Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LOC440563	440563	broad.mit.edu	37	1	13183413	13183413	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr1:13183413G>A	uc010obg.1	-	1	555	c.460C>T	c.(460-462)CGA>TGA	p.R154*		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	154						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						TTGCCCCTTCGTGAGGTGTTT	0.512000													61	220					0	0	0.870114	0	0
NRD1	4898	broad.mit.edu	37	1	52301821	52301821	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr1:52301821C>T	uc001ctc.3	-	5	1220	c.898G>A	c.(898-900)GCA>ACA	p.A300T	NRD1_uc009vzb.2_5'UTR|NRD1_uc001ctd.3_Missense_Mutation_p.A232T|NRD1_uc001cte.2_Missense_Mutation_p.A168T|NRD1_uc001ctf.2_Missense_Mutation_p.A232T|NRD1_uc010ong.1_RNA|NRD1_uc009vzc.1_Missense_Mutation_p.A100T	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	231					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						AAAAAGTGTGCCAGCCCCGGC	0.418000													3	32					0	0	0.150653	0	0
SFRS11	9295	broad.mit.edu	37	1	70687521	70687521	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr1:70687521G>A	uc001des.2	+	2	326	c.202G>A	c.(202-204)GAT>AAT	p.D68N	SFRS11_uc009wbi.2_Missense_Mutation_p.D68N|SFRS11_uc009wbj.1_Missense_Mutation_p.D68N|SFRS11_uc010oqo.1_Missense_Mutation_p.D68N|SFRS11_uc001det.2_Missense_Mutation_p.D68N|SFRS11_uc001deu.2_Missense_Mutation_p.D68N	NM_004768	NP_004759	Q05519	SRS11_HUMAN	splicing factor, arginine/serine-rich 11	68	RRM.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0						CTTCCCGCCGGAGTGAGTATC	0.587000													11	40					0	0	0.387290	0	0
ABCA4	24	broad.mit.edu	37	1	94486867	94486867	+	Silent	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr1:94486867G>A	uc001dqh.2	-	35	5051	c.4947C>T	c.(4945-4947)CCC>CCT	p.P1649P	ABCA4_uc009wdp.1_5'Flank	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1649	Extracellular.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CATACTCCTCGGGGCTCCTGT	0.557000													47	84					0	0	0.870114	0	0
PPM1J	333926	broad.mit.edu	37	1	113252867	113252867	+	Missense_Mutation	SNP	C	T	T	rs113935705	byFrequency	TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr1:113252867C>T	uc001ect.1	-	10	1463	c.1436G>A	c.(1435-1437)CGT>CAT	p.R479H	RHOC_uc001ecq.1_5'Flank|RHOC_uc001ecr.1_5'Flank|RHOC_uc009wgk.1_5'Flank|PPM1J_uc009wgl.1_Intron|PPM1J_uc001ecs.1_Missense_Mutation_p.R273H	NM_005167	NP_005158	Q5JR12	PPM1J_HUMAN	protein phosphatase 1J (PP2C domain containing)	479	PP2C-like.									breast(2)|central_nervous_system(1)	3	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTTGGGGAGACGCCAGCCACG	0.622000													34	64					0	0	0.788014	0	0
SLAMF7	57823	broad.mit.edu	37	1	160719612	160719612	+	Silent	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr1:160719612G>A	uc001fwq.2	+	3	393	c.378G>A	c.(376-378)GAG>GAA	p.E126E	SLAMF7_uc010pjn.1_Silent_p.E19E|SLAMF7_uc001fws.2_Silent_p.E19E|SLAMF7_uc001fwr.2_Silent_p.E126E|SLAMF7_uc010pjo.1_Intron|SLAMF7_uc010pjp.1_Silent_p.E19E|SLAMF7_uc010pjq.1_Intron|SLAMF7_uc010pjr.1_Silent_p.E19E	NM_021181	NP_067004	Q9NQ25	SLAF7_HUMAN	SLAM family member 7	126	Extracellular (Potential).				cell adhesion|natural killer cell activation|natural killer cell mediated cytotoxicity	integral to membrane	receptor activity			skin(2)|ovary(1)	3	all_cancers(52;2.63e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CTCTCACAGAGCACCTGTCAA	0.493000													51	84					0	0	0.870114	0	0
F5	2153	broad.mit.edu	37	1	169512193	169512193	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr1:169512193C>T	uc001ggg.1	-	13	2280	c.2135G>A	c.(2134-2136)CGT>CAT	p.R712H		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	712	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	AGGTTCTAAACGATCATGCAT	0.403000													75	147					0	0	0.870114	0	0
SLC35F3	148641	broad.mit.edu	37	1	234041367	234041367	+	Missense_Mutation	SNP	C	T	T	rs146928346		TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr1:234041367C>T	uc001hvy.1	+	2	291	c.146C>T	c.(145-147)GCG>GTG	p.A49V		NM_173508	NP_775779	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	Error:Variant_position_missing_in_Q8IY50_after_alignment					transport	integral to membrane				ovary(2)	2	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			GTGGACGAGGCGATTAAGGAG	0.647000													18	43					0	0	0.575678	0	0
OR14C36	127066	broad.mit.edu	37	1	248512354	248512354	+	Missense_Mutation	SNP	C	T	T	rs145207343		TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr1:248512354C>T	uc010pzl.1	+	1	278	c.278C>T	c.(277-279)GCG>GTG	p.A93V		NM_001001918	NP_001001918	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						ATTTCTAAGGCGGGATGTGTA	0.473000													21	29					0	0	0.608945	0	0
YME1L1	10730	broad.mit.edu	37	10	27411836	27411836	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr10:27411836C>A	uc001iti.2	-	12	1522	c.1340G>T	c.(1339-1341)AGA>ATA	p.R447I	YME1L1_uc001itj.2_Missense_Mutation_p.R390I|YME1L1_uc010qdl.1_Missense_Mutation_p.R357I|YME1L1_uc009xkv.2_Intron	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	447					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						AGATTCAATTCTCTTCCCACC	0.348000													29	22					5.77227e-19	6.23405e-19	0.729181	1	0
RET	5979	broad.mit.edu	37	10	43595972	43595972	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr10:43595972G>A	uc001jal.2	+	2	329	c.139G>A	c.(139-141)GGC>AGC	p.G47S	RET_uc001jak.1_Missense_Mutation_p.G47S	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	47	Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	CCAGGCAGCCGGCACGCCCTT	0.627000		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				26	7					0	0	0.667858	0	0
C10orf71	118461	broad.mit.edu	37	10	50531225	50531225	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr10:50531225C>T	uc010qgp.1	+	3	974	c.635C>T	c.(634-636)CCA>CTA	p.P212L		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	212											0						AGCTACCAGCCAGGCAGGAAG	0.547000													5	10					0	0	0.184627	0	0
COL17A1	1308	broad.mit.edu	37	10	105803313	105803313	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr10:105803313C>T	uc001kxr.2	-	35	2630	c.2461G>A	c.(2461-2463)GGC>AGC	p.G821S		NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	821	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		CCTGGGGGGCCTGGGACAGTG	0.572000													20	7					0	0	0.575678	0	0
MUC5B	727897	broad.mit.edu	37	11	1268697	1268697	+	Silent	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr11:1268697C>T	uc009ycr.1	+	50	12297	c.12171C>T	c.(12169-12171)ACC>ACT	p.T4057T	MUC5B_uc001ltb.2_Silent_p.T3532T	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	3529	7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGACGACCACCCCGGGCCACA	0.687000													22	43					0	0	0.693898	0	0
OR51A4	401666	broad.mit.edu	37	11	4967723	4967723	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr11:4967723A>G	uc010qys.1	-	1	608	c.608T>C	c.(607-609)TTT>TCT	p.F203S		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,	203	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAGTGCTCCAAAAAAGCCATA	0.418000													23	56					0	0	0.740014	0	0
POLR2G	5436	broad.mit.edu	37	11	62530370	62530370	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr11:62530370G>A	uc001nva.2	+	3	264	c.154G>A	c.(154-156)GAC>AAC	p.D52N	POLR2G_uc001nvb.2_RNA	NM_002696	NP_002687	P62487	RPB7_HUMAN	DNA directed RNA polymerase II polypeptide G	52					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA-directed RNA polymerase activity|protein binding|RNA binding				0						CACCACCATTGACAATATTGG	0.468000													33	63					0	0	0.788014	0	0
SLC22A10	387775	broad.mit.edu	37	11	63064782	63064782	+	Nonsense_Mutation	SNP	C	T	T	rs111381363		TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr11:63064782C>T	uc009yor.2	+	3	722	c.514C>T	c.(514-516)CGA>TGA	p.R172*	SLC22A10_uc010rmo.1_RNA|SLC22A10_uc001nwu.3_RNA|SLC22A10_uc010rmp.1_Intron	NM_001039752	NP_001034841	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	172	Cytoplasmic (Potential).					integral to membrane	transmembrane transporter activity			ovary(2)	2						CAGGTTTGGGCGAAGATTTAT	0.398000													38	58					0	0	0.834066	0	0
DPP3	10072	broad.mit.edu	37	11	66276620	66276620	+	Silent	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr11:66276620C>T	uc001oig.1	+	18	2174	c.2112C>T	c.(2110-2112)TTC>TTT	p.F704F	DPP3_uc001oif.1_Silent_p.F704F|DPP3_uc010rpe.1_Silent_p.F693F|DPP3_uc001oih.1_Missense_Mutation_p.S72F|BBS1_uc001oii.1_5'UTR|BBS1_uc010rpf.1_5'Flank|BBS1_uc010rpg.1_5'Flank|BBS1_uc001oij.1_5'Flank|BBS1_uc001oik.1_5'Flank|BBS1_uc001oil.1_5'Flank	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III	704					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2						CTGAGCGTTTCCCAGAGGATG	0.602000													21	32					0	0	0.608945	0	0
GAB2	9846	broad.mit.edu	37	11	77931439	77931439	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr11:77931439G>A	uc001ozh.2	-	9	1813	c.1813C>T	c.(1813-1815)CCT>TCT	p.P605S	GAB2_uc001ozg.2_Missense_Mutation_p.P567S	NM_080491	NP_536739	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2 isoform a	605					osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity			ovary(5)|lung(1)	6	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			CTCTTCTTAGGGGCAGGACTG	0.577000													26	37					0	0	0.717897	0	0
HTR3A	3359	broad.mit.edu	37	11	113860240	113860240	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr11:113860240C>T	uc010rxb.1	+	8	1539	c.1306C>T	c.(1306-1308)CCG>TCG	p.P436S	HTR3A_uc010rxa.1_Missense_Mutation_p.P404S|HTR3A_uc009yyx.2_RNA|HTR3A_uc010rxc.1_Missense_Mutation_p.P383S	NM_213621	NP_998786	P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A	398	Cytoplasmic (Potential).				digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	CGAGAAGAGCCCGAGGGACAG	0.637000													38	54					0	0	0.796494	0	0
OR6M1	390261	broad.mit.edu	37	11	123676254	123676254	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr11:123676254G>C	uc010rzz.1	-	1	804	c.804C>G	c.(802-804)GAC>GAG	p.D268E		NM_001005325	NP_001005325	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M,	268	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		CGGCCACCTTGTCATAATCCA	0.488000													29	54					0	0	0.717897	0	0
GDF3	9573	broad.mit.edu	37	12	7843233	7843233	+	Silent	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr12:7843233G>A	uc001qte.2	-	2	372	c.336C>T	c.(334-336)AAC>AAT	p.N112N		NM_020634	NP_065685	Q9NR23	GDF3_HUMAN	growth differentiation factor 3 precursor	112					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			skin(3)|ovary(1)|lung(1)|central_nervous_system(1)	6						TGGCAGACAGGTTAAAGTAGA	0.478000													18	42					0	0	0.575678	0	0
DPPA3	359787	broad.mit.edu	37	12	7867929	7867929	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr12:7867929G>A	uc001qtf.2	+	2	311	c.233G>A	c.(232-234)TGG>TAG	p.W78*		NM_199286	NP_954980	Q6W0C5	DPPA3_HUMAN	stella	78						cytoplasm|nucleus					0				Kidney(36;0.0887)		GAAGATGAGTGGCTTTACAGC	0.478000													13	24					0	0	0.411799	0	0
KLRA1	10748	broad.mit.edu	37	12	10746526	10746526	+	RNA	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr12:10746526C>T	uc010shf.1	-	5		c.887G>A			KLRA1_uc010shg.1_RNA|KLRA1_uc009zho.2_RNA|KLRA1_uc009zhn.2_RNA	NM_006611				Homo sapiens Ly-49L (LY49L) mRNA, complete cds.												0						CTGTTTACATCCCTTCCAGTC	0.363000													12	57					0	0	0.435327	0	0
STAT6	6778	broad.mit.edu	37	12	57501513	57501513	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr12:57501513C>T	uc009zpe.2	-	3	381	c.130G>A	c.(130-132)GGC>AGC	p.G44S	STAT6_uc009zpf.2_Missense_Mutation_p.G44S|STAT6_uc001sna.2_Missense_Mutation_p.G44S|STAT6_uc010srb.1_5'UTR|STAT6_uc010src.1_Intron|STAT6_uc010srd.1_Intron|STAT6_uc009zpg.2_Missense_Mutation_p.G93S	NM_003153	NP_003144	P42226	STAT6_HUMAN	signal transducer and activator of transcription	44					regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4						GCGTCGGAGCCGACCAGGAAC	0.602000													11	29					0	0	0.387290	0	0
GZMH	2999	broad.mit.edu	37	14	25076508	25076508	+	Silent	SNP	A	C	C			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr14:25076508A>C	uc001wpr.1	-	4	489	c.444T>G	c.(442-444)GGT>GGG	p.G148G	GZMH_uc010aly.1_Intron|GZMH_uc010alz.1_Intron	NM_033423	NP_219491	P20718	GRAH_HUMAN	granzyme H precursor	148	Peptidase S1.				apoptosis|cytolysis|proteolysis	cytoplasm	serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(265;0.0267)		TTGAGACATAACCCCAGCCAG	0.557000													8	47					0	0	0.479597	0	0
LOC646214	646214	broad.mit.edu	37	15	21936464	21936464	+	RNA	SNP	C	T	T	rs8025772	by1000genomes	TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr15:21936464C>T	uc010tzj.1	-	1		c.4276G>A				NR_027053				Homo sapiens mRNA for p21-activated kinase 2 variant protein.												0						GTTATGCAGACCATTTCTTTA	0.328000													10	53					0	0	0.335167	0	0
C15orf21	283651	broad.mit.edu	37	15	45848224	45848224	+	RNA	SNP	G	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr15:45848224G>T	uc010beg.1	+	6		c.1219G>T			C15orf21_uc010beh.1_RNA|C15orf21_uc010bei.1_RNA|C15orf21_uc010bej.1_RNA|C15orf21_uc001zvm.1_RNA|C15orf21_uc001zvn.1_RNA					Homo sapiens cDNA FLJ39426 fis, clone PROST2000505.												0		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;3.03e-17)|GBM - Glioblastoma multiforme(94;7.36e-07)		TGCAGATTTTGTTTAGCTTTT	0.318000			T	ETV1	prostate								6	13					0.00116845	0.00119049	0.217242	1	0
UBL7	84993	broad.mit.edu	37	15	74751068	74751068	+	Silent	SNP	A	G	G			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr15:74751068A>G	uc002axw.1	-	2	303	c.141T>C	c.(139-141)ATT>ATC	p.I47I	UBL7_uc002axx.1_Silent_p.I87I|UBL7_uc010bjr.1_Intron|UBL7_uc002axy.1_Silent_p.I47I|UBL7_uc002axz.1_Silent_p.I47I|uc002aya.2_5'Flank|uc002ayb.2_5'Flank	NM_032907	NP_116296	Q96S82	UBL7_HUMAN	ubiquitin-like 7	47	Ubiquitin-like.						protein binding			ovary(1)	1						GTTTGCCAGCAATAAGCTGCT	0.502000													8	125					0	0	0.278610	0	0
KIAA1199	57214	broad.mit.edu	37	15	81181824	81181824	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr15:81181824C>T	uc002bfw.1	+	9	1237	c.977C>T	c.(976-978)ACG>ATG	p.T326M	KIAA1199_uc010unn.1_Missense_Mutation_p.T326M	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	326										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						GTGGAGTGGACGGAGTGGTTC	0.483000													23	47					0	0	0.654019	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92706193	92706193	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr15:92706193G>A	uc002bqx.2	+	10	2162	c.1961G>A	c.(1960-1962)CGC>CAC	p.R654H	SLCO3A1_uc002bqy.2_Missense_Mutation_p.R654H|SLCO3A1_uc002bqz.1_Missense_Mutation_p.R596H	NM_013272	NP_037404	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family,	654	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			skin(1)	1	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			AACTATAAACGCTACATCAAA	0.547000													26	36					0	0	0.681144	0	0
SLC12A3	6559	broad.mit.edu	37	16	56928468	56928468	+	Silent	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr16:56928468C>T	uc010ccm.2	+	22	2576	c.2547C>T	c.(2545-2547)CTC>CTT	p.L849L	SLC12A3_uc002ekd.3_Silent_p.L858L|SLC12A3_uc010ccn.2_Silent_p.L857L	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	849	Cytoplasmic (Potential).		L -> H (in GS).		sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	TTCCCTATCTCCTTGGCCGCA	0.502000													7	9					0	0	0.307466	0	0
NUDT7	283927	broad.mit.edu	37	16	77775636	77775636	+	Missense_Mutation	SNP	G	A	A	rs35294368		TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr16:77775636G>A	uc010chd.2	+	4	575	c.506G>A	c.(505-507)CGT>CAT	p.R169H	NUDT7_uc010vnj.1_Missense_Mutation_p.R116H	NM_001105663	NP_001099133	P0C024	NUDT7_HUMAN	nudix motif 7	169	Nudix hydrolase.				nucleoside diphosphate metabolic process	peroxisome	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|magnesium ion binding|manganese ion binding			ovary(1)|kidney(1)	2						CTTGGTCACCGTTTTATTAAT	0.473000													24	38					0	0	0.654019	0	0
CDH13	1012	broad.mit.edu	37	16	83250986	83250986	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr16:83250986C>T	uc002fgx.2	+	5	640	c.520C>T	c.(520-522)CGG>TGG	p.R174W	CDH13_uc010vns.1_Missense_Mutation_p.R221W|CDH13_uc010vnt.1_5'UTR|CDH13_uc010vnu.1_Missense_Mutation_p.R135W	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	174	Cadherin 1.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		GTCCAAGTTCCGGCTCACTGG	0.463000													23	32					0	0	0.624587	0	0
OVCA2	124641	broad.mit.edu	37	17	1946242	1946242	+	Silent	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr17:1946242G>A	uc002ftx.2	+	2	593	c.528G>A	c.(526-528)GGG>GGA	p.G176G	DPH1_uc002ftr.1_Intron|DPH1_uc002fts.2_3'UTR|DPH1_uc002ftt.2_3'UTR|DPH1_uc010cjx.2_3'UTR|DPH1_uc010vqs.1_3'UTR|DPH1_uc002ftu.2_3'UTR|DPH1_uc002ftv.2_3'UTR|DPH1_uc002ftw.2_3'UTR	NM_080822	NP_543012	Q8WZ82	OVCA2_HUMAN	candidate tumor suppressor in ovarian cancer 2	176					response to retinoic acid	cytoplasm	hydrolase activity				0						ATGTTTTTGGGGACACTGACA	0.547000											OREG0024078	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	46					0	0	0.729181	0	0
RANGRF	29098	broad.mit.edu	37	17	8192897	8192897	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr17:8192897A>G	uc002gkv.2	+	4	546	c.428A>G	c.(427-429)AAT>AGT	p.N143S	SLC25A35_uc002gku.1_3'UTR|SLC25A35_uc002gkt.2_3'UTR|RANGRF_uc002gkw.2_Intron|RANGRF_uc002gky.2_3'UTR|RANGRF_uc002gkx.2_Missense_Mutation_p.N143S|SLC25A35_uc002gkz.1_RNA	NM_016492	NP_057576	Q9HD47	MOG1_HUMAN	RAN guanine nucleotide release factor	143					protein transport	cytoplasm|nucleus	guanyl-nucleotide exchange factor activity				0						CTTACCTTCAATCAGCCCCCG	0.567000													17	36					0	0	0.557998	0	0
MYOCD	93649	broad.mit.edu	37	17	12656007	12656007	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr17:12656007G>A	uc002gnn.2	+	10	1701	c.1402G>A	c.(1402-1404)GCT>ACT	p.A468T	MYOCD_uc002gno.2_Missense_Mutation_p.A468T|MYOCD_uc002gnp.1_Missense_Mutation_p.A372T|MYOCD_uc002gnq.2_Missense_Mutation_p.A187T	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	468	Ser-rich.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CCTGTCAGTCGCTGGGTCCCT	0.627000													23	44					0	0	0.654019	0	0
SREBF1	6720	broad.mit.edu	37	17	17721591	17721591	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr17:17721591G>A	uc002gru.1	-	6	1360	c.1166C>T	c.(1165-1167)ACT>ATT	p.T389I	SREBF1_uc002grp.1_5'UTR|SREBF1_uc002grq.1_5'UTR|SREBF1_uc002grr.1_Missense_Mutation_p.T135I|SREBF1_uc002grs.1_Missense_Mutation_p.T365I|SREBF1_uc002grt.1_Missense_Mutation_p.T419I|SREBF1_uc010cpp.1_Missense_Mutation_p.T365I|SREBF1_uc010cpq.1_Missense_Mutation_p.T389I	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	389	Interaction with LMNA (By similarity).|Cytoplasmic (Potential).|Leucine-zipper.				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1						GTGGACAGCAGTGCGCAGACT	0.333000													13	52					0	0	0.500413	0	0
FAM83G	644815	broad.mit.edu	37	17	18881610	18881610	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr17:18881610C>T	uc002guw.2	-	5	1536	c.1369G>A	c.(1369-1371)GCC>ACC	p.A457T	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	457										ovary(1)|central_nervous_system(1)	2						TGGTGCTGGGCGCTGGCCTGG	0.642000													7	10					0	0	0.278610	0	0
CXADRP3	440224	broad.mit.edu	37	18	14478282	14478282	+	RNA	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr18:14478282C>T	uc010xai.1	-	3		c.1282G>A				NR_024076				Homo sapiens cDNA clone IMAGE:30390722, containing frame-shift errors.												0						CTGAGGAGTGCGTTCAAAGTC	0.478000													11	31					0	0	0.361761	0	0
LAMA3	3909	broad.mit.edu	37	18	21402283	21402284	+	Missense_Mutation	DNP	AC	TT	TT			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr18:21402283_21402284AC>TT	uc002kuq.2	+	20	2458_2459	c.2372_2373AC>TT	c.(2371-2373)TAC>TTT	p.Y791F	LAMA3_uc002kur.2_Missense_Mutation_p.Y791F	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	791					cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATTCTGAGATACGTTAACCCTG	0.381000													24	59					0	0	0.115264	0	0
KIAA1632	57724	broad.mit.edu	37	18	43496145	43496145	+	Silent	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr18:43496145G>A	uc002lbm.2	-	19	3511	c.3411C>T	c.(3409-3411)CCC>CCT	p.P1137P	KIAA1632_uc002lbo.1_Silent_p.P1137P|KIAA1632_uc010xcq.1_5'UTR|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Silent_p.P12P	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	1137					autophagy						0						CCACTTCATTGGGCTGAGTGC	0.473000													9	32					0	0	0.335167	0	0
USE1	55850	broad.mit.edu	37	19	17327047	17327047	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr19:17327047G>A	uc002nfo.2	+	4	361	c.301G>A	c.(301-303)GAG>AAG	p.E101K	USE1_uc002nfn.2_Missense_Mutation_p.E101K|USE1_uc010eal.1_Missense_Mutation_p.E101K	NM_018467	NP_060937	Q9NZ43	USE1_HUMAN	unconventional SNARE in the ER 1 homolog	101	Cytoplasmic (Potential).				lysosomal transport|protein catabolic process|protein transport|secretion by cell|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane	protein binding				0						CACAGCCAGAGAGCGAGTGCC	0.607000													16	20					0	0	0.520397	0	0
LRRC4B	94030	broad.mit.edu	37	19	51020955	51020955	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr19:51020955G>A	uc002pss.2	-	3	2152	c.2015C>T	c.(2014-2016)GCG>GTG	p.A672V		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	672	Cytoplasmic (Potential).					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		GCTGTAGTGCGCCTTGAAGGC	0.692000													6	9					0	0	0.307466	0	0
KLK1	3816	broad.mit.edu	37	19	51323240	51323240	+	Missense_Mutation	SNP	T	G	G			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr19:51323240T>G	uc002ptk.1	-	4	587	c.548A>C	c.(547-549)GAT>GCT	p.D183A	KLK1_uc010ycg.1_RNA	NM_002257	NP_002248	P06870	KLK1_HUMAN	kallikrein 1 preproprotein	183	Peptidase S1.				proteolysis	nucleus	serine-type endopeptidase activity				0		all_neural(266;0.0199)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00399)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTTGCACTCATCATTAGGCAG	0.547000													12	30					0	0	0.411799	0	0
KLK15	55554	broad.mit.edu	37	19	51330300	51330300	+	Silent	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr19:51330300G>A	uc002ptl.2	-	3	346	c.315C>T	c.(313-315)AAC>AAT	p.N105N	KLK15_uc002ptm.2_Silent_p.N105N|KLK15_uc002ptn.2_Silent_p.N105N|KLK15_uc002pto.2_Silent_p.N104N|KLK15_uc010ych.1_RNA|KLK15_uc010yci.1_Silent_p.N104N|KLK15_uc010eod.2_RNA	NM_017509	NP_059979	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15 isoform 4	105	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)|breast(1)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		ACATGATGTCGTTGCGGTGGC	0.687000													36	43					0	0	0.812448	0	0
LILRA2	11027	broad.mit.edu	37	19	55086781	55086781	+	Silent	SNP	G	A	A	rs144206436		TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr19:55086781G>A	uc002qgg.3	+	5	803	c.714G>A	c.(712-714)GAG>GAA	p.E238E	LILRA2_uc010ern.2_Silent_p.E238E|LILRA2_uc002qgf.2_Silent_p.E238E|LILRA2_uc010yfe.1_Silent_p.E238E|LILRA2_uc010yff.1_Silent_p.E226E|LILRA2_uc010ero.2_Silent_p.E226E|LILRA2_uc010yfg.1_Intron	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	238	Ig-like C2-type 3.|Extracellular (Potential).				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		CCCCCGGGGAGAGCCTGACCC	0.577000													33	52					0	0	0.827153	0	0
PTPRH	5794	broad.mit.edu	37	19	55713502	55713502	+	Missense_Mutation	SNP	C	T	T	rs147691392	byFrequency	TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr19:55713502C>T	uc002qjq.2	-	6	1148	c.1075G>A	c.(1075-1077)GGG>AGG	p.G359R	PTPRH_uc010esv.2_Missense_Mutation_p.G181R|PTPRH_uc002qjs.2_Missense_Mutation_p.G366R	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	359	Extracellular (Potential).|Fibronectin type-III 4.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		TACAAACACCCGGGTTCAAGT	0.542000													45	61					0	0	0.864702	0	0
C2orf56	55471	broad.mit.edu	37	2	37468832	37468832	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr2:37468832G>T	uc002rqa.3	+	5	595	c.520G>T	c.(520-522)GTC>TTC	p.V174F	C2orf56_uc010ynj.1_RNA|C2orf56_uc002rqc.3_Intron|C2orf56_uc010ynk.1_Intron|C2orf56_uc010ynl.1_Missense_Mutation_p.V147F|C2orf56_uc010fah.2_Intron	NM_144736	NP_653337	Q7L592	MIDA_HUMAN	hypothetical protein LOC55471 isoform 1	174					mitochondrial respiratory chain complex I assembly	mitochondrion	enzyme binding|methyltransferase activity			central_nervous_system(1)	1		all_hematologic(82;0.21)				TAAAGAGAAGGTCCCGTTAGA	0.423000													13	25					2.62699e-14	2.75451e-14	0.479597	1	0
USP34	9736	broad.mit.edu	37	2	61468710	61468710	+	Silent	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr2:61468710C>T	uc002sbe.2	-	53	6784	c.6762G>A	c.(6760-6762)TCG>TCA	p.S2254S	USP34_uc002sbf.2_Silent_p.S404S	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	2254					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			GTAACTCTGACGAAACATCAA	0.328000													12	26					0	0	0.435327	0	0
PAX8	7849	broad.mit.edu	37	2	114002201	114002201	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr2:114002201C>A	uc010yxt.1	-	4	358	c.192G>T	c.(190-192)AGG>AGT	p.R64S	PAX8_uc010yxu.1_Missense_Mutation_p.R64S|PAX8_uc010yxv.1_Missense_Mutation_p.R64S|PAX8_uc002tjm.2_Missense_Mutation_p.R64S|PAX8_uc002tjn.2_Missense_Mutation_p.R64S|PAX8_uc010fku.1_Missense_Mutation_p.R64S|LOC654433_uc002tjq.3_Intron|LOC654433_uc010fks.2_Intron|LOC654433_uc010fkt.2_Intron|LOC654433_uc002tjr.3_Intron	NM_003466	NP_003457	Q06710	PAX8_HUMAN	paired box 8 isoform PAX8A	64	Paired.				branching involved in ureteric bud morphogenesis|cellular response to gonadotropin stimulus|central nervous system development|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|metanephric collecting duct development|metanephric comma-shaped body morphogenesis|metanephric distal convoluted tubule development|metanephric nephron tubule formation|metanephric S-shaped body morphogenesis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|otic vesicle development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric field specification|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of thyroid-stimulating hormone secretion|thyroid gland development|transcription, DNA-dependent	nucleoplasm	protein binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid-stimulating hormone receptor activity			ovary(1)|lung(1)	2						TCTCGTAGTACCTACTCCAAT	0.552000			T	PPARG	follicular thyroid		Thyroid dysgenesis 						29	109					2.08457e-15	2.22904e-15	0.750413	1	0
PROKR2	128674	broad.mit.edu	37	20	5283062	5283062	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr20:5283062G>A	uc010zqw.1	-	2	779	c.779C>T	c.(778-780)ACG>ATG	p.T260M	PROKR2_uc010zqx.1_Missense_Mutation_p.T260M|PROKR2_uc010zqy.1_Missense_Mutation_p.T260M	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	260	Cytoplasmic (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						AATCTGCTCCGTCTGGAACCC	0.607000										HNSCC(71;0.22)			5	22					0	0	0.217242	0	0
SLC24A3	57419	broad.mit.edu	37	20	19701644	19701644	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr20:19701644G>A	uc002wrl.2	+	17	1992	c.1795G>A	c.(1795-1797)GTC>ATC	p.V599I		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	599	Helical; (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1						GGTGTTCGGCGTCCACCTGAA	0.607000													4	44					0	0	0.150653	0	0
ITCH	83737	broad.mit.edu	37	20	33068913	33068913	+	Silent	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr20:33068913C>T	uc010geu.1	+	21	2310	c.2118C>T	c.(2116-2118)TCC>TCT	p.S706S	ITCH_uc002xak.2_Silent_p.S665S|ITCH_uc010zuj.1_Silent_p.S555S	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase	706	HECT.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						TGTACTTCTCCGTTGACAAAG	0.313000													33	68					0	0	0.769981	0	0
PLCG1	5335	broad.mit.edu	37	20	39802384	39802384	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr20:39802384G>A	uc002xjp.1	+	29	3608	c.3487G>A	c.(3487-3489)GAG>AAG	p.E1163K	PLCG1_uc002xjo.1_Missense_Mutation_p.E1163K|PLCG1_uc010zwe.1_Missense_Mutation_p.E828K	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	1163	C2.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				CGTGGTGTATGAGGAAGACAT	0.517000											OREG0025953	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	106					0	0	0.435327	0	0
TTC3	7267	broad.mit.edu	37	21	38536430	38536430	+	Missense_Mutation	SNP	T	G	G			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr21:38536430T>G	uc002yvz.2	+	32	3353	c.3248T>G	c.(3247-3249)CTC>CGC	p.L1083R	TTC3_uc011aee.1_Missense_Mutation_p.L773R|TTC3_uc002ywa.2_Missense_Mutation_p.L1083R|TTC3_uc002ywb.2_Missense_Mutation_p.L1083R|TTC3_uc010gnf.2_Missense_Mutation_p.L848R|TTC3_uc002ywc.2_Missense_Mutation_p.L773R|TTC3_uc002ywd.1_Missense_Mutation_p.L147R	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1083					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				TTCGAAGCTCTCTATGACCAA	0.398000													15	56					0	0	0.457914	0	0
HRH1	3269	broad.mit.edu	37	3	11301013	11301013	+	Missense_Mutation	SNP	G	A	A	rs139664451	byFrequency	TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr3:11301013G>A	uc010hdr.2	+	2	632	c.290G>A	c.(289-291)CGT>CAT	p.R97H	HRH1_uc010hds.2_Missense_Mutation_p.R97H|HRH1_uc010hdt.2_Missense_Mutation_p.R97H|HRH1_uc003bwb.3_Missense_Mutation_p.R97H	NM_001098213	NP_001091683	P35367	HRH1_HUMAN	histamine receptor H1	97	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			large_intestine(1)|ovary(1)	2					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	TCACTGGGCCGTCCTCTCTGC	0.552000													88	103					0	0	0.870114	0	0
PBRM1	55193	broad.mit.edu	37	3	52651430	52651430	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr3:52651430G>A	uc003des.2	-	14	1678	c.1666C>T	c.(1666-1668)CCT>TCT	p.P556S	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.P556S|PBRM1_uc003der.2_Missense_Mutation_p.P524S|PBRM1_uc003det.2_Missense_Mutation_p.P571S|PBRM1_uc003deu.2_Missense_Mutation_p.P571S|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.P556S|PBRM1_uc010hmk.1_Missense_Mutation_p.P556S|PBRM1_uc003dey.2_Missense_Mutation_p.P556S|PBRM1_uc003dez.1_Missense_Mutation_p.P556S|PBRM1_uc003dfb.1_Missense_Mutation_p.P469S|PBRM1_uc003dfc.2_5'Flank	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	556	Bromo 4.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		TAATAATCAGGATAGTCCTTT	0.363000			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								22	38					0	0	0.639603	0	0
NBPF22P	285622	broad.mit.edu	37	5	85578422	85578422	+	Translation_Start_Site	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr5:85578422C>T	uc003kiq.2	+	1	161	c.-101C>T	c.(-103--99)GACGT>GATGT			NR_003719				SubName: Full=Putative uncharacterized protein NBPF22P;												0						AGTGTTGTGACGTGTTCATCA	0.418000													3	2					0	0	0.115264	0	0
BRD2	6046	broad.mit.edu	37	6	32947789	32947789	+	Missense_Mutation	SNP	T	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr6:32947789T>A	uc003ocn.3	+	11	3727	c.2026T>A	c.(2026-2028)TTA>ATA	p.L676I	BRD2_uc003ocq.3_Missense_Mutation_p.L676I|BRD2_uc003ocp.3_Missense_Mutation_p.L556I|BRD2_uc010juh.2_Missense_Mutation_p.L711I	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	676	ET.				spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						GGAGCCCTCTTTACGTGATTC	0.483000													14	33					0	0	0.479597	0	0
PACSIN1	29993	broad.mit.edu	37	6	34498365	34498365	+	Splice_Site	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr6:34498365G>A	uc003ojo.2	+	8	1243	c.1037_splice	c.e8+1	p.S346_splice	PACSIN1_uc003ojp.2_Splice_Site_p.S346_splice	NM_020804	NP_065855	Q9BY11	PACN1_HUMAN	protein kinase C and casein kinase substrate in						endocytosis		protein kinase activity				0						ACCGCGGCAGGTGAGTGCCTC	0.582000													9	10					0	0	0.307466	0	0
GPR115	221393	broad.mit.edu	37	6	47680159	47680159	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr6:47680159C>T	uc003oza.1	+	5	625	c.367C>T	c.(367-369)CGA>TGA	p.R123*	GPR115_uc003oyz.1_Nonsense_Mutation_p.R180*|GPR115_uc003ozb.1_Nonsense_Mutation_p.R121*	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	123	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						TCTAGACTTTCGAGCTCCAGA	0.423000													50	113					0	0	0.870114	0	0
FILIP1	27145	broad.mit.edu	37	6	76024624	76024624	+	Silent	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr6:76024624C>T	uc003pia.2	-	5	1297	c.924G>A	c.(922-924)TCG>TCA	p.S308S	FILIP1_uc003phy.1_Silent_p.S308S|FILIP1_uc003phz.2_Silent_p.S209S|FILIP1_uc010kbe.2_Silent_p.S311S|FILIP1_uc003pib.1_Silent_p.S60S	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	308	Potential.									skin(3)|ovary(1)	4						GAGAAAACCTCGAAGCCTTGT	0.418000													57	83					0	0	0.870114	0	0
HACE1	57531	broad.mit.edu	37	6	105232863	105232863	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr6:105232863G>A	uc003pqu.1	-	12	1683	c.1406C>T	c.(1405-1407)CCG>CTG	p.P469L	HACE1_uc010kcy.1_5'UTR|HACE1_uc010kcz.1_Missense_Mutation_p.P469L|HACE1_uc010kcx.1_5'UTR|HACE1_uc003pqt.1_Missense_Mutation_p.P122L	NM_020771	NP_065822	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing, E3	469					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			ovary(5)|lung(2)	7		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		TTCTTACCCCGGAGGCATCTG	0.348000													21	36					0	0	0.608945	0	0
SLC35F1	222553	broad.mit.edu	37	6	118635328	118635328	+	Missense_Mutation	SNP	A	C	C			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr6:118635328A>C	uc003pxx.3	+	8	1341	c.1140A>C	c.(1138-1140)TTA>TTC	p.L380F	SLC35F1_uc003pxy.1_Missense_Mutation_p.L185F	NM_001029858	NP_001025029	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	380					transport	integral to membrane				breast(1)	1				GBM - Glioblastoma multiforme(226;0.217)		TTGTGGACTTACCGACCACAG	0.597000													30	54					0	0	0.740014	0	0
COBL	23242	broad.mit.edu	37	7	51287614	51287614	+	Silent	SNP	T	G	G	rs145775268	by1000genomes	TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr7:51287614T>G	uc003tpr.3	-	2	254	c.69A>C	c.(67-69)CCA>CCC	p.P23P	COBL_uc003tps.2_Silent_p.P23P|COBL_uc011kcl.1_Silent_p.P23P|COBL_uc010kzc.2_Silent_p.P23P|COBL_uc003tpt.2_Silent_p.P23P	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	23	Poly-Pro.									skin(3)|ovary(2)	5	Glioma(55;0.08)					TTCCAGGAGGTGGGGGAGCAC	0.552000													6	25					0	0	0.335167	0	0
EGFR	1956	broad.mit.edu	37	7	55221710	55221710	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr7:55221710C>T	uc003tqk.2	+	7	1000	c.754C>T	c.(754-756)CGC>TGC	p.R252C	EGFR_uc003tqh.2_Missense_Mutation_p.R252C|EGFR_uc003tqi.2_Missense_Mutation_p.R252C|EGFR_uc003tqj.2_Missense_Mutation_p.R252C|EGFR_uc010kzg.1_Missense_Mutation_p.R207C|EGFR_uc011kco.1_Missense_Mutation_p.R199C|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	252	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)|p.R252C(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	ATAGGTCTGCCGCAAATTCCG	0.582000		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			40	140					0	0	0.847076	0	0
EGFR	1956	broad.mit.edu	37	7	55268101	55268101	+	Missense_Mutation	SNP	A	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr7:55268101A>T	uc003tqk.2	+	24	3187	c.2941A>T	c.(2941-2943)ATT>TTT	p.I981F	EGFR_uc010kzg.1_Missense_Mutation_p.I936F|EGFR_uc011kco.1_Missense_Mutation_p.I928F	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	981	Cytoplasmic (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CTACCTTGTCATTCAGGTACA	0.517000		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			16	854					0	0	0.557998	0	0
AUTS2	26053	broad.mit.edu	37	7	70231260	70231260	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr7:70231260C>A	uc003tvw.3	+	9	2372	c.1629C>A	c.(1627-1629)TTC>TTA	p.F543L	AUTS2_uc003tvx.3_Missense_Mutation_p.F543L|AUTS2_uc011keg.1_5'UTR	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	543	His-rich.									ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		agcacacCTTCACGCCGTTCC	0.493000													15	17					0.000422831	0.000434912	0.500413	1	0
SPDYE5	442590	broad.mit.edu	37	7	75131000	75131000	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr7:75131000T>C	uc011kfy.1	+	6	1011	c.875T>C	c.(874-876)GTC>GCC	p.V292A		NM_001099435	NP_001092905	A6NIY4	SPDE5_HUMAN	speedy homolog E5	292	Arg-rich.										0						TCTCAGATAGTCCTGTTCCAG	0.592000													5	143					0	0	0.248553	0	0
STAG3	10734	broad.mit.edu	37	7	99795727	99795727	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr7:99795727G>A	uc003utx.1	+	12	1337	c.1182G>A	c.(1180-1182)ATG>ATA	p.M394I	STAG3_uc010lgs.1_Missense_Mutation_p.M182I|STAG3_uc011kjk.1_Missense_Mutation_p.M336I|STAG3_uc003uub.1_5'Flank	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	394	SCD.				chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TGGTTTCCATGGTCATGGACA	0.463000													22	49					0	0	0.693898	0	0
CUL1	8454	broad.mit.edu	37	7	148451085	148451085	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr7:148451085G>A	uc010lpg.2	+	3	684	c.158G>A	c.(157-159)TGT>TAT	p.C53Y	CUL1_uc003wey.2_Missense_Mutation_p.C53Y|CUL1_uc003wez.2_5'UTR	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	53					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			TATAACTACTGTACTAGTGTT	0.403000													12	22					0	0	0.479597	0	0
MLL3	58508	broad.mit.edu	37	7	151945288	151945288	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr7:151945288G>T	uc003wla.2	-	14	2450	c.2231C>A	c.(2230-2232)ACA>AAA	p.T744K		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	744					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ACCCTCAATTGTAGGAGTCAT	0.383000			N		medulloblastoma								5	169					1.23904e-05	1.2867e-05	0.184627	1	0
LETM2	137994	broad.mit.edu	37	8	38250441	38250441	+	Silent	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr8:38250441C>T	uc003xlm.1	+	3	459	c.288C>T	c.(286-288)GAC>GAT	p.D96D	LETM2_uc003xlk.2_Silent_p.D143D|LETM2_uc011lbn.1_Translation_Start_Site|LETM2_uc003xll.1_Silent_p.D96D|LETM2_uc003xln.1_Translation_Start_Site|LETM2_uc003xlo.1_Translation_Start_Site	NM_144652	NP_653253	Q2VYF4	LETM2_HUMAN	leucine zipper-EF-hand containing transmembrane	143	LETM1.|Mitochondrial intermembrane (Potential).					integral to membrane|mitochondrial inner membrane					0	all_cancers(2;6.77e-47)|all_epithelial(2;1.01e-50)|all_lung(3;1.25e-23)|Lung NSC(2;2.76e-23)|Colorectal(12;0.000442)|Esophageal squamous(3;0.00202)	all_lung(54;0.0657)|Hepatocellular(245;0.152)|Lung NSC(58;0.175)	Epithelial(3;1.17e-42)|all cancers(3;5.44e-38)|BRCA - Breast invasive adenocarcinoma(5;5.44e-27)|LUSC - Lung squamous cell carcinoma(2;7.12e-25)|Lung(2;4.49e-22)|COAD - Colon adenocarcinoma(9;0.114)			TTTGGATTGACGCCAAAGTTG	0.393000													21	43					0	0	0.608945	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885200	88885200	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr8:88885200G>C	uc003ydz.2	-	1	1097	c.1000C>G	c.(1000-1002)CAG>GAG	p.Q334E		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	334	WD 2.									ovary(1)	1						TAGCAGTCCTGGCCCACGGCC	0.572000													17	35					0	0	0.539581	0	0
SLC45A4	57210	broad.mit.edu	37	8	142228890	142228890	+	Silent	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr8:142228890G>A	uc003ywd.1	-	4	1004	c.696C>T	c.(694-696)TTC>TTT	p.F232F	SLC45A4_uc003ywc.1_Silent_p.F232F|SLC45A4_uc010meq.1_Silent_p.F230F	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	283					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CCTCGTCTGGGAAGGCAGGGA	0.677000													26	82					0	0	0.750413	0	0
SECISBP2	79048	broad.mit.edu	37	9	91954798	91954798	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr9:91954798A>G	uc004aqj.1	+	9	1312	c.1232A>G	c.(1231-1233)AAC>AGC	p.N411S	SECISBP2_uc011ltk.1_Missense_Mutation_p.N410S|SECISBP2_uc004aqk.1_Missense_Mutation_p.N338S|SECISBP2_uc010mqo.1_Missense_Mutation_p.N116S|SECISBP2_uc011ltl.1_Missense_Mutation_p.N343S	NM_024077	NP_076982	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	411					translation	nucleus	mRNA 3'-UTR binding			ovary(2)|skin(1)	3						GAATTTCCCAACCTGGCAGTT	0.398000													12	78					0	0	0.457914	0	0
ACE2	59272	broad.mit.edu	37	X	15580079	15580079	+	Silent	SNP	T	C	C			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chrX:15580079T>C	uc004cxa.1	-	18	2535	c.2367A>G	c.(2365-2367)GGA>GGG	p.G789G	ACE2_uc004cxb.2_Silent_p.G789G	NM_021804	NP_068576	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2 precursor	789	Cytoplasmic (Potential).				angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			ovary(3)	3	Hepatocellular(33;0.183)				Moexipril(DB00691)	GATTATTTTCTCCTTTGCTAA	0.323000													40	66					0	0	0.864702	0	0
FAM47C	442444	broad.mit.edu	37	X	37027911	37027911	+	Silent	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chrX:37027911G>A	uc004ddl.1	+	1	1442	c.1428G>A	c.(1426-1428)CCG>CCA	p.P476P		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	476										ovary(3)	3						ATCTCTGCCCGGAGCCTCCAG	0.622000													19	37					0	0	0.592651	0	0
ELK1	2002	broad.mit.edu	37	X	47497331	47497331	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chrX:47497331G>A	uc004dik.3	-	5	1227	c.905C>T	c.(904-906)GCT>GTT	p.A302V	ELK1_uc010nhv.2_Missense_Mutation_p.A302V|ELK1_uc010nhw.2_Missense_Mutation_p.A192V|ELK1_uc004dil.3_Intron	NM_001114123	NP_001107595	P19419	ELK1_HUMAN	ELK1 protein	302					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						AGGGCTGGAAGCCGCATGGCC	0.706000													3	7					0	0	0.150653	0	0
CACNA1F	778	broad.mit.edu	37	X	49088176	49088176	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chrX:49088176G>A	uc004dnb.2	-	2	301	c.239C>T	c.(238-240)CCT>CTT	p.P80L	CACNA1F_uc010nip.2_Missense_Mutation_p.P80L	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	80	I.|Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	CCGTCGCAGAGGATTGGCCAG	0.602000													13	39					0	0	0.479597	0	0
NLGN3	54413	broad.mit.edu	37	X	70389237	70389237	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chrX:70389237C>T	uc004dzb.2	+	7	2081	c.1777C>T	c.(1777-1779)CGA>TGA	p.R593*	NLGN3_uc004dzc.2_Nonsense_Mutation_p.R476*|NLGN3_uc011mps.1_Nonsense_Mutation_p.R573*|NLGN3_uc004dze.2_Nonsense_Mutation_p.R411*	NM_018977	NP_061850	Q9NZ94	NLGN3_HUMAN	neuroligin 3	613	Extracellular (Potential).				neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			ovary(1)	1	Renal(35;0.156)					ACCAAGGGTCCGAGATCATTA	0.527000													4	9					0	0	0.184627	0	0
ATRX	546	broad.mit.edu	37	X	76764056	76764056	+	Missense_Mutation	SNP	A	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chrX:76764056A>T	uc004ecp.3	-	35	7484	c.7252T>A	c.(7252-7254)TAC>AAC	p.Y2418N	ATRX_uc004ecq.3_Missense_Mutation_p.Y2380N|ATRX_uc004eco.3_Missense_Mutation_p.Y2203N	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	2418					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TGCTGATTGTACTGCTGCTGG	0.413000			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						79	137					0	0	0.870114	0	0
TGIF2LX	90316	broad.mit.edu	37	X	89177201	89177201	+	Missense_Mutation	SNP	T	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chrX:89177201T>A	uc004efe.2	+	2	166	c.117T>A	c.(115-117)GAT>GAA	p.D39E		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	39						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						ATAACGCAGATACAGGCAGAG	0.547000													20	37					0	0	0.834066	0	0
PCDH11X	27328	broad.mit.edu	37	X	91090535	91090535	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chrX:91090535C>T	uc004efk.1	+	1	877	c.32C>T	c.(31-33)GCG>GTG	p.A11V	PCDH11X_uc004efl.1_Missense_Mutation_p.A11V|PCDH11X_uc004efo.1_Missense_Mutation_p.A11V|PCDH11X_uc010nmv.1_Missense_Mutation_p.A11V|PCDH11X_uc004efm.1_Missense_Mutation_p.A11V|PCDH11X_uc004efn.1_Missense_Mutation_p.A11V|PCDH11X_uc004efh.1_Missense_Mutation_p.A11V|PCDH11X_uc004efj.1_Missense_Mutation_p.A11V	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	11					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						TACATTTTCGCGGTCCTGCTA	0.493000													4	93					0	0	0.150653	0	0
PCDH11X	27328	broad.mit.edu	37	X	91133712	91133712	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chrX:91133712G>A	uc004efk.1	+	2	3318	c.2473G>A	c.(2473-2475)GTT>ATT	p.V825I	PCDH11X_uc004efl.1_Missense_Mutation_p.V825I|PCDH11X_uc004efo.1_Missense_Mutation_p.V825I|PCDH11X_uc010nmv.1_Missense_Mutation_p.V825I|PCDH11X_uc004efm.1_Missense_Mutation_p.V825I|PCDH11X_uc004efn.1_Missense_Mutation_p.V825I|PCDH11X_uc004efh.1_Missense_Mutation_p.V825I|PCDH11X_uc004efj.1_Missense_Mutation_p.V825I	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	825	Helical; (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CATAACTGTCGTTGTAGTTAT	0.463000													38	56					0	0	0.870114	0	0
BTK	695	broad.mit.edu	37	X	100613413	100613413	+	Silent	SNP	C	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chrX:100613413C>A	uc004ehg.2	-	12	1180	c.987G>T	c.(985-987)GGG>GGT	p.G329G	BTK_uc004ehf.2_5'UTR|BTK_uc010nnh.2_RNA|BTK_uc010nni.2_RNA|BTK_uc004ehe.2_RNA|BTK_uc010nnj.2_RNA|BTK_uc010nnk.2_RNA|BTK_uc010nnl.2_5'UTR|BTK_uc010nnm.2_5'UTR|BTK_uc010nnn.2_Silent_p.G329G|BTK_uc010nno.2_Silent_p.G363G|BTK_uc004ehh.1_RNA|BTK_uc004ehi.2_Silent_p.G329G	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	329	SH2.				calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						GACGTATCACCCCTTGAGGGT	0.473000									Agammaglobulinemia_X-linked				42	67					1.59361e-14	1.68735e-14	0.827153	1	0
GPRASP1	9737	broad.mit.edu	37	X	101909474	101909474	+	Silent	SNP	A	G	G			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chrX:101909474A>G	uc004ejj.3	+	5	1434	c.633A>G	c.(631-633)GCA>GCG	p.A211A	GPRASP1_uc004eji.3_Silent_p.A211A|GPRASP1_uc010nod.2_Silent_p.A211A	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	211						cytoplasm	protein binding			ovary(1)|lung(1)	2						AGGTCACTGCAAAATTTCATC	0.443000													13	254					0	0	0.457914	0	0
OCRL	4952	broad.mit.edu	37	X	128692669	128692669	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chrX:128692669C>A	uc004euq.2	+	7	664	c.499C>A	c.(499-501)CAA>AAA	p.Q167K	OCRL_uc004eur.2_Missense_Mutation_p.Q167K	NM_000276	NP_000267	Q01968	OCRL_HUMAN	phosphatidylinositol polyphosphate 5-phosphatase	167					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			lung(2)|ovary(1)|kidney(1)	4						AATAAATTCACAAAATCAGCC	0.393000													3	71					0.004672	0.00471566	0.115264	1	0
SLC9A6	10479	broad.mit.edu	37	X	135112296	135112296	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chrX:135112296G>C	uc004ezj.2	+	13	1602	c.1526G>C	c.(1525-1527)GGT>GCT	p.G509A	SLC9A6_uc004ezk.2_Missense_Mutation_p.G541A	NM_006359	NP_006350	Q92581	SL9A6_HUMAN	solute carrier family 9 (sodium/hydrogen	509					regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					TTTAGGGTTGGTGTTGATTCA	0.358000													22	69					0	0	0.624587	0	0
GPR112	139378	broad.mit.edu	37	X	135405491	135405491	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chrX:135405491G>A	uc004ezu.1	+	5	916	c.625G>A	c.(625-627)GAA>AAA	p.E209K	GPR112_uc010nsb.1_Intron	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	209	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					AGTTAGTTGGGAAGAAGACGT	0.438000													35	123					0	0	0.779181	0	0
SPANXN1	494118	broad.mit.edu	37	X	144337223	144337223	+	Silent	SNP	C	T	T			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chrX:144337223C>T	uc004fcb.2	+	2	108	c.108C>T	c.(106-108)CCC>CCT	p.P36P		NM_001009614	NP_001009614	Q5VSR9	SPXN1_HUMAN	SPANX-N1 protein	36											0	Acute lymphoblastic leukemia(192;6.56e-05)					ACTTAGCCCCCGAACCGAGTT	0.403000													35	52					0	0	0.796494	0	0
F8	2157	broad.mit.edu	37	X	154065952	154065952	+	Nonsense_Mutation	SNP	G	A	A	rs137852354		TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chrX:154065952G>A	uc004fmt.2	-	26	7147	c.6976C>T	c.(6976-6978)CGA>TGA	p.R2326*	F8_uc004fms.2_Nonsense_Mutation_p.R191*	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	2326	F5/8 type C 2.		R -> Q (in HEMA; moderate/mild; may cause reduced phospholipid binding).|R -> G (in HEMA).|R -> L (in HEMA; severe/moderate; may cause reduced phospholipid binding).|R -> P (in HEMA; severe sporadic).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	GGGTGAATTCGAAGGTAGCGA	0.527000													7	23					0	0	0.278610	0	0
AIM2	9447	broad.mit.edu	37	1	159032502	159032504	+	In_Frame_Del	DEL	TAA	-	-			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr1:159032502_159032504delTAA	uc001ftj.1	-	6	1255_1257	c.1010_1012delTTA	c.(1009-1014)ATTAAG>AAG	p.I337del		NM_004833	NP_004824	O14862	AIM2_HUMAN	absent in melanoma 2	337	HIN-200.				cellular response to drug|immune response|interleukin-1 beta secretion	mitochondrion|nucleus				ovary(2)|pancreas(1)	3	all_hematologic(112;0.0429)					TTTTTGGCCTTAATAACCTGGAT	0.399													17	54	---	---	---	---					
LOC651250	651250	broad.mit.edu	37	17	66131384	66131384	+	RNA	DEL	T	-	-			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr17:66131384delT	uc002jgq.2	+	6		c.10507delT			LOC651250_uc002kit.2_RNA|LOC651250_uc002jgo.1_Intron	NR_027418				Homo sapiens cDNA FLJ33831 fis, clone CTONG2003937.												0						TGCCAGGTGCTTCATGGGCTC	0.587													2	4	---	---	---	---					
RBM5	10181	broad.mit.edu	37	3	50155888	50155889	+	Frame_Shift_Del	DEL	GA	-	-			TCGA-DU-5852-01A-11D-1705-08	TCGA-DU-5852-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c81bf20-05e8-4fae-8585-c192e8084231	f1c56802-8ab9-48c7-856a-af4aac8aebe7	g.chr3:50155888_50155889delGA	uc003cyg.2	+	25	2595_2596	c.2447_2448delGA	c.(2446-2448)TGAfs	p.*816fs	RBM5_uc011bdk.1_Frame_Shift_Del_p.*644fs|RBM5_uc003cyh.2_Frame_Shift_Del_p.*273fs|uc003cyi.1_Intron	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5	816					apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GAGATGgagtgagagagagaga	0.470													8	14	---	---	---	---					
