Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CYP4Z2P	163720	broad.mit.edu	37	1	47325284	47325284	+	RNA	SNP	A	G	G			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr1:47325284A>G	uc001cqo.1	-	9		c.1284T>C				NR_002788				Homo sapiens cDNA FLJ40054 fis, clone TBAES2000315, weakly similar to CYTOCHROME P450 4A1 (EC 1.14.15.3).												0						TTCAATCCAAACATAGCTGCA	0.393													2	12					0	0	0.004672	0	0
NPR1	4881	broad.mit.edu	37	1	153654206	153654206	+	Silent	SNP	C	T	T	rs148390726		TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr1:153654206C>T	uc001fcs.3	+	4	1483	c.1062C>T	c.(1060-1062)CAC>CAT	p.H354H	NPR1_uc010pdz.1_Silent_p.H100H	NM_000906	NP_000897	P16066	ANPRA_HUMAN	natriuretic peptide receptor 1 precursor	354	Extracellular (Potential).				body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			ovary(3)|lung(2)|stomach(1)|breast(1)	7	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	CATCCTTCCACGACGGGCTCC	0.582													6	99					0	0	0.001984	0	0
TNNI1	7135	broad.mit.edu	37	1	201382170	201382170	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr1:201382170T>C	uc010ppq.1	-	6	362	c.269A>G	c.(268-270)AAC>AGC	p.N90S	TNNI1_uc001gwo.1_RNA|TNNI1_uc001gwp.2_Missense_Mutation_p.N69S	NM_003281	NP_003272	P19237	TNNI1_HUMAN	troponin I, skeletal, slow	90					muscle filament sliding|regulation of striated muscle contraction	cytosol|troponin complex	actin binding|tropomyosin binding				0						CTCCCTGGTGTTGTGGAGGCA	0.622													18	396					0	0	0.014323	0	0
PCBP2	5094	broad.mit.edu	37	12	53865444	53865444	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr12:53865444G>A	uc001sdl.3	+	14	1264	c.914G>A	c.(913-915)CGT>CAT	p.R305H	PCBP2_uc001sdc.3_Missense_Mutation_p.R306H|PCBP2_uc001sdb.3_Missense_Mutation_p.R302H|PCBP2_uc001sde.3_Missense_Mutation_p.R301H|PCBP2_uc001sdi.3_Missense_Mutation_p.R275H|PCBP2_uc001sdd.3_Missense_Mutation_p.R271H|PCBP2_uc001sdf.3_Missense_Mutation_p.R258H|PCBP2_uc009zna.2_Missense_Mutation_p.R263H|PCBP2_uc010soi.1_Missense_Mutation_p.R43H|PCBP2_uc001sdj.3_Missense_Mutation_p.R56H|PCBP2_uc010soj.1_Missense_Mutation_p.R55H|PCBP2_uc001sdk.3_Missense_Mutation_p.R78H	NM_001128911	NP_001122383	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2 isoform d	305	KH 3.				innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding				0						ATAATCGGGCGTCAAGGCGCC	0.498													5	37					0	0	0.001168	0	0
LRP1	4035	broad.mit.edu	37	12	57601869	57601869	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr12:57601869G>A	uc001snd.2	+	77	12374	c.11908G>A	c.(11908-11910)GGA>AGA	p.G3970R		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	3970	LDL-receptor class B 32.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CTGGGTGGCCGGAAACGTGTA	0.577													22	32					0	0	0.021523	0	0
C12orf63	374467	broad.mit.edu	37	12	97136314	97136314	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr12:97136314C>A	uc001tet.1	+	19	2522	c.2444C>A	c.(2443-2445)GCA>GAA	p.A815E		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	815										skin(6)|ovary(1)	7						TGCCGCTTAGCATTGGTGACT	0.348													14	20					6.31663e-08	7.27785e-08	0.003163	1	0
ATP12A	479	broad.mit.edu	37	13	25275010	25275010	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr13:25275010C>T	uc001upp.2	+	13	2018	c.1831C>T	c.(1831-1833)CGG>TGG	p.R611W	ATP12A_uc010aaa.2_Missense_Mutation_p.R617W	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	611	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CGATCCCCCTCGGTCCACCGT	0.483													5	93					0	0	0.014758	0	0
ATG2B	55102	broad.mit.edu	37	14	96798962	96798962	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr14:96798962A>G	uc001yfi.2	-	9	1603	c.1238T>C	c.(1237-1239)ATG>ACG	p.M413T		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	413										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		AGACATGTCCATATCAGCCAT	0.378													7	63					0	0	0.003080	0	0
TTC23	64927	broad.mit.edu	37	15	99678265	99678265	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr15:99678265G>A	uc002bur.2	-	13	1825	c.1294C>T	c.(1294-1296)CCT>TCT	p.P432S	TTC23_uc002bus.2_Missense_Mutation_p.P432S|TTC23_uc002but.2_Missense_Mutation_p.P432S|TTC23_uc002buu.2_Missense_Mutation_p.P432S|TTC23_uc002buv.2_Missense_Mutation_p.P432S|TTC23_uc002bux.2_Missense_Mutation_p.P432S|TTC23_uc002buw.2_Missense_Mutation_p.P432S|TTC23_uc010boq.2_RNA|TTC23_uc002buy.2_Missense_Mutation_p.P432S|TTC23_uc010bor.2_Missense_Mutation_p.P432S	NM_022905	NP_075056	Q5W5X9	TTC23_HUMAN	tetratricopeptide repeat domain 23	432							binding				0	all_cancers(4;1.49e-13)|Lung NSC(78;0.000545)|all_lung(78;0.00121)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		all cancers(5;8.11e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00215)			GTGTCCTGAGGGATGCTGGTG	0.607													5	46					0	0	0.014758	0	0
AMFR	267	broad.mit.edu	37	16	56423219	56423219	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr16:56423219G>A	uc002eiy.2	-	9	1359	c.1154C>T	c.(1153-1155)GCC>GTC	p.A385V	AMFR_uc002eix.2_Intron	NM_001144	NP_001135	Q9UKV5	AMFR2_HUMAN	autocrine motility factor receptor	385					endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein oligomerization|protein polyubiquitination	integral to endoplasmic reticulum membrane|integral to membrane of membrane fraction	protein binding|protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)	2						ATTATTGTCGGCAATATTAAG	0.463													4	110					0	0	0.014758	0	0
TP53	7157	broad.mit.edu	37	17	7577120	7577120	+	Missense_Mutation	SNP	C	T	T	rs28934576	by1000genomes	TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr17:7577120C>T	uc002gim.2	-	8	1012	c.818G>A	c.(817-819)CGT>CAT	p.R273H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141H|TP53_uc010cng.1_Missense_Mutation_p.R141H|TP53_uc002gii.1_Missense_Mutation_p.R141H|TP53_uc010cnh.1_Missense_Mutation_p.R273H|TP53_uc010cni.1_Missense_Mutation_p.R273H|TP53_uc002gij.2_Missense_Mutation_p.R273H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	11					0	0	0.013537	0	0
TP53	7157	broad.mit.edu	37	17	7578176	7578176	+	Splice_Site	SNP	C	T	T			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr17:7578176C>T	uc002gim.2	-	6	866	c.672_splice	c.e6+1	p.E224_splice	TP53_uc002gig.1_Splice_Site_p.E224_splice|TP53_uc002gih.2_Splice_Site_p.E224_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Splice_Site_p.E92_splice|TP53_uc010cng.1_Splice_Site_p.E92_splice|TP53_uc002gii.1_Splice_Site_p.E92_splice|TP53_uc010cnh.1_Splice_Site_p.E224_splice|TP53_uc010cni.1_Splice_Site_p.E224_splice|TP53_uc002gij.2_Splice_Site_p.E224_splice|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Splice_Site_p.E131_splice|TP53_uc002gio.2_Splice_Site_p.E92_splice|TP53_uc010vug.1_Missense_Mutation_p.V186I	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(26)|p.0?(7)|p.V225fs*24(1)|p.E224_V225insXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAAACCAGACCTCAGGCGGC	0.517		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	22					0	0	0.004007	0	0
WDR16	146845	broad.mit.edu	37	17	9546433	9546433	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr17:9546433G>A	uc002gly.2	+	14	1850	c.1781G>A	c.(1780-1782)CGC>CAC	p.R594H	USP43_uc002gma.3_5'Flank|USP43_uc010cod.2_5'Flank|USP43_uc010vva.1_5'Flank|WDR16_uc002glz.2_Missense_Mutation_p.R526H|WDR16_uc010coc.2_Missense_Mutation_p.R604H	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	594	WD 11.					cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						ACACGCATCCGCATAAGTCCA	0.453													3	69					0	0	0.009096	0	0
FLJ36000	284124	broad.mit.edu	37	17	21904125	21904125	+	RNA	SNP	G	A	A			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr17:21904125G>A	uc002gza.2	+	1		c.64G>A				NR_027084				Homo sapiens cDNA FLJ36000 fis, clone TESTI2015180.												0						ggagtcgcaaggggccgagca	0													7	106					0	0	0.001984	0	0
KRT26	353288	broad.mit.edu	37	17	38926339	38926339	+	Silent	SNP	G	A	A			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr17:38926339G>A	uc002hvf.2	-	4	763	c.717C>T	c.(715-717)AAC>AAT	p.N239N		NM_181539	NP_853517	Q7Z3Y9	K1C26_HUMAN	keratin 26	239	Rod.|Linker 12.					intermediate filament	structural molecule activity				0		Breast(137;0.00526)				CCACGTTCACGTTCCCCCCAG	0.488													61	61					0	0	0.014410	0	0
Unknown	0	broad.mit.edu	37	17	45105705	45105705	+	RNA	SNP	A	G	G	rs147936028	by1000genomes	TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr17:45105705A>G	uc010wki.1	+	5		c.1307A>G								Homo sapiens cDNA FLJ42521 fis, clone BRACE3000973.																		GCCTGGCACGAAATGCAGTTT	0.303													3	85					0	0	0.004672	0	0
POU2F2	5452	broad.mit.edu	37	19	42600387	42600387	+	Silent	SNP	G	A	A			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr19:42600387G>A	uc002osp.2	-	8	577	c.510C>T	c.(508-510)ACC>ACT	p.T170T	POU2F2_uc002osn.2_Intron|POU2F2_uc002oso.2_5'UTR|POU2F2_uc002osq.2_Intron|POU2F2_uc002osr.1_Silent_p.T170T	NM_002698	NP_002689	P09086	PO2F2_HUMAN	POU domain, class 2, transcription factor 2	170					humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2		Prostate(69;0.059)				GCGTAGGGCGGGTCACGGCCT	0.711													3	11					0	0	0.004672	0	0
MYH14	79784	broad.mit.edu	37	19	50720927	50720927	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr19:50720927A>G	uc002prr.1	+	3	508	c.461A>G	c.(460-462)TAC>TGC	p.Y154C	MYH14_uc010enu.1_Missense_Mutation_p.Y154C|MYH14_uc002prq.1_Missense_Mutation_p.Y154C	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	154	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CTTCCCATCTACACAGAAGCC	0.607													53	73					0	0	0.014410	0	0
TFCP2L1	29842	broad.mit.edu	37	2	121991692	121991692	+	Silent	SNP	G	A	A	rs140466557	by1000genomes	TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr2:121991692G>A	uc002tmx.2	-	12	1266	c.1173C>T	c.(1171-1173)GAC>GAT	p.D391D	TFCP2L1_uc010flr.2_Silent_p.D391D|TFCP2L1_uc010flq.2_RNA	NM_014553	NP_055368	Q9NZI6	TF2L1_HUMAN	LBP-9	391					female pregnancy|steroid biosynthetic process	mitochondrion|nucleolus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			pancreas(2)|ovary(1)	3	Renal(3;0.01)					CTCCACTGCCGTCCCGCTTCT	0.572													14	119					0	0	0.003163	0	0
HOXD11	3237	broad.mit.edu	37	2	176973690	176973690	+	Silent	SNP	C	T	T			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr2:176973690C>T	uc002uki.2	+	2	837	c.837C>T	c.(835-837)CGC>CGT	p.R279R	HOXD11_uc010fqx.2_RNA	NM_021192	NP_067015	P31277	HXD11_HUMAN	homeobox D11	279	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0521)|READ - Rectum adenocarcinoma(9;0.0678)		ACCAGATCCGCGAACTGGAAC	0.522			T	NUP98	AML								4	149					0	0	0.014758	0	0
FKBP7	51661	broad.mit.edu	37	2	179341854	179341854	+	Missense_Mutation	SNP	A	G	G	rs144779588		TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr2:179341854A>G	uc002umk.2	-	2	437	c.308T>C	c.(307-309)ATG>ACG	p.M103T	FKBP7_uc002umm.2_Missense_Mutation_p.M103T|FKBP7_uc002uml.2_RNA|FKBP7_uc010zff.1_Missense_Mutation_p.M99T	NM_181342	NP_851939	Q9Y680	FKBP7_HUMAN	FK506 binding protein 7 isoform a precursor	103	PPIase FKBP-type.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.0159)|all cancers(119;0.0564)			TCCAGGGCACATATCTGTCAT	0.393													41	63					0	0	0.014410	0	0
NCKAP1	10787	broad.mit.edu	37	2	183829476	183829476	+	Silent	SNP	T	C	C			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr2:183829476T>C	uc002upc.2	-	17	2091	c.1689A>G	c.(1687-1689)TCA>TCG	p.S563S	NCKAP1_uc002upb.2_Silent_p.S569S	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	563					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TTGAGTATCTTGATTGAGAGG	0.323													6	79					0	0	0.003080	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 								35	48					0	0	0.008740	0	0
KLHL30	377007	broad.mit.edu	37	2	239059501	239059501	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr2:239059501T>C	uc002vxr.1	+	7	1511	c.1478T>C	c.(1477-1479)CTG>CCG	p.L493P		NM_198582	NP_940984	Q0D2K2	KLH30_HUMAN	kelch-like 30	511	Kelch 5.										0		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		CTGGTGCCACTGGGTGATGCG	0.662													5	9					0	0	0.014758	0	0
SLC34A2	10568	broad.mit.edu	37	4	25677849	25677849	+	Silent	SNP	G	A	A			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr4:25677849G>A	uc003grr.2	+	13	1632	c.1551G>A	c.(1549-1551)GGG>GGA	p.G517G	SLC34A2_uc003grs.2_Silent_p.G516G|SLC34A2_uc010iev.2_Silent_p.G516G	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	517	Cytoplasmic (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				TGGCCAAGGGGCTGGGCAACA	0.577													68	94					0	0	0.014410	0	0
OTUD4	54726	broad.mit.edu	37	4	146059006	146059006	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr4:146059006G>A	uc003ika.3	-	21	2864	c.2726C>T	c.(2725-2727)ACT>ATT	p.T909I	OTUD4_uc003ijz.3_Missense_Mutation_p.T908I	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	973							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					AACAGGCACAGTTTCTCTCTC	0.463													5	171					0	0	0.001984	0	0
OTUD4	54726	broad.mit.edu	37	4	146059041	146059041	+	Silent	SNP	A	G	G			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr4:146059041A>G	uc003ika.3	-	21	2829	c.2691T>C	c.(2689-2691)CAT>CAC	p.H897H	OTUD4_uc003ijz.3_Silent_p.H896H	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	961							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					GAGTGGGAGGATGAGCCTTTC	0.478													4	145					0	0	0.014758	0	0
MCCC2	64087	broad.mit.edu	37	5	70944989	70944989	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr5:70944989G>A	uc003kbs.3	+	14	1420	c.1282G>A	c.(1282-1284)GCT>ACT	p.A428T	MCCC2_uc003kbt.3_RNA	NM_022132	NP_071415	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	428	Carboxyltransferase.				leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)	1		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	GATGGTGGCCGCTGTGGCCTG	0.512													3	60					0	0	0.004672	0	0
SSBP2	23635	broad.mit.edu	37	5	80785076	80785076	+	Missense_Mutation	SNP	G	T	T			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr5:80785076G>T	uc003kho.2	-	6	636	c.425C>A	c.(424-426)CCT>CAT	p.P142H	SSBP2_uc010jar.2_Missense_Mutation_p.P30H|SSBP2_uc003khn.2_Missense_Mutation_p.P16H|SSBP2_uc003khp.2_Missense_Mutation_p.P142H|SSBP2_uc011ctp.1_Intron|SSBP2_uc011ctq.1_Missense_Mutation_p.P112H|SSBP2_uc011ctr.1_Missense_Mutation_p.P112H	NM_012446	NP_036578	P81877	SSBP2_HUMAN	single-stranded DNA binding protein 2	142	Pro-rich.				regulation of transcription, DNA-dependent	cytoplasm|nucleus	single-stranded DNA binding		SSBP2/JAK2(4)	haematopoietic_and_lymphoid_tissue(4)|skin(1)	5		Lung NSC(167;0.00154)|all_lung(232;0.00179)|Ovarian(174;0.0338)		OV - Ovarian serous cystadenocarcinoma(54;1.07e-41)|Epithelial(54;2.79e-35)|all cancers(79;1.18e-29)		TACCTGATTAGGTATCCTCAA	0.328													6	28					5.9392e-07	6.6974e-07	0.001168	1	0
PJA2	9867	broad.mit.edu	37	5	108717302	108717302	+	Missense_Mutation	SNP	A	C	C			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr5:108717302A>C	uc003kos.3	-	3	354	c.134T>G	c.(133-135)TTT>TGT	p.F45C		NM_014819	NP_055634	O43164	PJA2_HUMAN	praja 2, RING-H2 motif containing	45					long-term memory|regulation of protein kinase A signaling cascade	cell junction|endoplasmic reticulum membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	ligase activity|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(142;4.4e-06)|all_epithelial(76;8.17e-08)|Prostate(80;0.00676)|Lung NSC(167;0.0436)|Ovarian(225;0.0443)|all_lung(232;0.053)|Colorectal(57;0.0946)|Breast(839;0.151)		OV - Ovarian serous cystadenocarcinoma(64;3.46e-10)|Epithelial(69;6.02e-09)|COAD - Colon adenocarcinoma(37;0.224)		ACATGGTTTAAAACTGACATA	0.443													9	76					0	0	0.004482	0	0
FTMT	94033	broad.mit.edu	37	5	121188111	121188111	+	Silent	SNP	C	T	T			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr5:121188111C>T	uc003kss.2	+	1	462	c.453C>T	c.(451-453)GAC>GAT	p.D151D		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial precursor	151	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		CGGAACAGGACGACTGGGAAA	0.582													11	114					0	0	0.013537	0	0
PCDHB3	56132	broad.mit.edu	37	5	140482147	140482147	+	Missense_Mutation	SNP	C	G	G	rs144773246	byFrequency	TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr5:140482147C>G	uc003lio.2	+	1	1914	c.1914C>G	c.(1912-1914)CAC>CAG	p.H638Q	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	638	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGGCCAAGCACAGGCTGGTGG	0.697													4	109					0	0	0.001168	0	0
CCDC69	26112	broad.mit.edu	37	5	150565607	150565607	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr5:150565607G>A	uc003ltq.2	-	6	595	c.472C>T	c.(472-474)CGA>TGA	p.R158*	CCDC69_uc010jhu.2_Nonsense_Mutation_p.R11*|CCDC69_uc011dcq.1_RNA	NM_015621	NP_056436	A6NI79	CCD69_HUMAN	coiled-coil domain containing 69	158	Potential.									ovary(2)	2		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTATAGTTTCGGCTCAGAATG	0.557													10	102					0	0	0.013537	0	0
GRIK2	2898	broad.mit.edu	37	6	102372528	102372528	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr6:102372528G>A	uc003pqp.3	+	12	2050	c.1801G>A	c.(1801-1803)GTG>ATG	p.V601M	GRIK2_uc003pqo.3_Missense_Mutation_p.V601M|GRIK2_uc010kcw.2_Missense_Mutation_p.V601M	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	601	Cytoplasmic (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TGACTCAGACGTGGTGGAAAA	0.418													9	102					0	0	0.010729	0	0
DOCK4	9732	broad.mit.edu	37	7	111624387	111624387	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr7:111624387T>C	uc003vfx.2	-	7	792	c.523A>G	c.(523-525)ATC>GTC	p.I175V	DOCK4_uc003vfy.2_Missense_Mutation_p.I175V|DOCK4_uc003vga.1_5'UTR|DOCK4_uc010ljt.1_Missense_Mutation_p.I175V|DOCK4_uc003vgb.1_Missense_Mutation_p.I99V	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	175					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				GTAATGCTGATGTCTTCCGGA	0.463													7	15					0	0	0.006214	0	0
UBN2	254048	broad.mit.edu	37	7	138969195	138969195	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr7:138969195G>A	uc011kqr.1	+	15	3544	c.3544G>A	c.(3544-3546)GGA>AGA	p.G1182R		NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	1182	Ser-rich.									ovary(1)|skin(1)	2						TAACTCAAGCGGAGCTAATAG	0.493													3	95					0	0	0.009096	0	0
DLGAP2	9228	broad.mit.edu	37	8	1626416	1626416	+	Silent	SNP	C	T	T			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr8:1626416C>T	uc003wpl.2	+	9	2182	c.2085C>T	c.(2083-2085)GCC>GCT	p.A695A	DLGAP2_uc003wpm.2_Silent_p.A681A	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	774					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		GCGTCACGGCCGCCGTCCAAG	0.572													3	73					0	0	0.004672	0	0
CSMD3	114788	broad.mit.edu	37	8	113504737	113504737	+	Silent	SNP	T	C	C			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr8:113504737T>C	uc003ynu.2	-	31	5418	c.5259A>G	c.(5257-5259)AGA>AGG	p.R1753R	CSMD3_uc003yns.2_Silent_p.R1025R|CSMD3_uc003ynt.2_Silent_p.R1713R|CSMD3_uc011lhx.1_Silent_p.R1649R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1753	Extracellular (Potential).|Sushi 9.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTGGCAAGGCTCTATTCCATC	0.363										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			9	105					0	0	0.006214	0	0
GRINA	2907	broad.mit.edu	37	8	145066754	145066754	+	Missense_Mutation	SNP	T	A	A			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr8:145066754T>A	uc003zan.1	+	6	1110	c.944T>A	c.(943-945)CTG>CAG	p.L315Q	GRINA_uc003zao.1_Missense_Mutation_p.L315Q|GRINA_uc003zap.1_Missense_Mutation_p.L315Q	NM_001009184	NP_001009184	Q7Z429	GRINA_HUMAN	glutamate receptor, ionotropic, N-methyl	315	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TACGCCTCACTGGGCGCTCTG	0.617													20	37					0	0	0.018920	0	0
EIF1AX	1964	broad.mit.edu	37	X	20156729	20156729	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chrX:20156729T>C	uc004czt.2	-	2	236	c.28A>G	c.(28-30)AAA>GAA	p.K10E	SCARNA9L_uc010nfp.2_5'Flank	NM_001412	NP_001403	P47813	IF1AX_HUMAN	X-linked eukaryotic translation initiation	10						cytosol	translation initiation factor activity			ovary(1)	1						CGTCTGTTTTTACCTCCTTTA	0.308													36	4					0	0	0.005524	0	0
ITGB1BP2	26548	broad.mit.edu	37	X	70524875	70524875	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chrX:70524875G>A	uc004dzr.1	+	11	906	c.877G>A	c.(877-879)GTC>ATC	p.V293I	BCYRN1_uc011mpt.1_Intron|ITGB1BP2_uc004dzs.1_Missense_Mutation_p.V275I	NM_012278	NP_036410	Q9UKP3	ITBP2_HUMAN	integrin beta 1 binding protein 2	293	CS.				muscle organ development|signal transduction		SH3 domain binding			ovary(1)	1	Renal(35;0.156)					AATCTCCCTGGTCAAGGCTGA	0.517													17	19					0	0	0.004990	0	0
PCDH19	57526	broad.mit.edu	37	X	99661766	99661766	+	Silent	SNP	G	A	A			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chrX:99661766G>A	uc010nmz.2	-	1	3506	c.1830C>T	c.(1828-1830)GGC>GGT	p.G610G	PCDH19_uc004efw.3_Silent_p.G610G|PCDH19_uc004efx.3_Silent_p.G610G	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	610	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						AGCCGCGGTCGCCCTCGGTCA	0.562													3	33					0	0	0.009096	0	0
ODZ1	10178	broad.mit.edu	37	X	123519791	123519791	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chrX:123519791C>A	uc004euj.2	-	28	5855	c.5791G>T	c.(5791-5793)GGC>TGC	p.G1931C	ODZ1_uc011muj.1_Missense_Mutation_p.G1937C|ODZ1_uc010nqy.2_Missense_Mutation_p.G1938C	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1931	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CGGTAGTAGCCCACTGAAAGC	0.512													4	54					0.00909568	0.00983818	0.009096	1	0
OCRL	4952	broad.mit.edu	37	X	128710473	128710473	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chrX:128710473C>G	uc004euq.2	+	18	2224	c.2059C>G	c.(2059-2061)CTG>GTG	p.L687V	OCRL_uc004eur.2_Missense_Mutation_p.L687V	NM_000276	NP_000267	Q01968	OCRL_HUMAN	phosphatidylinositol polyphosphate 5-phosphatase	687					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			lung(2)|ovary(1)|kidney(1)	4						CTTAGAGGCTCTGTGCCGTAT	0.403													41	7					0	0	0.014410	0	0
SAGE1	55511	broad.mit.edu	37	X	134988660	134988660	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chrX:134988660G>A	uc004ezh.2	+	7	853	c.686G>A	c.(685-687)CGT>CAT	p.R229H	SAGE1_uc010nry.1_Missense_Mutation_p.R198H|SAGE1_uc011mvv.1_Intron	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	229										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CGACCACGGCGTATTAATATG	0.423													5	129					0	0	0.001168	0	0
WEE1	7465	broad.mit.edu	37	11	9595595	9595597	+	In_Frame_Del	DEL	GAG	-	-			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr11:9595595_9595597delGAG	uc001mhs.2	+	1	368_370	c.115_117delGAG	c.(115-117)GAGdel	p.E43del	WEE1_uc001mht.2_5'Flank|WEE1_uc001mhu.2_5'Flank	NM_003390	NP_003381	P30291	WEE1_HUMAN	WEE1 tyrosine kinase isoform 1	43	Poly-Glu.				blood coagulation|cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|S phase of mitotic cell cycle	nucleoplasm	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	5				all cancers(16;4.59e-09)|Epithelial(150;3.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0484)		ggaggaagaagaggaggaggagg	0.355													2	4	---	---	---	---					
CHD4	1108	broad.mit.edu	37	12	6711145	6711147	+	In_Frame_Del	DEL	TCC	-	-	rs1639122	byFrequency	TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr12:6711145_6711147delTCC	uc001qpo.2	-	4	581_583	c.417_419delGGA	c.(415-420)GAGGAT>GAT	p.E139del	CHD4_uc001qpn.2_In_Frame_Del_p.E132del|CHD4_uc001qpp.2_In_Frame_Del_p.E136del	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	139	Poly-Asp.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						ATCATCATCAtcctcctcctcct	0.384													8	58	---	---	---	---					
SH3BP1	23616	broad.mit.edu	37	22	38039752	38039754	+	In_Frame_Del	DEL	AGG	-	-			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr22:38039752_38039754delAGG	uc003ati.2	+	7	686_688	c.575_577delAGG	c.(574-579)AAGGAG>AAG	p.E197del	SH3BP1_uc003atg.1_RNA|SH3BP1_uc011anl.1_In_Frame_Del_p.E197del|SH3BP1_uc003ath.1_In_Frame_Del_p.E197del|SH3BP1_uc003atj.1_In_Frame_Del_p.E133del|SH3BP1_uc003atk.1_In_Frame_Del_p.E111del|uc003atl.1_RNA	NM_018957	NP_061830	Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1	197	BAR.				signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					GAGACGCTGAAGGAGGAGGAGGA	0.498											OREG0026546	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	127	---	---	---	---					
TIMD4	91937	broad.mit.edu	37	5	156378745	156378747	+	In_Frame_Del	DEL	TTG	-	-			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr5:156378745_156378747delTTG	uc003lwh.2	-	3	512_514	c.455_457delCAA	c.(454-459)ACAAGC>AGC	p.T152del	TIMD4_uc010jii.2_In_Frame_Del_p.T152del	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain	152	Extracellular (Potential).|Thr-rich.					integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTGGTGGGGCTTGTTGTTGTTGT	0.537													7	397	---	---	---	---					
MYO6	4646	broad.mit.edu	37	6	76599857	76599858	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chr6:76599857_76599858insA	uc003pih.1	+	26	3021_3022	c.2742_2743insA	c.(2740-2745)CAGAAAfs	p.Q914fs	MYO6_uc003pig.1_Frame_Shift_Ins_p.Q914fs|MYO6_uc003pii.1_Frame_Shift_Ins_p.Q914fs	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	914_915	Potential.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		GTGCATTACAGAAAAAAAAACA	0.381													9	84	---	---	---	---					
GPC3	2719	broad.mit.edu	37	X	133119384	133119386	+	In_Frame_Del	DEL	CGG	-	-			TCGA-HT-7609-01A-11D-2086-08	TCGA-HT-7609-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d5f5c7e-e359-4788-8718-f7fc5164a30d	8f0035fe-017d-4cf6-81b8-79b90a6214c5	g.chrX:133119384_133119386delCGG	uc004exe.1	-	1	281_283	c.91_93delCCG	c.(91-93)CCGdel	p.P31del	GPC3_uc010nrn.1_In_Frame_Del_p.P31del|GPC3_uc011mvh.1_In_Frame_Del_p.P31del|GPC3_uc010nro.1_In_Frame_Del_p.P31del|GPC3_uc010nrp.1_5'UTR	NM_004484	NP_004475	P51654	GPC3_HUMAN	glypican 3 isoform 2 precursor	31						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			lung(2)|prostate(1)|breast(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					AGGTGGCGTCCGGCGGCGGCGGC	0.690			T|D|Mis|N|F|S			Wilms tumour			Simpson-Golabi-Behmel_syndrome				3	6	---	---	---	---					
