Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FAM132A	388581	broad.mit.edu	37	1	1179654	1179654	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr1:1179654C>T	uc001adl.1	-	3	328	c.296G>A	c.(295-297)CGG>CAG	p.R99Q		NM_001014980	NP_001014980	Q5T7M4	F132A_HUMAN	family with sequence similarity 132, member A	99						extracellular region					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.22e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GAAGAGATCCCGCTGGGGGGA	0.672000													3	44					0	0	0.115264	0	0
MYOM3	127294	broad.mit.edu	37	1	24392470	24392470	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr1:24392470T>C	uc001bin.3	-	29	3608	c.3445A>G	c.(3445-3447)ACT>GCT	p.T1149A	MYOM3_uc001bil.3_Missense_Mutation_p.T42A|MYOM3_uc001bim.3_Missense_Mutation_p.T806A|MYOM3_uc001bio.2_Missense_Mutation_p.T1149A	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	1149	Ig-like C2-type 3.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		TGAAAGCGAGTCTCCTTCTTG	0.517000													5	160					0	0	0.278610	0	0
DOCK7	85440	broad.mit.edu	37	1	62995074	62995074	+	Silent	SNP	A	G	G			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr1:62995074A>G	uc001daq.2	-	30	3689	c.3655T>C	c.(3655-3657)TTA>CTA	p.L1219L	DOCK7_uc001dan.2_Silent_p.L1080L|DOCK7_uc001dao.2_Silent_p.L1080L|DOCK7_uc001dap.2_Silent_p.L1188L|DOCK7_uc001dam.2_Silent_p.L399L|DOCK7_uc010oov.1_Silent_p.L47L	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1219					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						CTGGAGAGTAAATTGTGTACC	0.408000													35	58					0	0	0.840704	0	0
INSRR	3645	broad.mit.edu	37	1	156814052	156814052	+	Silent	SNP	G	A	A			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr1:156814052G>A	uc010pht.1	-	15	3012	c.2758C>T	c.(2758-2760)CTG>TTG	p.L920L	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	920	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					AGGACATGCAGCCCCCCAGCA	0.562000													4	82					0	0	0.184627	0	0
CCDC19	25790	broad.mit.edu	37	1	159842834	159842834	+	Missense_Mutation	SNP	G	A	A	rs148876212	byFrequency	TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr1:159842834G>A	uc001fui.2	-	11	1495	c.1477C>T	c.(1477-1479)CGG>TGG	p.R493W	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_Missense_Mutation_p.R408W|CCDC19_uc001ful.2_Missense_Mutation_p.R408W	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	493	Potential.					mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			GTGGCAATCCGGTTCTGCACT	0.597000													7	99					0	0	0.307466	0	0
PPFIA4	8497	broad.mit.edu	37	1	203025938	203025938	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr1:203025938C>G	uc001gyz.2	+	6	1342	c.749C>G	c.(748-750)CCC>CGC	p.P250R	PPFIA4_uc009xaj.2_Missense_Mutation_p.P881R|PPFIA4_uc010pqf.1_Missense_Mutation_p.P463R|PPFIA4_uc001gza.2_Missense_Mutation_p.P250R|PPFIA4_uc001gzb.1_5'UTR	NM_015053	NP_055868	O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f	250					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						GGCAGCAACCCCAGCAGCAGC	0.448000													4	11					0	0	0.150653	0	0
RTKN2	219790	broad.mit.edu	37	10	63958003	63958003	+	Silent	SNP	T	C	C			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr10:63958003T>C	uc001jlw.2	-	12	1591	c.1494A>G	c.(1492-1494)AAA>AAG	p.K498K	RTKN2_uc009xpf.1_Intron|RTKN2_uc001jlv.2_Silent_p.K152K	NM_145307	NP_660350	Q8IZC4	RTKN2_HUMAN	rhotekin 2	498					signal transduction	intracellular					0	Prostate(12;0.0297)|all_hematologic(501;0.215)					TCTTTTTCCCTTTTTCATCAT	0.428000													3	182					0	0	0.115264	0	0
HKDC1	80201	broad.mit.edu	37	10	71025449	71025449	+	Silent	SNP	G	C	C			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr10:71025449G>C	uc001jpf.3	+	17	2614	c.2481G>C	c.(2479-2481)CGG>CGC	p.R827R	HKDC1_uc010qje.1_Silent_p.R690R|HKDC1_uc009xqb.2_RNA	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	827					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5						CCGTGTCCCGGCGGGCGGCCC	0.637000													3	84					0	0	0.115264	0	0
PDE6C	5146	broad.mit.edu	37	10	95385365	95385365	+	Nonsense_Mutation	SNP	G	T	T			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr10:95385365G>T	uc001kiu.3	+	5	1036	c.898G>T	c.(898-900)GAA>TAA	p.E300*		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	300	GAF 2.				visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				CAAGCTTGGAGAAGTAGAGCC	0.413000													6	43					0.000157383	0.000166292	0.278610	1	0
C10orf79	80217	broad.mit.edu	37	10	105990414	105990414	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr10:105990414G>A	uc001kxw.2	-	2	369	c.253C>T	c.(253-255)CGG>TGG	p.R85W	C10orf79_uc001kxx.3_Missense_Mutation_p.R85W|C10orf79_uc001kxy.1_Missense_Mutation_p.R85W|C10orf79_uc001kxz.2_Missense_Mutation_p.R85W	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	85											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		TTTAGCTTCCGGTCAGAAAAA	0.423000													50	59					0	0	0.870114	0	0
OR4A16	81327	broad.mit.edu	37	11	55111136	55111136	+	Missense_Mutation	SNP	T	G	G			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr11:55111136T>G	uc010rie.1	+	1	460	c.460T>G	c.(460-462)TCT>GCT	p.S154A		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	154	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						TTTTGTGCACTCTGTGGTTCA	0.453000													10	161					0	0	0.411799	0	0
TRPC6	7225	broad.mit.edu	37	11	101375482	101375482	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr11:101375482C>T	uc001pgk.3	-	2	643	c.218G>A	c.(217-219)CGT>CAT	p.R73H	TRPC6_uc009ywy.2_Missense_Mutation_p.R73H|TRPC6_uc009ywz.1_Missense_Mutation_p.R73H	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	73	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		CCCCTTCTCACGGAGAACTGT	0.463000													68	124					0	0	0.870114	0	0
NLRX1	79671	broad.mit.edu	37	11	119050958	119050958	+	Missense_Mutation	SNP	G	A	A	rs151306288		TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr11:119050958G>A	uc001pvu.2	+	7	2443	c.2228G>A	c.(2227-2229)CGC>CAC	p.R743H	NLRX1_uc010rzc.1_Missense_Mutation_p.R565H|NLRX1_uc001pvv.2_Missense_Mutation_p.R743H|NLRX1_uc001pvw.2_Missense_Mutation_p.R743H|NLRX1_uc001pvx.2_Missense_Mutation_p.R743H	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	743	LRR 2.|Required for the repression of MAVS- induced interferon signaling.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GCTGGGCTGCGCACACTCCTG	0.612000													93	42					0	0	0.870114	0	0
CLEC9A	283420	broad.mit.edu	37	12	10215755	10215755	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr12:10215755T>C	uc001qxa.2	+	7	1034	c.421T>C	c.(421-423)TGT>CGT	p.C141R		NM_207345	NP_997228	Q6UXN8	CLC9A_HUMAN	C-type lectin domain family 9, member A	141	Extracellular (Potential).|C-type lectin.				positive regulation of cytokine secretion|receptor-mediated endocytosis	cell surface|integral to membrane	receptor activity|sugar binding			ovary(1)	1						TCAAGAGAATTGTTTAAAGGA	0.368000													10	103					0	0	0.411799	0	0
LGR5	8549	broad.mit.edu	37	12	71978154	71978154	+	Silent	SNP	C	G	G	rs147161623		TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr12:71978154C>G	uc001swl.2	+	18	2412	c.2364C>G	c.(2362-2364)TCC>TCG	p.S788S	LGR5_uc001swm.2_Silent_p.S764S|LGR5_uc001swn.1_Intron	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	788	Helical; Name=6; (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						TGTCCTTCTCCTCTTTAATAA	0.428000													5	168					0	0	0.184627	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72057258	72057258	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr12:72057258T>C	uc001swo.2	-	1	492	c.133A>G	c.(133-135)AGC>GGC	p.S45G	ZFC3H1_uc010sts.1_Missense_Mutation_p.S45G|ZFC3H1_uc001swp.2_Missense_Mutation_p.S45G|THAP2_uc001swq.2_5'Flank	NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	45	Ser-rich.				RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						CCGCCGCCGCTGCTGCTGCTG	0.637000											OREG0021993	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	141					0	0	0.217242	0	0
CCDC60	160777	broad.mit.edu	37	12	119961500	119961500	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr12:119961500G>A	uc001txe.2	+	11	1571	c.1106G>A	c.(1105-1107)CGC>CAC	p.R369H	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	369										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		GTCCACAGCCGCACTAATTGT	0.567000													3	66					0	0	0.150653	0	0
Unknown	0	broad.mit.edu	37	15	85787868	85787868	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr15:85787868G>A	uc010upj.1	+	6	676	c.611G>A	c.(610-612)CGT>CAT	p.R204H	uc010upk.1_5'Flank	NM_198181	NP_937824			golgi autoantigen, golgin subfamily a, 6D-like																		GAGAGGCTACGTGAACAGGAG	0.552000													4	8					0	0	0.217242	0	0
TP53	7157	broad.mit.edu	37	17	7578524	7578524	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr17:7578524G>C	uc002gim.2	-	5	600	c.406C>G	c.(406-408)CAA>GAA	p.Q136E	TP53_uc002gig.1_Missense_Mutation_p.Q136E|TP53_uc002gih.2_Missense_Mutation_p.Q136E|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Q4E|TP53_uc010cng.1_Missense_Mutation_p.Q4E|TP53_uc002gii.1_Missense_Mutation_p.Q4E|TP53_uc010cnh.1_Missense_Mutation_p.Q136E|TP53_uc010cni.1_Missense_Mutation_p.Q136E|TP53_uc002gij.2_Missense_Mutation_p.Q136E|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Q43E|TP53_uc002gio.2_Missense_Mutation_p.Q4E|TP53_uc010vug.1_Missense_Mutation_p.Q97E	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	136	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> H (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> E (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q136*(28)|p.0?(7)|p.Q136H(5)|p.Q136Q(4)|p.Q136P(3)|p.Q136E(3)|p.N131fs*27(2)|p.Q136fs*13(2)|p.Q136R(2)|p.Q136fs*34(2)|p.V73fs*9(1)|p.F134_T140>S(1)|p.C135_T140delCQLAKT(1)|p.Q136K(1)|p.Y126fs*11(1)|p.C135_A138delCQLA(1)|p.K132_A138delKMFCQLA(1)|p.S127_Q136del10(1)|p.Q136_K139delQLAK(1)|p.C135_Q136insX(1)|p.C135_Q136insXXXXXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTGGCCAGTTGGCAAAACATC	0.562000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			70	4					0	0	0.870114	0	0
FAM117A	81558	broad.mit.edu	37	17	47841412	47841412	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr17:47841412G>A	uc002ipk.2	-	1	107	c.38C>T	c.(37-39)GCC>GTC	p.A13V	FAM117A_uc010wlz.1_Intron	NM_030802	NP_110429	Q9C073	F117A_HUMAN	family with sequence similarity 117, member A	13										ovary(1)	1						cggcccccaggcacctccgcc	0.522000													4	6					0	0	0.184627	0	0
RGS9	8787	broad.mit.edu	37	17	63223460	63223460	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr17:63223460G>A	uc002jfe.2	+	19	2070	c.1960G>A	c.(1960-1962)GGA>AGA	p.G654R	RGS9_uc002jfd.2_Missense_Mutation_p.G651R|RGS9_uc002jff.2_RNA|RGS9_uc002jfg.2_Missense_Mutation_p.G425R	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	654					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						GGAGGATGCTGGAACAGGAGA	0.577000													3	92					0	0	0.150653	0	0
DSG3	1830	broad.mit.edu	37	18	29054105	29054105	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr18:29054105C>T	uc002kws.2	+	15	2232	c.2123C>T	c.(2122-2124)GCC>GTC	p.A708V	DSG3_uc002kwt.2_5'UTR	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	708	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AATACGTATGCCAGAGGCACA	0.438000													6	126					0	0	0.217242	0	0
PLIN5	440503	broad.mit.edu	37	19	4529865	4529865	+	Silent	SNP	G	A	A			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr19:4529865G>A	uc002mas.2	-	4	323	c.270C>T	c.(268-270)AAC>AAT	p.N90N	PLIN5_uc002mat.1_Silent_p.N90N	NM_001013706	NP_001013728	Q00G26	PLIN5_HUMAN	lipid storage droplet protein 5	90						lipid particle					0						AGGCGAGGCTGTTCATAGTGG	0.353000													3	70					0	0	0.115264	0	0
C19orf56	51398	broad.mit.edu	37	19	12779410	12779410	+	Missense_Mutation	SNP	C	T	T	rs144906540		TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr19:12779410C>T	uc002mud.2	-	3	426	c.178G>A	c.(178-180)GCT>ACT	p.A60T	MAN2B1_uc002mub.2_5'Flank|MAN2B1_uc010dyv.1_5'Flank|WDR83_uc002mue.3_5'UTR|WDR83_uc002muc.2_RNA|WDR83_uc010dyw.2_5'Flank	NM_016145	NP_057229	Q9Y284	CS056_HUMAN	hypothetical protein LOC51398	60	Helical; (Potential).					integral to membrane					0						CAGTAGACAGCGACCCAAGCA	0.522000													3	75					0	0	0.115264	0	0
ARHGEF1	9138	broad.mit.edu	37	19	42396179	42396179	+	Silent	SNP	C	T	T			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr19:42396179C>T	uc002orx.2	+	5	418	c.309C>T	c.(307-309)TTC>TTT	p.F103F	ARHGEF1_uc002orw.1_Silent_p.F103F|ARHGEF1_uc002ory.2_Intron|ARHGEF1_uc002orz.2_5'UTR|ARHGEF1_uc002osa.2_Silent_p.F118F|ARHGEF1_uc002osb.2_Intron	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	103	RGSL.				cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		ACCACAGCTTCCTGGAGAAGA	0.612000													29	33					0	0	0.788014	0	0
MEGF8	1954	broad.mit.edu	37	19	42857651	42857651	+	Silent	SNP	G	A	A			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr19:42857651G>A	uc002otl.3	+	20	4019	c.3384G>A	c.(3382-3384)CGG>CGA	p.R1128R	MEGF8_uc002otm.3_Silent_p.R736R	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	1195	Extracellular (Potential).|Laminin EGF-like 1.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				AACGATGCCGGCCCGGCAGCT	0.682000													5	29					0	0	0.217242	0	0
ZNF845	91664	broad.mit.edu	37	19	53855364	53855365	+	Missense_Mutation	DNP	CA	TG	TG			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr19:53855364_53855365CA>TG	uc010ydv.1	+	4	1553_1554	c.1436_1437CA>TG	c.(1435-1437)ACA>ATG	p.T479M	ZNF845_uc010ydw.1_Missense_Mutation_p.T479M	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	479	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCAGTCAGACATCATCCCTTG	0.381000													6	105					0	0	0.115264	0	0
SLC20A1	6574	broad.mit.edu	37	2	113418061	113418061	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr2:113418061G>A	uc002tib.2	+	9	2151	c.1705G>A	c.(1705-1707)GGT>AGT	p.G569S	SLC20A1_uc002tic.1_Missense_Mutation_p.G381S	NM_005415	NP_005406	Q8WUM9	S20A1_HUMAN	solute carrier family 20 (phosphate	569	Helical; (Potential).				phosphate metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to plasma membrane	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity			ovary(2)	2						ACTCTATGGTGGTGTTGGTAT	0.468000													3	161					0	0	0.150653	0	0
WDR33	55339	broad.mit.edu	37	2	128477431	128477431	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr2:128477431G>A	uc002tpg.1	-	16	2351	c.2168C>T	c.(2167-2169)CCT>CTT	p.P723L		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	723	Collagen-like.				postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		CTGAGGGCCAGGCGGGCCTTG	0.632000													5	81					0	0	0.248553	0	0
NEB	4703	broad.mit.edu	37	2	152383461	152383461	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr2:152383461C>T	uc010fnx.2	-	120	17004	c.16813G>A	c.(16813-16815)GCC>ACC	p.A5605T	NEB_uc002txr.2_Missense_Mutation_p.A2028T|NEB_uc002txt.3_Missense_Mutation_p.A110T	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5605	Nebulin 153.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCCTGAGGGCGAGCACCGTG	0.463000													6	9					0	0	0.248553	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								35	74					0	0	0.847076	0	0
NTSR1	4923	broad.mit.edu	37	20	61340986	61340986	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr20:61340986G>A	uc002ydf.2	+	1	798	c.427G>A	c.(427-429)GGC>AGC	p.G143S		NM_002531	NP_002522	P30989	NTR1_HUMAN	neurotensin receptor 1	143	Helical; Name=3; (Potential).					endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			skin(2)|lung(1)|central_nervous_system(1)	4	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			CGGCTGCCGCGGCTACTACTT	0.677000													3	67					0	0	0.184627	0	0
UBASH3A	53347	broad.mit.edu	37	21	43838614	43838614	+	Silent	SNP	C	T	T	rs147873921		TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr21:43838614C>T	uc002zbe.2	+	7	978	c.942C>T	c.(940-942)AGC>AGT	p.S314S	UBASH3A_uc002zbf.2_Silent_p.S276S|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Silent_p.S276S	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	314	SH3.					cytosol|nucleus				ovary(3)	3						ACGAAGCCAGCGAGGGCTGGG	0.592000													3	75					0	0	0.115264	0	0
CHEK2	11200	broad.mit.edu	37	22	29090043	29090043	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr22:29090043C>T	uc003adu.1	-	13	1510	c.1438G>A	c.(1438-1440)GCC>ACC	p.A480T	CHEK2_uc003ads.1_Missense_Mutation_p.A259T|CHEK2_uc010gvh.1_Missense_Mutation_p.A389T|CHEK2_uc010gvi.1_Intron|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Missense_Mutation_p.A523T|CHEK2_uc003adv.1_Missense_Mutation_p.A451T|CHEK2_uc003adw.1_Missense_Mutation_p.A480T|CHEK2_uc003adx.1_Missense_Mutation_p.A259T|CHEK2_uc003ady.1_Missense_Mutation_p.A469T|CHEK2_uc003adz.1_Missense_Mutation_p.A284T	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	480	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						TGTCTTAAGGCTTCTTCTGTC	0.488000			F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				97	131					0	0	0.870114	0	0
MAPK12	6300	broad.mit.edu	37	22	50693717	50693717	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr22:50693717G>C	uc003bkm.1	-	11	1084	c.933C>G	c.(931-933)TTC>TTG	p.F311L	MAPK12_uc003bkn.2_Missense_Mutation_p.F130L|MAPK12_uc003bko.2_Missense_Mutation_p.F221L|MAPK12_uc003bkl.1_Missense_Mutation_p.F301L|MAPK12_uc003bkp.2_Missense_Mutation_p.F96L|MAPK12_uc003bkq.2_Missense_Mutation_p.F130L	NM_002969	NP_002960	P53778	MK12_HUMAN	mitogen-activated protein kinase 12	311	Protein kinase.				cell cycle arrest|DNA damage induced protein phosphorylation|muscle organ development|myoblast differentiation|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction	mitochondrion|nucleoplasm	ATP binding|magnesium ion binding|MAP kinase activity|protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCAGGGACTCGAAGTAGGGAT	0.612000													60	66					0	0	0.870114	0	0
GOLGA4	2803	broad.mit.edu	37	3	37369109	37369109	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr3:37369109A>G	uc003cgv.2	+	14	6036	c.5732A>G	c.(5731-5733)CAT>CGT	p.H1911R	GOLGA4_uc010hgr.1_Missense_Mutation_p.H1472R|GOLGA4_uc003cgw.2_Missense_Mutation_p.H1933R|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Missense_Mutation_p.H1792R	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	1911	Potential.|Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						TCCAAATCACATTTGGTCCAA	0.403000													49	51					0	0	0.870114	0	0
Unknown	0	broad.mit.edu	37	3	95374179	95374179	+	RNA	SNP	C	T	T			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr3:95374179C>T	uc003dro.1	-	5		c.1683G>A								Homo sapiens cDNA FLJ34909 fis, clone NT2RI2009301, moderately similar to BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL PRECURSOR.																		GATATTCTAACGGTGGCATCA	0.418000													15	25					0	0	0.539581	0	0
UGT2B10	7365	broad.mit.edu	37	4	69870669	69870669	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr4:69870669C>A	uc011cao.1	-	9	1517	c.1381G>T	c.(1381-1383)GCT>TCT	p.A461S	UGT2B10_uc011can.1_Missense_Mutation_p.A377S			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	498	Helical; (Potential).				lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						GCCACACAGGCCAGCAGGAAC	0.448000													15	171					2.31682e-05	2.49504e-05	0.479597	1	0
AMACR	23600	broad.mit.edu	37	5	33989379	33989379	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr5:33989379A>G	uc003jig.2	-	5	1050	c.968T>C	c.(967-969)GTG>GCG	p.V323A	AMACR_uc003jih.2_3'UTR|AMACR_uc003jii.2_Missense_Mutation_p.V308A|AMACR_uc003jij.2_Missense_Mutation_p.V323A	NM_014324	NP_055139	Q9UHK6	AMACR_HUMAN	alpha-methylacyl-CoA racemase isoform 1	323					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	mitochondrion|peroxisomal matrix	alpha-methylacyl-CoA racemase activity				0						GCGGGGGCTCACGTCCTGCTC	0.507000													42	82					0	0	0.870114	0	0
ARSI	340075	broad.mit.edu	37	5	149676821	149676821	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr5:149676821A>G	uc003lrv.2	-	2	2255	c.1666T>C	c.(1666-1668)TTT>CTT	p.F556L		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	556						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTACGGAAAAAGGATCGAAGC	0.537000													3	138					0	0	0.184627	0	0
OR10C1	442194	broad.mit.edu	37	6	29408070	29408070	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr6:29408070G>A	uc011dlp.1	+	1	278	c.278G>A	c.(277-279)CGC>CAC	p.R93H	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CACATCTCTCGCTCTGGATGT	0.587000													51	65					0	0	0.870114	0	0
LOC442308	442308	broad.mit.edu	37	7	55713546	55713546	+	RNA	SNP	G	C	C			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr7:55713546G>C	uc010kzj.2	+	1		c.235G>C				NR_003598				Homo sapiens similar to tubulin, beta 5 (LOC442308), non-coding RNA.												0						TGTTCACTCAGGTCCTTTTGG	0.522000													27	53					0	0	0.740014	0	0
ZNF425	155054	broad.mit.edu	37	7	148809259	148809259	+	Missense_Mutation	SNP	T	A	A			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr7:148809259T>A	uc003wfj.2	-	3	347	c.274A>T	c.(274-276)ATG>TTG	p.M92L		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	92					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			GTATTCTTCATGTTCAACTGT	0.363000													16	177					0	0	0.520397	0	0
UNC5D	137970	broad.mit.edu	37	8	35583683	35583683	+	Silent	SNP	C	T	T			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr8:35583683C>T	uc003xjr.1	+	10	1645	c.1317C>T	c.(1315-1317)CTC>CTT	p.L439L	UNC5D_uc003xjs.1_Silent_p.L434L|UNC5D_uc003xju.1_Silent_p.L15L|UNC5D_uc003xjt.1_Silent_p.L197L	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	439	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		ACTCCCTGCTCCTGAATTCTG	0.502000													8	129					0	0	0.387290	0	0
FBXO43	286151	broad.mit.edu	37	8	101146458	101146458	+	Silent	SNP	T	C	C			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr8:101146458T>C	uc003yjd.2	-	4	2522	c.1809A>G	c.(1807-1809)GGA>GGG	p.G603G	FBXO43_uc003yje.2_Silent_p.G569G	NM_001029860	NP_001025031	Q4G163	FBX43_HUMAN	F-box protein 43 isoform b	603					meiosis		zinc ion binding			kidney(1)|skin(1)	2	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			TCAAAACTTCTCCCCAGGGAG	0.408000													58	57					0	0	0.870114	0	0
LAMC3	10319	broad.mit.edu	37	9	133942444	133942444	+	Silent	SNP	C	T	T	rs145571152	byFrequency	TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr9:133942444C>T	uc004caa.1	+	14	2543	c.2445C>T	c.(2443-2445)AAC>AAT	p.N815N		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	815	Laminin EGF-like 8.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		GTAGCGGGAACGTGGACCCCA	0.647000													5	39					0	0	0.184627	0	0
OR4F5	79501	broad.mit.edu	37	1	69454	69454	+	Frame_Shift_Del	DEL	C	-	-			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr1:69454delC	uc001aal.1	+	1	364	c.364delC	c.(364-366)CCCfs	p.P122fs		NM_001005484	NP_001005484	Q8NH21	OR4F5_HUMAN	olfactory receptor, family 4, subfamily F,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;3.48e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.21e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000469)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		AATATGCAAGCCCCTACACTA	0.478													2	4	---	---	---	---					
NOTCH2	4853	broad.mit.edu	37	1	120491679	120491680	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr1:120491679_120491680delCT	uc001eik.2	-	16	2805_2806	c.2549_2550delAG	c.(2548-2550)GAGfs	p.E850fs	NOTCH2_uc001eil.2_Frame_Shift_Del_p.E850fs	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	850	Extracellular (Potential).|EGF-like 22.				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		AATTTGGTGACTCTTTGCAAAC	0.431			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome		OREG0013733	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	201	---	---	---	---					
NOTCH2	4853	broad.mit.edu	37	1	120497724	120497725	+	Frame_Shift_Ins	INS	-	T	T			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr1:120497724_120497725insT	uc001eik.2	-	13	2413_2414	c.2157_2158insA	c.(2155-2160)TCACAGfs	p.S719fs	NOTCH2_uc001eil.2_Frame_Shift_Ins_p.S719fs|NOTCH2_uc001eim.3_Frame_Shift_Ins_p.S636fs	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	719_720	EGF-like 19.|Extracellular (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCGTTCACCTGTGAGTAGCAGC	0.535			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				9	141	---	---	---	---					
RNASEH2C	84153	broad.mit.edu	37	11	65487791	65487793	+	In_Frame_Del	DEL	CTT	-	-			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr11:65487791_65487793delCTT	uc001ofn.2	-	2	448_450	c.268_270delAAG	c.(268-270)AAGdel	p.K90del	RNASEH2C_uc001ofm.2_RNA	NM_032193	NP_115569	Q8TDP1	RNH2C_HUMAN	ribonuclease H2, subunit C	90					RNA catabolic process	nucleus|ribonuclease H2 complex					0						CCATCGACACCTTCTTCTCTTCT	0.621													13	147	---	---	---	---					
TMC4	147798	broad.mit.edu	37	19	54672374	54672376	+	In_Frame_Del	DEL	AGA	-	-	rs143105109		TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr19:54672374_54672376delAGA	uc010erf.2	-	4	623_625	c.491_493delTCT	c.(490-495)TTCTCC>TCC	p.F164del	TMC4_uc002qdo.2_In_Frame_Del_p.F158del	NM_001145303	NP_001138775	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4 isoform 1	164	Extracellular (Potential).					integral to membrane				pancreas(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CGCAGCAGGGAGAAGTAGGACTC	0.670											OREG0025670	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	0	---	---	---	---					
DHX35	60625	broad.mit.edu	37	20	37591029	37591029	+	Frame_Shift_Del	DEL	C	-	-			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr20:37591029delC	uc002xjh.2	+	1	30	c.19delC	c.(19-21)CCGfs	p.P7fs	DHX35_uc010zwa.1_5'UTR|DHX35_uc010zwb.1_5'UTR|DHX35_uc010zwc.1_Frame_Shift_Del_p.P7fs	NM_021931	NP_068750	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	7						catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			lung(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				GCCCGTGGGACCGGTGAAGTT	0.721													16	14	---	---	---	---					
DHX30	22907	broad.mit.edu	37	3	47888021	47888023	+	In_Frame_Del	DEL	ATC	-	-			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr3:47888021_47888023delATC	uc003cru.2	+	11	1885_1887	c.1459_1461delATC	c.(1459-1461)ATCdel	p.I488del	DHX30_uc003crt.2_In_Frame_Del_p.I449del	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	488	Helicase ATP-binding.					mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		CTGCAATGTTATCATCACCCAAC	0.650													64	167	---	---	---	---					
LNP1	348801	broad.mit.edu	37	3	100148586	100148588	+	In_Frame_Del	DEL	GAT	-	-			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr3:100148586_100148588delGAT	uc003dtx.3	+	2	1293_1295	c.13_15delGAT	c.(13-15)GATdel	p.D10del	LNP1_uc003dty.3_RNA|LNP1_uc011bhb.1_RNA	NM_001085451	NP_001078920	A1A4G5	LNP1_HUMAN	leukemia NUP98 fusion partner 1	10	Poly-Asp.										0						GGAGCACAAAGATGATGATGATG	0.507													10	428	---	---	---	---					
ANK2	287	broad.mit.edu	37	4	114214679	114214681	+	In_Frame_Del	DEL	CAC	-	-			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr4:114214679_114214681delCAC	uc003ibe.3	+	22	2560_2562	c.2460_2462delCAC	c.(2458-2463)GTCACC>GTC	p.T826del	ANK2_uc003ibd.3_In_Frame_Del_p.T805del|ANK2_uc003ibf.3_In_Frame_Del_p.T826del|ANK2_uc011cgc.1_In_Frame_Del_p.T35del|ANK2_uc003ibc.2_In_Frame_Del_p.T802del|ANK2_uc011cgb.1_In_Frame_Del_p.T841del	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	826					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CTGAGGAGGTCACCACCACCACC	0.443													8	75	---	---	---	---					
SLC7A11	23657	broad.mit.edu	37	4	139144383	139144386	+	Frame_Shift_Del	DEL	TAAT	-	-			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr4:139144383_139144386delTAAT	uc011chb.1	-	4	893_896	c.613_616delATTA	c.(613-618)ATTATAfs	p.I205fs		NM_014331	NP_055146	Q9UPY5	XCT_HUMAN	solute carrier family 7, (cationic amino acid	205_206	Helical; (Potential).				blood coagulation|cellular nitrogen compound metabolic process|leukocyte migration|response to toxin	integral to membrane|plasma membrane	cystine:glutamate antiporter activity|protein binding			skin(1)	1	all_hematologic(180;0.166)				L-Cystine(DB00138)|L-Glutamic Acid(DB00142)|Sulfasalazine(DB00795)	CCAGGGACTATAATTATCAGAATT	0.387													7	91	---	---	---	---					
FSTL5	56884	broad.mit.edu	37	4	162697089	162697089	+	Frame_Shift_Del	DEL	T	-	-			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr4:162697089delT	uc003iqh.2	-	5	983	c.547delA	c.(547-549)ATGfs	p.M183fs	FSTL5_uc003iqi.2_Frame_Shift_Del_p.M182fs|FSTL5_uc010iqv.2_Frame_Shift_Del_p.M182fs	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	183	EF-hand 1.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TATTTAAACATTTGATCCACC	0.284													47	27	---	---	---	---					
NOTCH1	4851	broad.mit.edu	37	9	139393364	139393365	+	Frame_Shift_Del	DEL	AT	-	-			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chr9:139393364_139393365delAT	uc004chz.2	-	33	6166_6167	c.6166_6167delAT	c.(6166-6168)ATGfs	p.M2056fs		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	2056	Cytoplasmic (Potential).|ANK 4.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.M2057fs*211(1)		haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GTTGTTCTGCATATCTTTGTTA	0.609			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			8	313	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76938271	76938272	+	Frame_Shift_Del	DEL	TT	-	-			TCGA-DU-7301-01A-11D-2086-08	TCGA-DU-7301-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba94c29b-b76e-4d67-bf5a-ce6bc45d85f8	536cb58b-852c-491a-94f7-ffbea4c98871	g.chrX:76938271_76938272delTT	uc004ecp.3	-	9	2708_2709	c.2476_2477delAA	c.(2476-2478)AAGfs	p.K826fs	ATRX_uc004ecq.3_Frame_Shift_Del_p.K788fs|ATRX_uc004eco.3_Frame_Shift_Del_p.K611fs|ATRX_uc004ecr.2_Frame_Shift_Del_p.K758fs|ATRX_uc010nlx.1_Frame_Shift_Del_p.K797fs|ATRX_uc010nly.1_Frame_Shift_Del_p.K771fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	826					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	actcatgctctttatctctttt	0.223			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						64	14	---	---	---	---					
