Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LMNA	4000	broad.mit.edu	37	1	156104684	156104684	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr1:156104684A>G	uc001fni.2	+	4	977	c.728A>G	c.(727-729)GAT>GGT	p.D243G	LMNA_uc001fnf.1_Missense_Mutation_p.D243G|LMNA_uc001fng.2_Missense_Mutation_p.D243G|LMNA_uc001fnh.2_Missense_Mutation_p.D243G|LMNA_uc009wro.1_Missense_Mutation_p.D243G|LMNA_uc010pgz.1_Missense_Mutation_p.D131G|LMNA_uc001fnj.2_Missense_Mutation_p.D162G|LMNA_uc001fnk.2_Missense_Mutation_p.D144G|LMNA_uc009wrp.2_5'Flank|LMNA_uc010pha.1_5'Flank	NM_170707	NP_733821	P02545	LMNA_HUMAN	lamin A/C isoform 1 precursor	243	Coil 2.|Rod.				cellular component disassembly involved in apoptosis|cellular response to hypoxia|establishment or maintenance of microtubule cytoskeleton polarity|muscle organ development|positive regulation of cell aging|regulation of apoptosis|regulation of cell migration	cytoplasm|lamin filament|nuclear envelope|nuclear envelope|perinuclear region of cytoplasm	protein binding|structural molecule activity|structural molecule activity			ovary(2)	2	Hepatocellular(266;0.158)					CGGCTGGCGGATGCGCTGCAG	0.582000									Werner_syndrome|Hutchinson-Gilford_Progeria_Syndrome				19	77					0	0	0.018920	0	0
CR1	1378	broad.mit.edu	37	1	207787753	207787753	+	Nonsense_Mutation	SNP	C	T	T	rs55749440		TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr1:207787753C>T	uc001hfy.2	+	32	5370	c.5230C>T	c.(5230-5232)CGA>TGA	p.R1744*	CR1_uc001hfx.2_Nonsense_Mutation_p.R2194*	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1744	Extracellular (Potential).|Sushi 27.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						CTTTAGGTTCCGATTAAAAGG	0.423000													3	61					0	0	0.009096	0	0
C1orf65	164127	broad.mit.edu	37	1	223567391	223567391	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr1:223567391C>T	uc001hoa.2	+	1	677	c.574C>T	c.(574-576)CGG>TGG	p.R192W		NM_152610	NP_689823	Q8N715	CA065_HUMAN	hypothetical protein LOC164127	192										central_nervous_system(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0704)		TCCCTCGGAGCGGTCTTCTGT	0.597000													53	71					0	0	0.014410	0	0
KCNK18	338567	broad.mit.edu	37	10	118957048	118957048	+	Silent	SNP	C	T	T			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr10:118957048C>T	uc010qsr.1	+	1	49	c.49C>T	c.(49-51)CTG>TTG	p.L17L		NM_181840	NP_862823	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	17	Cytoplasmic (Potential).					integral to membrane|plasma membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;0.19)		all cancers(201;0.0211)		CCCAGAGGCCCTGGGAAAGCT	0.632000													4	68					0	0	0.014758	0	0
IKZF5	64376	broad.mit.edu	37	10	124753508	124753508	+	Missense_Mutation	SNP	T	G	G			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr10:124753508T>G	uc001lha.2	-	5	1347	c.1048A>C	c.(1048-1050)ACC>CCC	p.T350P	IKZF5_uc001lgz.2_Missense_Mutation_p.T188P	NM_022466	NP_071911	Q9H5V7	IKZF5_HUMAN	zinc finger protein, subfamily 1A, 5	350					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_neural(114;0.169)|Colorectal(57;0.178)|Glioma(114;0.222)		Colorectal(40;0.0701)|COAD - Colon adenocarcinoma(40;0.0754)		GGGGCTGGGGTGCTTGGCTGG	0.547000													6	60					0	0	0.005443	0	0
PRPF40B	25766	broad.mit.edu	37	12	50036431	50036431	+	Silent	SNP	C	G	G			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr12:50036431C>G	uc001rur.1	+	20	2089	c.2025C>G	c.(2023-2025)CTC>CTG	p.L675L	FMNL3_uc001ruv.1_3'UTR|FMNL3_uc001ruw.1_3'UTR|PRPF40B_uc001rup.1_Silent_p.L697L|PRPF40B_uc001ruq.1_Silent_p.L662L|PRPF40B_uc001rus.1_Silent_p.L618L|FMNL3_uc001rut.1_3'UTR|FMNL3_uc001ruu.1_3'UTR	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	675					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						GGATCCGGCTCTTCCGGGAGT	0.557000													25	24					0	0	0.006320	0	0
C12orf12	196477	broad.mit.edu	37	12	91347873	91347873	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr12:91347873G>A	uc001tbj.2	-	1	1081	c.647C>T	c.(646-648)GCG>GTG	p.A216V		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	216	Potential.									central_nervous_system(1)|pancreas(1)	2						GGCCTTCTGCGCCCGCAGCGC	0.647000													4	109					0	0	0.009096	0	0
EIF2B1	1967	broad.mit.edu	37	12	124111689	124111689	+	Silent	SNP	G	A	A	rs146748240	byFrequency	TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr12:124111689G>A	uc001ufm.2	-	5	527	c.384C>T	c.(382-384)CAC>CAT	p.H128H	EIF2B1_uc001ufn.2_Silent_p.H128H|EIF2B1_uc010tat.1_Silent_p.H128H	NM_001414	NP_001405	Q14232	EI2BA_HUMAN	eukaryotic translation initiation factor 2B,	128					cellular response to stimulus|oligodendrocyte development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex|membrane fraction|plasma membrane	protein binding|translation initiation factor activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.67e-05)|Epithelial(86;0.000353)|all cancers(50;0.00489)		TGGAGTAGGCGTGAGTCAATA	0.562000													8	120					0	0	0.006214	0	0
EP400NL	347918	broad.mit.edu	37	12	132589649	132589649	+	Missense_Mutation	SNP	C	T	T	rs34521142	by1000genomes	TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr12:132589649C>T	uc001ujv.2	+	1	1108	c.1084C>T	c.(1084-1086)CAC>TAC	p.H362Y	EP400NL_uc001ujr.2_Missense_Mutation_p.H230Y|EP400NL_uc001ujs.3_Missense_Mutation_p.H293Y|EP400NL_uc009zyq.2_Missense_Mutation_p.H230Y|EP400NL_uc001ujt.2_Missense_Mutation_p.H230Y|EP400NL_uc001ujw.1_Missense_Mutation_p.H61Y					RecName: Full=EP400 N-terminal-like protein;												0						GGACTATCATCACCAGGAGAT	0.478000													3	22					0	0	0.004672	0	0
TSHR	7253	broad.mit.edu	37	14	81609744	81609744	+	Missense_Mutation	SNP	G	A	A	rs146403935	by1000genomes	TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr14:81609744G>A	uc001xvd.1	+	10	1498	c.1342G>A	c.(1342-1344)GTC>ATC	p.V448I		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	448	Cytoplasmic (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	CAAACTGAACGTCCCCCGCTT	0.517000			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						12	163					0	0	0.020292	0	0
KLHL25	64410	broad.mit.edu	37	15	86312652	86312652	+	Silent	SNP	G	A	A			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr15:86312652G>A	uc002bly.2	-	2	593	c.390C>T	c.(388-390)CAC>CAT	p.H130H		NM_022480	NP_071925	Q9H0H3	ENC2_HUMAN	BTB/POZ KELCH domain protein	130						cytoplasm				ovary(2)	2						CCCGCACATCGTGGAACTGCA	0.622000													10	53					0	0	0.008291	0	0
PRDM7	11105	broad.mit.edu	37	16	90126823	90126823	+	Missense_Mutation	SNP	T	G	G			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr16:90126823T>G	uc010cje.2	-	9	1179	c.1159A>C	c.(1159-1161)ATG>CTG	p.M387L	PRDM7_uc002fqo.2_Intron|PRDM7_uc010cjf.2_Intron|PRDM7_uc010cjg.1_Missense_Mutation_p.M181L	NM_001098173	NP_001091643	Q9NQW5	PRDM7_HUMAN	PR domain containing 7 isoform 1	387						chromosome|nucleus	nucleic acid binding			ovary(1)	1		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CTCATCCCCATACCAGACCAG	0.522000													5	124					0	0	0.014758	0	0
MYH8	4626	broad.mit.edu	37	17	10299697	10299697	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr17:10299697G>A	uc002gmm.2	-	33	4698	c.4603C>T	c.(4603-4605)CAA>TAA	p.Q1535*	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1535	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TGTTCTACTTGCTTCTTTATT	0.383000									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				5	24					0	0	0.001168	0	0
NF1	4763	broad.mit.edu	37	17	29562639	29562639	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr17:29562639C>G	uc002hgg.2	+	28	4052	c.3719C>G	c.(3718-3720)GCT>GGT	p.A1240G	NF1_uc002hgh.2_Missense_Mutation_p.A1240G|NF1_uc010csn.1_Missense_Mutation_p.A1100G|NF1_uc002hgi.1_Missense_Mutation_p.A273G	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1240	Ras-GAP.				actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GATGAACTAGCTCGAGTTCTG	0.383000			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			10	250					0	0	0.016723	0	0
KRT15	3866	broad.mit.edu	37	17	39673185	39673185	+	Missense_Mutation	SNP	C	T	T	rs138271368		TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr17:39673185C>T	uc002hwy.2	-	3	804	c.613G>A	c.(613-615)GTT>ATT	p.V205I	KRT15_uc002hwz.2_Missense_Mutation_p.V107I|KRT15_uc002hxa.2_Missense_Mutation_p.V40I|KRT15_uc002hxb.1_Missense_Mutation_p.V40I	NM_002275	NP_002266	P19012	K1C15_HUMAN	keratin 15	205	Rod.|Coil 1B.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000286)				TCAGCCTCAACGCCCTGGCGC	0.612000													13	69					0	0	0.003163	0	0
ABCA10	10349	broad.mit.edu	37	17	67189985	67189985	+	Silent	SNP	T	C	C			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr17:67189985T>C	uc010dfa.1	-	14	2370	c.1491A>G	c.(1489-1491)AAA>AAG	p.K497K	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Silent_p.K98K	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	497	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					GCTGAATCCCTTTTATTTTAG	0.328000													3	137					0	0	0.004672	0	0
POTEC	388468	broad.mit.edu	37	18	14543092	14543092	+	Silent	SNP	G	A	A	rs45502401		TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr18:14543092G>A	uc010dln.2	-	1	508	c.54C>T	c.(52-54)TTC>TTT	p.F18F	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	18										skin(3)	3						TCCTGAGATCGAATGGCTTCT	0.572000													5	112					0	0	0.003080	0	0
DNM2	1785	broad.mit.edu	37	19	10908139	10908139	+	Missense_Mutation	SNP	G	T	T			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr19:10908139G>T	uc002mps.1	+	10	1444	c.1280G>T	c.(1279-1281)TGT>TTT	p.C427F	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Intron|DNM2_uc002mpv.1_Missense_Mutation_p.C427F|DNM2_uc002mpu.1_Intron|DNM2_uc010dxl.1_Intron|DNM2_uc002mpw.2_Missense_Mutation_p.C160F	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	427					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			AGTTTGAAGTGTGTTGATCTC	0.517000													19	63					6.44725e-10	7.06128e-10	0.014323	1	0
AXL	558	broad.mit.edu	37	19	41763470	41763470	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr19:41763470G>A	uc010ehj.2	+	19	2459	c.2269G>A	c.(2269-2271)GAG>AAG	p.E757K	CYP2F1_uc010xvw.1_Intron|AXL_uc010ehk.2_Missense_Mutation_p.E748K	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	757	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						GGAGAACAGCGAGATTTATGA	0.557000													5	98					0	0	0.003080	0	0
CCDC8	83987	broad.mit.edu	37	19	46914959	46914959	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr19:46914959T>C	uc002pep.2	-	1	1961	c.1109A>G	c.(1108-1110)GAG>GGG	p.E370G		NM_032040	NP_114429	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	370						plasma membrane				ovary(3)	3				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		AGCTGGGGCCTCTGCCCTCTG	0.607000													3	107					0	0	0.009096	0	0
PPP2R1A	5518	broad.mit.edu	37	19	52724332	52724332	+	Silent	SNP	C	T	T			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr19:52724332C>T	uc002pyp.2	+	12	1623	c.1464C>T	c.(1462-1464)GCC>GCT	p.A488A	PPP2R1A_uc010ydk.1_Silent_p.A433A|PPP2R1A_uc002pyq.2_Silent_p.A309A	NM_014225	NP_055040	P30153	2AAA_HUMAN	alpha isoform of regulatory subunit A, protein	488	PP2A subunit C binding.|HEAT 13.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			endometrium(31)|ovary(28)|lung(2)|breast(2)|skin(1)|kidney(1)|pancreas(1)	66				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		AGGTCTTGGCCATGTCCGGAG	0.572000			Mis		clear cell ovarian carcinoma								3	88					0	0	0.004672	0	0
GTF3C3	9330	broad.mit.edu	37	2	197657782	197657782	+	Silent	SNP	C	T	T			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr2:197657782C>T	uc002uts.2	-	3	399	c.309G>A	c.(307-309)GAG>GAA	p.E103E	GTF3C3_uc010zgu.1_Silent_p.E103E|GTF3C3_uc002utu.2_Silent_p.E103E	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	103	Glu-rich.					transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7						cctcctcctcctcttcttcct	0.343000													3	40					0	0	0.004672	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								30	60					0	0	0.008740	0	0
TOP3B	8940	broad.mit.edu	37	22	22322990	22322990	+	Splice_Site	SNP	C	A	A			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr22:22322990C>A	uc002zvs.2	-	7	1173	c.738_splice	c.e7+1	p.K246_splice	TOP3B_uc010gtm.1_5'Flank|TOP3B_uc002zvr.2_Intron|TOP3B_uc010gtl.2_Splice_Site_p.K246_splice|TOP3B_uc002zvt.3_Splice_Site_p.K246_splice	NM_003935	NP_003926	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta						DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			kidney(1)	1	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		AGGCAAGGAACCTTGGCCTGC	0.552000													19	58					5.26018e-13	5.90166e-13	0.012319	1	0
RASD2	23551	broad.mit.edu	37	22	35947956	35947956	+	Silent	SNP	C	T	T	rs144245051		TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr22:35947956C>T	uc003anx.2	+	3	883	c.678C>T	c.(676-678)GAC>GAT	p.D226D	RASD2_uc003any.2_Silent_p.D226D	NM_014310	NP_055125	Q96D21	RHES_HUMAN	RASD family, member 2 precursor	226	Interaction with GNB1, GNB2 and GNB3.				locomotory behavior|positive regulation of protein kinase B signaling cascade|positive regulation of protein sumoylation|regulation of cAMP-mediated signaling	intracellular|plasma membrane	G-protein beta-subunit binding|GTP binding|GTPase activity			lung(2)|skin(1)	3						AGGAGATGGACGCCTATGGCA	0.642000													21	44					0	0	0.014323	0	0
TIGIT	201633	broad.mit.edu	37	3	114026861	114026861	+	Silent	SNP	A	G	G			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr3:114026861A>G	uc003ebg.1	+	4	652	c.618A>G	c.(616-618)GCA>GCG	p.A206A		NM_173799	NP_776160	Q495A1	TIGIT_HUMAN	T cell immunoreceptor with Ig and ITIM domains	206	Cytoplasmic (Potential).				negative regulation of interleukin-12 production|negative regulation of T cell activation|positive regulation of interleukin-10 production	cell surface|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)	1						CAGAAGCTGCACCTGCTGGGC	0.572000													42	83					0	0	0.014410	0	0
ZBTB20	26137	broad.mit.edu	37	3	114058211	114058211	+	Missense_Mutation	SNP	T	G	G			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr3:114058211T>G	uc003ebi.2	-	5	2047	c.1867A>C	c.(1867-1869)AAG>CAG	p.K623Q	ZBTB20_uc003ebj.2_Missense_Mutation_p.K550Q|ZBTB20_uc010hqp.2_Missense_Mutation_p.K550Q|ZBTB20_uc003ebk.2_Missense_Mutation_p.K550Q|ZBTB20_uc003ebl.2_Missense_Mutation_p.K550Q|ZBTB20_uc003ebm.2_Missense_Mutation_p.K550Q|ZBTB20_uc003ebn.2_Missense_Mutation_p.K550Q	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	623	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.P623T(1)		ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		ACCATGTGCTTGATAAGGTAA	0.527000													4	96					0	0	0.014758	0	0
MUC13	56667	broad.mit.edu	37	3	124632003	124632003	+	Missense_Mutation	SNP	G	A	A	rs148368651		TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr3:124632003G>A	uc003ehq.1	-	8	1190	c.1166C>T	c.(1165-1167)GCG>GTG	p.A389V		NM_033049	NP_149038	Q9H3R2	MUC13_HUMAN	mucin 13, epithelial transmembrane	389	EGF-like 3.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane					0						GGGCACGCACGCACACTCAGG	0.478000													3	54					0	0	0.004672	0	0
SDHAP1	255812	broad.mit.edu	37	3	195701278	195701278	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr3:195701278C>T	uc011btq.1	-	8	1215	c.586G>A	c.(586-588)GTG>ATG	p.V196M	SDHAP1_uc003fvx.3_RNA|SDHAP1_uc011btp.1_RNA					SubName: Full=cDNA FLJ56858, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						CAGGCCTGCACGACTCTGCGA	0.537000													3	28					0	0	0.001168	0	0
OTOP1	133060	broad.mit.edu	37	4	4199681	4199681	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr4:4199681G>A	uc003ghp.1	-	5	910	c.880C>T	c.(880-882)CGC>TGC	p.R294C		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	294					biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TCAACTTTGCGCCCGATGTTC	0.567000													29	71					0	0	0.021022	0	0
SLC34A2	10568	broad.mit.edu	37	4	25677957	25677957	+	Silent	SNP	G	A	A			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr4:25677957G>A	uc003grr.2	+	13	1740	c.1659G>A	c.(1657-1659)CGG>CGA	p.R553R	SLC34A2_uc003grs.2_Silent_p.R552R|SLC34A2_uc010iev.2_Silent_p.R552R	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	553	Helical; Name=M8; (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				CCGGCTGGCGGGTGCTGGTTG	0.597000													6	144					0	0	0.001984	0	0
PIK3R1	5295	broad.mit.edu	37	5	67591097	67591097	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr5:67591097A>G	uc003jva.2	+	13	2250	c.1690A>G	c.(1690-1692)AAC>GAC	p.N564D	PIK3R1_uc003jvb.2_Missense_Mutation_p.N564D|PIK3R1_uc003jvc.2_Missense_Mutation_p.N264D|PIK3R1_uc003jvd.2_Missense_Mutation_p.N294D|PIK3R1_uc003jve.2_Missense_Mutation_p.N243D|PIK3R1_uc011crb.1_Missense_Mutation_p.N234D	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	564					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.N564D(3)|p.D560_S565del(1)|p.N564K(1)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CAAACGTATGAACAGCATTAA	0.373000			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			3	104					0	0	0.009096	0	0
MAP1B	4131	broad.mit.edu	37	5	71490721	71490721	+	Missense_Mutation	SNP	G	T	T			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr5:71490721G>T	uc003kbw.3	+	5	1780	c.1539G>T	c.(1537-1539)CAG>CAT	p.Q513H	MAP1B_uc010iyw.1_Missense_Mutation_p.Q530H|MAP1B_uc010iyx.1_Missense_Mutation_p.Q387H|MAP1B_uc010iyy.1_Missense_Mutation_p.Q387H	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	513						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TTCTGAAGCAGCCACTGGCCA	0.507000													3	59					0.004672	0.00499795	0.004672	1	0
LYPLA2P1	653639	broad.mit.edu	37	6	33333333	33333333	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr6:33333333G>A	uc003shx.2	-	1	807	c.673C>T	c.(673-675)CCT>TCT	p.P225S		NR_001444				SubName: Full=Lysophospholipase II; Flags: Fragment;												0						AGTTAGACAGGAGGCAGCAGC	0.577000													3	21					0	0	0.009096	0	0
IL17F	112744	broad.mit.edu	37	6	52103580	52103580	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr6:52103580C>T	uc003pam.1	-	2	273	c.202G>A	c.(202-204)GTT>ATT	p.V68I	IL17F_uc003pal.1_Missense_Mutation_p.V14I	NM_052872	NP_443104	Q96PD4	IL17F_HUMAN	interleukin 17F precursor	68					cartilage development|inflammatory response|lymphotoxin A biosynthetic process|negative regulation of angiogenesis|proteoglycan metabolic process|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|regulation of interleukin-2 biosynthetic process|regulation of interleukin-6 biosynthetic process|regulation of interleukin-8 biosynthetic process|regulation of transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|cytokine binding|protein homodimerization activity			ovary(1)	1	Lung NSC(77;0.116)					GACATGGAAACGCGCTGGTTT	0.448000													26	39					0	0	0.015359	0	0
MCART3P	442229	broad.mit.edu	37	6	66498719	66498719	+	RNA	SNP	C	T	T			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr6:66498719C>T	uc011dxw.1	+	1		c.948C>T				NR_026540				Homo sapiens mitochondrial carrier triple repeat 3 pseudogene, mRNA (cDNA clone IMAGE:4821649).												0						TTCACTCCACCGGAAATAGTT	0.473000													7	57					0	0	0.001984	0	0
PTPRK	5796	broad.mit.edu	37	6	128297888	128297888	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr6:128297888A>G	uc003qbk.2	-	27	4247	c.3880T>C	c.(3880-3882)TAT>CAT	p.Y1294H	PTPRK_uc003qbj.2_Missense_Mutation_p.Y1295H|PTPRK_uc010kfc.2_Missense_Mutation_p.Y1301H|PTPRK_uc011ebu.1_Missense_Mutation_p.Y1317H	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1294	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity	p.R1294Q(1)		ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		ATGGGGCCATATCGTAGCATC	0.398000													3	63					0	0	0.009096	0	0
AP1S1	1174	broad.mit.edu	37	7	100799992	100799992	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr7:100799992G>C	uc003uxv.3	+	2	231	c.121G>C	c.(121-123)GCT>CCT	p.A41P		NM_001283	NP_001274	P61966	AP1S1_HUMAN	adaptor-related protein complex 1, sigma 1	41					intracellular protein transport|post-Golgi vesicle-mediated transport|receptor-mediated endocytosis|regulation of defense response to virus by virus|response to virus|viral reproduction	AP-1 adaptor complex|coated pit|cytosol|lysosomal membrane	protein binding|protein transporter activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)					GGTTGTCCTGGCTCGAAAGCC	0.537000													4	17					0	0	0.014758	0	0
CACNA1F	778	broad.mit.edu	37	X	49063294	49063294	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chrX:49063294C>T	uc004dnb.2	-	45	5349	c.5287G>A	c.(5287-5289)GCA>ACA	p.A1763T	CACNA1F_uc010nip.2_Missense_Mutation_p.A1752T	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	1763	Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	GGAGTCCCTGCCTGCTCATCT	0.637000													3	37					0	0	0.009096	0	0
FUBP1	8880	broad.mit.edu	37	1	78422268	78422269	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr1:78422268_78422269insT	uc001dii.2	-	17	1782_1783	c.1693_1694insA	c.(1693-1695)ACTfs	p.T565fs	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Frame_Shift_Ins_p.T586fs	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	565					transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						TTGTCCATTAGTTTGAGTTGTA	0.406													54	42	---	---	---	---					
PRIM1	5557	broad.mit.edu	37	12	57136804	57136804	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr12:57136804delT	uc001smd.2	-	7	779	c.715delA	c.(715-717)AGCfs	p.S239fs	PRIM1_uc001sme.1_RNA|PRIM1_uc009zoz.1_RNA	NM_000946	NP_000937	P49642	PRI1_HUMAN	DNA primase polypeptide 1	239					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	DNA primase activity|metal ion binding				0						TTATCCCAGCTTTCTTTATTT	0.299													2	4	---	---	---	---					
BTBD1	53339	broad.mit.edu	37	15	83687454	83687457	+	Splice_Site	DEL	CTTA	-	-			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr15:83687454_83687457delCTTA	uc002bjn.2	-	7	1493	c.1290_splice	c.e7+1	p.K430_splice	BTBD1_uc002bjo.2_Splice_Site	NM_025238	NP_079514	Q9H0C5	BTBD1_HUMAN	BTB (POZ) domain containing 1 isoform 1							cytoplasmic mRNA processing body|protein complex	protein binding			ovary(1)|central_nervous_system(1)	2				all cancers(203;0.000186)		GTGCATGACTCTTACTTTGAGTGT	0.441													22	55	---	---	---	---					
OR7E24	26648	broad.mit.edu	37	19	9361740	9361741	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr19:9361740_9361741insT	uc002mlb.1	+	1	21_22	c.21_22insT	c.(19-24)CTCTTTfs	p.L7fs		NM_001079935	NP_001073404	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E,	7_8	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TTCCAATTCTCTTTTTTTTTTT	0.386													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	19	12305944	12305944	+	RNA	DEL	G	-	-			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr19:12305944delG	uc002mtk.1	+	1		c.92delG			uc010dyq.1_RNA|uc002mtj.1_RNA					Homo sapiens cDNA FLJ13242 fis, clone OVARC1000578.																		CCAGACACCTGGAAGCCGGAA	0.637													6	5	---	---	---	---					
CIC	23152	broad.mit.edu	37	19	42792020	42792021	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr19:42792020_42792021delAG	uc002otf.1	+	6	864_865	c.824_825delAG	c.(823-825)AAGfs	p.K275fs		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	275					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				AAGGACCGAAAGAAGTCCAGCT	0.649			T	DUX4	soft tissue sarcoma								5	5	---	---	---	---					
BIRC6	57448	broad.mit.edu	37	2	32706407	32706407	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr2:32706407delT	uc010ezu.2	+	38	7562	c.7428delT	c.(7426-7428)TCTfs	p.S2476fs		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	2476					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CTCTGTCCTCTTTGGAAAAAG	0.333													10	105	---	---	---	---					
HCG4	54435	broad.mit.edu	37	6	29760353	29760373	+	RNA	DEL	GCGGGCGCCGTGGATGGAGCA	-	-	rs146714150		TCGA-HT-7608-01A-11D-2086-08	TCGA-HT-7608-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	89a5c656-38cc-4852-ac49-3a7ca6d164a0	1284b1b6-b9f7-4ee6-9ae2-f7da19f9deb6	g.chr6:29760353_29760373delGCGGGCGCCGTGGATGGAGCA	uc003nns.2	-	1		c.478_498delTGCTCCATCCACGGCGCCCGC			uc010jrm.1_In_Frame_Del_p.AGAVDGA111del|uc003nnt.2_In_Frame_Del_p.RAPWMEQ147del|uc011dma.1_5'Flank	NR_002139				Homo sapiens clone HCG IV.9 unknown mRNA.												0						GGATGGAGCCGCGGGCGCCGTGGATGGAGCAGGAGGGGCCG	0.674													5	3	---	---	---	---					
