Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PLA2G4A	5321	broad.mit.edu	37	1	186948459	186948459	+	Missense_Mutation	SNP	A	G	G			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr1:186948459A>G	uc001gsc.2	+	17	2178	c.1973A>G	c.(1972-1974)GAA>GGA	p.E658G	PLA2G4A_uc010pos.1_Missense_Mutation_p.E598G	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA	658	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	GTTCCAAGGGAAACTGAGGAA	0.333000													8	140					0	0	0.047766	0	0
OR8I2	120586	broad.mit.edu	37	11	55860898	55860898	+	Missense_Mutation	SNP	G	C	C			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr11:55860898G>C	uc010rix.1	+	1	115	c.115G>C	c.(115-117)GTT>CTT	p.V39L		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	39	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					TCTATTCACTGTTTTGGGAAA	0.378000													157	314					0	0	0.048971	0	0
B3GAT3	26229	broad.mit.edu	37	11	62389342	62389342	+	Missense_Mutation	SNP	C	A	A			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr11:62389342C>A	uc001ntw.2	-	1	107	c.78G>T	c.(76-78)CAG>CAT	p.Q26H	B3GAT3_uc009ynz.2_5'UTR|B3GAT3_uc001ntx.2_Intron|B3GAT3_uc010rlz.1_Missense_Mutation_p.Q26H	NM_012200	NP_036332	O94766	B3GA3_HUMAN	beta-1,3-glucuronyltransferase 3	26	Helical; Signal-anchor for type II membrane protein; (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|manganese ion binding				0						gcTCACCGAGCTGTACCAGCG	0.373000													4	25					0.00909568	0.00985365	0.009096	1	0
KIAA1377	57562	broad.mit.edu	37	11	101818852	101818852	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr11:101818852G>A	uc001pgm.2	+	4	755	c.485G>A	c.(484-486)CGT>CAT	p.R162H	KIAA1377_uc001pgn.2_Missense_Mutation_p.R118H|KIAA1377_uc009yxa.1_5'UTR	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	162							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		CCCTTTTCCCGTAGACCAACA	0.348000													44	72					0	0	0.111260	0	0
ARID2	196528	broad.mit.edu	37	12	46242662	46242662	+	Nonsense_Mutation	SNP	C	T	T			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr12:46242662C>T	uc001ros.1	+	13	1624	c.1624C>T	c.(1624-1626)CGA>TGA	p.R542*	ARID2_uc001ror.2_Nonsense_Mutation_p.R542*|ARID2_uc009zkg.1_5'UTR|ARID2_uc009zkh.1_Nonsense_Mutation_p.R169*|ARID2_uc001rou.1_5'Flank	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	542	RFX-type winged-helix.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TTCTGTTTCTCGAGCAGAAAT	0.343000													46	91					0	0	0.039052	0	0
MED13L	23389	broad.mit.edu	37	12	116460278	116460278	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr12:116460278G>A	uc001tvw.2	-	5	663	c.608C>T	c.(607-609)TCA>TTA	p.S203L		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	203					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		TGGTGCAGGTGAAGACTGAGC	0.473000													13	34					0	0	0.020292	0	0
OR11H4	390442	broad.mit.edu	37	14	20710969	20710969	+	Missense_Mutation	SNP	G	C	C			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr14:20710969G>C	uc010tld.1	+	1	19	c.19G>C	c.(19-21)GAC>CAC	p.D7H		NM_001004479	NP_001004479	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		CTTCTTTGTAGACTTAAGACC	0.418000													4	98					0	0	0.021553	0	0
RPP25	54913	broad.mit.edu	37	15	75248608	75248608	+	Nonsense_Mutation	SNP	C	T	T			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr15:75248608C>T	uc002azj.1	-	1	1168	c.317G>A	c.(316-318)TGG>TAG	p.W106*		NM_017793	NP_060263	Q9BUL9	RPP25_HUMAN	ribonuclease P 25kDa subunit	106					tRNA processing	nucleus	protein binding|ribonuclease P activity|RNA binding				0						GAGGCTCTGCCACACCTCGCG	0.692000													2	5					0	0	0.004672	0	0
KIAA1024	23251	broad.mit.edu	37	15	79755572	79755572	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr15:79755572C>T	uc002bew.1	+	3	2537	c.2462C>T	c.(2461-2463)GCC>GTC	p.A821V	KIAA1024_uc010unk.1_Missense_Mutation_p.A821V	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	821						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						ACCGAGTTGGCCGAGGTGAAG	0.622000													4	177					0	0	0.009096	0	0
TP53	7157	broad.mit.edu	37	17	7577099	7577099	+	Missense_Mutation	SNP	C	T	T	rs121912660		TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr17:7577099C>T	uc002gim.2	-	8	1033	c.839G>A	c.(838-840)AGA>AAA	p.R280K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R280K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R148K|TP53_uc010cng.1_Missense_Mutation_p.R148K|TP53_uc002gii.1_Missense_Mutation_p.R148K|TP53_uc010cnh.1_Missense_Mutation_p.R280K|TP53_uc010cni.1_Missense_Mutation_p.R280K|TP53_uc002gij.2_Missense_Mutation_p.R280K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	280	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> T (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(53)|p.R280K(41)|p.R280G(18)|p.R280S(13)|p.R280I(12)|p.R280*(8)|p.R280fs*65(7)|p.0?(7)|p.R280R(3)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.G279_R280delGR(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.G279fs*59(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.D281fs*24(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCCGGTCTCTCCCAGGACA	0.542000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			64	20					0	0	0.048971	0	0
SRCIN1	80725	broad.mit.edu	37	17	36714502	36714502	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr17:36714502C>T	uc002hqd.2	-	11	2387	c.2162G>A	c.(2161-2163)CGC>CAC	p.R721H	SRCIN1_uc002hqf.1_Missense_Mutation_p.R593H|SRCIN1_uc002hqe.2_Missense_Mutation_p.R575H|SRCIN1_uc002hqg.2_Missense_Mutation_p.R27H	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	593	Potential.				exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0						GTTGAGATAGCGCAGCCGTTC	0.701000											OREG0024362	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	49					0	0	0.104719	0	0
C17orf62	79415	broad.mit.edu	37	17	80407088	80407088	+	Missense_Mutation	SNP	G	C	C			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr17:80407088G>C	uc002kez.2	-	1	91	c.43C>G	c.(43-45)CTG>GTG	p.L15V	C17orf62_uc002key.2_5'Flank|C17orf62_uc002kfa.2_Missense_Mutation_p.L15V|C17orf62_uc010dir.2_Missense_Mutation_p.L15V|C17orf62_uc002kfb.3_Missense_Mutation_p.L15V|C17orf62_uc002kfc.3_Missense_Mutation_p.L15V|C17orf62_uc002kfd.3_Translation_Start_Site|C17orf62_uc002kfe.3_Intron|C17orf62_uc010dis.1_Missense_Mutation_p.L15V	NM_001100407	NP_001093877	Q9BQA9	CQ062_HUMAN	hypothetical protein LOC79415 isoform a	15						integral to membrane	protein binding				0	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			GCCCTCTTCAGATGGAGGCGG	0.617000													11	3					0	0	0.093190	0	0
EMILIN2	84034	broad.mit.edu	37	18	2913269	2913269	+	Missense_Mutation	SNP	T	C	C			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr18:2913269T>C	uc002kln.2	+	8	3188	c.3029T>C	c.(3028-3030)CTC>CCC	p.L1010P		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	1010	C1q.				cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		GCATTCCACCTCATCGTGCAC	0.592000													32	57					0	0	0.045705	0	0
FZR1	51343	broad.mit.edu	37	19	3532532	3532532	+	Missense_Mutation	SNP	G	C	C			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr19:3532532G>C	uc010dtk.2	+	10	1160	c.1126G>C	c.(1126-1128)GGC>CGC	p.G376R	FZR1_uc002lxt.2_Missense_Mutation_p.G376R|FZR1_uc002lxv.2_Missense_Mutation_p.G287R	NM_001136198	NP_001129670	Q9UM11	FZR_HUMAN	Fzr1 protein isoform 1	376	WD 5.				activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|DNA repair|G2/M transition DNA damage checkpoint|mitosis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding			lung(1)|kidney(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCGGGGGGCGGCACAGCTGA	0.652000													7	53					0	0	0.029380	0	0
FUT6	2528	broad.mit.edu	37	19	5832317	5832317	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr19:5832317C>T	uc002mdf.1	-	4	788	c.262G>A	c.(262-264)GCT>ACT	p.A88T	FUT6_uc002mdg.1_Missense_Mutation_p.A88T|FUT6_uc002mdh.1_Missense_Mutation_p.A88T|FUT6_uc010dul.1_Missense_Mutation_p.A88T	NM_001040701	NP_001035791	P51993	FUT6_HUMAN	fucosyltransferase 6	88	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity				0						TTGCAGTCAGCCGTGCCAGGC	0.622000													4	116					0	0	0.014758	0	0
KCNH7	90134	broad.mit.edu	37	2	163302583	163302583	+	Missense_Mutation	SNP	T	C	C			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr2:163302583T>C	uc002uch.1	-	7	1711	c.1499A>G	c.(1498-1500)GAC>GGC	p.D500G	KCNH7_uc002uci.2_Missense_Mutation_p.D493G	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	500	Helical; Name=Segment S3; (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	TGCAACCATGTCAATCAGGAA	0.353000													4	123					0	0	0.014758	0	0
TTN	7273	broad.mit.edu	37	2	179456089	179456089	+	Silent	SNP	G	A	A			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr2:179456089G>A	uc010zfg.1	-	253	52883	c.52659C>T	c.(52657-52659)ACC>ACT	p.T17553T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.T11248T|TTN_uc010zfi.1_Silent_p.T11181T|TTN_uc010zfj.1_Silent_p.T11056T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18480							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTGCTCATCGGTTTTAATCT	0.433000													276	534					0	0	0.048971	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								45	96					0	0	0.042209	0	0
SLC23A3	151295	broad.mit.edu	37	2	220034279	220034279	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr2:220034279C>T	uc010zks.1	-	2	395	c.284G>A	c.(283-285)GGT>GAT	p.G95D	NHEJ1_uc002vjq.3_Splice_Site|SLC23A3_uc010zkr.1_Missense_Mutation_p.G95D|SLC23A3_uc010fwb.2_Missense_Mutation_p.G95D|SLC23A3_uc002vjs.1_5'Flank|SLC23A3_uc002vjt.1_5'Flank	NM_001144889	NP_001138361	Q6PIS1	S23A3_HUMAN	solute carrier family 23 (nucleobase	95	Helical; (Potential).				transmembrane transport	integral to membrane	protein binding|transporter activity				0		Renal(207;0.0474)		Epithelial(149;9.27e-07)|all cancers(144;0.000156)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGTAGACATACCACATGAAAA	0.582000													97	240					0	0	0.048971	0	0
CHD6	84181	broad.mit.edu	37	20	40045243	40045243	+	Silent	SNP	C	T	T			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr20:40045243C>T	uc002xka.1	-	33	6649	c.6471G>A	c.(6469-6471)GCG>GCA	p.A2157A	CHD6_uc002xjz.1_5'Flank	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2157					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				GGATCTGGGCCGCCAATGCTG	0.522000													79	161					0	0	0.048971	0	0
LOC96610	96610	broad.mit.edu	37	22	22664141	22664141	+	RNA	SNP	G	A	A			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr22:22664141G>A	uc011aim.1	+	30		c.1998G>A			LOC96610_uc011aiq.1_RNA					Parts of antibodies, mostly variable regions.												0						AAATTTGAAGGTGCTGTGATT	0.448000													4	129					0	0	0.009096	0	0
CACNA2D3	55799	broad.mit.edu	37	3	55052339	55052339	+	Silent	SNP	C	T	T			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr3:55052339C>T	uc003dhf.2	+	35	3030	c.2982C>T	c.(2980-2982)TGC>TGT	p.C994C	CACNA2D3_uc003dhg.1_Silent_p.C900C|CACNA2D3_uc003dhh.1_RNA	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	994	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		GTGAAGACTGCTCCAAGTAAG	0.502000													16	33					0	0	0.024245	0	0
SENP7	57337	broad.mit.edu	37	3	101177814	101177814	+	Missense_Mutation	SNP	T	G	G			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr3:101177814T>G	uc003dut.2	-	4	380	c.269A>C	c.(268-270)AAG>ACG	p.K90T	SENP7_uc003duu.2_Missense_Mutation_p.K90T|SENP7_uc003duv.2_Missense_Mutation_p.K57T|SENP7_uc003duw.2_Missense_Mutation_p.K90T|SENP7_uc003dux.2_Missense_Mutation_p.K57T	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	sentrin/SUMO-specific protease 7 isoform 1	90				K -> R (in Ref. 3; CAB66534).	proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5						TGGTGATGACTTGGAAGTAAC	0.294000													75	368					0	0	0.048971	0	0
PLXNA1	5361	broad.mit.edu	37	3	126724979	126724979	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr3:126724979C>T	uc003ejg.2	+	7	1890	c.1886C>T	c.(1885-1887)GCG>GTG	p.A629V		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	652	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		AAGAAGTTTGCGTCTGTGGAC	0.602000													5	205					0	0	0.014758	0	0
ZMAT3	64393	broad.mit.edu	37	3	178748788	178748788	+	Splice_Site	SNP	C	G	G			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr3:178748788C>G	uc003fjg.2	-	3	530	c.271_splice	c.e3-1	p.G91_splice	ZMAT3_uc010hxa.2_Splice_Site_p.G91_splice|ZMAT3_uc003fji.2_Splice_Site_p.G91_splice	NM_022470	NP_071915	Q9HA38	ZMAT3_HUMAN	p53 target zinc finger protein isoform 1						apoptosis|protein transport|regulation of growth|response to DNA damage stimulus|transmembrane transport	nucleolus	RNA binding|zinc ion binding			ovary(2)	2	all_cancers(143;3.31e-18)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;6.74e-27)|GBM - Glioblastoma multiforme(14;0.00448)|BRCA - Breast invasive adenocarcinoma(182;0.0527)			GATTTTTACCCTAGAAATAAA	0.249000													44	72					0	0	0.111260	0	0
AFP	174	broad.mit.edu	37	4	74303981	74303981	+	Missense_Mutation	SNP	A	C	C			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr4:74303981A>C	uc003hgz.1	+	3	275	c.228A>C	c.(226-228)AAA>AAC	p.K76N	AFP_uc003hha.1_Missense_Mutation_p.K76N	NM_001134	NP_001125	P02771	FETA_HUMAN	alpha-fetoprotein precursor	76	Albumin 1.				transport		metal ion binding			ovary(1)	1	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CAATTGAGAAACCCACTggag	0.209000									Alpha-Fetoprotein_Hereditary_Persistence_of				23	112					0	0	0.062417	0	0
SPZ1	84654	broad.mit.edu	37	5	79616896	79616896	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr5:79616896G>A	uc003kgn.2	+	1	1107	c.862G>A	c.(862-864)GGT>AGT	p.G288S	uc011ctk.1_RNA	NM_032567	NP_115956	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	288					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(1)	1		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		TAATGGAGTCGGTTTCCAAAC	0.413000													68	118					0	0	0.048971	0	0
AQPEP	206338	broad.mit.edu	37	5	115336874	115336874	+	Silent	SNP	C	T	T			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr5:115336874C>T	uc003kro.2	+	10	1922	c.1758C>T	c.(1756-1758)GGC>GGT	p.G586G	AQPEP_uc003krp.2_RNA|AQPEP_uc003krq.2_RNA|AQPEP_uc003krr.2_RNA|AQPEP_uc003krs.2_RNA	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	586	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						TGTCTACTGGCGTCATGAAAC	0.398000													8	266					0	0	0.038147	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475724	140475724	+	Silent	SNP	C	T	T			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr5:140475724C>T	uc003lil.2	+	1	1488	c.1350C>T	c.(1348-1350)GCC>GCT	p.A450A	PCDHB2_uc003lim.1_Silent_p.A111A	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	450	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATGACAACGCCCCCGCCTTCA	0.602000													5	262					0	0	0.038147	0	0
TRIM52	84851	broad.mit.edu	37	5	180687093	180687093	+	Missense_Mutation	SNP	T	C	C			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr5:180687093T>C	uc003mnp.2	-	1	1027	c.722A>G	c.(721-723)GAC>GGC	p.D241G	uc003mnq.2_5'Flank	NM_032765	NP_116154	Q96A61	TRI52_HUMAN	tripartite motif-containing 52	241	B box-type.					intracellular	zinc ion binding				0	all_cancers(89;8.79e-06)|all_epithelial(37;1.13e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0654)	all_cancers(40;0.0106)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0588)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.232)		GGCCTCTTTGTCCACCTCACA	0.542000													107	171					0	0	0.048971	0	0
BRPF3	27154	broad.mit.edu	37	6	36179148	36179148	+	Missense_Mutation	SNP	A	C	C			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr6:36179148A>C	uc003olv.3	+	7	2517	c.2293A>C	c.(2293-2295)ACC>CCC	p.T765P	BRPF3_uc010jwb.2_Intron|BRPF3_uc011dtj.1_Intron|BRPF3_uc010jwc.2_RNA|BRPF3_uc011dtk.1_Intron	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	765					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						TGGGGCCCGCACCCGTCGTGT	0.627000													9	52					0	0	0.030593	0	0
UTRN	7402	broad.mit.edu	37	6	144872125	144872125	+	Missense_Mutation	SNP	C	T	T	rs114254210	byFrequency	TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr6:144872125C>T	uc003qkt.2	+	47	6927	c.6835C>T	c.(6835-6837)CGC>TGC	p.R2279C		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2279	Spectrin 15.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CTTAGAACAGCGCCATCCTCA	0.338000													45	108					0	0	0.039052	0	0
HEATR2	54919	broad.mit.edu	37	7	813720	813720	+	Missense_Mutation	SNP	A	G	G			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr7:813720A>G	uc010krz.1	+	10	1987	c.1967A>G	c.(1966-1968)GAC>GGC	p.D656G	HEATR2_uc003siz.2_Missense_Mutation_p.D524G|HEATR2_uc003sjb.2_Missense_Mutation_p.D36G|HEATR2_uc003sjc.2_Missense_Mutation_p.D81G	NM_017802	NP_060272	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	656							protein binding			skin(1)	1		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		GTGACAAAGGACATCCTGGCC	0.642000													55	151					0	0	0.048971	0	0
COG5	10466	broad.mit.edu	37	7	107002756	107002756	+	Silent	SNP	T	C	C			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr7:107002756T>C	uc003ved.2	-	9	1563	c.1038A>G	c.(1036-1038)GGA>GGG	p.G346G	COG5_uc003vec.2_Silent_p.G346G|COG5_uc003vee.2_Silent_p.G346G	NM_181733	NP_859422	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5 isoform	346					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			central_nervous_system(2)|skin(2)	4						TATTTACCTGTCCACAAACAG	0.289000													12	83					0	0	0.080935	0	0
AGK	55750	broad.mit.edu	37	7	141301025	141301025	+	Missense_Mutation	SNP	A	C	C			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr7:141301025A>C	uc003vwi.2	+	5	413	c.242A>C	c.(241-243)GAA>GCA	p.E81A	AGK_uc011krg.1_RNA	NM_018238	NP_060708	Q53H12	AGK_HUMAN	acylglycerol kinase precursor	81	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	mitochondrial membrane	acylglycerol kinase activity|ATP binding|diacylglycerol kinase activity|NAD+ kinase activity			ovary(1)|breast(1)	2	Melanoma(164;0.0171)					ACTCTATTTGAAAAAAATGCT	0.363000													22	135					0	0	0.083992	0	0
KCNV1	27012	broad.mit.edu	37	8	110984685	110984685	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr8:110984685G>A	uc003ynr.3	-	2	1135	c.793C>T	c.(793-795)CGG>TGG	p.R265W	KCNV1_uc010mcw.2_Missense_Mutation_p.R265W	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	265	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			CACCTGTCCCGCACACACAGG	0.532000													12	172					0	0	0.093190	0	0
C9orf114	51490	broad.mit.edu	37	9	131586077	131586077	+	Missense_Mutation	SNP	G	C	C			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr9:131586077G>C	uc004bwd.2	-	11	1037	c.1011C>G	c.(1009-1011)GAC>GAG	p.D337E	C9orf114_uc004bwe.2_Intron|C9orf114_uc010mym.2_RNA	NM_016390	NP_057474	Q5T280	CI114_HUMAN	hypothetical protein LOC51490	337											0						TGACGTACAGGTCAAAGAGGA	0.642000													4	10					0	0	0.009096	0	0
ZFX	7543	broad.mit.edu	37	X	24229263	24229263	+	Nonsense_Mutation	SNP	C	T	T			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chrX:24229263C>T	uc004dbf.2	+	9	2446	c.2188C>T	c.(2188-2190)CAA>TAA	p.Q730*	ZFX_uc004dbe.2_3'UTR|ZFX_uc011mjv.1_Nonsense_Mutation_p.Q769*|ZFX_uc010nfz.2_Nonsense_Mutation_p.Q386*	NM_003410	NP_003401	P17010	ZFX_HUMAN	zinc finger protein, X-linked	730	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(2)	2						GGGATTTAGGCAACAGAGTGA	0.408000													10	167					0	0	0.069234	0	0
C13orf23	80209	broad.mit.edu	37	13	39585513	39585514	+	Frame_Shift_Ins	INS	-	T	T			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr13:39585513_39585514insT	uc001uwy.2	-	13	3696_3697	c.2823_2824insA	c.(2821-2826)AGTGGGfs	p.S941fs	C13orf23_uc001uwz.2_Frame_Shift_Ins_p.S919fs	NM_025138	NP_079414	Q86XN7	CM023_HUMAN	hypothetical protein LOC80209 isoform 1	941_942										ovary(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)	5		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;3.7e-08)|Epithelial(112;4.28e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00114)|BRCA - Breast invasive adenocarcinoma(63;0.00366)|GBM - Glioblastoma multiforme(144;0.0146)		CACTGCCACCCACTCTGGGACA	0.460													12	182	---	---	---	---					
ADAM6	8755	broad.mit.edu	37	14	106725136	106725137	+	RNA	INS	-	C	C			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr14:106725136_106725137insC	uc010tyt.1	-	589		c.18377_18378insG								Parts of antibodies, mostly variable regions.												0						GCCGCTGATTTCCCCCCCATCG	0.584													21	115	---	---	---	---					
TCERG1	10915	broad.mit.edu	37	5	145886722	145886723	+	Frame_Shift_Ins	INS	-	A	A			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chr5:145886722_145886723insA	uc003lob.2	+	19	2902_2903	c.2862_2863insA	c.(2860-2865)ACCAAAfs	p.T954fs	TCERG1_uc003loc.2_Frame_Shift_Ins_p.T933fs	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	954_955					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGCACTTACCAAAAAAAAGAG	0.376													7	247	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76939929	76939930	+	Frame_Shift_Ins	INS	-	A	A			TCGA-E1-5303-01A-01D-1468-08	TCGA-E1-5303-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4fecec7-4ee8-4b07-be22-6f816260f0b0	8f5ce4b8-2c8d-4411-b159-0035f461c34b	g.chrX:76939929_76939930insA	uc004ecp.3	-	9	1050_1051	c.818_819insT	c.(817-819)TTGfs	p.L273fs	ATRX_uc004ecq.3_Frame_Shift_Ins_p.L235fs|ATRX_uc004eco.3_Frame_Shift_Ins_p.L58fs|ATRX_uc004ecr.2_Frame_Shift_Ins_p.L234fs|ATRX_uc010nlx.1_Frame_Shift_Ins_p.L273fs|ATRX_uc010nly.1_Frame_Shift_Ins_p.L218fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	273	ADD.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	CCAAGTCCAACAAAGGCTCTGG	0.381			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						232	122	---	---	---	---					
