Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CROCCL1	84809	broad.mit.edu	37	1	16946438	16946438	+	RNA	SNP	G	A	A	rs28392876	by1000genomes	TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr1:16946438G>A	uc010ocf.1	-	3		c.460C>T			CROCCL1_uc009vov.1_RNA|CROCCL1_uc001aze.2_RNA|CROCCL1_uc001azf.2_RNA					Homo sapiens mRNA for FLJ00313 protein.												0						GCCTTCCGCCGGGCCAGCAGC	0.672000													4	34					0	0	0.184627	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18808237	18808237	+	Silent	SNP	C	T	T			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr1:18808237C>T	uc001bax.2	+	1	814	c.762C>T	c.(760-762)GGC>GGT	p.G254G	KLHDC7A_uc009vpg.2_Silent_p.G36G	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	254						integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		AGCAGGAGGGCGCCCCCAACT	0.612000													6	138					0	0	0.248553	0	0
OR6N2	81442	broad.mit.edu	37	1	158747181	158747181	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr1:158747181A>G	uc010pir.1	-	1	245	c.245T>C	c.(244-246)TTG>TCG	p.L82S		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	82	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					AATATTAGACAACATCTTAGG	0.448000													9	149					0	0	0.387290	0	0
SELE	6401	broad.mit.edu	37	1	169699643	169699643	+	Silent	SNP	C	A	A			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr1:169699643C>A	uc001ggm.3	-	5	802	c.645G>T	c.(643-645)CTG>CTT	p.L215L	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	215	Sushi 1.|Extracellular (Potential).				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					TGCTGCTTGGCAGGTAACCCC	0.512000													5	130					2.7689e-08	2.90287e-08	0.248553	1	0
CACNB2	783	broad.mit.edu	37	10	18787332	18787332	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr10:18787332G>A	uc001ipr.2	+	4	442	c.382G>A	c.(382-384)GCC>ACC	p.A128T	CACNB2_uc009xjz.1_Missense_Mutation_p.A128T|CACNB2_uc001ips.2_Missense_Mutation_p.A128T|CACNB2_uc001ipt.2_Missense_Mutation_p.A128T|CACNB2_uc010qcl.1_RNA|CACNB2_uc001ipu.2_Missense_Mutation_p.A100T|CACNB2_uc001ipv.2_Missense_Mutation_p.A100T|CACNB2_uc009xka.1_Missense_Mutation_p.A100T|CACNB2_uc001ipw.2_Missense_Mutation_p.A73T|CACNB2_uc001ipx.2_Missense_Mutation_p.A73T|CACNB2_uc009xkb.1_Missense_Mutation_p.A74T|CACNB2_uc010qcm.1_Missense_Mutation_p.A74T|CACNB2_uc001ipz.2_Missense_Mutation_p.A74T|CACNB2_uc001ipy.2_Missense_Mutation_p.A74T|CACNB2_uc010qcn.1_Missense_Mutation_p.A80T|CACNB2_uc010qco.1_Missense_Mutation_p.A80T|CACNB2_uc001iqa.2_Missense_Mutation_p.A80T	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	128	SH3.				axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CTACAGTGCGGCCCATGAAGA	0.423000													4	81					0	0	0.150653	0	0
CD248	57124	broad.mit.edu	37	11	66084109	66084109	+	Silent	SNP	G	A	A			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr11:66084109G>A	uc001ohm.1	-	1	407	c.390C>T	c.(388-390)CGC>CGT	p.R130R		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	130	C-type lectin.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	GGGCCACACAGCGCTGGGCCG	0.701000													31	17					0	0	0.760397	0	0
FAM76B	143684	broad.mit.edu	37	11	95512812	95512812	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr11:95512812C>G	uc001pfn.2	-	7	963	c.651G>C	c.(649-651)AAG>AAC	p.K217N	FAM76B_uc001pfm.2_RNA	NM_144664	NP_653265	Q5HYJ3	FA76B_HUMAN	hypothetical protein LOC143684	217											0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TGGGCTTTTTCTTTGGAGTTT	0.308000													14	126					0	0	0.557998	0	0
MGAT4C	25834	broad.mit.edu	37	12	86373270	86373270	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr12:86373270C>G	uc001tai.3	-	8	2484	c.1234G>C	c.(1234-1236)GAT>CAT	p.D412H	MGAT4C_uc001tal.3_Missense_Mutation_p.D412H|MGAT4C_uc001taj.3_Missense_Mutation_p.D412H|MGAT4C_uc001tak.3_Missense_Mutation_p.D412H|MGAT4C_uc010sum.1_Missense_Mutation_p.D436H|MGAT4C_uc001tah.3_Missense_Mutation_p.D412H	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	412	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						TCCCCAACATCTAGGGCTCCA	0.318000													4	52					0	0	0.217242	0	0
SDR39U1	56948	broad.mit.edu	37	14	24909470	24909470	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr14:24909470G>A	uc001wpm.2	-	6	733	c.701C>T	c.(700-702)GCT>GTT	p.A234V	KHNYN_uc010tpc.1_3'UTR|KHNYN_uc001wph.3_3'UTR|KHNYN_uc010alw.2_3'UTR|SDR39U1_uc001wpi.2_Missense_Mutation_p.A126V|SDR39U1_uc001wpj.2_Missense_Mutation_p.A152V|SDR39U1_uc001wpk.2_Missense_Mutation_p.A126V|SDR39U1_uc001wpl.2_Missense_Mutation_p.A179V|SDR39U1_uc001wpn.2_Missense_Mutation_p.A109V|uc001wpo.1_5'Flank	NM_020195	NP_064580	Q9NRG7	D39U1_HUMAN	short chain dehydrogenase/reductase family 39U,	260							binding			pancreas(1)	1						GCCCAGGGCAGCACCCAAGGT	0.622000													3	54					0	0	0.150653	0	0
PNN	5411	broad.mit.edu	37	14	39648579	39648579	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr14:39648579A>G	uc001wuw.3	+	8	803	c.706A>G	c.(706-708)AAG>GAG	p.K236E		NM_002687	NP_002678	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	236	Necessary for interaction with RNPS1.|Glu-rich.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			ovary(1)	1	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		TATAAGAACTAAGACAAAGCC	0.338000													3	24					0	0	0.150653	0	0
TP53BP1	7158	broad.mit.edu	37	15	43701105	43701105	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr15:43701105T>C	uc001zrs.2	-	26	5723	c.5575A>G	c.(5575-5577)ATT>GTT	p.I1859V	TP53BP1_uc010udp.1_Missense_Mutation_p.I1857V|TP53BP1_uc001zrq.3_Missense_Mutation_p.I1862V|TP53BP1_uc001zrr.3_Missense_Mutation_p.I1864V|TP53BP1_uc001zrp.2_Missense_Mutation_p.I276V	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	1859					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		CAGTCCAGAATTCTTTGCTCC	0.473000								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					6	91					0	0	0.217242	0	0
SBK1	388228	broad.mit.edu	37	16	28331453	28331453	+	Silent	SNP	G	C	C			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr16:28331453G>C	uc002dpd.2	+	4	1275	c.486G>C	c.(484-486)CTG>CTC	p.L162L		NM_001024401	NP_001019572	Q52WX2	SBK1_HUMAN	SH3-binding kinase 1	162	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|kidney(1)	2						GCCTGGCGCTGGACTTCATGC	0.692000													2	9					0	0	0.115264	0	0
TP53	7157	broad.mit.edu	37	17	7577121	7577121	+	Missense_Mutation	SNP	G	A	A	rs121913343		TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542000	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			28	2					0	0	0.760397	0	0
Unknown	0	broad.mit.edu	37	17	21730916	21730916	+	Missense_Mutation	SNP	G	T	T	rs111245273	by1000genomes	TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr17:21730916G>T	uc002gyy.3	+	2	343	c.218G>T	c.(217-219)CGG>CTG	p.R73L						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;																		GTCCTGCGTCGGAGAGGTGGT	0.552000													7	86					0.00198382	0.0020468	0.248553	1	0
NOS2	4843	broad.mit.edu	37	17	26116671	26116671	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr17:26116671G>A	uc002gzu.2	-	3	418	c.154C>T	c.(154-156)CAG>TAG	p.Q52*	NOS2_uc010crh.1_Nonsense_Mutation_p.Q52*|NOS2_uc010wab.1_Nonsense_Mutation_p.Q52*	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	52					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	TCATTCTGCTGCTTGCTGAGG	0.502000													8	184					0	0	0.387290	0	0
TUBG1	7283	broad.mit.edu	37	17	40765009	40765009	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr17:40765009A>G	uc002ian.2	+	6	922	c.524A>G	c.(523-525)CAG>CGG	p.Q175R		NM_001070	NP_001061	P23258	TBG1_HUMAN	tubulin, gamma 1	175					G2/M transition of mitotic cell cycle|meiotic spindle organization|protein polymerization	condensed nuclear chromosome|cytosol|gamma-tubulin complex|polar microtubule	GTP binding|GTPase activity|protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.129)		TTTCCCAACCAGGACGAGATG	0.537000													5	181					0	0	0.217242	0	0
FAM38B	63895	broad.mit.edu	37	18	10691360	10691360	+	Silent	SNP	A	C	C			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr18:10691360A>C	uc002kor.3	-	6	884	c.744T>G	c.(742-744)GTT>GTG	p.V248V	FAM38B_uc002koq.2_Silent_p.V146V	NM_022068	NP_071351	Q9H5I5	PIEZ2_HUMAN	family with sequence similarity 38, member B	2291	Helical; (Potential).					integral to membrane	ion channel activity			ovary(1)	1						AAAGCTGGGCAACCAGGTTCT	0.428000													4	71					0	0	0.150653	0	0
TCEB3B	51224	broad.mit.edu	37	18	44561291	44561291	+	Silent	SNP	G	A	A			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr18:44561291G>A	uc002lcr.1	-	1	698	c.345C>T	c.(343-345)AAC>AAT	p.N115N	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	115					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						GGGCCGTCGCGTTTTCTGGGA	0.657000													22	45					0	0	0.717897	0	0
ZNF57	126295	broad.mit.edu	37	19	2917807	2917807	+	Missense_Mutation	SNP	A	C	C			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr19:2917807A>C	uc002lwr.2	+	4	1336	c.1188A>C	c.(1186-1188)CAA>CAC	p.Q396H	ZNF57_uc010xha.1_Missense_Mutation_p.Q364H	NM_173480	NP_775751	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	396	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		AATGTGAACAATGTGGGAAGG	0.428000													3	78					0	0	0.248553	0	0
NLRP5	126206	broad.mit.edu	37	19	56539141	56539141	+	Silent	SNP	C	T	T			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr19:56539141C>T	uc002qmj.2	+	7	1542	c.1542C>T	c.(1540-1542)GGC>GGT	p.G514G	NLRP5_uc002qmi.2_Silent_p.G495G	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	514	NACHT.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CCCCTCGAGGCGTGGTCCGGC	0.592000													14	16					0	0	0.500413	0	0
COLEC11	78989	broad.mit.edu	37	2	3691639	3691639	+	Silent	SNP	C	T	T			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr2:3691639C>T	uc002qya.2	+	7	895	c.747C>T	c.(745-747)GGC>GGT	p.G249G	COLEC11_uc002qxz.2_Silent_p.G246G|COLEC11_uc002qyb.2_Silent_p.G225G|COLEC11_uc002qyc.2_Silent_p.G225G|COLEC11_uc010ewo.2_Silent_p.G201G|COLEC11_uc010ewp.2_Silent_p.G223G|COLEC11_uc010ewq.2_Silent_p.G199G|COLEC11_uc010ewr.2_Silent_p.G199G|COLEC11_uc010ews.2_Silent_p.G175G	NM_024027	NP_076932	Q9BWP8	COL11_HUMAN	collectin sub-family member 11 isoform a	249	C-type lectin.					collagen	mannose binding				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.127)		TGGCCTCGGGCGGCTGGAACG	0.617000													47	59					0	0	0.870114	0	0
XDH	7498	broad.mit.edu	37	2	31589846	31589846	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr2:31589846C>T	uc002rnv.1	-	21	2291	c.2212G>A	c.(2212-2214)GGT>AGT	p.G738S		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	738					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TCTTGGCCACCGATGTATATC	0.537000													8	117					0	0	0.307466	0	0
LRP2	4036	broad.mit.edu	37	2	170026253	170026253	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr2:170026253C>A	uc002ues.2	-	60	11669	c.11456G>T	c.(11455-11457)GGA>GTA	p.G3819V		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3819	Extracellular (Potential).|LDL-receptor class A 33.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GTCAGCGGATCCATCGCATTT	0.428000													17	108					1.67942e-08	1.78954e-08	0.539581	1	0
HOXD3	3232	broad.mit.edu	37	2	177033896	177033896	+	Silent	SNP	G	A	A			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr2:177033896G>A	uc002ukt.1	+	2	230	c.54G>A	c.(52-54)CAG>CAA	p.Q18Q		NM_006898	NP_008829	P31249	HXD3_HUMAN	homeobox D3	18					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		GCACAATGCAGAAGGCTGCTT	0.527000													3	74					0	0	0.115264	0	0
IDH1	3417	broad.mit.edu	37	2	209113113	209113113	+	Missense_Mutation	SNP	G	A	A	rs121913499		TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr2:209113113G>A	uc002vcs.2	-	4	640	c.394C>T	c.(394-396)CGT>TGT	p.R132C	IDH1_uc002vct.2_Missense_Mutation_p.R132C|IDH1_uc002vcu.2_Missense_Mutation_p.R132C	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		TAAGCATGACGACCTATGATG	0.398000			Mis		gliobastoma 								40	46					0	0	0.870114	0	0
C20orf117	140710	broad.mit.edu	37	20	35445842	35445842	+	Silent	SNP	G	A	A			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr20:35445842G>A	uc002xgd.1	-	4	715	c.388C>T	c.(388-390)CTG>TTG	p.L130L	C20orf117_uc002xge.1_5'Flank	NM_199181	NP_954650	O94964	K0889_HUMAN	hypothetical protein LOC140710 isoform 2	130											0		Myeloproliferative disorder(115;0.00874)				GCCTTCCCCAGGGAGCGGGTT	0.453000													9	10					0	0	0.411799	0	0
KRTAP13-3	337960	broad.mit.edu	37	21	31798186	31798186	+	Silent	SNP	G	A	A			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr21:31798186G>A	uc002yob.1	-	1	45	c.45C>T	c.(43-45)CAC>CAT	p.H15H		NM_181622	NP_853653	Q3SY46	KR133_HUMAN	keratin associated protein 13-3	15						intermediate filament				ovary(1)|lung(1)	2						AGTAACCCCCGTGGGAGCAGG	0.542000													67	83					0	0	0.870114	0	0
CELSR1	9620	broad.mit.edu	37	22	46793715	46793715	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr22:46793715C>T	uc003bhw.1	-	12	5557	c.5557G>A	c.(5557-5559)GTC>ATC	p.V1853I	CELSR1_uc011arc.1_Missense_Mutation_p.V174I	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1853	Extracellular (Potential).|Laminin G-like 2.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		AGGGTGGCGACGTTGGTGGGC	0.602000													14	16					0	0	0.500413	0	0
CDCP1	64866	broad.mit.edu	37	3	45152168	45152168	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr3:45152168C>G	uc003com.2	-	4	956	c.821G>C	c.(820-822)TGT>TCT	p.C274S	CDCP1_uc003con.2_Missense_Mutation_p.C274S	NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	274	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		CTTCCTCTCACAGTTGGAGAG	0.592000													3	137					0	0	0.150653	0	0
FYCO1	79443	broad.mit.edu	37	3	46023170	46023170	+	Splice_Site	SNP	T	C	C			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr3:46023170T>C	uc003cpb.3	-	3	262	c.56_splice	c.e3-1	p.D19_splice	FYCO1_uc011bal.1_Splice_Site_p.D19_splice	NM_024513	NP_078789	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1						transport	integral to membrane	metal ion binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		TCACAGCATCTTTAAGACAAC	0.408000													26	33					0	0	0.796494	0	0
EPHA3	2042	broad.mit.edu	37	3	89480429	89480429	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr3:89480429A>G	uc003dqy.2	+	13	2491	c.2266A>G	c.(2266-2268)AGT>GGT	p.S756G	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	756	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CTTGATCAACAGTAACTTGGT	0.478000										TSP Lung(6;0.00050)			18	37					0	0	0.575678	0	0
SULT1E1	6783	broad.mit.edu	37	4	70709895	70709895	+	Silent	SNP	C	T	T			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr4:70709895C>T	uc003heo.2	-	7	869	c.756G>A	c.(754-756)TCG>TCA	p.S252S		NM_005420	NP_005411	P49888	ST1E1_HUMAN	estrogen sulfotransferase	252					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			ovary(1)	1						TCATGAAGGGCGACAATTTCT	0.393000													58	124					0	0	0.870114	0	0
GPR98	84059	broad.mit.edu	37	5	90106491	90106491	+	Silent	SNP	C	T	T			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr5:90106491C>T	uc003kju.2	+	74	15510	c.15414C>T	c.(15412-15414)CCC>CCT	p.P5138P	GPR98_uc003kjt.2_Silent_p.P2844P|GPR98_uc003kjw.2_Silent_p.P799P	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5138	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTTCCTTCCCCGAGACAACTG	0.448000													6	216					0	0	0.248553	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101631898	101631898	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr5:101631898C>G	uc003knm.2	-	1	356	c.69G>C	c.(67-69)TTG>TTC	p.L23F		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	23	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		GCGACGCAGACAAGCGGCGCA	0.577000													21	31					0	0	0.624587	0	0
TRIM41	90933	broad.mit.edu	37	5	180651435	180651435	+	Missense_Mutation	SNP	A	T	T			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr5:180651435A>T	uc003mne.1	+	1	1130	c.436A>T	c.(436-438)AGG>TGG	p.R146W	uc003mnb.1_3'UTR|TRIM41_uc003mnc.1_Missense_Mutation_p.R146W|TRIM41_uc003mnd.1_Missense_Mutation_p.R146W|TRIM41_uc003mnf.1_RNA	NM_033549	NP_291027	Q8WV44	TRI41_HUMAN	tripartite motif-containing 41 isoform 1	146	Glu-rich.					cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding				0	all_cancers(89;9.17e-06)|all_epithelial(37;1.19e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000209)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ggaggacctgaggggggagga	0.403000													28	47					0	0	0.706142	0	0
FILIP1	27145	broad.mit.edu	37	6	76024718	76024718	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr6:76024718T>C	uc003pia.2	-	5	1203	c.830A>G	c.(829-831)GAA>GGA	p.E277G	FILIP1_uc003phy.1_Missense_Mutation_p.E277G|FILIP1_uc003phz.2_Missense_Mutation_p.E178G|FILIP1_uc010kbe.2_Missense_Mutation_p.E280G|FILIP1_uc003pib.1_Missense_Mutation_p.E29G	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	277	Potential.									skin(3)|ovary(1)	4						CTCTTCTTCTTCCCTCAGCTT	0.423000													4	87					0	0	0.150653	0	0
LPA	4018	broad.mit.edu	37	6	161016555	161016555	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr6:161016555C>G	uc003qtl.2	-	22	3420	c.3300G>C	c.(3298-3300)AGG>AGC	p.R1100S		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3608	Kringle 32.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TGCAGTAGTTCCTGGTCAGGC	0.498000													6	66					0	0	0.335167	0	0
KIF25	3834	broad.mit.edu	37	6	168430272	168430272	+	Missense_Mutation	SNP	T	A	A			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr6:168430272T>A	uc003qwk.1	+	2	269	c.7T>A	c.(7-9)TGG>AGG	p.W3R	KIF25_uc010kkt.1_RNA|KIF25_uc003qwl.1_Missense_Mutation_p.W3R	NM_030615	NP_085118	Q9UIL4	KIF25_HUMAN	kinesin family member 25 isoform 1	3	Kinesin-motor.				microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity	p.W3C(1)		ovary(1)|pancreas(1)	2		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		CCAGATGACATGGACCTCAGG	0.602000													5	200					0	0	0.184627	0	0
MUC17	140453	broad.mit.edu	37	7	100684864	100684864	+	Silent	SNP	A	T	T			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr7:100684864A>T	uc003uxp.1	+	3	10220	c.10167A>T	c.(10165-10167)ATA>ATT	p.I3389I	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3389	Extracellular (Potential).|55.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GTACCAGCATACCAACCTCAA	0.502000													428	379					0	0	0.870114	0	0
C8orf47	203111	broad.mit.edu	37	8	99101917	99101917	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr8:99101917G>C	uc003yih.1	+	2	820	c.672G>C	c.(670-672)GAG>GAC	p.E224D		NM_173549	NP_775820	Q6P6B1	CH047_HUMAN	hypothetical protein LOC203111	224	Glu-rich.										0	Breast(36;2.31e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.214)			TTTCCAAAGAGAATGAATCTC	0.483000													17	33					0	0	0.557998	0	0
ZFAT	57623	broad.mit.edu	37	8	135649705	135649705	+	Silent	SNP	T	C	C			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr8:135649705T>C	uc003yup.2	-	3	622	c.447A>G	c.(445-447)GCA>GCG	p.A149A	ZFAT_uc003yun.2_Silent_p.A137A|ZFAT_uc003yuo.2_Silent_p.A137A|ZFAT_uc010meh.2_Silent_p.A137A|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Silent_p.A137A|ZFAT_uc010mej.2_Silent_p.A149A|ZFAT_uc003yur.2_Silent_p.A137A	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	149					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			AGCATTTACCTGCTTCTCCTT	0.468000													75	105					0	0	0.870114	0	0
OR5C1	392391	broad.mit.edu	37	9	125551909	125551909	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr9:125551909G>A	uc011lzd.1	+	1	698	c.698G>A	c.(697-699)CGC>CAC	p.R233H		NM_001001923	NP_001001923	Q8NGR4	OR5C1_HUMAN	olfactory receptor, family 5, subfamily C,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						ATCCACATGCGCTCGGTCGAG	0.592000													6	77					0	0	0.248553	0	0
PAGE1	8712	broad.mit.edu	37	X	49455852	49455852	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chrX:49455852C>T	uc004dom.2	-	4	425	c.292G>A	c.(292-294)GGG>AGG	p.G98R		NM_003785	NP_003776	O75459	GAGB1_HUMAN	P antigen family, member 1	98					cellular defense response					skin(1)	1	Ovarian(276;0.236)					GACTACCTACCTTCTGCGGGC	0.373000													13	52					0	0	0.479597	0	0
TSR2	90121	broad.mit.edu	37	X	54470611	54470611	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chrX:54470611G>C	uc004dte.2	+	4	437	c.435G>C	c.(433-435)GAG>GAC	p.E145D	TSR2_uc004dtf.2_Missense_Mutation_p.E50D	NM_058163	NP_477511	Q969E8	TSR2_HUMAN	TSR2, 20S rRNA accumulation, homolog	145					rRNA processing		protein binding				0						GTGTGGAAGAGATGGAGGTGA	0.498000													65	86					0	0	0.870114	0	0
ARHGEF9	23229	broad.mit.edu	37	X	62917174	62917174	+	Missense_Mutation	SNP	T	G	G			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chrX:62917174T>G	uc004dvl.2	-	4	1231	c.392A>C	c.(391-393)AAG>ACG	p.K131T	ARHGEF9_uc004dvj.1_Missense_Mutation_p.K20T|ARHGEF9_uc004dvk.1_5'UTR|ARHGEF9_uc011mos.1_Missense_Mutation_p.K110T|ARHGEF9_uc004dvm.1_Missense_Mutation_p.K110T|ARHGEF9_uc011mot.1_Missense_Mutation_p.K78T|ARHGEF9_uc004dvn.2_Missense_Mutation_p.K138T	NM_015185	NP_056000	O43307	ARHG9_HUMAN	Cdc42 guanine exchange factor 9	131	DH.				apoptosis|induction of apoptosis by extracellular signals|ion transmembrane transport|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(5)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	8						CCGGCACTGCTTCAGATAGCC	0.368000													4	76					0	0	0.150653	0	0
TAF1	6872	broad.mit.edu	37	X	70618475	70618475	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chrX:70618475G>A	uc004dzu.3	+	24	3722	c.3671G>A	c.(3670-3672)CGG>CAG	p.R1224Q	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Missense_Mutation_p.R1245Q|TAF1_uc004dzv.3_Missense_Mutation_p.R398Q	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	1224	HMG box.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				CGAAAAGAACGGCGGAGGATT	0.473000													24	34					0	0	0.706142	0	0
ATRX	546	broad.mit.edu	37	X	76813058	76813058	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chrX:76813058C>T	uc004ecp.3	-	30	6795	c.6563G>A	c.(6562-6564)CGA>CAA	p.R2188Q	ATRX_uc004ecq.3_Missense_Mutation_p.R2150Q|ATRX_uc004eco.3_Missense_Mutation_p.R1973Q	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	2188	Helicase C-terminal.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	ATCAACAACTCGAAAAGACAG	0.343000			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						53	59					0	0	0.870114	0	0
HDX	139324	broad.mit.edu	37	X	83723854	83723854	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chrX:83723854A>G	uc004eek.1	-	3	986	c.877T>C	c.(877-879)TGT>CGT	p.C293R	HDX_uc011mqv.1_Missense_Mutation_p.C293R|HDX_uc004eel.1_Missense_Mutation_p.C235R	NM_144657	NP_653258	Q7Z353	HDX_HUMAN	highly divergent homeobox	293						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)	2						ATGGACAAACAATTTCCTTCT	0.473000													9	121					0	0	0.335167	0	0
ALG13	79868	broad.mit.edu	37	X	110952273	110952273	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chrX:110952273G>C	uc011msy.1	+	5	865	c.831G>C	c.(829-831)GAG>GAC	p.E277D	ALG13_uc011msw.1_Missense_Mutation_p.E199D|ALG13_uc011msx.1_Missense_Mutation_p.E173D|ALG13_uc011msz.1_Missense_Mutation_p.E199D|ALG13_uc011mta.1_Missense_Mutation_p.E173D|ALG13_uc011mtb.1_Missense_Mutation_p.E173D			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	277	OTU.				dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						AAACTTTTGAGTCTGTAAGTA	0.388000													3	7					0	0	0.184627	0	0
MMGT1	93380	broad.mit.edu	37	X	135047268	135047268	+	Missense_Mutation	SNP	G	A	A	rs150859420		TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chrX:135047268G>A	uc004ezi.1	-	4	611	c.311C>T	c.(310-312)TCG>TTG	p.S104L	MMGT1_uc011mvw.1_Missense_Mutation_p.S169L	NM_173470	NP_775741	Q8N4V1	MMGT1_HUMAN	membrane magnesium transporter 1 precursor	104	Cytoplasmic (Potential).					early endosome membrane|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	magnesium ion transmembrane transporter activity				0						TGCTGTATCCGAAGGCCGGAA	0.358000													31	213					0	0	0.819951	0	0
AFF2	2334	broad.mit.edu	37	X	148035253	148035253	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chrX:148035253G>A	uc004fcp.2	+	10	2020	c.1541G>A	c.(1540-1542)CGT>CAT	p.R514H	AFF2_uc004fcq.2_Missense_Mutation_p.R504H|AFF2_uc004fcr.2_Missense_Mutation_p.R475H|AFF2_uc011mxb.1_Missense_Mutation_p.R479H|AFF2_uc004fcs.2_Missense_Mutation_p.R481H|AFF2_uc011mxc.1_Missense_Mutation_p.R155H	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	514					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					GAGGCACCTCGTGTGGCAACT	0.507000													75	100					0	0	0.870114	0	0
F8	2157	broad.mit.edu	37	X	154159216	154159216	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chrX:154159216T>C	uc004fmt.2	-	14	3020	c.2849A>G	c.(2848-2850)GAG>GGG	p.E950G		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	950	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TCCACCAGACTCAGTAAGGGG	0.373000													5	110					0	0	0.248553	0	0
F8	2157	broad.mit.edu	37	X	154250803	154250803	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chrX:154250803A>G	uc004fmt.2	-	1	196	c.25T>C	c.(25-27)TTC>CTC	p.F9L	F8_uc011mzx.1_Intron	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	9					acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CACAGAAAGAAGCAGGTGGAG	0.433000													3	129					0	0	0.115264	0	0
IL25	64806	broad.mit.edu	37	14	23845057	23845058	+	Frame_Shift_Del	DEL	TG	-	-			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr14:23845057_23845058delTG	uc001wjr.2	+	2	812_813	c.502_503delTG	c.(502-504)TGTfs	p.C168fs	IL25_uc001wjq.2_Frame_Shift_Del_p.C152fs|CMTM5_uc001wjs.2_5'Flank|CMTM5_uc001wjt.2_5'Flank|CMTM5_uc010akm.2_5'Flank|CMTM5_uc010akn.2_5'Flank|CMTM5_uc001wju.2_5'Flank|CMTM5_uc010ako.2_5'Flank	NM_022789	NP_073626	Q9H293	IL25_HUMAN	interleukin 25 isoform 1 precursor	168					inflammatory response	extracellular space|membrane	cytokine activity|interleukin-17E receptor binding			ovary(1)	1	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.00665)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0396)		TTCCTTAGCTTGTGTGTGTGTG	0.604													8	261	---	---	---	---					
SCAF1	58506	broad.mit.edu	37	19	50155567	50155569	+	In_Frame_Del	DEL	AAG	-	-			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr19:50155567_50155569delAAG	uc002poq.2	+	7	2045_2047	c.1921_1923delAAG	c.(1921-1923)AAGdel	p.K645del		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	645	Arg-rich.|Ser-rich.				mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		TGGCGGCAGCAAGAAGAAGAAGA	0.621													2	4	---	---	---	---					
CAPN11	11131	broad.mit.edu	37	6	44140054	44140055	+	Frame_Shift_Ins	INS	-	GGCTGCC	GGCTGCC	rs140464205	by1000genomes	TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr6:44140054_44140055insGGCTGCC	uc003owt.1	+	5	463_464	c.425_426insGGCTGCC	c.(424-426)CTGfs	p.L142fs		NM_007058	NP_008989	Q9UMQ6	CAN11_HUMAN	calpain 11	142	Calpain catalytic.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)|breast(1)	2	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TGCTGGCTGCTGGCTGCCATCG	0.584											OREG0017466	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	6	---	---	---	---					
PTCH1	5727	broad.mit.edu	37	9	98270593	98270595	+	In_Frame_Del	DEL	GCC	-	-			TCGA-HT-7693-01A-11D-2253-08	TCGA-HT-7693-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	6f18cb1e-8576-4fd3-a7a1-eb549089bad2	eb46a1d3-0492-467e-9576-fd233bbff676	g.chr9:98270593_98270595delGCC	uc004avk.3	-	1	237_239	c.49_51delGGC	c.(49-51)GGCdel	p.G17del	PTCH1_uc010mro.2_5'Flank|PTCH1_uc010mrp.2_5'Flank|PTCH1_uc010mrq.2_5'Flank|PTCH1_uc004avl.3_5'Flank|PTCH1_uc010mrr.2_Intron|PTCH1_uc004avm.3_Intron|PTCH1_uc010mrt.1_5'Flank|PTCH1_uc010mru.1_5'Flank|PTCH1_uc004avo.2_Intron|PTCH1_uc010mrv.1_Intron|PTCH1_uc010mrw.1_Intron	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	17	Cytoplasmic (Potential).|Gly-rich.				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				TACAGCCGCTGCCGCCGCCGCCG	0.700									Basal_Cell_Nevus_syndrome				2	4	---	---	---	---					
