Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PRAMEF1	65121	broad.mit.edu	37	1	12854207	12854207	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr1:12854207A>G	uc001auj.1	+	3	534	c.431A>G	c.(430-432)CAC>CGC	p.H144R		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	144											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ATGGGAGAGCACCAGCCCTTA	0.532000													9	168					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42048876	42048876	+	Silent	SNP	G	A	A			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr1:42048876G>A	uc001cgz.3	-	4	2806	c.1593C>T	c.(1591-1593)ACC>ACT	p.T531T	HIVEP3_uc001cha.3_Silent_p.T531T|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	531	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CAGGGGGGGCGGTACTGGGCG	0.607000													3	63					0	0	1	0	0
AKR1CL1	340811	broad.mit.edu	37	10	5203897	5203897	+	RNA	SNP	C	T	T			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr10:5203897C>T	uc009xhz.2	-	3		c.383G>A				NR_027916				Homo sapiens cDNA FLJ16347 fis, clone TESTI2036288, moderately similar to PROSTAGLANDIN-F SYNTHASE 1 (EC 1.1.1.188).												0						TTTCTAGGGCCGGGTGAACCA	0.388000													13	22					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15559198	15559198	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr10:15559198C>T	uc001ioc.1	-	30	3151	c.3151G>A	c.(3151-3153)GAC>AAC	p.D1051N	ITGA8_uc010qcb.1_Missense_Mutation_p.D1036N	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	1051	Cytoplasmic (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						TGTTCCCTGTCGGTCATGTCC	0.443000													15	30					0	0	1	0	0
Unknown	0	broad.mit.edu	37	10	30998301	30998301	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr10:30998301T>C	uc010qdx.1	+	8	1389	c.847T>C	c.(847-849)TTC>CTC	p.F283L						SubName: Full=cDNA FLJ59642, highly similar to Supervillin;																		AGCCACGGAGTTCGTGTACCC	0.582000													13	67					0	0	1	0	0
PGAM1	5223	broad.mit.edu	37	10	99186071	99186071	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr10:99186071G>T	uc001knh.2	+	1	45	c.7G>T	c.(7-9)GCC>TCC	p.A3S	uc001kng.1_5'Flank|PGAM1_uc009xvo.2_Missense_Mutation_p.A3S|PGAM1_uc010qov.1_5'Flank	NM_002629	NP_002620	P18669	PGAM1_HUMAN	phosphoglycerate mutase 1	3					gluconeogenesis|glycolysis|regulation of glycolysis|regulation of pentose-phosphate shunt|respiratory burst	cytosol	2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity|protein kinase binding				0		Colorectal(252;0.162)		Epithelial(162;8.36e-10)|all cancers(201;5.62e-08)		CGCCATGGCCGCCTACAAACT	0.706000													8	45					1.12685e-05	1.15772e-05	1	1	0
GALNTL4	374378	broad.mit.edu	37	11	11642953	11642953	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr11:11642953A>G	uc001mjo.2	-	1	609	c.188T>C	c.(187-189)ATT>ACT	p.I63T		NM_198516	NP_940918	Q6P9A2	GLTL4_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	63	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0				all cancers(16;3.67e-05)|Epithelial(150;0.000184)		CAGCCGCTCAATAATCTTCAG	0.622000													52	110					0	0	1	0	0
GIF	2694	broad.mit.edu	37	11	59611461	59611461	+	Silent	SNP	T	C	C			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr11:59611461T>C	uc001noi.2	-	2	195	c.147A>G	c.(145-147)TCA>TCG	p.S49S	GIF_uc010rkz.1_Silent_p.S49S	NM_005142	NP_005133	P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	49					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			ovary(1)|liver(1)	2						GGTAGGCTGATGAAGTCACCG	0.522000													14	51					0	0	1	0	0
BTG4	54766	broad.mit.edu	37	11	111365994	111365994	+	Missense_Mutation	SNP	G	A	A	rs140812937		TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr11:111365994G>A	uc001plj.2	-	5	741	c.556C>T	c.(556-558)CGC>TGC	p.R186C		NM_017589	NP_060059	Q9NY30	BTG4_HUMAN	B-cell translocation gene 4	186					cell cycle arrest|negative regulation of cell proliferation|neuron differentiation						0		all_cancers(61;3.78e-13)|all_epithelial(67;5.29e-08)|Melanoma(852;3.15e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0204)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;1.22e-06)|BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|all cancers(92;2.18e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0509)		TTCTTTTTGCGGGGGATTTGT	0.448000													25	50					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41333261	41333261	+	Silent	SNP	G	A	A			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr12:41333261G>A	uc001rmm.1	+	12	1466	c.1353G>A	c.(1351-1353)GGG>GGA	p.G451G	CNTN1_uc009zjy.1_Silent_p.G451G|CNTN1_uc001rmn.1_Silent_p.G440G|CNTN1_uc001rmo.2_Silent_p.G451G	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	451	Ig-like C2-type 5.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GGAGTAAAGGGACAGAGTGGC	0.373000													9	25					0	0	1	0	0
MPHOSPH8	54737	broad.mit.edu	37	13	20221185	20221185	+	Silent	SNP	C	T	T			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr13:20221185C>T	uc001umh.2	+	3	981	c.972C>T	c.(970-972)ACC>ACT	p.T324T	MPHOSPH8_uc001umf.1_Silent_p.T324T|MPHOSPH8_uc001umg.2_Silent_p.T324T|MPHOSPH8_uc001umi.2_Silent_p.T21T	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	324					cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		AGGAGGATACCGATGTCAGAG	0.498000													13	40					0	0	1	0	0
LATS2	26524	broad.mit.edu	37	13	21562426	21562426	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr13:21562426C>A	uc009zzs.2	-	4	1858	c.1493G>T	c.(1492-1494)GGC>GTC	p.G498V	LATS2_uc001unr.3_Missense_Mutation_p.G498V	NM_014572	NP_055387	Q9NRM7	LATS2_HUMAN	LATS, large tumor suppressor, homolog 2	498					cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(3)|ovary(2)|breast(1)|pancreas(1)	10		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		CGGGAAGGCGCCTGCGCCGCC	0.567000													6	7					0.000157383	0.000157383	1	1	0
UPF3A	65110	broad.mit.edu	37	13	115047559	115047559	+	Silent	SNP	C	T	T			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr13:115047559C>T	uc001vup.2	+	2	308	c.271C>T	c.(271-273)CTG>TTG	p.L91L	UPF3A_uc010tkn.1_Silent_p.L91L|UPF3A_uc001vuq.2_Silent_p.L91L|UPF3A_uc001vus.2_RNA|UPF3A_uc001vur.2_RNA	NM_023011	NP_075387	Q9H1J1	REN3A_HUMAN	UPF3 regulator of nonsense transcripts homolog A	91	Required for interaction with UPF2.				mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			skin(1)	1	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)		GCTGCGCCCGCTGCCAGCACA	0.731000													3	11					0	0	1	0	0
LOC646214	646214	broad.mit.edu	37	15	21936464	21936464	+	RNA	SNP	C	T	T	rs8025772	by1000genomes	TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr15:21936464C>T	uc010tzj.1	-	1		c.4276G>A				NR_027053				Homo sapiens mRNA for p21-activated kinase 2 variant protein.												0						GTTATGCAGACCATTTCTTTA	0.328000													4	10					0	0	1	0	0
RRN3P3	100131998	broad.mit.edu	37	16	22441236	22441236	+	RNA	SNP	G	A	A	rs114681793	by1000genomes	TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr16:22441236G>A	uc002dkp.2	-	5		c.1170C>T			RRN3P3_uc010vbu.1_RNA	NR_027460				Homo sapiens cDNA FLJ31180 fis, clone KIDNE2000266.												0						TGTTCCTCTCGATGATGGTGT	0.507000													6	75					0	0	1	0	0
Unknown	0	broad.mit.edu	37	16	28354418	28354418	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr16:28354418C>T	uc010vcq.1	-	7	787	c.734G>A	c.(733-735)CGC>CAC	p.R245H	uc010vcr.1_Missense_Mutation_p.R263H					SubName: Full=LOC728741 protein;																		AGGTGGCTGGCGGCCCATCCT	0.527000													5	31					0	0	1	0	0
CCDC113	29070	broad.mit.edu	37	16	58287907	58287907	+	Silent	SNP	A	G	G			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr16:58287907A>G	uc002ene.2	+	3	313	c.234A>G	c.(232-234)CGA>CGG	p.R78R	CCDC113_uc010vid.1_Intron	NM_014157	NP_054876	Q9H0I3	CC113_HUMAN	coiled-coil domain containing 113 isoform 1	78						protein complex					0						TGCAGTTTCGAGGCAGGCGTA	0.498000													41	72					0	0	1	0	0
ARRB2	409	broad.mit.edu	37	17	4623596	4623596	+	Splice_Site	SNP	T	G	G			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr17:4623596T>G	uc002fyj.2	+	12	1229	c.1001_splice	c.e12+2	p.G334_splice	ARRB2_uc002fyk.2_Splice_Site_p.G319_splice|ARRB2_uc002fyl.2_Splice_Site_p.G334_splice|ARRB2_uc010vsg.1_Splice_Site_p.G355_splice|ARRB2_uc002fym.2_Splice_Site_p.G319_splice|ARRB2_uc002fyn.2_Splice_Site_p.G142_splice|ARRB2_uc010ckq.2_Splice_Site_p.G142_splice|ARRB2_uc002fyo.2_Splice_Site_p.G142_splice	NM_004313	NP_004304	P32121	ARRB2_HUMAN	arrestin, beta 2 isoform 1						cell chemotaxis|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|G-protein coupled receptor internalization|negative regulation of natural killer cell mediated cytotoxicity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway	coated pit|cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	angiotensin receptor binding|ubiquitin protein ligase binding				0						TCGAGGCGGGTGAGTGTCATG	0.607000													8	46					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577094	7577094	+	Missense_Mutation	SNP	G	A	A	rs28934574		TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr17:7577094G>A	uc002gim.2	-	8	1038	c.844C>T	c.(844-846)CGG>TGG	p.R282W	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R282W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R150W|TP53_uc010cng.1_Missense_Mutation_p.R150W|TP53_uc002gii.1_Missense_Mutation_p.R150W|TP53_uc010cnh.1_Missense_Mutation_p.R282W|TP53_uc010cni.1_Missense_Mutation_p.R282W|TP53_uc002gij.2_Missense_Mutation_p.R282W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	282	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|R -> Q (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(367)|p.R282G(27)|p.R282Q(20)|p.R282P(14)|p.R282R(8)|p.0?(7)|p.R282L(3)|p.D281fs*63(2)|p.?(2)|p.R282fs*24(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.R280fs*62(1)|p.R282_E287delRRTEEE(1)|p.G279fs*59(1)|p.S269fs*21(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.R282H(1)|p.R283_T284>T(1)|p.V272_K292del21(1)|p.R282fs*63(1)|p.C275fs*20(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGTGCGCCGGTCTCTCCCA	0.557000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			20	44					0	0	1	0	0
UBB	7314	broad.mit.edu	37	17	16285491	16285491	+	Silent	SNP	C	T	T	rs16962973		TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr17:16285491C>T	uc002gpx.2	+	2	408	c.270C>T	c.(268-270)ACC>ACT	p.T90T	UBB_uc010vwe.1_Intron	NM_018955	NP_061828	P0CG47	UBB_HUMAN	ubiquitin B precursor	90	Ubiquitin-like 2.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		AGACCATCACCCTGGAAGTGG	0.552000													4	109					0	0	1	0	0
UBB	7314	broad.mit.edu	37	17	16285497	16285497	+	Silent	SNP	A	G	G			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr17:16285497A>G	uc002gpx.2	+	2	414	c.276A>G	c.(274-276)GAA>GAG	p.E92E	UBB_uc010vwe.1_Intron	NM_018955	NP_061828	P0CG47	UBB_HUMAN	ubiquitin B precursor	92	Ubiquitin-like 2.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		TCACCCTGGAAGTGGAGCCCA	0.557000													4	108					0	0	1	0	0
GFAP	2670	broad.mit.edu	37	17	42991175	42991175	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr17:42991175G>T	uc002ihq.2	-	3	599	c.539C>A	c.(538-540)ACC>AAC	p.T180N	GFAP_uc002ihr.2_Missense_Mutation_p.T180N|GFAP_uc010wjg.1_RNA	NM_002055	NP_002046	P14136	GFAP_HUMAN	glial fibrillary acidic protein isoform 1	180	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			ovary(1)|pancreas(1)	2		Prostate(33;0.0959)				ACGGGCCAGGGTGGCTTCATC	0.622000													66	96					7.577e-32	8.11821e-32	1	1	0
ELANE	1991	broad.mit.edu	37	19	852925	852925	+	Silent	SNP	C	T	T			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr19:852925C>T	uc002lqb.2	+	2	155	c.117C>T	c.(115-117)CAC>CAT	p.H39H		NM_001972	NP_001963	P08246	ELNE_HUMAN	neutrophil elastase preproprotein	39	Peptidase S1.				cellular calcium ion homeostasis|negative regulation of chemokine biosynthetic process|negative regulation of chemotaxis|negative regulation of inflammatory response|negative regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of MAP kinase activity|positive regulation of smooth muscle cell proliferation|protein catabolic process|proteolysis|response to UV	cell surface|extracellular region|stored secretory granule	bacterial cell surface binding|cytokine binding|heparin binding			pancreas(1)	1					Alpha-1-proteinase inhibitor(DB00058)|Filgrastim(DB00099)|Pegfilgrastim(DB00019)	CGCGGCCCCACGCGTGGCCCT	0.721000									Kostmann_syndrome				6	22					0	0	1	0	0
PKN1	5585	broad.mit.edu	37	19	14557260	14557260	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr19:14557260C>A	uc002myp.2	+	4	665	c.497C>A	c.(496-498)GCC>GAC	p.A166D	PKN1_uc002myq.2_Missense_Mutation_p.A172D	NM_002741	NP_002732	Q16512	PKN1_HUMAN	protein kinase N1 isoform 2	166	REM 2.				activation of JUN kinase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	endosome|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|GTP-Rho binding|histone binding|histone deacetylase binding|histone kinase activity (H3-T11 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|Rac GTPase binding			ovary(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8						CTGCTGACAGCCCAGCAGATG	0.612000													6	126					3.59834e-05	3.64696e-05	1	1	0
LRP3	4037	broad.mit.edu	37	19	33696671	33696671	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr19:33696671G>A	uc010edh.2	+	5	1088	c.995G>A	c.(994-996)CGG>CAG	p.R332Q	LRP3_uc010xrp.1_Missense_Mutation_p.R206Q|LRP3_uc002nuk.3_Missense_Mutation_p.R206Q	NM_002333	NP_002324	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein	332	Extracellular (Potential).|CUB 2.				receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			pancreas(2)|ovary(1)	3	Esophageal squamous(110;0.137)					AGCAACCACCGGCCCGTGAGC	0.706000													9	1					0	0	1	0	0
PRX	57716	broad.mit.edu	37	19	40899883	40899883	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr19:40899883G>A	uc002onr.2	-	7	4645	c.4376C>T	c.(4375-4377)GCG>GTG	p.A1459V	PRX_uc002onq.2_Missense_Mutation_p.A1320V|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	1459					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TCAGACAGCCGCAGCCTGAGC	0.617000													3	51					0	0	1	0	0
MIR520H	574493	broad.mit.edu	37	19	54245794	54245794	+	RNA	SNP	A	G	G			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr19:54245794A>G	hsa-mir-520h|MI0003175	+			c.29A>G			uc010yeb.1_5'Flank																	0						TAGAGGAAGCACTTTCTGTTT	0.388000													20	38					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55105741	55105741	+	Missense_Mutation	SNP	T	A	A			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr19:55105741T>A	uc002qgh.1	+	2	214	c.32T>A	c.(31-33)CTC>CAC	p.L11H	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Missense_Mutation_p.L11H	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	11					cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		CTGATCTGTCTCAGTGAGATT	0.587000													51	62					0	0	1	0	0
OTOF	9381	broad.mit.edu	37	2	26686908	26686908	+	Missense_Mutation	SNP	C	T	T	rs143889717		TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr2:26686908C>T	uc002rhk.2	-	40	5154	c.5027G>A	c.(5026-5028)CGC>CAC	p.R1676H	OTOF_uc010yla.1_Missense_Mutation_p.R406H|OTOF_uc002rhh.2_Missense_Mutation_p.R909H|OTOF_uc002rhi.2_Missense_Mutation_p.R986H|OTOF_uc002rhj.2_Missense_Mutation_p.R909H	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	1676	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCAGCCTGCGCGGGGGATGTC	0.667000													63	148					0	0	1	0	0
ANKRD20B	729171	broad.mit.edu	37	2	95522786	95522786	+	RNA	SNP	T	C	C			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr2:95522786T>C	uc010fhp.2	-	1		c.35A>G				NR_003366				Homo sapiens ankyrin repeat domain 20B (ANKRD20B), non-coding RNA.												0						CGGCGTCGCCTTTGACAGCTG	0.687000													3	75					0	0	1	0	0
TMEM131	23505	broad.mit.edu	37	2	98504555	98504555	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr2:98504555G>A	uc002syh.3	-	4	548	c.319C>T	c.(319-321)CCC>TCC	p.P107S	TMEM131_uc010yvg.1_RNA	NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	107						integral to membrane				ovary(4)|central_nervous_system(2)	6						AATCGTATGGGCCTGCAATTC	0.338000													8	24					0	0	1	0	0
RIF1	55183	broad.mit.edu	37	2	152319418	152319418	+	Silent	SNP	C	T	T			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr2:152319418C>T	uc002txm.2	+	30	3514	c.3384C>T	c.(3382-3384)GAC>GAT	p.D1128D	RIF1_uc002txl.2_Silent_p.D1128D|RIF1_uc002txn.2_Silent_p.D1128D|RIF1_uc002txo.2_Silent_p.D1128D|RIF1_uc002txp.2_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	1128					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		TGGACAGTGACATTGTCATTC	0.393000													16	34					0	0	1	0	0
GALNT13	114805	broad.mit.edu	37	2	155306962	155306962	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr2:155306962G>C	uc002tyr.3	+	13	2137	c.1570G>C	c.(1570-1572)GAT>CAT	p.D524H	GALNT13_uc002tyt.3_3'UTR|GALNT13_uc010fod.2_3'UTR|uc002tyu.1_Intron	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	524	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						CCAATGTCTCGATGAACCTTC	0.438000													30	60					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166170182	166170182	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr2:166170182G>A	uc002udc.2	+	9	1377	c.1087G>A	c.(1087-1089)GGC>AGC	p.G363S	SCN2A_uc002udd.2_Missense_Mutation_p.G363S|SCN2A_uc002ude.2_Missense_Mutation_p.G363S	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	363	I.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	CCCCAACTATGGCTACACGAG	0.433000													29	60					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								17	68					0	0	1	0	0
DNAJC28	54943	broad.mit.edu	37	21	34860571	34860571	+	Missense_Mutation	SNP	A	T	T			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr21:34860571A>T	uc002yrv.2	-	2	1579	c.1130T>A	c.(1129-1131)ATG>AAG	p.M377K	DNAJC28_uc002yrw.2_Missense_Mutation_p.M377K	NM_017833	NP_060303	Q9NX36	DJC28_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 28	377				LIVPILTRQKVHFDAQKEIVRAQKIYETLIKTKEVTDRNPN NLDQGEGEKTPEIKKGFLNWMNLWKFIKIRSF -> CSHPD QAKSPF (in Ref. 2; BAA91185).			heat shock protein binding				0						CCACAGATTCATCCAGTTTAA	0.299000													8	20					0	0	1	0	0
COL6A1	1291	broad.mit.edu	37	21	47409674	47409674	+	Silent	SNP	A	G	G			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr21:47409674A>G	uc002zhu.1	+	11	1014	c.912A>G	c.(910-912)AAA>AAG	p.K304K		NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	304	Triple-helical region.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	AGGGAGAAAAAGGGAGCCGTG	0.637000													3	111					0	0	1	0	0
HDAC10	83933	broad.mit.edu	37	22	50689416	50689416	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr22:50689416G>T	uc003bkg.2	-	1	419	c.46C>A	c.(46-48)CTG>ATG	p.L16M	HDAC10_uc003bke.2_Intron|HDAC10_uc003bkf.2_Intron|HDAC10_uc010hav.2_Missense_Mutation_p.L16M|HDAC10_uc003bkh.2_Translation_Start_Site|HDAC10_uc003bki.2_Missense_Mutation_p.L16M|HDAC10_uc003bkj.2_RNA|HDAC10_uc003bkk.1_5'Flank|MAPK12_uc003bkn.2_3'UTR|MAPK12_uc003bko.2_3'UTR|MAPK12_uc003bkl.1_3'UTR	NM_032019	NP_114408	Q969S8	HDA10_HUMAN	histone deacetylase 10 isoform 1	16	Histone deacetylase.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TCCCAGAGCAGCCGGGTGGCC	0.667000													27	41					7.01153e-11	7.40655e-11	1	1	0
EDEM1	9695	broad.mit.edu	37	3	5248941	5248941	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr3:5248941T>C	uc003bqi.2	+	7	1453	c.1321T>C	c.(1321-1323)TTT>CTT	p.F441L	EDEM1_uc011asz.1_Missense_Mutation_p.F219L|EDEM1_uc003bqh.2_Missense_Mutation_p.F441L	NM_014674	NP_055489	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like	441	Lumenal (Potential).				ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			ovary(2)|breast(1)	3				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		TCTGCAGGCCTTTTTCCCTGG	0.463000													3	116					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7620355	7620355	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr3:7620355T>C	uc003bqm.2	+	8	2036	c.1762T>C	c.(1762-1764)TCC>CCC	p.S588P	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.S588P|GRM7_uc003bql.2_Missense_Mutation_p.S588P|GRM7_uc003bqn.1_Missense_Mutation_p.S171P|GRM7_uc010hch.1_Missense_Mutation_p.S99P	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	588	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	GGAGTGGCACTCCCCCTGGGC	0.512000													3	142					0	0	1	0	0
LOC729375	729375	broad.mit.edu	37	3	129817316	129817316	+	RNA	SNP	C	T	T	rs61073628	by1000genomes	TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr3:129817316C>T	uc003ene.2	-	3		c.1195G>A			LOC729375_uc011ble.1_RNA					Homo sapiens cDNA FLJ42457 fis, clone BRACE2018700.												0						TGGCCAGAAGCTGAAATGACG	0.562000													2	3					0	0	1	0	0
ANKRD17	26057	broad.mit.edu	37	4	74012998	74012998	+	Silent	SNP	T	C	C			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr4:74012998T>C	uc003hgp.2	-	9	1836	c.1719A>G	c.(1717-1719)CAA>CAG	p.Q573Q	ANKRD17_uc003hgo.2_Silent_p.Q460Q|ANKRD17_uc003hgq.2_Silent_p.Q573Q|ANKRD17_uc003hgr.2_Silent_p.Q573Q|ANKRD17_uc011cbd.1_Intron	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	573	ANK 11.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AATGACCCTCTTGAGCAGCTT	0.398000													43	75					0	0	1	0	0
ADH1C	126	broad.mit.edu	37	4	100263953	100263953	+	Missense_Mutation	SNP	A	G	G	rs78836241		TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr4:100263953A>G	uc003huu.2	-	8	912	c.827T>C	c.(826-828)ATG>ACG	p.M276T		NM_000669	NP_000660	P00326	ADH1G_HUMAN	class I alcohol dehydrogenase, gamma subunit	276					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	GGATCATACCATGGTGTCAAG	0.413000									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				81	176					0	0	1	0	0
TBCK	93627	broad.mit.edu	37	4	107229997	107229997	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr4:107229997G>A	uc010ilv.2	-	2	486	c.121C>T	c.(121-123)CGC>TGC	p.R41C	TBCK_uc003hye.2_Missense_Mutation_p.R41C|TBCK_uc003hyc.2_Missense_Mutation_p.R41C|TBCK_uc003hyd.2_5'UTR|TBCK_uc003hyf.2_Missense_Mutation_p.R41C	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	41	Protein kinase.					intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						ATTTGAAAGCGCCCTAAAATT	0.413000													24	63					0	0	1	0	0
ERAP1	51752	broad.mit.edu	37	5	96124295	96124295	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr5:96124295T>C	uc003kmm.2	-	11	1965	c.1618A>G	c.(1618-1620)AGG>GGG	p.R540G	ERAP1_uc003kml.2_Missense_Mutation_p.R540G|ERAP1_uc010jbm.1_Missense_Mutation_p.R352G|ERAP1_uc003kmn.2_Missense_Mutation_p.R540G	NM_001040458	NP_001035548	Q9NZ08	ERAP1_HUMAN	type 1 tumor necrosis factor receptor shedding	540	Lumenal (Potential).				angiogenesis|antigen processing and presentation of endogenous peptide antigen via MHC class I|fat cell differentiation|membrane protein ectodomain proteolysis|regulation of blood pressure|regulation of innate immune response|response to bacterium	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|integral to membrane	aminopeptidase activity|interleukin-1, Type II receptor binding|interleukin-6 receptor binding|metalloexopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		all_cancers(142;1.75e-06)|all_epithelial(76;3.08e-09)|all_lung(232;0.000435)|Lung NSC(167;0.000601)|Ovarian(225;0.024)|Colorectal(57;0.0432)|Breast(839;0.244)		all cancers(79;7.26e-15)|COAD - Colon adenocarcinoma(37;0.071)		TGTACATTCCTCCCCCTCACT	0.488000													3	89					0	0	1	0	0
HIST1H4E	8367	broad.mit.edu	37	6	26204972	26204972	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr6:26204972G>C	uc003ngy.2	+	1	100	c.100G>C	c.(100-102)GCC>CCC	p.A34P		NM_003545	NP_003536	P62805	H4_HUMAN	histone cluster 1, H4e	34					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1		all_hematologic(11;0.196)				TACCAAGCCTGCCATCCGGCG	0.577000													4	100					0	0	1	0	0
FRK	2444	broad.mit.edu	37	6	116381344	116381344	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr6:116381344C>T	uc003pwi.1	-	1	578	c.131G>A	c.(130-132)GGC>GAC	p.G44D		NM_002031	NP_002022	P42685	FRK_HUMAN	fyn-related kinase	44	SH3.				negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|lung(3)	6		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		AAAGTAGTGGCCATGCCTCTG	0.517000													6	157					0	0	1	0	0
KIF25	3834	broad.mit.edu	37	6	168440828	168440828	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr6:168440828C>T	uc003qwk.1	+	6	840	c.578C>T	c.(577-579)GCG>GTG	p.A193V	KIF25_uc003qwl.1_Missense_Mutation_p.A193V	NM_030615	NP_085118	Q9UIL4	KIF25_HUMAN	kinesin family member 25 isoform 1	193	Kinesin-motor.				microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(1)|pancreas(1)	2		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		CTGGTGCACGCGGATTCCTCC	0.572000													16	47					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47840379	47840379	+	Silent	SNP	G	A	A	rs138774842		TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr7:47840379G>A	uc003tny.1	-	54	8061	c.8061C>T	c.(8059-8061)CCC>CCT	p.P2687P	C7orf69_uc003tnz.3_Intron|C7orf69_uc003toa.1_Intron	NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2687	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						ACAGCAGCCCGGGGAAGGCGT	0.567000													42	107					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138603027	138603027	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr7:138603027C>T	uc011kql.1	-	2	1394	c.1345G>A	c.(1345-1347)GAG>AAG	p.E449K	KIAA1549_uc003vuk.3_Missense_Mutation_p.E399K|KIAA1549_uc011kqj.1_Missense_Mutation_p.E449K	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	449						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						CACAGAGTCTCGGCACCATCC	0.517000			O	BRAF	pilocytic astrocytoma								10	102					0	0	1	0	0
ACTR3C	653857	broad.mit.edu	37	7	149990490	149990490	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr7:149990490C>T	uc003wgu.1	-	3	254	c.64G>A	c.(64-66)GCA>ACA	p.A22T		NM_001040135	NP_001035225	Q9C0K3	ARP3C_HUMAN	actin-related protein 3-beta isoform 2	22					regulation of actin filament polymerization	cytoskeleton	actin binding|ATP binding				0						GTCCAAGATGCCGCCAAGGCC	0.507000													3	20					0	0	1	0	0
CHRNA2	1135	broad.mit.edu	37	8	27321507	27321507	+	Silent	SNP	T	G	G			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr8:27321507T>G	uc010lur.2	-	6	1062	c.453A>C	c.(451-453)GCA>GCC	p.A151A	CHRNA2_uc011lal.1_Silent_p.A136A|CHRNA2_uc010lus.2_Intron	NM_000742	NP_000733	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha	151	Extracellular.					cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(1)	1		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine(DB01336)|Metocurine Iodide(DB00416)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	ACTCCCCATCTGCACTGAGAA	0.622000													7	30					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110487479	110487479	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr8:110487479C>T	uc003yne.2	+	51	8842	c.8738C>T	c.(8737-8739)TCG>TTG	p.S2913L		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2913	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCATATACATCGACATTCTAT	0.338000										HNSCC(38;0.096)			8	13					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94486807	94486807	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr9:94486807G>A	uc004arj.1	-	9	2168	c.1969C>T	c.(1969-1971)CGC>TGC	p.R657C	ROR2_uc004ari.1_Missense_Mutation_p.R517C	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	657	Cytoplasmic (Potential).|Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						GCCATCCAGCGGATAGGCAGC	0.572000													3	40					0	0	1	0	0
CDC14B	8555	broad.mit.edu	37	9	99296274	99296274	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr9:99296274G>A	uc004awj.2	-	9	1333	c.881C>T	c.(880-882)GCC>GTC	p.A294V	CDC14B_uc004awk.2_Missense_Mutation_p.A294V|CDC14B_uc004awl.2_RNA|CDC14B_uc004awi.2_Missense_Mutation_p.A257V	NM_033331	NP_201588	O60729	CC14B_HUMAN	CDC14 homolog B isoform 2	294	B.				activation of anaphase-promoting complex activity|DNA repair|G2/M transition DNA damage checkpoint	nucleolus|nucleoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)				TTTGACAATGGCATCAGTAGG	0.423000													8	8					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140953608	140953608	+	Missense_Mutation	SNP	A	T	T			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr9:140953608A>T	uc004cog.2	+	30	4696	c.4551A>T	c.(4549-4551)GAA>GAT	p.E1517D	CACNA1B_uc011mfd.1_Missense_Mutation_p.E1047D|CACNA1B_uc004coi.2_Missense_Mutation_p.E731D	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	1517	Helical; Name=S2 of repeat IV; (Potential).|IV.				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TCTCCATGGAATGCGTGCTGA	0.507000													4	43					0	0	1	0	0
ARSF	416	broad.mit.edu	37	X	3021883	3021883	+	Missense_Mutation	SNP	C	T	T	rs141853880	byFrequency	TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chrX:3021883C>T	uc004cre.1	+	9	1404	c.1183C>T	c.(1183-1185)CGG>TGG	p.R395W	ARSF_uc004crf.1_Missense_Mutation_p.R395W	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	395						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ACCAGCTGGACGGTTGATTAA	0.478000													36	80					0	0	1	0	0
WWC3	55841	broad.mit.edu	37	X	10085535	10085535	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chrX:10085535C>T	uc004csx.3	+	11	1634	c.1436C>T	c.(1435-1437)TCG>TTG	p.S479L	WWC3_uc010nds.2_Missense_Mutation_p.S143L|WWC3_uc010ndt.2_RNA	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	479										ovary(4)	4						TCACGGGACTCGCCGCTGGCG	0.706000													7	16					0	0	1	0	0
RPS6KA3	6197	broad.mit.edu	37	X	20205954	20205954	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chrX:20205954C>A	uc004czu.2	-	9	766	c.766G>T	c.(766-768)GTG>TTG	p.V256L	RPS6KA3_uc011mjk.1_Missense_Mutation_p.V227L|RPS6KA3_uc004czv.2_Missense_Mutation_p.V244L|RPS6KA3_uc011mjl.1_Missense_Mutation_p.V228L|RPS6KA3_uc011mjm.1_Missense_Mutation_p.V228L	NM_004586	NP_004577	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	256	Protein kinase 1.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(4)|stomach(1)|ovary(1)|lung(1)|breast(1)	8						ACCATTAACACACCAAAAGAC	0.388000													68	189					1.10345e-40	1.19941e-40	1	1	0
ZNF630	57232	broad.mit.edu	37	X	47918328	47918328	+	Silent	SNP	A	C	C			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chrX:47918328A>C	uc004div.3	-	5	1755	c.1503T>G	c.(1501-1503)CCT>CCG	p.P501P	ZNF630_uc010nhz.1_Intron|ZNF630_uc004diw.2_Silent_p.P377P	NM_001037735	NP_001032824	Q2M218	ZN630_HUMAN	zinc finger protein 630	501	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|lung(1)	2						GTATGATAAGAGGTGATTTCT	0.413000													32	42					0	0	1	0	0
TFE3	7030	broad.mit.edu	37	X	48887870	48887870	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chrX:48887870G>T	uc004dmb.3	-	10	1765	c.1527C>A	c.(1525-1527)CAC>CAA	p.H509Q	TFE3_uc004dmc.3_Missense_Mutation_p.H404Q	NM_006521	NP_006512	P19532	TFE3_HUMAN	transcription factor E3	509					humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		ASPSCR1/TFE3(161)|PRCC/TFE3(25)|SFPQ/TFE3(6)|NONO/TFE3(2)|CLTC/TFE3(2)	soft_tissue(120)|kidney(76)|central_nervous_system(1)	197						GGTCCCCCAGGTGGTCGCTGG	0.672000			T	SFPQ|ASPSCR1|PRCC|NONO|CLTC	papillary renal|alveolar soft part sarcoma|renal								16	127					8.10497e-08	8.44268e-08	1	1	0
MID2	11043	broad.mit.edu	37	X	107084173	107084173	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chrX:107084173T>C	uc004enl.2	+	2	851	c.278T>C	c.(277-279)CTC>CCC	p.L93P	MID2_uc004enk.2_Missense_Mutation_p.L93P	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	93						centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						CTGGATGGCCTCAAGAGGAAT	0.527000													3	113					0	0	1	0	0
IRS4	8471	broad.mit.edu	37	X	107978402	107978402	+	Silent	SNP	G	A	A			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chrX:107978402G>A	uc004eoc.2	-	1	1206	c.1173C>T	c.(1171-1173)GAC>GAT	p.D391D		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	391						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						AAAGCATCTCGTCTTCCCCGT	0.652000													42	86					0	0	1	0	0
HS6ST2	90161	broad.mit.edu	37	X	132091353	132091353	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chrX:132091353C>T	uc011mve.1	-	3	846	c.430G>A	c.(430-432)GTC>ATC	p.V144I	HS6ST2_uc011mvb.1_5'UTR|HS6ST2_uc011mvc.1_5'UTR|HS6ST2_uc011mvd.1_Missense_Mutation_p.V144I	NM_147175	NP_671704	Q96MM7	H6ST2_HUMAN	heparan sulfate 6-O-sulfotransferase 2 isoform	144	Lumenal (Potential).					integral to membrane	sulfotransferase activity				0	Acute lymphoblastic leukemia(192;0.000127)					ATGTTCCCGACGCTGGGGGAA	0.627000													10	46					0	0	1	0	0
GPR50	9248	broad.mit.edu	37	X	150349612	150349612	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chrX:150349612C>A	uc010ntg.1	+	2	1692	c.1557C>A	c.(1555-1557)GAC>GAA	p.D519E		NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	519	Cytoplasmic (Potential).|Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CCACTGCTGACTATCCCAAGC	0.617000													76	180					1.19347e-43	1.31633e-43	1	1	0
ATP2B3	492	broad.mit.edu	37	X	152827614	152827614	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chrX:152827614G>A	uc004fht.1	+	18	3199	c.3073G>A	c.(3073-3075)GGG>AGG	p.G1025R	ATP2B3_uc004fhs.1_Missense_Mutation_p.G1025R|ATP2B3_uc010nuf.1_Missense_Mutation_p.G48R|ATP2B3_uc004fhu.1_5'UTR	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	1025	Extracellular (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCAGTTTGGCGGGAAGCCCTT	0.612000													6	395					0	0	1	0	0
RLF	6018	broad.mit.edu	37	1	40701977	40701978	+	Frame_Shift_Del	DEL	AA	-	-			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr1:40701977_40701978delAA	uc001cfc.3	+	8	1634_1635	c.1603_1604delAA	c.(1603-1605)AAAfs	p.K535fs	RLF_uc001cfd.3_Frame_Shift_Del_p.K226fs	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	535					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			GCATAAGGAGAAAAGAGACAAA	0.356													29	31	---	---	---	---					
FUBP1	8880	broad.mit.edu	37	1	78433848	78433851	+	Splice_Site	DEL	CAGT	-	-			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr1:78433848_78433851delCAGT	uc001dii.2	-	3	339	c.250_splice	c.e3+1	p.S84_splice	FUBP1_uc001dih.3_Splice_Site|FUBP1_uc010orm.1_Splice_Site_p.S105_splice	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein						transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding	p.?(1)		central_nervous_system(2)|lung(1)	3						GGAATACTTACAGTCATTTTGAGG	0.319													8	14	---	---	---	---					
INA	9118	broad.mit.edu	37	10	105048271	105048273	+	In_Frame_Del	DEL	GAG	-	-			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr10:105048271_105048273delGAG	uc001kws.2	+	3	1394_1396	c.1345_1347delGAG	c.(1345-1347)GAGdel	p.E454del		NM_032727	NP_116116	Q16352	AINX_HUMAN	internexin neuronal intermediate filament	454	Tail.|Poly-Glu.				cell differentiation|nervous system development	neurofilament	structural constituent of cytoskeleton			ovary(1)|breast(1)	2				Epithelial(162;3.45e-09)|all cancers(201;9.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		ACTTAAGAAAGAGGAGGAGGAGG	0.458													8	134	---	---	---	---					
RAD9A	5883	broad.mit.edu	37	11	67163284	67163286	+	In_Frame_Del	DEL	GAG	-	-			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr11:67163284_67163286delGAG	uc001okr.2	+	6	640_642	c.547_549delGAG	c.(547-549)GAGdel	p.E185del	RAD9A_uc001oks.2_In_Frame_Del_p.E42del	NM_004584	NP_004575	Q99638	RAD9A_HUMAN	RAD9 homolog	185					DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint	nucleoplasm	3'-5' exonuclease activity|exodeoxyribonuclease III activity|histone deacetylase binding|protein kinase binding|SH3 domain binding				0			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			CAGCTACCACGAGGAGGAGGCAG	0.660								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					18	54	---	---	---	---					
PCNX	22990	broad.mit.edu	37	14	71443705	71443707	+	In_Frame_Del	DEL	CTT	-	-	rs147408993	byFrequency	TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr14:71443705_71443707delCTT	uc001xmo.2	+	6	1097_1099	c.651_653delCTT	c.(649-654)TCCTTC>TCC	p.F218del	PCNX_uc001xmn.3_In_Frame_Del_p.F218del|PCNX_uc010are.1_In_Frame_Del_p.F218del	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	218						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		CCAATGACTCCTTCATCTCTATT	0.414													7	113	---	---	---	---					
TTBK2	146057	broad.mit.edu	37	15	43045062	43045066	+	Frame_Shift_Del	DEL	ACTTA	-	-			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr15:43045062_43045066delACTTA	uc001zqo.2	-	14	2817_2821	c.2378_2382delTAAGT	c.(2377-2382)TTAAGTfs	p.L793fs	TTBK2_uc010bcy.2_Frame_Shift_Del_p.L724fs	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	793_794					cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		GCTGCCCTCTACTTAACTTCTCATC	0.400													27	85	---	---	---	---					
IREB2	3658	broad.mit.edu	37	15	78764190	78764192	+	In_Frame_Del	DEL	CCT	-	-			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr15:78764190_78764192delCCT	uc002bdr.2	+	7	969_971	c.807_809delCCT	c.(805-810)GACCTC>GAC	p.L271del	IREB2_uc010unb.1_In_Frame_Del_p.L21del|IREB2_uc002bdq.2_In_Frame_Del_p.L271del	NM_004136	NP_004127	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	271							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		AAGAAAAAGACCTCCTCTTCCCA	0.399													20	54	---	---	---	---					
ACADVL	37	broad.mit.edu	37	17	7125570	7125572	+	In_Frame_Del	DEL	AGG	-	-			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr17:7125570_7125572delAGG	uc002gev.2	+	9	978_980	c.827_829delAGG	c.(826-831)AAGGAG>AAG	p.E277del	DLG4_uc002get.3_5'Flank|DLG4_uc010vto.1_5'Flank|ACADVL_uc010vtp.1_In_Frame_Del_p.E287del|ACADVL_uc010vtq.1_3'UTR|ACADVL_uc002gew.2_In_Frame_Del_p.E255del|ACADVL_uc002gex.2_In_Frame_Del_p.E201del	NM_000018	NP_000009	P49748	ACADV_HUMAN	acyl-Coenzyme A dehydrogenase, very long chain	277	Catalytic.				energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial inner membrane|mitochondrial nucleoid	long-chain-acyl-CoA dehydrogenase activity			ovary(3)	3						GGAGCCGTGAAGGAGAAGATCAC	0.552													25	75	---	---	---	---					
BAHCC1	57597	broad.mit.edu	37	17	79428907	79428909	+	In_Frame_Del	DEL	CAG	-	-			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr17:79428907_79428909delCAG	uc002kaf.2	+	24	7218_7220	c.7218_7220delCAG	c.(7216-7221)CCCAGC>CCC	p.S2410del	BAHCC1_uc002kae.2_In_Frame_Del_p.S1640del	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	2410							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			GCTCAGGCCCCAGCAGCAGCAGC	0.690													2	4	---	---	---	---					
TSHZ1	10194	broad.mit.edu	37	18	72997649	72997651	+	In_Frame_Del	DEL	AGA	-	-			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr18:72997649_72997651delAGA	uc002lly.2	+	2	715_717	c.152_154delAGA	c.(151-156)GAGAAG>GAG	p.K52del		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	97	Ser-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		TCTCGAGAAGAGAAGGAGGATCC	0.586													14	32	---	---	---	---					
EID2B	126272	broad.mit.edu	37	19	40023078	40023081	+	Frame_Shift_Del	DEL	ACAA	-	-			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr19:40023078_40023081delACAA	uc002olz.1	-	1	414_417	c.362_365delTTGT	c.(361-366)TTTGTGfs	p.F121fs		NM_152361	NP_689574	Q96D98	EID2B_HUMAN	EP300 interacting inhibitor of differentiation	121_122					cell differentiation|muscle organ development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;8.61e-26)|all cancers(26;2.76e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GCAGCCTTCCACAAACAGCCTGCG	0.574													18	45	---	---	---	---					
TRIM28	10155	broad.mit.edu	37	19	59061018	59061021	+	Splice_Site	DEL	GTGA	-	-			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr19:59061018_59061021delGTGA	uc002qtg.1	+	13	2271	c.1982_splice	c.e13+1	p.G661_splice	TRIM28_uc010eut.1_Splice_Site_p.G579_splice|TRIM28_uc002qth.1_Splice_Site_p.G276_splice	NM_005762	NP_005753	Q13263	TIF1B_HUMAN	tripartite motif-containing 28 protein						epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	nucleoplasm	chromo shadow domain binding|ligase activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		ATGTACCAGGGTGAGTGTGAGGCT	0.574													87	141	---	---	---	---					
ALMS1	7840	broad.mit.edu	37	2	73746974	73746976	+	In_Frame_Del	DEL	AAC	-	-			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr2:73746974_73746976delAAC	uc002sje.1	+	13	9726_9728	c.9615_9617delAAC	c.(9613-9618)ATAACA>ATA	p.T3207del	ALMS1_uc002sjf.1_In_Frame_Del_p.T3163del|ALMS1_uc002sjg.2_In_Frame_Del_p.T2593del|ALMS1_uc002sjh.1_In_Frame_Del_p.T2593del|ALMS1_uc010fev.1_In_Frame_Del_p.T22del	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3205					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						TCACTCAGATAACAACAGAAAGT	0.384													12	42	---	---	---	---					
EPC2	26122	broad.mit.edu	37	2	149539217	149539218	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr2:149539217_149539218delAG	uc010zbt.1	+	11	1752_1753	c.1725_1726delAG	c.(1723-1728)ACAGGGfs	p.T575fs		NM_015630	NP_056445	Q52LR7	EPC2_HUMAN	enhancer of polycomb homolog 2	575_576					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)|breast(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0516)		TACCAGTAACAGGGGGTATCAC	0.376													16	32	---	---	---	---					
CRIPAK	285464	broad.mit.edu	37	4	1388441	1388442	+	Frame_Shift_Ins	INS	-	CG	CG	rs144787346	byFrequency	TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr4:1388441_1388442insCG	uc003gdf.2	+	1	3102_3103	c.142_143insCG	c.(142-144)ATGfs	p.M48fs		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	48	1.				ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			CTGCTCACACATGCCCATGTGG	0.644													12	1105	---	---	---	---					
SKIV2L2	23517	broad.mit.edu	37	5	54706365	54706367	+	In_Frame_Del	DEL	CTT	-	-			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr5:54706365_54706367delCTT	uc003jpy.3	+	23	2925_2927	c.2659_2661delCTT	c.(2659-2661)CTTdel	p.L888del	SKIV2L2_uc011cqi.1_In_Frame_Del_p.L787del	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	888					maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				TGATGAGCTCCTTCTAACTGAGA	0.350													31	105	---	---	---	---					
IPO11	51194	broad.mit.edu	37	5	61779947	61779949	+	In_Frame_Del	DEL	GAA	-	-			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr5:61779947_61779949delGAA	uc003jtc.2	+	11	1322_1324	c.1132_1134delGAA	c.(1132-1134)GAAdel	p.E380del	IPO11_uc011cqr.1_In_Frame_Del_p.E420del|IPO11_uc003jtb.1_In_Frame_Del_p.E380del	NM_016338	NP_057422	Q9UI26	IPO11_HUMAN	Ran binding protein 11 isoform 2	380						cytoplasm|nucleus	protein binding			lung(2)|skin(2)	4		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		CCTATTAACTGAAGAAGAACTGA	0.330													18	43	---	---	---	---					
PIK3R1	5295	broad.mit.edu	37	5	67589550	67589552	+	In_Frame_Del	DEL	AAG	-	-			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr5:67589550_67589552delAAG	uc003jva.2	+	11	1873_1875	c.1313_1315delAAG	c.(1312-1317)AAAGAA>AAA	p.E439del	PIK3R1_uc003jvb.2_In_Frame_Del_p.E439del|PIK3R1_uc003jvc.2_In_Frame_Del_p.E139del|PIK3R1_uc003jvd.2_In_Frame_Del_p.E169del|PIK3R1_uc003jve.2_In_Frame_Del_p.E118del|PIK3R1_uc011crb.1_In_Frame_Del_p.E109del	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	439					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.D434_Q475del(2)|p.E439del(1)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CAAGTTGTCAAAGAAGATAATAT	0.266			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			10	26	---	---	---	---					
PIK3R1	5295	broad.mit.edu	37	5	67589623	67589624	+	Frame_Shift_Del	DEL	AT	-	-			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr5:67589623_67589624delAT	uc003jva.2	+	11	1946_1947	c.1386_1387delAT	c.(1384-1389)GAATATfs	p.E462fs	PIK3R1_uc003jvb.2_Frame_Shift_Del_p.E462fs|PIK3R1_uc003jvc.2_Frame_Shift_Del_p.E162fs|PIK3R1_uc003jvd.2_Frame_Shift_Del_p.E192fs|PIK3R1_uc003jve.2_Frame_Shift_Del_p.E141fs|PIK3R1_uc011crb.1_Frame_Shift_Del_p.E132fs	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	462_463					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.D434_Q475del(2)|p.D464fs*2(1)|p.?(1)|p.Y463fs*1(1)|p.Y463_L466del(1)|p.T454_D464del(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	AAAGTCGAGAATATGATAGATT	0.287			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			17	37	---	---	---	---					
TCP1	6950	broad.mit.edu	37	6	160201521	160201523	+	In_Frame_Del	DEL	CTT	-	-	rs147802495		TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr6:160201521_160201523delCTT	uc003qsr.2	-	9	1284_1286	c.1049_1051delAAG	c.(1048-1053)GAAGTG>GTG	p.E350del	TCP1_uc003qss.2_In_Frame_Del_p.E195del|TCP1_uc010kjz.2_In_Frame_Del_p.E350del|TCP1_uc003qst.2_In_Frame_Del_p.E126del|SNORA20_uc003qsu.1_5'Flank	NM_030752	NP_110379	P17987	TCPA_HUMAN	T-complex protein 1 isoform a	350					'de novo' posttranslational protein folding|tubulin complex assembly	cell junction|Golgi apparatus	ATP binding|unfolded protein binding			breast(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(65;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)		TCCTGTACCACTTCTTCTGCCTG	0.365													20	121	---	---	---	---					
AEBP1	165	broad.mit.edu	37	7	44152194	44152196	+	In_Frame_Del	DEL	AGA	-	-			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr7:44152194_44152196delAGA	uc003tkb.2	+	18	2560_2562	c.2255_2257delAGA	c.(2254-2259)GAGAAG>GAG	p.K753del	AEBP1_uc003tkc.3_In_Frame_Del_p.K328del|AEBP1_uc003tkd.2_In_Frame_Del_p.K3del	NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	753	Interaction with PTEN (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GCCTGGATGGAGAAGAACCCCTT	0.640													11	133	---	---	---	---					
ZHX2	22882	broad.mit.edu	37	8	123965332	123965333	+	Frame_Shift_Del	DEL	TT	-	-			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr8:123965332_123965333delTT	uc003ypk.1	+	3	2149_2150	c.1582_1583delTT	c.(1582-1584)TTTfs	p.F528fs		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	528						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			GTACCCAGACTTTGCCCCCCAG	0.515													17	121	---	---	---	---					
NOTCH1	4851	broad.mit.edu	37	9	139413070	139413072	+	In_Frame_Del	DEL	AGA	-	-			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chr9:139413070_139413072delAGA	uc004chz.2	-	6	1070_1072	c.1070_1072delTCT	c.(1069-1074)TTCTAC>TAC	p.F357del		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	357	Extracellular (Potential).|EGF-like 9; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CACTCGCAGTAGAAGGAGGCCAC	0.655			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			12	44	---	---	---	---					
PAGE1	8712	broad.mit.edu	37	X	49458759	49458760	+	Frame_Shift_Del	DEL	TT	-	-			TCGA-DU-7300-01A-21D-2086-08	TCGA-DU-7300-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	41bb7bd2-c24e-41ae-881d-25b44ae287ad	2de73131-9a0c-46fc-aa61-6d35f76f75d2	g.chrX:49458759_49458760delTT	uc004dom.2	-	3	241_242	c.108_109delAA	c.(106-111)CAAAGTfs	p.Q36fs		NM_003785	NP_003776	O75459	GAGB1_HUMAN	P antigen family, member 1	36_37					cellular defense response					skin(1)	1	Ovarian(276;0.236)					GAATCCTGACTTTGAGTTGGTG	0.436													9	13	---	---	---	---					
