Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ARHGEF16	27237	broad.mit.edu	37	1	3394457	3394457	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr1:3394457G>A	uc001akg.3	+	11	1740	c.1492G>A	c.(1492-1494)GCC>ACC	p.A498T	ARHGEF16_uc001aki.2_Missense_Mutation_p.A210T|ARHGEF16_uc001akj.2_Missense_Mutation_p.A210T|ARHGEF16_uc010nzh.1_Missense_Mutation_p.A202T	NM_014448	NP_055263	Q5VV41	ARHGG_HUMAN	Rho guanine exchange factor 16	498					activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			ovary(1)	1	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		ACTGATCTCTGCCTCCCGGTG	0.622000													20	51					0	0	0.014323	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr1:16918653C>T	uc009vos.1	-	6	853	c.-35_splice	c.e6+1		NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672							cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													4	43					0	0	0.001168	0	0
ADCY10	55811	broad.mit.edu	37	1	167791265	167791265	+	Missense_Mutation	SNP	A	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr1:167791265A>T	uc001ger.2	-	30	4581	c.4283T>A	c.(4282-4284)ATC>AAC	p.I1428N	ADCY10_uc009wvj.2_RNA|ADCY10_uc009wvk.2_Missense_Mutation_p.I1336N|ADCY10_uc010plj.1_Missense_Mutation_p.I1275N	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	1428					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						TTGTTACCAGATAGCTACAGA	0.353000													14	34					0	0	0.004990	0	0
TNNI1	7135	broad.mit.edu	37	1	201384346	201384346	+	Silent	SNP	G	A	A			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr1:201384346G>A	uc010ppq.1	-	4	145	c.52C>T	c.(52-54)CTG>TTG	p.L18L	TNNI1_uc001gwo.1_RNA|TNNI1_uc001gwp.2_5'UTR	NM_003281	NP_003272	P19237	TNNI1_HUMAN	troponin I, skeletal, slow	18	Involved in binding TNC.				muscle filament sliding|regulation of striated muscle contraction	cytosol|troponin complex	actin binding|tropomyosin binding				0						CTCACCTTCAGCAAGAGTTTG	0.582000													7	23					0	0	0.003080	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	Missense_Mutation	SNP	A	G	G	rs2257765		TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr10:38654432A>G	uc010qex.1	+	5	599	c.524A>G	c.(523-525)AAT>AGT	p.N175S	HSD17B7P2_uc001izq.2_RNA|HSD17B7P2_uc001izo.1_RNA|HSD17B7P2_uc001izp.1_Missense_Mutation_p.N173S					SubName: Full=cDNA FLJ60462, highly similar to 3-keto-steroid reductase (EC 1.1.1.270);												0						TCATCTCGCAATGCAAGGAAA	0.453000													5	91					0	0	0.000602	0	0
MRVI1	10335	broad.mit.edu	37	11	10622600	10622600	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr11:10622600G>A	uc010rcc.1	-	15	2268	c.1882C>T	c.(1882-1884)CGC>TGC	p.R628C	MRVI1_uc001miw.2_Missense_Mutation_p.R619C|MRVI1_uc010rcb.1_Missense_Mutation_p.R620C|MRVI1_uc009ygb.1_Missense_Mutation_p.R313C|MRVI1_uc001mix.2_Missense_Mutation_p.R313C|MRVI1_uc001miz.2_Missense_Mutation_p.R537C|MRVI1_uc009ygc.1_Missense_Mutation_p.R537C|MRVI1_uc010rcd.1_Missense_Mutation_p.R422C|MRVI1_uc009ygd.1_Missense_Mutation_p.R313C|MRVI1_uc010rce.1_RNA	NM_001100167	NP_001093637	Q9Y6F6	MRVI1_HUMAN	JAW1-related protein isoform c	601	Potential.				platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				ovary(2)|central_nervous_system(1)	3				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		TTCGACATGCGCTTTTCCTGC	0.507000													67	133					0	0	0.014410	0	0
OR5T3	390154	broad.mit.edu	37	11	56020051	56020051	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr11:56020051G>A	uc010rjd.1	+	1	376	c.376G>A	c.(376-378)GGA>AGA	p.G126R		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	126	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					TTCATTTATCGGATGTGCAAC	0.363000													52	95					0	0	0.014410	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57076923	57076923	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr11:57076923C>T	uc001njr.2	-	5	3574	c.3262G>A	c.(3262-3264)GGT>AGT	p.G1088S	TNKS1BP1_uc001njs.2_Missense_Mutation_p.G1088S|TNKS1BP1_uc009ymd.1_Missense_Mutation_p.G539S	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	1088	Gly-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				CTAAACTCACCGACCCAGCCT	0.642000													15	42					0	0	0.002450	0	0
NUMA1	4926	broad.mit.edu	37	11	71725528	71725528	+	Silent	SNP	C	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr11:71725528C>T	uc001orl.1	-	15	3193	c.3021G>A	c.(3019-3021)GCG>GCA	p.A1007A	NUMA1_uc009ysw.1_Silent_p.A570A|NUMA1_uc001ork.1_Intron|NUMA1_uc001orm.1_Silent_p.A1007A|NUMA1_uc001orn.2_Silent_p.A570A|NUMA1_uc009ysx.1_Silent_p.A1007A|NUMA1_uc001oro.1_Silent_p.A1007A	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1007	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						GGGTCAGCCGCGCCACCTCCC	0.687000			T	RARA	APL								31	71					0	0	0.012213	0	0
PIP4K2C	79837	broad.mit.edu	37	12	57989814	57989814	+	Silent	SNP	G	A	A			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr12:57989814G>A	uc001sou.2	+	4	644	c.513G>A	c.(511-513)CAG>CAA	p.Q171Q	PIP4K2C_uc001sot.2_Silent_p.Q171Q|PIP4K2C_uc010srs.1_Silent_p.Q153Q|PIP4K2C_uc010srt.1_Intron	NM_001146258	NP_001139730	Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	171	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)					ACTATCACCAGGTCAGGCCTC	0.478000													37	59					0	0	0.007835	0	0
WIF1	11197	broad.mit.edu	37	12	65460502	65460502	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr12:65460502G>A	uc001ssk.2	-	6	794	c.649C>T	c.(649-651)CGA>TGA	p.R217*		NM_007191	NP_009122	Q9Y5W5	WIF1_HUMAN	WNT inhibitory factor 1 precursor	217	EGF-like 2.				multicellular organismal development|Wnt receptor signaling pathway	extracellular region	protein tyrosine kinase activity			ovary(2)|lung(1)|skin(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0231)		TTCATACATCGTGGGGTACAA	0.428000			T	HMGA2	pleomorphic salivary gland adenoma								6	28					0	0	0.001168	0	0
WASF3	10810	broad.mit.edu	37	13	27257045	27257045	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr13:27257045C>T	uc001uqv.2	+	9	1510	c.1285C>T	c.(1285-1287)CGG>TGG	p.R429W	WASF3_uc001uqw.2_Missense_Mutation_p.R426W	NM_006646	NP_006637	Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	429					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			pancreas(1)	1	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		TGAGGCGAAGCGGCAAGAGCC	0.647000													27	34					0	0	0.013726	0	0
SOHLH2	54937	broad.mit.edu	37	13	36764136	36764136	+	Silent	SNP	G	A	A	rs144665592	byFrequency	TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr13:36764136G>A	uc001uvj.2	-	6	677	c.588C>T	c.(586-588)TTC>TTT	p.F196F	SOHLH2_uc010tei.1_Silent_p.F273F	NM_017826	NP_060296	Q9NX45	SOLH2_HUMAN	spermatogenesis and oogenesis specific basic	196					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;4.63e-08)|Epithelial(112;2.67e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|BRCA - Breast invasive adenocarcinoma(63;0.00685)|GBM - Glioblastoma multiforme(144;0.0273)		TGTTTTTCTCGAACTCTGACA	0.333000													23	26					0	0	0.003954	0	0
SLITRK6	84189	broad.mit.edu	37	13	86368978	86368978	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr13:86368978C>T	uc001vll.1	-	2	2125	c.1666G>A	c.(1666-1668)GAA>AAA	p.E556K	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	556	LRRCT 2.|Extracellular (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		GCTTTCAATTCCTTTTTGTCG	0.453000													37	57					0	0	0.006999	0	0
UPF3A	65110	broad.mit.edu	37	13	115047559	115047559	+	Silent	SNP	C	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr13:115047559C>T	uc001vup.2	+	2	308	c.271C>T	c.(271-273)CTG>TTG	p.L91L	UPF3A_uc010tkn.1_Silent_p.L91L|UPF3A_uc001vuq.2_Silent_p.L91L|UPF3A_uc001vus.2_RNA|UPF3A_uc001vur.2_RNA	NM_023011	NP_075387	Q9H1J1	REN3A_HUMAN	UPF3 regulator of nonsense transcripts homolog A	91	Required for interaction with UPF2.				mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			skin(1)	1	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)		GCTGCGCCCGCTGCCAGCACA	0.731000													3	4					0	0	0.004672	0	0
CIB2	10518	broad.mit.edu	37	15	78398161	78398161	+	Silent	SNP	C	T	T	rs117153558	byFrequency	TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr15:78398161C>T	uc002bdb.1	-	5	783	c.462G>A	c.(460-462)GAG>GAA	p.E154E	CIB2_uc002bdc.1_Silent_p.E111E|CIB2_uc010ums.1_Silent_p.E154E	NM_006383	NP_006374	O75838	CIB2_HUMAN	DNA-dependent protein kinase catalytic	154	EF-hand 3.						calcium ion binding				0						AGTCAGCCTCCTCAATGACCT	0.592000													3	59					0	0	0.009096	0	0
CCDC64B	146439	broad.mit.edu	37	16	3085393	3085393	+	Silent	SNP	G	A	A			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr16:3085393G>A	uc002ctf.3	-	1	150	c.105C>T	c.(103-105)GAC>GAT	p.D35D	CCDC64B_uc002cte.3_5'Flank	NM_001103175	NP_001096645	A1A5D9	BICR2_HUMAN	coiled-coil domain containing 64B	35											0						CCAGGAATGAGTCCCGCCGCT	0.692000													5	10					0	0	0.000602	0	0
OTOA	146183	broad.mit.edu	37	16	21702976	21702976	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr16:21702976C>G	uc002djh.2	+	8	708	c.707C>G	c.(706-708)ACT>AGT	p.T236S	uc002diq.3_Intron|OTOA_uc010vbj.1_Missense_Mutation_p.T157S	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	236					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		TCCTGGATGACTGGAATACTG	0.468000													14	30					0	0	0.004990	0	0
MYH3	4621	broad.mit.edu	37	17	10554966	10554966	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr17:10554966C>T	uc002gmq.1	-	4	445	c.368G>A	c.(367-369)TGT>TAT	p.C123Y		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	123	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						GACAGTGACACAGAAGAGGCC	0.493000													38	73					0	0	0.007835	0	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39262103	39262103	+	Missense_Mutation	SNP	A	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr17:39262103A>T	uc010wfp.1	+	1	463	c.463A>T	c.(463-465)AGC>TGC	p.S155C		NM_001146041	NP_001139513	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	155	29 X 5 AA repeats of C-C-[RQVHIEK]- [SPTR]-[VSTQCRNP].					keratin filament					0						ccccagctgcagcatctccag	0.124000													3	7					0	0	0.001168	0	0
G6PC	2538	broad.mit.edu	37	17	41059630	41059630	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr17:41059630C>T	uc002icb.1	+	3	510	c.431C>T	c.(430-432)CCG>CTG	p.P144L	G6PC_uc010whf.1_Silent_p.A120A	NM_000151	NP_000142	P35575	G6PC_HUMAN	glucose-6-phosphatase, catalytic subunit	144	Cytoplasmic (Potential).				gluconeogenesis|glucose homeostasis|transmembrane transport	integral to endoplasmic reticulum membrane	glucose-6-phosphatase activity|phosphate binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.113)		AAGATAAAGCCGACCTACAGA	0.527000									Glycogen_Storage_Disease_type_Ia				12	19					0	0	0.002450	0	0
SAMD14	201191	broad.mit.edu	37	17	48193445	48193445	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr17:48193445C>T	uc002iqg.2	-	5	808	c.509G>A	c.(508-510)CGT>CAT	p.R170H	SAMD14_uc002iqd.2_Translation_Start_Site|SAMD14_uc002iqe.2_Translation_Start_Site|SAMD14_uc002iqf.2_Missense_Mutation_p.R170H	NM_174920	NP_777580	Q8IZD0	SAM14_HUMAN	sterile alpha motif domain containing 14	170											0						ACTGGCGTCACGGCTGTCATC	0.532000													13	28					0	0	0.002450	0	0
GPRC5C	55890	broad.mit.edu	37	17	72436710	72436710	+	Silent	SNP	C	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr17:72436710C>T	uc002jks.2	+	1	834	c.795C>T	c.(793-795)TAC>TAT	p.Y265Y	GPRC5C_uc002jkp.2_Silent_p.Y310Y|GPRC5C_uc002jkq.2_Intron|GPRC5C_uc002jkr.2_Silent_p.Y277Y|GPRC5C_uc002jkt.2_Silent_p.Y265Y|GPRC5C_uc002jku.2_5'Flank	NM_018653	NP_061123	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor family C, group 5,	265	Extracellular (Potential).					cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			ovary(2)|prostate(1)|central_nervous_system(1)|pancreas(1)	5						TGTATACTTACGGCAACAAGC	0.607000													11	42					0	0	0.001855	0	0
ZNF333	84449	broad.mit.edu	37	19	14828520	14828520	+	Missense_Mutation	SNP	A	C	C			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr19:14828520A>C	uc002mzn.2	+	11	1009	c.875A>C	c.(874-876)GAG>GCG	p.E292A	ZNF333_uc002mzk.3_Missense_Mutation_p.E183A	NM_032433	NP_115809	Q96JL9	ZN333_HUMAN	zinc finger protein 333	292					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						ACTTTTACAGAGATCCTGTCC	0.418000													24	37					0	0	0.003954	0	0
GRLF1	2909	broad.mit.edu	37	19	47423551	47423551	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr19:47423551G>A	uc010ekv.2	+	1	1619	c.1619G>A	c.(1618-1620)CGT>CAT	p.R540H		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	540					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		CAAGCAGAGCGTGATGCCCTT	0.483000													49	100					0	0	0.014410	0	0
TSKS	60385	broad.mit.edu	37	19	50249906	50249906	+	Silent	SNP	G	A	A			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr19:50249906G>A	uc002ppm.2	-	6	824	c.813C>T	c.(811-813)AAC>AAT	p.N271N		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	271							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		GGCCCAGGCTGTTCCAGGAGA	0.443000													3	23					0	0	0.009096	0	0
TGM3	7053	broad.mit.edu	37	20	2321165	2321165	+	Missense_Mutation	SNP	G	A	A	rs140423684		TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr20:2321165G>A	uc002wfx.3	+	13	2117	c.2020G>A	c.(2020-2022)GAC>AAC	p.D674N		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	674				D -> G (in Ref. 2; BAF84040).	cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)	ACTGCTCGCCGACTTCTCCTG	0.602000													29	64					0	0	0.006320	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr20:33345744C>T	uc002xav.2	-	8	3378	c.807G>A	c.(805-807)CAG>CAA	p.Q269Q	NCOA6_uc002xaw.2_Silent_p.Q269Q|NCOA6_uc010gew.1_Silent_p.Q226Q	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	TBP/GTF2A-binding region.|NCOA1-binding region.|Gln-rich.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						gctgctgctgctgttgttgtt	0.313000													3	35					0	0	0.004672	0	0
EEF1A2	1917	broad.mit.edu	37	20	62127281	62127281	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr20:62127281C>G	uc002yfd.1	-	2	353	c.252G>C	c.(250-252)AAG>AAC	p.K84N	EEF1A2_uc002yfe.1_Missense_Mutation_p.K84N|EEF1A2_uc010gkg.1_Missense_Mutation_p.K84N	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	84						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			TGATGTAGTACTTGGTGGTCT	0.592000											OREG0026129	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	87					0	0	0.001168	0	0
JAM2	58494	broad.mit.edu	37	21	27062196	27062196	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr21:27062196A>G	uc002ylp.1	+	3	697	c.152A>G	c.(151-153)AAA>AGA	p.K51R	JAM2_uc011ace.1_Missense_Mutation_p.K51R|JAM2_uc002ylq.1_RNA|JAM2_uc011acf.1_Intron|JAM2_uc010glh.1_RNA|JAM2_uc002ylr.1_Missense_Mutation_p.K51R|JAM2_uc010gli.1_Missense_Mutation_p.K51R	NM_021219	NP_067042	P57087	JAM2_HUMAN	junctional adhesion molecule 2 precursor	51	Ig-like V-type.|Extracellular (Potential).				blood coagulation|cell-cell adhesion|leukocyte migration	integral to plasma membrane|tight junction					0						TTAGCCTGCAAAACCCCAAAG	0.368000													42	67					0	0	0.011902	0	0
DSCAM	1826	broad.mit.edu	37	21	41711192	41711192	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr21:41711192C>T	uc002yyq.1	-	7	1813	c.1361G>A	c.(1360-1362)CGC>CAC	p.R454H	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	454	Extracellular (Potential).|Ig-like C2-type 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CTGGCTGATGCGGTGACTGCC	0.602000													3	42					0	0	0.004672	0	0
SLC19A1	6573	broad.mit.edu	37	21	46951525	46951525	+	Silent	SNP	G	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr21:46951525G>T	uc002zhl.1	-	3	846	c.727C>A	c.(727-729)CGG>AGG	p.R243R	SLC19A1_uc010gpy.1_Silent_p.R243R|SLC19A1_uc011aft.1_Silent_p.R203R|SLC19A1_uc002zhm.1_Silent_p.R243R|SLC19A1_uc010gpz.1_Silent_p.R122R	NM_194255	NP_919231	P41440	S19A1_HUMAN	solute carrier family 19 member 1	243	Cytoplasmic (Probable).				folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity				0				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		CAGGCCACCCGCAGGGCGTGT	0.706000													22	38					3.7963e-18	4.05633e-18	0.003330	1	0
PCNT	5116	broad.mit.edu	37	21	47845846	47845846	+	Silent	SNP	C	T	T	rs138588682		TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr21:47845846C>T	uc002zji.3	+	33	7388	c.7281C>T	c.(7279-7281)GAC>GAT	p.D2427D	PCNT_uc002zjj.2_Silent_p.D2309D	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2427					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GGAAGGAAGACGAGATACAGG	0.552000													21	63					0	0	0.002780	0	0
HGD	3081	broad.mit.edu	37	3	120360508	120360508	+	Silent	SNP	G	A	A			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr3:120360508G>A	uc003edw.2	-	11	1177	c.807C>T	c.(805-807)CAC>CAT	p.H269H	HGD_uc003edv.2_Silent_p.H128H	NM_000187	NP_000178	Q93099	HGD_HUMAN	homogentisate 1,2-dioxygenase	269					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	homogentisate 1,2-dioxygenase activity|metal ion binding				0				GBM - Glioblastoma multiforme(114;0.158)		TATAATTCCCGTGCCAGGCCA	0.438000													19	60					0	0	0.010504	0	0
ENAM	10117	broad.mit.edu	37	4	71509397	71509397	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr4:71509397G>T	uc011caw.1	+	9	2535	c.2254G>T	c.(2254-2256)GCT>TCT	p.A752S		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	752					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			TAATAATGCCGCTGGACCAGA	0.453000													33	64					3.67414e-24	4.03638e-24	0.012213	1	0
ADAMTS3	9508	broad.mit.edu	37	4	73434466	73434466	+	Nonsense_Mutation	SNP	G	C	C			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr4:73434466G>C	uc003hgk.1	-	1	51	c.14C>G	c.(13-15)TCA>TGA	p.S5*		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	5					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CAACCAAAGTGACAGGAGAAC	0.448000													14	22					0	0	0.006122	0	0
CXCL9	4283	broad.mit.edu	37	4	76927403	76927403	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr4:76927403C>T	uc003hjh.1	-	2	128	c.89G>A	c.(88-90)CGC>CAC	p.R30H		NM_002416	NP_002407	Q07325	CXCL9_HUMAN	small inducible cytokine B9 precursor	30					cell-cell signaling|cellular defense response|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response	extracellular space	chemokine activity			ovary(1)	1			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GCAGGAACAGCGACCCTTTCT	0.433000													39	94					0	0	0.004289	0	0
SEC24D	9871	broad.mit.edu	37	4	119736623	119736623	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr4:119736623C>A	uc003ici.3	-	5	928	c.656G>T	c.(655-657)GGA>GTA	p.G219V	SEC24D_uc003icj.3_Missense_Mutation_p.G219V|SEC24D_uc003icl.2_RNA|SEC24D_uc010imz.1_RNA|SEC24D_uc011cgg.1_RNA	NM_014822	NP_055637	O94855	SC24D_HUMAN	Sec24-related protein D	219	Pro-rich.				COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0						CGGAGGATATCCAGCACCCAA	0.557000													21	36					3.62473e-10	3.82066e-10	0.012319	1	0
DCHS2	54798	broad.mit.edu	37	4	155287390	155287390	+	Silent	SNP	C	T	T	rs78251264	byFrequency	TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr4:155287390C>T	uc003inw.2	-	5	666	c.666G>A	c.(664-666)TCG>TCA	p.S222S	DCHS2_uc003inx.2_Silent_p.S816S	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	222	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TAAAAAGGGACGACACGTTTC	0.448000													6	46					0	0	0.001168	0	0
CLCN3	1182	broad.mit.edu	37	4	170601232	170601232	+	Silent	SNP	C	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr4:170601232C>T	uc003isi.2	+	3	701	c.192C>T	c.(190-192)AGC>AGT	p.S64S	CLCN3_uc003ish.2_Silent_p.S64S|CLCN3_uc011cjz.1_Silent_p.S47S|CLCN3_uc011cka.1_Silent_p.S64S|CLCN3_uc003isj.1_Silent_p.S37S	NM_001829	NP_001820	P51790	CLCN3_HUMAN	chloride channel 3 isoform b	64	Cytoplasmic (By similarity).				endosomal lumen acidification	cell surface|early endosome membrane|Golgi membrane|integral to membrane|late endosome membrane|transport vesicle membrane	antiporter activity|ATP binding|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(2)|ovary(1)	3		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)		ATGGAGGCAGCATTAACAGTT	0.368000													17	39					0	0	0.007413	0	0
MTRR	4552	broad.mit.edu	37	5	7875377	7875377	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr5:7875377G>A	uc003jed.2	+	4	401	c.371G>A	c.(370-372)GGT>GAT	p.G124D	MTRR_uc010itn.1_RNA|MTRR_uc003jee.3_Missense_Mutation_p.G97D|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	124	FMN (By similarity).|Flavodoxin-like.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	CTAGGTCTCGGTGATTCAGAA	0.348000													43	75					0	0	0.010771	0	0
FYB	2533	broad.mit.edu	37	5	39202453	39202453	+	Silent	SNP	G	A	A			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr5:39202453G>A	uc003jls.2	-	1	677	c.610C>T	c.(610-612)CTA>TTA	p.L204L	FYB_uc003jlt.2_Silent_p.L204L|FYB_uc003jlu.2_Silent_p.L204L|FYB_uc011cpl.1_Silent_p.L214L	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	204					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			TCGGTACTTAGGGGCGGCTTC	0.532000													33	37					0	0	0.003755	0	0
DDX4	54514	broad.mit.edu	37	5	55063741	55063741	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr5:55063741C>T	uc003jqg.3	+	7	441	c.367C>T	c.(367-369)CGG>TGG	p.R123W	DDX4_uc010ivz.2_Intron|DDX4_uc003jqh.3_Missense_Mutation_p.R123W|DDX4_uc003jqj.2_Missense_Mutation_p.R24W	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	123	Gly-rich.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				TAATCCAACACGGAACAGAGG	0.333000													17	38					0	0	0.014323	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202819	140202819	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr5:140202819G>A	uc003lhl.2	+	1	1459	c.1459G>A	c.(1459-1461)GCC>ACC	p.A487T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.A487T|PCDHA5_uc003lhj.1_Missense_Mutation_p.A487T	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	487	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGGAGAACGCCCTGGTGTC	0.662000													32	63					0	0	0.009718	0	0
PCDHB4	56131	broad.mit.edu	37	5	140503168	140503168	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr5:140503168G>A	uc003lip.1	+	1	1588	c.1588G>A	c.(1588-1590)GTG>ATG	p.V530M		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	530	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGAGTTCCGCGTGGGCGCCTC	0.672000													32	73					0	0	0.013726	0	0
GRM4	2914	broad.mit.edu	37	6	33996019	33996019	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr6:33996019C>T	uc003oir.3	-	9	2737	c.2567G>A	c.(2566-2568)CGC>CAC	p.R856H	GRM4_uc011dsn.1_Missense_Mutation_p.R809H|GRM4_uc010jvh.2_Missense_Mutation_p.R856H|GRM4_uc010jvi.2_Missense_Mutation_p.R548H|GRM4_uc003oio.2_Missense_Mutation_p.R548H|GRM4_uc003oip.2_RNA|GRM4_uc011dsl.1_Missense_Mutation_p.R716H|GRM4_uc003oiq.2_Missense_Mutation_p.R723H|GRM4_uc011dsm.1_Missense_Mutation_p.R687H	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	856	Cytoplasmic (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	GCTGCGCTTGCGCTTGGGCAC	0.602000													18	48					0	0	0.007413	0	0
CRHR2	1395	broad.mit.edu	37	7	30695575	30695575	+	Silent	SNP	G	A	A			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr7:30695575G>A	uc003tbn.2	-	9	1129	c.885C>T	c.(883-885)CGC>CGT	p.R295R	CRHR2_uc010kvw.1_Silent_p.R295R|CRHR2_uc010kvx.1_Silent_p.R294R|CRHR2_uc010kvy.1_Silent_p.R131R|CRHR2_uc003tbo.2_Silent_p.R281R|CRHR2_uc003tbp.2_Silent_p.R322R	NM_001883	NP_001874	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	295	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(2)|ovary(1)|skin(1)	4						TGGTGGACGCGCGTAACTTTG	0.552000													36	65					0	0	0.006999	0	0
Unknown	0	broad.mit.edu	37	7	38282029	38282029	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr7:38282029C>A	uc003tfu.3	-	4	476	c.241G>T	c.(241-243)GAT>TAT	p.D81Y	uc003tfv.2_Missense_Mutation_p.D81Y					SubName: Full=TARP protein;																		AAAAGCTTACCATTTGCATCT	0.313000													44	103					6.68952e-21	7.24698e-21	0.013114	1	0
EGFR	1956	broad.mit.edu	37	7	55221711	55221711	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr7:55221711G>C	uc003tqk.2	+	7	1001	c.755G>C	c.(754-756)CGC>CCC	p.R252P	EGFR_uc003tqh.2_Missense_Mutation_p.R252P|EGFR_uc003tqi.2_Missense_Mutation_p.R252P|EGFR_uc003tqj.2_Missense_Mutation_p.R252P|EGFR_uc010kzg.1_Missense_Mutation_p.R207P|EGFR_uc011kco.1_Missense_Mutation_p.R199P|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	252	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)|p.R252C(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TAGGTCTGCCGCAAATTCCGA	0.587000		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			705	183					0	0	0.014410	0	0
ASNS	440	broad.mit.edu	37	7	97498435	97498435	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr7:97498435C>G	uc003uot.3	-	3	540	c.34G>C	c.(34-36)GAT>CAT	p.D12H	ASNS_uc011kin.1_Intron|ASNS_uc003uou.3_Missense_Mutation_p.D12H|ASNS_uc003uov.3_Missense_Mutation_p.D12H|ASNS_uc011kio.1_Intron|ASNS_uc003uow.3_Intron|ASNS_uc003uox.3_Intron	NM_133436	NP_597680	P08243	ASNS_HUMAN	asparagine synthetase	12	Glutamine amidotransferase type-2.				cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding			ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GAAAGGCAATCATCACTGCCA	0.418000													15	74					0	0	0.006122	0	0
SOX7	83595	broad.mit.edu	37	8	10587872	10587872	+	Silent	SNP	C	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr8:10587872C>T	uc003wtf.2	-	1	151	c.72G>A	c.(70-72)TCG>TCA	p.S24S	SOX7_uc011kwz.1_Intron|uc003wtg.1_Intron	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	24					endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		ATTGTCCATCCGACAGCTCGG	0.577000													4	12					0	0	0.009096	0	0
ADAM28	10863	broad.mit.edu	37	8	24187575	24187575	+	Silent	SNP	C	T	T	rs151133749	byFrequency	TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr8:24187575C>T	uc003xdy.2	+	11	1133	c.1050C>T	c.(1048-1050)GAC>GAT	p.D350D	ADAM28_uc003xdx.2_Silent_p.D350D|ADAM28_uc011kzz.1_Silent_p.D117D|ADAM28_uc011laa.1_RNA|ADAM28_uc010lua.2_Silent_p.D37D	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	350	Peptidase M12B.|Extracellular (Potential).				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		TGTTTCATGACGACTATTCTT	0.453000													31	61					0	0	0.008361	0	0
TRPA1	8989	broad.mit.edu	37	8	72987644	72987644	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr8:72987644T>C	uc003xza.2	-	1	176	c.1A>G	c.(1-3)ATG>GTG	p.M1V		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	1	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	CTGCGCTTCATTGACCCCACC	0.667000													22	42					0	0	0.012319	0	0
FER1L6	654463	broad.mit.edu	37	8	125082819	125082819	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr8:125082819C>T	uc003yqw.2	+	30	4152	c.3946C>T	c.(3946-3948)CGA>TGA	p.R1316*	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1316	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TGATGGAGACCGAGTCATAGG	0.398000													49	86					0	0	0.014410	0	0
ANXA1	301	broad.mit.edu	37	9	75773611	75773611	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr9:75773611C>T	uc004ajf.1	+	3	141	c.67C>T	c.(67-69)CAA>TAA	p.Q23*	ANXA1_uc004aje.1_Nonsense_Mutation_p.Q23*|ANXA1_uc004ajg.1_Nonsense_Mutation_p.Q23*	NM_000700	NP_000691	P04083	ANXA1_HUMAN	annexin I	23					alpha-beta T cell differentiation|anti-apoptosis|cell surface receptor linked signaling pathway|cellular component movement|inflammatory response|keratinocyte differentiation|lipid metabolic process|peptide cross-linking|positive regulation of vesicle fusion	basolateral plasma membrane|cilium|cornified envelope|cytoplasm|extracellular region|nucleus	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity|protein binding, bridging|receptor binding|structural molecule activity			breast(1)|central_nervous_system(1)	2		all_epithelial(88;2.54e-11)		OV - Ovarian serous cystadenocarcinoma(323;2.82e-06)|GBM - Glioblastoma multiforme(74;0.0325)	Alclometasone(DB00240)|Amcinonide(DB00288)|Beclomethasone(DB00394)|Betamethasone(DB00443)|Clobetasol(DB01013)|Clocortolone(DB00838)|Desonide(DB01260)|Desoximetasone(DB00547)|Dexamethasone(DB01234)|Diflorasone(DB00223)|Flumethasone Pivalate(DB00663)|Halobetasol Propionate(DB00596)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mometasone(DB00764)|Prednicarbate(DB01130)|Prednisone(DB00635)|Rimexolone(DB00896)|Triamcinolone(DB00620)	TCATTCTTAGCAAACTGTGAA	0.373000													8	29					0	0	0.003080	0	0
GCNT1	2650	broad.mit.edu	37	9	79117864	79117864	+	Silent	SNP	G	A	A			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr9:79117864G>A	uc010mpf.2	+	3	908	c.567G>A	c.(565-567)TCG>TCA	p.S189S	GCNT1_uc010mpg.2_Silent_p.S189S|GCNT1_uc010mph.2_Silent_p.S189S|GCNT1_uc004akf.3_Silent_p.S189S|GCNT1_uc010mpi.2_Silent_p.S189S|GCNT1_uc004akh.3_Silent_p.S189S	NM_001490	NP_001481	Q02742	GCNT1_HUMAN	beta-1,3-galactosyl-O-glycosyl-glycoprotein	189	Lumenal (Potential).|Catalytic (By similarity).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity				0						TTTATGCATCGTGGAGCCGGG	0.458000													24	54					0	0	0.003330	0	0
FRMPD4	9758	broad.mit.edu	37	X	12736404	12736404	+	Silent	SNP	C	T	T			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chrX:12736404C>T	uc004cuz.1	+	16	3965	c.3459C>T	c.(3457-3459)GAC>GAT	p.D1153D	FRMPD4_uc011mij.1_Silent_p.D1145D	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1153					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						TCTTAACTGACGTGACCTGTG	0.552000													84	32					0	0	0.014410	0	0
POF1B	79983	broad.mit.edu	37	X	84600916	84600916	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chrX:84600916G>A	uc004eer.2	-	6	819	c.673C>T	c.(673-675)CAT>TAT	p.H225Y	POF1B_uc004ees.2_Missense_Mutation_p.H225Y	NM_024921	NP_079197	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	225							actin binding				0						TTTCCAATATGTGTAGAAATT	0.418000													6	70					0	0	0.001984	0	0
REN	5972	broad.mit.edu	37	1	204135375	204135377	+	In_Frame_Del	DEL	AGC	-	-	rs121917743		TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr1:204135375_204135377delAGC	uc001haq.2	-	1	89_91	c.45_47delGCT	c.(43-48)CTGCTC>CTC	p.15_16LL>L		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	15_16			L -> R (in HNFJ2; affects ER translocation and processing of nascent preprorenin, resulting in abolished prorenin and renin biosynthesis and secretion).		angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	GGAGCCCCAGAGCAGCAGCAGCA	0.581													9	1700	---	---	---	---					
IL32	9235	broad.mit.edu	37	16	3119304	3119305	+	Frame_Shift_Ins	INS	-	G	G	rs2981599		TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr16:3119304_3119305insG	uc002cto.2	+	6	864_865	c.653_654insG	c.(652-654)GACfs	p.D218fs	IL32_uc002ctk.2_Frame_Shift_Ins_p.D115fs|IL32_uc010uwp.1_Frame_Shift_Ins_p.D152fs|IL32_uc010btb.2_Frame_Shift_Ins_p.D162fs|IL32_uc002ctl.2_Frame_Shift_Ins_p.D172fs|IL32_uc002ctm.2_Frame_Shift_Ins_p.D172fs|IL32_uc002ctn.2_Frame_Shift_Ins_p.D172fs|IL32_uc002cts.3_Frame_Shift_Ins_p.D172fs|IL32_uc002ctp.2_Frame_Shift_Ins_p.D152fs|IL32_uc002ctq.2_Frame_Shift_Ins_p.D218fs|IL32_uc002ctr.2_Frame_Shift_Ins_p.D152fs|IL32_uc002ctt.2_Frame_Shift_Ins_p.D172fs|IL32_uc010uwr.1_Frame_Shift_Ins_p.D132fs|IL32_uc002ctu.2_Frame_Shift_Ins_p.D163fs	NM_004221	NP_004212	P24001	IL32_HUMAN	interleukin 32 isoform B	218					cell adhesion|defense response|immune response	extracellular space	cytokine activity			pancreas(1)	1						CCACGGGGGGACAAGGAGGAGC	0.574													18	196	---	---	---	---					
WDR62	284403	broad.mit.edu	37	19	36590446	36590447	+	In_Frame_Ins	INS	-	GAAGCC	GAAGCC	rs139749569	byFrequency	TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr19:36590446_36590447insGAAGCC	uc002odc.2	+	22	2757_2758	c.2666_2667insGAAGCC	c.(2665-2667)ATG>ATGAAGCCG	p.891_892insKP	WDR62_uc002odd.2_In_Frame_Ins_p.891_892insKP	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	891_892					cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TTTACCCCCATGAAGCCCGAGA	0.634													21	82	---	---	---	---					
NF2	4771	broad.mit.edu	37	22	30069292	30069292	+	Frame_Shift_Del	DEL	A	-	-			TCGA-DU-7292-01A-11D-2024-08	TCGA-DU-7292-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	8a5ba698-330f-45de-9f1f-aee1235775b7	4debfd4f-275c-41f6-a4f7-ed2917dc1a3f	g.chr22:30069292delA	uc003age.3	+	12	1600	c.1157delA	c.(1156-1158)GAAfs	p.E386fs	NF2_uc003afy.3_Frame_Shift_Del_p.E386fs|NF2_uc003afz.3_Frame_Shift_Del_p.E303fs|NF2_uc003agf.3_Frame_Shift_Del_p.E386fs|NF2_uc003agb.3_Frame_Shift_Del_p.E309fs|NF2_uc003agc.3_Frame_Shift_Del_p.E348fs|NF2_uc003agd.3_Intron|NF2_uc003agg.3_Frame_Shift_Del_p.E386fs|NF2_uc003aga.3_Frame_Shift_Del_p.E344fs|NF2_uc003agh.3_Frame_Shift_Del_p.E345fs|NF2_uc003agi.3_Frame_Shift_Del_p.E303fs|NF2_uc003agj.3_Intron|NF2_uc003agk.3_Frame_Shift_Del_p.E348fs|NF2_uc010gvp.2_Frame_Shift_Del_p.E50fs|NF2_uc011akq.1_Frame_Shift_Del_p.E12fs	NM_000268	NP_000259	P35240	MERL_HUMAN	neurofibromin 2 isoform 1	386	Glu-rich.				actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.L383fs*12(1)|p.M375fs*20(1)|p.?(1)		meninges(372)|soft_tissue(284)|central_nervous_system(20)|kidney(10)|pleura(9)|skin(7)|large_intestine(5)|breast(5)|urinary_tract(3)|thyroid(2)|endometrium(2)|ovary(2)|lung(2)|stomach(2)|bone(2)|pituitary(1)	728						CTGTTGGCTGAAAAGGCCCAG	0.587			D|Mis|N|F|S|O		meningioma|acoustic neuroma|renal 	meningioma|acoustic neuroma			Neurofibromatosis_type_2				2	4	---	---	---	---					
