p.E217K	CSHL1_uc002jcz.1_Missense_Mutation_p.E194K|CSHL1_uc002jdb.1_Missense_Mutation_p.E123K|CSHL1_uc002jdc.1_Missense_Mutation_p.E134K|CSHL1_uc002jdd.1_Missense_Mutation_p.E155K|CSHL1_uc002jde.2_3'UTR|CSHL1_uc002jdf.2_3'UTR|CSHL1_uc002jdg.2_3'UTR|CSHL1_uc002jdh.2_3'UTR	NM_022579	NP_072101	Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	217						extracellular region	hormone activity|metal ion binding				0						CAGCTGCCCTCCACAGAGCGG	0.632													41	65					0	0	0.006999	0	0
LGALS3BP	3959	broad.mit.edu	37	17	76967757	76967757	+	Silent	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr17:76967757C>T	uc002jwh.2	-	6	1838	c.1659G>A	c.(1657-1659)TCG>TCA	p.S553S	LGALS3BP_uc002jwi.2_Silent_p.S359S|LGALS3BP_uc010dhr.2_Silent_p.S359S	NM_005567	NP_005558	Q08380	LG3BP_HUMAN	galectin 3 binding protein	553					cell adhesion|cellular defense response	extracellular space|membrane|proteinaceous extracellular matrix	protein binding|scavenger receptor activity			central_nervous_system(3)|ovary(1)	4			BRCA - Breast invasive adenocarcinoma(99;0.0677)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			AGGTGCTCTTCGAGCTGTTGG	0.612											OREG0024787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	43					0	0	0.003330	0	0
LAMA3	3909	broad.mit.edu	37	18	21489195	21489195	+	Missense_Mutation	SNP	A	G	G			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr18:21489195A>G	uc002kuq.2	+	55	7180	c.7094A>G	c.(7093-7095)AAC>AGC	p.N2365S	LAMA3_uc002kur.2_Missense_Mutation_p.N2309S|LAMA3_uc002kus.3_Missense_Mutation_p.N756S|LAMA3_uc002kut.3_Missense_Mutation_p.N700S	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2365	Domain II and I.|Potential.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCCTTGGGAAACATCTCTGAC	0.453													13	69					0	0	0.013537	0	0
KIAA1012	22878	broad.mit.edu	37	18	29433858	29433858	+	Missense_Mutation	SNP	G	C	C			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr18:29433858G>C	uc002kxc.3	-	22	3751	c.3387C>G	c.(3385-3387)AGC>AGG	p.S1129R	KIAA1012_uc002kxb.3_Missense_Mutation_p.S1075R|KIAA1012_uc002kxd.3_RNA	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	1129					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						TCCAGTGTTTGCTACTACTTG	0.328													9	36					0	0	0.006214	0	0
SERPINB11	89778	broad.mit.edu	37	18	61387343	61387343	+	Missense_Mutation	SNP	A	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr18:61387343A>T	uc002ljk.3	+	7	634	c.572A>T	c.(571-573)AAA>ATA	p.K191I	SERPINB11_uc010xes.1_Missense_Mutation_p.K16I|SERPINB11_uc010dqd.2_Missense_Mutation_p.K77I|SERPINB11_uc002ljj.3_Missense_Mutation_p.K77I|SERPINB11_uc010dqe.2_Intron|SERPINB11_uc010dqf.2_Intron	NM_080475	NP_536723	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B, member 11	191					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)	1		Esophageal squamous(42;0.129)				TGGCAAAATAAATTTCAAGTA	0.348													8	33					0	0	0.004482	0	0
S1PR2	9294	broad.mit.edu	37	19	10334891	10334891	+	Silent	SNP	G	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr19:10334891G>A	uc002mnl.2	-	2	802	c.691C>T	c.(691-693)CTG>TTG	p.L231L		NM_004230	NP_004221	O95136	S1PR2_HUMAN	endothelial differentiation, sphingolipid	231	Cytoplasmic (By similarity).				activation of MAPK activity|positive regulation of cell proliferation	integral to membrane|plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|central_nervous_system(1)	2						GTCTTGAGCAGGGCTAGCGTC	0.617													14	32					0	0	0.002450	0	0
ZNF585B	92285	broad.mit.edu	37	19	37676803	37676803	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr19:37676803C>T	uc002ofq.2	-	5	1890	c.1636G>A	c.(1636-1638)GGA>AGA	p.G546R	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Missense_Mutation_p.G360R	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	546					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGTCTCTCTCCAGTGTGAATT	0.383													16	81					0	0	0.007413	0	0
FCGBP	8857	broad.mit.edu	37	19	40368357	40368357	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr19:40368357C>T	uc002omp.3	-	28	12999	c.12991G>A	c.(12991-12993)GCC>ACC	p.A4331T		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4331						extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCCTGGCAGGCGGCCACGTAG	0.647													30	260					0	0	0.010818	0	0
PTH2	113091	broad.mit.edu	37	19	49926533	49926533	+	Missense_Mutation	SNP	G	C	C			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr19:49926533G>C	uc002pnn.1	-	1	166	c.64C>G	c.(64-66)CTG>GTG	p.L22V		NM_178449	NP_848544	Q96A98	TIP39_HUMAN	parathyroid hormone 2 preproprotein	22					neuropeptide signaling pathway	extracellular region					0				OV - Ovarian serous cystadenocarcinoma(262;0.0015)|GBM - Glioblastoma multiforme(486;0.044)|Lung(386;0.0785)|LUSC - Lung squamous cell carcinoma(496;0.0836)		GGCACCACcagcagcagcagc	0.597													3	42					0	0	0.001168	0	0
NLRP12	91662	broad.mit.edu	37	19	54299148	54299148	+	Silent	SNP	C	G	G			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr19:54299148C>G	uc002qch.3	-	9	3283	c.3063G>C	c.(3061-3063)CGG>CGC	p.R1021R	NLRP12_uc010eqw.2_Silent_p.R247R|NLRP12_uc002qci.3_Silent_p.R964R|NLRP12_uc002qcj.3_Silent_p.R1022R|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Intron	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	1021					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		GATGGCTCAGCCGCTTGCAAA	0.557													5	38					0	0	0.000602	0	0
BCL11A	53335	broad.mit.edu	37	2	60679728	60679728	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr2:60679728C>T	uc010ypj.1	-	4	2582	c.2354G>A	c.(2353-2355)CGA>CAA	p.R785Q	BCL11A_uc002sab.2_Silent_p.S768S|BCL11A_uc002sac.2_Missense_Mutation_p.R235Q|BCL11A_uc010ypi.1_Silent_p.S437S	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	Error:Variant_position_missing_in_Q9H165_after_alignment					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TAAGGGCTCTCGAGCTTCCAT	0.557			T	IGH@	B-CLL								34	105					0	0	0.003755	0	0
RND3	390	broad.mit.edu	37	2	151326607	151326607	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr2:151326607G>A	uc002txe.2	-	5	873	c.629C>T	c.(628-630)TCA>TTA	p.S210L	RND3_uc002txf.2_Missense_Mutation_p.S209L|RND3_uc002txg.2_Missense_Mutation_p.S210L|RND3_uc010zbv.1_Intron|RND3_uc010zbw.1_Missense_Mutation_p.S73L	NM_005168	NP_005159	P61587	RND3_HUMAN	ras homolog gene family, member E precursor	210					actin cytoskeleton organization|cell adhesion|small GTPase mediated signal transduction	Golgi membrane	GTP binding|GTPase activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.106)		GGCTCTCTGTGATTTGTTCCG	0.458													31	108					0	0	0.010818	0	0
ZDBF2	57683	broad.mit.edu	37	2	207169761	207169761	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr2:207169761C>T	uc002vbp.2	+	5	759	c.509C>T	c.(508-510)GCT>GTT	p.A170V		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	170							nucleic acid binding|zinc ion binding			ovary(3)	3						ATTGGTCAGGCTACAAATAAT	0.423													10	36					0	0	0.006214	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 								15	61					0	0	0.004990	0	0
SP100	6672	broad.mit.edu	37	2	231367785	231367785	+	Silent	SNP	A	G	G			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr2:231367785A>G	uc002vqt.2	+	20	1866	c.1725A>G	c.(1723-1725)AGA>AGG	p.R575R	SP100_uc002vqs.2_Silent_p.R575R|SP100_uc002vqu.1_Silent_p.R575R|SP100_uc010fxp.1_5'Flank	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2	575	Nuclear localization signal (Potential).				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TCTCAGGAAGAAAAGCCAACA	0.289													18	82					0	0	0.008871	0	0
PCSK2	5126	broad.mit.edu	37	20	17446133	17446133	+	Missense_Mutation	SNP	G	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr20:17446133G>T	uc002wpm.2	+	11	1685	c.1365G>T	c.(1363-1365)ATG>ATT	p.M455I	PCSK2_uc002wpl.2_Missense_Mutation_p.M436I|PCSK2_uc010zrm.1_Missense_Mutation_p.M420I|PCSK2_uc002wpn.2_Missense_Mutation_p.M109I	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	455					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGGTGAAAATGGCTAAAGACT	0.567													7	45					1.26484e-09	1.94786e-09	0.003080	1	0
BSN	8927	broad.mit.edu	37	3	49691512	49691512	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr3:49691512C>T	uc003cxe.3	+	5	4637	c.4523C>T	c.(4522-4524)ACG>ATG	p.T1508M		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1508					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		TCTACACAGACGCCAAGTCCA	0.622													11	67					0	0	0.008291	0	0
BSN	8927	broad.mit.edu	37	3	49694614	49694614	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr3:49694614C>T	uc003cxe.3	+	5	7739	c.7625C>T	c.(7624-7626)ACG>ATG	p.T2542M		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	2542					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		TCACTGCAAACGGAGGAGCAG	0.632													14	40					0	0	0.001855	0	0
CISH	1154	broad.mit.edu	37	3	50645154	50645154	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr3:50645154G>A	uc003dax.2	-	3	842	c.661C>T	c.(661-663)CGC>TGC	p.R221C	CISH_uc010hlq.2_Missense_Mutation_p.R238C	NM_145071	NP_659508	Q9NSE2	CISH_HUMAN	cytokine-inducible SH2-containing protein	221	SOCS box.				intracellular signal transduction|negative regulation of signal transduction|regulation of cell growth	intracellular					0				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		TGCAGGCTGCGGGCACTGCTT	0.622													23	97					0	0	0.003330	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54596855	54596855	+	Missense_Mutation	SNP	G	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr3:54596855G>T	uc003dhf.2	+	6	621	c.573G>T	c.(571-573)TGG>TGT	p.W191C	CACNA2D3_uc011beu.1_RNA|CACNA2D3_uc003dhg.1_Missense_Mutation_p.W97C|CACNA2D3_uc003dhh.1_RNA|CACNA2D3_uc010hmv.1_5'UTR	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	191	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		GGGTTTATTGGTCTGAATCTC	0.403													10	38					1.76689e-08	2.66766e-08	0.006214	1	0
SDHAP2	727956	broad.mit.edu	37	3	195400788	195400788	+	Silent	SNP	G	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr3:195400788G>A	uc003fuw.2	+	9	1278	c.84G>A	c.(82-84)GGG>GGA	p.G28G	SDHAP2_uc011btb.1_Missense_Mutation_p.A176T|SDHAP2_uc011btc.1_RNA|SDHAP2_uc003fuv.2_RNA					SubName: Full=cDNA FLJ16373 fis, clone THYMU3000269, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						CCGCCTCGGGGCAAACTCGCT	0.602													3	26					0	0	0.001168	0	0
SEL1L3	23231	broad.mit.edu	37	4	25849135	25849135	+	Missense_Mutation	SNP	T	C	C			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr4:25849135T>C	uc003gru.3	-	2	666	c.514A>G	c.(514-516)ATA>GTA	p.I172V		NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3	172						integral to membrane	binding				0						GCGCGTACTATCACTGCAGAT	0.408													9	65					0	0	0.004482	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73188757	73188757	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr4:73188757G>A	uc003hgk.1	-	6	956	c.919C>T	c.(919-921)CGC>TGC	p.R307C		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	307	Peptidase M12B.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			ATTATCATGCGCACCAGGACC	0.363													7	317					0	0	0.004482	0	0
SHROOM3	57619	broad.mit.edu	37	4	77661578	77661578	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr4:77661578C>T	uc011cbx.1	+	5	3205	c.2252C>T	c.(2251-2253)CCG>CTG	p.P751L	SHROOM3_uc011cbz.1_Missense_Mutation_p.P575L|SHROOM3_uc003hkf.1_Missense_Mutation_p.P626L|SHROOM3_uc003hkg.2_Missense_Mutation_p.P529L	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	751					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			CCCTCGCACCCGCACACATCC	0.692													5	32					0	0	0.001168	0	0
FRAS1	80144	broad.mit.edu	37	4	79400621	79400621	+	Missense_Mutation	SNP	T	G	G			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr4:79400621T>G	uc003hlb.2	+	56	8632	c.8192T>G	c.(8191-8193)TTT>TGT	p.F2731C		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2726	Extracellular (Potential).|Calx-beta 2.				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						GGCTCTGATTTTAAATCTAGA	0.463													15	39					0	0	0.002450	0	0
USP53	54532	broad.mit.edu	37	4	120214081	120214081	+	Missense_Mutation	SNP	T	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr4:120214081T>A	uc003ics.3	+	18	4003	c.2937T>A	c.(2935-2937)GAT>GAA	p.D979E	USP53_uc003icr.3_Missense_Mutation_p.D979E|USP53_uc003icu.3_Missense_Mutation_p.D602E	NM_019050	NP_061923	Q70EK8	UBP53_HUMAN	ubiquitin specific protease 53	979					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			ovary(1)|breast(1)|kidney(1)|skin(1)	4						ATATGAATGATGAAAGACATA	0.393													9	49					0	0	0.004482	0	0
PRDM5	11107	broad.mit.edu	37	4	121698363	121698363	+	Missense_Mutation	SNP	A	C	C			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr4:121698363A>C	uc003idn.2	-	13	1767	c.1517T>G	c.(1516-1518)GTT>GGT	p.V506G	PRDM5_uc003ido.2_Missense_Mutation_p.V475G|PRDM5_uc010ine.2_Missense_Mutation_p.V475G	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	506	C2H2-type 12.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2						CCGGATATGAACTCTGAGTGT	0.383													32	129					0	0	0.003271	0	0
GMDS	2762	broad.mit.edu	37	6	1726688	1726688	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr6:1726688C>T	uc003mtq.2	-	9	1139	c.949G>A	c.(949-951)GTG>ATG	p.V317M		NM_001500	NP_001491	O60547	GMDS_HUMAN	GDP-mannose 4,6-dehydratase	317					'de novo' GDP-L-fucose biosynthetic process|GDP-mannose metabolic process|leukocyte cell-cell adhesion		coenzyme binding|GDP-mannose 4,6-dehydratase activity			central_nervous_system(1)	1	Ovarian(93;0.0733)	all_cancers(2;7.64e-19)|all_epithelial(2;3.05e-16)|Colorectal(2;0.00414)|all_hematologic(90;0.00997)|all_lung(73;0.0141)|Lung NSC(90;0.0802)		Epithelial(2;7.61e-06)|all cancers(2;0.000111)|STAD - Stomach adenocarcinoma(2;0.000231)|Colorectal(2;0.00445)|COAD - Colon adenocarcinoma(2;0.0125)|OV - Ovarian serous cystadenocarcinoma(45;0.0563)		TCCACAGTCACGTGAACTTTG	0.507													30	160					0	0	0.003271	0	0
TNXB	7148	broad.mit.edu	37	6	32049264	32049264	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr6:32049264G>A	uc003nzl.2	-	10	4125	c.3923C>T	c.(3922-3924)GCG>GTG	p.A1308V		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1395	Fibronectin type-III 6.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CTCATCCCCCGCAACAGGCAC	0.617													4	18					0	0	0.000602	0	0
GPR116	221395	broad.mit.edu	37	6	46826760	46826760	+	Silent	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr6:46826760C>T	uc003oyo.3	-	17	3169	c.2880G>A	c.(2878-2880)AGG>AGA	p.R960R	GPR116_uc011dwj.1_Silent_p.R515R|GPR116_uc011dwk.1_Silent_p.R389R|GPR116_uc003oyp.3_Silent_p.R818R|GPR116_uc003oyq.3_Silent_p.R960R|GPR116_uc010jzi.1_Silent_p.R632R	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	960	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			TGTTGGCAAGCCTGAAGTTCC	0.478													16	97					0	0	0.004007	0	0
RIMS1	22999	broad.mit.edu	37	6	72889453	72889453	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr6:72889453C>T	uc003pga.2	+	5	724	c.647C>T	c.(646-648)TCG>TTG	p.S216L	RIMS1_uc011dyb.1_5'Flank|RIMS1_uc003pgc.2_5'Flank|RIMS1_uc003pgb.3_5'Flank	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	216					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CAAGAGCGATCGCGGTCTCAG	0.597													5	150					0	0	0.001168	0	0
NT5E	4907	broad.mit.edu	37	6	86203685	86203685	+	Missense_Mutation	SNP	T	C	C			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr6:86203685T>C	uc003pko.3	+	9	2244	c.1688T>C	c.(1687-1689)CTT>CCT	p.L563P	NT5E_uc010kbr.2_Missense_Mutation_p.L513P	NM_002526	NP_002517	P21589	5NTD_HUMAN	5' nucleotidase, ecto precursor	563					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			ovary(3)|central_nervous_system(1)	4		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	TTAATATTTCTTTCACTTTGG	0.353													12	90					0	0	0.001855	0	0
HTR1E	3354	broad.mit.edu	37	6	87725427	87725427	+	Silent	SNP	C	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr6:87725427C>A	uc003pli.2	+	2	1078	c.375C>A	c.(373-375)ACC>ACA	p.T125T		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	125	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	GGGCCATCACCAATGCTATTG	0.562													17	127					1.67942e-08	2.56069e-08	0.006122	1	0
RNGTT	8732	broad.mit.edu	37	6	89563379	89563379	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr6:89563379C>T	uc003pmr.2	-	9	1221	c.1001G>A	c.(1000-1002)CGT>CAT	p.R334H	RNGTT_uc003pms.2_Missense_Mutation_p.R334H|RNGTT_uc011dzu.1_Missense_Mutation_p.R274H|RNGTT_uc003pmt.2_Missense_Mutation_p.R334H	NM_003800	NP_003791	O60942	MCE1_HUMAN	RNA guanylyltransferase and 5'-phosphatase	334	GTase.				interspecies interaction between organisms|mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	GTP binding|mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1		all_cancers(76;4.07e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;6.86e-05)		BRCA - Breast invasive adenocarcinoma(108;0.151)		TAAATGCATACGAAGATCTTT	0.289													12	90					0	0	0.013537	0	0
SMPD2	6610	broad.mit.edu	37	6	109764076	109764076	+	Missense_Mutation	SNP	C	T	T	rs139839878		TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr6:109764076C>T	uc003pti.2	+	7	1007	c.613C>T	c.(613-615)CGG>TGG	p.R205W	PPIL6_uc003ptg.3_5'Flank|PPIL6_uc010kdo.2_5'Flank|PPIL6_uc010kdp.2_5'Flank|PPIL6_uc003pth.1_5'Flank	NM_003080	NP_003071	O60906	NSMA_HUMAN	sphingomyelin phosphodiesterase 2, neutral	205					induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|sphingomyelin metabolic process	integral to plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity				0		all_cancers(87;1.1e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000144)|all_lung(197;0.0221)|Colorectal(196;0.0488)|Lung SC(18;0.0548)		Epithelial(106;0.0137)|all cancers(137;0.0188)|OV - Ovarian serous cystadenocarcinoma(136;0.0228)|BRCA - Breast invasive adenocarcinoma(108;0.0566)		TCTTGAAACTCGGGACTTCAA	0.542													10	137					0	0	0.006214	0	0
TMEM200A	114801	broad.mit.edu	37	6	130761742	130761742	+	Missense_Mutation	SNP	T	C	C			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr6:130761742T>C	uc003qca.2	+	3	1046	c.175T>C	c.(175-177)TCC>CCC	p.S59P	TMEM200A_uc010kfh.2_Missense_Mutation_p.S59P|TMEM200A_uc010kfi.2_Missense_Mutation_p.S59P|TMEM200A_uc003qcb.2_Missense_Mutation_p.S59P	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	59	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		CCGGCTTTATTCCCCATCTGG	0.478													60	86					0	0	0.014410	0	0
ZNF479	90827	broad.mit.edu	37	7	57187713	57187713	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr7:57187713C>T	uc010kzo.2	-	5	1680	c.1409G>A	c.(1408-1410)TGT>TAT	p.C470Y		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	470	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			GGCTTTGCCACATTCTTCACA	0.408													21	77					0	0	0.003954	0	0
FOXP2	93986	broad.mit.edu	37	7	114282537	114282537	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr7:114282537G>A	uc003vhb.2	+	7	1222	c.848G>A	c.(847-849)GGC>GAC	p.G283D	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.G308D|FOXP2_uc003vha.2_Missense_Mutation_p.G191D|FOXP2_uc011kmu.1_Missense_Mutation_p.G300D|FOXP2_uc011kmv.1_Missense_Mutation_p.G282D|FOXP2_uc010ljz.1_Missense_Mutation_p.G191D|FOXP2_uc003vgx.2_Missense_Mutation_p.G283D|FOXP2_uc003vhd.2_Missense_Mutation_p.G283D|FOXP2_uc003vhc.2_Missense_Mutation_p.G308D	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	283					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						GAAGACAATGGCATTAAACAT	0.428													33	56					0	0	0.013726	0	0
WNT2	7472	broad.mit.edu	37	7	116960776	116960776	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr7:116960776C>T	uc003viz.2	-	2	455	c.155G>A	c.(154-156)CGG>CAG	p.R52Q	WNT2_uc003vja.2_5'UTR	NM_003391	NP_003382	P09544	WNT2_HUMAN	wingless-type MMTV integration site family	52					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	7	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		ACACAGCTGCCGCTGGCTGCT	0.597													9	29					0	0	0.008291	0	0
AKR1B10	57016	broad.mit.edu	37	7	134212705	134212705	+	Silent	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr7:134212705C>T	uc003vrr.2	+	1	362	c.42C>T	c.(40-42)CCC>CCT	p.P14P		NM_020299	NP_064695	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10	14					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			skin(5)	5						CCAAGATGCCCATTGTGGGCC	0.502													17	78					0	0	0.006122	0	0
POLR3D	661	broad.mit.edu	37	8	22107627	22107627	+	Missense_Mutation	SNP	C	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr8:22107627C>A	uc003xbl.2	+	8	1044	c.961C>A	c.(961-963)CTG>ATG	p.L321M	POLR3D_uc003xbm.2_Missense_Mutation_p.L321M|POLR3D_uc011kze.1_RNA	NM_001722	NP_001713	P05423	RPC4_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	321					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity				0				Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		CCTGGCTGACCTGACAGAGGG	0.542													34	51					2.48696e-23	4.03149e-23	0.003271	1	0
DOCK5	80005	broad.mit.edu	37	8	25154057	25154057	+	Missense_Mutation	SNP	G	C	C			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr8:25154057G>C	uc003xeg.2	+	7	636	c.499G>C	c.(499-501)GAT>CAT	p.D167H	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_5'UTR|DOCK5_uc003xef.2_Missense_Mutation_p.D167H	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	167						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		GGTGGTGCGAGATGACAATGG	0.512													4	15					0	0	0.009096	0	0
ANK1	286	broad.mit.edu	37	8	41543690	41543690	+	Missense_Mutation	SNP	C	T	T	rs138642972	byFrequency	TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr8:41543690C>T	uc003xok.2	-	36	4454	c.4370G>A	c.(4369-4371)CGT>CAT	p.R1457H	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.R773H|ANK1_uc003xoi.2_Missense_Mutation_p.R1457H|ANK1_uc003xoj.2_Missense_Mutation_p.R1457H|ANK1_uc003xol.2_Missense_Mutation_p.R1457H|ANK1_uc003xom.2_Missense_Mutation_p.R1498H	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1457	55 kDa regulatory domain.|Death.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton	p.R1457H(1)		ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TTGGCCTTCACGGATGACCCA	0.522													25	72					0	0	0.006320	0	0
CLVS1	157807	broad.mit.edu	37	8	62371030	62371030	+	Silent	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr8:62371030C>T	uc003xuh.2	+	5	1230	c.906C>T	c.(904-906)TCC>TCT	p.S302S	CLVS1_uc003xui.2_RNA|CLVS1_uc010lyp.2_Intron	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	302					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						CTCACACATCCTATAATGCAA	0.502													20	51					0	0	0.002780	0	0
COL5A1	1289	broad.mit.edu	37	9	137591840	137591840	+	Silent	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr9:137591840C>T	uc004cfe.2	+	3	745	c.363C>T	c.(361-363)AAC>AAT	p.N121N		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	121	TSP N-terminal.|Laminin G-like.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCATCTACAACGAGCAGGGTA	0.587													27	113					0	0	0.007291	0	0
GYG2	8908	broad.mit.edu	37	X	2799186	2799186	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chrX:2799186C>T	uc004cqs.1	+	12	1720	c.1438C>T	c.(1438-1440)CGT>TGT	p.R480C	GYG2_uc004cqt.1_Missense_Mutation_p.R449C|GYG2_uc004cqu.1_Missense_Mutation_p.R448C|GYG2_uc004cqv.1_Missense_Mutation_p.R223C|GYG2_uc004cqw.1_Missense_Mutation_p.R440C|GYG2_uc004cqx.1_Missense_Mutation_p.R378C|GYG2_uc010ndc.1_Missense_Mutation_p.R258C	NM_003918	NP_003909	O15488	GLYG2_HUMAN	glycogenin 2 isoform b	480					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|soluble fraction	glycogenin glucosyltransferase activity			ovary(1)|kidney(1)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGAGGAAGGCCGTATCGACTA	0.572													7	29					0	0	0.003080	0	0
PRPS2	5634	broad.mit.edu	37	X	12838861	12838861	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chrX:12838861C>T	uc004cvb.2	+	6	927	c.803C>T	c.(802-804)GCT>GTT	p.A268V	PRPS2_uc004cva.2_Missense_Mutation_p.A271V|PRPS2_uc010nec.2_Missense_Mutation_p.A146V	NM_002765	NP_002756	P11908	PRPS2_HUMAN	phosphoribosyl pyrophosphate synthetase 2	268					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity				0						GCCTTTGAGGCTGTTGTCGTC	0.483													19	70					0	0	0.010504	0	0
RS1	6247	broad.mit.edu	37	X	18660177	18660177	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chrX:18660177C>T	uc004cyo.2	-	6	657	c.622G>A	c.(622-624)GTC>ATC	p.V208I	CDKL5_uc004cym.2_Intron|CDKL5_uc004cyn.2_Intron	NM_000330	NP_000321	O15537	XLRS1_HUMAN	X-linked juvenile retinoschisis protein	208	F5/8 type C.				cell adhesion|multicellular organismal development|response to stimulus|visual perception	extracellular space				ovary(2)	2	Hepatocellular(33;0.183)					GCAATGCGGACGTGCCAGCCC	0.657													26	63					0	0	0.004656	0	0
POLA1	5422	broad.mit.edu	37	X	24830876	24830876	+	Silent	SNP	G	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chrX:24830876G>A	uc004dbl.2	+	29	3197	c.3174G>A	c.(3172-3174)CTG>CTA	p.L1058L		NM_016937	NP_058633	P09884	DPOLA_HUMAN	DNA-directed DNA polymerase alpha 1	1058					cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			ovary(2)|skin(1)	3					Clofarabine(DB00631)|Fludarabine(DB01073)	ACGCTGCTCTGGTTGTTGAGC	0.393													20	50					0	0	0.014323	0	0
FAM47B	170062	broad.mit.edu	37	X	34962025	34962025	+	Silent	SNP	C	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chrX:34962025C>T	uc004ddi.1	+	1	1095	c.1077C>T	c.(1075-1077)GAC>GAT	p.D359D		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	359										ovary(3)|breast(1)	4						AGCTGGAAGACGCACGGGCTC	0.537													20	53					0	0	0.008871	0	0
CFP	5199	broad.mit.edu	37	X	47487019	47487019	+	Missense_Mutation	SNP	C	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chrX:47487019C>A	uc004dig.3	-	4	551	c.425G>T	c.(424-426)TGG>TTG	p.W142L	CFP_uc004dih.2_Missense_Mutation_p.W142L|CFP_uc004dii.1_Missense_Mutation_p.W78L|CFP_uc010nhu.2_Missense_Mutation_p.W142L	NM_001145252	NP_001138724	P27918	PROP_HUMAN	complement factor properdin precursor	142	TSP type-1 2.				complement activation, alternative pathway|defense response to bacterium	extracellular space				breast(2)|lung(1)	3						CCAGGGCCCCCAGCCAGACCA	0.632													7	16					0.00198382	0.00285521	0.001984	1	0
FAM120C	54954	broad.mit.edu	37	X	54209051	54209051	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chrX:54209051G>A	uc004dsz.3	-	1	664	c.581C>T	c.(580-582)GCG>GTG	p.A194V	FAM120C_uc011moh.1_Missense_Mutation_p.A194V|FAM120C_uc004dta.2_Missense_Mutation_p.A194V	NM_017848	NP_060318	Q9NX05	F120C_HUMAN	hypothetical protein LOC54954	194										ovary(1)|central_nervous_system(1)	2						GATCAGTTGCGCTGTCTGCCG	0.721													7	15					0	0	0.001984	0	0
USP51	158880	broad.mit.edu	37	X	55514135	55514135	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chrX:55514135G>A	uc004dun.1	-	2	1317	c.1238C>T	c.(1237-1239)TCG>TTG	p.S413L	USP51_uc011moo.1_Missense_Mutation_p.S117L	NM_201286	NP_958443	Q70EK9	UBP51_HUMAN	ubiquitin specific protease 51	413					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						ATGAAAAAGCGAAGACATTTC	0.438													14	45					0	0	0.002450	0	0
KIAA2022	340533	broad.mit.edu	37	X	73963361	73963361	+	Missense_Mutation	SNP	G	T	T			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chrX:73963361G>T	uc004eby.2	-	3	1648	c.1031C>A	c.(1030-1032)ACC>AAC	p.T344N		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	344					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						CTTGGGGCAGGTAGTAAAGAC	0.463													17	69					1.5739e-10	2.44828e-10	0.004007	1	0
AMMECR1	9949	broad.mit.edu	37	X	109459855	109459855	+	Missense_Mutation	SNP	A	G	G			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chrX:109459855A>G	uc004eoo.2	-	3	671	c.590T>C	c.(589-591)CTT>CCT	p.L197P	AMMECR1_uc004eop.2_Missense_Mutation_p.L160P|AMMECR1_uc004eoq.2_Missense_Mutation_p.L74P	NM_015365	NP_056180	Q9Y4X0	AMER1_HUMAN	AMMECR1 protein isoform 1	197	AMMECR1.										0						GCTATCTTTAAGGGCACTGTT	0.378													21	95					0	0	0.012319	0	0
GPC3	2719	broad.mit.edu	37	X	132887606	132887606	+	Missense_Mutation	SNP	C	A	A			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chrX:132887606C>A	uc004exe.1	-	3	1125	c.935G>T	c.(934-936)AGA>ATA	p.R312I	GPC3_uc004exd.1_Missense_Mutation_p.R184I|GPC3_uc010nrn.1_Missense_Mutation_p.R312I|GPC3_uc011mvh.1_Missense_Mutation_p.R296I|GPC3_uc010nro.1_Missense_Mutation_p.R258I|GPC3_uc010nrp.1_Missense_Mutation_p.R184I	NM_004484	NP_004475	P51654	GPC3_HUMAN	glypican 3 isoform 2 precursor	312						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			lung(2)|prostate(1)|breast(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					GTCATAGATTCTGTACATGCC	0.443			T|D|Mis|N|F|S			Wilms tumour			Simpson-Golabi-Behmel_syndrome				6	144					8.12818e-05	0.000121528	0.001984	1	0
FAM21B	55747	broad.mit.edu	37	10	47909193	47909194	+	Frame_Shift_Del	DEL	CC	-	-			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr10:47909193_47909194delCC	uc009xni.2	+	10	763_764	c.763_764delCC	c.(763-765)CCCfs	p.P255fs	FAM21B_uc001jep.3_Frame_Shift_Del_p.P150fs	NM_018232	NP_060702	Q5SNT6	FA21B_HUMAN	hypothetical protein LOC55747	255					retrograde transport, endosome to Golgi	early endosome membrane|WASH complex				ovary(1)	1						CTTATTCACACCCCCCAAGCTG	0.515													2	4	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7577105	7577105	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr17:7577105delG	uc002gim.2	-	8	1027	c.833delC	c.(832-834)CCTfs	p.P278fs	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Frame_Shift_Del_p.P278fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.P146fs|TP53_uc010cng.1_Frame_Shift_Del_p.P146fs|TP53_uc002gii.1_Frame_Shift_Del_p.P146fs|TP53_uc010cnh.1_Frame_Shift_Del_p.P278fs|TP53_uc010cni.1_Frame_Shift_Del_p.P278fs|TP53_uc002gij.2_Frame_Shift_Del_p.P278fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	278	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P278L(52)|p.P278S(48)|p.P278R(26)|p.P278T(21)|p.P278A(17)|p.P278H(11)|p.0?(7)|p.P278fs*67(5)|p.P278F(3)|p.P278fs*28(2)|p.?(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.V274_P278del(1)|p.P278P(1)|p.C277_P278insXXXXXXX(1)|p.F270_D281del12(1)|p.P278_G279insXXXXX(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTCTCTCCCAGGACAGGCACA	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			38	13	---	---	---	---					
EMILIN2	84034	broad.mit.edu	37	18	2891806	2891806	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr18:2891806delC	uc002kln.2	+	4	1840	c.1681delC	c.(1681-1683)CCTfs	p.P561fs		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	561					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		CCAGGGAAAGCCTCATGGGAT	0.502													23	64	---	---	---	---					
CYTH4	27128	broad.mit.edu	37	22	37705324	37705326	+	In_Frame_Del	DEL	CTT	-	-			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr22:37705324_37705326delCTT	uc003arf.2	+	9	884_886	c.768_770delCTT	c.(766-771)ACCTTC>ACC	p.F258del	CYTH4_uc003are.2_3'UTR|CYTH4_uc011amw.1_In_Frame_Del_p.F201del|CYTH4_uc010gxe.2_Intron	NM_013385	NP_037517	Q9UIA0	CYH4_HUMAN	cytohesin 4	258					regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						TCACTCACACCTTCTTCAATCCA	0.542													45	81	---	---	---	---					
SDHAP2	727956	broad.mit.edu	37	3	195400814	195400815	+	Frame_Shift_Ins	INS	-	TT	TT			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr3:195400814_195400815insTT	uc003fuw.2	+	9	1304_1305	c.110_111insTT	c.(109-111)TCTfs	p.S37fs	SDHAP2_uc011btb.1_Frame_Shift_Ins_p.V184fs|SDHAP2_uc011btc.1_RNA|SDHAP2_uc003fuv.2_RNA					SubName: Full=cDNA FLJ16373 fis, clone THYMU3000269, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						ACCTGGTTGTCTGGTCAGGCAT	0.574													7	29	---	---	---	---					
PDGFRA	5156	broad.mit.edu	37	4	55151636	55151636	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr4:55151636delT	uc003han.3	+	17	2753	c.2422delT	c.(2422-2424)TTTfs	p.F808fs	PDGFRA_uc003haa.2_Frame_Shift_Del_p.F568fs	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	808	Protein kinase.|Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity	p.F808L(1)		soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	AGGAATGGAGTTTTTGGCTTC	0.418			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			9	2168	---	---	---	---					
CLOCK	9575	broad.mit.edu	37	4	56304530	56304532	+	In_Frame_Del	DEL	CTG	-	-			TCGA-CS-6665-01A-11D-1893-08	TCGA-CS-6665-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	682d5b5e-3569-403c-b31c-887bd0aa26a5	c4574016-bc61-4fb5-92c6-efccec8cdc5d	g.chr4:56304530_56304532delCTG	uc003haz.1	-	23	3204_3206	c.2278_2280delCAG	c.(2278-2280)CAGdel	p.Q760del	CLOCK_uc003hba.1_In_Frame_Del_p.Q760del|CLOCK_uc010igu.1_RNA	NM_004898	NP_004889	O15516	CLOCK_HUMAN	clock	760	Gln-rich.				circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			cctgggagctctgctgctgctgc	0.315													8	603	---	---	---	---					
