Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
WASH7P	653635	broad.mit.edu	37	1	15834	15834	+	RNA	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr1:15834C>T	uc009vis.2	-	2		c.268G>A			WASH7P_uc009vit.2_RNA|WASH7P_uc001aae.3_RNA|WASH7P_uc009viu.2_RNA|WASH7P_uc001aab.3_RNA|WASH7P_uc001aah.3_RNA|WASH7P_uc009vir.2_RNA|WASH7P_uc009viq.2_RNA|WASH7P_uc001aac.3_RNA|WASH7P_uc009viv.2_RNA|WASH7P_uc009viw.2_RNA|WASH7P_uc009vix.2_RNA|WASH7P_uc009vjd.2_RNA					Homo sapiens cDNA FLJ31670 fis, clone NT2RI2004984.												0						CTCCAGCTTTCGCTCCTTCAT	0.647000													2	3					0	0	0.009096	0	0
MST1P2	11209	broad.mit.edu	37	1	16975947	16975947	+	RNA	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr1:16975947C>T	uc010och.1	+	11		c.1969C>T			MST1P2_uc001azl.3_RNA|MST1P2_uc009vox.2_RNA|MST1P2_uc001azm.3_RNA	NR_027504				Homo sapiens cDNA FLJ43241 fis, clone HEART1000010, weakly  similar to Hepatocyte growth factor-like protein precursor.												0						AGAGCCAGGCCTACAGCGGGT	0.577000													4	75					0	0	0.014758	0	0
HSPG2	3339	broad.mit.edu	37	1	22166420	22166420	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr1:22166420C>T	uc001bfj.2	-	72	9644	c.9604G>A	c.(9604-9606)GTG>ATG	p.V3202M	HSPG2_uc009vqd.2_Missense_Mutation_p.V3203M	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	3202	Ig-like C2-type 17.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CCCGTGTCCACGATCACCTCC	0.587000													112	181					0	0	0.014410	0	0
C1orf173	127254	broad.mit.edu	37	1	75037595	75037595	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr1:75037595C>T	uc001dgg.2	-	14	4018	c.3799G>A	c.(3799-3801)GTG>ATG	p.V1267M		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1267	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GTCCTTAGCACGACATCCACT	0.577000													6	198					0	0	0.001168	0	0
FAM46C	54855	broad.mit.edu	37	1	118166247	118166247	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr1:118166247C>T	uc001ehe.2	+	2	956	c.757C>T	c.(757-759)CGG>TGG	p.R253W		NM_017709	NP_060179	Q5VWP2	FA46C_HUMAN	hypothetical protein LOC54855	253											0	Lung SC(450;0.225)	all_cancers(81;0.000101)|all_lung(203;3.4e-06)|all_epithelial(167;4.98e-06)|Lung NSC(69;2.33e-05)		Lung(183;0.0576)|LUSC - Lung squamous cell carcinoma(189;0.192)|Colorectal(144;0.247)		CCTTCTTGTGCGGGACTTCAG	0.512000										Multiple Myeloma(3;1.13e-06)			4	94					0	0	0.014758	0	0
TMOD4	29765	broad.mit.edu	37	1	151146889	151146889	+	Silent	SNP	C	G	G			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr1:151146889C>G	uc001exc.3	-	3	448	c.258G>C	c.(256-258)GTG>GTC	p.V86V	TMOD4_uc001exb.2_5'Flank|TMOD4_uc001exd.2_RNA|TMOD4_uc010pct.1_Silent_p.V86V	NM_013353	NP_037485	Q9NZQ9	TMOD4_HUMAN	tropomodulin 4 (muscle)	86					muscle contraction	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTGTGAAGGGCACCAAGTCAT	0.562000													5	344					0	0	0.014758	0	0
FLG	2312	broad.mit.edu	37	1	152278795	152278795	+	Missense_Mutation	SNP	G	A	A			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr1:152278795G>A	uc001ezu.1	-	3	8603	c.8567C>T	c.(8566-8568)TCG>TTG	p.S2856L		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2856	Ser-rich.|Filaggrin 17.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGGTGACGCGACCCTGAGTG	0.577000									Ichthyosis				11	910					0	0	0.010729	0	0
ASPM	259266	broad.mit.edu	37	1	197086968	197086968	+	Missense_Mutation	SNP	T	G	G			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr1:197086968T>G	uc001gtu.2	-	17	4273	c.4016A>C	c.(4015-4017)AAA>ACA	p.K1339T	ASPM_uc001gtv.2_Missense_Mutation_p.K1339T|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1339					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						CTTTTCCTTTTTTAACATTAA	0.289000													6	298					0	0	0.001984	0	0
NLRP3	114548	broad.mit.edu	37	1	247582222	247582222	+	Silent	SNP	G	A	A			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr1:247582222G>A	uc001icr.2	+	3	264	c.126G>A	c.(124-126)CCG>CCA	p.P42P	NLRP3_uc001ics.2_Silent_p.P42P|NLRP3_uc001icu.2_Silent_p.P42P|NLRP3_uc001icw.2_Silent_p.P42P|NLRP3_uc001icv.2_Silent_p.P42P|NLRP3_uc010pyw.1_Silent_p.P40P|NLRP3_uc001ict.1_Silent_p.P40P	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	42	DAPIN.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TCCCCCTCCCGAGGGGTCAGA	0.562000													34	52					0	0	0.013726	0	0
AKR1E2	83592	broad.mit.edu	37	10	4881968	4881968	+	Silent	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr10:4881968C>T	uc001ihi.2	+	6	745	c.630C>T	c.(628-630)TGC>TGT	p.C210C	AKR1E2_uc001ihl.1_Intron|AKR1E2_uc010qam.1_Intron|AKR1E2_uc001ihh.1_Intron|AKR1E2_uc009xhw.2_Intron|AKR1E2_uc001ihj.2_RNA|AKR1E2_uc001ihk.2_Intron	NM_001040177	NP_001035267	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	210						cytoplasm	1,5-anhydro-D-fructose reductase activity				0						TCAGTTTTTGCCAATCCAGAG	0.433000													4	131					0	0	0.001168	0	0
ZNF438	220929	broad.mit.edu	37	10	31138346	31138346	+	Missense_Mutation	SNP	G	A	A			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr10:31138346G>A	uc010qdz.1	-	7	1423	c.988C>T	c.(988-990)CCC>TCC	p.P330S	ZNF438_uc001ivn.2_Missense_Mutation_p.P281S|ZNF438_uc010qdy.1_Missense_Mutation_p.P320S|ZNF438_uc001ivo.3_5'UTR|ZNF438_uc009xlg.2_Missense_Mutation_p.P330S|ZNF438_uc001ivp.3_Missense_Mutation_p.P320S|ZNF438_uc010qea.1_Missense_Mutation_p.P330S|ZNF438_uc010qeb.1_Missense_Mutation_p.P330S|ZNF438_uc010qec.1_5'UTR	NM_182755	NP_877432	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438 isoform a	330					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2		Prostate(175;0.0587)				GTGGTGGAGGGTATCTTATCA	0.463000													24	226					0	0	0.014323	0	0
CHST15	51363	broad.mit.edu	37	10	125801890	125801890	+	Silent	SNP	G	A	A	rs150036804		TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr10:125801890G>A	uc001lhl.2	-	3	1473	c.960C>T	c.(958-960)GCC>GCT	p.A320A	CHST15_uc001lhm.2_Silent_p.A320A|CHST15_uc001lhn.2_Silent_p.A320A|CHST15_uc010que.1_Silent_p.A320A|CHST15_uc001lho.2_Silent_p.A320A	NM_015892	NP_056976	Q7LFX5	CHSTF_HUMAN	B cell RAG associated protein	320	Lumenal (Potential).				hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			ovary(1)	1						TCTGGTGTGCGGCCAGGTCAA	0.527000													4	78					0	0	0.014758	0	0
TRIM68	55128	broad.mit.edu	37	11	4626616	4626616	+	Missense_Mutation	SNP	A	G	G			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr11:4626616A>G	uc001lzf.1	-	2	357	c.119T>C	c.(118-120)CTC>CCC	p.L40P	TRIM68_uc001lzg.1_5'UTR|TRIM68_uc010qyj.1_Intron|TRIM68_uc009yek.1_Missense_Mutation_p.L40P	NM_018073	NP_060543	Q6AZZ1	TRI68_HUMAN	ring finger protein 137	40	RING-type.				protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		GAGTCCAGAGAGACAGCTGTG	0.572000													46	21					0	0	0.014410	0	0
SPRYD5	84767	broad.mit.edu	37	11	55659044	55659044	+	Missense_Mutation	SNP	A	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr11:55659044A>T	uc010rip.1	+	7	1387	c.1295A>T	c.(1294-1296)TAC>TTC	p.Y432F	SPRYD5_uc010riq.1_Missense_Mutation_p.Y289F	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	432	B30.2/SPRY.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				TCCCTGATATACACCATCCCC	0.453000													6	119					0	0	0.001984	0	0
MS4A7	58475	broad.mit.edu	37	11	60150653	60150653	+	Silent	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr11:60150653C>T	uc001npe.2	+	2	184	c.39C>T	c.(37-39)AGC>AGT	p.S13S	MS4A7_uc001npf.2_Silent_p.S13S|MS4A7_uc001npg.2_Silent_p.S13S|MS4A7_uc001nph.2_Silent_p.S13S|MS4A14_uc001npi.2_Intron|MS4A7_uc009ymx.1_Silent_p.S13S	NM_206939	NP_996822	Q9GZW8	MS4A7_HUMAN	membrane-spanning 4-domains, subfamily A, member	13	Cytoplasmic (Potential).					integral to membrane	receptor activity			ovary(1)|central_nervous_system(1)	2						TTTCTCACAGCTTTACACCAA	0.463000													5	79					0	0	0.014758	0	0
NUMA1	4926	broad.mit.edu	37	11	71720101	71720101	+	Missense_Mutation	SNP	T	C	C			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr11:71720101T>C	uc001orl.1	-	19	5142	c.4970A>G	c.(4969-4971)CAT>CGT	p.H1657R	NUMA1_uc001orj.2_5'Flank|NUMA1_uc009ysw.1_Missense_Mutation_p.H1206R|NUMA1_uc001ork.1_Missense_Mutation_p.H521R|NUMA1_uc001orm.1_Missense_Mutation_p.H1643R|NUMA1_uc001orn.2_Missense_Mutation_p.H1220R	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1657	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						CTGTAGCTCATGGCCCAGCCG	0.592000			T	RARA	APL								26	43					0	0	0.015359	0	0
CACNA2D4	93589	broad.mit.edu	37	12	2017054	2017054	+	Silent	SNP	G	A	A			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr12:2017054G>A	uc001qjp.2	-	5	867	c.636C>T	c.(634-636)AAC>AAT	p.N212N	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Silent_p.N212N	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	212	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		TGTTGTACACGTTGGTGGGCA	0.627000													8	62					0	0	0.004482	0	0
RPAP3	79657	broad.mit.edu	37	12	48096531	48096531	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr12:48096531C>T	uc001rpr.2	-	2	209	c.93G>A	c.(91-93)TGG>TGA	p.W31*	RPAP3_uc010slk.1_Intron|RPAP3_uc001rps.2_Nonsense_Mutation_p.W31*	NM_024604	NP_078880	Q9H6T3	RPAP3_HUMAN	RNA polymerase II associated protein 3 isoform	31	TPR 1.						binding			ovary(1)	1	Lung SC(27;0.192)					TGTCTTTTTCCCAGTTTTCTA	0.323000													8	41					0	0	0.003080	0	0
MBD6	114785	broad.mit.edu	37	12	57919602	57919602	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr12:57919602C>T	uc001soj.1	+	6	1075	c.851C>T	c.(850-852)CCT>CTT	p.P284L	MBD6_uc001sok.1_Missense_Mutation_p.P151L|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	284	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						CACCCTGGTCCTGCCTCTCAG	0.672000													7	22					0	0	0.004482	0	0
SRGAP1	57522	broad.mit.edu	37	12	64437269	64437269	+	Missense_Mutation	SNP	G	A	A			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr12:64437269G>A	uc010ssp.1	+	6	771	c.715G>A	c.(715-717)GCA>ACA	p.A239T	SRGAP1_uc001srt.2_Missense_Mutation_p.A239T|SRGAP1_uc001srv.2_Missense_Mutation_p.A199T	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	239					axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		ATCAATTAAGGCACGGAACGA	0.348000													42	9					0	0	0.009718	0	0
PTPRR	5801	broad.mit.edu	37	12	71286551	71286551	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr12:71286551C>T	uc001swi.1	-	2	681	c.265G>A	c.(265-267)GCA>ACA	p.A89T		NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	89	Extracellular (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		GGGTCATATGCGGGTCTAGGA	0.453000													4	140					0	0	0.009096	0	0
NAP1L1	4673	broad.mit.edu	37	12	76453623	76453623	+	Silent	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr12:76453623C>T	uc001sxw.2	-	6	796	c.384G>A	c.(382-384)ACG>ACA	p.T128T	NAP1L1_uc001sxv.2_Silent_p.T86T|NAP1L1_uc001sxz.2_Intron|NAP1L1_uc001sxx.2_Silent_p.T128T|NAP1L1_uc001sxy.2_Silent_p.T65T|NAP1L1_uc010sty.1_Silent_p.T86T|NAP1L1_uc010stz.1_5'UTR|NAP1L1_uc010sua.1_Silent_p.T128T|NAP1L1_uc001syb.2_Silent_p.T128T|NAP1L1_uc001sya.2_Silent_p.T86T|NAP1L1_uc001syc.2_Silent_p.T128T	NM_139207	NP_631946	P55209	NP1L1_HUMAN	nucleosome assembly protein 1-like 1	128					DNA replication|nucleosome assembly|positive regulation of cell proliferation	chromatin assembly complex|melanosome	protein binding			ovary(1)|skin(1)	2		Colorectal(145;0.09)				ATTCTTCTTCCGTAGGTTCAT	0.308000													41	19					0	0	0.014410	0	0
FLT1	2321	broad.mit.edu	37	13	29008225	29008225	+	Missense_Mutation	SNP	A	G	G			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr13:29008225A>G	uc001usb.3	-	5	931	c.646T>C	c.(646-648)TAT>CAT	p.Y216H	FLT1_uc010aar.1_Missense_Mutation_p.Y216H|FLT1_uc001usc.3_Missense_Mutation_p.Y216H|FLT1_uc010tdp.1_Missense_Mutation_p.Y216H	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	216	Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TTTGTCTTATACAAATGCCCA	0.388000													3	139					0	0	0.004672	0	0
TTLL5	23093	broad.mit.edu	37	14	76241856	76241856	+	Silent	SNP	A	G	G			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr14:76241856A>G	uc001xrx.2	+	22	2371	c.2166A>G	c.(2164-2166)GCA>GCG	p.A722A	TTLL5_uc010ask.1_Silent_p.A736A|TTLL5_uc001xrz.2_Silent_p.A297A|TTLL5_uc001xry.1_RNA	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	722					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)		TCAAGCGAGCATCAAATAACC	0.463000													130	175					0	0	0.014410	0	0
BDKRB2	624	broad.mit.edu	37	14	96706767	96706767	+	Silent	SNP	A	G	G			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr14:96706767A>G	uc010avm.1	+	3	298	c.102A>G	c.(100-102)CAA>CAG	p.Q34Q	BDKRB2_uc010avl.1_3'UTR|BDKRB2_uc010twu.1_Silent_p.Q7Q|BDKRB2_uc001yfg.2_Silent_p.Q34Q	NM_000623	NP_000614	P30411	BKRB2_HUMAN	bradykinin receptor B2	34	Extracellular (Potential).				arachidonic acid secretion|elevation of cytosolic calcium ion concentration|transmembrane receptor protein tyrosine kinase signaling pathway	endosome|integral to plasma membrane	bradykinin receptor activity|phosphatidylinositol phospholipase C activity|protease binding|protein heterodimerization activity|type 1 angiotensin receptor binding			ovary(3)|breast(1)|kidney(1)	5		all_cancers(154;0.0678)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.226)		TCACCTTGCAAGGGCCCACTC	0.567000													6	459					0	0	0.003080	0	0
ADAM6	8755	broad.mit.edu	37	14	106993798	106993798	+	Splice_Site	SNP	C	T	T	rs7146961	by1000genomes	TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr14:106993798C>T	uc010tyt.1	-	187		c.8648_splice	c.e187+1							Parts of antibodies, mostly variable regions.												0						TCACACTGACCTCCCCTCACT	0.587000													6	307					0	0	0.001984	0	0
ELL3	80237	broad.mit.edu	37	15	44068328	44068328	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr15:44068328C>T	uc001zsw.1	-	3	593	c.190G>A	c.(190-192)GGT>AGT	p.G64S	ELL3_uc001zsv.1_Missense_Mutation_p.G18S|ELL3_uc001zsx.1_5'UTR|uc001zsy.2_5'Flank	NM_025165	NP_079441	Q9HB65	ELL3_HUMAN	elongation factor RNA polymerase II-like 3	64					positive regulation of transcription elongation, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				ovary(1)	1		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;7.81e-07)		CAGGACCAACCAGGGCCTGGG	0.632000													31	42					0	0	0.010818	0	0
FBN1	2200	broad.mit.edu	37	15	48729544	48729544	+	Silent	SNP	G	T	T	rs112989722		TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr15:48729544G>T	uc001zwx.1	-	52	6682	c.6354C>A	c.(6352-6354)ATC>ATA	p.I2118I	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	2118					heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CAGGTCCCACGATGATCCCAC	0.423000													32	9					4.3181e-19	4.56915e-19	0.013726	1	0
FAM86A	196483	broad.mit.edu	37	16	5135684	5135684	+	Silent	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr16:5135684C>T	uc002cyo.2	-	8	991	c.942G>A	c.(940-942)CTG>CTA	p.L314L	ALG1_uc002cyj.2_3'UTR|ALG1_uc002cym.2_3'UTR|ALG1_uc002cyn.2_3'UTR|ALG1_uc010bue.2_3'UTR|ALG1_uc010uxy.1_3'UTR|FAM86A_uc002cyp.2_Silent_p.L280L	NM_201400	NP_958802	Q96G04	FA86A_HUMAN	hypothetical protein LOC196483 isoform 1	314											0						CGTAGGGAAACAGTTTCTGCT	0.527000													5	139					0	0	0.003080	0	0
ZC3H7A	29066	broad.mit.edu	37	16	11857362	11857362	+	Silent	SNP	C	G	G			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr16:11857362C>G	uc002dbk.2	-	15	2172	c.1974G>C	c.(1972-1974)CTG>CTC	p.L658L	ZC3H7A_uc002dbj.2_RNA|ZC3H7A_uc002dbl.2_Silent_p.L658L|ZC3H7A_uc002dbm.1_Silent_p.L568L	NM_014153	NP_054872	Q8IWR0	Z3H7A_HUMAN	zinc finger CCCH-type containing 7A	658						nucleus	nucleic acid binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						TCCAGACTTTCAGTTCCACAA	0.403000													5	197					0	0	0.014758	0	0
PELP1	27043	broad.mit.edu	37	17	4578457	4578457	+	Silent	SNP	C	G	G			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr17:4578457C>G	uc002fyi.3	-	11	1417	c.1191G>C	c.(1189-1191)CTG>CTC	p.L397L	PELP1_uc010vsf.1_Silent_p.L250L	NM_014389	NP_055204	Q8IZL8	PELP1_HUMAN	proline, glutamic acid and leucine rich protein	397					transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			ovary(1)|central_nervous_system(1)	2						GGCGGCCGATCAGGATCCCAA	0.607000													7	22					0	0	0.013537	0	0
TP53	7157	broad.mit.edu	37	17	7577574	7577574	+	Missense_Mutation	SNP	T	C	C			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr17:7577574T>C	uc002gim.2	-	7	901	c.707A>G	c.(706-708)TAC>TGC	p.Y236C	TP53_uc002gig.1_Missense_Mutation_p.Y236C|TP53_uc002gih.2_Missense_Mutation_p.Y236C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y104C|TP53_uc010cng.1_Missense_Mutation_p.Y104C|TP53_uc002gii.1_Missense_Mutation_p.Y104C|TP53_uc010cnh.1_Missense_Mutation_p.Y236C|TP53_uc010cni.1_Missense_Mutation_p.Y236C|TP53_uc002gij.2_Missense_Mutation_p.Y236C|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Y143C|TP53_uc002gio.2_Missense_Mutation_p.Y104C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	236	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> S (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y236C(46)|p.Y236N(12)|p.Y236*(9)|p.Y236H(9)|p.0?(7)|p.Y236D(6)|p.Y236del(4)|p.Y236S(3)|p.Y236Y(2)|p.Y236fs*4(2)|p.Y236_M237delYM(1)|p.I232_Y236delIHYNY(1)|p.Y236fs*5(1)|p.H233fs*6(1)|p.Y236_M237insXX(1)|p.Y236_M243delYMCNSSCM(1)|p.V225fs*23(1)|p.Y236_M237>*L(1)|p.H233_C242del10(1)|p.N235_Y236delNY(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTTACACATGTAGTTGTAGTG	0.572000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			86	10					0	0	0.014410	0	0
MYH13	8735	broad.mit.edu	37	17	10213033	10213033	+	Missense_Mutation	SNP	T	C	C			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr17:10213033T>C	uc002gmk.1	-	34	4861	c.4771A>G	c.(4771-4773)AAA>GAA	p.K1591E		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1591	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						CTGTTTCTTTTTAGCTGCTCG	0.562000													3	16					0	0	0.004672	0	0
NCOR1	9611	broad.mit.edu	37	17	15974805	15974805	+	Missense_Mutation	SNP	T	C	C			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr17:15974805T>C	uc002gpo.2	-	30	4310	c.4070A>G	c.(4069-4071)CAA>CGA	p.Q1357R	NCOR1_uc002gpn.2_Missense_Mutation_p.Q1373R|NCOR1_uc002gpp.1_Missense_Mutation_p.Q1264R|NCOR1_uc010vwb.1_Intron|NCOR1_uc010coy.2_Missense_Mutation_p.Q265R|NCOR1_uc010vwc.1_Missense_Mutation_p.Q168R	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	1357	Interaction with ETO.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		TAAAATATCTTGCCTTGGAAT	0.453000													253	49					0	0	0.014410	0	0
KRTAP1-5	83895	broad.mit.edu	37	17	39183145	39183145	+	Missense_Mutation	SNP	A	G	G			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr17:39183145A>G	uc002hvu.2	-	1	310	c.263T>C	c.(262-264)ATC>ACC	p.I88T		NM_031957	NP_114163	Q9BYS1	KRA15_HUMAN	keratin associated protein 1.5	88	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament					0		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGGAGCTGATCTGGCAGCA	0.632000													3	35					0	0	0.014758	0	0
ACLY	47	broad.mit.edu	37	17	40030158	40030158	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr17:40030158G>A	uc002hyg.2	-	23	2711	c.2548C>T	c.(2548-2550)CAG>TAG	p.Q850*	ACLY_uc002hyh.2_Nonsense_Mutation_p.Q840*|ACLY_uc002hyi.2_Nonsense_Mutation_p.Q904*|ACLY_uc010wfx.1_Nonsense_Mutation_p.Q894*|ACLY_uc010wfy.1_Nonsense_Mutation_p.Q579*	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1	850					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				ATGAGCTCCTGTCCTCGCTCA	0.592000													22	89					0	0	0.016522	0	0
LPO	4025	broad.mit.edu	37	17	56344812	56344812	+	Missense_Mutation	SNP	G	A	A			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr17:56344812G>A	uc002ivt.2	+	12	2112	c.1796G>A	c.(1795-1797)GGT>GAT	p.G599D	LPO_uc010wns.1_Missense_Mutation_p.G540D|LPO_uc010dcp.2_Missense_Mutation_p.G516D|LPO_uc010dcq.2_Missense_Mutation_p.G270D|LPO_uc010dcr.2_Missense_Mutation_p.G162D	NM_006151	NP_006142	P22079	PERL_HUMAN	lactoperoxidase isoform 1 preproprotein	599					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|breast(1)	2						AAGTTACTGGGTCTCTACGGG	0.572000													65	65					0	0	0.014410	0	0
MPO	4353	broad.mit.edu	37	17	56355208	56355208	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr17:56355208C>T	uc002ivu.1	-	7	1361	c.1184G>A	c.(1183-1185)CGC>CAC	p.R395H		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	395					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	GCAGGGGATGCGCGCTGAGCG	0.617000													5	90					0	0	0.001168	0	0
ZNF750	79755	broad.mit.edu	37	17	80789719	80789719	+	Silent	SNP	G	C	C			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr17:80789719G>C	uc002kga.2	-	2	923	c.612C>G	c.(610-612)GGC>GGG	p.G204G	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	204						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TCCAGGGGTAGCCAGGAGTGT	0.577000													11	99					0	0	0.010729	0	0
MOCOS	55034	broad.mit.edu	37	18	33785151	33785151	+	Missense_Mutation	SNP	A	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr18:33785151A>T	uc002kzq.3	+	6	1153	c.1130A>T	c.(1129-1131)GAT>GTT	p.D377V		NM_017947	NP_060417	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	377					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	ATTTACAGCGATTCTGAGTTC	0.498000													6	182					0	0	0.001168	0	0
MATK	4145	broad.mit.edu	37	19	3784173	3784173	+	Missense_Mutation	SNP	G	A	A			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr19:3784173G>A	uc002lyt.2	-	5	711	c.311C>T	c.(310-312)GCG>GTG	p.A104V	MATK_uc002lyv.2_Missense_Mutation_p.A105V|MATK_uc002lyu.2_Missense_Mutation_p.A63V|MATK_uc010dtq.2_Missense_Mutation_p.A104V	NM_139355	NP_647612	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase isoform	104	SH3.				cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(2)|ovary(1)|lung(1)|large_intestine(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCCCGCAGCGCCCCAGCTGC	0.682000													21	21					0	0	0.010504	0	0
CIB3	117286	broad.mit.edu	37	19	16280488	16280488	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr19:16280488C>T	uc002nds.2	-	3	151	c.151G>A	c.(151-153)GAT>AAT	p.D51N	CIB3_uc010eae.2_5'UTR|CIB3_uc010eaf.2_Intron|CIB3_uc010eag.2_Intron	NM_054113	NP_473454	Q96Q77	CIB3_HUMAN	DNA-dependent protein kinase catalytic	51							calcium ion binding			ovary(1)	1						ACCTTCACATCGGGGCAGGTG	0.547000													5	83					0	0	0.014758	0	0
SBSN	374897	broad.mit.edu	37	19	36015811	36015811	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr19:36015811C>T	uc002oae.1	-	3	695	c.625G>A	c.(625-627)GGA>AGA	p.G209R	SBSN_uc002oad.1_Missense_Mutation_p.G552R	NM_198538	NP_940940	Q6UWP8	SBSN_HUMAN	suprabasin isoform 2 precursor	209	Ala/Gly/His-rich.					extracellular region				ovary(1)	1	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CTGGAAGATCCGCTTTGATGG	0.612000													8	24					0	0	0.004482	0	0
NBAS	51594	broad.mit.edu	37	2	15555741	15555741	+	Missense_Mutation	SNP	C	G	G			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr2:15555741C>G	uc002rcc.1	-	25	2892	c.2866G>C	c.(2866-2868)GAA>CAA	p.E956Q	NBAS_uc010exl.1_Intron|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	956										ovary(2)|liver(1)|skin(1)	4						ACTAAATATTCTTTTAATAGC	0.368000													87	108					0	0	0.014410	0	0
VIT	5212	broad.mit.edu	37	2	37035632	37035632	+	Silent	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr2:37035632C>T	uc002rpl.2	+	15	1628	c.1407C>T	c.(1405-1407)AAC>AAT	p.N469N	VIT_uc002rpm.2_Silent_p.N447N|VIT_uc010ezv.2_Silent_p.N425N|VIT_uc010ezw.2_Silent_p.N426N	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	454	VWFA 1.					proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				GCAGAACAAACGGCTTCTACT	0.622000													24	51					0	0	0.008361	0	0
KIAA1841	84542	broad.mit.edu	37	2	61315601	61315601	+	Silent	SNP	A	C	C			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr2:61315601A>C	uc002saw.3	+	10	1389	c.1086A>C	c.(1084-1086)ATA>ATC	p.I362I	KIAA1841_uc002sax.3_Silent_p.I216I|KIAA1841_uc002say.2_Silent_p.I362I|KIAA1841_uc002sav.3_Silent_p.I362I	NM_001129993	NP_001123465	Q6NSI8	K1841_HUMAN	KIAA1841 protein isoform a	362											0			Epithelial(17;0.193)			ATATTCACATAAGGTGTCGTG	0.219000													35	26					0	0	0.017118	0	0
Unknown	0	broad.mit.edu	37	2	90077808	90077808	+	RNA	SNP	T	A	A			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr2:90077808T>A	uc010fhm.2	+	13		c.1385T>A								Parts of antibodies, mostly variable regions.																		CTCTTCCTCCTGCTACTCTGG	0.537000													4	184					0	0	0.009096	0	0
FAM123C	205147	broad.mit.edu	37	2	131520982	131520982	+	Missense_Mutation	SNP	A	G	G			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr2:131520982A>G	uc002trw.2	+	2	1527	c.1337A>G	c.(1336-1338)GAG>GGG	p.E446G	FAM123C_uc010fmv.2_Missense_Mutation_p.E446G|FAM123C_uc010fms.1_Missense_Mutation_p.E446G|FAM123C_uc010fmt.1_Missense_Mutation_p.E446G|FAM123C_uc010fmu.1_Missense_Mutation_p.E446G	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	446										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		TGCGTGTCTGAGAGTCTGTCA	0.662000													3	89					0	0	0.004672	0	0
ADAM23	8745	broad.mit.edu	37	2	207310230	207310230	+	Missense_Mutation	SNP	C	G	G			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr2:207310230C>G	uc002vbq.2	+	2	637	c.414C>G	c.(412-414)CAC>CAG	p.H138Q	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	138					cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		AGGCAAGACACCAGCAAAAAC	0.398000													44	100					0	0	0.009718	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								21	60					0	0	0.014323	0	0
SP100	6672	broad.mit.edu	37	2	231314895	231314895	+	Missense_Mutation	SNP	G	A	A			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr2:231314895G>A	uc002vqt.2	+	8	886	c.745G>A	c.(745-747)GAA>AAA	p.E249K	SP100_uc002vqs.2_Missense_Mutation_p.E249K|SP100_uc002vqu.1_Missense_Mutation_p.E249K|SP100_uc010zmb.1_Missense_Mutation_p.E249K|SP100_uc002vqq.1_Missense_Mutation_p.E249K|SP100_uc002vqr.1_Missense_Mutation_p.E224K|SP100_uc010zmc.1_Missense_Mutation_p.E224K|SP100_uc002vqv.1_Missense_Mutation_p.E213K	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2	249					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGAGTCCTGCGAACAAATTGC	0.473000													75	59					0	0	0.014410	0	0
ZNF343	79175	broad.mit.edu	37	20	2464637	2464637	+	Missense_Mutation	SNP	G	C	C			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr20:2464637G>C	uc002wge.1	-	6	1458	c.970C>G	c.(970-972)CCT>GCT	p.P324A	ZNF343_uc010gao.1_Missense_Mutation_p.P324A|ZNF343_uc002wgd.1_Missense_Mutation_p.P234A	NM_024325	NP_077301	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	324					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						CACAAATAAGGCTTCTCTTCT	0.493000													16	51					0	0	0.003163	0	0
SNRPB2	6629	broad.mit.edu	37	20	16712312	16712312	+	Splice_Site	SNP	G	C	C			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr20:16712312G>C	uc002wph.1	+	2	182	c.-34_splice	c.e2-1		SNRPB2_uc002wpi.1_Splice_Site	NM_003092	NP_003083	P08579	RU2B_HUMAN	small nuclear ribonucleoprotein polypeptide B''							catalytic step 2 spliceosome|nucleoplasm|U2 snRNP	nucleotide binding|protein binding|RNA binding			large_intestine(1)	1						TTTTATAACAGATTTTTTACT	0.239000													19	104					0	0	0.012319	0	0
LIPI	149998	broad.mit.edu	37	21	15561431	15561431	+	Missense_Mutation	SNP	G	C	C			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr21:15561431G>C	uc002yjm.2	-	2	429	c.419C>G	c.(418-420)ACT>AGT	p.T140S	LIPI_uc010gkw.1_Missense_Mutation_p.T73S	NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	119					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		ATAAATAAAAGTTGTAGCACC	0.363000													52	66					0	0	0.014410	0	0
DIP2A	23181	broad.mit.edu	37	21	47978201	47978201	+	Silent	SNP	T	C	C			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr21:47978201T>C	uc002zjo.2	+	32	4047	c.3864T>C	c.(3862-3864)ATT>ATC	p.I1288I	DIP2A_uc011afz.1_Silent_p.I1284I|DIP2A_uc002zjr.2_Silent_p.I255I|DIP2A_uc002zjs.2_5'Flank	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	1288					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		GGCCCAGGATTGCGCTGACCC	0.667000													6	22					0	0	0.001984	0	0
GGT1	2678	broad.mit.edu	37	22	25011062	25011062	+	Missense_Mutation	SNP	C	G	G	rs138472970	by1000genomes	TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr22:25011062C>G	uc003aan.1	+	7	837	c.350C>G	c.(349-351)ACC>AGC	p.T117S	GGT1_uc003aas.1_Missense_Mutation_p.T117S|GGT1_uc003aat.1_Missense_Mutation_p.T117S|GGT1_uc003aau.1_Missense_Mutation_p.T117S|GGT1_uc003aav.1_Missense_Mutation_p.T117S|GGT1_uc003aaw.1_Missense_Mutation_p.T117S|GGT1_uc003aax.1_Missense_Mutation_p.T117S	NM_013430	NP_038347	P19440	GGT1_HUMAN	gamma-glutamyltransferase 1 precursor	117	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding				0					Glutathione(DB00143)	GCCTTTGCCACCATGTTCAAC	0.637000													2	40					0	0	0.004672	0	0
GPR149	344758	broad.mit.edu	37	3	154145322	154145322	+	Missense_Mutation	SNP	G	A	A			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr3:154145322G>A	uc003faa.2	-	2	1257	c.1157C>T	c.(1156-1158)GCG>GTG	p.A386V		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	386	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			CCCATCGGACGCCACTGCATA	0.488000													37	6					0	0	0.006230	0	0
SPEF2	79925	broad.mit.edu	37	5	35709170	35709170	+	Missense_Mutation	SNP	A	G	G			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr5:35709170A>G	uc003jjo.2	+	19	2897	c.2786A>G	c.(2785-2787)CAT>CGT	p.H929R	SPEF2_uc003jjq.3_Missense_Mutation_p.H924R|SPEF2_uc003jjp.1_Missense_Mutation_p.H415R	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	929					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAGGAAATTCATCAAAGCCAT	0.418000													21	145					0	0	0.016522	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41045922	41045922	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr5:41045922C>T	uc003jmj.3	-	18	2252	c.1762G>A	c.(1762-1764)GTG>ATG	p.V588M	HEATR7B2_uc003jmi.3_Missense_Mutation_p.V143M	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	588	HEAT 7.						binding			ovary(6)|central_nervous_system(2)	8						GTCCAGGCCACATCACTGATC	0.433000													35	235					0	0	0.006230	0	0
PAIP1	10605	broad.mit.edu	37	5	43529961	43529961	+	Missense_Mutation	SNP	C	G	G			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr5:43529961C>G	uc003job.2	-	10	1520	c.1273G>C	c.(1273-1275)GAA>CAA	p.E425Q	PAIP1_uc003joa.2_Missense_Mutation_p.E346Q|PAIP1_uc010ivp.2_Intron|PAIP1_uc010ivo.2_RNA|PAIP1_uc003joc.2_Missense_Mutation_p.E313Q	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	425					mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					TCAAGTAATTCTTGGTATTTC	0.333000													3	120					0	0	0.004672	0	0
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139917069	139917069	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr5:139917069C>T	uc003lfs.1	+	31	7247	c.7123C>T	c.(7123-7125)CGA>TGA	p.R2375*	ANKHD1_uc003lfr.2_Nonsense_Mutation_p.R2375*|ANKHD1-EIF4EBP3_uc011czh.1_Nonsense_Mutation_p.R1131*|ANKHD1_uc003lfw.2_Nonsense_Mutation_p.R1030*|ANKHD1_uc010jfl.2_Nonsense_Mutation_p.R751*|ANKHD1-EIF4EBP3_uc003lfx.1_Nonsense_Mutation_p.R529*	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	2375						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGACTGGCCCGAATTCGGCA	0.552000													54	7					0	0	0.014410	0	0
SH3TC2	79628	broad.mit.edu	37	5	148407828	148407828	+	Silent	SNP	G	A	A			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr5:148407828G>A	uc003lpu.2	-	11	1619	c.1467C>T	c.(1465-1467)TTC>TTT	p.F489F	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc010jgw.2_Silent_p.F133F|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_Silent_p.F36F|SH3TC2_uc010jgx.2_Silent_p.F482F|SH3TC2_uc003lpv.1_Silent_p.F36F|SH3TC2_uc011dbz.1_Silent_p.F374F	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	489							binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGAGAAGGAGAAGTCATAGA	0.483000													4	133					0	0	0.009096	0	0
ATP10B	23120	broad.mit.edu	37	5	160047926	160047926	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr5:160047926C>T	uc003lym.1	-	15	2691	c.1844G>A	c.(1843-1845)GGG>GAG	p.G615E	ATP10B_uc010jit.1_5'UTR|ATP10B_uc003lyn.2_Missense_Mutation_p.G173E	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	615	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGGGACGTCCCCAGAGCCTT	0.488000													6	216					0	0	0.003080	0	0
CAPN11	11131	broad.mit.edu	37	6	44143869	44143869	+	Missense_Mutation	SNP	C	G	G			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr6:44143869C>G	uc003owt.1	+	8	934	c.896C>G	c.(895-897)TCT>TGT	p.S299C	CAPN11_uc011dvn.1_5'Flank	NM_007058	NP_008989	Q9UMQ6	CAN11_HUMAN	calpain 11	299	Calpain catalytic.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)|breast(1)	2	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CACGCTTACTCTGTGACTGGC	0.488000													17	31					0	0	0.012319	0	0
HTR1B	3351	broad.mit.edu	37	6	78172156	78172156	+	Missense_Mutation	SNP	G	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr6:78172156G>T	uc003pil.1	-	1	965	c.965C>A	c.(964-966)GCC>GAC	p.A322D		NM_000863	NP_000854	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B	322	Helical; Name=6; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity				0		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)	CACAATAAAGGCTCCCAAAAT	0.507000													103	119					1.22879e-52	1.31553e-52	0.014410	1	0
TPBG	7162	broad.mit.edu	37	6	83075656	83075656	+	Silent	SNP	G	A	A			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr6:83075656G>A	uc003pjn.3	+	3	1914	c.978G>A	c.(976-978)CCG>CCA	p.P326P	TPBG_uc010kbj.2_Silent_p.P326P|TPBG_uc003pjo.2_Silent_p.P326P	NM_006670	NP_006661	Q13641	TPBG_HUMAN	trophoblast glycoprotein precursor	326	Extracellular (Potential).|LRRCT.				cell adhesion	integral to plasma membrane				central_nervous_system(1)	1		all_cancers(76;0.000805)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0897)		BRCA - Breast invasive adenocarcinoma(397;0.107)		GTGCATATCCGGAAAAAATGA	0.542000													47	105					0	0	0.013114	0	0
TRPV5	56302	broad.mit.edu	37	7	142626123	142626123	+	Missense_Mutation	SNP	A	G	G			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr7:142626123A>G	uc003wby.1	-	5	844	c.580T>C	c.(580-582)TCC>CCC	p.S194P	TRPV5_uc003wbz.2_Missense_Mutation_p.S194P	NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	194	Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					TTACCCAGGGAGTCCTGGGCC	0.612000													9	42					0	0	0.004482	0	0
CDH17	1015	broad.mit.edu	37	8	95142932	95142932	+	Missense_Mutation	SNP	G	A	A			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr8:95142932G>A	uc003ygh.2	-	17	2445	c.2320C>T	c.(2320-2322)CGG>TGG	p.R774W	CDH17_uc011lgo.1_Intron|CDH17_uc011lgp.1_Missense_Mutation_p.R774W	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	774	Cadherin 7.|Extracellular (Potential).					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			CCTGCTGGCCGGAAACAACTT	0.448000													30	119					0	0	0.010818	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070687	141070687	+	Silent	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr9:141070687C>T	uc004com.2	+	4	351	c.90C>T	c.(88-90)GCC>GCT	p.A30A	TUBBP5_uc010ncq.2_Nonsense_Mutation_p.Q208*					RecName: Full=Putative tubulin beta-4q chain;												0						ACAACTGGGCCAAGGGACGCT	0.577000													4	5					0	0	0.014758	0	0
TSIX	9383	broad.mit.edu	37	X	73047524	73047524	+	RNA	SNP	A	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chrX:73047524A>T	uc004ebn.2	+	1		c.35485A>T			XIST_uc004ebm.1_RNA	NR_003255				Homo sapiens XIST antisense RNA (non-protein coding) (TSIX), non-coding RNA.												0						GAGAAAGGAGAGGTAGACAGA	0.408000													9	5					0	0	0.004482	0	0
COL4A6	1288	broad.mit.edu	37	X	107454952	107454952	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chrX:107454952C>T	uc004enw.3	-	7	566	c.463G>A	c.(463-465)GGA>AGA	p.G155R	COL4A6_uc004env.3_Missense_Mutation_p.G154R|COL4A6_uc011msn.1_Missense_Mutation_p.G154R|COL4A6_uc010npk.2_Missense_Mutation_p.G154R	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	155	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						CCTTTTGATCCTTTCTGACCA	0.403000									Alport_syndrome_with_Diffuse_Leiomyomatosis				4	97					0	0	0.014758	0	0
CHD5	26038	broad.mit.edu	37	1	6202211	6202212	+	Frame_Shift_Ins	INS	-	A	A			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr1:6202211_6202212insA	uc001amb.1	-	15	2512_2513	c.2412_2413insT	c.(2410-2415)AGTGGGfs	p.S804fs	CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	804_805	Helicase ATP-binding.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		ACCTTCTTCCCACTCCGAATGG	0.599													115	202	---	---	---	---					
ESPNP	284729	broad.mit.edu	37	1	17034125	17034126	+	Frame_Shift_Ins	INS	-	AGCT	AGCT	rs141324796	by1000genomes	TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr1:17034125_17034126insAGCT	uc001azn.1	-	3	478_479	c.364_365insAGCT	c.(364-366)TGGfs	p.W122fs	ESPNP_uc010ocj.1_Frame_Shift_Ins_p.W52fs	NR_026567				RecName: Full=Espin; AltName: Full=Ectoplasmic specialization protein; AltName: Full=Autosomal recessive deafness type 36 protein;												0						CAGCAGCAGCCAGCTGAGCACC	0.663													4	4	---	---	---	---					
RNF139	11236	broad.mit.edu	37	8	125498877	125498880	+	Frame_Shift_Del	DEL	TTTA	-	-			TCGA-DB-5277-01A-01D-1468-08	TCGA-DB-5277-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff5b06bf-99d6-4276-8646-b91ef5ed480e	54fcd6db-49a2-47d2-9086-3f7b89e39015	g.chr8:125498877_125498880delTTTA	uc003yrc.2	+	2	1330_1333	c.987_990delTTTA	c.(985-990)GTTTTAfs	p.V329fs		NM_007218	NP_009149	Q8WU17	RN139_HUMAN	ring finger protein 139	329_330	Helical; (Potential).				negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			TTGCACCTGTTTTATTTTTTATTT	0.412									Renal_Cell_Cancer_associated_with_constitutional_translocation_of_chromosome_3				53	506	---	---	---	---					
