Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HIVEP3	59269	broad.mit.edu	37	1	42049093	42049093	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-6691-01A-11D-1893-08	TCGA-FG-6691-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d309c4d-9bb3-48ee-a662-c9aec672fcbd	4587f277-e82b-4c27-94ad-ae5de4bc706f	g.chr1:42049093G>A	uc001cgz.3	-	4	2589	c.1376C>T	c.(1375-1377)ACG>ATG	p.T459M	HIVEP3_uc001cha.3_Missense_Mutation_p.T459M|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	459	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GATCACCTGCGTCCGGGGTAC	0.637000													12	48					0	0	0.000978159	0	0
LOC642846	642846	broad.mit.edu	37	12	9453702	9453702	+	RNA	SNP	C	T	T			TCGA-FG-6691-01A-11D-1893-08	TCGA-FG-6691-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d309c4d-9bb3-48ee-a662-c9aec672fcbd	4587f277-e82b-4c27-94ad-ae5de4bc706f	g.chr12:9453702C>T	uc010sgp.1	+	10		c.1341C>T			LOC642846_uc001qvp.2_RNA	NR_024374				Homo sapiens cDNA FLJ60280 complete cds, highly similar to Probable ATP-dependent RNA helicase DDX11 (EC 3.6.1.-).												0						GGTGGTGCTGCCCTATCAGAT	0.662000													4	11					0	0	0.000602214	0	0
ADAM6	8755	broad.mit.edu	37	14	106757779	106757779	+	RNA	SNP	G	A	A			TCGA-FG-6691-01A-11D-1893-08	TCGA-FG-6691-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d309c4d-9bb3-48ee-a662-c9aec672fcbd	4587f277-e82b-4c27-94ad-ae5de4bc706f	g.chr14:106757779G>A	uc010tyt.1	-	472		c.16286C>T								Parts of antibodies, mostly variable regions.												0						AGGATTTTTCGTCATTCGAAA	0.532000													27	58					0	0	0.00395357	0	0
SEMA7A	8482	broad.mit.edu	37	15	74709961	74709961	+	Missense_Mutation	SNP	G	A	A	rs140327601		TCGA-FG-6691-01A-11D-1893-08	TCGA-FG-6691-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d309c4d-9bb3-48ee-a662-c9aec672fcbd	4587f277-e82b-4c27-94ad-ae5de4bc706f	g.chr15:74709961G>A	uc002axv.2	-	5	561	c.521C>T	c.(520-522)CCG>CTG	p.P174L	SEMA7A_uc010ulk.1_Missense_Mutation_p.P9L|SEMA7A_uc010ull.1_Missense_Mutation_p.P160L	NM_003612	NP_003603	O75326	SEM7A_HUMAN	semaphorin 7A isoform 1 preproprotein	174	Sema.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(1)|central_nervous_system(1)	2						GTTCTCGTCCGGGCTGAAGGG	0.612000													15	33					0	0	0.00074312	0	0
TSPAN16	26526	broad.mit.edu	37	19	11417342	11417342	+	Silent	SNP	G	A	A			TCGA-FG-6691-01A-11D-1893-08	TCGA-FG-6691-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d309c4d-9bb3-48ee-a662-c9aec672fcbd	4587f277-e82b-4c27-94ad-ae5de4bc706f	g.chr19:11417342G>A	uc002mqv.1	+	5	663	c.513G>A	c.(511-513)ACG>ACA	p.T171T	TSPAN16_uc002mqu.1_RNA|uc002mqw.1_Intron	NM_012466	NP_036598	Q9UKR8	TSN16_HUMAN	transmembrane 4 superfamily member 16	171	Cytoplasmic (Potential).					integral to membrane				skin(1)	1						AAATGACAACGGGCCACACCT	0.488000													5	65					0	0	0.00198382	0	0
OR10H3	26532	broad.mit.edu	37	19	15852474	15852474	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-6691-01A-11D-1893-08	TCGA-FG-6691-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d309c4d-9bb3-48ee-a662-c9aec672fcbd	4587f277-e82b-4c27-94ad-ae5de4bc706f	g.chr19:15852474G>A	uc010xoq.1	+	1	272	c.272G>A	c.(271-273)CGT>CAT	p.R91H		NM_013938	NP_039226	O60404	O10H3_HUMAN	olfactory receptor, family 10, subfamily H,	91	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTCACCCATCGTTCCATCACC	0.498000													10	381					0	0	0.00185496	0	0
RPSAP58	388524	broad.mit.edu	37	19	24010294	24010294	+	Missense_Mutation	SNP	C	G	G			TCGA-FG-6691-01A-11D-1893-08	TCGA-FG-6691-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d309c4d-9bb3-48ee-a662-c9aec672fcbd	4587f277-e82b-4c27-94ad-ae5de4bc706f	g.chr19:24010294C>G	uc002nrn.2	+	4	754	c.331C>G	c.(331-333)CAG>GAG	p.Q111E		NM_002295	NP_002286			ribosomal protein SA												0						CTTCACTAACCAGATCCAGGC	0.567000													4	52					0	0	0.00024832	0	0
VIT	5212	broad.mit.edu	37	2	37032683	37032683	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-6691-01A-11D-1893-08	TCGA-FG-6691-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d309c4d-9bb3-48ee-a662-c9aec672fcbd	4587f277-e82b-4c27-94ad-ae5de4bc706f	g.chr2:37032683C>T	uc002rpl.2	+	14	1486	c.1265C>T	c.(1264-1266)ACG>ATG	p.T422M	VIT_uc002rpm.2_Missense_Mutation_p.T400M|VIT_uc010ezv.2_Missense_Mutation_p.T378M|VIT_uc010ezw.2_Missense_Mutation_p.T379M	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	407	VWFA 1.					proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				GGCTGGCCCACGGACAAAGTG	0.502000													16	85					0	0	0.00400662	0	0
DYNC2LI1	51626	broad.mit.edu	37	2	44021694	44021694	+	Missense_Mutation	SNP	A	G	G			TCGA-FG-6691-01A-11D-1893-08	TCGA-FG-6691-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d309c4d-9bb3-48ee-a662-c9aec672fcbd	4587f277-e82b-4c27-94ad-ae5de4bc706f	g.chr2:44021694A>G	uc002rtk.2	+	6	515	c.419A>G	c.(418-420)AAA>AGA	p.K140R	DYNC2LI1_uc002rth.2_Missense_Mutation_p.K140R|DYNC2LI1_uc002rti.2_3'UTR|DYNC2LI1_uc002rtj.2_Missense_Mutation_p.K140R|DYNC2LI1_uc002rtl.2_Missense_Mutation_p.K140R|DYNC2LI1_uc010ynz.1_Missense_Mutation_p.K14R	NM_016008	NP_057092	Q8TCX1	DC2L1_HUMAN	dynein 2 light intermediate chain isoform 1	140						apical part of cell|axonemal dynein complex|cilium axoneme|cytoplasm|microtubule|motile primary cilium	motor activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CATGTAGACAAAGTGATAATG	0.408000													4	65					0	0	0.000602214	0	0
IDH1	3417	broad.mit.edu	37	2	209113113	209113113	+	Missense_Mutation	SNP	G	T	T	rs121913499		TCGA-FG-6691-01A-11D-1893-08	TCGA-FG-6691-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d309c4d-9bb3-48ee-a662-c9aec672fcbd	4587f277-e82b-4c27-94ad-ae5de4bc706f	g.chr2:209113113G>T	uc002vcs.2	-	4	640	c.394C>A	c.(394-396)CGT>AGT	p.R132S	IDH1_uc002vct.2_Missense_Mutation_p.R132S|IDH1_uc002vcu.2_Missense_Mutation_p.R132S	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		TAAGCATGACGACCTATGATG	0.398000			Mis		gliobastoma 								20	39					1.10923e-09	5.35325e-09	0.00278032	1	0
MAP3K13	9175	broad.mit.edu	37	3	185161243	185161243	+	Missense_Mutation	SNP	A	G	G			TCGA-FG-6691-01A-11D-1893-08	TCGA-FG-6691-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d309c4d-9bb3-48ee-a662-c9aec672fcbd	4587f277-e82b-4c27-94ad-ae5de4bc706f	g.chr3:185161243A>G	uc010hyf.2	+	5	936	c.670A>G	c.(670-672)ACT>GCT	p.T224A	MAP3K13_uc011brt.1_Missense_Mutation_p.T17A|MAP3K13_uc003fph.3_5'UTR|MAP3K13_uc011bru.1_Missense_Mutation_p.T80A|MAP3K13_uc003fpi.2_Missense_Mutation_p.T224A|MAP3K13_uc010hyg.2_Intron	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	224	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			GGGTGTTTGTACTCAGGCCCC	0.303000													3	59					0	0	6.4e-05	0	0
MUC7	4589	broad.mit.edu	37	4	71347534	71347534	+	Missense_Mutation	SNP	G	A	A	rs145866670		TCGA-FG-6691-01A-11D-1893-08	TCGA-FG-6691-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d309c4d-9bb3-48ee-a662-c9aec672fcbd	4587f277-e82b-4c27-94ad-ae5de4bc706f	g.chr4:71347534G>A	uc011cat.1	+	4	1361	c.1073G>A	c.(1072-1074)CGA>CAA	p.R358Q	MUC7_uc011cau.1_Missense_Mutation_p.R358Q|MUC7_uc003hfj.2_Missense_Mutation_p.R358Q|uc011cav.1_RNA	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	358						extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			AAAATTTCTCGATTTCTTTTA	0.358000													5	69					0	0	0.000602214	0	0
WBSCR17	64409	broad.mit.edu	37	7	70853295	70853295	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-6691-01A-11D-1893-08	TCGA-FG-6691-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d309c4d-9bb3-48ee-a662-c9aec672fcbd	4587f277-e82b-4c27-94ad-ae5de4bc706f	g.chr7:70853295C>T	uc003tvy.2	+	3	497	c.497C>T	c.(496-498)TCG>TTG	p.S166L	WBSCR17_uc003tvz.2_5'UTR	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	166	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GAGGCCCTGTCGGTGATCCTG	0.542000													7	68					0	0	0.00198382	0	0
LONRF1	91694	broad.mit.edu	37	8	12595574	12595574	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-6691-01A-11D-1893-08	TCGA-FG-6691-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d309c4d-9bb3-48ee-a662-c9aec672fcbd	4587f277-e82b-4c27-94ad-ae5de4bc706f	g.chr8:12595574T>C	uc003wwd.1	-	4	1106	c.1043A>G	c.(1042-1044)AAA>AGA	p.K348R	LONRF1_uc011kxv.1_5'Flank|LONRF1_uc010lsp.1_5'UTR	NM_152271	NP_689484	Q17RB8	LONF1_HUMAN	LON peptidase N-terminal domain and ring finger	348					proteolysis		ATP-dependent peptidase activity|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(644;0.236)		AGGTCTGTTTTTAGTACATGG	0.363000													16	41					0	0	0.00400662	0	0
MMP16	4325	broad.mit.edu	37	8	89339322	89339322	+	Missense_Mutation	SNP	C	G	G			TCGA-FG-6691-01A-11D-1893-08	TCGA-FG-6691-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d309c4d-9bb3-48ee-a662-c9aec672fcbd	4587f277-e82b-4c27-94ad-ae5de4bc706f	g.chr8:89339322C>G	uc003yeb.3	-	1	396	c.114G>C	c.(112-114)GAG>GAC	p.E38D	MMP16_uc003yec.2_Missense_Mutation_p.E38D	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	38					collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						TGAAATACTGCTCCGTTCCGC	0.507000													3	104					0	0	0.00024832	0	0
GPRASP1	9737	broad.mit.edu	37	X	101909851	101909851	+	Missense_Mutation	SNP	G	C	C			TCGA-FG-6691-01A-11D-1893-08	TCGA-FG-6691-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d309c4d-9bb3-48ee-a662-c9aec672fcbd	4587f277-e82b-4c27-94ad-ae5de4bc706f	g.chrX:101909851G>C	uc004ejj.3	+	5	1811	c.1010G>C	c.(1009-1011)CGA>CCA	p.R337P	GPRASP1_uc004eji.3_Missense_Mutation_p.R337P|GPRASP1_uc010nod.2_Missense_Mutation_p.R337P	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	337						cytoplasm	protein binding			ovary(1)|lung(1)	2						AGGGCCAAGCGAGAAGCTTGC	0.478000													5	107					0	0	0.00116845	0	0
GPRASP1	9737	broad.mit.edu	37	X	101910618	101910618	+	Missense_Mutation	SNP	G	C	C			TCGA-FG-6691-01A-11D-1893-08	TCGA-FG-6691-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d309c4d-9bb3-48ee-a662-c9aec672fcbd	4587f277-e82b-4c27-94ad-ae5de4bc706f	g.chrX:101910618G>C	uc004ejj.3	+	5	2578	c.1777G>C	c.(1777-1779)GAT>CAT	p.D593H	GPRASP1_uc004eji.3_Missense_Mutation_p.D593H|GPRASP1_uc010nod.2_Missense_Mutation_p.D593H	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	593	Glu-rich.					cytoplasm	protein binding			ovary(1)|lung(1)	2						GACCTATATGGATTGTAGGGC	0.507000													3	134					0	0	6.4e-05	0	0
TP53	7157	broad.mit.edu	37	17	7578444	7578449	+	In_Frame_Del	DEL	GATGGC	-	-			TCGA-FG-6691-01A-11D-1893-08	TCGA-FG-6691-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d309c4d-9bb3-48ee-a662-c9aec672fcbd	4587f277-e82b-4c27-94ad-ae5de4bc706f	g.chr17:7578444_7578449delGATGGC	uc002gim.2	-	5	675_680	c.481_486delGCCATC	c.(481-486)GCCATCdel	p.AI161del	TP53_uc002gig.1_In_Frame_Del_p.AI161del|TP53_uc002gih.2_In_Frame_Del_p.AI161del|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_In_Frame_Del_p.AI29del|TP53_uc010cng.1_In_Frame_Del_p.AI29del|TP53_uc002gii.1_In_Frame_Del_p.AI29del|TP53_uc010cnh.1_In_Frame_Del_p.AI161del|TP53_uc010cni.1_In_Frame_Del_p.AI161del|TP53_uc002gij.2_In_Frame_Del_p.AI161del|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_In_Frame_Del_p.AI68del|TP53_uc002gio.2_In_Frame_Del_p.AI29del|TP53_uc010vug.1_In_Frame_Del_p.AI122del	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	161_162	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		I -> S (in sporadic cancers; somatic mutation).|I -> N (in a breast cancer with no family history; germline mutation and in sporadic cancers; somatic mutation).|I -> V (in sporadic cancers; somatic mutation).|I -> T (in sporadic cancers; somatic mutation).|I -> M (in sporadic cancers; somatic mutation).|I -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A161T(44)|p.I162F(8)|p.A161D(8)|p.0?(7)|p.A161V(7)|p.I162V(5)|p.A161A(5)|p.I162I(4)|p.I162S(4)|p.I162N(3)|p.I162M(3)|p.A161fs*9(3)|p.R156_I162delRVRAMAI(2)|p.M160fs*10(2)|p.I162fs*19(2)|p.V157_C176del20(1)|p.A161fs*19(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156fs*18(1)|p.A161fs*10(1)|p.R156_A161del(1)|p.V157fs*9(1)|p.I162_Y163delIY(1)|p.A161fs*20(1)|p.M160_A161>IS(1)|p.A161fs*8(1)|p.A161G(1)|p.S149fs*72(1)|p.I162fs*8(1)|p.A161fs*7(1)|p.T155_A161delTRVRAMA(1)|p.R156fs*20(1)|p.A161S(1)|p.A161P(1)|p.V157_I162delVRAMAI(1)|p.A161F(1)|p.A159_Q167delAMAIYKQSQ(1)|p.Y163fs*18(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACTGCTTGTAGATGGCCATGGCGCGG	0.631		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			38	25	---	---	---	---					
KIAA1009	22832	broad.mit.edu	37	6	84896233	84896233	+	Frame_Shift_Del	DEL	A	-	-			TCGA-FG-6691-01A-11D-1893-08	TCGA-FG-6691-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d309c4d-9bb3-48ee-a662-c9aec672fcbd	4587f277-e82b-4c27-94ad-ae5de4bc706f	g.chr6:84896233delA	uc010kbp.2	-	12	1315	c.1218delT	c.(1216-1218)TTTfs	p.F406fs	KIAA1009_uc003pkj.3_Frame_Shift_Del_p.F330fs|KIAA1009_uc003pkk.2_Frame_Shift_Del_p.F406fs|KIAA1009_uc003pki.3_5'UTR	NM_014895	NP_055710	Q5TB80	QN1_HUMAN	KIAA1009 protein	406					cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			ovary(1)	1		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		CATTTTTGTCAAAAAAAAGGT	0.358													7	191	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76939673	76939674	+	Frame_Shift_Ins	INS	-	T	T			TCGA-FG-6691-01A-11D-1893-08	TCGA-FG-6691-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d309c4d-9bb3-48ee-a662-c9aec672fcbd	4587f277-e82b-4c27-94ad-ae5de4bc706f	g.chrX:76939673_76939674insT	uc004ecp.3	-	9	1306_1307	c.1074_1075insA	c.(1072-1077)AAACTGfs	p.K358fs	ATRX_uc004ecq.3_Frame_Shift_Ins_p.K320fs|ATRX_uc004eco.3_Frame_Shift_Ins_p.K143fs|ATRX_uc004ecr.2_Frame_Shift_Ins_p.K319fs|ATRX_uc010nlx.1_Frame_Shift_Ins_p.K358fs|ATRX_uc010nly.1_Frame_Shift_Ins_p.K303fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	358_359					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	GTCTCAATCAGTTTTTTTGCCT	0.366			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						53	96	---	---	---	---					
