Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CHD5	26038	broad.mit.edu	37	1	6186737	6186737	+	Missense_Mutation	SNP	G	A	A			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr1:6186737G>A	uc001amb.1	-	26	4073	c.3973C>T	c.(3973-3975)CGG>TGG	p.R1325W	CHD5_uc001alz.1_Missense_Mutation_p.R182W|CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1325					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TAGTGGTGCCGCAGCAGCTTC	0.627													15	57					0	0	0.520397	0	0
MST1P2	11209	broad.mit.edu	37	1	16974745	16974745	+	RNA	SNP	G	A	A	rs28526603	by1000genomes	TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr1:16974745G>A	uc010och.1	+	7		c.1205G>A			MST1P2_uc001azk.2_RNA|MST1P2_uc001azl.3_RNA|MST1P2_uc009vox.2_RNA|MST1P2_uc001azm.3_RNA	NR_027504				Homo sapiens cDNA FLJ43241 fis, clone HEART1000010, weakly  similar to Hepatocyte growth factor-like protein precursor.												0						CCTGGAACCGGAGGGCCGGGG	0.711													3	35					0	0	0.248553	0	0
TESK2	10420	broad.mit.edu	37	1	45887455	45887455	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr1:45887455C>T	uc001cns.1	-	3	689	c.286G>A	c.(286-288)GCA>ACA	p.A96T	TESK2_uc009vxr.1_Missense_Mutation_p.A96T|TESK2_uc010olo.1_Missense_Mutation_p.A13T|TESK2_uc009vxs.1_5'UTR|TESK2_uc010olp.1_Missense_Mutation_p.A96T	NM_007170	NP_009101	Q96S53	TESK2_HUMAN	testis-specific protein kinase 2	96	Protein kinase.				actin cytoskeleton organization|focal adhesion assembly|spermatogenesis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(2)|breast(2)|pancreas(1)	5	Acute lymphoblastic leukemia(166;0.155)					AGCATGTTTGCCCGGTTACTG	0.423													71	95					0	0	0.870114	0	0
MBL1P	8512	broad.mit.edu	37	10	81666473	81666473	+	RNA	SNP	A	G	G			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr10:81666473A>G	uc001kbf.2	+	2		c.298A>G								Homo sapiens mannose-binding protein-A pseudogene (MBL1P1) mRNA sequence.												0						GAAGATGCCCAGAAGAGAAAT	0.438													3	67					0	0	0.115264	0	0
CD44	960	broad.mit.edu	37	11	35231542	35231542	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr11:35231542C>T	uc001mvu.2	+	13	1981	c.1547C>T	c.(1546-1548)TCA>TTA	p.S516L	CD44_uc001mvv.2_Missense_Mutation_p.S473L|CD44_uc001mvw.2_Missense_Mutation_p.S267L|CD44_uc001mvx.2_Intron|CD44_uc001mvy.2_Intron|CD44_uc001mwc.3_Intron|CD44_uc010rer.1_Intron|CD44_uc009ykh.2_Intron|CD44_uc010res.1_Missense_Mutation_p.S80L|CD44_uc010ret.1_RNA|CD44_uc010reu.1_Missense_Mutation_p.S44L	NM_000610	NP_000601	P16070	CD44_HUMAN	CD44 antigen isoform 1 precursor	516	Extracellular (Potential).|Stem.				cell-cell adhesion|cell-matrix adhesion|interferon-gamma-mediated signaling pathway|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation	cell surface|Golgi apparatus|integral to plasma membrane	collagen binding|hyaluronic acid binding|receptor activity			pancreas(1)	1	all_cancers(35;0.212)|all_lung(20;0.0874)|all_epithelial(35;0.112)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.00731)		Hyaluronidase(DB00070)	TTCTCTACATCACATGAAGGC	0.388													34	135					0	0	0.769981	0	0
TMEM132A	54972	broad.mit.edu	37	11	60703701	60703701	+	Silent	SNP	A	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr11:60703701A>T	uc001nqj.2	+	11	2587	c.2394A>T	c.(2392-2394)GCA>GCT	p.A798A	TMEM132A_uc001nqi.2_Silent_p.A799A|TMEM132A_uc001nqm.2_Silent_p.A8A	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	798	Binds to HSPA5/GRP78 (By similarity).|Confers cellular localization similar to full-length form (By similarity).|Extracellular (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						GGCAGGTGGCAGGCAGTGTCG	0.607													11	60					0	0	0.479597	0	0
MTL5	9633	broad.mit.edu	37	11	68480850	68480850	+	Missense_Mutation	SNP	G	A	A			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr11:68480850G>A	uc001ooc.2	-	8	1186	c.1046C>T	c.(1045-1047)GCT>GTT	p.A349V		NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	349					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			TGGCTGGAAAGCTTCTGGATT	0.468													55	261					0	0	0.870114	0	0
LRRC32	2615	broad.mit.edu	37	11	76371899	76371899	+	Silent	SNP	G	C	C			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr11:76371899G>C	uc001oxq.3	-	3	981	c.738C>G	c.(736-738)ACC>ACG	p.T246T	LRRC32_uc001oxr.3_Silent_p.T246T|LRRC32_uc010rsf.1_Silent_p.T246T	NM_005512	NP_005503	Q14392	LRC32_HUMAN	leucine rich repeat containing 32 precursor	246	LRR 9.|Extracellular (Potential).					integral to plasma membrane					0						GGTCAAGCCAGGTGAGCTGGA	0.617													19	90					0	0	0.575678	0	0
MAML2	84441	broad.mit.edu	37	11	95826019	95826019	+	Silent	SNP	G	A	A			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr11:95826019G>A	uc001pfw.1	-	2	2461	c.1176C>T	c.(1174-1176)TCC>TCT	p.S392S		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	mastermind-like 2	392					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				AGTTGGCCATGGAGAATGCGG	0.597			T	MECT1|CRTC3	salivary gland mucoepidermoid								22	11					0	0	0.592651	0	0
DPPA3	359787	broad.mit.edu	37	12	7864237	7864237	+	Missense_Mutation	SNP	G	A	A			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr12:7864237G>A	uc001qtf.2	+	1	149	c.71G>A	c.(70-72)CGG>CAG	p.R24Q		NM_199286	NP_954980	Q6W0C5	DPPA3_HUMAN	stella	24						cytoplasm|nucleus					0				Kidney(36;0.0887)		GAAAATTCCCGGGACGATTCA	0.458													3	62					0	0	0.150653	0	0
AICDA	57379	broad.mit.edu	37	12	8757943	8757943	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr12:8757943G>A	uc001qur.2	-	3	374	c.295C>T	c.(295-297)CGA>TGA	p.R99*	AICDA_uc001qup.1_Nonsense_Mutation_p.R94*|AICDA_uc001quq.1_Nonsense_Mutation_p.R94*|AICDA_uc009zgd.1_Intron	NM_020661	NP_065712	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	99					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung SC(5;0.184)					GGGTTCCCTCGCAGAAAGTCG	0.667									Immune_Deficiency_with_Hyper-IgM				15	56					0	0	0.500413	0	0
RARG	5916	broad.mit.edu	37	12	53609147	53609147	+	Silent	SNP	G	A	A			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr12:53609147G>A	uc001sce.2	-	5	890	c.405C>T	c.(403-405)AAC>AAT	p.N135N	RARG_uc001scd.2_Silent_p.N124N|RARG_uc010sob.1_Silent_p.N113N|RARG_uc001scf.2_Silent_p.N135N|RARG_uc001scg.2_Silent_p.N63N|RARG_uc010soc.1_Silent_p.N14N|RARG_uc010sod.1_Silent_p.N172N	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	135	NR C4-type.|Nuclear receptor.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	TGGTCACCTTGTTGATGATAC	0.547													27	113					0	0	0.740014	0	0
C12orf66	144577	broad.mit.edu	37	12	64588283	64588283	+	Missense_Mutation	SNP	C	A	A			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr12:64588283C>A	uc001srw.3	-	3	736	c.677G>T	c.(676-678)TGG>TTG	p.W226L	C12orf66_uc009zql.2_Missense_Mutation_p.W173L	NM_152440	NP_689653	Q96MD2	CL066_HUMAN	hypothetical protein LOC144577	226										ovary(1)	1						GATCTGGCCCCACGTCTGCAG	0.537													3	68					0.00909568	0.0093519	0.150653	1	0
ACSS3	79611	broad.mit.edu	37	12	81647382	81647382	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr12:81647382C>T	uc001szl.1	+	15	2019	c.1928C>T	c.(1927-1929)CCC>CTC	p.P643L	ACSS3_uc001szm.1_Missense_Mutation_p.P642L|ACSS3_uc001szn.1_Missense_Mutation_p.P325L	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	643						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						AAACAGCTACCCAAAACCAGA	0.428													21	108					0	0	0.575678	0	0
C12orf51	283450	broad.mit.edu	37	12	112674788	112674788	+	Missense_Mutation	SNP	G	A	A			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr12:112674788G>A	uc009zwc.2	-	28	4157	c.4139C>T	c.(4138-4140)GCG>GTG	p.A1380V		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						ATCCTGGAGCGCGTCATTCCC	0.572													6	26					0	0	0.248553	0	0
RNF17	56163	broad.mit.edu	37	13	25425618	25425618	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr13:25425618C>T	uc001upr.2	+	24	3270	c.3229C>T	c.(3229-3231)CCT>TCT	p.P1077S	RNF17_uc010tdd.1_Missense_Mutation_p.P936S|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.P1073S|RNF17_uc001ups.2_Missense_Mutation_p.P1016S|RNF17_uc010aac.2_Missense_Mutation_p.P275S|RNF17_uc010aad.2_Missense_Mutation_p.P129S	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1077					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		ATGGCCATTACCTGTGAAAAT	0.343													11	60					0	0	0.361761	0	0
CCNA1	8900	broad.mit.edu	37	13	37015366	37015366	+	Missense_Mutation	SNP	T	C	C			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr13:37015366T>C	uc001uvr.3	+	7	1560	c.1210T>C	c.(1210-1212)TGG>CGG	p.W404R	CCNA1_uc010teo.1_Missense_Mutation_p.W360R|CCNA1_uc010abq.2_Missense_Mutation_p.W360R|CCNA1_uc010abp.2_Missense_Mutation_p.W360R|CCNA1_uc001uvs.3_Missense_Mutation_p.W403R|CCNA1_uc010abr.2_RNA	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	404					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		CAAGCACTTTTGGGTAAGATT	0.398													39	73					0	0	0.847076	0	0
SMAD9	4093	broad.mit.edu	37	13	37427768	37427768	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr13:37427768C>T	uc001uvw.2	-	6	1391	c.1048G>A	c.(1048-1050)GTG>ATG	p.V350M	SMAD9_uc001uvx.2_Missense_Mutation_p.V313M|SMAD9_uc010tep.1_Missense_Mutation_p.V143M	NM_001127217	NP_001120689	O15198	SMAD9_HUMAN	SMAD family member 9 isoform a	350	MH2.				BMP signaling pathway|transforming growth factor beta receptor signaling pathway	cytosol|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.38e-07)|Epithelial(112;1.93e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00804)|BRCA - Breast invasive adenocarcinoma(63;0.0129)|GBM - Glioblastoma multiforme(144;0.026)		CTGTCACTCACGCACTCGGCA	0.562													6	43					0	0	0.248553	0	0
MYCBP2	23077	broad.mit.edu	37	13	77714188	77714188	+	Missense_Mutation	SNP	A	C	C			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr13:77714188A>C	uc001vkf.2	-	52	7489	c.7398T>G	c.(7396-7398)ATT>ATG	p.I2466M	MYCBP2_uc010aev.2_Missense_Mutation_p.I1870M	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	2466					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TTACCTCATCAATAAAAGTGA	0.398													4	78					0	0	0.184627	0	0
TC2N	123036	broad.mit.edu	37	14	92268745	92268745	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr14:92268745C>T	uc001xzu.3	-	4	513	c.322G>A	c.(322-324)GGA>AGA	p.G108R	TC2N_uc001xzt.3_Missense_Mutation_p.G108R|TC2N_uc010auc.2_Missense_Mutation_p.G108R|TC2N_uc001xzv.3_Missense_Mutation_p.G108R	NM_001128595	NP_001122067	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	108						nucleus				upper_aerodigestive_tract(1)	1				COAD - Colon adenocarcinoma(157;0.218)		TTTCGATCTCCAAAAGATGCT	0.403													15	61					0	0	0.457914	0	0
ADAM6	8755	broad.mit.edu	37	14	106974602	106974602	+	RNA	SNP	C	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr14:106974602C>T	uc010tyt.1	-	197		c.8759G>A								Parts of antibodies, mostly variable regions.												0						GATGGTGAATCGGCCCATCAC	0.512													13	81					0	0	0.411799	0	0
DYX1C1	161582	broad.mit.edu	37	15	55742505	55742505	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr15:55742505C>T	uc002adc.2	-	6	1066	c.698G>A	c.(697-699)CGC>CAC	p.R233H	CCPG1_uc002acy.2_5'UTR|DYX1C1_uc010ugh.1_RNA|DYX1C1_uc010ugi.1_RNA|DYX1C1_uc002adb.2_Missense_Mutation_p.R233H|DYX1C1_uc002add.2_Missense_Mutation_p.R233H	NM_130810	NP_570722	Q8WXU2	DYXC1_HUMAN	dyslexia susceptibility 1 candidate 1 isoform a	233					neuron migration|regulation of estrogen receptor signaling pathway|regulation of proteasomal protein catabolic process	cytoplasm|nucleus	estrogen receptor binding			skin(1)	1				all cancers(107;0.0118)|GBM - Glioblastoma multiforme(80;0.171)		GCCAACAGAGCGAGGAGCAGG	0.378													32	62					0	0	0.750413	0	0
ALDH1A3	220	broad.mit.edu	37	15	101447398	101447398	+	Missense_Mutation	SNP	G	A	A	rs145630728	byFrequency	TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr15:101447398G>A	uc002bwn.3	+	11	1410	c.1306G>A	c.(1306-1308)GAC>AAC	p.D436N	ALDH1A3_uc010bpb.2_Missense_Mutation_p.D329N|uc002bwo.1_Intron	NM_000693	NP_000684	P47895	AL1A3_HUMAN	aldehyde dehydrogenase 1A3	436					retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity			central_nervous_system(2)|lung(1)|pancreas(1)	4	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)	GAATAGCACCGACTATGGACT	0.438													68	40					0	0	0.870114	0	0
TNRC6A	27327	broad.mit.edu	37	16	24802981	24802982	+	Missense_Mutation	DNP	AG	CC	CC			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr16:24802981_24802982AG>CC	uc002dmm.2	+	6	3132_3133	c.3018_3019AG>CC	c.(3016-3021)TCAGCT>TCCCCT	p.A1007P	TNRC6A_uc010bxs.2_Missense_Mutation_p.A754P|TNRC6A_uc010vcc.1_Missense_Mutation_p.A754P|TNRC6A_uc002dmn.2_Missense_Mutation_p.A754P|TNRC6A_uc002dmo.2_Missense_Mutation_p.A754P	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1007	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		ATGGAACTTCAGCTTGGGGAGA	0.47													23	57					0	0	0.115264	0	0
TP53	7157	broad.mit.edu	37	17	7577538	7577538	+	Missense_Mutation	SNP	C	T	T	rs11540652		TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			39	45					0	0	0.840704	0	0
NEK8	284086	broad.mit.edu	37	17	27068158	27068158	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr17:27068158C>T	uc002hcp.2	+	13	1795	c.1795C>T	c.(1795-1797)CGA>TGA	p.R599*	TRAF4_uc002hcq.1_5'Flank|TRAF4_uc002hcs.2_5'Flank	NM_178170	NP_835464	Q86SG6	NEK8_HUMAN	NIMA-related kinase 8	599	RCC1 4.					cytoplasm|primary cilium	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|pancreas(1)|liver(1)|skin(1)	6	Lung NSC(42;0.0158)					CAATACTCGCCGAGGCAGTCG	0.572													24	109					0	0	0.693898	0	0
MUC16	94025	broad.mit.edu	37	19	9082521	9082521	+	Missense_Mutation	SNP	C	A	A			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr19:9082521C>A	uc002mkp.2	-	1	9498	c.9294G>T	c.(9292-9294)CAG>CAT	p.Q3098H		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3099	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGCAATGGTCTGGCTTGAGG	0.478													44	248					3.40343e-31	3.7644e-31	0.870114	1	0
KANK2	25959	broad.mit.edu	37	19	11303539	11303539	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr19:11303539C>T	uc010dxv.2	-	6	1775	c.1217G>A	c.(1216-1218)AGC>AAC	p.S406N	KANK2_uc002mqm.2_Missense_Mutation_p.S406N|KANK2_uc002mqo.3_Missense_Mutation_p.S406N|KANK2_uc002mqp.1_Missense_Mutation_p.S215N|KANK2_uc002mqq.2_Missense_Mutation_p.S406N	NM_015493	NP_056308	Q63ZY3	KANK2_HUMAN	ankyrin repeat domain 25 isoform 1	406											0						CTCTGTGATGCTAATCTTCTT	0.612													18	88					0	0	0.624587	0	0
ZNF20	7568	broad.mit.edu	37	19	12244606	12244606	+	Missense_Mutation	SNP	G	A	A			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr19:12244606G>A	uc002mtf.1	-	4	538	c.395C>T	c.(394-396)TCA>TTA	p.S132L	ZNF20_uc002mte.1_Missense_Mutation_p.S97L|ZNF20_uc002mtg.1_Missense_Mutation_p.S132L	NM_021143	NP_066966	P17024	ZNF20_HUMAN	zinc finger protein 20	132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATACTCAGATGACTTGTGTCC	0.408													59	231					0	0	0.870114	0	0
SLC1A6	6511	broad.mit.edu	37	19	15073101	15073101	+	Silent	SNP	G	A	A	rs150916469	byFrequency	TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr19:15073101G>A	uc002naa.1	-	5	656	c.648C>T	c.(646-648)AAC>AAT	p.N216N	SLC1A6_uc010dzu.1_Silent_p.N216N|SLC1A6_uc010xod.1_Silent_p.N152N|SLC1A6_uc002nab.2_Silent_p.N216N|SLC1A6_uc002nac.2_Silent_p.N216N	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	216	Extracellular (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	GCTCAGACCCGTTCTCTGTCC	0.517													41	139					0	0	0.870114	0	0
HNRNPL	3191	broad.mit.edu	37	19	39328114	39328114	+	Missense_Mutation	SNP	G	A	A			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr19:39328114G>A	uc010xul.1	-	12	1632	c.1621C>T	c.(1621-1623)CGC>TGC	p.R541C	HNRNPL_uc010ege.1_Missense_Mutation_p.R89C|HNRNPL_uc002ojj.1_Missense_Mutation_p.R197C|HNRNPL_uc002ojo.1_Missense_Mutation_p.R119C|HNRNPL_uc002ojk.2_Missense_Mutation_p.R197C|HNRNPL_uc002ojl.2_Missense_Mutation_p.R197C|HNRNPL_uc010xum.1_Missense_Mutation_p.R408C	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	541					nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			GAGGAGCTGCGCTCACCTGAT	0.512													42	78					0	0	0.840704	0	0
ZNF845	91664	broad.mit.edu	37	19	53854880	53854880	+	Missense_Mutation	SNP	A	G	G			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr19:53854880A>G	uc010ydv.1	+	4	1069	c.952A>G	c.(952-954)AAG>GAG	p.K318E	ZNF845_uc010ydw.1_Missense_Mutation_p.K318E	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	318	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGTAATTCATAAGGCAATTCA	0.413													41	67					0	0	0.834066	0	0
NLRP4	147945	broad.mit.edu	37	19	56369610	56369610	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr19:56369610C>T	uc002qmd.3	+	3	1273	c.851C>T	c.(850-852)CCG>CTG	p.P284L	NLRP4_uc002qmf.2_Missense_Mutation_p.P209L|NLRP4_uc010etf.2_Missense_Mutation_p.P115L	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	284	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CCCGTGTGCCCGAAGGAGCTC	0.537													29	142					0	0	0.717897	0	0
ZNF71	58491	broad.mit.edu	37	19	57132875	57132875	+	Missense_Mutation	SNP	G	A	A	rs141566979	byFrequency	TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr19:57132875G>A	uc002qnm.3	+	3	458	c.220G>A	c.(220-222)GCA>ACA	p.A74T		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	74						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		CTCAGTACCCGCATGTCATGA	0.617													11	68					0	0	0.411799	0	0
EFEMP1	2202	broad.mit.edu	37	2	56145171	56145171	+	Missense_Mutation	SNP	T	C	C	rs55849640	byFrequency	TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr2:56145171T>C	uc002rzh.2	-	4	476	c.146A>G	c.(145-147)GAC>GGC	p.D49G	EFEMP1_uc002rzi.2_Missense_Mutation_p.D49G|EFEMP1_uc002rzj.2_Missense_Mutation_p.D49G|EFEMP1_uc010ypc.1_5'UTR	NM_004105	NP_004096	Q12805	FBLN3_HUMAN	EGF-containing fibulin-like extracellular matrix	49	EGF-like 1; atypical.				negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			ovary(4)|pancreas(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TGGGACAATGTCACATTCATC	0.373													32	76					0	0	0.769981	0	0
DCTN1	1639	broad.mit.edu	37	2	74595916	74595916	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr2:74595916C>T	uc002skx.2	-	16	2104	c.1793G>A	c.(1792-1794)CGG>CAG	p.R598Q	DCTN1_uc002skv.2_Missense_Mutation_p.R464Q|DCTN1_uc002sku.2_Missense_Mutation_p.R464Q|DCTN1_uc002skw.1_Missense_Mutation_p.R574Q|DCTN1_uc010ffd.2_Missense_Mutation_p.R578Q|DCTN1_uc002sky.2_Missense_Mutation_p.R561Q	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	598					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5						CCCACCTGGCCGAAGGAAGCT	0.498													17	103					0	0	0.575678	0	0
VWA3B	200403	broad.mit.edu	37	2	98928738	98928738	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr2:98928738C>T	uc002syo.2	+	28	4075	c.3811C>T	c.(3811-3813)CGA>TGA	p.R1271*	VWA3B_uc002syr.1_3'UTR|VWA3B_uc002sys.2_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	1271										ovary(3)|large_intestine(2)|skin(1)	6						ACCTCCACCTCGAGCAGCCCT	0.607													21	76					0	0	0.608945	0	0
SCN3A	6328	broad.mit.edu	37	2	165970378	165970378	+	Missense_Mutation	SNP	T	C	C			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr2:165970378T>C	uc002ucx.2	-	20	4109	c.3617A>G	c.(3616-3618)AAC>AGC	p.N1206S	SCN3A_uc002ucy.2_Missense_Mutation_p.N1157S|SCN3A_uc002ucz.2_Missense_Mutation_p.N1157S|SCN3A_uc002uda.1_Missense_Mutation_p.N1026S|SCN3A_uc002udb.1_Missense_Mutation_p.N1026S	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1206	Helical; Name=S1 of repeat III; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	CTCAAACCAGTTGTGCTCAAC	0.378													40	135					0	0	0.864702	0	0
KBTBD10	10324	broad.mit.edu	37	2	170374777	170374777	+	Missense_Mutation	SNP	G	A	A			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr2:170374777G>A	uc002ueu.1	+	4	1531	c.1454G>A	c.(1453-1455)CGT>CAT	p.R485H	KBTBD10_uc010zdh.1_Missense_Mutation_p.R423H	NM_006063	NP_006054	O60662	KBTBA_HUMAN	kelch repeat and BTB (POZ) domain containing 10	485	Kelch 3.				striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle					0						AAAATTCCTCGTTCCATGTTT	0.388													9	77					0	0	0.387290	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 								27	36					0	0	0.717897	0	0
COL4A3	1285	broad.mit.edu	37	2	228153927	228153927	+	Silent	SNP	G	A	A			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr2:228153927G>A	uc002vom.1	+	35	3105	c.2943G>A	c.(2941-2943)AAG>AAA	p.K981K	COL4A3_uc002von.1_Silent_p.K981K|COL4A3_uc002voo.1_Silent_p.K981K|COL4A3_uc002vop.1_Silent_p.K981K|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	981	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		CAGGTTTAAAGGGCCTCAAAG	0.408													3	52					0	0	0.150653	0	0
NSFL1C	55968	broad.mit.edu	37	20	1426390	1426390	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr20:1426390C>T	uc002wfc.2	-	8	1819	c.871G>A	c.(871-873)GAA>AAA	p.E291K	NSFL1C_uc002wfd.2_Missense_Mutation_p.E180K|NSFL1C_uc002wfe.2_Missense_Mutation_p.E260K|NSFL1C_uc002wff.2_RNA|NSFL1C_uc010gag.2_Missense_Mutation_p.E57K	NM_016143	NP_057227	Q9UNZ2	NSF1C_HUMAN	p47 protein isoform a	291	UBX.					chromosome|Golgi stack|nucleus	lipid binding|protein binding				0						GGCTCTGATTCGTCGATTAAG	0.532													17	257					0	0	0.557998	0	0
ATP5O	539	broad.mit.edu	37	21	35288047	35288047	+	Silent	SNP	G	A	A			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr21:35288047G>A	uc002ytl.2	-	1	112	c.21C>T	c.(19-21)TCC>TCT	p.S7S	ATP5O_uc002ytm.1_5'Flank	NM_001697	NP_001688	P48047	ATPO_HUMAN	mitochondrial ATP synthase, O subunit precursor	7					ATP catabolic process|mitochondrial ATP synthesis coupled proton transport|respiratory electron transport chain	mitochondrial proton-transporting ATP synthase complex|plasma membrane|proton-transporting ATP synthase complex, catalytic core F(1)	drug binding|hydrogen ion transporting ATP synthase activity, rotational mechanism			ovary(1)	1						GGGAGAGCCCGGACACTGCTG	0.652													5	4					0	0	0.184627	0	0
C3orf18	51161	broad.mit.edu	37	3	50598380	50598380	+	Missense_Mutation	SNP	C	A	A			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr3:50598380C>A	uc003das.2	-	4	827	c.376G>T	c.(376-378)GCT>TCT	p.A126S	C3orf18_uc003dar.2_Missense_Mutation_p.A126S|C3orf18_uc011bdr.1_RNA|C3orf18_uc010hlo.2_Missense_Mutation_p.A106S|C3orf18_uc010hlp.2_Intron|C3orf18_uc003dat.2_Missense_Mutation_p.A126S	NM_016210	NP_057294	Q9UK00	CC018_HUMAN	hypothetical protein LOC51161	126						integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.0175)|Kidney(197;0.0207)		GAAGTAGCAGCCTGTACAGAG	0.637													24	56					3.28513e-13	3.52668e-13	0.667858	1	0
ANKRD17	26057	broad.mit.edu	37	4	73957066	73957066	+	Silent	SNP	T	A	A			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr4:73957066T>A	uc003hgp.2	-	29	6396	c.6279A>T	c.(6277-6279)CCA>CCT	p.P2093P	ANKRD17_uc003hgo.2_Silent_p.P1980P|ANKRD17_uc003hgq.2_Silent_p.P1842P|ANKRD17_uc003hgr.2_Silent_p.P2092P	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	2093	Ser-rich.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGCTGCTGTTTGGAGGTCTAG	0.473													48	141					0	0	0.870114	0	0
PRDM9	56979	broad.mit.edu	37	5	23527687	23527687	+	Silent	SNP	G	A	A			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr5:23527687G>A	uc003jgo.2	+	11	2672	c.2490G>A	c.(2488-2490)AAG>AAA	p.K830K		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	830					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						CAGGGGAGAAGCCCTATGTCT	0.587										HNSCC(3;0.000094)			28	95					0	0	0.760397	0	0
Unknown	0	broad.mit.edu	37	5	28927406	28927406	+	RNA	SNP	G	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr5:28927406G>T	uc003jgz.1	+	1		c.430G>T								Homo sapiens similar to Striatin, mRNA (cDNA clone MGC:150339 IMAGE:40119616), complete cds.																		TCATGATAACGTGAACAGAAG	0.423													18	47					1.02788e-11	1.07194e-11	0.520397	1	0
FAM174A	345757	broad.mit.edu	37	5	99897847	99897847	+	Missense_Mutation	SNP	A	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr5:99897847A>T	uc003knj.1	+	2	644	c.524A>T	c.(523-525)GAT>GTT	p.D175V		NM_198507	NP_940909	Q8TBP5	F174A_HUMAN	family with sequence similarity 174, member A	175	Cytoplasmic (Potential).					integral to membrane					0						GAACAGGATGATGAGGATGAT	0.383													29	61					0	0	0.740014	0	0
ZFP57	346171	broad.mit.edu	37	6	29641322	29641322	+	Missense_Mutation	SNP	T	A	A			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr6:29641322T>A	uc011dlw.1	-	4	717	c.566A>T	c.(565-567)TAC>TTC	p.Y189F	ZFP57_uc003nnl.3_Missense_Mutation_p.Y169F	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	105	C2H2-type 1.				DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						GCTATAGAGGTAGGAGCGCCT	0.542													24	95					0	0	0.654019	0	0
RSPH9	221421	broad.mit.edu	37	6	43612865	43612865	+	Silent	SNP	G	A	A			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr6:43612865G>A	uc003ovw.1	+	1	56	c.30G>A	c.(28-30)CTG>CTA	p.L10L	RSPH9_uc003ovx.1_Silent_p.L10L	NM_152732	NP_689945	Q9H1X1	RSPH9_HUMAN	radial spoke head 9 homolog	10					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton				upper_aerodigestive_tract(1)|skin(1)	2						TGCTGTCTCTGGAGCTGGCGT	0.657									Kartagener_syndrome				7	53					0	0	0.307466	0	0
GJA1	2697	broad.mit.edu	37	6	121769068	121769068	+	Missense_Mutation	SNP	G	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr6:121769068G>T	uc003pyr.2	+	2	1325	c.1075G>T	c.(1075-1077)GTG>TTG	p.V359L	GJA1_uc011ebo.1_Missense_Mutation_p.V260L|GJA1_uc011ebp.1_Missense_Mutation_p.V147L	NM_000165	NP_000156	P17302	CXA1_HUMAN	connexin 43	359	Cytoplasmic (Potential).				cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			ovary(2)	2				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)	ACTAGCCATTGTGGACCAGCG	0.493													29	119					4.65686e-17	5.0739e-17	0.788014	1	0
MAP7	9053	broad.mit.edu	37	6	136683671	136683671	+	Missense_Mutation	SNP	C	A	A			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr6:136683671C>A	uc003qgz.2	-	11	1689	c.1443G>T	c.(1441-1443)AGG>AGT	p.R481S	MAP7_uc011edf.1_Missense_Mutation_p.R466S|MAP7_uc011edg.1_Missense_Mutation_p.R511S|MAP7_uc010kgu.2_Missense_Mutation_p.R503S|MAP7_uc011edh.1_Missense_Mutation_p.R466S|MAP7_uc010kgv.2_Missense_Mutation_p.R503S|MAP7_uc010kgs.2_Missense_Mutation_p.R335S|MAP7_uc011edi.1_Missense_Mutation_p.R335S|MAP7_uc010kgq.1_Missense_Mutation_p.R387S|MAP7_uc003qha.1_Missense_Mutation_p.R444S	NM_003980	NP_003971	Q14244	MAP7_HUMAN	microtubule-associated protein 7	481	Potential.				establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		CAGCTAGAAGCCTTGTGGCCT	0.468													17	57					3.51602e-12	3.71984e-12	0.575678	1	0
REPS1	85021	broad.mit.edu	37	6	139247539	139247539	+	Missense_Mutation	SNP	G	C	C			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr6:139247539G>C	uc003qii.2	-	10	1916	c.1337C>G	c.(1336-1338)CCT>CGT	p.P446R	REPS1_uc003qig.3_Intron|REPS1_uc011edr.1_Missense_Mutation_p.P446R|REPS1_uc003qij.2_Intron|REPS1_uc003qik.2_Intron	NM_031922	NP_114128	Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	446						coated pit|plasma membrane	calcium ion binding|SH3 domain binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)		TTGACTTACAGGATCAGCTGG	0.393													12	12					0	0	0.387290	0	0
MLXIPL	51085	broad.mit.edu	37	7	73011230	73011230	+	Missense_Mutation	SNP	C	G	G			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr7:73011230C>G	uc003tyn.1	-	10	1684	c.1636G>C	c.(1636-1638)GTA>CTA	p.V546L	MLXIPL_uc003tyj.1_5'UTR|MLXIPL_uc003tyk.1_Missense_Mutation_p.V546L|MLXIPL_uc003tyl.1_Missense_Mutation_p.V546L|MLXIPL_uc003tym.1_Missense_Mutation_p.V546L|MLXIPL_uc003tyo.1_RNA|MLXIPL_uc003typ.1_Missense_Mutation_p.V453L|MLXIPL_uc003tyq.1_Missense_Mutation_p.V288L	NM_032951	NP_116569	Q9NP71	WBS14_HUMAN	Williams Beuren syndrome chromosome region 14	546					anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				GTGCTGGATACAAGTGGTGGC	0.672													2	23					0	0	0.115264	0	0
C8orf74	203076	broad.mit.edu	37	8	10557893	10557893	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr8:10557893C>T	uc003wtd.1	+	4	826	c.797C>T	c.(796-798)CCG>CTG	p.P266L	C8orf74_uc003wte.1_RNA	NM_001040032	NP_001035121	Q6P047	CH074_HUMAN	hypothetical protein LOC203076	266											0				COAD - Colon adenocarcinoma(149;0.0811)		ACCCCTATCCCGCCCCCCATC	0.587													19	19					0	0	0.557998	0	0
FLJ46321	389763	broad.mit.edu	37	9	84606491	84606491	+	Missense_Mutation	SNP	C	G	G			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr9:84606491C>G	uc004amn.2	+	4	1153	c.1106C>G	c.(1105-1107)TCT>TGT	p.S369C		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	369						integral to membrane					0						TCTTTTTCCTCTAATTTTGTG	0.483													15	69					0	0	0.500413	0	0
TGFBR1	7046	broad.mit.edu	37	9	101907133	101907133	+	Missense_Mutation	SNP	A	G	G			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr9:101907133A>G	uc004azc.2	+	6	1169	c.1093A>G	c.(1093-1095)ATT>GTT	p.I365V	TGFBR1_uc004azd.2_Missense_Mutation_p.I288V|TGFBR1_uc011lvc.1_Missense_Mutation_p.I296V	NM_004612	NP_004603	P36897	TGFR1_HUMAN	transforming growth factor, beta receptor I	365	Protein kinase.|Cytoplasmic (Potential).				activation of MAPKK activity|anterior/posterior pattern formation|artery morphogenesis|collagen fibril organization|embryonic cranial skeleton morphogenesis|germ cell migration|heart development|kidney development|neuron fate commitment|palate development|parathyroid gland development|pathway-restricted SMAD protein phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|pharyngeal system development|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of cellular component movement|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of SMAD protein import into nucleus|positive regulation of survival gene product expression|positive regulation of transcription, DNA-dependent|response to cholesterol|thymus development|transforming growth factor beta receptor signaling pathway		ATP binding|I-SMAD binding|metal ion binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type I|type II transforming growth factor beta receptor binding			lung(2)|ovary(1)	3		Acute lymphoblastic leukemia(62;0.0559)				CACAGATACCATTGATATTGC	0.348													5	94					0	0	0.184627	0	0
C9orf96	169436	broad.mit.edu	37	9	136256485	136256485	+	Missense_Mutation	SNP	A	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr9:136256485A>T	uc004cdk.2	+	7	557	c.496A>T	c.(496-498)ATC>TTC	p.I166F	C9orf96_uc004cdl.2_Intron	NM_153710	NP_714921	Q8NE28	SGK71_HUMAN	hypothetical protein LOC169436	166	Protein kinase.						ATP binding|protein kinase activity			stomach(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		CATCATCCTCATCAGCAGTGA	0.552													78	316					0	0	0.870114	0	0
BEND2	139105	broad.mit.edu	37	X	18234679	18234679	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chrX:18234679C>T	uc004cyj.3	-	2	354	c.200G>A	c.(199-201)GGC>GAC	p.G67D	BEND2_uc010nfb.2_Missense_Mutation_p.G67D	NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	67										ovary(3)|kidney(1)|central_nervous_system(1)	5						GCCATCATTGCCGCCTGGAAA	0.408													38	6					0	0	0.847076	0	0
ATRX	546	broad.mit.edu	37	X	76940083	76940083	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chrX:76940083C>T	uc004ecp.3	-	9	897	c.665G>A	c.(664-666)TGG>TAG	p.W222*	ATRX_uc004ecq.3_Nonsense_Mutation_p.W184*|ATRX_uc004eco.3_Nonsense_Mutation_p.W7*|ATRX_uc004ecr.2_Nonsense_Mutation_p.W183*|ATRX_uc010nlx.1_Nonsense_Mutation_p.W222*|ATRX_uc010nly.1_Nonsense_Mutation_p.W167*	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	222	ADD.|PHD-type; atypical.		W -> S (in ATRX).		DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTCCGCACACCACCTGAAATG	0.343			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						81	13					0	0	0.870114	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72493665	72493665	+	Frame_Shift_Del	DEL	G	-	-			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr10:72493665delG	uc001jrh.2	+	8	1233	c.1233delG	c.(1231-1233)CAGfs	p.Q411fs	ADAMTS14_uc001jrg.2_Frame_Shift_Del_p.Q414fs|ADAMTS14_uc001jri.1_5'Flank	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	411	Peptidase M12B.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						ATGACGGTCAGGGGAATGGCT	0.577													19	93	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7579694	7579699	+	Splice_Site	DEL	CCTTAC	-	-			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr17:7579694_7579699delCCTTAC	uc002gim.2	-	3	290	c.96_splice	c.e3+1	p.L32_splice	TP53_uc002gig.1_Splice_Site_p.L32_splice|TP53_uc002gih.2_Splice_Site_p.L32_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Splice_Site_p.L32_splice|TP53_uc010cni.1_Splice_Site_p.L32_splice|TP53_uc002gij.2_Splice_Site_p.L32_splice|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Splice_Site_p.L32_splice|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Splice_Site|TP53_uc010cnk.1_Splice_Site_p.L47_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.?(2)|p.S33fs*10(1)|p.P13fs*18(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		cAACCCTTGTCCTTACCAGAACGTTG	0.379		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	46	---	---	---	---					
R3HDM1	23518	broad.mit.edu	37	2	136389572	136389575	+	Splice_Site	DEL	GTAA	-	-			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr2:136389572_136389575delGTAA	uc002tuo.2	+	9	1068	c.698_splice	c.e9+1	p.I233_splice	R3HDM1_uc010fni.2_Splice_Site_p.I231_splice|R3HDM1_uc002tup.2_Splice_Site_p.I177_splice|R3HDM1_uc010zbh.1_Splice_Site_p.I65_splice	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1								nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		ATACAAGAATGTAAGTGTCAAGAG	0.324													29	106	---	---	---	---					
SPOCK3	50859	broad.mit.edu	37	4	167810286	167810287	+	Frame_Shift_Del	DEL	TT	-	-			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr4:167810286_167810287delTT	uc003iri.1	-	7	733_734	c.592_593delAA	c.(592-594)AAGfs	p.K198fs	SPOCK3_uc011cjp.1_Frame_Shift_Del_p.K195fs|SPOCK3_uc011cjq.1_Frame_Shift_Del_p.K207fs|SPOCK3_uc011cjr.1_Frame_Shift_Del_p.K78fs|SPOCK3_uc003irj.1_Frame_Shift_Del_p.K195fs|SPOCK3_uc011cjs.1_Frame_Shift_Del_p.K147fs|SPOCK3_uc011cjt.1_Frame_Shift_Del_p.K106fs|SPOCK3_uc011cju.1_Frame_Shift_Del_p.K91fs|SPOCK3_uc011cjv.1_Frame_Shift_Del_p.K100fs|SPOCK3_uc003irk.3_Frame_Shift_Del_p.K195fs|SPOCK3_uc011cjw.1_RNA	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	198					signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		CTTACCTCTCTTAACATTTCTG	0.337													33	80	---	---	---	---					
GFPT2	9945	broad.mit.edu	37	5	179744060	179744061	+	Splice_Site	DEL	TG	-	-			TCGA-DB-5281-01A-01D-1468-08	TCGA-DB-5281-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	ccf3d939-7964-4cc0-b2f6-e7cb8ee026a1	b8f9db26-3096-4ad2-9b45-530bccdc8612	g.chr5:179744060_179744061delTG	uc003mlw.1	-	11	1057	c.959_splice	c.e11-1	p.G320_splice		NM_005110	NP_005101	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2						dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			ovary(1)|skin(1)	2	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	TGAAGTTACCTGGTCAAATAAA	0.322													27	103	---	---	---	---					
