Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CROCCL1	84809	broad.mit.edu	37	1	16946434	16946434	+	RNA	SNP	C	T	T	rs367060		TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr1:16946434C>T	uc010ocf.1	-	3		c.464G>A			CROCCL1_uc009vov.1_RNA|CROCCL1_uc001aze.2_RNA|CROCCL1_uc001azf.2_RNA					Homo sapiens mRNA for FLJ00313 protein.												0						CTCAGCCTTCCGCCGGGCCAG	0.672000													4	19					0	0	0.021553	0	0
KCNQ4	9132	broad.mit.edu	37	1	41283890	41283890	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr1:41283890G>A	uc001cgh.1	+	3	542	c.460G>A	c.(460-462)GCC>ACC	p.A154T	KCNQ4_uc001cgi.1_Missense_Mutation_p.A154T	NM_004700	NP_004691	P56696	KCNQ4_HUMAN	potassium voltage-gated channel KQT-like protein	154	Cytoplasmic.				sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			GGTCTGGTCCGCCGGATGCTG	0.612000													20	52					0	0	0.108266	0	0
DMBX1	127343	broad.mit.edu	37	1	46977833	46977833	+	Silent	SNP	G	A	A			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr1:46977833G>A	uc001cpx.2	+	4	831	c.816G>A	c.(814-816)CAG>CAA	p.Q272Q	DMBX1_uc001cpw.2_Silent_p.Q267Q	NM_147192	NP_671725	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1 isoform b	272					brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					AATTCCGCCAGCACATGGCGG	0.672000													3	57					0	0	0.115264	0	0
OLFML2B	25903	broad.mit.edu	37	1	161954740	161954740	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr1:161954740G>A	uc001gbu.2	-	7	1929	c.1505C>T	c.(1504-1506)ACG>ATG	p.T502M	OLFML2B_uc001gbt.2_Translation_Start_Site|OLFML2B_uc010pkq.1_Missense_Mutation_p.T503M	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	502	Olfactomedin-like.									skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			GGTCGGCCCCGTGATTGTGGA	0.537000													4	168					0	0	0.184627	0	0
OBSCN	84033	broad.mit.edu	37	1	228528833	228528833	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr1:228528833G>A	uc009xez.1	+	73	17779	c.17735G>A	c.(17734-17736)CGC>CAC	p.R5912H	OBSCN_uc001hsn.2_Missense_Mutation_p.R5912H|OBSCN_uc001hsr.1_Missense_Mutation_p.R541H	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	5912	PH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CCGGGGGCCCGCATGCCCTGG	0.677000													3	41					0	0	0.115264	0	0
MIR1182	100302132	broad.mit.edu	37	1	231155648	231155648	+	RNA	SNP	G	A	A			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr1:231155648G>A	hsa-mir-1182|MI0006275	-			c.23G>A			FAM89A_uc001hui.2_Silent_p.S172S|FAM89A_uc009xfm.2_Silent_p.S183S																	0						TGGAGAGGGAGGAGACAGGCA	0.567000													3	54					0	0	0.150653	0	0
LARP4B	23185	broad.mit.edu	37	10	866757	866757	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr10:866757T>C	uc001ifs.1	-	13	1554	c.1513A>G	c.(1513-1515)AGG>GGG	p.R505G		NM_015155	NP_055970	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	505							nucleotide binding|RNA binding			ovary(2)|central_nervous_system(1)	3						TTCTCCTCCCTTTTCTTCCGG	0.348000													3	76					0	0	0.115264	0	0
CUBN	8029	broad.mit.edu	37	10	16992025	16992025	+	Silent	SNP	G	A	A			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr10:16992025G>A	uc001ioo.2	-	34	5107	c.5055C>T	c.(5053-5055)GGC>GGT	p.G1685G		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1685	CUB 11.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CTTCGTGGCCGCCATCCAAAA	0.448000													11	31					0	0	0.132662	0	0
OR8K1	390157	broad.mit.edu	37	11	56114203	56114203	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr11:56114203C>T	uc010rjg.1	+	1	689	c.689C>T	c.(688-690)GCC>GTC	p.A230V		NM_001002907	NP_001002907	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K,	230	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					ATTCTAGTGGCCATTCTCAGA	0.383000										HNSCC(65;0.19)			26	47					0	0	0.099896	0	0
ABCG4	64137	broad.mit.edu	37	11	119025013	119025013	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr11:119025013C>T	uc001pvs.2	+	4	736	c.400C>T	c.(400-402)CGG>TGG	p.R134W	ABCG4_uc009zar.2_Missense_Mutation_p.R134W	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	134	Cytoplasmic (Potential).|ABC transporter.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		TGGAAGGCCACGGGAGCTGAG	0.557000													7	71					0	0	0.029380	0	0
DCP1B	196513	broad.mit.edu	37	12	2062350	2062350	+	Missense_Mutation	SNP	C	G	G			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr12:2062350C>G	uc001qjx.1	-	7	836	c.756G>C	c.(754-756)CAG>CAC	p.Q252H	DCP1B_uc010sdy.1_Missense_Mutation_p.Q150H	NM_152640	NP_689853	Q8IZD4	DCP1B_HUMAN	decapping enzyme Dcp1b	252	Poly-Gln.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			gctgctgctgctgGTGGAGAG	0.458000													4	51					0	0	0.150653	0	0
GRIN2B	2904	broad.mit.edu	37	12	13906506	13906506	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr12:13906506T>C	uc001rbt.2	-	3	934	c.755A>G	c.(754-756)TAT>TGT	p.Y252C		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	252	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CGTGTAGCCATAGCCAGTCAG	0.512000													3	152					0	0	0.115264	0	0
KIF21A	55605	broad.mit.edu	37	12	39727057	39727057	+	Missense_Mutation	SNP	T	G	G			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr12:39727057T>G	uc001rly.2	-	18	2590	c.2444A>C	c.(2443-2445)CAA>CCA	p.Q815P	KIF21A_uc001rlv.2_5'Flank|KIF21A_uc001rlw.2_Missense_Mutation_p.Q132P|KIF21A_uc001rlx.2_Missense_Mutation_p.Q802P|KIF21A_uc001rlz.2_Intron|KIF21A_uc010skl.1_Missense_Mutation_p.Q802P	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	815					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				GTTTCTTTTTTGGGCTTCCAG	0.323000													3	181					0	0	0.150653	0	0
TEKT1	83659	broad.mit.edu	37	17	6703471	6703471	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr17:6703471C>T	uc002gdt.2	-	8	1242	c.1132G>A	c.(1132-1134)GTC>ATC	p.V378I	TEKT1_uc010vth.1_Missense_Mutation_p.V232I	NM_053285	NP_444515	Q969V4	TEKT1_HUMAN	tektin 1	378	Potential.				microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|skin(1)	2		Myeloproliferative disorder(207;0.0255)				TTCTCTTTGACCTGGATCTCC	0.527000													11	125					0	0	0.105934	0	0
PBX4	80714	broad.mit.edu	37	19	19672911	19672911	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr19:19672911G>A	uc002nmy.2	-	8	1049	c.1048C>T	c.(1048-1050)CAG>TAG	p.Q350*	PBX4_uc010xqz.1_RNA|PBX4_uc010xra.1_Nonsense_Mutation_p.Q185*	NM_025245	NP_079521	Q9BYU1	PBX4_HUMAN	pre-B-cell leukemia homeobox 4	350							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2						GTGGCCCCCTGCCAGCTACCC	0.597000													4	22					0	0	0.150653	0	0
HOXD3	3232	broad.mit.edu	37	2	177034190	177034190	+	Silent	SNP	A	G	G			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr2:177034190A>G	uc002ukt.1	+	2	524	c.348A>G	c.(346-348)CCA>CCG	p.P116P		NM_006898	NP_008829	P31249	HXD3_HUMAN	homeobox D3	116	Poly-Pro.				anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		AGCAGCAGccaccacaacccc	0.478000													17	44					0	0	0.160694	0	0
ZDBF2	57683	broad.mit.edu	37	2	207175936	207175936	+	Silent	SNP	G	A	A			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr2:207175936G>A	uc002vbp.2	+	5	6934	c.6684G>A	c.(6682-6684)TCG>TCA	p.S2228S		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	2228							nucleic acid binding|zinc ion binding			ovary(3)	3						AGTATATTTCGAAATACTCTG	0.363000													10	15					0	0	0.080935	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								34	92					0	0	0.104719	0	0
RIPK4	54101	broad.mit.edu	37	21	43166845	43166845	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr21:43166845C>T	uc002yzn.1	-	5	808	c.760G>A	c.(760-762)GCC>ACC	p.A254T		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	254						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						TGGCTGCAGGCGCGCGGCCGG	0.672000													55	78					0	0	0.139131	0	0
ZNF295	49854	broad.mit.edu	37	21	43411483	43411483	+	Silent	SNP	G	A	A			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr21:43411483G>A	uc002zab.3	-	3	2936	c.2722C>T	c.(2722-2724)CTG>TTG	p.L908L	ZNF295_uc002yzz.3_Silent_p.L707L|ZNF295_uc002yzy.3_Silent_p.L908L|ZNF295_uc002zaa.3_Silent_p.L908L	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	908					negative regulation of transcription, DNA-dependent|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|nucleus	methyl-CpG binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CAGGGCCACAGGCTGGCTTCT	0.552000													7	98					0	0	0.047766	0	0
ZBTB20	26137	broad.mit.edu	37	3	114058129	114058129	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr3:114058129T>C	uc003ebi.2	-	5	2129	c.1949A>G	c.(1948-1950)AAC>AGC	p.N650S	ZBTB20_uc003ebj.2_Missense_Mutation_p.N577S|ZBTB20_uc010hqp.2_Missense_Mutation_p.N577S|ZBTB20_uc003ebk.2_Missense_Mutation_p.N577S|ZBTB20_uc003ebl.2_Missense_Mutation_p.N577S|ZBTB20_uc003ebm.2_Missense_Mutation_p.N577S|ZBTB20_uc003ebn.2_Missense_Mutation_p.N577S	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	650	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		CATGTGCACGTTGAGGGAGCT	0.527000													4	234					0	0	0.184627	0	0
PIK3CA	5290	broad.mit.edu	37	3	178952085	178952085	+	Missense_Mutation	SNP	A	G	G	rs121913279		TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr3:178952085A>G	uc003fjk.2	+	21	3297	c.3140A>G	c.(3139-3141)CAT>CGT	p.H1047R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1269)|p.H1047L(152)|p.H1047Y(31)|p.H1047Q(3)|p.H1047T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378000	H1047R(BT20_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(MCAS_OVARY)|H1047R(HCC1954_BREAST)|H1047R(RKO_LARGE_INTESTINE)|H1047L(EFM19_BREAST)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(CAL29_URINARY_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(T47D_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(SKOV3_OVARY)|H1047R(MDAMB453_BREAST)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			8	94					0	0	0.038147	0	0
FAT1	2195	broad.mit.edu	37	4	187628151	187628151	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr4:187628151G>A	uc003izf.2	-	2	3019	c.2831C>T	c.(2830-2832)ACC>ATC	p.T944I	FAT1_uc010iso.1_Missense_Mutation_p.T944I	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	944	Extracellular (Potential).|Cadherin 8.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CATGATGACGGTTCCTTCTGG	0.453000										HNSCC(5;0.00058)			5	284					0	0	0.184627	0	0
ZNF165	7718	broad.mit.edu	37	6	28053480	28053480	+	Silent	SNP	C	T	T	rs140146788		TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr6:28053480C>T	uc003nkg.2	+	3	1306	c.222C>T	c.(220-222)TGC>TGT	p.C74C	ZNF165_uc003nkh.2_Silent_p.C74C|ZNF165_uc003nki.3_Silent_p.C74C	NM_003447	NP_003438	P49910	ZN165_HUMAN	zinc finger protein 165	74	SCAN box.				viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGGAGCTCTGCTGTCAGTGGC	0.562000													3	58					0	0	0.115264	0	0
ZNF192	7745	broad.mit.edu	37	6	28121261	28121261	+	Silent	SNP	T	G	G			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr6:28121261T>G	uc003nkn.1	+	6	1387	c.1203T>G	c.(1201-1203)ACT>ACG	p.T401T	ZNF192_uc010jqx.1_Silent_p.T401T|ZNF192_uc010jqy.1_Silent_p.T214T|ZNF192_uc011dkz.1_Silent_p.T214T	NM_006298	NP_006289	Q15776	ZN192_HUMAN	zinc finger protein 192	401					viral reproduction	cytoplasm|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GAATCCACACTGGGGAGAAGC	0.493000													8	145					0	0	0.091800	0	0
PIK3CG	5294	broad.mit.edu	37	7	106520010	106520010	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr7:106520010T>C	uc003vdv.3	+	6	2523	c.2438T>C	c.(2437-2439)CTT>CCT	p.L813P	PIK3CG_uc003vdu.2_Missense_Mutation_p.L813P|PIK3CG_uc003vdw.2_Missense_Mutation_p.L813P	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	813					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						CCACTATGGCTTGAGTTTAAA	0.368000													3	85					0	0	0.150653	0	0
FOXP2	93986	broad.mit.edu	37	7	114270000	114270000	+	Silent	SNP	G	A	A			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr7:114270000G>A	uc003vhb.2	+	5	911	c.537G>A	c.(535-537)CAG>CAA	p.Q179Q	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Silent_p.Q204Q|FOXP2_uc003vha.2_Silent_p.Q87Q|FOXP2_uc011kmu.1_Silent_p.Q196Q|FOXP2_uc011kmv.1_Silent_p.Q179Q|FOXP2_uc010ljz.1_Silent_p.Q87Q|FOXP2_uc003vgt.1_RNA|FOXP2_uc003vgv.1_Silent_p.Q179Q|FOXP2_uc003vgx.2_Silent_p.Q179Q|FOXP2_uc003vhd.2_Silent_p.Q179Q|FOXP2_uc003vhc.2_Silent_p.Q204Q	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	179	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						agcaacaacagcagcagcagc	0.159000													6	40					0	0	0.021553	0	0
XKR6	286046	broad.mit.edu	37	8	10755970	10755970	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr8:10755970G>A	uc003wtk.1	-	3	1445	c.1418C>T	c.(1417-1419)GCG>GTG	p.A473V		NM_173683	NP_775954	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related	473	Helical; (Potential).					integral to membrane				ovary(1)|skin(1)	2				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		TGCTGGCACCGCATAGGAGTC	0.473000													3	39					0	0	0.150653	0	0
CERCAM	51148	broad.mit.edu	37	9	131186792	131186792	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr9:131186792G>A	uc004buz.3	+	5	1063	c.665G>A	c.(664-666)CGG>CAG	p.R222Q	CERCAM_uc004buy.1_Missense_Mutation_p.R144Q|CERCAM_uc010mxz.2_Missense_Mutation_p.R144Q|CERCAM_uc010mya.1_Missense_Mutation_p.R63Q	NM_016174	NP_057258	Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule 1	222					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				pancreas(1)	1						GCATCCCTGCGGGCTGAAGGG	0.617000													39	68					0	0	0.086207	0	0
TMTC4	84899	broad.mit.edu	37	13	101257337	101257339	+	In_Frame_Del	DEL	AGG	-	-			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr13:101257337_101257339delAGG	uc001vou.2	-	18	2295_2297	c.2135_2137delCCT	c.(2134-2139)TCCTTG>TTG	p.S712del	TMTC4_uc001vot.2_In_Frame_Del_p.S731del|TMTC4_uc010tja.1_In_Frame_Del_p.S601del	NM_001079669	NP_001073137	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat	712	TPR 8.					integral to membrane	binding			ovary(2)|breast(1)	3	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TCAAGCTGCAAGGAGATTTCATA	0.438													23	255	---	---	---	---					
KIAA0391	9692	broad.mit.edu	37	14	35592700	35592700	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr14:35592700delT	uc001wsy.1	+	2	609	c.249delT	c.(247-249)CATfs	p.H83fs	KIAA0391_uc010tps.1_Intron|KIAA0391_uc001wsz.1_Frame_Shift_Del_p.H83fs|KIAA0391_uc001wta.2_RNA|KIAA0391_uc001wtb.1_Frame_Shift_Del_p.H83fs|KIAA0391_uc001wtc.1_Intron|PPP2R3C_uc001wss.2_5'Flank|PPP2R3C_uc001wst.2_5'Flank|PPP2R3C_uc010tpr.1_5'Flank|PPP2R3C_uc001wsu.2_5'Flank|PPP2R3C_uc010amn.1_5'Flank|PPP2R3C_uc001wsw.2_5'Flank|PPP2R3C_uc001wsx.1_5'Flank	NM_014672	NP_055487	O15091	MRRP3_HUMAN	mitochondrial RNase P protein 3 precursor	83					tRNA processing	mitochondrion					0	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;2.93e-05)|LUAD - Lung adenocarcinoma(48;3.86e-05)|Epithelial(34;0.0114)|all cancers(34;0.0277)	GBM - Glioblastoma multiforme(112;0.0593)		CTGTTCCTCATTTTTTTTTAG	0.423													10	62	---	---	---	---					
IL32	9235	broad.mit.edu	37	16	3119304	3119305	+	Frame_Shift_Ins	INS	-	G	G	rs2981599		TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr16:3119304_3119305insG	uc002cto.2	+	6	864_865	c.653_654insG	c.(652-654)GACfs	p.D218fs	IL32_uc002ctk.2_Frame_Shift_Ins_p.D115fs|IL32_uc010uwp.1_Frame_Shift_Ins_p.D152fs|IL32_uc010btb.2_Frame_Shift_Ins_p.D162fs|IL32_uc002ctl.2_Frame_Shift_Ins_p.D172fs|IL32_uc002ctm.2_Frame_Shift_Ins_p.D172fs|IL32_uc002ctn.2_Frame_Shift_Ins_p.D172fs|IL32_uc002cts.3_Frame_Shift_Ins_p.D172fs|IL32_uc002ctp.2_Frame_Shift_Ins_p.D152fs|IL32_uc002ctq.2_Frame_Shift_Ins_p.D218fs|IL32_uc002ctr.2_Frame_Shift_Ins_p.D152fs|IL32_uc002ctt.2_Frame_Shift_Ins_p.D172fs|IL32_uc010uwr.1_Frame_Shift_Ins_p.D132fs|IL32_uc002ctu.2_Frame_Shift_Ins_p.D163fs	NM_004221	NP_004212	P24001	IL32_HUMAN	interleukin 32 isoform B	218					cell adhesion|defense response|immune response	extracellular space	cytokine activity			pancreas(1)	1						CCACGGGGGGACAAGGAGGAGC	0.574													30	394	---	---	---	---					
RIF1	55183	broad.mit.edu	37	2	152293790	152293790	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FG-8187-01A-11D-2253-08	TCGA-FG-8187-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	03ef1338-e963-4cc2-a596-27334a685da3	ae886eb1-4d03-4bb3-b9b4-ad379272ab7a	g.chr2:152293790delT	uc002txm.2	+	13	1538	c.1408delT	c.(1408-1410)TTTfs	p.F470fs	RIF1_uc002txl.2_Frame_Shift_Del_p.F470fs|RIF1_uc010fnv.1_Frame_Shift_Del_p.F434fs|RIF1_uc002txn.2_Frame_Shift_Del_p.F470fs|RIF1_uc002txo.2_Frame_Shift_Del_p.F470fs|RIF1_uc010zby.1_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	470					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		CAGCCCTTCCTTTTTTTCCAA	0.343													7	264	---	---	---	---					
