Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PM20D1	148811	broad.mit.edu	37	1	205814452	205814452	+	Splice_Site	SNP	C	G	G			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr1:205814452C>G	uc001hdj.2	-	3	534	c.489_splice	c.e3+1	p.M163_splice	PM20D1_uc009xbr.2_Splice_Site	NM_152491	NP_689704	Q6GTS8	P20D1_HUMAN	peptidase M20 domain containing 1 precursor							extracellular region	metal ion binding|peptidase activity			skin(1)	1	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			GCATCTCAGACCATCACAGAG	0.547000													4	62					0	0	0.184627	0	0
CCDC88B	283234	broad.mit.edu	37	11	64120928	64120928	+	Missense_Mutation	SNP	G	C	C			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr11:64120928G>C	uc001nzy.2	+	22	3837	c.3793G>C	c.(3793-3795)GAG>CAG	p.E1265Q	CCDC88B_uc009ypo.1_Missense_Mutation_p.E1262Q|CCDC88B_uc001oaa.2_Missense_Mutation_p.E417Q|CCDC88B_uc001oab.1_Missense_Mutation_p.E96Q|CCDC88B_uc001oac.2_5'UTR	NM_032251	NP_115627	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88	1265	Potential.				microtubule cytoskeleton organization	cytoplasm	microtubule binding			ovary(3)|skin(1)	4						GCGCAGCCTGGAGAGTCGGGA	0.677000													7	16					0	0	0.248553	0	0
GUCY2C	2984	broad.mit.edu	37	12	14794127	14794127	+	Missense_Mutation	SNP	G	A	A	rs148314105		TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr12:14794127G>A	uc001rcd.2	-	18	2094	c.1957C>T	c.(1957-1959)CGC>TGC	p.R653C		NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	653	Cytoplasmic (Potential).|Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						TTGGCTTGGCGGAGGTGCTCT	0.498000													17	55					0	0	0.539581	0	0
AQP2	359	broad.mit.edu	37	12	50344816	50344816	+	Missense_Mutation	SNP	A	C	C	rs104894331		TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr12:50344816A>C	uc001rvn.2	+	1	293	c.203A>C	c.(202-204)AAC>ACC	p.N68T		NM_000486	NP_000477	P41181	AQP2_HUMAN	aquaporin 2	68	Cytoplasmic (Potential).|NPA 1.		N -> S (in ANDI).		cellular response to copper ion|cellular response to mercury ion|excretion	apical plasma membrane|integral to membrane|transport vesicle membrane	glycerol transmembrane transporter activity|water channel activity			ovary(2)	2						GCCCACATCAACCCTGCCGTG	0.662000													6	22					0	0	0.520397	0	0
TXNDC16	57544	broad.mit.edu	37	14	52922041	52922041	+	Splice_Site	SNP	C	T	T			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr14:52922041C>T	uc001wzs.2	-	18	2291	c.1842_splice	c.e18+1	p.F614_splice	TXNDC16_uc010tqu.1_Splice_Site_p.F609_splice|TXNDC16_uc010aoe.2_Splice_Site	NM_020784	NP_065835	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16 isoform 1						cell redox homeostasis	extracellular region					0	Breast(41;0.0716)					AACATACTCACAAACATTTCC	0.358000													13	39					0	0	0.479597	0	0
CAPN3	825	broad.mit.edu	37	15	42676717	42676717	+	Missense_Mutation	SNP	G	T	T			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr15:42676717G>T	uc001zpn.1	+	2	652	c.346G>T	c.(346-348)GCC>TCC	p.A116S	CAPN3_uc001zpk.1_5'UTR|CAPN3_uc001zpl.1_Missense_Mutation_p.A29S|CAPN3_uc010udf.1_Missense_Mutation_p.A29S|CAPN3_uc010udg.1_Missense_Mutation_p.A29S|CAPN3_uc001zpo.1_Missense_Mutation_p.A116S|CAPN3_uc001zpp.1_Missense_Mutation_p.A116S	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	116	Calpain catalytic.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		CATTGATGGAGCCAACAGAAC	0.393000													23	85					0.000147802	0.00015947	0.706142	1	0
IGF1R	3480	broad.mit.edu	37	15	99434555	99434555	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr15:99434555G>A	uc002bul.2	+	3	692	c.642G>A	c.(640-642)ATG>ATA	p.M214I	IGF1R_uc010urq.1_Missense_Mutation_p.M214I|IGF1R_uc010bon.2_Missense_Mutation_p.M214I	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	214					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	TCTCCACAGTGTGCCCAAGCA	0.647000													6	10					0	0	0.278610	0	0
CDK10	8558	broad.mit.edu	37	16	89753130	89753130	+	Silent	SNP	A	T	T			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr16:89753130A>T	uc010cio.2	+	1	55	c.12A>T	c.(10-12)CCA>CCT	p.P4P	uc002fnz.3_5'Flank|CDK10_uc002foa.2_Silent_p.P4P|CDK10_uc010cip.2_5'UTR|CDK10_uc010vpl.1_Silent_p.P4P|CDK10_uc002fob.2_5'UTR|CDK10_uc002fod.2_5'UTR|CDK10_uc002foe.2_5'UTR|CDK10_uc002fof.2_5'UTR|CDK10_uc002fog.3_5'UTR|CDK10_uc002foh.3_5'UTR	NM_052988	NP_443714	Q15131	CDK10_HUMAN	cyclin-dependent kinase 10 isoform a	4					negative regulation of cell proliferation|traversing start control point of mitotic cell cycle		ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(1)	1		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0276)		TGGCGGAGCCAGATCTGGAGT	0.697000													3	6					0	0	0.115264	0	0
TP53	7157	broad.mit.edu	37	17	7578458	7578458	+	Missense_Mutation	SNP	G	C	C			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr17:7578458G>C	uc002gim.2	-	5	666	c.472C>G	c.(472-474)CGC>GGC	p.R158G	TP53_uc002gig.1_Missense_Mutation_p.R158G|TP53_uc002gih.2_Missense_Mutation_p.R158G|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R26G|TP53_uc010cng.1_Missense_Mutation_p.R26G|TP53_uc002gii.1_Missense_Mutation_p.R26G|TP53_uc010cnh.1_Missense_Mutation_p.R158G|TP53_uc010cni.1_Missense_Mutation_p.R158G|TP53_uc002gij.2_Missense_Mutation_p.R158G|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R65G|TP53_uc002gio.2_Missense_Mutation_p.R26G|TP53_uc010vug.1_Missense_Mutation_p.R119G	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	158	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R158H(58)|p.R158L(53)|p.R158C(17)|p.R158G(10)|p.R158P(9)|p.0?(7)|p.R158R(6)|p.R158fs*12(5)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.R158fs*11(2)|p.V157fs*22(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.V157_R158delVR(1)|p.P151_V173del23(1)|p.R158fs*24(1)|p.R156_R158delRVR(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.R156fs*12(1)|p.R158F(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCATGGCGCGGACGCGGGTG	0.622000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			19	33					0	0	0.575678	0	0
MYH2	4620	broad.mit.edu	37	17	10442867	10442867	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr17:10442867G>A	uc010coi.2	-	13	1288	c.1160C>T	c.(1159-1161)GCG>GTG	p.A387V	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.A387V|MYH2_uc010coj.2_Missense_Mutation_p.A387V	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	387	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						GAGGTAGGCCGCCTTGTCAGC	0.428000													39	53					0	0	0.796494	0	0
FAM83G	644815	broad.mit.edu	37	17	18874945	18874945	+	Silent	SNP	G	A	A			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr17:18874945G>A	uc002guw.2	-	6	2366	c.2199C>T	c.(2197-2199)AAC>AAT	p.N733N	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	733										ovary(1)|central_nervous_system(1)	2						CTGGGCCAGCGTTTCTGGTAG	0.642000													10	38					0	0	0.387290	0	0
NF1	4763	broad.mit.edu	37	17	29677227	29677227	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr17:29677227C>T	uc002hgg.2	+	50	7681	c.7348C>T	c.(7348-7350)CGA>TGA	p.R2450*	NF1_uc002hgh.2_Nonsense_Mutation_p.R2429*|NF1_uc010cso.2_Nonsense_Mutation_p.R638*|NF1_uc010wbt.1_5'UTR|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2450					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.R2450*(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TGAAGAAGTTCGAAGTCGCTG	0.363000			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			24	94					0	0	0.681144	0	0
ACACA	31	broad.mit.edu	37	17	35580444	35580444	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr17:35580444C>T	uc002hnm.2	-	28	3633	c.3442G>A	c.(3442-3444)GCA>ACA	p.A1148T	ACACA_uc002hnk.2_Missense_Mutation_p.A1070T|ACACA_uc002hnl.2_Missense_Mutation_p.A1090T|ACACA_uc002hnn.2_Missense_Mutation_p.A1148T|ACACA_uc002hno.2_Missense_Mutation_p.A1185T|ACACA_uc010cuz.2_Missense_Mutation_p.A1148T	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1148					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TCCAGAGCTGCCATCCTCACT	0.403000													20	118					0	0	0.575678	0	0
ITGA2B	3674	broad.mit.edu	37	17	42455842	42455842	+	Missense_Mutation	SNP	A	C	C			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr17:42455842A>C	uc002igt.1	-	20	2014	c.1982T>G	c.(1981-1983)GTC>GGC	p.V661G	ITGA2B_uc002igu.1_Missense_Mutation_p.V142G	NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	661	Extracellular (Potential).				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	CAGCTCCAGGACATTATCTGC	0.657000													4	17					0	0	0.184627	0	0
MAPRE2	10982	broad.mit.edu	37	18	32677539	32677539	+	Missense_Mutation	SNP	G	T	T			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr18:32677539G>T	uc002kyg.2	+	3	560	c.380G>T	c.(379-381)CGA>CTA	p.R127L	MAPRE2_uc010xcb.1_Missense_Mutation_p.R84L|MAPRE2_uc010xcc.1_Missense_Mutation_p.R115L|MAPRE2_uc002kyf.2_Missense_Mutation_p.R127L|MAPRE2_uc002kyh.2_Missense_Mutation_p.R74L|MAPRE2_uc010xcd.1_Missense_Mutation_p.R84L	NM_014268	NP_055083	Q15555	MARE2_HUMAN	microtubule-associated protein, RP/EB family,	127	CH.				cell division|cell proliferation|mitosis|signal transduction	cytoplasm|microtubule	microtubule binding			ovary(1)	1						TCATTTAAGCGAATGAACGTT	0.343000													7	33					6.5536e-12	7.67707e-12	0.278610	1	0
DYM	54808	broad.mit.edu	37	18	46812851	46812851	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr18:46812851G>A	uc002ldi.1	-	9	1264	c.899C>T	c.(898-900)GCG>GTG	p.A300V	DYM_uc010xdf.1_Missense_Mutation_p.A110V|DYM_uc002ldj.3_Missense_Mutation_p.A122V	NM_017653	NP_060123	Q7RTS9	DYM_HUMAN	dymeclin	300						Golgi apparatus					0						GGGGTTTGGCGCATCTGAGGC	0.488000													17	107					0	0	0.520397	0	0
LILRA1	11024	broad.mit.edu	37	19	55107882	55107882	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr19:55107882G>A	uc002qgh.1	+	7	1369	c.1187G>A	c.(1186-1188)AGG>AAG	p.R396K	LILRA2_uc010yfg.1_Missense_Mutation_p.R394K|LILRA1_uc010yfh.1_Missense_Mutation_p.R396K	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	396	Ig-like C2-type 4.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		GGGACCTACAGGTGCTACGGC	0.587000													22	88					0	0	0.608945	0	0
ZNF17	7565	broad.mit.edu	37	19	57932287	57932287	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr19:57932287G>A	uc002qoo.1	+	3	1658	c.1427G>A	c.(1426-1428)GGC>GAC	p.G476D	ZNF547_uc002qpm.3_Intron|ZNF17_uc002qop.1_Missense_Mutation_p.G478D	NM_006959	NP_008890	P17021	ZNF17_HUMAN	zinc finger protein 17	476	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0234)|GBM - Glioblastoma multiforme(193;0.000426)|Lung(386;0.176)		AGTGAATGTGGCAAATTCTTT	0.413000													5	138					0	0	0.184627	0	0
KIDINS220	57498	broad.mit.edu	37	2	8958894	8958894	+	Silent	SNP	G	A	A			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr2:8958894G>A	uc002qzc.2	-	3	320	c.138C>T	c.(136-138)GCC>GCT	p.A46A	KIDINS220_uc010yiv.1_Intron|KIDINS220_uc002qzd.2_Silent_p.A4A|KIDINS220_uc010yiw.1_Silent_p.A46A	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	46	Cytoplasmic (Potential).|ANK 2.				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TGCCTTGTTCGGCAGCTATCA	0.328000													18	67					0	0	0.608945	0	0
MAP4K4	9448	broad.mit.edu	37	2	102503626	102503626	+	Missense_Mutation	SNP	A	G	G			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr2:102503626A>G	uc002tbg.2	+	27	3318	c.3263A>G	c.(3262-3264)TAT>TGT	p.Y1088C	MAP4K4_uc002tbc.2_Missense_Mutation_p.Y1169C|MAP4K4_uc002tbd.2_Missense_Mutation_p.Y1061C|MAP4K4_uc002tbe.2_Missense_Mutation_p.Y1007C|MAP4K4_uc002tbf.2_Missense_Mutation_p.Y1122C|MAP4K4_uc010yvy.1_Missense_Mutation_p.Y1084C|MAP4K4_uc002tbh.2_Missense_Mutation_p.Y1006C|MAP4K4_uc002tbi.2_Missense_Mutation_p.Y891C|MAP4K4_uc010yvz.1_Missense_Mutation_p.Y1128C|MAP4K4_uc002tbk.2_Missense_Mutation_p.Y543C|MAP4K4_uc002tbl.2_Missense_Mutation_p.Y274C	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	1088	CNH.|Mediates interaction with RAP2A.				intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4						AAAGTGATCTATGGATCCTGT	0.423000													3	17					0	0	0.115264	0	0
USP37	57695	broad.mit.edu	37	2	219418446	219418446	+	Missense_Mutation	SNP	A	G	G			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr2:219418446A>G	uc002vie.2	-	5	611	c.158T>C	c.(157-159)CTA>CCA	p.L53P	USP37_uc010fvs.1_Missense_Mutation_p.L53P|USP37_uc010zkf.1_Missense_Mutation_p.L53P|USP37_uc002vif.2_Missense_Mutation_p.L53P|USP37_uc002vig.2_5'UTR|USP37_uc010zkg.1_Missense_Mutation_p.L53P	NM_020935	NP_065986	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	53					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(3)|ovary(1)|prostate(1)	5		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		GTTATGACTTAGCTAATCAAG	0.318000													3	43					0	0	0.150653	0	0
RTEL1	51750	broad.mit.edu	37	20	62321451	62321451	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr20:62321451C>T	uc002yfu.1	+	25	2496	c.2153C>T	c.(2152-2154)GCC>GTC	p.A718V	RTEL1_uc011abc.1_RNA|RTEL1_uc002yft.1_Missense_Mutation_p.A718V|RTEL1_uc011abd.1_Missense_Mutation_p.A742V|RTEL1_uc011abe.1_Missense_Mutation_p.A495V|RTEL1_uc002yfw.2_RNA|RTEL1_uc002yfx.1_5'UTR	NM_016434	NP_057518	Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	718					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding				0	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			TTCGCCTTTGCCGACGCAAGA	0.617000													3	82					0	0	0.150653	0	0
LMF2	91289	broad.mit.edu	37	22	50943889	50943889	+	Missense_Mutation	SNP	C	A	A			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr22:50943889C>A	uc003blp.2	-	7	1025	c.994G>T	c.(994-996)GTG>TTG	p.V332L	LMF2_uc010hba.2_Missense_Mutation_p.V154L|LMF2_uc003blo.2_Missense_Mutation_p.V307L|NCAPH2_uc003blq.3_5'Flank|NCAPH2_uc003blv.2_5'Flank|NCAPH2_uc003blr.3_5'Flank|NCAPH2_uc010hbb.2_5'Flank|NCAPH2_uc003blu.3_5'Flank|NCAPH2_uc003bls.3_5'Flank|NCAPH2_uc003blt.3_5'Flank|NCAPH2_uc003blw.3_5'Flank|NCAPH2_uc003blx.3_5'Flank|NCAPH2_uc003bly.3_5'Flank	NM_033200	NP_149977	Q9BU23	LMF2_HUMAN	lipase maturation factor 2	332						endoplasmic reticulum membrane|integral to membrane				breast(1)	1		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		AAGTAGTGCACAGTGCCATAG	0.662000													20	85					7.45023e-12	8.48498e-12	0.592651	1	0
CCDC66	285331	broad.mit.edu	37	3	56627603	56627603	+	Missense_Mutation	SNP	A	G	G			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr3:56627603A>G	uc003dhz.2	+	9	1240	c.1153A>G	c.(1153-1155)ACA>GCA	p.T385A	CCDC66_uc003dhy.2_Missense_Mutation_p.T21A|CCDC66_uc003dhu.2_Missense_Mutation_p.T351A|CCDC66_uc003dhx.2_RNA	NM_001141947	NP_001135419	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66 isoform 1	385										breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		CTCTCAGTCAACACACAAACA	0.453000													10	53					0	0	0.361761	0	0
MYLK	4638	broad.mit.edu	37	3	123444812	123444812	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr3:123444812G>A	uc003ego.2	-	12	1912	c.1630C>T	c.(1630-1632)CGG>TGG	p.R544W	MYLK_uc011bjw.1_Missense_Mutation_p.R544W|MYLK_uc003egp.2_Missense_Mutation_p.R475W|MYLK_uc003egq.2_Missense_Mutation_p.R544W|MYLK_uc003egr.2_Missense_Mutation_p.R475W|MYLK_uc003egs.2_Missense_Mutation_p.R368W	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	544	Ig-like C2-type 4.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CAAGTGATCCGGGGCACTGGG	0.617000													12	19					0	0	0.411799	0	0
UMPS	7372	broad.mit.edu	37	3	124449455	124449455	+	Missense_Mutation	SNP	G	T	T			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr3:124449455G>T	uc003ehl.3	+	1	243	c.137G>T	c.(136-138)CGA>CTA	p.R46L	UMPS_uc003ehm.3_RNA|UMPS_uc011bka.1_5'UTR|UMPS_uc011bkb.1_5'UTR|UMPS_uc011bkc.1_5'UTR|UMPS_uc003ehn.3_5'UTR|UMPS_uc011bkd.1_5'UTR|hsa-mir-544b|MI0014159_5'Flank	NM_000373	NP_000364	P11172	UMPS_HUMAN	uridine monophosphate synthase	46	OPRTase.				'de novo' pyrimidine base biosynthetic process|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process	cytosol|nucleus	orotate phosphoribosyltransferase activity|orotidine-5'-phosphate decarboxylase activity			kidney(1)	1				GBM - Glioblastoma multiforme(114;0.146)		ATCGTGTCTCGACCGCGTCTT	0.587000													11	31					2.80697e-09	3.11043e-09	0.387290	1	0
RAI14	26064	broad.mit.edu	37	5	34811934	34811934	+	Missense_Mutation	SNP	A	G	G			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr5:34811934A>G	uc003jir.2	+	9	816	c.620A>G	c.(619-621)AAG>AGG	p.K207R	RAI14_uc010iur.2_Missense_Mutation_p.K207R|RAI14_uc011coj.1_Missense_Mutation_p.K207R|RAI14_uc010ius.1_Missense_Mutation_p.K136R|RAI14_uc003jis.2_Missense_Mutation_p.K210R|RAI14_uc003jit.2_Missense_Mutation_p.K207R|RAI14_uc011cok.1_Missense_Mutation_p.K199R	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	207	ANK 6.					cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					TTAATTAAAAAGGGTGCAGAC	0.383000													3	78					0	0	0.115264	0	0
RELN	5649	broad.mit.edu	37	7	103290796	103290796	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr7:103290796C>T	uc003vca.2	-	16	2087	c.1927G>A	c.(1927-1929)GCA>ACA	p.A643T	RELN_uc010liz.2_Missense_Mutation_p.A643T	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	643					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CGGGTTAGTGCTGCGTTAGGA	0.403000													3	77					0	0	0.115264	0	0
COL22A1	169044	broad.mit.edu	37	8	139636001	139636001	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr8:139636001C>T	uc003yvd.2	-	52	4192	c.3745G>A	c.(3745-3747)GGA>AGA	p.G1249R	COL22A1_uc011ljo.1_Missense_Mutation_p.G529R	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1249	Pro-rich.|Gly-rich.|Collagen-like 12.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CCCGGCTTTCCATCTCTGCCC	0.418000										HNSCC(7;0.00092)			48	248					0	0	0.870114	0	0
FAM75C1	441452	broad.mit.edu	37	9	90537434	90537434	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr9:90537434C>T	uc010mqi.2	+	4	2641	c.2612C>T	c.(2611-2613)ACG>ATG	p.T871M	FAM75C1_uc004apq.3_Missense_Mutation_p.T854M	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						GGAATGGCCACGAAGTCAGAG	0.507000													22	97					0	0	0.667858	0	0
ZNF630	57232	broad.mit.edu	37	X	47920207	47920207	+	Missense_Mutation	SNP	C	A	A			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chrX:47920207C>A	uc004div.3	-	3	385	c.133G>T	c.(133-135)GTC>TTC	p.V45F	ZNF630_uc010nhz.1_RNA|ZNF630_uc004diw.2_5'UTR	NM_001037735	NP_001032824	Q2M218	ZN630_HUMAN	zinc finger protein 630	45	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|lung(1)	2						CCCACGGAGACCAGGTGATTA	0.483000													7	4					0.00198382	0.00208555	0.248553	1	0
GSPT2	23708	broad.mit.edu	37	X	51488255	51488255	+	Missense_Mutation	SNP	T	A	A			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chrX:51488255T>A	uc004dpl.2	+	1	1759	c.1533T>A	c.(1531-1533)GAT>GAA	p.D511E		NM_018094	NP_060564	Q8IYD1	ERF3B_HUMAN	peptide chain release factor 3	511					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1	Ovarian(276;0.236)					TACTTTGTGATCCTAGTAACC	0.418000													23	25					0	0	0.624587	0	0
SSX8	280659	broad.mit.edu	37	X	52655349	52655349	+	RNA	SNP	T	A	A	rs34990448	by1000genomes	TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chrX:52655349T>A	uc011moa.1	+	4		c.476T>A			SSX8_uc011mob.1_RNA					Homo sapiens cDNA FLJ56587 complete cds, highly similar to Protein SSX8.												0						TAGGTTTCAATGTCACCCTCC	0.308000													3	58					0	0	0.115264	0	0
ATRX	546	broad.mit.edu	37	X	76813115	76813115	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chrX:76813115C>T	uc004ecp.3	-	30	6738	c.6506G>A	c.(6505-6507)GGA>GAA	p.G2169E	ATRX_uc004ecq.3_Missense_Mutation_p.G2131E|ATRX_uc004eco.3_Missense_Mutation_p.G1954E	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	2169	Helicase C-terminal.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTCCATGGTTCCCTTTGTAAA	0.328000			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						19	26					0	0	0.575678	0	0
NF1	4763	broad.mit.edu	37	17	29683983	29683984	+	Frame_Shift_Ins	INS	-	A	A			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr17:29683983_29683984insA	uc002hgg.2	+	53	8077_8078	c.7744_7745insA	c.(7744-7746)CAGfs	p.Q2582fs	NF1_uc002hgh.2_Frame_Shift_Ins_p.Q2561fs|NF1_uc010cso.2_Frame_Shift_Ins_p.Q770fs|NF1_uc010wbt.1_Frame_Shift_Ins_p.Q60fs|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2582					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TGCAGAAACTCAGAGGATTTCC	0.371			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			37	194	---	---	---	---					
C20orf135	140701	broad.mit.edu	37	20	62494293	62494293	+	Frame_Shift_Del	DEL	G	-	-			TCGA-FG-5963-01A-11D-1705-08	TCGA-FG-5963-11A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	22326318-2d69-4163-96f3-2729ac0ed905	8db33879-438e-4e72-a0f5-46f899011432	g.chr20:62494293delG	uc002ygx.1	+	1	1728	c.1400delG	c.(1399-1401)TGGfs	p.W467fs	TPD52L2_uc002ygy.2_5'Flank|TPD52L2_uc002ygz.2_5'Flank|TPD52L2_uc002yha.2_5'Flank|TPD52L2_uc002yhb.2_5'Flank|TPD52L2_uc002yhc.2_5'Flank|TPD52L2_uc002yhd.2_5'Flank|TPD52L2_uc011abk.1_5'Flank|TPD52L2_uc011abl.1_5'Flank	NM_080622	NP_542189	Q9H3Z7	ABHGB_HUMAN	hypothetical protein LOC140701	467							hydrolase activity				0	all_cancers(38;1.77e-12)|all_epithelial(29;3.12e-14)|Lung NSC(23;5.92e-10)|all_lung(23;2.08e-09)					CAGTTGCCCTGGCGGCTGTAA	0.577													2	4	---	---	---	---					
