Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PLEKHN1	84069	broad.mit.edu	37	1	907741	907741	+	Silent	SNP	C	T	T			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr1:907741C>T	uc001ace.2	+	9	1130	c.1095C>T	c.(1093-1095)CGC>CGT	p.R365R	PLEKHN1_uc001acd.2_Silent_p.R313R|PLEKHN1_uc001acf.2_Silent_p.R325R	NM_032129	NP_115505	Q494U1	PKHN1_HUMAN	pleckstrin homology domain containing, family N	365	PH 2.										0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.00095)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		TGTGCCTTCGCGCTGTCACCC	0.677000													5	18					0	0	0.021553	0	0
PKLR	5313	broad.mit.edu	37	1	155261708	155261708	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr1:155261708C>T	uc001fkb.3	-	10	1496	c.1457G>A	c.(1456-1458)CGG>CAG	p.R486Q	RAG1AP1_uc010pey.1_Intron|PKLR_uc001fka.3_Missense_Mutation_p.R455Q	NM_000298	NP_000289	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC isoform 1	486			R -> W (in PKRD; frequent mutation; no conformational change).		endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			skin(4)|ovary(1)	5	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	AGGTCGGTACCGAGACAGAAG	0.478000													16	69					0	0	0.049695	0	0
IGSF8	93185	broad.mit.edu	37	1	160064985	160064985	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr1:160064985C>T	uc001fva.2	-	2	161	c.116G>A	c.(115-117)CGC>CAC	p.R39H	IGSF8_uc001fuz.2_Missense_Mutation_p.R39H|IGSF8_uc009wtf.2_Missense_Mutation_p.R39H	NM_052868	NP_443100	Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	39	Ig-like C2-type 1.|Extracellular (Potential).				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding				0	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			GCCAGCCACGCGGTACAAGGG	0.617000													9	36					0	0	0.058154	0	0
ADCY10	55811	broad.mit.edu	37	1	167870982	167870982	+	Silent	SNP	C	T	T			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr1:167870982C>T	uc001ger.2	-	5	652	c.354G>A	c.(352-354)GTG>GTA	p.V118V	ADCY10_uc009wvk.2_Silent_p.V26V|ADCY10_uc010plj.1_Intron|ADCY10_uc009wvl.2_Silent_p.V117V|ADCY10_uc009wvm.2_Intron	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	118	Guanylate cyclase 1.				intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						ATTTAATTACCACTGTGATAA	0.498000													11	221					0	0	0.093190	0	0
CACNA1S	779	broad.mit.edu	37	1	201046152	201046152	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr1:201046152G>A	uc001gvv.2	-	12	1950	c.1723C>T	c.(1723-1725)CTC>TTC	p.L575F		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	575	II.|Helical; Name=S5 of repeat II; (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	ATGCCCAGGAGGGCGAAGATG	0.522000													7	129					0	0	0.047766	0	0
CENPF	1063	broad.mit.edu	37	1	214803886	214803886	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr1:214803886C>T	uc001hkm.2	+	9	1378	c.1204C>T	c.(1204-1206)CGT>TGT	p.R402C		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	402	Interaction with SNAP25 and required for localization to the cytoplasm (By similarity).|Potential.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		GGAGCTCTCCCGTCAACAGCG	0.537000													33	217					0	0	0.086207	0	0
FMN2	56776	broad.mit.edu	37	1	240371580	240371580	+	Silent	SNP	A	C	C			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr1:240371580A>C	uc010pyd.1	+	5	3693	c.3468A>C	c.(3466-3468)CCA>CCC	p.P1156P	FMN2_uc010pye.1_Silent_p.P1160P	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1156	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CTCCGCCCCCACTTCCCGGAG	0.706000													6	64					0	0	0.119110	0	0
OR2M3	127062	broad.mit.edu	37	1	248366731	248366731	+	Missense_Mutation	SNP	A	G	G			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr1:248366731A>G	uc010pzg.1	+	1	362	c.362A>G	c.(361-363)GAC>GGC	p.D121G		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	121	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ATGGCTTATGACCGCTACACT	0.463000													20	234					0	0	0.083992	0	0
TET1	80312	broad.mit.edu	37	10	70451205	70451205	+	Silent	SNP	C	T	T			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr10:70451205C>T	uc001jok.3	+	12	6550	c.6045C>T	c.(6043-6045)CAC>CAT	p.H2015H		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	2015					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						CACCTGCTCACGGCTCGGTTT	0.532000													82	138					0	0	0.048971	0	0
PTPRE	5791	broad.mit.edu	37	10	129877885	129877885	+	Missense_Mutation	SNP	G	T	T			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr10:129877885G>T	uc001lkb.2	+	20	2233	c.1954G>T	c.(1954-1956)GCC>TCC	p.A652S	PTPRE_uc009yat.2_Missense_Mutation_p.A663S|PTPRE_uc009yau.2_Missense_Mutation_p.A652S|PTPRE_uc001lkd.2_Missense_Mutation_p.A594S|PTPRE_uc010quq.1_Intron	NM_006504	NP_006495	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	652	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(1)	1		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				GCGAGTAAAAGCCGAGGGACT	0.458000													5	70					0.000602214	0.000638712	0.014758	1	0
MUC2	4583	broad.mit.edu	37	11	1086051	1086051	+	Missense_Mutation	SNP	C	T	T	rs72655318		TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr11:1086051C>T	uc001lsx.1	+	22	2918	c.2891C>T	c.(2890-2892)ACG>ATG	p.T964M		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	964	VWFD 3.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GAGTCCAGCACGGGCATCATC	0.632000													20	28					0	0	0.049695	0	0
ZNF143	7702	broad.mit.edu	37	11	9499964	9499964	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr11:9499964C>T	uc001mhr.2	+	6	519	c.401C>T	c.(400-402)GCG>GTG	p.A134V	ZNF143_uc009yfu.2_Missense_Mutation_p.A133V|ZNF143_uc010rby.1_Missense_Mutation_p.A103V	NM_003442	NP_003433	P52747	ZN143_HUMAN	zinc finger protein 143	134					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|zinc ion binding				0				all cancers(16;4.12e-09)|Epithelial(150;2.29e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0212)		GCATTACAGGCGGTTCAGCTG	0.433000													64	89					0	0	0.048971	0	0
AGBL2	79841	broad.mit.edu	37	11	47726176	47726176	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr11:47726176T>C	uc001ngg.2	-	6	605	c.505A>G	c.(505-507)ATT>GTT	p.I169V	AGBL2_uc010rhq.1_Missense_Mutation_p.I131V|AGBL2_uc001ngh.1_Missense_Mutation_p.I113V	NM_024783	NP_079059	Q5U5Z8	CBPC2_HUMAN	carboxypeptidase 2, cytosolic	169					proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2						GTAGACAAAATGGAAAAGAGC	0.428000													15	61					0	0	0.049695	0	0
RTN3	10313	broad.mit.edu	37	11	63487064	63487064	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr11:63487064G>A	uc001nxq.2	+	3	1277	c.1090G>A	c.(1090-1092)GGA>AGA	p.G364R	RTN3_uc001nxo.2_Intron|RTN3_uc001nxm.2_Intron|RTN3_uc001nxn.2_Missense_Mutation_p.G345R|RTN3_uc001nxp.2_Intron|RTN3_uc009yov.2_Missense_Mutation_p.G252R|RTN3_uc010rmt.1_Intron|RTN3_uc010rmu.1_Intron	NM_201428	NP_958831	O95197	RTN3_HUMAN	reticulon 3 isoform b	364					apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				ovary(1)	1						AAAAACTACAGGACTTGACAT	0.373000													3	57					0	0	0.115264	0	0
RNF121	55298	broad.mit.edu	37	11	71671806	71671806	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr11:71671806G>A	uc001ora.2	+	3	452	c.112G>A	c.(112-114)GCA>ACA	p.A38T	RNF121_uc001ord.2_5'UTR|RNF121_uc001orb.2_Missense_Mutation_p.A6T|RNF121_uc009yst.2_Missense_Mutation_p.A6T	NM_018320	NP_060790	Q9H920	RN121_HUMAN	ring finger protein 121	38						integral to membrane	zinc ion binding				0						GGTCGAGCACGCACGCATGCA	0.542000													4	94					0	0	0.014758	0	0
CAPZA3	93661	broad.mit.edu	37	12	18891209	18891209	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr12:18891209C>T	uc001rdy.2	+	1	165	c.7C>T	c.(7-9)CTT>TTT	p.L3F	PLCZ1_uc001rdv.3_5'Flank|PLCZ1_uc001rdw.3_5'Flank|PLCZ1_uc010sid.1_5'Flank	NM_033328	NP_201585	Q96KX2	CAZA3_HUMAN	capping protein alpha 3	3					actin cytoskeleton organization|actin filament capping	F-actin capping protein complex	actin binding			ovary(1)|central_nervous_system(1)	2	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)	Hepatocellular(102;0.194)				AAACATGACACTTAGCGTGCT	0.438000													5	85					0	0	0.021553	0	0
KIF21A	55605	broad.mit.edu	37	12	39763628	39763628	+	Missense_Mutation	SNP	A	C	C			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr12:39763628A>C	uc001rly.2	-	3	499	c.353T>G	c.(352-354)GTT>GGT	p.V118G	KIF21A_uc001rlx.2_Missense_Mutation_p.V118G|KIF21A_uc001rlz.2_Missense_Mutation_p.V118G|KIF21A_uc010skl.1_Missense_Mutation_p.V118G|KIF21A_uc001rma.1_Missense_Mutation_p.V118G	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	118	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				AAGGTGTTTAACAGCTCGAGA	0.348000													10	38					0	0	0.058154	0	0
MLL2	8085	broad.mit.edu	37	12	49431213	49431213	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr12:49431213G>A	uc001rta.3	-	34	9926	c.9926C>T	c.(9925-9927)TCC>TTC	p.S3309F		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	3309	Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CTGCTGTTGGGACCCAGCCAA	0.557000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			9	5					0	0	0.093190	0	0
SLITRK5	26050	broad.mit.edu	37	13	88329160	88329160	+	Missense_Mutation	SNP	A	G	G			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr13:88329160A>G	uc001vln.2	+	2	1736	c.1517A>G	c.(1516-1518)AAC>AGC	p.N506S	SLITRK5_uc010tic.1_Missense_Mutation_p.N265S	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	506	Extracellular (Potential).|LRR 11.					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CCGGTCCCAAACCTCCAGCTG	0.532000													31	56					0	0	0.111260	0	0
BMP4	652	broad.mit.edu	37	14	54416985	54416985	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr14:54416985C>T	uc001xal.3	-	3	1179	c.992G>A	c.(991-993)GGC>GAC	p.G331D	BMP4_uc010aoh.2_Missense_Mutation_p.G331D|BMP4_uc001xao.3_Missense_Mutation_p.G331D|BMP4_uc001xan.3_Missense_Mutation_p.G331D	NM_130851	NP_570912	P12644	BMP4_HUMAN	bone morphogenetic protein 4 preproprotein	331					activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity				0						GGCCTGGTAGCCTGGTGGGGC	0.572000													9	59					0	0	0.058154	0	0
CACNA1H	8912	broad.mit.edu	37	16	1251754	1251754	+	Missense_Mutation	SNP	A	G	G			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr16:1251754A>G	uc002cks.2	+	9	1552	c.1304A>G	c.(1303-1305)GAG>GGG	p.E435G	CACNA1H_uc002ckt.2_Missense_Mutation_p.E435G	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	435	Cytoplasmic (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CTGATGCGGGAGCAGCGGGCA	0.612000													8	14					0	0	0.038147	0	0
HPR	3250	broad.mit.edu	37	16	72110614	72110614	+	Silent	SNP	A	G	G			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr16:72110614A>G	uc002fby.2	+	5	711	c.681A>G	c.(679-681)GGA>GGG	p.G227G	TXNL4B_uc010cgl.2_Intron	NM_020995	NP_066275	P00739	HPTR_HUMAN	haptoglobin-related protein precursor	227	Peptidase S1.				proteolysis	spherical high-density lipoprotein particle	hemoglobin binding|serine-type endopeptidase activity			central_nervous_system(1)	1		Ovarian(137;0.125)				CTGGCTGGGGACAAAGTGACA	0.463000													7	133					0	0	0.047766	0	0
TP53	7157	broad.mit.edu	37	17	7577121	7577121	+	Missense_Mutation	SNP	G	A	A	rs121913343		TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542000	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			24	3					0	0	0.099896	0	0
FLJ40504	284085	broad.mit.edu	37	17	26604406	26604406	+	Silent	SNP	C	T	T			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr17:26604406C>T	uc002has.3	-	3	165	c.69G>A	c.(67-69)CCG>CCA	p.P23P		NM_173624	NP_775895			SubName: Full=Putative uncharacterized protein FLJ40504; SubName: Full=cDNA FLJ40504 fis, clone TESTI2045509, highly similar to KERATIN, TYPE I CYTOSKELETAL 18;												0	all_lung(13;0.000238)|Lung NSC(42;0.000789)			UCEC - Uterine corpus endometrioid carcinoma (53;0.155)		CAGGTTTTGACGGCCAATTTT	0.438000													6	72					0	0	0.038147	0	0
MUC16	94025	broad.mit.edu	37	19	9057582	9057582	+	Missense_Mutation	SNP	G	C	C			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr19:9057582G>C	uc002mkp.2	-	3	30068	c.29864C>G	c.(29863-29865)ACC>AGC	p.T9955S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9957	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTGGTGATGGTCATTTGTGT	0.498000													47	254					0	0	0.048971	0	0
MUC16	94025	broad.mit.edu	37	19	9068570	9068570	+	Silent	SNP	T	A	A			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr19:9068570T>A	uc002mkp.2	-	3	19080	c.18876A>T	c.(18874-18876)ACA>ACT	p.T6292T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6294	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCATTGTGTGTGTATCTGTGG	0.453000													22	129					0	0	0.091800	0	0
ANO8	57719	broad.mit.edu	37	19	17438523	17438523	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr19:17438523C>T	uc002ngf.2	-	14	2552	c.2393G>A	c.(2392-2394)CGC>CAC	p.R798H	ANO8_uc010eap.2_RNA	NM_020959	NP_066010	Q9HCE9	ANO8_HUMAN	anoctamin 8	798	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(3)	3						GCTTTCCACGCGCTGGCCGAA	0.682000													21	36					0	0	0.045705	0	0
FFAR1	2864	broad.mit.edu	37	19	35842815	35842815	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr19:35842815T>C	uc002nzc.2	+	1	371	c.361T>C	c.(361-363)TGC>CGC	p.C121R		NM_005303	NP_005294	O14842	FFAR1_HUMAN	free fatty acid receptor 1	121	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity|lipid binding			central_nervous_system(1)	1	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;4.58e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.67e-19)|all cancers(14;2.01e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)		Icosapent(DB00159)	CCGGAGGCCGTGCTATTCCTG	0.677000													10	43					0	0	0.093190	0	0
GRIN2D	2906	broad.mit.edu	37	19	48945567	48945567	+	Missense_Mutation	SNP	C	A	A			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr19:48945567C>A	uc002pjc.3	+	12	2689	c.2601C>A	c.(2599-2601)CAC>CAA	p.H867Q	GRIN2D_uc010elx.2_Missense_Mutation_p.H102Q	NM_000836	NP_000827	O15399	NMDE4_HUMAN	N-methyl-D-aspartate receptor subunit 2D	867	Cytoplasmic (Potential).					cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			ovary(3)|breast(3)	6		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	CCTGGGAGCACCTGGTGTACT	0.587000													48	39					1.83081e-24	2.00245e-24	0.048971	1	0
PTPRH	5794	broad.mit.edu	37	19	55693430	55693430	+	Missense_Mutation	SNP	A	T	T			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr19:55693430A>T	uc002qjq.2	-	19	3225	c.3152T>A	c.(3151-3153)TTT>TAT	p.F1051Y	PTPRH_uc010esv.2_Missense_Mutation_p.F873Y|SYT5_uc002qjm.1_5'Flank|SYT5_uc002qjp.2_5'Flank|SYT5_uc002qjn.1_5'Flank|SYT5_uc002qjo.1_5'Flank	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	1051	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		CTTCCTTACAAAGCTGAAGGG	0.622000													32	76					0	0	0.069456	0	0
NLRP9	338321	broad.mit.edu	37	19	56244181	56244181	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr19:56244181G>A	uc002qly.2	-	2	1044	c.1016C>T	c.(1015-1017)ACG>ATG	p.T339M		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	339	NACHT.					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		CAACCAGCACGTAAAGGGATT	0.413000													36	29					0	0	0.086207	0	0
HEATR5B	54497	broad.mit.edu	37	2	37215881	37215881	+	Missense_Mutation	SNP	C	T	T	rs77915442		TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr2:37215881C>T	uc002rpp.1	-	35	5915	c.5819G>A	c.(5818-5820)AGA>AAA	p.R1940K	HEATR5B_uc002rpo.1_Missense_Mutation_p.R252K|HEATR5B_uc010ezy.1_Missense_Mutation_p.R435K	NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1940							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				TGGTCTGTTTCTTTCAACAGC	0.393000													7	79					0	0	0.058154	0	0
DHX57	90957	broad.mit.edu	37	2	39095413	39095413	+	Silent	SNP	A	T	T			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr2:39095413A>T	uc002rrf.2	-	2	234	c.135T>A	c.(133-135)GGT>GGA	p.G45G	DHX57_uc002rre.2_5'Flank|DHX57_uc002rrg.2_Silent_p.G45G	NM_198963	NP_945314	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	45	Gly-rich.						ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		all_hematologic(82;0.248)				cgccacctccaccaccaccac	0.383000													3	82					0	0	0.115264	0	0
LRP1B	53353	broad.mit.edu	37	2	141739804	141739804	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr2:141739804G>A	uc002tvj.1	-	18	3784	c.2812C>T	c.(2812-2814)CGT>TGT	p.R938C	LRP1B_uc010fnl.1_Missense_Mutation_p.R120C	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	938	Extracellular (Potential).|LDL-receptor class A 5.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GGAATGCAACGCCCATTTCCG	0.423000										TSP Lung(27;0.18)			16	85					0	0	0.038395	0	0
ACVR2A	92	broad.mit.edu	37	2	148653873	148653873	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr2:148653873C>T	uc002twg.2	+	3	328	c.59C>T	c.(58-60)GCT>GTT	p.A20V	ACVR2A_uc010zbn.1_Intron|ACVR2A_uc002twh.2_Missense_Mutation_p.A20V	NM_001616	NP_001607	P27037	AVR2A_HUMAN	activin A receptor, type IIA precursor	20	Extracellular (Potential).				activin receptor signaling pathway|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of erythrocyte differentiation|positive regulation of osteoblast differentiation|positive regulation of protein phosphorylation	cytoplasm|inhibin-betaglycan-ActRII complex|integral to plasma membrane	ATP binding|coreceptor activity|inhibin beta-A binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			stomach(8)|large_intestine(2)|lung(1)|breast(1)|kidney(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0969)		CTTATAGGTGCTATACTTGGT	0.333000													13	64					0	0	0.119110	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								36	48					0	0	0.104719	0	0
KLHL30	377007	broad.mit.edu	37	2	239050040	239050040	+	Silent	SNP	G	A	A			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr2:239050040G>A	uc002vxr.1	+	1	624	c.591G>A	c.(589-591)CTG>CTA	p.L197L		NM_198582	NP_940984	Q0D2K2	KLH30_HUMAN	kelch-like 30	215	BACK.										0		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		CCGCCCACCTGCCCGAGCTGC	0.706000													3	8					0	0	0.115264	0	0
SRMS	6725	broad.mit.edu	37	20	62178604	62178604	+	Silent	SNP	A	G	G			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr20:62178604A>G	uc002yfi.1	-	1	254	c.213T>C	c.(211-213)AGT>AGC	p.S71S		NM_080823	NP_543013	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory	71	SH3.						ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(1)|lung(1)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			CGCGGCGGACACTCAGCTCCC	0.697000													7	7					0	0	0.038147	0	0
TIMP3	7078	broad.mit.edu	37	22	33255348	33255348	+	Missense_Mutation	SNP	A	G	G			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr22:33255348A>G	uc003anb.2	+	5	1806	c.620A>G	c.(619-621)AAT>AGT	p.N207S	SYN3_uc003amx.2_Intron|SYN3_uc003amy.2_Intron|SYN3_uc003amz.2_Intron	NM_000362	NP_000353	P35625	TIMP3_HUMAN	tissue inhibitor of metalloproteinase 3	207					negative regulation of membrane protein ectodomain proteolysis|visual perception		metal ion binding|metalloendopeptidase inhibitor activity|protein binding			lung(1)	1						AGCATCATCAATGCCACAGAC	0.592000													3	24					0	0	0.009096	0	0
SMARCC1	6599	broad.mit.edu	37	3	47719787	47719787	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr3:47719787C>T	uc003crq.2	-	16	1590	c.1472G>A	c.(1471-1473)CGA>CAA	p.R491Q	SMARCC1_uc011bbc.1_RNA|SMARCC1_uc011bbd.1_Missense_Mutation_p.R382Q	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	491	SWIRM.				chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		CATAAAATTTCGATATGCCAA	0.388000													8	151					0	0	0.069234	0	0
ZBTB49	166793	broad.mit.edu	37	4	4304568	4304568	+	Silent	SNP	G	A	A			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr4:4304568G>A	uc003ghu.2	+	3	1180	c.1005G>A	c.(1003-1005)AAG>AAA	p.K335K	ZBTB49_uc003ghv.2_5'UTR|ZBTB49_uc010icy.2_RNA|ZBTB49_uc010icz.2_Silent_p.K35K	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	zinc finger protein 509	335					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						GTTTGACAAAGAGGTTGGAAT	0.398000													21	30					0	0	0.076483	0	0
GUF1	60558	broad.mit.edu	37	4	44693681	44693681	+	Splice_Site	SNP	A	G	G			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr4:44693681A>G	uc003gww.3	+	13	1687	c.1480_splice	c.e13-2	p.A494_splice		NM_021927	NP_068746	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog						translation	mitochondrial inner membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)	1						TTCCCTTTTTAGGCTCGAAGA	0.299000													8	128					0	0	0.093190	0	0
AREG	374	broad.mit.edu	37	4	75312475	75312475	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr4:75312475T>C	uc011cbl.1	+	2	496	c.286T>C	c.(286-288)TAT>CAT	p.Y96H		NM_001657	NP_001648	P15514	AREG_HUMAN	amphiregulin preproprotein	96					cell proliferation|cell-cell signaling|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|positive regulation of DNA replication	cell surface|extracellular space|integral to membrane	cytokine activity|growth factor activity				0			Lung(101;0.196)			AATACCTGGCTATATTGTCGA	0.443000													5	131					0	0	0.029380	0	0
FHDC1	85462	broad.mit.edu	37	4	153897446	153897446	+	Missense_Mutation	SNP	G	C	C			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr4:153897446G>C	uc003inf.2	+	11	3078	c.3003G>C	c.(3001-3003)AAG>AAC	p.K1001N		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	1001					actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					AGGAAAATAAGACCTGCCGCG	0.632000													4	36					0	0	0.014758	0	0
NPY1R	4886	broad.mit.edu	37	4	164246852	164246852	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr4:164246852T>C	uc003iqm.1	-	3	1024	c.758A>G	c.(757-759)TAC>TGC	p.Y253C	NPY1R_uc011cjj.1_Missense_Mutation_p.Y10C	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	253	Cytoplasmic (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				ACTGGACCTGTACTTATTGTC	0.368000													11	30					0	0	0.024245	0	0
FAM169A	26049	broad.mit.edu	37	5	74130350	74130350	+	Silent	SNP	T	G	G			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr5:74130350T>G	uc003kdm.2	-	5	434	c.391A>C	c.(391-393)AGA>CGA	p.R131R	FAM169A_uc010izm.2_Silent_p.R131R|FAM169A_uc003kdl.2_Intron	NM_015566	NP_056381	Q9Y6X4	F169A_HUMAN	hypothetical protein LOC26049	131											0						ATCTCATTTCTCTCCATTTCC	0.418000													3	50					0	0	0.115264	0	0
PCDHA7	56141	broad.mit.edu	37	5	140214183	140214183	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr5:140214183G>A	uc003lhq.2	+	1	215	c.215G>A	c.(214-216)GGG>GAG	p.G72E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.G72E	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	72	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAATTCCGTGGGGATCTTCTG	0.617000													8	273					0	0	0.047766	0	0
HAVCR2	84868	broad.mit.edu	37	5	156535952	156535952	+	Silent	SNP	G	A	A			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr5:156535952G>A	uc003lwk.1	-	1	187	c.43C>T	c.(43-45)CTG>TTG	p.L15L	HAVCR2_uc003lwl.2_Silent_p.L15L	NM_032782	NP_116171	Q8TDQ0	HAVR2_HUMAN	T cell immunoglobulin mucin 3 precursor	15						integral to membrane					0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGTAGTAGCAGCAGCAGCAGC	0.299000													3	80					0	0	0.009096	0	0
C5orf25	375484	broad.mit.edu	37	5	175716891	175716891	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr5:175716891C>T	uc003mds.3	+	4	714	c.307C>T	c.(307-309)CGG>TGG	p.R103W	C5orf25_uc003mdt.3_Intron|C5orf25_uc003mdr.3_Intron|C5orf25_uc011dfk.1_Missense_Mutation_p.R122W|uc003mdu.1_Missense_Mutation_p.R14W			Q8NDZ2	CE025_HUMAN	RecName: Full=Uncharacterized protein C5orf25;	103											0	all_cancers(89;0.00381)|Renal(175;0.000269)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.119)		GCCTACAGCACGGAGAATCAT	0.522000													13	86					0	0	0.028581	0	0
VARS	7407	broad.mit.edu	37	6	31747885	31747885	+	Silent	SNP	G	A	A			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr6:31747885G>A	uc003nxe.2	-	26	3394	c.2971C>T	c.(2971-2973)CTG>TTG	p.L991L	C6orf27_uc011dog.1_5'Flank|C6orf27_uc003nxd.2_5'Flank|C6orf27_uc011doh.1_5'Flank|VARS_uc003nxf.1_5'UTR	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	991					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	GCCTCTGTCAGGCGGCTGCGG	0.647000													10	57					0	0	0.080935	0	0
NOTCH4	4855	broad.mit.edu	37	6	32188018	32188018	+	Nonsense_Mutation	SNP	G	T	T			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr6:32188018G>T	uc003obb.2	-	7	1342	c.1203C>A	c.(1201-1203)TGC>TGA	p.C401*	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc003obc.2_Nonsense_Mutation_p.C401*	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	401	EGF-like 10.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						CATCCCCATGGCACGGCTGGC	0.622000													13	76					8.60227e-14	9.26399e-14	0.028581	1	0
PKHD1	5314	broad.mit.edu	37	6	51799071	51799071	+	Silent	SNP	G	A	A			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr6:51799071G>A	uc003pah.1	-	37	6234	c.5958C>T	c.(5956-5958)CAC>CAT	p.H1986H	PKHD1_uc010jzn.1_Silent_p.H11H|PKHD1_uc003pai.2_Silent_p.H1986H	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1986	Extracellular (Potential).|G8 1.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CAAGGATGGCGTGTGCCCTGA	0.537000											OREG0017491	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	122					0	0	0.021553	0	0
NCOA7	135112	broad.mit.edu	37	6	126210341	126210341	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr6:126210341T>C	uc010kes.2	+	11	1590	c.1141T>C	c.(1141-1143)TCC>CCC	p.S381P	NCOA7_uc003qae.3_Missense_Mutation_p.S381P|NCOA7_uc003qah.2_Missense_Mutation_p.S370P|NCOA7_uc003qai.2_Missense_Mutation_p.S381P|NCOA7_uc010ket.2_Missense_Mutation_p.S266P	NM_181782	NP_861447	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7 isoform 1	381					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		TAGGGAGACATCCCATGGTTC	0.458000													7	31					0	0	0.058154	0	0
TIAM2	26230	broad.mit.edu	37	6	155458449	155458449	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr6:155458449T>C	uc003qqb.2	+	7	2606	c.1333T>C	c.(1333-1335)TCC>CCC	p.S445P	TIAM2_uc003qqe.2_Missense_Mutation_p.S445P|TIAM2_uc010kjj.2_5'UTR	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	445					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		GAGAAGTGAATCCACACATGC	0.498000													4	124					0	0	0.021553	0	0
CDC14C	168448	broad.mit.edu	37	7	48965555	48965555	+	Silent	SNP	T	C	C			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr7:48965555T>C	uc010kyv.1	+	1	1399	c.1287T>C	c.(1285-1287)TGT>TGC	p.C429C		NR_003595				SubName: Full=Putative uncharacterized protein MGC26484;												0						TTACACTGTGTAGTGTTGTCA	0.458000													5	5					0	0	0.021553	0	0
ZNF479	90827	broad.mit.edu	37	7	57187809	57187809	+	Missense_Mutation	SNP	T	G	G			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr7:57187809T>G	uc010kzo.2	-	5	1584	c.1313A>C	c.(1312-1314)AAA>ACA	p.K438T		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	438	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TTCTTCACATTTGTAGGGTCT	0.453000													9	94					0	0	0.058154	0	0
NRCAM	4897	broad.mit.edu	37	7	107823139	107823139	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr7:107823139G>A	uc003vfb.2	-	23	3001	c.2530C>T	c.(2530-2532)CTC>TTC	p.L844F	NRCAM_uc003vfc.2_Missense_Mutation_p.L828F|NRCAM_uc011kmk.1_Missense_Mutation_p.L839F|NRCAM_uc003vfd.2_Missense_Mutation_p.L820F|NRCAM_uc003vfe.2_Missense_Mutation_p.L820F	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	844	Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						CATCACTTACGGTCTTCTCCA	0.522000													19	35					0	0	0.076483	0	0
CCDC136	64753	broad.mit.edu	37	7	128432468	128432468	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr7:128432468G>A	uc003vnv.1	+	1	370	c.3G>A	c.(1-3)ATG>ATA	p.M1I	CCDC136_uc003vnu.1_Missense_Mutation_p.M51I|CCDC136_uc003vnw.1_Missense_Mutation_p.M1I	NM_022742	NP_073579	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	1						integral to membrane	protein binding			ovary(2)	2						GACGGGGGATGCAAGCTATGG	0.453000													15	62					0	0	0.033300	0	0
FAM47C	442444	broad.mit.edu	37	X	37028134	37028134	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chrX:37028134C>T	uc004ddl.1	+	1	1665	c.1651C>T	c.(1651-1653)CCT>TCT	p.P551S		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	551										ovary(3)	3						CCCAGAGCCTCCTGAGACTGG	0.617000													3	63					0	0	0.009096	0	0
VPS37C	55048	broad.mit.edu	37	11	60899568	60899569	+	Frame_Shift_Del	DEL	CC	-	-			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr11:60899568_60899569delCC	uc001nqv.1	-	5	851_852	c.791_792delGG	c.(790-792)AGGfs	p.R264fs		NM_017966	NP_060436	A5D8V6	VP37C_HUMAN	vacuolar protein sorting 37C	264	Pro-rich.				cellular membrane organization|endosome transport|protein transport	late endosome membrane					0						GTGGCATGCTCCTCTGTGGGGA	0.693													2	4	---	---	---	---					
DGKH	160851	broad.mit.edu	37	13	42783569	42783569	+	Frame_Shift_Del	DEL	A	-	-			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr13:42783569delA	uc001uyl.1	+	23	2839	c.2818delA	c.(2818-2820)AAAfs	p.K940fs	DGKH_uc010tfh.1_Frame_Shift_Del_p.K940fs|DGKH_uc001uym.1_Frame_Shift_Del_p.K940fs|DGKH_uc010tfi.1_Frame_Shift_Del_p.K695fs|DGKH_uc010tfj.1_Frame_Shift_Del_p.K795fs|DGKH_uc001uyn.1_RNA|DGKH_uc001uyo.1_Frame_Shift_Del_p.K795fs|DGKH_uc001uyp.2_RNA	NM_178009	NP_821077	Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta isoform 2	940					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		AATTGTGCACAAAAACAGAGC	0.378													40	50	---	---	---	---					
ZIC5	85416	broad.mit.edu	37	13	100623411	100623413	+	In_Frame_Del	DEL	AGG	-	-			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr13:100623411_100623413delAGG	uc001vom.1	-	1	766_768	c.517_519delCCT	c.(517-519)CCTdel	p.P173del		NM_033132	NP_149123	Q96T25	ZIC5_HUMAN	zinc finger protein of the cerebellum 5	173	Pro-rich.				cell differentiation	nucleus	DNA binding|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CCGAGAGGGCaggaggaggagga	0.542													2	4	---	---	---	---					
ZFHX3	463	broad.mit.edu	37	16	72994030	72994031	+	Frame_Shift_Ins	INS	-	TCACAGCC	TCACAGCC	rs12922701		TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chr16:72994030_72994031insTCACAGCC	uc002fck.2	-	2	687_688	c.14_15insGGCTGTGA	c.(13-15)GACfs	p.D5fs	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	5					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				CGACGGGCGAGTCACAGCCTTC	0.485													21	168	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76855040	76855046	+	Frame_Shift_Del	DEL	TTTCTTC	-	-			TCGA-FG-7636-01A-11D-2086-08	TCGA-FG-7636-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	69986481-decd-42b7-9286-6850f1956764	667c8d9c-4ed8-4f36-99fb-84a6df7b0e5e	g.chrX:76855040_76855046delTTTCTTC	uc004ecp.3	-	25	6022_6028	c.5790_5796delGAAGAAA	c.(5788-5796)AAGAAGAAAfs	p.K1930fs	ATRX_uc004ecq.3_Frame_Shift_Del_p.K1892fs|ATRX_uc004eco.3_Frame_Shift_Del_p.K1715fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1930_1932	Poly-Lys.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTTTCCCTTTTTTCTTCTTTCTaaaaa	0.324			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						63	73	---	---	---	---					
