Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PRAMEF11	440560	broad.mit.edu	37	1	12885289	12885289	+	Silent	SNP	G	T	T	rs148273194	by1000genomes	TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr1:12885289G>T	uc001auk.2	-	4	1018	c.822C>A	c.(820-822)CTC>CTA	p.L274L		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	274	LRR 3.										0						GGCACTGGGAGAGATGCTTCA	0.458000													6	404					3.07112e-06	3.65424e-06	0.000978	1	0
C1orf168	199920	broad.mit.edu	37	1	57258301	57258301	+	Missense_Mutation	SNP	C	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr1:57258301C>T	uc001cym.3	-	2	591	c.185G>A	c.(184-186)CGC>CAC	p.R62H	C1orf168_uc009vzu.1_RNA|C1orf168_uc009vzv.1_Missense_Mutation_p.R62H	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	62										ovary(3)|skin(2)	5						GTATGGTGTGCGCTGCTTGTG	0.473000													15	322					0	0	0.003163	0	0
KANK4	163782	broad.mit.edu	37	1	62739569	62739569	+	Missense_Mutation	SNP	C	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr1:62739569C>T	uc001dah.3	-	3	1584	c.1207G>A	c.(1207-1209)GCC>ACC	p.A403T	KANK4_uc001dai.3_Intron|KANK4_uc001dag.3_5'Flank	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	403	Potential.									ovary(3)|skin(2)|lung(1)	6						GTGTCTTTGGCGTTCTCTTGG	0.517000													5	325					0	0	0.001168	0	0
AMY2B	280	broad.mit.edu	37	1	104115689	104115689	+	Missense_Mutation	SNP	G	A	A			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr1:104115689G>A	uc001duq.2	+	5	936	c.320G>A	c.(319-321)CGT>CAT	p.R107H	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.R107H|AMY2B_uc001dus.1_5'Flank	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	107					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		TTCTAGGTTCGTATTTATGTG	0.368000													144	782					0	0	0.003610	0	0
MUC1	4582	broad.mit.edu	37	1	155160204	155160204	+	Missense_Mutation	SNP	C	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr1:155160204C>T	uc010pfj.1	-	4	1106	c.700G>A	c.(700-702)GTC>ATC	p.V234I	RAG1AP1_uc010pey.1_Intron|MUC1_uc001fhy.2_Missense_Mutation_p.V64I|MUC1_uc001fhz.2_Missense_Mutation_p.V64I|MUC1_uc010pfb.1_Missense_Mutation_p.V64I|MUC1_uc010pfc.1_RNA|MUC1_uc009wph.2_Missense_Mutation_p.V64I|MUC1_uc010pfd.1_Intron|MUC1_uc010pfe.1_RNA|MUC1_uc010pff.1_Intron|MUC1_uc009wpi.2_Missense_Mutation_p.V64I|MUC1_uc010pfg.1_Intron|MUC1_uc010pfh.1_Missense_Mutation_p.V210I|MUC1_uc010pfi.1_Missense_Mutation_p.V210I|MUC1_uc010pfk.1_RNA|MUC1_uc010pfl.1_RNA|MUC1_uc001fin.2_Intron|MUC1_uc009wpk.2_Missense_Mutation_p.V86I|MUC1_uc001fip.2_Intron|MUC1_uc009wqg.2_Missense_Mutation_p.V95I|MUC1_uc009wpo.2_Missense_Mutation_p.V101I|MUC1_uc009wps.2_Missense_Mutation_p.V122I|MUC1_uc009wpt.2_Missense_Mutation_p.V125I|MUC1_uc001fic.2_Missense_Mutation_p.V113I|MUC1_uc009wpu.2_Intron|MUC1_uc009wpq.2_Missense_Mutation_p.V127I|MUC1_uc009wpv.2_Intron|MUC1_uc001fim.2_Intron|MUC1_uc001fib.2_Intron|MUC1_uc009wpw.2_Intron|MUC1_uc001fie.2_Intron|MUC1_uc009wpr.2_Intron|MUC1_uc001fig.2_Intron|MUC1_uc001fif.2_Intron|MUC1_uc009wpx.2_Missense_Mutation_p.V123I|MUC1_uc001fid.2_Missense_Mutation_p.V114I|MUC1_uc009wpj.2_Intron|MUC1_uc001fij.2_Missense_Mutation_p.V148I|MUC1_uc009wpy.2_Intron|MUC1_uc010pfm.1_Missense_Mutation_p.V64I|MUC1_uc001fiq.2_Missense_Mutation_p.V64I|MUC1_uc009wpz.2_Missense_Mutation_p.V166I|MUC1_uc010pfn.1_Missense_Mutation_p.V139I|MUC1_uc009wqa.2_Missense_Mutation_p.V222I|MUC1_uc010pfo.1_Intron|MUC1_uc010pfp.1_Intron|MUC1_uc001fii.2_Intron|MUC1_uc001fih.2_Intron|MUC1_uc001fia.2_Missense_Mutation_p.V139I|MUC1_uc009wqc.2_Missense_Mutation_p.V136I|MUC1_uc009wqd.2_Missense_Mutation_p.V160I|MUC1_uc009wqb.2_Missense_Mutation_p.V64I|MUC1_uc010pfq.1_Missense_Mutation_p.V136I|MUC1_uc010pfr.1_Intron|MUC1_uc001fit.2_Missense_Mutation_p.V64I|MUC1_uc009wqe.2_Intron|MUC1_uc001fil.2_Intron|MUC1_uc009wpm.2_Missense_Mutation_p.V157I|MUC1_uc009wpp.2_Intron|MUC1_uc010pfs.1_RNA|MUC1_uc001fik.2_Missense_Mutation_p.V157I|MUC1_uc001fio.2_Intron|MUC1_uc009wqf.2_Intron|MUC1_uc009wpl.2_Intron|MUC1_uc009wpn.2_Missense_Mutation_p.V148I|MUC1_uc001fis.1_Intron			P15941	MUC1_HUMAN	SubName: Full=Mucin 1, cell surface associated;	1139	Extracellular (Potential).|SEA.					apical plasma membrane|cell surface|cytoplasm|extracellular region|integral to plasma membrane|nucleus	protein binding			large_intestine(1)|pancreas(1)|breast(1)|skin(1)	4	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;5.31e-10)|all cancers(21;2.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TCACCGCTGACGTCTGAGATC	0.577000			T	IGH@	B-NHL								6	58					0	0	0.003080	0	0
AIM2	9447	broad.mit.edu	37	1	159035847	159035847	+	Silent	SNP	G	A	A	rs148686373		TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr1:159035847G>A	uc001ftj.1	-	4	914	c.669C>T	c.(667-669)AGC>AGT	p.S223S		NM_004833	NP_004824	O14862	AIM2_HUMAN	absent in melanoma 2	223	HIN-200.				cellular response to drug|immune response|interleukin-1 beta secretion	mitochondrion|nucleus				ovary(2)|pancreas(1)	3	all_hematologic(112;0.0429)					CACGTGAGGCGCTATTTACCT	0.368000													32	311					0	0	0.002096	0	0
KIAA1614	57710	broad.mit.edu	37	1	180904728	180904728	+	Silent	SNP	G	A	A			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr1:180904728G>A	uc001gok.2	+	5	1750	c.1683G>A	c.(1681-1683)CAG>CAA	p.Q561Q	KIAA1614_uc001gol.1_Silent_p.Q182Q|KIAA1614_uc001gom.1_Intron	NM_020950	NP_066001	Q5VZ46	K1614_HUMAN	hypothetical protein LOC57710	561										ovary(3)|skin(1)	4						GGACCCTCCAGGAGCTCCAGG	0.726000													3	32					0	0	0.004672	0	0
RNASEL	6041	broad.mit.edu	37	1	182554707	182554707	+	Missense_Mutation	SNP	C	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr1:182554707C>T	uc001gpj.1	-	1	1402	c.1235G>A	c.(1234-1236)CGA>CAA	p.R412Q	RNASEL_uc009wxz.1_Missense_Mutation_p.R412Q|RNASEL_uc001gpk.2_Missense_Mutation_p.R412Q|RNASEL_uc009wya.1_Missense_Mutation_p.R412Q	NM_021133	NP_066956	Q05823	RN5A_HUMAN	ribonuclease L	412	Protein kinase.|C6-type; atypical.				mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			ovary(4)|stomach(1)	5						ACTGTTCTCTCGGCTGCTTTG	0.532000									Hereditary_Prostate_Cancer				14	175					0	0	0.004007	0	0
FMOD	2331	broad.mit.edu	37	1	203316988	203316988	+	Silent	SNP	G	A	A	rs141206727		TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr1:203316988G>A	uc001gzr.2	-	2	547	c.411C>T	c.(409-411)CAC>CAT	p.H137H	FMOD_uc010pqi.1_RNA	NM_002023	NP_002014	Q06828	FMOD_HUMAN	fibromodulin precursor	137	LRR 2.				transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				ovary(2)|breast(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.171)			TCTGGTTGCCGTGGAGAGCAA	0.557000													5	170					0	0	0.001168	0	0
EPRS	2058	broad.mit.edu	37	1	220195728	220195728	+	Missense_Mutation	SNP	C	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr1:220195728C>T	uc001hly.1	-	9	1346	c.1076G>A	c.(1075-1077)TGC>TAC	p.C359Y	EPRS_uc010puf.1_Missense_Mutation_p.C110Y|EPRS_uc001hlz.1_Missense_Mutation_p.C359Y|EPRS_uc009xdt.1_Missense_Mutation_p.C160Y	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	359	Glutamyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	TTGAATTTTGCAGCGATAAAG	0.378000													7	406					0	0	0.001984	0	0
HEATR1	55127	broad.mit.edu	37	1	236724539	236724539	+	Silent	SNP	T	C	C			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr1:236724539T>C	uc001hyd.1	-	33	4757	c.4632A>G	c.(4630-4632)AAA>AAG	p.K1544K	HEATR1_uc009xgh.1_Silent_p.K706K	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	1544					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			CTTCAAGGCCTTTTAAAATCT	0.244000													3	210					0	0	0.000248	0	0
CUBN	8029	broad.mit.edu	37	10	16883005	16883005	+	Silent	SNP	C	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr10:16883005C>T	uc001ioo.2	-	61	9757	c.9705G>A	c.(9703-9705)ACG>ACA	p.T3235T		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3235	CUB 24.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AACCACAAAACGTTCCAGCCA	0.363000													16	99					0	0	0.004007	0	0
MYO3A	53904	broad.mit.edu	37	10	26243813	26243813	+	Missense_Mutation	SNP	A	G	G			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr10:26243813A>G	uc001isn.2	+	4	539	c.179A>G	c.(178-180)GAA>GGA	p.E60G	MYO3A_uc009xko.1_Missense_Mutation_p.E60G|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.E60G|MYO3A_uc001ism.2_Missense_Mutation_p.E60G	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	60	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						GATATTGACGAAGAGATTGAA	0.318000													18	260					0	0	0.008871	0	0
PSD	5662	broad.mit.edu	37	10	104173754	104173754	+	Missense_Mutation	SNP	A	C	C			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr10:104173754A>C	uc001kvg.1	-	5	1852	c.1325T>G	c.(1324-1326)TTT>TGT	p.F442C	PSD_uc001kvh.1_Missense_Mutation_p.F63C|PSD_uc009xxd.1_Missense_Mutation_p.F442C	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	442	Pro-rich.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		AGGCAGCTCAAAGGTGAAGAA	0.652000													10	109					0	0	0.008291	0	0
SBF2	81846	broad.mit.edu	37	11	9864268	9864268	+	Missense_Mutation	SNP	T	C	C			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr11:9864268T>C	uc001mib.2	-	25	3298	c.3160A>G	c.(3160-3162)ACA>GCA	p.T1054A	SBF2_uc001mif.3_Missense_Mutation_p.T810A|uc001mig.2_Intron	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	1054					myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		CGCCCAATTGTCATTTTCCCT	0.373000													4	111					0	0	0.000602	0	0
GAS2	2620	broad.mit.edu	37	11	22747932	22747932	+	Missense_Mutation	SNP	G	A	A			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr11:22747932G>A	uc009yie.2	+	4	668	c.362G>A	c.(361-363)CGA>CAA	p.R121Q	GAS2_uc001mqm.2_Missense_Mutation_p.R121Q|GAS2_uc001mqn.2_RNA|GAS2_uc001mqo.2_Missense_Mutation_p.R121Q	NM_001143830	NP_001137302	O43903	GAS2_HUMAN	growth arrest-specific 2	121	CH.				cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				ovary(1)|skin(1)	2						TCCTGGTGCCGAGATTTAGGG	0.398000													15	138					0	0	0.002450	0	0
OR1S1	219959	broad.mit.edu	37	11	57982589	57982589	+	Missense_Mutation	SNP	A	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr11:57982589A>T	uc010rkc.1	+	1	373	c.373A>T	c.(373-375)AAT>TAT	p.N125Y		NM_001004458	NP_001004458	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S,	125	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Breast(21;0.0589)				CGTCATTGACAATTTGCTCTT	0.453000													171	246					0	0	0.003610	0	0
C11orf75	56935	broad.mit.edu	37	11	93212240	93212240	+	Missense_Mutation	SNP	G	A	A			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr11:93212240G>A	uc001pds.3	-	3	374	c.116C>T	c.(115-117)GCC>GTC	p.A39V	C11orf75_uc001pdr.2_RNA	NM_020179	NP_064564	Q9NRQ5	CK075_HUMAN	hypothetical protein LOC56935	39	Helical; (Potential).					integral to membrane					0		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				CACGACCACGGCCAGCGTGGG	0.652000													10	92					0	0	0.008291	0	0
OAF	220323	broad.mit.edu	37	11	120097624	120097624	+	Missense_Mutation	SNP	C	G	G			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr11:120097624C>G	uc001pxb.2	+	3	707	c.466C>G	c.(466-468)CCC>GCC	p.P156A		NM_178507	NP_848602	Q86UD1	OAF_HUMAN	OAF homolog precursor	156											0		Breast(109;0.00663)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)		CCTGCTGAGCCCCCATCTCCA	0.642000													54	75					0	0	0.003610	0	0
CDKN1B	1027	broad.mit.edu	37	12	12871757	12871757	+	Splice_Site	SNP	A	C	C			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr12:12871757A>C	uc001rat.2	+	2	948	c.476_splice	c.e2-2	p.D159_splice		NM_004064	NP_004055	P46527	CDN1B_HUMAN	cyclin-dependent kinase inhibitor 1B						autophagic cell death|cell cycle arrest|cellular response to lithium ion|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process|S phase of mitotic cell cycle	cytosol|endosome|nucleoplasm	cyclin-dependent protein kinase inhibitor activity|protein phosphatase binding|transforming growth factor beta receptor, cytoplasmic mediator activity			ovary(1)|lung(1)	2		Prostate(47;0.0322)|all_epithelial(100;0.159)		BRCA - Breast invasive adenocarcinoma(232;0.0336)		CCCTGCGCTTAGATTCTTCTA	0.433000									Multiple_Endocrine_Neoplasia_type_1|Multiple_Endocrine_Neoplasia_type_4				6	295					0	0	0.001984	0	0
LST-3TM12	338821	broad.mit.edu	37	12	21205042	21205042	+	Silent	SNP	A	C	C			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr12:21205042A>C	uc010sin.1	+	9	1203	c.1203A>C	c.(1201-1203)GTA>GTC	p.V401V	SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Silent_p.V448V	NM_001009562	NP_001009562	Q71QF0	Q71QF0_HUMAN	liver-specific organic anion transporter 3TM12	401						membrane	transporter activity				0						ATAGTCCAGTAAGATCTCATG	0.249000													24	123					0	0	0.002780	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43925953	43925953	+	Missense_Mutation	SNP	T	C	C			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr12:43925953T>C	uc010skx.1	-	3	499	c.499A>G	c.(499-501)ATA>GTA	p.I167V		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	167						proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GCCTTCATTATAGGTTCTAAG	0.343000													12	147					0	0	0.001368	0	0
PTPRR	5801	broad.mit.edu	37	12	71286466	71286466	+	Missense_Mutation	SNP	A	G	G			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr12:71286466A>G	uc001swi.1	-	2	766	c.350T>C	c.(349-351)ATT>ACT	p.I117T		NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	117	Extracellular (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		TACCACCACAATTACATTTGC	0.413000													4	246					0	0	0.000248	0	0
C12orf65	91574	broad.mit.edu	37	12	123741402	123741402	+	Missense_Mutation	SNP	C	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr12:123741402C>T	uc001uen.2	+	3	591	c.325C>T	c.(325-327)CGG>TGG	p.R109W	C12orf65_uc001ueo.2_RNA|C12orf65_uc010tan.1_Missense_Mutation_p.R109W	NM_152269	NP_689482	Q9H3J6	CL065_HUMAN	hypothetical protein LOC91574	109						mitochondrion	translation release factor activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000595)|Epithelial(86;0.00199)		AAAGCTAGCTCGGAAAATCCT	0.234000													6	100					0	0	0.001168	0	0
TP53	7157	broad.mit.edu	37	17	7578271	7578271	+	Missense_Mutation	SNP	T	C	C			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr17:7578271T>C	uc002gim.2	-	6	772	c.578A>G	c.(577-579)CAT>CGT	p.H193R	TP53_uc002gig.1_Missense_Mutation_p.H193R|TP53_uc002gih.2_Missense_Mutation_p.H193R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H61R|TP53_uc010cng.1_Missense_Mutation_p.H61R|TP53_uc002gii.1_Missense_Mutation_p.H61R|TP53_uc010cnh.1_Missense_Mutation_p.H193R|TP53_uc010cni.1_Missense_Mutation_p.H193R|TP53_uc002gij.2_Missense_Mutation_p.H193R|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.H100R|TP53_uc002gio.2_Missense_Mutation_p.H61R|TP53_uc010vug.1_Missense_Mutation_p.H154R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	193	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		H -> D (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> R (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H193R(67)|p.H193L(31)|p.H193Y(26)|p.H193P(12)|p.0?(7)|p.H193D(7)|p.H193N(4)|p.A189_V197delAPPQHLIRV(4)|p.H193fs*16(3)|p.H193H(2)|p.P191fs*53(2)|p.K164_P219del(1)|p.P191fs*15(1)|p.P191fs*6(1)|p.H100L(1)|p.H61L(1)|p.H193_I195delHLI(1)|p.H193_I195>AP(1)|p.A189fs*53(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCGGATAAGATGCTGAGGAGG	0.562000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			74	12					0	0	0.003610	0	0
MYH8	4626	broad.mit.edu	37	17	10309482	10309482	+	Missense_Mutation	SNP	C	G	G			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr17:10309482C>G	uc002gmm.2	-	21	2403	c.2308G>C	c.(2308-2310)GCT>CCT	p.A770P	uc002gml.1_RNA	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	770	Actin-binding.|Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						AGAAGTCCAGCTTTGAAGAAA	0.403000									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				48	77					0	0	0.003610	0	0
UNC45B	146862	broad.mit.edu	37	17	33482401	33482401	+	Silent	SNP	C	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr17:33482401C>T	uc002hja.2	+	7	823	c.726C>T	c.(724-726)TGC>TGT	p.C242C	UNC45B_uc002hjb.2_Silent_p.C242C|UNC45B_uc002hjc.2_Silent_p.C242C|UNC45B_uc010cto.2_Silent_p.C242C	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	242	ARM 2.				cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				TGGCTGTCTGCAACCTGCTCC	0.552000													23	200					0	0	0.002780	0	0
GAS2L2	246176	broad.mit.edu	37	17	34072135	34072135	+	Missense_Mutation	SNP	C	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr17:34072135C>T	uc002hjv.1	-	6	2409	c.2381G>A	c.(2380-2382)CGA>CAA	p.R794Q		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	794					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCTGGGGATTCGTGAAGGCTG	0.632000													16	261					0	0	0.006122	0	0
Unknown	0	broad.mit.edu	37	17	76497744	76497744	+	RNA	SNP	T	G	G			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr17:76497744T>G	uc002jvt.1	+	2		c.3203T>G								Homo sapiens cDNA FLJ45552 fis, clone BRTHA2038279.																		AGTGGCAGGGTCTGAAGTCCC	0.627000													10	24					0	0	0.002852	0	0
ZNF99	7652	broad.mit.edu	37	19	22941101	22941101	+	Missense_Mutation	SNP	T	C	C			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr19:22941101T>C	uc010xrh.1	-	5	1337	c.1337A>G	c.(1336-1338)TAC>TGC	p.Y446C		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTCACATTTGTAGGGTTTCTT	0.343000													5	275					0	0	0.001984	0	0
KCNC3	3748	broad.mit.edu	37	19	50826645	50826645	+	Missense_Mutation	SNP	A	G	G			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr19:50826645A>G	uc002pru.1	-	2	1860	c.1565T>C	c.(1564-1566)CTG>CCG	p.L522P	KCNC3_uc002prt.1_Missense_Mutation_p.L158P	NM_004977	NP_004968	Q14003	KCNC3_HUMAN	Shaw-related voltage-gated potassium channel	522	Helical; Name=Segment S6; (Potential).				cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		CAGGGCACACAGCGCCCCGAC	0.602000													3	74					0	0	0.004672	0	0
ZNF845	91664	broad.mit.edu	37	19	53856702	53856702	+	Missense_Mutation	SNP	G	A	A	rs150688663	by1000genomes	TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr19:53856702G>A	uc010ydv.1	+	4	2891	c.2774G>A	c.(2773-2775)CGT>CAT	p.R925H	ZNF845_uc010ydw.1_Missense_Mutation_p.R925H	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	925	C2H2-type 26.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAAACCTTCCGTCACAATTCA	0.363000													3	40					0	0	0.004672	0	0
ZNF845	91664	broad.mit.edu	37	19	53856730	53856730	+	Silent	SNP	G	A	A			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr19:53856730G>A	uc010ydv.1	+	4	2919	c.2802G>A	c.(2800-2802)AAG>AAA	p.K934K	ZNF845_uc010ydw.1_Silent_p.K934K	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	934	C2H2-type 26.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAATTCATAAGACAATTCATA	0.368000													3	43					0	0	0.004672	0	0
NTSR2	23620	broad.mit.edu	37	2	11798782	11798782	+	Silent	SNP	A	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr2:11798782A>T	uc002rbq.3	-	4	1130	c.1056T>A	c.(1054-1056)GCT>GCA	p.A352A		NM_012344	NP_036476	O95665	NTR2_HUMAN	neurotensin receptor 2	352	Helical; Name=7; (Potential).				sensory perception	integral to plasma membrane					0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	GAGGAGTCACAGCTGAGCTGA	0.532000													4	174					0	0	0.000602	0	0
SNX17	9784	broad.mit.edu	37	2	27599364	27599364	+	Missense_Mutation	SNP	C	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr2:27599364C>T	uc002rkg.1	+	14	1498	c.1276C>T	c.(1276-1278)CGG>TGG	p.R426W	SNX17_uc010ylj.1_Missense_Mutation_p.R406W|SNX17_uc010ylk.1_Missense_Mutation_p.R212W|SNX17_uc010eza.1_Missense_Mutation_p.R212W|SNX17_uc002rki.1_RNA|SNX17_uc002rkh.1_Missense_Mutation_p.R212W|SNX17_uc010yll.1_Missense_Mutation_p.R212W|SNX17_uc010ylm.1_Missense_Mutation_p.R212W|SNX17_uc010yln.1_Missense_Mutation_p.R414W|SNX17_uc010ylo.1_Missense_Mutation_p.R344W|SNX17_uc010ylp.1_Missense_Mutation_p.R401W|SNX17_uc010ylq.1_Missense_Mutation_p.R212W	NM_014748	NP_055563	Q15036	SNX17_HUMAN	sorting nexin 17	426					cell communication|endosome transport|intracellular protein transport|regulation of endocytosis|signal transduction	cytoplasmic vesicle membrane|cytosol|early endosome|Golgi apparatus	low-density lipoprotein particle receptor binding|phosphatidylinositol binding|protein C-terminus binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGATGCCACCCGGGAGTCTAT	0.572000													77	258					0	0	0.003610	0	0
MGAT4A	11320	broad.mit.edu	37	2	99279632	99279632	+	Silent	SNP	G	A	A			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr2:99279632G>A	uc002sze.2	-	5	728	c.414C>T	c.(412-414)GTC>GTT	p.V138V	MGAT4A_uc010yvm.1_Silent_p.V10V|MGAT4A_uc010fil.2_5'UTR|MGAT4A_uc010fim.1_Silent_p.V10V	NM_012214	NP_036346	Q9UM21	MGT4A_HUMAN	alpha-1,3-mannosyl-glycoprotein	138	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1						GAATGCCCATGACTATTGAAA	0.318000													6	469					0	0	0.001168	0	0
PTPN18	26469	broad.mit.edu	37	2	131116491	131116491	+	Missense_Mutation	SNP	G	A	A	rs11892325	byFrequency	TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr2:131116491G>A	uc002trc.2	+	2	246	c.145G>A	c.(145-147)GTG>ATG	p.V49M	PTPN18_uc002trd.2_Missense_Mutation_p.V49M|PTPN18_uc002trb.2_Intron	NM_014369	NP_055184	Q99952	PTN18_HUMAN	protein tyrosine phosphatase, non-receptor type	49	Tyrosine-protein phosphatase.					cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity			ovary(3)|kidney(1)	4	Colorectal(110;0.1)					GTGCTCCACCGTGGCCGGCAG	0.627000													56	136					0	0	0.003610	0	0
LRP1B	53353	broad.mit.edu	37	2	141528521	141528521	+	Missense_Mutation	SNP	G	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr2:141528521G>T	uc002tvj.1	-	34	6527	c.5555C>A	c.(5554-5556)ACA>AAA	p.T1852K		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1852	Extracellular (Potential).|EGF-like 4.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGTTTCAGATGTTGGTAAACA	0.353000										TSP Lung(27;0.18)			13	215					0.00010058	0.000118181	0.001368	1	0
NEB	4703	broad.mit.edu	37	2	152342397	152342397	+	Silent	SNP	C	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr2:152342397C>T	uc010fnx.2	-	149	20078	c.19887G>A	c.(19885-19887)GTG>GTA	p.V6629V	NEB_uc002txr.2_Silent_p.V2959V|RIF1_uc002txp.2_Intron|NEB_uc010zbz.1_Silent_p.V398V|NEB_uc002txq.2_Silent_p.V508V|NEB_uc010zca.1_Silent_p.V460V|NEB_uc010zcb.1_Silent_p.V398V	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	6629	SH3.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CCTTGAAGGACACCTCATCTG	0.458000													67	130					0	0	0.003610	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								41	66					0	0	0.006230	0	0
C2orf62	375307	broad.mit.edu	37	2	219232561	219232561	+	Silent	SNP	C	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr2:219232561C>T	uc002vhr.2	+	10	1067	c.1038C>T	c.(1036-1038)TTC>TTT	p.F346F	C2orf62_uc002vhs.2_RNA|uc002vht.2_5'Flank	NM_198559	NP_940961	Q7Z7H3	CB062_HUMAN	hypothetical protein LOC375307	346											0		Renal(207;0.0915)		Epithelial(149;8.08e-07)|all cancers(144;0.000146)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGTCACCTTCGCCGCCGAGT	0.701000													6	53					0	0	0.001168	0	0
SIRPD	128646	broad.mit.edu	37	20	1517834	1517834	+	Missense_Mutation	SNP	G	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr20:1517834G>T	uc002wfi.2	-	3	588	c.544C>A	c.(544-546)CCC>ACC	p.P182T		NM_178460	NP_848555	Q9H106	SIRPD_HUMAN	signal-regulatory protein delta precursor	182						extracellular region				ovary(1)|kidney(1)|skin(1)	3						CAGCAGCAGGGTTGGACGAAA	0.607000													43	139					3.77016e-25	4.66309e-25	0.003214	1	0
DNMT3B	1789	broad.mit.edu	37	20	31372610	31372610	+	Missense_Mutation	SNP	C	G	G	rs138276579		TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr20:31372610C>G	uc002wyc.2	+	4	572	c.251C>G	c.(250-252)ACC>AGC	p.T84S	DNMT3B_uc010ztx.1_RNA|DNMT3B_uc010zty.1_RNA|DNMT3B_uc002wyd.2_Missense_Mutation_p.T84S|DNMT3B_uc002wye.2_Missense_Mutation_p.T84S|DNMT3B_uc010gee.2_RNA|DNMT3B_uc010gef.2_RNA|DNMT3B_uc010ztz.1_Missense_Mutation_p.T84S|DNMT3B_uc010zua.1_Intron|DNMT3B_uc002wyf.2_Missense_Mutation_p.T96S	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform	84	Interaction with DNMT1 and DNMT3A.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5						GGCTCTGACACCCCAGTCATG	0.527000													3	143					0	0	0.004672	0	0
RTDR1	27156	broad.mit.edu	37	22	23401832	23401832	+	Missense_Mutation	SNP	C	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr22:23401832C>T	uc002zwt.2	-	7	1013	c.855G>A	c.(853-855)ATG>ATA	p.M285I		NM_014433	NP_055248	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region protein 1	285							binding			ovary(1)	1	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		GCGCTATGGTCATGGGGGAGT	0.657000													59	190					0	0	0.003610	0	0
LOC220729	220729	broad.mit.edu	37	3	197348674	197348674	+	RNA	SNP	A	G	G	rs144273946	by1000genomes	TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr3:197348674A>G	uc011bug.1	-	4		c.417T>C			LOC220729_uc003fxw.2_RNA|LOC220729_uc003fxy.2_RNA|LOC220729_uc010iao.1_Intron					Homo sapiens cDNA FLJ60865 complete cds, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1).												0						GGCTCTGTCCACCAAATGCAC	0.478000													3	197					0	0	0.004672	0	0
CCDC158	339965	broad.mit.edu	37	4	77244544	77244544	+	Missense_Mutation	SNP	A	G	G			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr4:77244544A>G	uc003hkb.3	-	23	3329	c.3176T>C	c.(3175-3177)ATA>ACA	p.I1059T		NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	1059										skin(3)|ovary(2)|pancreas(1)	6						TGTTGTTTCTATTGGCGGAGA	0.353000													35	343					0	0	0.002836	0	0
CCNG2	901	broad.mit.edu	37	4	78081991	78081991	+	Nonsense_Mutation	SNP	A	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr4:78081991A>T	uc003hkq.3	+	4	697	c.394A>T	c.(394-396)AAA>TAA	p.K132*	CCNG2_uc003hkn.3_Nonsense_Mutation_p.K132*|CCNG2_uc011ccc.1_Nonsense_Mutation_p.K132*|CCNG2_uc003hkp.3_Nonsense_Mutation_p.K132*	NM_004354	NP_004345	Q16589	CCNG2_HUMAN	cyclin G2	132					cell cycle checkpoint|cell division|mitosis	cytoplasm				ovary(2)|lung(1)	3						TAGTCAGTGTAAATGTACTGC	0.363000													92	148					0	0	0.003610	0	0
PDHA2	5161	broad.mit.edu	37	4	96761615	96761615	+	Missense_Mutation	SNP	G	A	A			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr4:96761615G>A	uc003htr.3	+	1	377	c.314G>A	c.(313-315)GGC>GAC	p.G105D		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	105					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	CTTGAGGCCGGCATAAACCCC	0.517000													5	228					0	0	0.000602	0	0
TET2	54790	broad.mit.edu	37	4	106156834	106156834	+	Missense_Mutation	SNP	C	G	G			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr4:106156834C>G	uc003hxk.2	+	3	2121	c.1735C>G	c.(1735-1737)CTA>GTA	p.L579V	TET2_uc011cez.1_Missense_Mutation_p.L600V|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Missense_Mutation_p.L579V|TET2_uc003hxi.1_Missense_Mutation_p.L579V	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	579					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		GGAATCCCATCTAAAACGTAA	0.453000			Mis N|F		MDS								5	152					0	0	0.000602	0	0
ALPK1	80216	broad.mit.edu	37	4	113362097	113362097	+	Missense_Mutation	SNP	G	A	A			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr4:113362097G>A	uc003iap.3	+	15	3842	c.3563G>A	c.(3562-3564)GGA>GAA	p.G1188E	ALPK1_uc003ian.3_Missense_Mutation_p.G1188E|ALPK1_uc011cfx.1_Missense_Mutation_p.G1110E|ALPK1_uc003iao.3_RNA|ALPK1_uc010imo.2_Missense_Mutation_p.G1016E	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	1188	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		AATGGAAAAGGACTCATCTAC	0.348000													5	269					0	0	0.000602	0	0
ZDHHC11	79844	broad.mit.edu	37	5	850710	850710	+	Missense_Mutation	SNP	G	A	A			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr5:850710G>A	uc011cma.1	-	1	392	c.8C>T	c.(7-9)ACC>ATC	p.T3I	ZDHHC11_uc003jbj.2_5'Flank	NM_024786	NP_079062	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	3						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)|pancreas(1)	2			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			CCCGGAGCGGGTGTCCATCTG	0.617000													5	142					0	0	0.000602	0	0
MCCC2	64087	broad.mit.edu	37	5	70944989	70944989	+	Missense_Mutation	SNP	G	A	A			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr5:70944989G>A	uc003kbs.3	+	14	1420	c.1282G>A	c.(1282-1284)GCT>ACT	p.A428T	MCCC2_uc003kbt.3_RNA	NM_022132	NP_071415	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	428	Carboxyltransferase.				leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)	1		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	GATGGTGGCCGCTGTGGCCTG	0.512000													5	152					0	0	0.000602	0	0
RHAG	6005	broad.mit.edu	37	6	49604490	49604490	+	Silent	SNP	C	A	A			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr6:49604490C>A	uc003ozk.3	-	1	98	c.36G>T	c.(34-36)CTG>CTT	p.L12L	RHAG_uc010jzl.2_Silent_p.L12L|RHAG_uc010jzm.2_Silent_p.L12L	NM_000324	NP_000315	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	12	Helical; (Potential).				carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|skin(1)	2	Lung NSC(77;0.0255)					TGGCAATTTCCAGGACTATAG	0.443000													61	140					2.5401e-28	3.18359e-28	0.003610	1	0
REV3L	5980	broad.mit.edu	37	6	111726682	111726682	+	Silent	SNP	T	G	G			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr6:111726682T>G	uc003puy.3	-	4	879	c.556A>C	c.(556-558)AGA>CGA	p.R186R	REV3L_uc003pux.3_Silent_p.R108R|REV3L_uc003puz.3_Silent_p.R108R	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	186					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		CTTTTCCTTCTTGCTTTTCGG	0.299000								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					7	203					0	0	0.001984	0	0
BCLAF1	9774	broad.mit.edu	37	6	136597607	136597607	+	Missense_Mutation	SNP	C	A	A			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr6:136597607C>A	uc003qgx.1	-	5	1309	c.1056G>T	c.(1054-1056)AGG>AGT	p.R352S	BCLAF1_uc003qgw.1_Intron|BCLAF1_uc003qgy.1_Missense_Mutation_p.R350S|BCLAF1_uc011edc.1_Intron|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.R350S	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	352					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TGGTATTACCCCTATCAAGCA	0.443000													9	523					0.000673444	0.000781528	0.008291	1	0
DNAH11	8701	broad.mit.edu	37	7	21678576	21678576	+	Missense_Mutation	SNP	G	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr7:21678576G>T	uc003svc.2	+	28	4883	c.4852G>T	c.(4852-4854)GCT>TCT	p.A1618S		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1618	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TTGTGAAAAAGCTCTCGCTGA	0.403000									Kartagener_syndrome				67	157					9.12251e-31	1.15881e-30	0.003610	1	0
ZNF713	349075	broad.mit.edu	37	7	56006946	56006946	+	Silent	SNP	A	C	C			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr7:56006946A>C	uc003trc.1	+	4	578	c.540A>C	c.(538-540)TCA>TCC	p.S180S	ZNF713_uc003tra.1_Silent_p.S193S|MRPS17_uc003trb.2_Intron	NM_182633	NP_872439	Q8N859	ZN713_HUMAN	zinc finger protein 713	180					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			ATCTGAACTCAAACCTTATGC	0.368000													32	136					0	0	0.002836	0	0
LOC643955	643955	broad.mit.edu	37	7	62758650	62758650	+	Missense_Mutation	SNP	A	G	G			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr7:62758650A>G	uc011kdj.1	-	2	228	c.160T>C	c.(160-162)TCC>CCC	p.S54P		NR_003952				Homo sapiens cDNA clone IMAGE:30377995, containing frame-shift errors.												0						TCACCCAGGGAGACCAAGTTT	0.358000													5	166					0	0	0.001168	0	0
CACNA2D1	781	broad.mit.edu	37	7	81624211	81624211	+	Silent	SNP	G	A	A			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr7:81624211G>A	uc003uhr.1	-	20	1963	c.1707C>T	c.(1705-1707)TTC>TTT	p.F569F		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	588	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CCAGAGTTCTGAATGTTTTTT	0.299000													6	112					0	0	0.001168	0	0
COL1A2	1278	broad.mit.edu	37	7	94033881	94033881	+	Missense_Mutation	SNP	C	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr7:94033881C>T	uc003ung.1	+	7	764	c.293C>T	c.(292-294)CCT>CTT	p.P98L	COL1A2_uc011kib.1_Missense_Mutation_p.P98L|COL1A2_uc010lfh.1_5'Flank	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	98					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TTAATGGGACCTAGAGGCCCA	0.443000										HNSCC(75;0.22)			4	163					0	0	0.000248	0	0
TRIM56	81844	broad.mit.edu	37	7	100732260	100732260	+	Missense_Mutation	SNP	C	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr7:100732260C>T	uc003uxq.2	+	3	1898	c.1667C>T	c.(1666-1668)GCC>GTC	p.A556V	TRIM56_uc003uxr.2_Intron	NM_030961	NP_112223	Q9BRZ2	TRI56_HUMAN	tripartite motif-containing 56	556					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|central_nervous_system(1)|skin(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)					TGCAGCGTGGCCGCCCTGCAG	0.672000													5	185					0	0	0.000602	0	0
TRPM6	140803	broad.mit.edu	37	9	77435280	77435280	+	Silent	SNP	A	G	G			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr9:77435280A>G	uc004ajl.1	-	9	1312	c.1074T>C	c.(1072-1074)AGT>AGC	p.S358S	TRPM6_uc004ajk.1_Silent_p.S353S|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Silent_p.S358S|TRPM6_uc010mpd.1_Silent_p.S358S|TRPM6_uc010mpe.1_Intron	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	358	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						ACTGTTTAAGACTAAAGTTGA	0.413000													35	108					0	0	0.008740	0	0
RMI1	80010	broad.mit.edu	37	9	86616940	86616940	+	Missense_Mutation	SNP	C	G	G			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr9:86616940C>G	uc004anq.3	+	3	1447	c.1039C>G	c.(1039-1041)CGA>GGA	p.R347G	RMI1_uc004anr.3_Missense_Mutation_p.R347G|RMI1_uc004anp.3_Missense_Mutation_p.R347G|RMI1_uc004ans.3_Missense_Mutation_p.R347G	NM_024945	NP_079221	Q9H9A7	RMI1_HUMAN	RMI1, RecQ mediated genome instability 1,	347					DNA replication	nucleus					0						AAATGCCGATCGAAGTATAGA	0.343000													16	100					0	0	0.003163	0	0
OR13C2	392376	broad.mit.edu	37	9	107367614	107367614	+	Missense_Mutation	SNP	C	A	A			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr9:107367614C>A	uc011lvq.1	-	1	295	c.295G>T	c.(295-297)GTG>TTG	p.V99L		NM_001004481	NP_001004481	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C,	99	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						AACATCTGCACTGCACAGCCA	0.522000													21	232					2.79863e-10	3.41651e-10	0.004656	1	0
ZNF618	114991	broad.mit.edu	37	9	116811471	116811471	+	Missense_Mutation	SNP	G	A	A			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr9:116811471G>A	uc004bid.2	+	15	1988	c.1889G>A	c.(1888-1890)GGC>GAC	p.G630D	ZNF618_uc004bic.2_Missense_Mutation_p.G537D|ZNF618_uc011lxi.1_Missense_Mutation_p.G597D|ZNF618_uc011lxj.1_Missense_Mutation_p.G598D|ZNF618_uc010mvb.2_Missense_Mutation_p.G220D	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	630					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCCAAGGCCGGCATGTGCCTT	0.622000													4	223					0	0	0.000602	0	0
COL27A1	85301	broad.mit.edu	37	9	116931516	116931516	+	Missense_Mutation	SNP	A	G	G			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr9:116931516A>G	uc011lxl.1	+	3	1681	c.1681A>G	c.(1681-1683)AAG>GAG	p.K561E	COL27A1_uc004bii.2_RNA|COL27A1_uc010mvd.1_Missense_Mutation_p.K411E	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	561	Pro-rich.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						CAGACCTGGGAAGGCAGCCAG	0.642000													9	242					0	0	0.004482	0	0
SPTAN1	6709	broad.mit.edu	37	9	131337005	131337005	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr9:131337005C>T	uc004bvl.3	+	4	528	c.415C>T	c.(415-417)CGA>TGA	p.R139*	SPTAN1_uc011mbg.1_Nonsense_Mutation_p.R139*|SPTAN1_uc011mbh.1_Nonsense_Mutation_p.R151*|SPTAN1_uc004bvm.3_Nonsense_Mutation_p.R139*|SPTAN1_uc004bvn.3_Nonsense_Mutation_p.R139*	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	139	Spectrin 2.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GGAGAAGATGCGAGAAAAAGG	0.468000													47	80					0	0	0.003610	0	0
CACNA1B	774	broad.mit.edu	37	9	140850187	140850187	+	Missense_Mutation	SNP	C	T	T			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr9:140850187C>T	uc004cog.2	+	8	1253	c.1108C>T	c.(1108-1110)CGC>TGC	p.R370C	CACNA1B_uc011mfd.1_5'Flank	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	370	Cytoplasmic (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GGAGAACCGCCGCGCCTTCCT	0.642000													10	17					0	0	0.008291	0	0
ATRX	546	broad.mit.edu	37	X	76890086	76890086	+	Missense_Mutation	SNP	T	C	C			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chrX:76890086T>C	uc004ecp.3	-	17	5040	c.4808A>G	c.(4807-4809)CAG>CGG	p.Q1603R	ATRX_uc004ecq.3_Missense_Mutation_p.Q1565R|ATRX_uc004eco.3_Missense_Mutation_p.Q1388R	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1603	Helicase ATP-binding.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	AGCTCTTACCTGTAAAGTCTT	0.294000			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						82	23					0	0	0.003610	0	0
VSIG1	340547	broad.mit.edu	37	X	107310285	107310285	+	Silent	SNP	T	C	C			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chrX:107310285T>C	uc004eno.2	+	3	494	c.333T>C	c.(331-333)AGT>AGC	p.S111S	VSIG1_uc011msk.1_Silent_p.S147S	NM_182607	NP_872413	Q86XK7	VSIG1_HUMAN	V-set and immunoglobulin domain containing 1	111	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						CAGCAGACAGTGGAATTTACA	0.463000													4	166					0	0	0.000248	0	0
Unknown	0	broad.mit.edu	37	1	700532	700532	+	RNA	DEL	T	-	-			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr1:700532delT	uc001abo.2	-	7		c.1022delA								Homo sapiens cDNA clone IMAGE:4129277, partial cds.																		aaaaaaaaaaTTCCTTTGGGA	0.214													4	6	---	---	---	---					
SLC8A3	6547	broad.mit.edu	37	14	70633381	70633382	+	Frame_Shift_Ins	INS	-	C	C			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr14:70633381_70633382insC	uc001xly.2	-	2	2512_2513	c.1758_1759insG	c.(1756-1761)GAGTTGfs	p.E586fs	SLC8A3_uc001xlw.2_Frame_Shift_Ins_p.E586fs|SLC8A3_uc001xlx.2_Frame_Shift_Ins_p.E586fs|SLC8A3_uc001xlz.2_Frame_Shift_Ins_p.E586fs|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	586_587	Calx-beta 2.|Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TTGAATTCCAACTCCCCATATG	0.505													14	120	---	---	---	---					
ZCCHC3	85364	broad.mit.edu	37	20	278688	278690	+	In_Frame_Del	DEL	CGG	-	-	rs5839847		TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr20:278688_278690delCGG	uc002wdf.2	+	1	485_487	c.461_463delCGG	c.(460-465)CCGGCG>CCG	p.A158del	ZCCHC3_uc002wdg.2_Intron	NM_033089	NP_149080	Q9NUD5	ZCHC3_HUMAN	zinc finger, CCHC domain containing 3	158	Poly-Ala.						nucleic acid binding|zinc ion binding				0		all_cancers(10;0.000209)|Lung NSC(37;0.0417)|all_lung(30;0.0713)|all_epithelial(17;0.0748)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			CAGGATGAgccggcggcggcggc	0.635													4	7	---	---	---	---					
LOC222699	222699	broad.mit.edu	37	6	28185337	28185339	+	RNA	DEL	TTT	-	-			TCGA-DH-5142-01A-01D-1468-08	TCGA-DH-5142-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	3a80ae1c-948a-4a98-b0c2-f81ab2415083	25f1462b-2671-4f5d-85e0-9539594b53e4	g.chr6:28185337_28185339delTTT	uc011dla.1	-	1		c.1369_1371delAAA				NR_002936				Homo sapiens pp14762 mRNA, complete cds.												0						ccttttcctcttttttttttttt	0.369													4	5	---	---	---	---					
