Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MIB2	142678	broad.mit.edu	37	1	1560729	1560729	+	Missense_Mutation	SNP	A	G	G			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr1:1560729A>G	uc001agg.2	+	7	1086	c.959A>G	c.(958-960)AAG>AGG	p.K320R	MIB2_uc001agh.2_Missense_Mutation_p.K306R|MIB2_uc001agi.2_Missense_Mutation_p.K320R|MIB2_uc001agj.2_Missense_Mutation_p.K161R|MIB2_uc001agk.2_Missense_Mutation_p.K255R|MIB2_uc001agl.1_Missense_Mutation_p.K276R|MIB2_uc001agm.2_Missense_Mutation_p.K197R|MIB2_uc010nyq.1_Missense_Mutation_p.K276R|MIB2_uc009vkh.2_Missense_Mutation_p.K161R|MIB2_uc001agn.2_5'UTR	NM_080875	NP_543151	Q96AX9	MIB2_HUMAN	mindbomb homolog 2	320					Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CACGGGGACAAGGTCAAGTGT	0.697000													2	6					0	0	0.004672	0	0
GBP5	115362	broad.mit.edu	37	1	89728016	89728016	+	Missense_Mutation	SNP	C	T	T			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr1:89728016C>T	uc001dnc.2	-	11	2071	c.1534G>A	c.(1534-1536)GAG>AAG	p.E512K	GBP5_uc001dnd.2_Missense_Mutation_p.E512K	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	512						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		ATCATTTGCTCGTTCTGCCTT	0.463000													62	78					0	0	0.014410	0	0
FLG	2312	broad.mit.edu	37	1	152282227	152282227	+	Missense_Mutation	SNP	C	T	T			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr1:152282227C>T	uc001ezu.1	-	3	5171	c.5135G>A	c.(5134-5136)CGA>CAA	p.R1712Q		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1712	Ser-rich.|Filaggrin 10.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity	p.R1712P(1)		ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACTGGACCCTCGGTTTCCACT	0.592000									Ichthyosis				16	574					0	0	0.033300	0	0
PCNXL2	80003	broad.mit.edu	37	1	233344354	233344354	+	Missense_Mutation	SNP	C	T	T			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr1:233344354C>T	uc001hvl.2	-	13	3008	c.2773G>A	c.(2773-2775)GCC>ACC	p.A925T	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc001hvp.1_RNA|PCNXL2_uc009xfv.1_RNA|PCNXL2_uc001hvq.1_Missense_Mutation_p.A224T	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	925						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				CTGGCTTTGGCCCCTGTATCA	0.423000													14	91					0	0	0.016723	0	0
NLRP14	338323	broad.mit.edu	37	11	7064302	7064302	+	Missense_Mutation	SNP	G	A	A			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr11:7064302G>A	uc001mfb.1	+	4	1368	c.1045G>A	c.(1045-1047)GCC>ACC	p.A349T		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	349	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TAAGAGGTGGGCCATGAAAGT	0.428000													26	202					0	0	0.024334	0	0
CREB3L1	90993	broad.mit.edu	37	11	46332655	46332655	+	Missense_Mutation	SNP	G	A	A			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr11:46332655G>A	uc001ncf.2	+	5	1103	c.668G>A	c.(667-669)CGC>CAC	p.R223H		NM_052854	NP_443086	Q96BA8	CR3L1_HUMAN	cAMP responsive element binding protein 3-like	223	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L1(6)	soft_tissue(6)|ovary(2)	8				GBM - Glioblastoma multiforme(35;0.0285)		CAGAGTCCCCGCTCTCTGCCC	0.687000			T	FUS	myxofibrosarcoma								5	88					0	0	0.014758	0	0
AHNAK	79026	broad.mit.edu	37	11	62289982	62289982	+	Silent	SNP	G	A	A			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr11:62289982G>A	uc001ntl.2	-	5	12207	c.11907C>T	c.(11905-11907)GAC>GAT	p.D3969D	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3969					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GAACATCAACGTCCACCTTGG	0.498000													45	553					0	0	0.014410	0	0
CATSPER1	117144	broad.mit.edu	37	11	65790440	65790440	+	Missense_Mutation	SNP	G	A	A			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr11:65790440G>A	uc001ogt.2	-	2	1447	c.1309C>T	c.(1309-1311)CGG>TGG	p.R437W		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	sperm-associated cation channel 1	437	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			ovary(2)	2						ATCATTTCCCGGAAGCCCTGA	0.557000											OREG0021092	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	70	109					0	0	0.014410	0	0
MYO7A	4647	broad.mit.edu	37	11	76922334	76922334	+	Silent	SNP	G	A	A			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr11:76922334G>A	uc001oyb.2	+	45	6461	c.6189G>A	c.(6187-6189)CTG>CTA	p.L2063L	MYO7A_uc001oyc.2_Silent_p.L2025L|MYO7A_uc001oye.2_RNA	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	2063	FERM 2.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						TGCGGGAGCTGGTGCCCCAGG	0.652000													2	5					0	0	0.004672	0	0
PICALM	8301	broad.mit.edu	37	11	85692181	85692181	+	Silent	SNP	A	C	C	rs76719109	byFrequency	TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr11:85692181A>C	uc001pbm.2	-	17	2056	c.1770T>G	c.(1768-1770)GCT>GCG	p.A590A	PICALM_uc001pbl.2_Silent_p.A540A|PICALM_uc001pbn.2_Silent_p.A583A|PICALM_uc010rtl.1_Silent_p.A489A|PICALM_uc001pbk.2_RNA|PICALM_uc010rtk.1_Silent_p.A167A|PICALM_uc001pbo.1_Silent_p.A222A	NM_007166	NP_009097	Q13492	PICAL_HUMAN	phosphatidylinositol-binding clathrin assembly	590					clathrin coat assembly|endosome transport|negative regulation of receptor-mediated endocytosis|positive regulation of transcription, DNA-dependent|receptor internalization|regulation of protein localization	clathrin coat|clathrin-coated vesicle|coated pit|Golgi apparatus|nucleus|postsynaptic membrane|presynaptic membrane	1-phosphatidylinositol binding|clathrin heavy chain binding	p.A590A(1)		urinary_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(157;7.42e-07)|all_hematologic(158;0.00092)				CCATTGTTGCAGCATTCCAAG	0.343000			T	MLLT10|MLL	TALL|AML|								6	201					0	0	0.021553	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54914539	54914539	+	Missense_Mutation	SNP	C	T	T			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr12:54914539C>T	uc001sgc.3	+	17	1766	c.1687C>T	c.(1687-1689)CGT>TGT	p.R563C	NCKAP1L_uc010sox.1_Missense_Mutation_p.R105C|NCKAP1L_uc010soy.1_Missense_Mutation_p.R513C	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	563					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						TGCCATGTTGCGTTATGCCAT	0.463000													222	439					0	0	0.014410	0	0
LGR5	8549	broad.mit.edu	37	12	71978453	71978453	+	Missense_Mutation	SNP	C	T	T			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr12:71978453C>T	uc001swl.2	+	18	2711	c.2663C>T	c.(2662-2664)CCA>CTA	p.P888L	LGR5_uc001swm.2_Missense_Mutation_p.P864L|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	888	Cytoplasmic (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						GTGCCATCACCAGCTTATCCA	0.458000													86	177					0	0	0.014410	0	0
IDH2	3418	broad.mit.edu	37	15	90631838	90631838	+	Missense_Mutation	SNP	C	T	T	rs121913503		TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr15:90631838C>T	uc002box.2	-	4	601	c.515G>A	c.(514-516)AGG>AAG	p.R172K	IDH2_uc010uqb.1_Missense_Mutation_p.R120K|IDH2_uc010uqc.1_Missense_Mutation_p.R42K|IDH2_uc010bnu.2_Intron	NM_002168	NP_002159	P48735	IDHP_HUMAN	isocitrate dehydrogenase 2 (NADP+),	172		Substrate (By similarity).			2-oxoglutarate metabolic process|glyoxylate cycle|isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding	p.R172K(170)|p.R172M(21)|p.R172S(12)|p.R172W(7)|p.R172?(7)|p.R172G(2)		haematopoietic_and_lymphoid_tissue(621)|central_nervous_system(80)|bone(7)|skin(3)	711	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.106)			ATGGGCGTGCCTGCCAATGGT	0.632000			M		GBM								51	71					0	0	0.014410	0	0
CHMP1A	5119	broad.mit.edu	37	16	89715806	89715806	+	Missense_Mutation	SNP	C	T	T			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr16:89715806C>T	uc002fnu.2	-	4	338	c.205G>A	c.(205-207)GTA>ATA	p.V69I	CHMP1A_uc002fnt.2_5'Flank|CHMP1A_uc002fnv.2_Missense_Mutation_p.R62H	NM_002768	NP_002759	Q9HD42	CHM1A_HUMAN	chromatin modifying protein 1A isoform 2	69					cell division|gene silencing|mitotic chromosome condensation|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription by glucose|protein transport|transcription, DNA-dependent|vesicle-mediated transport	condensed nuclear chromosome|early endosome|endomembrane system|endosome membrane|microtubule organizing center|nuclear matrix	metallopeptidase activity|protein domain specific binding|zinc ion binding				0		all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.048)		ACTGCGTCTACGCGGGACGCC	0.597000													67	137					0	0	0.014410	0	0
RAB11FIP4	84440	broad.mit.edu	37	17	29855551	29855551	+	Missense_Mutation	SNP	C	T	T			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr17:29855551C>T	uc002hgn.1	+	12	1713	c.1484C>T	c.(1483-1485)GCG>GTG	p.A495V	RAB11FIP4_uc002hgo.2_Missense_Mutation_p.A393V	NM_032932	NP_116321	Q86YS3	RFIP4_HUMAN	RAB11 family interacting protein 4 (class II)	495	Potential.|Necessary for interaction with RAB11A, subcellular location, homo- or heterooligomerization.				cytokinesis|interspecies interaction between organisms|protein transport	cleavage furrow|endocytic vesicle|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			skin(1)	1		all_cancers(10;3.62e-13)|all_epithelial(10;0.000387)|all_lung(9;0.0132)|Breast(31;0.014)|all_hematologic(16;0.015)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0259)|Ovarian(249;0.0423)|Lung NSC(157;0.066)				GAGCGGGAGGCGACGCAGGAG	0.612000													7	138					0	0	0.004482	0	0
KRT36	8689	broad.mit.edu	37	17	39642800	39642800	+	Missense_Mutation	SNP	G	A	A			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr17:39642800G>A	uc002hwt.2	-	7	1232	c.1232C>T	c.(1231-1233)ACG>ATG	p.T411M		NM_003771	NP_003762	O76013	KRT36_HUMAN	keratin 36	411	Tail.					intermediate filament	protein binding|structural constituent of epidermis				0		Breast(137;0.000286)				CTTGCATGCCGTGGCACAAGG	0.577000													4	25					0	0	0.014758	0	0
CDH20	28316	broad.mit.edu	37	18	59174700	59174700	+	Silent	SNP	G	A	A			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr18:59174700G>A	uc010dps.1	+	5	936	c.924G>A	c.(922-924)GAG>GAA	p.E308E	CDH20_uc002lif.2_Silent_p.E302E	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	308	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				TCAATGCAGAGATGAAATATA	0.433000													13	133					0	0	0.020292	0	0
SERPINB3	6317	broad.mit.edu	37	18	61323264	61323264	+	Missense_Mutation	SNP	A	C	C			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr18:61323264A>C	uc002lji.2	-	8	944	c.800T>G	c.(799-801)ATG>AGG	p.M267R	SERPINB4_uc002ljg.2_Intron|SERPINB3_uc010dqa.2_Missense_Mutation_p.M215R	NM_006919	NP_008850	P29508	SPB3_HUMAN	serine (or cysteine) proteinase inhibitor, clade	267					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TGTCCATTCCATCAATTTCTC	0.378000													26	115					0	0	0.030593	0	0
DMRTC2	63946	broad.mit.edu	37	19	42353197	42353197	+	Splice_Site	SNP	G	A	A			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr19:42353197G>A	uc002ors.2	+	6	712	c.629_splice	c.e6-1	p.G210_splice	DMRTC2_uc002orr.1_Splice_Site_p.G87_splice|DMRTC2_uc010xwe.1_Splice_Site_p.G210_splice	NM_001040283	NP_001035373	Q8IXT2	DMRTD_HUMAN	DMRT-like family C2						cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0						ATTCTTATTAGGCTTTGACCC	0.458000													6	181					0	0	0.029380	0	0
ZNF845	91664	broad.mit.edu	37	19	53856702	53856702	+	Missense_Mutation	SNP	G	A	A	rs150688663	by1000genomes	TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr19:53856702G>A	uc010ydv.1	+	4	2891	c.2774G>A	c.(2773-2775)CGT>CAT	p.R925H	ZNF845_uc010ydw.1_Missense_Mutation_p.R925H	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	925	C2H2-type 26.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAAACCTTCCGTCACAATTCA	0.363000													5	42					0	0	0.021553	0	0
ZNF513	130557	broad.mit.edu	37	2	27600997	27600997	+	Silent	SNP	A	C	C			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr2:27600997A>C	uc002rkk.2	-	4	1241	c.1041T>G	c.(1039-1041)GGT>GGG	p.G347G	ZNF513_uc002rkj.2_Silent_p.G285G	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	347					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCCACTGGCACCCCCTCCAG	0.662000													6	53					0	0	0.025465	0	0
C2orf71	388939	broad.mit.edu	37	2	29294007	29294007	+	Missense_Mutation	SNP	G	A	A			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr2:29294007G>A	uc002rmt.1	-	1	3121	c.3121C>T	c.(3121-3123)CCA>TCA	p.P1041S		NM_001029883	NP_001025054	A6NGG8	CB071_HUMAN	hypothetical protein LOC388939	1041	Pro-rich.				response to stimulus|visual perception	photoreceptor outer segment				skin(1)	1						GTGGTGGGTGGGCTTAGCACC	0.687000													38	83					0	0	0.030466	0	0
RIF1	55183	broad.mit.edu	37	2	152293371	152293371	+	Missense_Mutation	SNP	C	A	A			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr2:152293371C>A	uc002txm.2	+	12	1356	c.1226C>A	c.(1225-1227)ACT>AAT	p.T409N	RIF1_uc002txl.2_Missense_Mutation_p.T409N|RIF1_uc010fnv.1_Missense_Mutation_p.T373N|RIF1_uc002txn.2_Missense_Mutation_p.T409N|RIF1_uc002txo.2_Missense_Mutation_p.T409N|RIF1_uc010zby.1_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	409					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		GCCCCGGGAACTCCCCGAATG	0.418000													11	114					4.68919e-08	4.91248e-08	0.008291	1	0
CHRNA1	1134	broad.mit.edu	37	2	175614763	175614763	+	Missense_Mutation	SNP	C	T	T	rs137852804		TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr2:175614763C>T	uc002ujd.2	-	8	1066	c.988G>A	c.(988-990)GTC>ATC	p.V330I	uc002uiw.2_Intron|CHRNA1_uc002uje.2_Missense_Mutation_p.V305I	NM_001039523	NP_001034612	P02708	ACHA_HUMAN	nicotinic cholinergic receptor alpha 1 isoform a	330	Helical.		V -> I (in FCCMS; abnormally slow channel opening and closing resulting in abnormally brief current).		muscle cell homeostasis|neuromuscular junction development|neuromuscular process|neuromuscular synaptic transmission|neuron homeostasis|regulation of action potential in neuron|skeletal muscle contraction|skeletal muscle tissue growth	cell junction|cell surface|neuromuscular junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(2)|central_nervous_system(1)|skin(1)	4						GAGGCAATGACGAACACCATG	0.537000													9	139					0	0	0.006214	0	0
PCSK2	5126	broad.mit.edu	37	20	17434533	17434533	+	Silent	SNP	C	T	T			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr20:17434533C>T	uc002wpm.2	+	9	1352	c.1032C>T	c.(1030-1032)GAC>GAT	p.D344D	PCSK2_uc002wpl.2_Silent_p.D325D|PCSK2_uc010zrm.1_Silent_p.D309D	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	344	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCCTGTACGACGAGAGCTGCT	0.597000													20	129					0	0	0.018920	0	0
PI4KA	5297	broad.mit.edu	37	22	21115635	21115635	+	Missense_Mutation	SNP	C	T	T			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr22:21115635C>T	uc002zsz.3	-	23	2805	c.2574G>A	c.(2572-2574)ATG>ATA	p.M858I		NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	858					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			AGTAGCAGAACATTACCTGGA	0.368000													11	115					0	0	0.010729	0	0
CYTSA	23384	broad.mit.edu	37	22	24717648	24717648	+	Missense_Mutation	SNP	C	T	T			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr22:24717648C>T	uc002zzw.2	+	5	1007	c.700C>T	c.(700-702)CAC>TAC	p.H234Y	CYTSA_uc002zzv.3_Missense_Mutation_p.H234Y|CYTSA_uc011ajq.1_Missense_Mutation_p.H234Y	NM_015330	NP_056145	Q69YQ0	CYTSA_HUMAN	cytospin A	234	Potential.				cell cycle|cell division						0						TATTATGGCTCACCAGCCGAC	0.438000													80	169					0	0	0.014410	0	0
PLXNB1	5364	broad.mit.edu	37	3	48461210	48461210	+	Missense_Mutation	SNP	G	C	C			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr3:48461210G>C	uc003csw.2	-	11	2755	c.2485C>G	c.(2485-2487)CCA>GCA	p.P829A	PLXNB1_uc003csu.2_Intron|PLXNB1_uc003csx.2_Missense_Mutation_p.P829A|PLXNB1_uc010hjx.1_Intron	NM_002673	NP_002664	O43157	PLXB1_HUMAN	plexin B1 precursor	829	Extracellular (Potential).|Pro-rich.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ATGGCCCCTGGGAAAGTGGTG	0.701000													6	12					0	0	0.029380	0	0
NIPBL	25836	broad.mit.edu	37	5	37008732	37008732	+	Nonsense_Mutation	SNP	C	G	G			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr5:37008732C>G	uc003jkl.3	+	20	4827	c.4328C>G	c.(4327-4329)TCA>TGA	p.S1443*	NIPBL_uc003jkk.3_Nonsense_Mutation_p.S1443*	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	1443					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CAGGTATTCTCAAGATATGAA	0.274000													11	211					0	0	0.013537	0	0
C5orf34	375444	broad.mit.edu	37	5	43506030	43506030	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr5:43506030C>T	uc003jnz.1	-	5	1069	c.752G>A	c.(751-753)TGG>TAG	p.W251*	C5orf34_uc011cpx.1_Nonsense_Mutation_p.W137*	NM_198566	NP_940968	Q96MH7	CE034_HUMAN	hypothetical protein LOC375444	251										breast(1)	1	Lung NSC(6;2.07e-05)					AGGATATTTCCATTCCTCTGG	0.408000													22	243					0	0	0.012319	0	0
SHROOM1	134549	broad.mit.edu	37	5	132158586	132158586	+	Missense_Mutation	SNP	T	C	C			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr5:132158586T>C	uc003kxx.2	-	10	3266	c.2461A>G	c.(2461-2463)AGG>GGG	p.R821G	SHROOM1_uc003kxy.1_Missense_Mutation_p.R816G	NM_133456	NP_597713	Q2M3G4	SHRM1_HUMAN	shroom family member 1	821	ASD2.				actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			pancreas(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGGTCGTCCCTGATGGCGTCC	0.672000													3	48					0	0	0.004672	0	0
ADRB2	154	broad.mit.edu	37	5	148206922	148206922	+	Silent	SNP	C	T	T			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr5:148206922C>T	uc003lpr.1	+	1	767	c.528C>T	c.(526-528)GCC>GCT	p.A176A	SH3TC2_uc003lpp.1_Intron	NM_000024	NP_000015	P07550	ADRB2_HUMAN	adrenergic, beta-2-, receptor, surface	176	Extracellular.				activation of transmembrane receptor protein tyrosine kinase activity|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|endosome to lysosome transport|positive regulation of MAPKKK cascade|receptor-mediated endocytosis	endosome|integral to plasma membrane|lysosome|receptor complex	beta2-adrenergic receptor activity|norepinephrine binding|potassium channel regulator activity|protein homodimerization activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Alprenolol(DB00866)|Arformoterol(DB01274)|Bambuterol(DB01408)|Bisoprolol(DB00612)|Bitolterol(DB00901)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Clenbuterol(DB01407)|Desipramine(DB01151)|Epinephrine(DB00668)|Fenoterol(DB01288)|Formoterol(DB00983)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Nadolol(DB01203)|Norepinephrine(DB00368)|Orciprenaline(DB00816)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Pirbuterol(DB01291)|Procaterol(DB01366)|Propranolol(DB00571)|Pseudoephedrine(DB00852)|Ritodrine(DB00867)|Salbutamol(DB01001)|Salmeterol(DB00938)|Terbutaline(DB00871)|Timolol(DB00373)	GGTACCGGGCCACCCACCAGG	0.537000													20	275					0	0	0.008871	0	0
BAT4	7918	broad.mit.edu	37	6	31630382	31630382	+	Silent	SNP	A	C	C			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr6:31630382A>C	uc003nvn.2	-	3	1377	c.732T>G	c.(730-732)CCT>CCG	p.P244P	C6orf47_uc003nvm.1_5'Flank|BAT4_uc003nvo.3_Silent_p.P244P|BAT4_uc003nvp.3_Silent_p.P244P|BAT4_uc003nvq.2_Silent_p.P244P	NM_033177	NP_149417	O95872	GPAN1_HUMAN	HLA-B associated transcript 4	244						intracellular	nucleic acid binding				0						TGGGAGGCTGAGGACCCTGCG	0.632000													4	115					0	0	0.014758	0	0
GRM1	2911	broad.mit.edu	37	6	146720659	146720659	+	Silent	SNP	G	C	C			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr6:146720659G>C	uc010khw.1	+	8	2954	c.2484G>C	c.(2482-2484)GGG>GGC	p.G828G	GRM1_uc010khv.1_Silent_p.G828G|GRM1_uc003qll.2_Silent_p.G828G|GRM1_uc011edz.1_Silent_p.G828G|GRM1_uc011eea.1_Silent_p.G828G	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	828	Helical; Name=7; (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TGGCTCTGGGGTGCATGTTCA	0.488000													9	116					0	0	0.006214	0	0
OSBPL3	26031	broad.mit.edu	37	7	24903215	24903215	+	Missense_Mutation	SNP	A	G	G			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr7:24903215A>G	uc003sxf.2	-	8	1082	c.677T>C	c.(676-678)CTG>CCG	p.L226P	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Missense_Mutation_p.L226P|OSBPL3_uc003sxh.2_Missense_Mutation_p.L226P|OSBPL3_uc003sxi.2_Missense_Mutation_p.L226P|OSBPL3_uc003sxj.1_5'UTR|OSBPL3_uc003sxk.1_5'UTR	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	226					lipid transport		lipid binding|protein binding			skin(1)	1						ACAGTGCGCCAGGTCTGTGGG	0.532000													7	116					0	0	0.029380	0	0
RALYL	138046	broad.mit.edu	37	8	85774590	85774590	+	Missense_Mutation	SNP	G	A	A			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr8:85774590G>A	uc003ycq.3	+	7	889	c.473G>A	c.(472-474)CGT>CAT	p.R158H	RALYL_uc003ycr.3_Missense_Mutation_p.R158H|RALYL_uc003ycs.3_Missense_Mutation_p.R158H|RALYL_uc010lzy.2_Missense_Mutation_p.R147H|RALYL_uc003yct.3_Missense_Mutation_p.R171H|RALYL_uc003ycu.3_Missense_Mutation_p.R85H|RALYL_uc003ycv.3_Missense_Mutation_p.R70H	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	158							identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						CCGCTGAAGCGTCCCAGAGTG	0.507000													6	43					0	0	0.029380	0	0
KLF4	9314	broad.mit.edu	37	9	110249405	110249405	+	Missense_Mutation	SNP	G	A	A			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr9:110249405G>A	uc004bdh.2	-	3	1864	c.1243C>T	c.(1243-1245)CGG>TGG	p.R415W	KLF4_uc004bdf.1_Missense_Mutation_p.R340W|KLF4_uc004bdg.2_Missense_Mutation_p.R390W	NM_004235	NP_004226	O43474	KLF4_HUMAN	Kruppel-like factor 4 (gut)	424					fat cell differentiation|mesodermal cell fate determination|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|stem cell maintenance|transcription from RNA polymerase II promoter	nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(2)|lung(1)	3						GTCCTTTTCCGGGGCCACGAT	0.587000													88	161					0	0	0.014410	0	0
NRL	4901	broad.mit.edu	37	14	24551825	24551826	+	Frame_Shift_Ins	INS	-	G	G			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr14:24551825_24551826insG	uc001wlo.2	-	2	363_364	c.232_233insC	c.(232-234)CTGfs	p.L78fs	NRL_uc001wlp.2_Frame_Shift_Ins_p.L78fs|NRL_uc001wlq.2_Frame_Shift_Ins_p.L78fs	NM_006177	NP_006168	P54845	NRL_HUMAN	neural retina leucine zipper	78					response to stimulus|transcription from RNA polymerase II promoter|visual perception	nucleus	leucine zipper domain binding|sequence-specific DNA binding				0				GBM - Glioblastoma multiforme(265;0.0181)		CTGCTGCTGCAGGGTAGCCAGC	0.663													7	53	---	---	---	---					
CIC	23152	broad.mit.edu	37	19	42797299	42797300	+	Frame_Shift_Del	DEL	TC	-	-			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr19:42797299_42797300delTC	uc002otf.1	+	15	3701_3702	c.3661_3662delTC	c.(3661-3663)TCTfs	p.S1221fs		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	1221	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				TGCCCCAGAGTCTGAGCTTGAG	0.718			T	DUX4	soft tissue sarcoma								9	7	---	---	---	---					
SLC9A9	285195	broad.mit.edu	37	3	143100927	143100932	+	In_Frame_Del	DEL	TTCAGA	-	-			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr3:143100927_143100932delTTCAGA	uc003evn.2	-	13	1676_1681	c.1494_1499delTCTGAA	c.(1492-1500)AATCTGAAG>AAG	p.NL498del		NM_173653	NP_775924	Q8IVB4	SL9A9_HUMAN	solute carrier family 9 (sodium/hydrogen	498_499					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3						GGGGTCCTCCTTCAGATTTTCATCCA	0.442													8	538	---	---	---	---					
DPYS	1807	broad.mit.edu	37	8	105440214	105440214	+	Frame_Shift_Del	DEL	T	-	-			TCGA-DH-5141-01A-01D-1468-08	TCGA-DH-5141-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	b77c396b-3f9c-4f1a-864e-f92793906b9d	8ab5bff0-41b4-493c-9626-d706d1c6aa38	g.chr8:105440214delT	uc003yly.3	-	6	1215	c.1086delA	c.(1084-1086)AAAfs	p.K362fs		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	362					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CCACCACGCCTTTTTCCCATA	0.478													7	513	---	---	---	---					
