Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MST1P2	11209	broad.mit.edu	37	1	16974243	16974243	+	RNA	SNP	G	C	C	rs142213352	by1000genomes	TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr1:16974243G>C	uc009vow.2	+	5		c.1053G>C			MST1P2_uc010ocg.1_RNA|MST1P2_uc010och.1_Intron|MST1P2_uc010oci.1_RNA|MST1P2_uc001azk.2_Intron|MST1P2_uc001azl.3_RNA|MST1P2_uc009vox.2_Intron|MST1P2_uc001azm.3_Intron					Homo sapiens cDNA FLJ53774 complete cds, moderately similar to Hepatocyte growth factor-like protein precursor.												0						GATCTCAGCTGTCGCTCGGGG	0.652000													3	22					0	0	0.004672	0	0
ARID1A	8289	broad.mit.edu	37	1	27100381	27100381	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr1:27100381C>T	uc001bmv.1	+	17	4466	c.4093C>T	c.(4093-4095)CAA>TAA	p.Q1365*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q1364*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q1365*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q982*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.Q211*|ARID1A_uc009vsm.1_5'UTR|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1365	Gln-rich.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GTATCAACAGCAACAGCAGGT	0.498000			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								52	99					0	0	0.014410	0	0
CCDC76	54482	broad.mit.edu	37	1	100613719	100613719	+	Missense_Mutation	SNP	T	G	G			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr1:100613719T>G	uc001dsv.2	+	10	1106	c.1087T>G	c.(1087-1089)TAT>GAT	p.Y363D	CCDC76_uc010ouf.1_RNA|CCDC76_uc009wea.2_Intron	NM_019083	NP_061956	Q9NUP7	TRM13_HUMAN	coiled-coil domain containing 76	363					tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)		GGAATTCCATTATTTCCAGCG	0.428000													34	9					0	0	0.012213	0	0
FLG2	388698	broad.mit.edu	37	1	152328282	152328282	+	Silent	SNP	T	C	C			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr1:152328282T>C	uc001ezw.3	-	3	2053	c.1980A>G	c.(1978-1980)TCA>TCG	p.S660S	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	660	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCTGAGCCTGATCCATATT	0.488000													5	419					0	0	0.001855	0	0
SYT2	127833	broad.mit.edu	37	1	202568369	202568369	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr1:202568369C>T	uc001gye.2	-	8	1223	c.1030G>A	c.(1030-1032)GAG>AAG	p.E344K	SYT2_uc010pqb.1_Missense_Mutation_p.E344K|SYT2_uc009xaf.2_Missense_Mutation_p.E174K	NM_001136504	NP_001129976	Q8N9I0	SYT2_HUMAN	synaptotagmin II	344	Phospholipid binding (By similarity).|C2 2.|Cytoplasmic (Potential).				neurotransmitter secretion	cell junction|chromaffin granule membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	protein binding|transporter activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.169)		Botulinum Toxin Type B(DB00042)	AAGGGGATCTCAAAGCTGAAG	0.522000													5	189					0	0	0.001168	0	0
HEATR1	55127	broad.mit.edu	37	1	236738051	236738051	+	Silent	SNP	C	T	T	rs142628625	byFrequency	TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr1:236738051C>T	uc001hyd.1	-	23	3362	c.3237G>A	c.(3235-3237)CCG>CCA	p.P1079P	HEATR1_uc009xgh.1_Intron	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	1079					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			CTAGACTCTTCGGATCCTCAT	0.423000													27	41					0	0	0.007291	0	0
KIF26B	55083	broad.mit.edu	37	1	245530297	245530297	+	Silent	SNP	C	T	T			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr1:245530297C>T	uc001ibf.1	+	3	1067	c.627C>T	c.(625-627)GCC>GCT	p.A209A	KIF26B_uc010pyq.1_Silent_p.A209A|KIF26B_uc010pyr.1_Silent_p.A9A	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	209					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			AGCAGGCAGCCGGCAGTGAGC	0.657000													4	35					0	0	0.009096	0	0
OR2G6	391211	broad.mit.edu	37	1	248685220	248685220	+	Silent	SNP	C	T	T			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr1:248685220C>T	uc001ien.1	+	1	273	c.273C>T	c.(271-273)ACC>ACT	p.T91T		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	91	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AAGACAAAACCATGAGCTACG	0.517000													55	86					0	0	0.014410	0	0
ANKRD26	22852	broad.mit.edu	37	10	27381396	27381396	+	Missense_Mutation	SNP	G	C	C			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr10:27381396G>C	uc001ith.2	-	4	749	c.577C>G	c.(577-579)CAA>GAA	p.Q193E	ANKRD26_uc009xku.1_Missense_Mutation_p.Q193E	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	193	ANK 5.					centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						TCCACCATTTGCTGCTTTTTT	0.323000													6	23					0	0	0.003080	0	0
TLL2	7093	broad.mit.edu	37	10	98144479	98144479	+	Missense_Mutation	SNP	C	T	T	rs141438733		TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr10:98144479C>T	uc001kml.1	-	16	2285	c.2059G>A	c.(2059-2061)GAC>AAC	p.D687N		NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	687	CUB 3.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		AGCTTGGCGTCGGGGGACAGG	0.622000													59	100					0	0	0.014410	0	0
MGEA5	10724	broad.mit.edu	37	10	103577687	103577687	+	Silent	SNP	C	A	A			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr10:103577687C>A	uc001ktv.2	-	1	536	c.93G>T	c.(91-93)CCG>CCT	p.P31P	MGEA5_uc010qqe.1_Silent_p.P31P|MGEA5_uc009xws.2_Silent_p.P31P|MGEA5_uc001ktw.2_Silent_p.P31P|MGEA5_uc009xwt.2_5'UTR|MGEA5_uc010qqf.1_RNA	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	31					glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		GAGCTGCCGGCGGCTCCAGCG	0.726000													8	7					0.000157383	0.000171956	0.003080	1	0
CUEDC2	79004	broad.mit.edu	37	10	104184887	104184887	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr10:104184887G>A	uc001kvn.2	-	2	210	c.59C>T	c.(58-60)CCG>CTG	p.P20L	CUEDC2_uc001kvm.2_5'Flank	NM_024040	NP_076945	Q9H467	CUED2_HUMAN	CUE domain containing 2	20						cytoplasm|nucleus	protein binding				0		Colorectal(252;0.122)		Epithelial(162;9.17e-09)|all cancers(201;2.16e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		GTCGGCCTCCGGGAGGTGTGT	0.602000													6	74					0	0	0.001984	0	0
MUC2	4583	broad.mit.edu	37	11	1087506	1087506	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr11:1087506G>A	uc001lsx.1	+	24	3284	c.3257G>A	c.(3256-3258)GGG>GAG	p.G1086E		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	1086						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GACACGGGTGGGGACTGTGAG	0.652000													15	26					0	0	0.002450	0	0
OR5D18	219438	broad.mit.edu	37	11	55587473	55587473	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr11:55587473G>A	uc010rin.1	+	1	368	c.368G>A	c.(367-369)CGC>CAC	p.R123H		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	123	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				GCCTATGACCGCTTCGTGGCC	0.458000													39	124					0	0	0.007835	0	0
AHNAK	79026	broad.mit.edu	37	11	62296070	62296070	+	Missense_Mutation	SNP	A	G	G			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr11:62296070A>G	uc001ntl.2	-	5	6119	c.5819T>C	c.(5818-5820)GTG>GCG	p.V1940A	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1940					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CGACACATCCACATCCCCTTT	0.502000													6	290					0	0	0.001168	0	0
WDR74	54663	broad.mit.edu	37	11	62606628	62606628	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr11:62606628G>A	uc001nvm.1	-	4	419	c.251C>T	c.(250-252)CCG>CTG	p.P84L	WDR74_uc001nvk.1_Missense_Mutation_p.P27L|WDR74_uc001nvl.1_Missense_Mutation_p.P84L|WDR74_uc001nvn.1_Missense_Mutation_p.P136L|WDR74_uc009yoi.1_Missense_Mutation_p.P84L|WDR74_uc010rmk.1_Missense_Mutation_p.P84L	NM_018093	NP_060563	Q6RFH5	WDR74_HUMAN	WD repeat domain 74	84	WD 2.					nucleolus				ovary(1)	1						CTCCCCGCCCGGGCAGTGTCT	0.632000													3	70					0	0	0.004672	0	0
INPPL1	3636	broad.mit.edu	37	11	71942617	71942617	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr11:71942617G>A	uc001osf.2	+	13	1720	c.1573G>A	c.(1573-1575)GTC>ATC	p.V525I	INPPL1_uc001osg.2_Missense_Mutation_p.V283I	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	525					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						TATCAGCCATGTCAGTACGTC	0.562000													29	58					0	0	0.009535	0	0
DDX11	1663	broad.mit.edu	37	12	31237922	31237922	+	Missense_Mutation	SNP	G	C	C			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr12:31237922G>C	uc001rjt.1	+	5	751	c.500G>C	c.(499-501)AGA>ACA	p.R167T	DDX11_uc010sjw.1_Missense_Mutation_p.R167T|DDX11_uc010sjx.1_RNA|DDX11_uc001rjr.1_Missense_Mutation_p.R167T|DDX11_uc001rjs.1_Missense_Mutation_p.R167T|DDX11_uc001rju.1_5'UTR|DDX11_uc001rjv.1_Missense_Mutation_p.R167T|DDX11_uc001rjw.1_Missense_Mutation_p.R141T|DDX11_uc001rjx.1_5'Flank	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	167	Glu-rich.|Helicase ATP-binding.				G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					GAAGAAGAAAGAGAGAATCTC	0.612000										Multiple Myeloma(12;0.14)			3	22					0	0	0.004672	0	0
LIMA1	51474	broad.mit.edu	37	12	50598436	50598436	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr12:50598436G>A	uc001rwj.3	-	6	937	c.763C>T	c.(763-765)CGA>TGA	p.R255*	LIMA1_uc001rwg.3_5'Flank|LIMA1_uc001rwh.3_Nonsense_Mutation_p.R95*|LIMA1_uc001rwi.3_Nonsense_Mutation_p.R95*|LIMA1_uc001rwk.3_Nonsense_Mutation_p.R255*|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	255					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						TCCAGATTTCGTCTACTCTCA	0.373000													52	63					0	0	0.014410	0	0
C12orf50	160419	broad.mit.edu	37	12	88390403	88390403	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr12:88390403T>C	uc001tam.1	-	5	478	c.310A>G	c.(310-312)AAG>GAG	p.K104E	C12orf50_uc001tan.2_Missense_Mutation_p.K158E	NM_152589	NP_689802	Q8NA57	CL050_HUMAN	hypothetical protein LOC160419	104										skin(2)|ovary(1)	3						TCAGGGGTCTTTGTCCATAAA	0.289000													9	44					0	0	0.008291	0	0
GPR180	160897	broad.mit.edu	37	13	95273351	95273351	+	Silent	SNP	A	G	G			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr13:95273351A>G	uc001vly.2	+	6	834	c.756A>G	c.(754-756)CAA>CAG	p.Q252Q	GPR180_uc001vlz.2_Silent_p.Q151Q|GPR180_uc010afi.2_Silent_p.Q13Q	NM_180989	NP_851320	Q86V85	GP180_HUMAN	G protein-coupled receptor 180 precursor	252	Helical; (Potential).					integral to membrane				breast(1)	1	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					TCGCTTCCCAAATTCAGATGT	0.373000													9	42					0	0	0.010729	0	0
SEL1L	6400	broad.mit.edu	37	14	81946063	81946063	+	Missense_Mutation	SNP	A	C	C			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr14:81946063A>C	uc010tvv.1	-	20	2185	c.2068T>G	c.(2068-2070)TTT>GTT	p.F690V		NM_005065	NP_005056	Q9UBV2	SE1L1_HUMAN	sel-1 suppressor of lin-12-like precursor	690	Lumenal (Potential).|Interaction with ERLEC1, OS9 and SYVN1.|Sel1-like 11.				Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0299)		ATGTCATAAAAACGTTTCGCA	0.383000													11	50					0	0	0.010729	0	0
AEN	64782	broad.mit.edu	37	15	89172463	89172463	+	Missense_Mutation	SNP	A	G	G			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr15:89172463A>G	uc002bmt.2	+	3	698	c.547A>G	c.(547-549)AAG>GAG	p.K183E	AEN_uc010bnm.1_Missense_Mutation_p.K183E	NM_022767	NP_073604	Q8WTP8	AEN_HUMAN	interferon stimulated exonuclease gene	183	Exonuclease.|Nuclear localization signal.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding				0						ACAGATCCTTAAGCTCCTGAA	0.602000													3	143					0	0	0.004672	0	0
ABCA3	21	broad.mit.edu	37	16	2374516	2374516	+	Silent	SNP	G	A	A	rs138952710	by1000genomes	TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr16:2374516G>A	uc002cpy.1	-	6	1048	c.336C>T	c.(334-336)TCC>TCT	p.S112S	ABCA3_uc010bsk.1_Silent_p.S112S|ABCA3_uc010bsl.1_Silent_p.S112S|ABCA3_uc002cpz.1_Silent_p.S112S	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	112					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				AGTCCTTCTCGGAGGGAAAGC	0.587000													23	41					0	0	0.003954	0	0
RAB34	83871	broad.mit.edu	37	17	27042713	27042713	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr17:27042713C>T	uc002hce.2	-	5	949	c.325G>A	c.(325-327)GCT>ACT	p.A109T	RAB34_uc002hcg.2_Missense_Mutation_p.A109T|RAB34_uc002hcf.2_Missense_Mutation_p.A110T|RAB34_uc010was.1_Missense_Mutation_p.A166T|RAB34_uc010wat.1_Missense_Mutation_p.A166T|RAB34_uc002hch.2_Missense_Mutation_p.A109T|RAB34_uc010wau.1_Missense_Mutation_p.A87T|RAB34_uc010wav.1_Missense_Mutation_p.A167T	NM_031934	NP_114140	Q9BZG1	RAB34_HUMAN	Ras-related protein RAB34 isoform 1	109	GTP (By similarity).				protein transport|small GTPase mediated signal transduction	Golgi apparatus	GTP binding				0	Lung NSC(42;0.00431)					TCCTGCCCAGCGGTATCCCAA	0.547000													5	175					0	0	0.000602	0	0
NLE1	54475	broad.mit.edu	37	17	33464163	33464163	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr17:33464163G>A	uc002hiy.1	-	7	713	c.685C>T	c.(685-687)CGG>TGG	p.R229W	NLE1_uc010ctn.1_5'UTR|NLE1_uc002hiz.1_5'UTR	NM_018096	NP_060566	Q9NVX2	NLE1_HUMAN	Notchless gene homolog isoform a	229	WD 3.					nucleolus				breast(3)|ovary(1)	4		Ovarian(249;0.17)				TCCCAGATCCGCACACTGCCA	0.617000													18	32					0	0	0.008871	0	0
Unknown	0	broad.mit.edu	37	17	39296626	39296626	+	RNA	SNP	G	A	A			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr17:39296626G>A	uc010cxk.1	-	1		c.78C>T								Homo sapiens partial mRNA for keratin associated protein 4.6 (KRTAP4.6 gene).																		CACAGCAGCTGGGGCGGCAGC	0.552000													4	160					0	0	0.000602	0	0
ACVR1C	130399	broad.mit.edu	37	2	158401021	158401021	+	Silent	SNP	G	A	A			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr2:158401021G>A	uc002tzk.3	-	5	1122	c.879C>T	c.(877-879)ATC>ATT	p.I293I	ACVR1C_uc002tzl.3_Silent_p.I213I|ACVR1C_uc010fof.2_Silent_p.I136I|ACVR1C_uc010foe.2_Silent_p.I243I	NM_145259	NP_660302	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC isoform 1	293	Protein kinase.|Cytoplasmic (Potential).				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			lung(3)|ovary(2)|skin(2)	7						GCGCCAGCTTGATCATTCCAG	0.398000													4	117					0	0	0.009096	0	0
TTC30A	92104	broad.mit.edu	37	2	178482180	178482180	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr2:178482180T>C	uc002ulo.2	-	1	1515	c.1250A>G	c.(1249-1251)GAT>GGT	p.D417G		NM_152275	NP_689488	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A	417	TPR 5.				cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			CATGGTTTCATCATATTCATT	0.423000													8	240					0	0	0.006214	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								38	43					0	0	0.009718	0	0
CD93	22918	broad.mit.edu	37	20	23066049	23066049	+	Missense_Mutation	SNP	T	G	G			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr20:23066049T>G	uc002wsv.2	-	1	929	c.781A>C	c.(781-783)AAG>CAG	p.K261Q		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	261	EGF-like 1.|Extracellular (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CAGCCATACTTGGGGCTGACA	0.602000													3	155					0	0	0.004672	0	0
FTCD	10841	broad.mit.edu	37	21	47574183	47574183	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr21:47574183C>T	uc002zif.2	-	2	162	c.118G>A	c.(118-120)GCA>ACA	p.A40T	FTCD_uc002zig.2_Missense_Mutation_p.A40T|FTCD_uc002zih.2_Missense_Mutation_p.A40T|FTCD_uc010gqf.2_Missense_Mutation_p.A40T|FTCD_uc010gqg.1_5'UTR	NM_006657	NP_006648	O95954	FTCD_HUMAN	formiminotransferase cyclodeaminase	40	Formiminotransferase N-subdomain (By similarity).				folic acid-containing compound metabolic process|histidine catabolic process	centriole|cytosol|Golgi apparatus	folic acid binding|formimidoyltetrahydrofolate cyclodeaminase activity|glutamate formimidoyltransferase activity			pancreas(1)|skin(1)	2	Breast(49;0.214)			Colorectal(79;0.235)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	GAAGGGCCTGCGTCCACATCC	0.677000													3	44					0	0	0.004672	0	0
TOM1	10043	broad.mit.edu	37	22	35726358	35726358	+	Missense_Mutation	SNP	C	G	G			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr22:35726358C>G	uc003ann.2	+	8	909	c.784C>G	c.(784-786)CGA>GGA	p.R262G	TOM1_uc011ami.1_Missense_Mutation_p.R229G|TOM1_uc011amj.1_Missense_Mutation_p.R105G|TOM1_uc003ans.2_Missense_Mutation_p.R105G|TOM1_uc011amk.1_Missense_Mutation_p.R224G|TOM1_uc003anp.2_Missense_Mutation_p.R262G|TOM1_uc011aml.1_Missense_Mutation_p.R217G|TOM1_uc003ano.2_RNA|TOM1_uc003anq.2_Missense_Mutation_p.R256G|TOM1_uc003anr.2_Missense_Mutation_p.R105G	NM_005488	NP_005479	O60784	TOM1_HUMAN	target of myb1 isoform 1	262	GAT.				endocytosis|endosome transport|intracellular protein transport	cytosol|early endosome|membrane	protein binding			ovary(1)	1						CCGCACGTGCCGAGCCATGCA	0.483000													88	77					0	0	0.014410	0	0
CCR9	10803	broad.mit.edu	37	3	45942529	45942529	+	Silent	SNP	C	T	T			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr3:45942529C>T	uc003coz.1	+	3	406	c.249C>T	c.(247-249)ACC>ACT	p.T83T	LZTFL1_uc003coy.1_Intron|LZTFL1_uc011bak.1_Intron|CCR9_uc010hiv.1_Silent_p.T71T|CCR9_uc003cpa.1_Silent_p.T71T	NM_031200	NP_112477	P51686	CCR9_HUMAN	chemokine (C-C motif) receptor 9 isoform A	83	Cytoplasmic (Potential).				cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane				ovary(2)|breast(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00118)|KIRC - Kidney renal clear cell carcinoma(197;0.0182)|Kidney(197;0.0214)		AGACCATGACCGACATGTTCC	0.507000													12	278					0	0	0.001855	0	0
APEH	327	broad.mit.edu	37	3	49712666	49712666	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr3:49712666C>T	uc003cxf.2	+	3	596	c.196C>T	c.(196-198)CAA>TAA	p.Q66*	APEH_uc010hkw.1_Nonsense_Mutation_p.Q66*	NM_001640	NP_001631	P13798	ACPH_HUMAN	N-acylaminoacyl-peptide hydrolase	66					proteolysis	cytoplasm|nuclear membrane	serine-type endopeptidase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		ATTCTGCCGCCAATACCTGGT	0.572000													34	32					0	0	0.004289	0	0
PIGZ	80235	broad.mit.edu	37	3	196675277	196675277	+	Missense_Mutation	SNP	C	A	A			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr3:196675277C>A	uc003fxh.2	-	3	638	c.491G>T	c.(490-492)GGT>GTT	p.G164V		NM_025163	NP_079439	Q86VD9	PIGZ_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	164	Helical; (Potential).				GPI anchor biosynthetic process	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			ovary(3)	3	all_cancers(143;1.05e-08)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.29e-24)|all cancers(36;2.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00603)		GACGTAGGAACCAGACAGCAG	0.617000													8	27					0.000673444	0.000722422	0.008291	1	0
FRAS1	80144	broad.mit.edu	37	4	79204003	79204003	+	Nonsense_Mutation	SNP	C	A	A			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr4:79204003C>A	uc003hlb.2	+	12	1577	c.1137C>A	c.(1135-1137)TGC>TGA	p.C379*	FRAS1_uc003hkw.2_Nonsense_Mutation_p.C379*|FRAS1_uc003hky.1_Nonsense_Mutation_p.C83*|FRAS1_uc003hkz.2_Nonsense_Mutation_p.C83*	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	379	VWFC 6.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						ATGGCCCTTGCAAGGTGTGTG	0.532000													7	117					0.00307968	0.00324466	0.003080	1	0
NPNT	255743	broad.mit.edu	37	4	106890076	106890076	+	Missense_Mutation	SNP	C	A	A	rs139540458		TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr4:106890076C>A	uc003hya.2	+	12	1832	c.1627C>A	c.(1627-1629)CGT>AGT	p.R543S	NPNT_uc011cfc.1_Missense_Mutation_p.R560S|NPNT_uc011cfd.1_Missense_Mutation_p.R573S|NPNT_uc011cfe.1_Missense_Mutation_p.R544S|NPNT_uc010ilt.1_Intron|NPNT_uc011cff.1_Missense_Mutation_p.R514S|NPNT_uc010ilu.1_Intron	NM_001033047	NP_001028219	Q6UXI9	NPNT_HUMAN	nephronectin precursor	543	MAM.				cell differentiation	membrane	calcium ion binding			skin(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)		TGAAAAAAGGCGTGGTCACAC	0.448000													14	16					2.31682e-05	2.5791e-05	0.003163	1	0
PPP2CA	5515	broad.mit.edu	37	5	133534841	133534841	+	Missense_Mutation	SNP	A	T	T			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr5:133534841A>T	uc003kze.2	-	6	1191	c.793T>A	c.(793-795)TAT>AAT	p.Y265N		NM_002715	NP_002706	P67775	PP2AA_HUMAN	protein phosphatase 2, catalytic subunit, alpha	265					ceramide metabolic process|inactivation of MAPK activity|induction of apoptosis|meiosis|negative regulation of cell growth|negative regulation of epithelial to mesenchymal transition|negative regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of protein serine/threonine kinase activity|protein dephosphorylation|regulation of cell adhesion|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction|spindle pole	metal ion binding|phosphoprotein phosphatase activity			ovary(2)|lung(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Vitamin E(DB00163)	CGATAACAATAGTTTGGAGCA	0.373000													11	93					0	0	0.003163	0	0
KIF20A	10112	broad.mit.edu	37	5	137521298	137521298	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr5:137521298G>A	uc003lcj.2	+	16	2520	c.2024G>A	c.(2023-2025)CGG>CAG	p.R675Q	KIF20A_uc011cyo.1_Missense_Mutation_p.R657Q	NM_005733	NP_005724	O95235	KI20A_HUMAN	kinesin family member 20A	675	Potential.				cytokinesis|M phase of mitotic cell cycle|microtubule-based movement|protein transport|vesicle-mediated transport	Golgi apparatus|microtubule|nucleoplasm	ATP binding|microtubule motor activity|protein binding|transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TTGGCCCTACGGCGGTCACAA	0.507000													45	115					0	0	0.014410	0	0
SH3TC2	79628	broad.mit.edu	37	5	148389859	148389859	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr5:148389859T>C	uc003lpu.2	-	14	3453	c.3301A>G	c.(3301-3303)AGG>GGG	p.R1101G	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc010jgw.2_Missense_Mutation_p.R745G|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_Missense_Mutation_p.R648G|SH3TC2_uc010jgx.2_Missense_Mutation_p.R1094G	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	1101	TPR 5.						binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCATGATGCCTGTGGCGGGTC	0.557000													3	74					0	0	0.009096	0	0
BAT3	7917	broad.mit.edu	37	6	31612853	31612853	+	Missense_Mutation	SNP	A	C	C			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr6:31612853A>C	uc003nvg.3	-	10	1571	c.1257T>G	c.(1255-1257)AAT>AAG	p.N419K	BAT3_uc003nvf.3_Missense_Mutation_p.N413K|BAT3_uc003nvh.3_Missense_Mutation_p.N413K|BAT3_uc003nvi.3_Missense_Mutation_p.N413K|BAT3_uc011dnw.1_Missense_Mutation_p.N413K|BAT3_uc011dnx.1_Missense_Mutation_p.N413K|BAT3_uc003nvj.1_Missense_Mutation_p.N413K	NM_004639	NP_004630	P46379	BAG6_HUMAN	HLA-B associated transcript-3 isoform a	419	4 X 29 AA approximate repeats.|2.|Pro-rich.				apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding				0						AGGACTCGACATTGGTAGAAG	0.662000													55	71					0	0	0.014410	0	0
RFX6	222546	broad.mit.edu	37	6	117246787	117246787	+	Missense_Mutation	SNP	T	A	A			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr6:117246787T>A	uc003pxm.2	+	16	1913	c.1850T>A	c.(1849-1851)TTC>TAC	p.F617Y		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	617					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						CTGCACCAGTTCCCTGCTGGG	0.532000													6	58					0	0	0.001168	0	0
NPC1L1	29881	broad.mit.edu	37	7	44579720	44579720	+	Silent	SNP	G	A	A			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr7:44579720G>A	uc003tlb.2	-	2	332	c.276C>T	c.(274-276)TCC>TCT	p.S92S	NPC1L1_uc003tlc.2_Silent_p.S92S|NPC1L1_uc011kbw.1_Silent_p.S92S|NPC1L1_uc003tld.2_Silent_p.S92S	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	92	Extracellular (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	GCTGCTTGGCGGAGCAGCAGG	0.602000													3	51					0	0	0.004672	0	0
ZNF479	90827	broad.mit.edu	37	7	57187809	57187809	+	Missense_Mutation	SNP	T	G	G			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr7:57187809T>G	uc010kzo.2	-	5	1584	c.1313A>C	c.(1312-1314)AAA>ACA	p.K438T		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	438	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TTCTTCACATTTGTAGGGTCT	0.453000													4	94					0	0	0.009096	0	0
RELN	5649	broad.mit.edu	37	7	103341425	103341425	+	Silent	SNP	T	C	C			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr7:103341425T>C	uc003vca.2	-	9	994	c.834A>G	c.(832-834)TCA>TCG	p.S278S	RELN_uc010liz.2_Silent_p.S278S	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	278					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGCTGGGGTCTGAATAACTAA	0.313000													3	137					0	0	0.001168	0	0
SRPK2	6733	broad.mit.edu	37	7	104783594	104783594	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr7:104783594C>T	uc003vct.2	-	9	1151	c.964G>A	c.(964-966)GAG>AAG	p.E322K	SRPK2_uc003vcu.2_Missense_Mutation_p.E322K|SRPK2_uc003vcv.2_Missense_Mutation_p.E333K|SRPK2_uc003vcw.1_Missense_Mutation_p.E322K	NM_182691	NP_872633	P78362	SRPK2_HUMAN	serine/arginine-rich protein-specific kinase 2	322	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(3)|ovary(2)|upper_aerodigestive_tract(1)	6						AGTTTCACCTCTGGGCAGTAT	0.498000													14	83					0	0	0.004007	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37730001	37730001	+	Silent	SNP	G	A	A			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr8:37730001G>A	uc003xkm.1	-	4	2363	c.2319C>T	c.(2317-2319)CCC>CCT	p.P773P	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Intron|RAB11FIP1_uc003xkl.1_Silent_p.P102P|RAB11FIP1_uc003xko.1_Silent_p.P102P|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	773					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			TGGGAAGAGGGGGCGCCACTT	0.557000													27	61					0	0	0.010818	0	0
TEK	7010	broad.mit.edu	37	9	27172734	27172734	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr9:27172734C>T	uc003zqi.3	+	5	1191	c.749C>T	c.(748-750)ACG>ATG	p.T250M	TEK_uc010mjc.1_Missense_Mutation_p.T103M|TEK_uc011lnn.1_Missense_Mutation_p.T250M|TEK_uc011lno.1_Missense_Mutation_p.T250M|TEK_uc011lnp.1_Missense_Mutation_p.T146M|TEK_uc003zqj.1_Missense_Mutation_p.T227M	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	250	Extracellular (Potential).|EGF-like 1.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		ATGGGAAGGACGTGTGAGAAG	0.433000													3	51					0	0	0.009096	0	0
ARID1A	8289	broad.mit.edu	37	1	27106229	27106230	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr1:27106229_27106230delAG	uc001bmv.1	+	20	6213_6214	c.5840_5841delAG	c.(5839-5841)CAGfs	p.Q1947fs	ARID1A_uc001bmu.1_Frame_Shift_Del_p.Q1730fs|ARID1A_uc001bmx.1_Frame_Shift_Del_p.Q793fs|ARID1A_uc009vsm.1_Frame_Shift_Del_p.Q275fs|ARID1A_uc009vsn.1_Frame_Shift_Del_p.Q189fs	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1947					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		AGCCCAGCACAGAGCCACCGGA	0.530			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								22	137	---	---	---	---					
Unknown	0	broad.mit.edu	37	10	46671772	46671772	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr10:46671772delT	uc001jdv.2	-	3	419	c.284delA	c.(283-285)AAGfs	p.K95fs	uc009xmy.1_Frame_Shift_Del_p.K36fs	NM_001042524	NP_001035989			FERM and PDZ domain containing 2 like 1 isoform																		ATTGGCATTCTTTTTTAGTTT	0.398													5	8	---	---	---	---					
HDGFRP2	84717	broad.mit.edu	37	19	4493799	4493801	+	In_Frame_Del	DEL	TCC	-	-			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr19:4493799_4493801delTCC	uc002mao.2	+	7	871_873	c.778_780delTCC	c.(778-780)TCCdel	p.S264del	HDGFRP2_uc002map.2_In_Frame_Del_p.S264del|HDGFRP2_uc010dtz.1_RNA	NM_001001520	NP_001001520	Q7Z4V5	HDGR2_HUMAN	hepatoma-derived growth factor-related protein 2	264	Ser-rich.				transcription, DNA-dependent	nucleus	DNA binding|protein binding				0						ctcctcctcttcctcctcctcct	0.581													2	4	---	---	---	---					
ZBTB20	26137	broad.mit.edu	37	3	114058002	114058003	+	Frame_Shift_Ins	INS	-	G	G			TCGA-FG-7637-01A-11D-2086-08	TCGA-FG-7637-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	aea26718-ba34-444f-9122-0faf73b62ea1	c2346512-f289-4ac1-a8c9-460c4f3f0126	g.chr3:114058002_114058003insG	uc003ebi.2	-	5	2255_2256	c.2075_2076insC	c.(2074-2076)CCTfs	p.P692fs	ZBTB20_uc003ebj.2_Frame_Shift_Ins_p.P619fs|ZBTB20_uc010hqp.2_Frame_Shift_Ins_p.P619fs|ZBTB20_uc003ebk.2_Frame_Shift_Ins_p.P619fs|ZBTB20_uc003ebl.2_Frame_Shift_Ins_p.P619fs|ZBTB20_uc003ebm.2_Frame_Shift_Ins_p.P619fs|ZBTB20_uc003ebn.2_Frame_Shift_Ins_p.P619fs	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	692					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		GTGTGCCTGCAGGGGGGGTCCC	0.634													19	43	---	---	---	---					
