Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
VPS13D	55187	broad.mit.edu	37	1	12378242	12378242	+	Missense_Mutation	SNP	A	G	G			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr1:12378242A>G	uc001atv.2	+	31	7403	c.7262A>G	c.(7261-7263)AAG>AGG	p.K2421R	VPS13D_uc001atw.2_Missense_Mutation_p.K2421R|VPS13D_uc001atx.2_Missense_Mutation_p.K1609R|VPS13D_uc001aty.1_Missense_Mutation_p.K159R	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	2421					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AGTGATATTAAGAAACAAAAT	0.428000													4	173					0	0	1	0	0
CROCCL1	84809	broad.mit.edu	37	1	16946434	16946434	+	RNA	SNP	C	T	T	rs367060		TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr1:16946434C>T	uc010ocf.1	-	3		c.464G>A			CROCCL1_uc009vov.1_RNA|CROCCL1_uc001aze.2_RNA|CROCCL1_uc001azf.2_RNA					Homo sapiens mRNA for FLJ00313 protein.												0						CTCAGCCTTCCGCCGGGCCAG	0.672000													5	21					0	0	1	0	0
KIF17	57576	broad.mit.edu	37	1	20992723	20992723	+	Silent	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr1:20992723G>A	uc001bdr.3	-	14	3013	c.2895C>T	c.(2893-2895)GAC>GAT	p.D965D	KIF17_uc001bdp.3_Silent_p.D242D|KIF17_uc001bdq.3_Silent_p.D243D|KIF17_uc009vpx.2_Silent_p.D335D|KIF17_uc001bds.3_Silent_p.D964D	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	965					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		TCTTCCTGGCGTCTGTGCTGA	0.517000													4	104					0	0	1	0	0
LRIG2	9860	broad.mit.edu	37	1	113637236	113637236	+	Missense_Mutation	SNP	A	G	G			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr1:113637236A>G	uc001edf.1	+	6	860	c.662A>G	c.(661-663)GAA>GGA	p.E221G	LRIG2_uc009wgn.1_Missense_Mutation_p.E118G	NM_014813	NP_055628	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like	221	LRR 7.|Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		TGTTAAAGGGAACTTAAAAGA	0.303000													21	71					0	0	1	0	0
PTGFRN	5738	broad.mit.edu	37	1	117504195	117504195	+	Missense_Mutation	SNP	G	C	C			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr1:117504195G>C	uc001egv.1	+	5	1681	c.1544G>C	c.(1543-1545)TGT>TCT	p.C515S		NM_020440	NP_065173	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor negative regulator	515	Extracellular (Potential).|Ig-like C2-type 4.					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			liver(1)	1	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		AATTATTACTGTGTTGTGTCT	0.453000													32	62					0	0	1	0	0
WARS2	10352	broad.mit.edu	37	1	119683216	119683216	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr1:119683216C>T	uc001ehn.2	-	1	80	c.52G>A	c.(52-54)GCA>ACA	p.A18T	WARS2_uc010oxf.1_5'Flank|WARS2_uc001ehm.2_Missense_Mutation_p.A18T|WARS2_uc010oxg.1_Missense_Mutation_p.A18T|WARS2_uc010oxh.1_Missense_Mutation_p.A18T|WARS2_uc010oxi.1_5'Flank|uc001ehp.1_RNA|uc001eho.1_RNA|uc009whk.1_RNA	NM_015836	NP_056651	Q9UGM6	SYWM_HUMAN	mitochondrial tryptophanyl tRNA synthetase 2	18					tryptophanyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|tryptophan-tRNA ligase activity				0	all_neural(166;0.187)	all_lung(203;2.48e-06)|Lung NSC(69;1.74e-05)|all_epithelial(167;0.000564)		Lung(183;0.0629)	L-Tryptophan(DB00150)	TTATGAAGTGCCCGGATGAAG	0.597000													19	37					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145359169	145359169	+	Missense_Mutation	SNP	T	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr1:145359169T>A	uc001end.3	+	74	9369	c.9334T>A	c.(9334-9336)TTG>ATG	p.L3112M	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron|NBPF10_uc001enc.2_Intron|NBPF10_uc010oyq.1_Intron|NBPF10_uc010oyr.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3037											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GCGTGTTGGCTTGGCTGTTGA	0.458000													7	448					0	0	1	0	0
LRRN2	10446	broad.mit.edu	37	1	204587235	204587235	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr1:204587235G>A	uc001hbe.1	-	3	2274	c.1886C>T	c.(1885-1887)CCT>CTT	p.P629L	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Missense_Mutation_p.P629L|LRRN2_uc009xbf.1_Missense_Mutation_p.P629L|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	629	Extracellular (Potential).				cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			AATGAGCCCAGGACGGTCCCC	0.627000													6	33					0	0	1	0	0
PM20D1	148811	broad.mit.edu	37	1	205819185	205819185	+	Missense_Mutation	SNP	C	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr1:205819185C>A	uc001hdj.2	-	1	61	c.16G>T	c.(16-18)GTT>TTT	p.V6F	PM20D1_uc009xbr.2_RNA	NM_152491	NP_689704	Q6GTS8	P20D1_HUMAN	peptidase M20 domain containing 1 precursor	6						extracellular region	metal ion binding|peptidase activity			skin(1)	1	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			AGCACGCAAACGCACCGCTGA	0.602000													11	41					0.00136819	0.00138041	1	1	0
OR13G1	441933	broad.mit.edu	37	1	247835572	247835572	+	Missense_Mutation	SNP	G	T	T	rs117404602	by1000genomes	TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr1:247835572G>T	uc001idi.1	-	1	772	c.772C>A	c.(772-774)CGC>AGC	p.R258S		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	258	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GAAGCAGGGCGGATATAGGTG	0.463000													43	49					4.44401e-20	4.64975e-20	1	1	0
PRF1	5551	broad.mit.edu	37	10	72358728	72358728	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr10:72358728G>A	uc009xqg.2	-	3	910	c.749C>T	c.(748-750)ACG>ATG	p.T250M	PRF1_uc001jrf.3_Missense_Mutation_p.T250M	NM_001083116	NP_001076585	P14222	PERF_HUMAN	perforin 1 precursor	250	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						CTCGTTGTCCGTGAGCCCTTC	0.637000			M			various leukaemia|lymphoma	Type 2 familial hemophagocytic lymphohistiocytosis		Familial_Hemophagocytic_Lymphohistiocytosis				31	36					0	0	1	0	0
IDE	3416	broad.mit.edu	37	10	94266256	94266256	+	Silent	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr10:94266256C>T	uc001kia.2	-	10	1345	c.1269G>A	c.(1267-1269)AGG>AGA	p.R423R		NM_004969	NP_004960	P14735	IDE_HUMAN	insulin-degrading enzyme isoform 1 precursor	423					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGTCTTTAAACCTAAAAGCAA	0.343000													5	115					0	0	1	0	0
BTRC	8945	broad.mit.edu	37	10	103281443	103281443	+	Silent	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr10:103281443G>A	uc001kta.2	+	5	485	c.372G>A	c.(370-372)CGG>CGA	p.R124R	BTRC_uc001ktb.2_Silent_p.R88R|BTRC_uc001ktc.2_Silent_p.R98R	NM_033637	NP_378663	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing protein	124					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		CCAAGCAACGGAAACTCTCAG	0.388000													5	64					0	0	1	0	0
MS4A8B	83661	broad.mit.edu	37	11	60476228	60476228	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr11:60476228G>A	uc001npv.2	+	5	711	c.508G>A	c.(508-510)GAC>AAC	p.D170N	MS4A8B_uc009yne.1_Missense_Mutation_p.D170N	NM_031457	NP_113645	Q9BY19	M4A8B_HUMAN	membrane-spanning 4-domains, subfamily A, member	170	Extracellular (Potential).					integral to membrane	receptor activity				0						TGCCTACCCCGACTATTATCC	0.463000													17	88					0	0	1	0	0
P2RY2	5029	broad.mit.edu	37	11	72945337	72945337	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr11:72945337G>A	uc001otj.2	+	3	466	c.133G>A	c.(133-135)GTG>ATG	p.V45M	P2RY2_uc001otk.2_Missense_Mutation_p.V45M|P2RY2_uc001otl.2_Missense_Mutation_p.V45M	NM_002564	NP_002555	P41231	P2RY2_HUMAN	purinergic receptor P2Y2	45	Helical; Name=1; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(1)|skin(1)	4					Suramin(DB04786)	CGTGGTGTGCGTGCCTGGGCT	0.587000													17	146					0	0	1	0	0
CEP164	22897	broad.mit.edu	37	11	117266823	117266823	+	Missense_Mutation	SNP	T	C	C			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr11:117266823T>C	uc001prc.2	+	25	3290	c.3143T>C	c.(3142-3144)GTT>GCT	p.V1048A	CEP164_uc001prb.2_Missense_Mutation_p.V1051A|CEP164_uc010rxk.1_Missense_Mutation_p.V1022A|CEP164_uc001prf.2_Intron|CEP164_uc009yzp.1_RNA|CEP164_uc001prg.1_Missense_Mutation_p.V481A	NM_014956	NP_055771	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	1048					cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		GAAGTGACAGTTGAGGAAAAT	0.552000													47	180					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26752943	26752943	+	Missense_Mutation	SNP	G	C	C			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr12:26752943G>C	uc001rhg.2	-	29	4195	c.3778C>G	c.(3778-3780)CTG>GTG	p.L1260V		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	1260	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					AACAAATTCAGATGTTTATGA	0.328000													9	38					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29600162	29600162	+	Missense_Mutation	SNP	A	G	G			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr13:29600162A>G	uc001usl.3	+	1	1415	c.1357A>G	c.(1357-1359)AAT>GAT	p.N453D		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	443						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						TATTCCTAATAATCTGACTGA	0.473000													17	48					0	0	1	0	0
KTN1	3895	broad.mit.edu	37	14	56117347	56117347	+	Missense_Mutation	SNP	G	A	A	rs148189219		TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr14:56117347G>A	uc001xcb.2	+	25	2859	c.2557G>A	c.(2557-2559)GCT>ACT	p.A853T	KTN1_uc001xce.2_Missense_Mutation_p.A853T|KTN1_uc001xcc.2_Missense_Mutation_p.A853T|KTN1_uc001xcd.2_Intron|KTN1_uc010trb.1_Missense_Mutation_p.A853T|KTN1_uc001xcf.1_Intron|KTN1_uc010aoq.2_Missense_Mutation_p.A148T	NM_182926	NP_891556	Q86UP2	KTN1_HUMAN	kinectin 1 isoform a	853	Lumenal (Potential).|Potential.				microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(3)|ovary(2)|lung(1)|central_nervous_system(1)	7						GCTTGAAAAGGCTCAACAGGT	0.328000			T	RET	papillary thryoid								5	80					0	0	1	0	0
TYRO3	7301	broad.mit.edu	37	15	41865634	41865634	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr15:41865634C>T	uc001zof.1	+	17	2338	c.2114C>T	c.(2113-2115)GCC>GTC	p.A705V		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	705	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GAGAGCCTGGCCGACAACCTG	0.582000													4	172					0	0	1	0	0
TCF12	6938	broad.mit.edu	37	15	57543547	57543547	+	Splice_Site	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr15:57543547G>A	uc002aec.2	+	14	1399	c.1115_splice	c.e14-1	p.G372_splice	TCF12_uc010ugm.1_Splice_Site_p.G424_splice|TCF12_uc010ugn.1_Splice_Site_p.G368_splice|TCF12_uc002aea.2_Splice_Site_p.G372_splice|TCF12_uc010bfs.2_Intron|TCF12_uc002aeb.2_Splice_Site_p.G372_splice|TCF12_uc002aed.2_Splice_Site_p.G372_splice|TCF12_uc002aee.2_Splice_Site_p.G202_splice|TCF12_uc010bft.2_Splice_Site_p.G202_splice|TCF12_uc010ugo.1_Splice_Site_p.G136_splice|TCF12_uc010ugp.1_Splice_Site_p.S6_splice|TCF12_uc010ugq.1_Splice_Site_p.S6_splice|TCF12_uc010ugr.1_5'Flank	NM_207038	NP_996921	Q99081	HTF4_HUMAN	transcription factor 12 isoform b						immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(2)|lung(1)	8		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		GGTTTTAACAGGTACCAGTCA	0.423000			T	TEC	extraskeletal myxoid chondrosarcoma								21	28					0	0	1	0	0
SLTM	79811	broad.mit.edu	37	15	59186365	59186365	+	Missense_Mutation	SNP	T	C	C			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr15:59186365T>C	uc002afp.2	-	11	1493	c.1405A>G	c.(1405-1407)ATG>GTG	p.M469V	SLTM_uc002afn.2_Missense_Mutation_p.M38V|SLTM_uc002afo.2_Missense_Mutation_p.M451V|SLTM_uc002afq.2_Missense_Mutation_p.M38V|SLTM_uc010bgd.2_Missense_Mutation_p.M38V	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	469					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						TCTTTCTTCATTTCTTTCTTA	0.294000													4	39					0	0	1	0	0
VPS13C	54832	broad.mit.edu	37	15	62254029	62254029	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr15:62254029C>T	uc002agz.2	-	35	3741	c.3667G>A	c.(3667-3669)GAA>AAA	p.E1223K	VPS13C_uc002aha.2_Missense_Mutation_p.E1180K|VPS13C_uc002ahb.1_Missense_Mutation_p.E1223K|VPS13C_uc002ahc.1_Missense_Mutation_p.E1180K	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	1223					protein localization					ovary(2)	2						GCAGCCCTTTCTGCAGCCTGG	0.448000													18	76					0	0	1	0	0
RGMA	56963	broad.mit.edu	37	15	93595609	93595609	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr15:93595609G>A	uc002bss.1	-	3	531	c.259C>T	c.(259-261)CGG>TGG	p.R87W	RGMA_uc002bsq.1_Missense_Mutation_p.R71W|RGMA_uc010boi.1_5'UTR|RGMA_uc002bsr.1_5'UTR|RGMA_uc010urc.1_Missense_Mutation_p.R95W	NM_020211	NP_064596	Q96B86	RGMA_HUMAN	RGM domain family, member A precursor	87					axon guidance	anchored to membrane|endoplasmic reticulum|plasma membrane					0	Lung NSC(78;0.0542)|all_lung(78;0.0786)		BRCA - Breast invasive adenocarcinoma(143;0.0312)|OV - Ovarian serous cystadenocarcinoma(32;0.108)			GCCGTCCGCCGCGTGCACAGG	0.677000													4	29					0	0	1	0	0
Unknown	0	broad.mit.edu	37	16	15457701	15457701	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr16:15457701G>A	uc010bvf.1	-	9	812	c.812C>T	c.(811-813)GCT>GTT	p.A271V						RecName: Full=NPIP-like protein 1;																		AGGGGAGTGAGCAGACACTCG	0.562000													5	207					0	0	1	0	0
CCDC102A	92922	broad.mit.edu	37	16	57550306	57550306	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr16:57550306C>T	uc002elw.2	-	7	1531	c.1318G>A	c.(1318-1320)GCA>ACA	p.A440T		NM_033212	NP_149989	Q96A19	C102A_HUMAN	coiled-coil domain containing 102A	440	Potential.									ovary(1)	1						TTGGCATGTGCCAGCTCTGCC	0.632000													3	39					0	0	1	0	0
Unknown	0	broad.mit.edu	37	16	70268158	70268158	+	RNA	SNP	A	C	C			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr16:70268158A>C	uc010cfp.1	-	3		c.257T>G								Homo sapiens cDNA, FLJ98908.																		TTCTTCATTAAAACAGCTACT	0.333000													5	19					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577121	7577121	+	Missense_Mutation	SNP	G	A	A	rs121913343		TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542000	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			35	9					0	0	1	0	0
CDK12	51755	broad.mit.edu	37	17	37627827	37627827	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr17:37627827C>T	uc010cvv.2	+	2	2328	c.1742C>T	c.(1741-1743)ACT>ATT	p.T581I	CDK12_uc010wef.1_Missense_Mutation_p.T580I|CDK12_uc002hrw.3_Missense_Mutation_p.T581I	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	581					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						GCTTCCAGTACTTCAACTTTG	0.507000										TCGA Ovarian(9;0.13)			13	253					0	0	1	0	0
Unknown	0	broad.mit.edu	37	17	45127272	45127272	+	Missense_Mutation	SNP	A	C	C			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr17:45127272A>C	uc010wkj.1	+	2	824	c.470A>C	c.(469-471)AAG>ACG	p.K157T	uc010wkl.1_RNA					SubName: Full=Putative uncharacterized protein LRRC37A3;																		ACAAATATGAAGGCTTCTAAA	0.428000													9	125					0	0	1	0	0
GH1	2688	broad.mit.edu	37	17	61995729	61995729	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr17:61995729C>T	uc002jdj.2	-	2	210	c.148G>A	c.(148-150)GCC>ACC	p.A50T	GH1_uc002jdi.2_Missense_Mutation_p.A50T|GH1_uc002jdk.2_Missense_Mutation_p.A50T|GH1_uc002jdl.2_Missense_Mutation_p.A50T|GH1_uc002jdm.2_Intron|GH1_uc002jdn.2_Missense_Mutation_p.A50T	NM_000515	NP_000506	P01241	SOMA_HUMAN	growth hormone 1 isoform 1	50					glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding				0						GTGTCAAAGGCCAGCTGGTGC	0.582000													63	255					0	0	1	0	0
TUBB6	84617	broad.mit.edu	37	18	12325927	12325927	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr18:12325927G>A	uc002kqw.2	+	4	1184	c.1139G>A	c.(1138-1140)CGC>CAC	p.R380H	TUBB6_uc002kqv.2_Missense_Mutation_p.R308H|TUBB6_uc002kqx.2_Missense_Mutation_p.R343H|TUBB6_uc002kqy.2_Intron	NM_032525	NP_115914	Q9BUF5	TBB6_HUMAN	tubulin, beta 6	380					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0				READ - Rectum adenocarcinoma(1;0.0649)		CTGTTCAAGCGCATCTCCGAG	0.617000													5	272					0	0	1	0	0
CTAGE1	64693	broad.mit.edu	37	18	19997797	19997797	+	Translation_Start_Site	SNP	A	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr18:19997797A>T	uc002ktv.1	-	1	82	c.-22T>A	c.(-24--20)GGTTG>GGATG			NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1							integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					TGCTGCCACAACCCTGCGTAG	0.547000													5	30					0	0	1	0	0
GALR1	2587	broad.mit.edu	37	18	74980584	74980584	+	Missense_Mutation	SNP	C	G	G			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr18:74980584C>G	uc002lms.3	+	3	1273	c.776C>G	c.(775-777)TCC>TGC	p.S259C		NM_001480	NP_001471	P47211	GALR1_HUMAN	galanin receptor 1	259	Helical; Name=6; (Potential).				digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			lung(1)	1		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		TTTGGAATCTCCTGGCTGCCG	0.423000													40	172					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1044692	1044692	+	Silent	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr19:1044692C>T	uc002lqw.3	+	11	1395	c.1164C>T	c.(1162-1164)GAC>GAT	p.D388D	ABCA7_uc010dsb.1_Silent_p.D250D	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	388	Extracellular (By similarity).				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGGCAGGACGCACACGCTG	0.667000													10	46					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9090831	9090831	+	Silent	SNP	A	G	G			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr19:9090831A>G	uc002mkp.2	-	1	1188	c.984T>C	c.(982-984)CCT>CCC	p.P328P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	328	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCATGGAAAAAGGGATAGCTG	0.522000													3	116					0	0	1	0	0
OR7A17	26333	broad.mit.edu	37	19	14992008	14992008	+	Missense_Mutation	SNP	G	C	C			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr19:14992008G>C	uc010xob.1	-	1	160	c.160C>G	c.(160-162)CAC>GAC	p.H54D		NM_030901	NP_112163	O14581	OR7AH_HUMAN	olfactory receptor, family 7, subfamily A,	54	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					GTGTGGAGGTGGGAGTCTGAG	0.502000													6	111					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	31038967	31038967	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr19:31038967G>A	uc002nsu.1	+	4	2579	c.2441G>A	c.(2440-2442)GGG>GAG	p.G814E	ZNF536_uc010edd.1_Missense_Mutation_p.G814E	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	814					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CCGCTGTCTGGGCAACCCCCA	0.572000													5	139					0	0	1	0	0
PRR19	284338	broad.mit.edu	37	19	42813898	42813898	+	Silent	SNP	G	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr19:42813898G>T	uc002oti.2	+	2	540	c.162G>T	c.(160-162)GTG>GTT	p.V54V	PRR19_uc002oth.1_Silent_p.V54V|PRR19_uc002otj.2_Silent_p.V54V	NM_199285	NP_954979	A6NJB7	PRR19_HUMAN	proline rich 19	54											0		Prostate(69;0.00682)				ATCCACCTGTGGTCCCTACTG	0.622000													9	128					5.4927e-09	5.6425e-09	1	1	0
ZNF613	79898	broad.mit.edu	37	19	52447902	52447902	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr19:52447902G>A	uc002pxz.1	+	6	1189	c.766G>A	c.(766-768)GGA>AGA	p.G256R	ZNF613_uc002pya.1_Missense_Mutation_p.G220R	NM_001031721	NP_001026891	Q6PF04	ZN613_HUMAN	zinc finger protein 613 isoform 1	256					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.0183)		AAACCACACAGGAGAGAAACC	0.458000													49	103					0	0	1	0	0
TMEM131	23505	broad.mit.edu	37	2	98388789	98388789	+	Silent	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr2:98388789C>T	uc002syh.3	-	33	4648	c.4419G>A	c.(4417-4419)AAG>AAA	p.K1473K		NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	1473	Lys-rich.					integral to membrane				ovary(4)|central_nervous_system(2)	6						GGATTTCTTTCTTAATATTTA	0.363000													5	146					0	0	1	0	0
CNGA3	1261	broad.mit.edu	37	2	99006190	99006190	+	Silent	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr2:99006190C>T	uc002syt.2	+	6	936	c.519C>T	c.(517-519)ACC>ACT	p.T173T	CNGA3_uc002syu.2_Silent_p.T155T|CNGA3_uc010fij.2_Silent_p.T177T	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	173	Helical; (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						GCTGGCTGACCGCCATCGCCC	0.557000													15	116					0	0	1	0	0
IL1B	3553	broad.mit.edu	37	2	113591147	113591147	+	Silent	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr2:113591147G>A	uc002tii.1	-	4	192	c.105C>T	c.(103-105)TCC>TCT	p.S35S	IL1B_uc002tih.1_Silent_p.S4S	NM_000576	NP_000567	P01584	IL1B_HUMAN	interleukin 1, beta proprotein	35					activation of MAPK activity|anti-apoptosis|apoptosis|cell-cell signaling|cellular response to drug|cellular response to mechanical stimulus|cytokine-mediated signaling pathway|embryo implantation|fever generation|negative regulation of adiponectin secretion|negative regulation of cell proliferation|negative regulation of glucose transport|negative regulation of insulin receptor signaling pathway|negative regulation of lipid catabolic process|negative regulation of MAP kinase activity|positive regulation of angiogenesis|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of cell adhesion molecule production|positive regulation of cell division|positive regulation of fever generation|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of interferon-gamma production|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of lipid catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mitosis|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myosin light chain kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|positive regulation of protein export from nucleus|positive regulation of T cell proliferation|positive regulation vascular endothelial growth factor production|regulation of insulin secretion|sequestering of triglyceride|smooth muscle adaptation	cytosol|extracellular space	cytokine activity|growth factor activity|interleukin-1 receptor binding|protein domain specific binding			lung(3)|breast(1)	4					Anakinra(DB00026)|Minocycline(DB01017)|Procaterol(DB01366)	GGTCCTGGAAGGAGCACTGCG	0.597000													24	79					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116538514	116538514	+	Missense_Mutation	SNP	A	G	G			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr2:116538514A>G	uc002tla.1	+	16	1883	c.1426A>G	c.(1426-1428)ACA>GCA	p.T476A	DPP10_uc002tlb.1_Missense_Mutation_p.T426A|DPP10_uc002tlc.1_Missense_Mutation_p.T472A|DPP10_uc002tle.2_Missense_Mutation_p.T480A|DPP10_uc002tlf.1_Missense_Mutation_p.T469A	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	476	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						AGAACAATGTACATATTTTGA	0.284000													32	57					0	0	1	0	0
CCDC93	54520	broad.mit.edu	37	2	118731539	118731539	+	Missense_Mutation	SNP	A	G	G			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr2:118731539A>G	uc002tlj.2	-	11	959	c.833T>C	c.(832-834)ATT>ACT	p.I278T	CCDC93_uc010fld.1_Missense_Mutation_p.I278T	NM_019044	NP_061917	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	278	Potential.									large_intestine(1)|ovary(1)	2						GAGTCCCACAATCTGGCCCAC	0.537000													15	11					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152374910	152374910	+	Missense_Mutation	SNP	C	G	G			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr2:152374910C>G	uc010fnx.2	-	128	17810	c.17619G>C	c.(17617-17619)AAG>AAC	p.K5873N	NEB_uc002txr.2_Missense_Mutation_p.K2296N|NEB_uc002txt.3_Missense_Mutation_p.K378N	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5873	Nebulin 160.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GGCCTTTACTCTTCTCATACT	0.433000													9	311					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152376199	152376199	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr2:152376199C>T	uc010fnx.2	-	126	17651	c.17460G>A	c.(17458-17460)ATG>ATA	p.M5820I	NEB_uc002txr.2_Missense_Mutation_p.M2243I|NEB_uc002txt.3_Missense_Mutation_p.M325I	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5820	Nebulin 159.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TAGCATCTTTCATGACTTTGT	0.244000													10	118					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								22	63					0	0	1	0	0
BCAS1	8537	broad.mit.edu	37	20	52611567	52611567	+	Missense_Mutation	SNP	T	C	C			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr20:52611567T>C	uc002xws.2	-	6	1249	c.911A>G	c.(910-912)AAG>AGG	p.K304R	BCAS1_uc010zza.1_Missense_Mutation_p.K17R|BCAS1_uc010zzb.1_Missense_Mutation_p.K207R|BCAS1_uc010gim.2_Missense_Mutation_p.K207R|BCAS1_uc002xwt.2_Missense_Mutation_p.K304R|BCAS1_uc010gil.1_Missense_Mutation_p.K304R	NM_003657	NP_003648	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	304						cytoplasm	protein binding			ovary(2)|central_nervous_system(1)	3	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			TTCTGGGTCCTTTTTTGTTTC	0.338000													4	250					0	0	1	0	0
USP25	29761	broad.mit.edu	37	21	17250117	17250117	+	Silent	SNP	A	G	G			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr21:17250117A>G	uc002yjy.1	+	23	3019	c.2802A>G	c.(2800-2802)AAA>AAG	p.K934K	USP25_uc011aby.1_Silent_p.K1004K|USP25_uc002yjz.1_Silent_p.K966K|USP25_uc010gla.1_Silent_p.K329K	NM_013396	NP_037528	Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	934					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		GCATTAAGAAATTAAATGAGC	0.313000													5	9					0	0	1	0	0
PFKL	5211	broad.mit.edu	37	21	45746603	45746603	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr21:45746603G>A	uc002zel.2	+	22	2260	c.2201G>A	c.(2200-2202)CGC>CAC	p.R734H	PFKL_uc002zek.2_Missense_Mutation_p.R781H|PFKL_uc002zem.2_Missense_Mutation_p.R321H|PFKL_uc002zen.2_Missense_Mutation_p.R321H	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	734					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)		CACAGGCACCGCATGCCACGG	0.667000													3	8					0	0	1	0	0
ITGB2	3689	broad.mit.edu	37	21	46309270	46309270	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr21:46309270C>T	uc002zgd.2	-	12	1842	c.1798G>A	c.(1798-1800)GTA>ATA	p.V600I	ITGB2_uc002zge.2_Missense_Mutation_p.V600I|ITGB2_uc002zgf.3_Missense_Mutation_p.V600I|ITGB2_uc011afl.1_Missense_Mutation_p.V522I|ITGB2_uc010gpw.2_Missense_Mutation_p.V543I|ITGB2_uc002zgg.2_Missense_Mutation_p.V600I	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	600	Extracellular (Potential).|Cysteine-rich tandem repeats.|IV.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	CACTCGCATACGTTGCAGCGG	0.657000													3	37					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18301254	18301254	+	Silent	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr22:18301254C>T	uc002zng.3	-	26	4526	c.4173G>A	c.(4171-4173)CTG>CTA	p.L1391L	MICAL3_uc011agl.1_Silent_p.L1307L|MICAL3_uc010gre.1_5'Flank	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	1391	Pro-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		CCGGCTTTGGCAGGCCCAGCC	0.632000													5	281					0	0	1	0	0
TEF	7008	broad.mit.edu	37	22	41783620	41783620	+	Silent	SNP	A	G	G			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr22:41783620A>G	uc003azy.2	+	2	509	c.423A>G	c.(421-423)CCA>CCG	p.P141P	TEF_uc003azx.2_Silent_p.P111P|TEF_uc011apa.1_Silent_p.P146P	NM_003216	NP_003207	Q10587	TEF_HUMAN	thyrotrophic embryonic factor isoform 1	141					rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CAGCATCCCCACCATCCTCCT	0.612000													25	44					0	0	1	0	0
SETMAR	6419	broad.mit.edu	37	3	4354791	4354791	+	Silent	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr3:4354791C>T	uc011asp.1	+	2	433	c.366C>T	c.(364-366)TGC>TGT	p.C122C	SUMF1_uc003bps.1_Intron|SETMAR_uc003bpw.3_Silent_p.C109C|SETMAR_uc003bpy.3_Intron|SETMAR_uc011asq.1_Silent_p.C109C|SETMAR_uc011asr.1_Missense_Mutation_p.A12V|SETMAR_uc010hbx.2_5'UTR	NM_006515	NP_006506	Q53H47	SETMR_HUMAN	SET domain and mariner transposase fusion	109	Pre-SET.|Histone-lysine N-methyltransferase.				DNA integration|DNA repair|transposition, DNA-mediated	chromosome|nucleus	DNA binding|endonuclease activity|histone-lysine N-methyltransferase activity|transposase activity|zinc ion binding			ovary(1)	1		Melanoma(143;0.0657)		Epithelial(13;0.0025)|OV - Ovarian serous cystadenocarcinoma(96;0.011)|all cancers(10;0.0114)		ATGTCCTGTGCCGATGCAGTG	0.468000								Chromatin_Structure|Direct_reversal_of_damage					3	42					0	0	1	0	0
OR5H2	79310	broad.mit.edu	37	3	98002530	98002530	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr3:98002530C>T	uc003dsj.1	+	1	799	c.799C>T	c.(799-801)CCT>TCT	p.P267S		NM_001005482	NP_001005482	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						GTATTTGCGCCCTGCATCTCC	0.398000													11	80					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	121980530	121980530	+	Silent	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr3:121980530C>T	uc003eev.3	+	4	1020	c.648C>T	c.(646-648)GAC>GAT	p.D216D	CASR_uc003eew.3_Silent_p.D216D	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	216	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CAGCTGATGACGACTATGGGC	0.537000													16	192					0	0	1	0	0
TMCC1	23023	broad.mit.edu	37	3	129389499	129389499	+	Silent	SNP	T	C	C			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr3:129389499T>C	uc003emz.3	-	5	1686	c.1185A>G	c.(1183-1185)GAA>GAG	p.E395E	TMCC1_uc003emy.3_Silent_p.E71E|TMCC1_uc011blc.1_Silent_p.E216E|TMCC1_uc010htg.2_Silent_p.E281E	NM_001017395	NP_001017395	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	395						integral to membrane				skin(1)	1						CCACTTGCCCTTCCTCTAAAG	0.478000													9	98					0	0	1	0	0
RNF168	165918	broad.mit.edu	37	3	196229803	196229803	+	Missense_Mutation	SNP	T	C	C			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr3:196229803T>C	uc003fwq.2	-	1	780	c.242A>G	c.(241-243)CAA>CGA	p.Q81R	RNF168_uc010iah.2_5'UTR	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	81					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		ATAGTGTTTTTGAATTATCGT	0.512000													32	57					0	0	1	0	0
PDHA2	5161	broad.mit.edu	37	4	96762461	96762461	+	Missense_Mutation	SNP	T	C	C			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr4:96762461T>C	uc003htr.3	+	1	1223	c.1160T>C	c.(1159-1161)GTC>GCC	p.V387A		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	387					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	TTTAAGTCCGTCAGTTAAAGG	0.398000													44	63					0	0	1	0	0
EGF	1950	broad.mit.edu	37	4	110895897	110895897	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr4:110895897G>A	uc003hzy.3	+	12	2215	c.1763G>A	c.(1762-1764)CGT>CAT	p.R588H	EGF_uc011cfu.1_Missense_Mutation_p.R546H|EGF_uc011cfv.1_Missense_Mutation_p.R588H	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	588	LDL-receptor class B 7.|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	AATGGGAAACGTTCCAAAATA	0.353000													12	34					0	0	1	0	0
MYO10	4651	broad.mit.edu	37	5	16694556	16694556	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr5:16694556G>A	uc003jft.3	-	27	4192	c.3724C>T	c.(3724-3726)CGC>TGC	p.R1242C	MYO10_uc011cnc.1_Missense_Mutation_p.R121C|MYO10_uc011cnd.1_Missense_Mutation_p.R599C|MYO10_uc011cne.1_Missense_Mutation_p.R599C|MYO10_uc010itx.2_Missense_Mutation_p.R865C	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1242	PH 1.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						TTGGACTGGCGGAGGACAAAC	0.567000													4	221					0	0	1	0	0
IL6ST	3572	broad.mit.edu	37	5	55250757	55250757	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr5:55250757G>A	uc003jqq.2	-	11	1586	c.1331C>T	c.(1330-1332)ACT>ATT	p.T444I	IL6ST_uc010iwb.2_Intron|IL6ST_uc010iwc.2_Intron|IL6ST_uc010iwd.2_Intron|IL6ST_uc011cqk.1_Missense_Mutation_p.T155I|IL6ST_uc003jqr.2_3'UTR	NM_002184	NP_002175	P40189	IL6RB_HUMAN	interleukin 6 signal transducer isoform 1	444	Extracellular (Potential).|Fibronectin type-III 4.				interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity			large_intestine(1)|ovary(1)	2		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)				CCTTGGAGTAGTCCATTCCAC	0.368000			O		hepatocellular ca								9	216					0	0	1	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140769361	140769361	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr5:140769361G>A	uc003lkc.1	+	1	1910	c.1910G>A	c.(1909-1911)CGC>CAC	p.R637H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.R637H	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	637	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACGCCGTCCGCCAGCGCCTT	0.692000													19	46					0	0	1	0	0
DHX16	8449	broad.mit.edu	37	6	30632747	30632747	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr6:30632747G>A	uc003nqz.2	-	7	1360	c.1148C>T	c.(1147-1149)TCA>TTA	p.S383L	DHX16_uc003nqy.2_5'Flank|DHX16_uc011dmo.1_Missense_Mutation_p.S323L	NM_003587	NP_003578	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	383					mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(2)|kidney(2)	4						GGCCTGAGTTGAAGTGGGTGG	0.567000													6	55					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32038129	32038129	+	Missense_Mutation	SNP	G	C	C			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr6:32038129G>C	uc003nzl.2	-	14	5255	c.5053C>G	c.(5053-5055)CCC>GCC	p.P1685A		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1767	Fibronectin type-III 10.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TCTGGGGTGGGGTCTGTCACC	0.602000													5	36					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46803179	46803179	+	Silent	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr6:46803179C>T	uc010jzh.1	+	13	2019	c.1977C>T	c.(1975-1977)GGC>GGT	p.G659G	MEP1A_uc011dwg.1_Silent_p.G381G|MEP1A_uc011dwh.1_Silent_p.G687G|MEP1A_uc011dwi.1_Silent_p.G559G	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	659	Extracellular (Potential).				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			AGAACACAGGCCCCCTGGAGG	0.587000													3	21					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4026875	4026875	+	Silent	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr7:4026875C>T	uc003smx.2	+	14	2191	c.2052C>T	c.(2050-2052)CAC>CAT	p.H684H		NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	684	Fibronectin type-III 1.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CCCACAGCCACGCCGTGGTGC	0.458000													19	157					0	0	1	0	0
DPY19L2P1	554236	broad.mit.edu	37	7	35131480	35131480	+	Missense_Mutation	SNP	A	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr7:35131480A>T	uc003teq.1	-	20	2213	c.1106T>A	c.(1105-1107)CTT>CAT	p.L369H	DPY19L2P1_uc003tep.1_RNA|DPY19L2P1_uc010kwz.1_RNA					RecName: Full=Protein dpy-19 homolog 2-like 2; AltName: Full=Dpy-19-like protein 2 pseudogene 2;												0						ATCTTCGTAAAGTGGATGATT	0.408000													5	98					0	0	1	0	0
CDC14C	168448	broad.mit.edu	37	7	48964537	48964537	+	Missense_Mutation	SNP	A	G	G			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr7:48964537A>G	uc010kyv.1	+	1	381	c.269A>G	c.(268-270)CAT>CGT	p.H90R		NR_003595				SubName: Full=Putative uncharacterized protein MGC26484;												0						AAAATTGTTCATTTTACTGGC	0.373000													4	100					0	0	1	0	0
CDHR3	222256	broad.mit.edu	37	7	105669001	105669001	+	Silent	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr7:105669001G>A	uc003vdl.3	+	17	2385	c.2277G>A	c.(2275-2277)ACG>ACA	p.T759T	CDHR3_uc003vdk.2_Missense_Mutation_p.E191K|CDHR3_uc003vdm.3_Silent_p.T746T|CDHR3_uc011klt.1_Silent_p.T671T|CDHR3_uc003vdn.2_Missense_Mutation_p.E260K	NM_152750	NP_689963	Q6ZTQ4	CDHR3_HUMAN	hypothetical protein LOC222256 precursor	759	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						CTGCAGAAACGAAGACTGCAG	0.537000													19	32					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128488741	128488741	+	Silent	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr7:128488741G>A	uc003vnz.3	+	27	4916	c.4707G>A	c.(4705-4707)GCG>GCA	p.A1569A	FLNC_uc003voa.3_Silent_p.A1569A	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1569	Filamin 14.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CACGGGACGCGGGCGAGGGGT	0.657000													4	184					0	0	1	0	0
ZC3HAV1L	92092	broad.mit.edu	37	7	138711561	138711561	+	Missense_Mutation	SNP	G	C	C			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr7:138711561G>C	uc003vum.1	-	4	791	c.779C>G	c.(778-780)ACT>AGT	p.T260S		NM_080660	NP_542391	Q96H79	ZCCHL_HUMAN	zinc finger CCCH-type, antiviral 1-like	260											0						TGAATGCTCAGTCGAAGGTGA	0.517000													9	49					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12946019	12946019	+	Silent	SNP	A	C	C			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr8:12946019A>C	uc003wwm.2	-	16	4713	c.4269T>G	c.(4267-4269)CCT>CCG	p.P1423P	DLC1_uc003wwk.1_Silent_p.P986P|DLC1_uc003wwl.1_Silent_p.P1020P|DLC1_uc011kxx.1_Silent_p.P912P	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	1423	START.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						AGTCTCGAGCAGGATGAGGTG	0.423000													18	93					0	0	1	0	0
MTUS1	57509	broad.mit.edu	37	8	17581236	17581236	+	Silent	SNP	T	G	G			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr8:17581236T>G	uc003wxv.2	-	4	2868	c.2394A>C	c.(2392-2394)GGA>GGC	p.G798G	MTUS1_uc003wxt.2_5'Flank|MTUS1_uc011kyg.1_5'Flank|MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Intron|MTUS1_uc010lsz.2_Silent_p.G798G	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	798						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		AGGGGGTGCTTCCTGTCCTCC	0.483000													14	112					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18393458	18393458	+	Missense_Mutation	SNP	T	C	C			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr8:18393458T>C	uc003wza.2	-	16	3042	c.2939A>G	c.(2938-2940)TAT>TGT	p.Y980C	PSD3_uc003wyx.3_Missense_Mutation_p.Y309C|PSD3_uc003wyy.2_Missense_Mutation_p.Y446C|PSD3_uc003wyz.2_Missense_Mutation_p.Y281C	NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	981					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		ATACATTTCATAGCGGGTTTT	0.483000													13	86					0	0	1	0	0
C8orf41	80185	broad.mit.edu	37	8	33357852	33357852	+	Silent	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr8:33357852C>T	uc003xjl.3	-	6	1941	c.1416G>A	c.(1414-1416)CGG>CGA	p.R472R	C8orf41_uc010lvu.1_RNA|MAK16_uc003xjj.2_3'UTR|C8orf41_uc003xjk.3_Silent_p.R441R|C8orf41_uc010lvv.2_Intron|C8orf41_uc003xjm.3_Silent_p.R472R	NM_025115	NP_079391	Q6NXR4	CH041_HUMAN	hypothetical protein LOC80185	472							binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0923)|Kidney(114;0.111)		TTACCTTTACCCGTCCTTGAG	0.463000													3	49					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35406823	35406823	+	Silent	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr8:35406823C>T	uc003xjr.1	+	2	445	c.117C>T	c.(115-117)GGC>GGT	p.G39G	UNC5D_uc003xjs.1_Silent_p.G34G	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	39	Extracellular (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CTGACAATGGCGAAGCCCTTC	0.468000													24	47					0	0	1	0	0
RBM12B	389677	broad.mit.edu	37	8	94747027	94747027	+	Missense_Mutation	SNP	C	G	G			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr8:94747027C>G	uc003yfz.2	-	3	1805	c.1612G>C	c.(1612-1614)GAT>CAT	p.D538H		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	538							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			TTGAAGTTATCCAGTTGCCTC	0.493000													19	122					0	0	1	0	0
RBM12B	389677	broad.mit.edu	37	8	94747221	94747221	+	Missense_Mutation	SNP	C	G	G			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr8:94747221C>G	uc003yfz.2	-	3	1611	c.1418G>C	c.(1417-1419)AGA>ACA	p.R473T		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	473	RRM 3.						nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			AGATATAAGTCTTAATAACAC	0.423000													35	211					0	0	1	0	0
RBM12B	389677	broad.mit.edu	37	8	94747336	94747336	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr8:94747336C>T	uc003yfz.2	-	3	1496	c.1303G>A	c.(1303-1305)GAT>AAT	p.D435N		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	435	RRM 3.						nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			CCTTTGTCATCATAAAGCAAG	0.373000													32	165					0	0	1	0	0
RBM12B	389677	broad.mit.edu	37	8	94747712	94747712	+	Silent	SNP	C	G	G			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr8:94747712C>G	uc003yfz.2	-	3	1120	c.927G>C	c.(925-927)CTG>CTC	p.L309L		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	309	RRM 2.						nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			GTTCATCAGTCAGATCAGTAC	0.343000													12	67					0	0	1	0	0
RBM12B	389677	broad.mit.edu	37	8	94747854	94747854	+	Missense_Mutation	SNP	C	G	G			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr8:94747854C>G	uc003yfz.2	-	3	978	c.785G>C	c.(784-786)AGA>ACA	p.R262T		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	262							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			TCGAAAATGTCTATCATTAAT	0.398000													12	105					0	0	1	0	0
RBM12B	389677	broad.mit.edu	37	8	94747893	94747893	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr8:94747893C>T	uc003yfz.2	-	3	939	c.746G>A	c.(745-747)AGA>AAA	p.R249K		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	249							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			TTCTTCAGATCTCCTAAGAAC	0.398000													11	134					0	0	1	0	0
RBM12B	389677	broad.mit.edu	37	8	94747940	94747940	+	Missense_Mutation	SNP	C	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr8:94747940C>A	uc003yfz.2	-	3	892	c.699G>T	c.(697-699)TGG>TGT	p.W233C		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	233							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			CAAACTCAATCCACTGTTGTT	0.373000													21	133					6.44725e-10	6.68385e-10	1	1	0
RBM12B	389677	broad.mit.edu	37	8	94747956	94747956	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr8:94747956C>T	uc003yfz.2	-	3	876	c.683G>A	c.(682-684)GGA>GAA	p.G228E		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	228	RRM 1.						nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			TTGTTCTGATCCTTGCATTAC	0.383000													20	147					0	0	1	0	0
RBM12B	389677	broad.mit.edu	37	8	94748053	94748053	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr8:94748053C>T	uc003yfz.2	-	3	779	c.586G>A	c.(586-588)GAT>AAT	p.D196N		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	196	RRM 1.						nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			ACTATGGCATCACCATTATTT	0.363000													18	136					0	0	1	0	0
RBM12B	389677	broad.mit.edu	37	8	94748131	94748131	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr8:94748131C>T	uc003yfz.2	-	3	701	c.508G>A	c.(508-510)GAT>AAT	p.D170N		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	170	RRM 1.						nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			ACACGTACATCATCTTCATTT	0.393000													11	74					0	0	1	0	0
NACAP1	83955	broad.mit.edu	37	8	102381123	102381123	+	Translation_Start_Site	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr8:102381123C>T	uc003ykc.1	+	1	3	c.-14C>T	c.(-16--12)CACGT>CATGT		NACAP1_uc010mbs.1_RNA	NR_002182				SubName: Full=NACAP1 protein;												0						CTTGATTCCACGTTCCCTCCA	0.542000													3	34					0	0	1	0	0
UNC13B	10497	broad.mit.edu	37	9	35366984	35366984	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr9:35366984C>T	uc003zwq.2	+	11	1500	c.1208C>T	c.(1207-1209)CCG>CTG	p.P403L	UNC13B_uc010mkl.1_Missense_Mutation_p.R411W|UNC13B_uc003zwr.2_Missense_Mutation_p.P403L|UNC13B_uc010mkm.1_RNA	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	403					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			CAGTGGCTCCCGGAAGGGTAA	0.448000													39	48					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94495542	94495542	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr9:94495542C>T	uc004arj.1	-	6	998	c.799G>A	c.(799-801)GAG>AAG	p.E267K	ROR2_uc004ari.1_Missense_Mutation_p.E127K|ROR2_uc004ark.2_Missense_Mutation_p.E267K	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	267	FZ.|Extracellular (Potential).				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						ATGGTGTACTCCTGGCGGCAC	0.672000													7	27					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109689383	109689383	+	Nonsense_Mutation	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr9:109689383C>T	uc004bcz.2	+	3	3479	c.3190C>T	c.(3190-3192)CAG>TAG	p.Q1064*	ZNF462_uc010mto.2_Nonsense_Mutation_p.Q912*|ZNF462_uc004bda.2_Nonsense_Mutation_p.Q912*	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	1064					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						CTTTAGGATCCAGAAAACTAT	0.453000													12	124					0	0	1	0	0
RGS3	5998	broad.mit.edu	37	9	116358026	116358026	+	Missense_Mutation	SNP	C	T	T	rs144334750		TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr9:116358026C>T	uc004bhq.2	+	25	3601	c.3392C>T	c.(3391-3393)GCG>GTG	p.A1131V	RGS3_uc004bhs.2_Missense_Mutation_p.A1021V|RGS3_uc004bht.2_Missense_Mutation_p.A850V|RGS3_uc010muy.2_Missense_Mutation_p.A524V|RGS3_uc004bhv.2_Missense_Mutation_p.A452V|RGS3_uc004bhw.2_Missense_Mutation_p.A101V|RGS3_uc011lxh.1_Missense_Mutation_p.A441V|RGS3_uc004bhx.2_Missense_Mutation_p.A452V|RGS3_uc004bhz.2_Missense_Mutation_p.A473V|RGS3_uc004bia.2_Missense_Mutation_p.A244V	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	1131	RGS.				inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3						GAATACATCGCGATCCAGGCA	0.567000													27	51					0	0	1	0	0
TRIM32	22954	broad.mit.edu	37	9	119461244	119461244	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr9:119461244G>A	uc004bjx.2	+	2	1381	c.1223G>A	c.(1222-1224)CGC>CAC	p.R408H	ASTN2_uc004bjr.1_Intron|ASTN2_uc004bjs.1_Intron|ASTN2_uc004bjt.1_Intron|TRIM32_uc004bjw.2_Missense_Mutation_p.R408H	NM_001099679	NP_001093149	Q13049	TRI32_HUMAN	tripartite motif-containing 32	408					fat cell differentiation|innate immune response|negative regulation of apoptosis|negative regulation of fibroblast proliferation|positive regulation of cell cycle|positive regulation of cell growth|positive regulation of cell migration|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein catabolic process|positive regulation of proteolysis|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to tumor necrosis factor|response to UV	nucleus	myosin binding|protein self-association|RNA binding|Tat protein binding|transcription coactivator activity|translation initiation factor binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|kidney(1)	3						AAGGAAATCCGCCGCAGCCCC	0.517000									Bardet-Biedl_syndrome				84	101					0	0	1	0	0
ANAPC2	29882	broad.mit.edu	37	9	140079392	140079392	+	Missense_Mutation	SNP	T	C	C			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr9:140079392T>C	uc004clr.1	-	4	1094	c.1021A>G	c.(1021-1023)ATC>GTC	p.I341V	ANAPC2_uc004clq.1_Missense_Mutation_p.I200V	NM_013366	NP_037498	Q9UJX6	ANC2_HUMAN	anaphase-promoting complex subunit 2	341					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		AGCTCCTCGATGCGCAGGCTG	0.701000													6	43					0	0	1	0	0
GDPD2	54857	broad.mit.edu	37	X	69652495	69652495	+	Missense_Mutation	SNP	A	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chrX:69652495A>T	uc004dyh.2	+	14	1773	c.1522A>T	c.(1522-1524)ACC>TCC	p.T508S	GDPD2_uc010nky.1_3'UTR|GDPD2_uc011mpk.1_Missense_Mutation_p.T559S|GDPD2_uc011mpl.1_Missense_Mutation_p.T429S|GDPD2_uc011mpm.1_Missense_Mutation_p.T429S	NM_017711	NP_060181	Q9HCC8	GDPD2_HUMAN	osteoblast differentiation promoting factor	508	Helical; (Potential).				glycerol metabolic process|lipid metabolic process	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	glycerophosphodiester phosphodiesterase activity|glycerophosphoinositol inositolphosphodiesterase activity|metal ion binding			ovary(2)	2	Renal(35;0.156)					GCTTTTGTGGACCTTCCTCCT	0.488000													28	147					0	0	1	0	0
ATRX	546	broad.mit.edu	37	X	76939496	76939496	+	Nonsense_Mutation	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chrX:76939496G>A	uc004ecp.3	-	9	1484	c.1252C>T	c.(1252-1254)CGA>TGA	p.R418*	ATRX_uc004ecq.3_Nonsense_Mutation_p.R380*|ATRX_uc004eco.3_Nonsense_Mutation_p.R203*|ATRX_uc004ecr.2_Nonsense_Mutation_p.R379*|ATRX_uc010nlx.1_Nonsense_Mutation_p.R418*|ATRX_uc010nly.1_Nonsense_Mutation_p.R363*	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	418					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TCCATCGCTCGAAACTCGGAA	0.373000			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						184	169					0	0	1	0	0
NAP1L3	4675	broad.mit.edu	37	X	92927163	92927163	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chrX:92927163C>T	uc004efq.2	-	1	1446	c.1141G>A	c.(1141-1143)GCA>ACA	p.A381T	FAM133A_uc004efr.1_5'Flank	NM_004538	NP_004529	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	381					nucleosome assembly	chromatin assembly complex				ovary(1)|skin(1)	2						TCTGGTTTTGCCTTTATTATA	0.403000													6	40					0	0	1	0	0
ODZ1	10178	broad.mit.edu	37	X	123785888	123785888	+	Silent	SNP	G	A	A			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chrX:123785888G>A	uc004euj.2	-	8	1519	c.1455C>T	c.(1453-1455)AAC>AAT	p.N485N	ODZ1_uc011muj.1_Silent_p.N484N|ODZ1_uc010nqy.2_Silent_p.N485N	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	485	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TTAAGATCAGGTTCCGAGGGG	0.433000													8	55					0	0	1	0	0
NOTCH2	4853	broad.mit.edu	37	1	120612003	120612004	+	Frame_Shift_Del	DEL	GG	-	-			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr1:120612003_120612004delGG	uc001eik.2	-	1	273_274	c.17_18delCC	c.(16-18)CCCfs	p.P6fs	NOTCH2_uc001eil.2_Frame_Shift_Del_p.P6fs|NOTCH2_uc001eim.3_5'UTR	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	6					anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACAGCAGAGCGGGGCGCAGGGC	0.663			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				7	29	---	---	---	---					
PBRM1	55193	broad.mit.edu	37	3	52595944	52595944	+	Frame_Shift_Del	DEL	C	-	-			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr3:52595944delC	uc003des.2	-	25	4139	c.4127delG	c.(4126-4128)GGCfs	p.G1376fs	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Frame_Shift_Del_p.G1376fs|PBRM1_uc003der.2_Frame_Shift_Del_p.G1344fs|PBRM1_uc003det.2_Frame_Shift_Del_p.G1391fs|PBRM1_uc003deu.2_Frame_Shift_Del_p.G1391fs|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Frame_Shift_Del_p.G1376fs|PBRM1_uc010hmk.1_Frame_Shift_Del_p.G1351fs|PBRM1_uc003dey.2_Frame_Shift_Del_p.G1324fs|PBRM1_uc003dez.1_Frame_Shift_Del_p.G1375fs	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	1376					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		CCGTTTGGAGCCTTCCTTCTT	0.463			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								82	100	---	---	---	---					
RASA1	5921	broad.mit.edu	37	5	86627234	86627238	+	Frame_Shift_Del	DEL	TTATC	-	-			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr5:86627234_86627238delTTATC	uc003kiw.2	+	2	727_731	c.609_613delTTATC	c.(607-615)AGTTATCTTfs	p.S203fs	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Frame_Shift_Del_p.S26fs|RASA1_uc011ctv.1_Frame_Shift_Del_p.S36fs|RASA1_uc011ctw.1_Frame_Shift_Del_p.S37fs|RASA1_uc010jaw.2_Frame_Shift_Del_p.S26fs|RASA1_uc011ctu.1_Frame_Shift_Del_p.S203fs	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	203_205	SH2 1.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		AGTCTGGCAGTTATCTTATAAGAGA	0.415													14	69	---	---	---	---					
WRNIP1	56897	broad.mit.edu	37	6	2770460	2770463	+	Frame_Shift_Del	DEL	TGAT	-	-	rs144020288		TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr6:2770460_2770463delTGAT	uc003mtz.2	+	3	1312_1315	c.1121_1124delTGAT	c.(1120-1125)GTGATTfs	p.V374fs	WRNIP1_uc003mua.2_Frame_Shift_Del_p.V349fs	NM_020135	NP_064520	Q96S55	WRIP1_HUMAN	Werner helicase interacting protein isoform 1	374_375					DNA replication|DNA synthesis involved in DNA repair|regulation of DNA-dependent DNA replication initiation	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|DNA binding|metal ion binding|protein binding			ovary(1)|pancreas(1)	2	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				CGCTGTCGAGTGATTGTTCTTGAG	0.520													7	173	---	---	---	---					
TRERF1	55809	broad.mit.edu	37	6	42196333	42196333	+	Frame_Shift_Del	DEL	T	-	-			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr6:42196333delT	uc003osd.2	-	18	3916	c.3353delA	c.(3352-3354)AAGfs	p.K1118fs	TRERF1_uc011duq.1_Frame_Shift_Del_p.K1035fs|TRERF1_uc003osb.2_Frame_Shift_Del_p.K886fs|TRERF1_uc003osc.2_Frame_Shift_Del_p.K874fs|TRERF1_uc003ose.2_Frame_Shift_Del_p.K1138fs	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	1118	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTTCTGAGCCTTTTGCCTCTG	0.542													7	801	---	---	---	---					
DENND4C	55667	broad.mit.edu	37	9	19360274	19360274	+	Frame_Shift_Del	DEL	T	-	-			TCGA-E1-5307-01A-01D-1893-08	TCGA-E1-5307-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4b93592-7b90-4aab-9a5b-497b9d865c78	b9089424-6298-495f-afc9-604a38eddf01	g.chr9:19360274delT	uc003znq.2	+	24	4371	c.4338delT	c.(4336-4338)CCTfs	p.P1446fs	DENND4C_uc011lnc.1_Frame_Shift_Del_p.P776fs|DENND4C_uc011lnd.1_Frame_Shift_Del_p.P734fs|DENND4C_uc003znr.2_Frame_Shift_Del_p.P734fs|DENND4C_uc003zns.2_Frame_Shift_Del_p.P628fs	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	1446						integral to membrane				ovary(1)|skin(1)	2						ATCCTCCCCCTGTTTCTGTGC	0.353													28	115	---	---	---	---					
