Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HRNR	388697	broad.mit.edu	37	1	152193228	152193228	+	Missense_Mutation	SNP	A	G	G			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr1:152193228A>G	uc001ezt.1	-	3	953	c.877T>C	c.(877-879)TCT>CCT	p.S293P		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	293	3.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGCCCAAAGACTGACGGGAA	0.607000													13	301					0	0	0.500413	0	0
SELE	6401	broad.mit.edu	37	1	169698637	169698637	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr1:169698637G>A	uc001ggm.3	-	6	1050	c.893C>T	c.(892-894)ACG>ATG	p.T298M	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	298	Sushi 2.|Extracellular (Potential).				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					ACCTTTACACGTTGGCTTCTC	0.443000													80	93					0	0	0.870114	0	0
LOC729020	729020	broad.mit.edu	37	10	105005791	105005791	+	Missense_Mutation	SNP	A	G	G			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr10:105005791A>G	uc009xxi.2	+	1	148	c.38A>G	c.(37-39)AAC>AGC	p.N13S	uc001kwr.2_Intron	NM_001143909	NP_001137381	Q2QD12	Q2QD12_HUMAN	rcRPE protein	13					carbohydrate metabolic process		ribulose-phosphate 3-epimerase activity				0						TCCATCCTCAACAGCGACCTG	0.552000													53	69					0	0	0.870114	0	0
KNDC1	85442	broad.mit.edu	37	10	135038195	135038195	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr10:135038195C>T	uc001llz.1	+	30	5052	c.5051C>T	c.(5050-5052)GCG>GTG	p.A1684V		NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1684	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		CAGGTGCACGCGTTCCAGGAG	0.597000													23	51					0	0	0.639603	0	0
OR52B6	340980	broad.mit.edu	37	11	5602864	5602864	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr11:5602864G>A	uc010qzi.1	+	1	758	c.758G>A	c.(757-759)CGC>CAC	p.R253H	HBG2_uc001mak.1_Intron	NM_001005162	NP_001005162	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B,	253	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAAGATGCCCGCTCCAAGGCC	0.507000													37	307					0	0	0.827153	0	0
OR4D10	390197	broad.mit.edu	37	11	59245574	59245574	+	Missense_Mutation	SNP	A	T	T			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr11:59245574A>T	uc001nnz.1	+	1	672	c.672A>T	c.(670-672)TTA>TTT	p.L224F		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	224	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						TATTATCATTACCCAAGTCTC	0.478000													5	160					0	0	0.184627	0	0
AHNAK	79026	broad.mit.edu	37	11	62299210	62299210	+	Silent	SNP	C	T	T			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr11:62299210C>T	uc001ntl.2	-	5	2979	c.2679G>A	c.(2677-2679)GAG>GAA	p.E893E	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	893					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CTTCTGGGCCCTCTGCTTTGA	0.517000													256	310					0	0	0.870114	0	0
CWF19L2	143884	broad.mit.edu	37	11	107224323	107224323	+	Missense_Mutation	SNP	T	C	C			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr11:107224323T>C	uc010rvp.1	-	13	2042	c.2012A>G	c.(2011-2013)CAA>CGA	p.Q671R	CWF19L2_uc001pjh.3_RNA|CWF19L2_uc009yxo.2_RNA	NM_152434	NP_689647	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control	671	Potential.						catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		TTTTTCCATTTGTGCAGCAAG	0.393000													50	75					0	0	0.870114	0	0
HTR7P1	93164	broad.mit.edu	37	12	13155006	13155006	+	RNA	SNP	G	C	C			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr12:13155006G>C	uc010shq.1	+	1		c.1631G>C			HEBP1_uc001rbd.2_5'Flank|HEBP1_uc001rbf.2_5'Flank|HTR7P1_uc001rbh.2_Intron	NR_002774				Homo sapiens 5-hydroxytryptamine (serotonin) receptor 7 pseudogene (HTR7P), non-coding RNA.												0						CGTACCCTATGAGGCAGAAGG	0.483000													4	14					0	0	0.150653	0	0
KSR2	283455	broad.mit.edu	37	12	118016978	118016978	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr12:118016978G>A	uc001two.2	-	7	1239	c.1184C>T	c.(1183-1185)ACG>ATG	p.T395M		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	424	Phorbol-ester/DAG-type.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GACTGTGCACGTCTGAGACAT	0.468000													7	41					0	0	0.248553	0	0
IL31	386653	broad.mit.edu	37	12	122658748	122658748	+	Splice_Site	SNP	G	T	T			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr12:122658748G>T	uc001ubv.2	-	1	1	c.-26_splice	c.e1-1		LRRC43_uc001ubw.3_Intron|LRRC43_uc009zxl.1_Intron	NM_001014336	NP_001014358	Q6EBC2	IL31_HUMAN	interleukin 31 precursor							extracellular space	cytokine activity			central_nervous_system(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;6.93e-05)|Breast(359;0.0544)		OV - Ovarian serous cystadenocarcinoma(86;3.27e-29)|Epithelial(86;4.86e-27)|BRCA - Breast invasive adenocarcinoma(302;0.223)		CAGCTTCAGTGGGGGCTTCTG	0.572000													33	27					1.61788e-16	1.8336e-16	0.760397	1	0
EP400	57634	broad.mit.edu	37	12	132547093	132547093	+	Silent	SNP	A	G	G	rs28513925	by1000genomes	TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr12:132547093A>G	uc001ujn.2	+	46	8216	c.8181A>G	c.(8179-8181)CAA>CAG	p.Q2727Q	EP400_uc001ujl.2_Silent_p.Q2726Q|EP400_uc001ujm.2_Silent_p.Q2646Q|EP400_uc001ujp.2_5'UTR	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2763	Poly-Gln.|Interaction with ZNF42 (By similarity).				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcaacaacagcagcagc	0.294000													4	5					0	0	0.150653	0	0
LMO7	4008	broad.mit.edu	37	13	76382215	76382215	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr13:76382215G>A	uc001vjv.2	+	7	1857	c.1097G>A	c.(1096-1098)GGA>GAA	p.G366E	LMO7_uc010thv.1_Intron|LMO7_uc001vjt.1_Intron|LMO7_uc010thw.1_Intron|LMO7_uc001vjw.1_Missense_Mutation_p.G272E	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	651						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		TGGAAACTGGGAACTACCGTG	0.498000													25	54					0	0	0.654019	0	0
CYP1A1	1543	broad.mit.edu	37	15	75012968	75012968	+	Silent	SNP	G	C	C			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr15:75012968G>C	uc002ayp.3	-	7	1523	c.1401C>G	c.(1399-1401)GTC>GTG	p.V467V	CYP1A1_uc010bjv.2_RNA|CYP1A1_uc010bjw.2_RNA|CYP1A1_uc010bju.2_Silent_p.V203V|CYP1A1_uc010bjx.2_Silent_p.V203V|CYP1A1_uc002ayq.3_Silent_p.V467V|CYP1A1_uc010bjy.2_Silent_p.V438V	NM_000499	NP_000490	P04798	CP1A1_HUMAN	cytochrome P450, family 1, subfamily A,	467					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity			ovary(2)|breast(2)|pancreas(1)	5					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	GGAAGAGAAAGACCTCCCAGC	0.542000									Endometrial_Cancer_Familial_Clustering_of|ACTH-independent_macronodular_adrenal_hyperplasia				35	138					0	0	0.769981	0	0
IDH2	3418	broad.mit.edu	37	15	90631838	90631838	+	Missense_Mutation	SNP	C	A	A	rs121913503		TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr15:90631838C>A	uc002box.2	-	4	601	c.515G>T	c.(514-516)AGG>ATG	p.R172M	IDH2_uc010uqb.1_Missense_Mutation_p.R120M|IDH2_uc010uqc.1_Missense_Mutation_p.R42M|IDH2_uc010bnu.2_Intron	NM_002168	NP_002159	P48735	IDHP_HUMAN	isocitrate dehydrogenase 2 (NADP+),	172		Substrate (By similarity).			2-oxoglutarate metabolic process|glyoxylate cycle|isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding	p.R172K(170)|p.R172M(21)|p.R172S(12)|p.R172W(7)|p.R172?(7)|p.R172G(2)		haematopoietic_and_lymphoid_tissue(621)|central_nervous_system(80)|bone(7)|skin(3)	711	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.106)			ATGGGCGTGCCTGCCAATGGT	0.632000			M		GBM								63	76					7.05995e-25	8.27719e-25	0.870114	1	0
Unknown	0	broad.mit.edu	37	15	102288086	102288086	+	Silent	SNP	G	A	A			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr15:102288086G>A	uc010usj.1	+	2	104	c.45G>A	c.(43-45)GTG>GTA	p.V15V						RecName: Full=Uncharacterized protein C15orf51.; Flags: Fragment;																		GTGGAGGAGTGAGAAATGTTA	0.458000													33	50					0	0	0.870114	0	0
CDH5	1003	broad.mit.edu	37	16	66436644	66436644	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr16:66436644G>A	uc002eom.3	+	12	2083	c.1927G>A	c.(1927-1929)GTC>ATC	p.V643I		NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	643	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		CGAGCAGCTGGTCACCTACGA	0.572000													5	16					0	0	0.217242	0	0
KRT33B	3884	broad.mit.edu	37	17	39521763	39521763	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr17:39521763C>T	uc002hwl.2	-	4	676	c.631G>A	c.(631-633)GTG>ATG	p.V211M		NM_002279	NP_002270	Q14525	KT33B_HUMAN	type I hair keratin 3B	211	Linker 12.|Rod.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				TCCACCTCCACGTTGAGGCGG	0.522000													26	35					0	0	0.681144	0	0
EMILIN2	84034	broad.mit.edu	37	18	2913224	2913224	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr18:2913224C>T	uc002kln.2	+	8	3143	c.2984C>T	c.(2983-2985)CCT>CTT	p.P995L		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	995	C1q.				cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		TACCACCGCCCTCCAGGAGCT	0.632000													4	75					0	0	0.150653	0	0
ELL	8178	broad.mit.edu	37	19	18557617	18557617	+	Silent	SNP	G	A	A	rs73923115	byFrequency	TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr19:18557617G>A	uc002njh.2	-	9	1545	c.1473C>T	c.(1471-1473)AAC>AAT	p.N491N	ELL_uc010ebq.2_Silent_p.N434N|ELL_uc002njg.2_Silent_p.N358N	NM_006532	NP_006523	P55199	ELL_HUMAN	elongation factor RNA polymerase II	491					positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	Cajal body|nuclear speck|transcription elongation factor complex	protein binding			lung(1)	1				GBM - Glioblastoma multiforme(1328;7.81e-07)		TGCAGGTTCCGTTTAAACCTA	0.572000			T	MLL	AL								13	50					0	0	0.411799	0	0
PRODH2	58510	broad.mit.edu	37	19	36302867	36302867	+	Silent	SNP	C	T	T			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr19:36302867C>T	uc002obx.1	-	5	840	c.822G>A	c.(820-822)GGG>GGA	p.G274G		NM_021232	NP_067055	Q9UF12	PROD2_HUMAN	kidney and liver proline oxidase 1	274					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			ovary(2)	2	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCCTTACCTGCCCAGAGTCCA	0.597000													23	13					0	0	0.624587	0	0
KLK4	9622	broad.mit.edu	37	19	51411835	51411835	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr19:51411835C>T	uc002pua.1	-	3	475	c.475G>A	c.(475-477)GGC>AGC	p.G159S	KLK4_uc002pty.1_Missense_Mutation_p.G110R|KLK4_uc002ptz.1_RNA|KLK4_uc002pub.1_Missense_Mutation_p.G64S|KLK4_uc002puc.1_RNA|KLK4_uc010eoi.1_Missense_Mutation_p.G64S|KLK4_uc002pud.1_Missense_Mutation_p.G64S	NM_004917	NP_004908	Q9Y5K2	KLK4_HUMAN	kallikrein-related peptidase 4 preproprotein	159	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00624)|GBM - Glioblastoma multiforme(134;0.00878)		GTGAGCTCACCGTTCGCCAGC	0.637000													8	75					0	0	0.307466	0	0
MIR498	574460	broad.mit.edu	37	19	54177516	54177516	+	RNA	SNP	A	G	G			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr19:54177516A>G	hsa-mir-498|MI0003142	+			c.66A>G			MIR520E_hsa-mir-520e|MI0003143_5'Flank																	0						CTATAACTGGATGAAAAGCAC	0.443000													86	21					0	0	0.870114	0	0
INO80B	83444	broad.mit.edu	37	2	74684817	74684817	+	Silent	SNP	G	A	A			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr2:74684817G>A	uc002slg.2	+	5	942	c.897G>A	c.(895-897)CGG>CGA	p.R299R	INO80B_uc002slf.1_3'UTR|INO80B_uc010yrr.1_Silent_p.R271R|WBP1_uc002slh.1_Intron|INO80B_uc002sli.1_RNA|INO80B_uc010yrs.1_Silent_p.R317R|WBP1_uc002slj.1_5'Flank|WBP1_uc002slk.1_5'Flank|WBP1_uc002sll.1_5'Flank	NM_031288	NP_112578	Q9C086	IN80B_HUMAN	high mobility group AT-hook 1-like 4	299					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex|nucleolus	metal ion binding|protein binding			pancreas(1)	1						TGTCTCAGCGGCCATCCCCCT	0.642000													3	36					0	0	0.115264	0	0
ANKRD20B	729171	broad.mit.edu	37	2	95472217	95472217	+	Splice_Site	SNP	T	C	C			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr2:95472217T>C	uc010fhp.2	-	16		c.2502_splice	c.e16-1			NR_003366				Homo sapiens ankyrin repeat domain 20B (ANKRD20B), non-coding RNA.												0						TTCTTATATCTGCAGAAATGT	0.269000													28	36					0	0	0.681144	0	0
IL1RL2	8808	broad.mit.edu	37	2	102805614	102805614	+	Missense_Mutation	SNP	C	A	A			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr2:102805614C>A	uc002tbs.2	+	3	263	c.137C>A	c.(136-138)CCC>CAC	p.P46H	IL1RL2_uc002tbt.2_Intron	NM_003854	NP_003845	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2 precursor	46	Extracellular (Potential).|Ig-like C2-type 1.				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			ovary(2)	2						ACATTCCCTCCCATAACATCT	0.378000													9	144					0.00621372	0.0065005	0.335167	1	0
NEB	4703	broad.mit.edu	37	2	152521900	152521900	+	Missense_Mutation	SNP	T	A	A			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr2:152521900T>A	uc010fnx.2	-	42	5376	c.5185A>T	c.(5185-5187)ATG>TTG	p.M1729L		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	1729	Nebulin 45.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		ATTGTGTCCATGGCGTAAGTG	0.507000													30	38					0	0	0.750413	0	0
KLHL30	377007	broad.mit.edu	37	2	239051515	239051515	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr2:239051515G>A	uc002vxr.1	+	2	829	c.796G>A	c.(796-798)GCA>ACA	p.A266T		NM_198582	NP_940984	Q0D2K2	KLH30_HUMAN	kelch-like 30	284	Kelch 1.										0		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		GGAGGAGGAGGCAGGTGAGGA	0.672000													4	15					0	0	0.248553	0	0
TPTE	7179	broad.mit.edu	37	21	11014937	11014937	+	Splice_Site	SNP	C	T	T	rs76467559	by1000genomes	TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr21:11014937C>T	uc002yis.1	-	7		c.1508_splice	c.e7+1					P56180	TPTE_HUMAN	Homo sapiens putative tyrosine phosphatase mRNA, complete cds.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CAGCACAATACCTATCACATT	0.328000													4	8					0	0	0.184627	0	0
BRWD1	54014	broad.mit.edu	37	21	40590181	40590181	+	Missense_Mutation	SNP	C	T	T	rs75547980		TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr21:40590181C>T	uc002yxk.1	-	31	3695	c.3556G>A	c.(3556-3558)GCA>ACA	p.A1186T	BRWD1_uc010goc.1_Intron|BRWD1_uc002yxl.2_Missense_Mutation_p.A1186T|BRWD1_uc010god.1_Missense_Mutation_p.A152T	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1186	Bromo 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				ACAGGGCCTGCAAAAGCTGCT	0.368000													23	136					0	0	0.639603	0	0
SI	6476	broad.mit.edu	37	3	164776970	164776970	+	Missense_Mutation	SNP	A	G	G	rs148511215	by1000genomes	TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr3:164776970A>G	uc003fei.2	-	11	1326	c.1264T>C	c.(1264-1266)TAT>CAT	p.Y422H		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	422	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ATGATGACATATTTCTGTCCA	0.323000										HNSCC(35;0.089)			13	94					0	0	0.500413	0	0
ATP13A3	79572	broad.mit.edu	37	3	194170983	194170983	+	Silent	SNP	G	A	A			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr3:194170983G>A	uc003fty.3	-	10	1263	c.861C>T	c.(859-861)ACC>ACT	p.T287T	ATP13A3_uc003ftz.1_5'UTR	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	287					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		GCACAAGGTCGGTAGAAAAGA	0.343000													4	83					0	0	0.150653	0	0
MUC4	4585	broad.mit.edu	37	3	195505849	195505849	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr3:195505849G>A	uc011bto.1	-	3	12678	c.12218C>T	c.(12217-12219)GCA>GTA	p.A4073V	MUC4_uc003fva.2_5'Flank|MUC4_uc003fvb.2_5'Flank|MUC4_uc003fvc.2_5'Flank|MUC4_uc003fvd.2_5'Flank|MUC4_uc003fve.2_5'Flank|MUC4_uc010hzr.2_5'Flank|MUC4_uc011btf.1_Intron|MUC4_uc011btg.1_Intron|MUC4_uc011bth.1_Intron|MUC4_uc011bti.1_Intron|MUC4_uc011btj.1_Intron|MUC4_uc011btk.1_Intron|MUC4_uc011btl.1_Intron|MUC4_uc011btm.1_Intron|MUC4_uc011btn.1_Intron|MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		ACCTGTGGATGCTGAGGAAGT	0.592000													5	5					0	0	0.278610	0	0
FSTL5	56884	broad.mit.edu	37	4	162577528	162577528	+	Nonsense_Mutation	SNP	C	T	T			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr4:162577528C>T	uc003iqh.2	-	7	1282	c.846G>A	c.(844-846)TGG>TGA	p.W282*	FSTL5_uc003iqi.2_Nonsense_Mutation_p.W281*|FSTL5_uc010iqv.2_Nonsense_Mutation_p.W281*	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	282	Ig-like 1.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TGTTCCTTTTCCAGATAATGG	0.353000													18	97					0	0	0.539581	0	0
NAIP	4671	broad.mit.edu	37	5	70308387	70308387	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr5:70308387C>T	uc003kar.1	-	4	1074	c.356G>A	c.(355-357)AGG>AAG	p.R119K	NAIP_uc003kat.1_Intron|NAIP_uc011crs.1_Missense_Mutation_p.R119K|NAIP_uc003kas.1_Intron	NM_004536	NP_004527	Q13075	BIRC1_HUMAN	NLR family, apoptosis inhibitory protein isoform	119	BIR 1.				anti-apoptosis|apoptosis|nervous system development	basolateral plasma membrane|cytoplasm	caspase inhibitor activity|metal ion binding|nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(1)	1		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		TGGATGAAACCTCTTGTGGTC	0.473000													63	97					0	0	0.870114	0	0
Unknown	0	broad.mit.edu	37	5	79655242	79655242	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr5:79655242C>T	uc003kgo.2	-	1	666	c.503G>A	c.(502-504)CGT>CAT	p.R168H						SubName: Full=Putative uncharacterized protein; Flags: Fragment;																		accacctccacgaccaccacc	0.214000													3	69					0	0	0.115264	0	0
LYPLA2P1	653639	broad.mit.edu	37	6	33333333	33333333	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr6:33333333G>A	uc003shx.2	-	1	807	c.673C>T	c.(673-675)CCT>TCT	p.P225S		NR_001444				SubName: Full=Lysophospholipase II; Flags: Fragment;												0						AGTTAGACAGGAGGCAGCAGC	0.577000													4	39					0	0	0.150653	0	0
LYPLA2P1	653639	broad.mit.edu	37	6	33333342	33333342	+	Silent	SNP	G	A	A	rs140475230	by1000genomes	TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr6:33333342G>A	uc003shx.2	-	1	798	c.664C>T	c.(664-666)CTG>TTG	p.L222L		NR_001444				SubName: Full=Lysophospholipase II; Flags: Fragment;												0						GGAGGCAGCAGCTTCTCAAGA	0.562000													4	42					0	0	0.150653	0	0
TTK	7272	broad.mit.edu	37	6	80746270	80746270	+	Missense_Mutation	SNP	C	A	A			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr6:80746270C>A	uc003pjc.2	+	17	2077	c.2003C>A	c.(2002-2004)GCA>GAA	p.A668E	TTK_uc003pjb.3_Missense_Mutation_p.A667E	NM_003318	NP_003309	P33981	TTK_HUMAN	TTK protein kinase	668	Protein kinase.				mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(4)|stomach(2)|lung(2)|large_intestine(2)|pancreas(1)	11		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		TTTGGGATTGCAAACCAAATG	0.338000													7	186					0.00198382	0.00210781	0.248553	1	0
PSD3	23362	broad.mit.edu	37	8	18725224	18725224	+	Missense_Mutation	SNP	T	C	C	rs62636654		TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr8:18725224T>C	uc003wza.2	-	4	1697	c.1594A>G	c.(1594-1596)ATC>GTC	p.I532V		NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	532					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		TTCGTGTAGATGGAGTCGCTG	0.507000													71	103					0	0	0.870114	0	0
KCNU1	157855	broad.mit.edu	37	8	36671795	36671795	+	Missense_Mutation	SNP	A	G	G			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr8:36671795A>G	uc010lvw.2	+	8	890	c.803A>G	c.(802-804)TAC>TGC	p.Y268C	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	268						voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		GAGTCAATTTACCTGGTCATG	0.433000													8	61					0	0	0.278610	0	0
KLHL9	55958	broad.mit.edu	37	9	21333865	21333865	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr9:21333865G>A	uc003zoy.2	-	1	1565	c.994C>T	c.(994-996)CCA>TCA	p.P332S	KLHL9_uc003zow.2_Intron|KLHL9_uc003zox.2_RNA	NM_018847	NP_061335	Q9P2J3	KLHL9_HUMAN	kelch-like 9	332	Kelch 1.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|midbody				ovary(3)|skin(1)	4				Lung(24;8.52e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.118)		GCATCCATTGGGGCTAAAGAT	0.418000													84	133					0	0	0.870114	0	0
SIT1	27240	broad.mit.edu	37	9	35650242	35650242	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr9:35650242C>T	uc003zxe.1	-	4	393	c.296G>A	c.(295-297)GGA>GAA	p.G99E	SIT1_uc003zxf.1_RNA	NM_014450	NP_055265	Q9Y3P8	SIT1_HUMAN	SHP2-interacting transmembrane adaptor protein	99	Cytoplasmic (Potential).				regulation of T cell activation|signal transduction	integral to plasma membrane	kinase binding|SH2 domain binding				0			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			AGACAGCCGTCCTGGGACGGG	0.627000													52	75					0	0	0.870114	0	0
CIZ1	25792	broad.mit.edu	37	9	130952718	130952718	+	Missense_Mutation	SNP	A	G	G			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr9:130952718A>G	uc004btt.2	-	3	339	c.176T>C	c.(175-177)CTC>CCC	p.L59P	CIZ1_uc004btr.2_Missense_Mutation_p.L59P|CIZ1_uc004bts.2_Missense_Mutation_p.L59P|CIZ1_uc011maq.1_Missense_Mutation_p.L59P|CIZ1_uc004btu.2_Missense_Mutation_p.L59P|CIZ1_uc011mar.1_Intron|CIZ1_uc011mas.1_Missense_Mutation_p.L89P|CIZ1_uc004btw.2_Missense_Mutation_p.L59P|CIZ1_uc004btv.2_Missense_Mutation_p.L59P|CIZ1_uc004btx.2_Missense_Mutation_p.L59P	NM_001131016	NP_001124488	Q9ULV3	CIZ1_HUMAN	CDKN1A interacting zinc finger protein 1 isoform	59						nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4						CTGCGGGGGGAGCCCCCTGTG	0.582000													5	26					0	0	0.217242	0	0
ARSE	415	broad.mit.edu	37	X	2867631	2867631	+	Missense_Mutation	SNP	G	A	A			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chrX:2867631G>A	uc004crc.3	-	6	818	c.568C>T	c.(568-570)CGT>TGT	p.R190C	ARSE_uc011mhi.1_Missense_Mutation_p.R136C|ARSE_uc011mhh.1_Missense_Mutation_p.R215C	NM_000047	NP_000038	P51690	ARSE_HUMAN	arylsulfatase E precursor	190					skeletal system development	Golgi stack	arylsulfatase activity|metal ion binding			ovary(1)|central_nervous_system(1)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AGGTTGACACGCTTCTCTGAG	0.527000													7	70					0	0	0.307466	0	0
PDHA1	5160	broad.mit.edu	37	X	19368118	19368118	+	Missense_Mutation	SNP	G	C	C			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chrX:19368118G>C	uc004czg.3	+	3	326	c.181G>C	c.(181-183)GGG>CGG	p.G61R	PDHA1_uc004czh.3_Missense_Mutation_p.G96R|PDHA1_uc011mjc.1_Missense_Mutation_p.G58R|PDHA1_uc011mjd.1_Missense_Mutation_p.G58R|PDHA1_uc010nfk.2_Missense_Mutation_p.G58R	NM_000284	NP_000275	P08559	ODPA_HUMAN	pyruvate dehydrogenase E1 alpha 1 precursor	61					glycolysis|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	protein binding|pyruvate dehydrogenase (acetyl-transferring) activity			ovary(1)	1	Hepatocellular(33;0.183)				NADH(DB00157)	CAGGGAGGATGGGCTCAAATA	0.453000													74	95					0	0	0.870114	0	0
MAGEB2	4113	broad.mit.edu	37	X	30237371	30237371	+	Missense_Mutation	SNP	A	T	T			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chrX:30237371A>T	uc004dbz.2	+	2	777	c.674A>T	c.(673-675)GAA>GTA	p.E225V		NM_002364	NP_002355	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	225	MAGE.						protein binding			ovary(1)	1						GAGATCTGGGAATTCCTGAAT	0.483000													14	59					0	0	0.435327	0	0
NLGN3	54413	broad.mit.edu	37	X	70387552	70387552	+	Missense_Mutation	SNP	G	T	T			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chrX:70387552G>T	uc004dzd.1	+	6	1805	c.1605G>T	c.(1603-1605)ATG>ATT	p.M535I	NLGN3_uc010nlb.1_Missense_Mutation_p.M495I|NLGN3_uc004dzb.2_Missense_Mutation_p.M515I|NLGN3_uc004dzc.2_Missense_Mutation_p.M398I|NLGN3_uc011mps.1_Missense_Mutation_p.M495I|NLGN3_uc004dze.2_Missense_Mutation_p.M333I	NM_018977	NP_061850	Q9NZ94	NLGN3_HUMAN	neuroligin 3	535	Extracellular (Potential).				neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			ovary(1)	1	Renal(35;0.156)					GGGTTCCTATGGTAGGCCCCA	0.498000													11	269					1.08611e-07	1.21074e-07	0.387290	1	0
ATP7A	538	broad.mit.edu	37	X	77301816	77301816	+	Missense_Mutation	SNP	T	G	G			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chrX:77301816T>G	uc004ecx.3	+	23	4412	c.4252T>G	c.(4252-4254)TAT>GAT	p.Y1418D		NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	1418	Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						TTACGAGAGTTATGAACTGCC	0.413000													15	343					0	0	0.457914	0	0
PGRMC1	10857	broad.mit.edu	37	X	118370561	118370561	+	Missense_Mutation	SNP	C	T	T			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chrX:118370561C>T	uc004erb.2	+	1	351	c.235C>T	c.(235-237)CGG>TGG	p.R79W	PGRMC1_uc011mts.1_Missense_Mutation_p.R79W	NM_006667	NP_006658	O00264	PGRC1_HUMAN	progesterone receptor membrane component 1	79	Cytochrome b5 heme-binding.|Cytoplasmic (Potential).					cell surface|endoplasmic reticulum membrane|integral to membrane|microsome|nucleolus	heme binding|protein binding|receptor activity|steroid binding				0						CGCCGAGCTGCGGCGCTTCGA	0.711000													10	20					0	0	0.479597	0	0
LAMP2	3920	broad.mit.edu	37	X	119581704	119581704	+	Nonsense_Mutation	SNP	G	A	A			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chrX:119581704G>A	uc004est.3	-	5	913	c.733C>T	c.(733-735)CAG>TAG	p.Q245*	LAMP2_uc004ess.3_Nonsense_Mutation_p.Q245*|LAMP2_uc011mtz.1_Nonsense_Mutation_p.Q134*|LAMP2_uc011mua.1_Nonsense_Mutation_p.Q198*|LAMP2_uc010nqp.1_Nonsense_Mutation_p.Q245*	NM_002294	NP_002285	P13473	LAMP2_HUMAN	lysosomal-associated membrane protein 2 isoform	245	Lumenal (Potential).|Second lumenal domain.				platelet activation|platelet degranulation	endosome membrane|integral to membrane|late endosome|lysosomal membrane|membrane fraction|plasma membrane|platelet dense granule membrane				ovary(1)	1						ACCTTATCCTGAGTGATGTTC	0.403000													19	238					0	0	0.539581	0	0
CIC	23152	broad.mit.edu	37	19	42795241	42795242	+	Frame_Shift_Ins	INS	-	GCCCCCT	GCCCCCT			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr19:42795241_42795242insGCCCCCT	uc002otf.1	+	10	2361_2362	c.2321_2322insGCCCCCT	c.(2320-2322)GCGfs	p.A774fs		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	774	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				GGGGCCCCTGCGCCCCCTGCTG	0.698			T	DUX4	soft tissue sarcoma								10	31	---	---	---	---					
CRIPAK	285464	broad.mit.edu	37	4	1388441	1388442	+	Frame_Shift_Ins	INS	-	CG	CG	rs144787346	byFrequency	TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chr4:1388441_1388442insCG	uc003gdf.2	+	1	3102_3103	c.142_143insCG	c.(142-144)ATGfs	p.M48fs		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	48	1.				ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			CTGCTCACACATGCCCATGTGG	0.644													9	691	---	---	---	---					
BCOR	54880	broad.mit.edu	37	X	39933875	39933875	+	Frame_Shift_Del	DEL	C	-	-			TCGA-E1-5318-01A-01D-1468-08	TCGA-E1-5318-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c46a1df-1c10-4188-992a-a55b782494c9	0fce50b4-028d-4b54-aa49-3a8e28a7f7c6	g.chrX:39933875delC	uc004den.3	-	4	1016	c.724delG	c.(724-726)GAGfs	p.E242fs	BCOR_uc004dep.3_Frame_Shift_Del_p.E242fs|BCOR_uc004deo.3_Frame_Shift_Del_p.E242fs|BCOR_uc004dem.3_Frame_Shift_Del_p.E242fs|BCOR_uc004deq.3_Frame_Shift_Del_p.E242fs	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	242					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						AGAAAGCGCTCCCCATTGGTG	0.577													42	68	---	---	---	---					
