Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
C1orf174	339448	broad.mit.edu	37	1	3809463	3809463	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr1:3809463G>A	uc001alf.2	-	2	220	c.113C>T	c.(112-114)GCC>GTC	p.A38V	C1orf174_uc009vls.2_RNA	NM_207356	NP_997239	Q8IYL3	CA174_HUMAN	hypothetical protein LOC339448	38											0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_cancers(23;5.09e-25)|all_epithelial(116;9.35e-17)|all_lung(118;1.09e-06)|Lung NSC(185;0.000139)|all_neural(13;0.00287)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0219)|all_hematologic(16;0.027)|Colorectal(325;0.0276)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;1.55e-39)|OV - Ovarian serous cystadenocarcinoma(86;5.99e-23)|GBM - Glioblastoma multiforme(42;2.22e-17)|Colorectal(212;1.08e-05)|COAD - Colon adenocarcinoma(227;5.49e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000365)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.19)		TGCTGTCTTGGCAGACGTGGA	0.542000													3	28					0	0	0.115264	0	0
DHDDS	79947	broad.mit.edu	37	1	26772898	26772898	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr1:26772898G>A	uc001bml.2	+	5	536	c.415G>A	c.(415-417)GTA>ATA	p.V139I	DHDDS_uc001bmk.2_Missense_Mutation_p.V139I|DHDDS_uc001bmm.2_Missense_Mutation_p.V46I|DHDDS_uc001bmn.2_Intron|DHDDS_uc010ofd.1_Missense_Mutation_p.V139I	NM_205861	NP_995583	Q86SQ9	DHDDS_HUMAN	dehydrodolichyl diphosphate synthase isoform b	139							protein binding|transferase activity, transferring alkyl or aryl (other than methyl) groups			breast(3)	3		all_cancers(24;2.04e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.0161)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.166)|LUSC - Lung squamous cell carcinoma(448;0.239)		TGCACAAGCTGTACAGGCCAC	0.517000													41	79					0	0	0.864702	0	0
FMN2	56776	broad.mit.edu	37	1	240371067	240371067	+	Silent	SNP	C	A	A			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr1:240371067C>A	uc010pyd.1	+	5	3180	c.2955C>A	c.(2953-2955)GGC>GGA	p.G985G	FMN2_uc010pye.1_Silent_p.G989G	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	985	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCGGAGCGGGCATACCCCCTC	0.711000													3	13					6.4e-05	6.7122e-05	0.115264	1	0
LOC653544	653544	broad.mit.edu	37	10	135491100	135491100	+	Silent	SNP	G	T	T			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr10:135491100G>T	uc010qvi.1	+	1	822	c.711G>T	c.(709-711)TCG>TCT	p.S237S		NM_001127389	NP_001120861	F5GZ66	F5GZ66_HUMAN	double homeobox, 4-like	237						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CTGCTCCCTCGTGGGTCGCCT	0.761000													4	13					5.68852e-11	6.43701e-11	0.307466	1	0
SLCO1B1	10599	broad.mit.edu	37	12	21329781	21329781	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr12:21329781T>C	uc001req.3	+	5	535	c.431T>C	c.(430-432)ATT>ACT	p.I144T		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	144	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	ACTTGTTTAATTAATCAAATT	0.274000													39	41					0	0	0.812448	0	0
KNTC1	9735	broad.mit.edu	37	12	123014673	123014673	+	Silent	SNP	T	G	G			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr12:123014673T>G	uc001ucv.2	+	2	226	c.63T>G	c.(61-63)GGT>GGG	p.G21G	KNTC1_uc010taf.1_Silent_p.G21G	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	21					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TGAGTGTCGGTTCAAGAAAAG	0.403000													9	36					0	0	0.520397	0	0
DDX55	57696	broad.mit.edu	37	12	124101060	124101060	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr12:124101060G>T	uc001ufi.2	+	10	983	c.959G>T	c.(958-960)GGG>GTG	p.G320V	DDX55_uc001ufh.2_Missense_Mutation_p.G173V|DDX55_uc001ufj.1_Missense_Mutation_p.G173V|DDX55_uc001ufk.2_Missense_Mutation_p.G173V|DDX55_uc001ufl.2_5'Flank	NM_020936	NP_065987	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	320	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		TTTCCTAGTGGGATTTTAGTG	0.473000													4	67					5.9392e-07	6.54835e-07	0.217242	1	0
ZFYVE26	23503	broad.mit.edu	37	14	68251787	68251787	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr14:68251787C>T	uc001xka.2	-	19	3651	c.3512G>A	c.(3511-3513)AGC>AAC	p.S1171N	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.S1171N	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1171					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		AGGCTCAGAGCTCAAACTTTG	0.502000													69	101					0	0	0.870114	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102508452	102508452	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr14:102508452A>G	uc001yks.2	+	66	12369	c.12205A>G	c.(12205-12207)ATT>GTT	p.I4069V		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	4069	AAA 6 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						GATCACTTCAATTGCAATCGG	0.537000													11	18					0	0	0.411799	0	0
XPO6	23214	broad.mit.edu	37	16	28137080	28137080	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr16:28137080G>A	uc002dpa.1	-	13	2197	c.1696C>T	c.(1696-1698)CGC>TGC	p.R566C	XPO6_uc002dpb.1_Missense_Mutation_p.R552C|XPO6_uc010vcp.1_Missense_Mutation_p.R566C	NM_015171	NP_055986	Q96QU8	XPO6_HUMAN	exportin 6	566					protein export from nucleus		protein binding|protein transporter activity			ovary(1)|skin(1)	2						TCGGCCAGGCGGCCCACGGCC	0.582000													29	111					0	0	0.729181	0	0
ITGAD	3681	broad.mit.edu	37	16	31419095	31419095	+	Silent	SNP	C	T	T			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr16:31419095C>T	uc002ebv.1	+	9	916	c.867C>T	c.(865-867)CAC>CAT	p.H289H	ITGAD_uc010vfl.1_Missense_Mutation_p.R322C|ITGAD_uc010cap.1_Silent_p.H289H|ITGAD_uc002ebw.1_Missense_Mutation_p.R133C	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	289	Extracellular (Potential).|VWFA.				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						AGGTGGGACACGCTTTCCAGG	0.617000													17	21					0	0	0.557998	0	0
TP53	7157	broad.mit.edu	37	17	7574018	7574018	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr17:7574018G>A	uc002gim.2	-	10	1203	c.1009C>T	c.(1009-1011)CGC>TGC	p.R337C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Missense_Mutation_p.R205C|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Missense_Mutation_p.R337C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	337	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.		R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R337C(12)|p.0?(7)|p.R337L(5)|p.R337H(2)|p.?(1)|p.I332fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATCTCGAAGCGCTCACGCCCA	0.448000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	8					0	0	0.557998	0	0
MYH4	4622	broad.mit.edu	37	17	10350460	10350460	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr17:10350460C>T	uc002gmn.2	-	35	5150	c.5039G>A	c.(5038-5040)CGC>CAC	p.R1680H	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1680	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GTTAGCTCTGCGCTCAACCAT	0.502000													4	66					0	0	0.150653	0	0
MAP2K3	5606	broad.mit.edu	37	17	21217496	21217496	+	Missense_Mutation	SNP	C	T	T	rs35755743		TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr17:21217496C>T	uc002gys.2	+	12	1263	c.998C>T	c.(997-999)ACG>ATG	p.T333M	MAP2K3_uc002gyt.2_Missense_Mutation_p.T304M|MAP2K3_uc002gyu.2_Missense_Mutation_p.T304M	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	333					activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		ACCAAGAAGACGGACATTGCT	0.617000													65	300					0	0	0.870114	0	0
SUZ12P	440423	broad.mit.edu	37	17	29061941	29061941	+	RNA	SNP	T	C	C	rs112064181	by1000genomes	TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr17:29061941T>C	uc002hfn.1	+	2		c.1143T>C			SUZ12P_uc002hfo.2_Intron|SUZ12P_uc002hfp.2_RNA|SUZ12P_uc002hfq.2_RNA					Homo sapiens cDNA clone IMAGE:5299523, containing frame-shift errors.												0						TAGATTTCTTTGAACTCGGAA	0.303000													6	60					0	0	0.217242	0	0
TMC6	11322	broad.mit.edu	37	17	76116777	76116777	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr17:76116777C>T	uc002juj.1	-	12	1798	c.1672G>A	c.(1672-1674)GTC>ATC	p.V558I	TMC6_uc002jui.1_Intron|TMC6_uc010dhf.1_Missense_Mutation_p.V391I|TMC6_uc002juk.2_Missense_Mutation_p.V558I|TMC6_uc010dhg.1_Intron|TMC6_uc002jul.1_Missense_Mutation_p.V558I|TMC6_uc002jum.3_Missense_Mutation_p.V349I|TMC6_uc002jun.3_Missense_Mutation_p.V558I|TMC6_uc002juo.2_3'UTR	NM_007267	NP_009198	Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	558	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			AACATGAGGACGAAGTCCATC	0.637000									Epidermodysplasia_Verruciformis_Familial_Clustering_of				29	106					0	0	0.717897	0	0
CEACAM5	1048	broad.mit.edu	37	19	42224879	42224879	+	Silent	SNP	G	A	A			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr19:42224879G>A	uc002ork.2	+	8	1930	c.1809G>A	c.(1807-1809)TCG>TCA	p.S603S	CEACAM5_uc002orj.1_Silent_p.S602S|CEACAM5_uc002orl.2_Silent_p.S603S	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	603	Ig-like 7.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		CCCCAGACTCGTCTTACCTTT	0.547000													45	63					0	0	0.847076	0	0
IDH1	3417	broad.mit.edu	37	2	209113113	209113113	+	Missense_Mutation	SNP	G	T	T	rs121913499		TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr2:209113113G>T	uc002vcs.2	-	4	640	c.394C>A	c.(394-396)CGT>AGT	p.R132S	IDH1_uc002vct.2_Missense_Mutation_p.R132S|IDH1_uc002vcu.2_Missense_Mutation_p.R132S	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		TAAGCATGACGACCTATGATG	0.398000			Mis		gliobastoma 								26	48					6.32553e-13	7.35129e-13	0.681144	1	0
CELSR1	9620	broad.mit.edu	37	22	46929726	46929726	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr22:46929726G>C	uc003bhw.1	-	1	3342	c.3342C>G	c.(3340-3342)AAC>AAG	p.N1114K		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1114	Extracellular (Potential).|Cadherin 9.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TGTTGGACTTGTTGGTGACAT	0.592000													78	91					0	0	0.870114	0	0
SDHAP1	255812	broad.mit.edu	37	3	195701304	195701304	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr3:195701304C>T	uc011btq.1	-	8	1189	c.560G>A	c.(559-561)GGC>GAC	p.G187D	SDHAP1_uc003fvx.3_RNA|SDHAP1_uc011btp.1_RNA					SubName: Full=cDNA FLJ56858, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						AGGGCACATGCCTGACCAGAC	0.572000													5	39					0	0	0.248553	0	0
SLIT2	9353	broad.mit.edu	37	4	20490510	20490510	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr4:20490510G>A	uc003gpr.1	+	8	884	c.680G>A	c.(679-681)AGG>AAG	p.R227K	SLIT2_uc003gps.1_Missense_Mutation_p.R227K	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	227	LRRCT 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						CTTCGCCAAAGGCCTCGGGTT	0.498000													31	154					0	0	0.796494	0	0
PRPH2	5961	broad.mit.edu	37	6	42690067	42690067	+	Silent	SNP	C	T	T			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr6:42690067C>T	uc003osk.2	-	1	292	c.6G>A	c.(4-6)GCG>GCA	p.A2A		NM_000322	NP_000313	P23942	PRPH2_HUMAN	peripherin 2	2	Cytoplasmic (Potential).				cell adhesion|visual perception	integral to membrane				ovary(4)|central_nervous_system(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			CTTTCAGTAGCGCCATGCTTG	0.552000													3	44					0	0	0.115264	0	0
LAMA2	3908	broad.mit.edu	37	6	129419503	129419503	+	Silent	SNP	T	C	C			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr6:129419503T>C	uc003qbn.2	+	4	687	c.582T>C	c.(580-582)GAT>GAC	p.D194D	LAMA2_uc003qbo.2_Silent_p.D194D	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	194	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		ATGCCAAAGATGATGAGGTCA	0.443000													9	60					0	0	0.307466	0	0
TNFAIP3	7128	broad.mit.edu	37	6	138199814	138199814	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr6:138199814G>A	uc003qhr.2	+	7	1298	c.1232G>A	c.(1231-1233)CGG>CAG	p.R411Q	TNFAIP3_uc003qhs.2_Missense_Mutation_p.R411Q	NM_006290	NP_006281	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	411	Interaction with NAF1 (By similarity).|A20-type 1.				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(22)		haematopoietic_and_lymphoid_tissue(133)|lung(3)|ovary(1)	137	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		TCAGAGAGGCGGCAAAAGAAT	0.557000			D|N|F		marginal zone B-cell lymphomas|Hodgkin's lymphoma|primary mediastinal B cell lymphoma								6	76					0	0	0.248553	0	0
SMOC2	64094	broad.mit.edu	37	6	168947817	168947817	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr6:168947817C>A	uc003qws.1	+	6	550	c.530C>A	c.(529-531)GCG>GAG	p.A177E	SMOC2_uc003qwr.1_Missense_Mutation_p.A188E	NM_022138	NP_071421	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	177					signal transduction	basement membrane	calcium ion binding			ovary(1)	1		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)		GCAGCTCCAGCGTTGGAGACT	0.522000													4	148					0.00909568	0.00931224	0.150653	1	0
TBP	6908	broad.mit.edu	37	6	170871052	170871052	+	Silent	SNP	G	A	A	rs112083427		TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr6:170871052G>A	uc003qxt.2	+	3	460	c.228G>A	c.(226-228)CAG>CAA	p.Q76Q	TBP_uc003qxu.2_Silent_p.Q76Q|TBP_uc011ehf.1_Silent_p.Q56Q|TBP_uc011ehg.1_Silent_p.Q76Q	NM_003194	NP_003185	P20226	TBP_HUMAN	TATA box binding protein	76	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcaacagcagcagcagcagc	0.159000													3	9					0	0	0.115264	0	0
TBP	6908	broad.mit.edu	37	6	170871070	170871070	+	Silent	SNP	G	A	A	rs142508797	byFrequency	TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr6:170871070G>A	uc003qxt.2	+	3	478	c.246G>A	c.(244-246)CAG>CAA	p.Q82Q	TBP_uc003qxu.2_Silent_p.Q82Q|TBP_uc011ehf.1_Silent_p.Q62Q|TBP_uc011ehg.1_Silent_p.Q82Q	NM_003194	NP_003185	P20226	TBP_HUMAN	TATA box binding protein	82	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcagcagcagcagcagc	0.174000													3	18					0	0	0.115264	0	0
PTCD1	26024	broad.mit.edu	37	7	99026819	99026819	+	Silent	SNP	G	A	A			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr7:99026819G>A	uc003uqh.2	-	5	953	c.822C>T	c.(820-822)ATC>ATT	p.I274I	PTCD1_uc011kiw.1_Silent_p.I323I	NM_015545	NP_056360	O75127	PTCD1_HUMAN	pentatricopeptide repeat domain 1	274	PPR 4.									ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			GCCCTTTGTGGATGATTTCCT	0.418000													9	89					0	0	0.387290	0	0
TM7SF4	81501	broad.mit.edu	37	8	105361004	105361004	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr8:105361004C>G	uc003ylx.1	+	2	273	c.224C>G	c.(223-225)TCC>TGC	p.S75C		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	75	Helical; (Potential).				osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CTGTGTTGCTCCAAGCATGCA	0.522000													3	73					0	0	0.150653	0	0
ENPP2	5168	broad.mit.edu	37	8	120596283	120596283	+	Silent	SNP	A	G	G			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr8:120596283A>G	uc003yot.1	-	16	1460	c.1374T>C	c.(1372-1374)CCT>CCC	p.P458P	ENPP2_uc011lic.1_5'UTR|ENPP2_uc003yor.1_Silent_p.P97P|ENPP2_uc003yos.1_Silent_p.P510P|ENPP2_uc010mdd.1_Silent_p.P458P	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	458					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			AAACATCCAAAGGTTTCCTAA	0.348000													66	61					0	0	0.870114	0	0
KCNT1	57582	broad.mit.edu	37	9	138657002	138657002	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr9:138657002G>T	uc011mdq.1	+	12	1235	c.1161G>T	c.(1159-1161)ATG>ATT	p.M387I	KCNT1_uc011mdr.1_Missense_Mutation_p.M214I|KCNT1_uc010nbf.2_Missense_Mutation_p.M342I|KCNT1_uc004cgo.1_Missense_Mutation_p.M136I	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	387						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		ACCTTCTCATGGACTTCCTGA	0.642000													11	87					3.86212e-05	4.15178e-05	0.361761	1	0
TUBB2C	10383	broad.mit.edu	37	9	140136180	140136180	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr9:140136180A>G	uc004cmh.1	+	2	167	c.65A>G	c.(64-66)GAG>GGG	p.E22G	TUBB2C_uc004cmg.1_5'UTR	NM_006088	NP_006079	P68371	TBB2C_HUMAN	tubulin, beta, 2	22					'de novo' posttranslational protein folding|cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding|structural molecule activity|unfolded protein binding			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		TAGTTTTGGGAGGTGATCAGC	0.348000													8	17					0	0	0.278610	0	0
CXorf23	256643	broad.mit.edu	37	X	19983583	19983583	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chrX:19983583G>T	uc004czp.2	-	3	853	c.853C>A	c.(853-855)CGT>AGT	p.R285S	CXorf23_uc010nfn.2_RNA|CXorf23_uc011mjg.1_5'UTR|CXorf23_uc004czo.2_Missense_Mutation_p.R235S	NM_198279	NP_938020	A2AJT9	CX023_HUMAN	hypothetical protein LOC256643	285						mitochondrion				lung(1)|skin(1)	2						AGCTTAGGACGTTTGTGACGA	0.458000													36	33					1.47244e-24	1.75875e-24	0.819951	1	0
HDAC6	10013	broad.mit.edu	37	X	48682452	48682452	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chrX:48682452A>G	uc011mmi.1	+	27	3519	c.3424A>G	c.(3424-3426)AAT>GAT	p.N1142D	HDAC6_uc004dks.1_Missense_Mutation_p.N1142D|HDAC6_uc010nig.1_Missense_Mutation_p.N990D|HDAC6_uc004dkt.1_Missense_Mutation_p.N1142D|HDAC6_uc011mmk.1_Missense_Mutation_p.N1123D|HDAC6_uc004dkv.1_Missense_Mutation_p.N790D|HDAC6_uc004dkw.1_Missense_Mutation_p.N790D|HDAC6_uc004dkx.1_Missense_Mutation_p.N505D	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	1142	UBP-type.				aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	AATCCAAGAGAATTGGGTGTG	0.592000													5	48					0	0	0.184627	0	0
LPAR4	2846	broad.mit.edu	37	X	78010568	78010568	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chrX:78010568A>G	uc010nme.2	+	2	607	c.202A>G	c.(202-204)ATG>GTG	p.M68V		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	68	Cytoplasmic (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						CTGTTTCCGCATGAAAATGAG	0.358000													49	251					0	0	0.870114	0	0
GLUD2	2747	broad.mit.edu	37	X	120182836	120182836	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chrX:120182836G>A	uc004eto.2	+	1	1375	c.1298G>A	c.(1297-1299)GGA>GAA	p.G433E		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	433					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	TTGAATGCTGGAGGAGTGACA	0.418000													18	191					0	0	0.608945	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995655	140995655	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chrX:140995655C>T	uc004fbt.2	+	4	2751	c.2465C>T	c.(2464-2466)TCA>TTA	p.S822L	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	822							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCCACTTCATCGAGTCTT	0.562000										HNSCC(15;0.026)			10	209					0	0	0.361761	0	0
ESCO2	157570	broad.mit.edu	37	8	27634263	27634266	+	Frame_Shift_Del	DEL	TAAG	-	-			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chr8:27634263_27634266delTAAG	uc003xgg.2	+	3	521_524	c.438_441delTAAG	c.(436-441)GCTAAGfs	p.A146fs	ESCO2_uc010luy.1_RNA|ESCO2_uc003xgh.2_Frame_Shift_Del_p.A146fs	NM_001017420	NP_001017420	Q56NI9	ESCO2_HUMAN	establishment of cohesion 1 homolog 2	146_147					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			central_nervous_system(1)	1		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|KIRC - Kidney renal clear cell carcinoma(542;0.0955)|Kidney(114;0.115)|Colorectal(74;0.132)		GTTTAACTGCTAAGTATCAACCAA	0.353									SC_Phocomelia_syndrome				23	39	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76939673	76939674	+	Frame_Shift_Ins	INS	-	T	T			TCGA-DU-6401-01A-11D-1705-08	TCGA-DU-6401-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a81f733-b3a3-4578-b925-a663612bc92c	194434ed-46e0-4ce9-9f8f-38593d2d09c7	g.chrX:76939673_76939674insT	uc004ecp.3	-	9	1306_1307	c.1074_1075insA	c.(1072-1077)AAACTGfs	p.K358fs	ATRX_uc004ecq.3_Frame_Shift_Ins_p.K320fs|ATRX_uc004eco.3_Frame_Shift_Ins_p.K143fs|ATRX_uc004ecr.2_Frame_Shift_Ins_p.K319fs|ATRX_uc010nlx.1_Frame_Shift_Ins_p.K358fs|ATRX_uc010nly.1_Frame_Shift_Ins_p.K303fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	358_359					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	GTCTCAATCAGTTTTTTTGCCT	0.366			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						52	97	---	---	---	---					
