Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OR10J5	127385	broad.mit.edu	37	1	159505463	159505463	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr1:159505463C>T	uc010piw.1	-	1	335	c.335G>A	c.(334-336)TGC>TAC	p.C112Y		NM_001004469	NP_001004469	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_hematologic(112;0.0429)					AAGCAGGAAGCAATTATTAGT	0.468000													39	50					0	0	0.042209	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37430773	37430773	+	Silent	SNP	G	A	A			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr10:37430773G>A	uc001iza.1	+	7	879	c.780G>A	c.(778-780)ACG>ACA	p.T260T		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	316						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CACCTGACACGGCTGAAAGCT	0.493000													3	55					0	0	0.004672	0	0
PDE6C	5146	broad.mit.edu	37	10	95381756	95381756	+	Missense_Mutation	SNP	C	T	T	rs143673530	byFrequency	TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr10:95381756C>T	uc001kiu.3	+	4	929	c.791C>T	c.(790-792)GCG>GTG	p.A264V		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	264	GAF 2.				visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				TTTCACAAAGCGCTCTACACG	0.388000													35	57					0	0	0.086207	0	0
F2	2147	broad.mit.edu	37	11	46742097	46742097	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr11:46742097G>A	uc001ndf.3	+	3	308	c.265G>A	c.(265-267)GCT>ACT	p.A89T	F2_uc001ndg.3_RNA	NM_000506	NP_000497	P00734	THRB_HUMAN	coagulation factor II preproprotein	89	Gla.				activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity			ovary(3)	3		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)	CAAGTACACAGGTGAGCACCG	0.532000													4	106					0	0	0.014758	0	0
OR4A5	81318	broad.mit.edu	37	11	51411931	51411931	+	Silent	SNP	C	T	T	rs140587389	byFrequency	TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr11:51411931C>T	uc001nhi.1	-	1	465	c.465G>A	c.(463-465)GCG>GCA	p.A155A		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	155	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				CAATTTGAAACGCAGAATGTA	0.453000													21	32					0	0	0.108266	0	0
RPL13AP20	387841	broad.mit.edu	37	12	13028751	13028751	+	Missense_Mutation	SNP	G	C	C			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr12:13028751G>C	uc010sho.1	+	1	341	c.319G>C	c.(319-321)GGC>CGC	p.G107R		NR_003932				SubName: Full=Ribosomal protein L13a variant; Flags: Fragment;												0						GGTGTTTGACGGCATCCCACC	0.612000													9	26					0	0	0.058154	0	0
OS9	10956	broad.mit.edu	37	12	58110219	58110219	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr12:58110219G>A	uc001spj.2	+	8	976	c.917G>A	c.(916-918)AGT>AAT	p.S306N	OS9_uc010srx.1_Intron|OS9_uc001spk.2_Missense_Mutation_p.S306N|OS9_uc001spl.2_Missense_Mutation_p.S306N|OS9_uc001spm.2_Missense_Mutation_p.S306N|OS9_uc001spn.2_Missense_Mutation_p.S307N|OS9_uc010sry.1_Missense_Mutation_p.S274N|OS9_uc010srz.1_Missense_Mutation_p.S247N	NM_006812	NP_006803	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum	306					ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			ovary(1)	1	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			AAGGATGACAGTAAGGACTCA	0.582000													2	6					0	0	0.004672	0	0
DNAH10	196385	broad.mit.edu	37	12	124358200	124358200	+	Silent	SNP	C	T	T			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr12:124358200C>T	uc001uft.3	+	45	7552	c.7527C>T	c.(7525-7527)TAC>TAT	p.Y2509Y		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2509	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AAGATACTTACGGCCCACCCA	0.473000													6	14					0	0	0.021553	0	0
PCDH9	5101	broad.mit.edu	37	13	67800158	67800158	+	Silent	SNP	T	C	C			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr13:67800158T>C	uc001vik.2	-	2	3107	c.2415A>G	c.(2413-2415)CAA>CAG	p.Q805Q	PCDH9_uc001vil.2_Silent_p.Q805Q|PCDH9_uc010thl.1_Silent_p.Q805Q|PCDH9_uc001vin.3_Silent_p.Q805Q	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	805	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TTTGATAGGGTTGGCTACTAT	0.483000													13	180					0	0	0.033300	0	0
SFTA3	253970	broad.mit.edu	37	14	36946257	36946257	+	Silent	SNP	G	A	A			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr14:36946257G>A	uc001wtr.2	-	3	812	c.180C>T	c.(178-180)TGC>TGT	p.C60C	SFTA3_uc001wtq.2_RNA|SFTA3_uc001wts.2_RNA	NM_001101341	NP_001094811	P0C7M3	SFTA3_HUMAN	surfactant associated 3	60											0						GACTTGGCACGCAAACAGCGA	0.517000													9	142					0	0	0.058154	0	0
NID2	22795	broad.mit.edu	37	14	52509590	52509590	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr14:52509590G>A	uc001wzo.2	-	6	1723	c.1489C>T	c.(1489-1491)CGG>TGG	p.R497W	NID2_uc010tqs.1_Missense_Mutation_p.R497W|NID2_uc010tqt.1_Missense_Mutation_p.R497W|NID2_uc001wzp.2_Missense_Mutation_p.R497W	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	497	EGF-like 1.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					AAGGCATGCCGGGAGCATTGT	0.448000													3	112					0	0	0.004672	0	0
Unknown	0	broad.mit.edu	37	16	15023180	15023180	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr16:15023180C>T	uc010uzk.1	+	6	1025	c.749C>T	c.(748-750)TCG>TTG	p.S250L	NPIP_uc002dcx.3_RNA					SubName: Full=cDNA FLJ57488, highly similar to Polycystin-1;																		GAGTCACCATCGCGGATGGTG	0.667000													3	6					0	0	0.004672	0	0
SLFN11	91607	broad.mit.edu	37	17	33679774	33679774	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr17:33679774C>T	uc010ctp.2	-	7	2749	c.2307G>A	c.(2305-2307)TGG>TGA	p.W769*	SLFN11_uc010ctq.2_Nonsense_Mutation_p.W769*|SLFN11_uc002hjh.3_Nonsense_Mutation_p.W769*|SLFN11_uc002hjg.3_Nonsense_Mutation_p.W769*|SLFN11_uc010ctr.2_Nonsense_Mutation_p.W769*	NM_001104588	NP_001098058	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	769						nucleus	ATP binding			large_intestine(1)|ovary(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CACCCTGGGACCATTCGGCTT	0.443000													19	30					0	0	0.062417	0	0
CDK12	51755	broad.mit.edu	37	17	37676268	37676268	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr17:37676268G>A	uc010cvv.2	+	11	3609	c.3023G>A	c.(3022-3024)CGG>CAG	p.R1008Q	CDK12_uc010wef.1_Missense_Mutation_p.R1007Q|CDK12_uc002hrw.3_Missense_Mutation_p.R1008Q	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	1008	Protein kinase.				mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						CCTAGTAAGCGGTGCACAGCT	0.473000										TCGA Ovarian(9;0.13)			59	160					0	0	0.048971	0	0
Unknown	0	broad.mit.edu	37	17	45127107	45127107	+	Missense_Mutation	SNP	C	G	G	rs147409399	by1000genomes	TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr17:45127107C>G	uc010wkj.1	+	2	659	c.305C>G	c.(304-306)ACC>AGC	p.T102S	uc010wkl.1_RNA					SubName: Full=Putative uncharacterized protein LRRC37A3;																		CCTTCGTTCACCCAAGAGCAT	0.592000													3	80					0	0	0.004672	0	0
C17orf58	284018	broad.mit.edu	37	17	65988073	65988073	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr17:65988073T>C	uc002jgi.3	-	3	565	c.250A>G	c.(250-252)AGG>GGG	p.R84G	C17orf58_uc002jgj.3_3'UTR	NM_181655	NP_858041	Q2M2W7	CQ058_HUMAN	hypothetical protein LOC284018 isoform a	84											0	all_cancers(12;4.57e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)			TGCCCTTCCCTTTTTCGATTA	0.522000													3	144					0	0	0.021553	0	0
SEH1L	81929	broad.mit.edu	37	18	12955479	12955479	+	Silent	SNP	A	G	G	rs140218685	byFrequency	TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr18:12955479A>G	uc002krr.2	+	3	318	c.180A>G	c.(178-180)GTA>GTG	p.V60V	SEH1L_uc002krq.2_Silent_p.V60V	NM_031216	NP_112493	Q96EE3	SEH1_HUMAN	sec13-like protein isoform 2	60	WD 2.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|carbohydrate metabolic process|cell division|glucose transport|mitotic metaphase plate congression|mitotic prometaphase|mRNA transport|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex					0						GTGGATCTGTATGGCGTGTGA	0.398000													4	83					0	0	0.021553	0	0
CIC	23152	broad.mit.edu	37	19	42798840	42798840	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr19:42798840G>A	uc002otf.1	+	19	4452	c.4412G>A	c.(4411-4413)CGG>CAG	p.R1471Q		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	1471					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				GACCAGCGCCGGGCCCTGGTC	0.612000			T	DUX4	soft tissue sarcoma								33	24					0	0	0.080422	0	0
ZNF347	84671	broad.mit.edu	37	19	53652555	53652555	+	Silent	SNP	G	A	A			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr19:53652555G>A	uc002qbb.1	-	3	150	c.81C>T	c.(79-81)CCC>CCT	p.P27P	ZNF347_uc010eql.1_Silent_p.P27P|ZNF347_uc002qbc.1_Silent_p.P27P	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	27	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		TCCTCTGAGCGGGGTCCAGGC	0.502000													49	45					0	0	0.048971	0	0
ZNF845	91664	broad.mit.edu	37	19	53856702	53856702	+	Missense_Mutation	SNP	G	A	A	rs150688663	by1000genomes	TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr19:53856702G>A	uc010ydv.1	+	4	2891	c.2774G>A	c.(2773-2775)CGT>CAT	p.R925H	ZNF845_uc010ydw.1_Missense_Mutation_p.R925H	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	925	C2H2-type 26.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAAACCTTCCGTCACAATTCA	0.363000													4	43					0	0	0.014758	0	0
LILRA2	11027	broad.mit.edu	37	19	55086389	55086389	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr19:55086389G>A	uc002qgg.3	+	4	633	c.544G>A	c.(544-546)GTG>ATG	p.V182M	LILRA2_uc010ern.2_Missense_Mutation_p.V182M|LILRA2_uc002qgf.2_Missense_Mutation_p.V182M|LILRA2_uc010yfe.1_Missense_Mutation_p.V182M|LILRA2_uc010yff.1_Missense_Mutation_p.V170M|LILRA2_uc010ero.2_Missense_Mutation_p.V170M|LILRA2_uc010yfg.1_Missense_Mutation_p.V182M	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	182	Extracellular (Potential).|Ig-like C2-type 2.				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		CATCTTCTCCGTGGGCCCCGT	0.562000													60	39					0	0	0.048971	0	0
WASH2P	375260	broad.mit.edu	37	2	114355998	114355998	+	Missense_Mutation	SNP	C	G	G			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr2:114355998C>G	uc002tkh.2	+	5	674	c.616C>G	c.(616-618)CAC>GAC	p.H206D	WASH2P_uc002tka.2_RNA|WASH2P_uc002tkb.2_RNA|WASH2P_uc002tkd.2_RNA	NM_182905	NP_878908			WAS protein family homolog 1												0						CCAAGGTGGGCACTTGATGTC	0.612000													2	11					0	0	0.009096	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								38	55					0	0	0.048971	0	0
GLB1L	79411	broad.mit.edu	37	2	220103270	220103270	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr2:220103270G>A	uc002vkm.2	-	13	1413	c.1174C>T	c.(1174-1176)CCC>TCC	p.P392S	GLB1L_uc002vkk.2_Missense_Mutation_p.P149S|GLB1L_uc010zkx.1_Missense_Mutation_p.P302S|GLB1L_uc002vkn.2_Missense_Mutation_p.P392S	NM_024506	NP_078782	Q6UWU2	GLB1L_HUMAN	galactosidase, beta 1-like precursor	392					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds				0		all_lung(227;1.19e-05)|Lung NSC(271;2.76e-05)|Medulloblastoma(418;0.0208)|Esophageal squamous(248;0.0559)		Epithelial(149;1.3e-11)|all cancers(144;2.07e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGCCCACGGGGGCAAAGCAAG	0.448000													35	65					0	0	0.039052	0	0
GGA1	26088	broad.mit.edu	37	22	38014515	38014515	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr22:38014515C>T	uc003atc.2	+	4	630	c.265C>T	c.(265-267)CGC>TGC	p.R89C	GGA1_uc003atd.2_Missense_Mutation_p.R89C|GGA1_uc003ate.2_Missense_Mutation_p.R89C|GGA1_uc003atf.2_Missense_Mutation_p.R16C	NM_013365	NP_037497	Q9UJY5	GGA1_HUMAN	golgi associated, gamma adaptin ear containing,	89	VHS.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|Golgi apparatus part	protein binding			breast(2)|ovary(1)	3	Melanoma(58;0.0574)					GGGCAAGTTCCGCTTTCTCAA	0.617000													4	51					0	0	0.014758	0	0
CELSR1	9620	broad.mit.edu	37	22	46790148	46790148	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr22:46790148G>A	uc003bhw.1	-	14	5855	c.5855C>T	c.(5854-5856)CCG>CTG	p.P1952L	CELSR1_uc011arc.1_Missense_Mutation_p.P273L	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1952	Extracellular (Potential).|EGF-like 7; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity	p.P1952S(1)		lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TCTGGGGCACGGAAGGTCGAG	0.562000													5	44					0	0	0.021553	0	0
ACAD11	84129	broad.mit.edu	37	3	132277850	132277850	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr3:132277850G>A	uc003eov.3	-	20	2688	c.2308C>T	c.(2308-2310)CGG>TGG	p.R770W		NM_032169	NP_115545	Q709F0	ACD11_HUMAN	putative acyl-CoA dehydrogenase	770						peroxisome	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|transferase activity, transferring phosphorus-containing groups			ovary(1)	1						GCTTGGTCCCGCAGCTCCATT	0.463000													3	51					0	0	0.014758	0	0
PIK3CA	5290	broad.mit.edu	37	3	178916645	178916645	+	Missense_Mutation	SNP	G	C	C			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr3:178916645G>C	uc003fjk.2	+	2	189	c.32G>C	c.(31-33)TGG>TCG	p.W11S		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	11					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.L10_M16del(1)|p.E9_R19del(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GGTGAACTGTGGGGCATCCAC	0.403000		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			29	28					0	0	0.064281	0	0
PCDH7	5099	broad.mit.edu	37	4	30725853	30725853	+	Missense_Mutation	SNP	G	C	C			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr4:30725853G>C	uc003gsk.1	+	1	3817	c.2809G>C	c.(2809-2811)GAC>CAC	p.D937H	PCDH7_uc011bxw.1_Missense_Mutation_p.D890H|PCDH7_uc011bxx.1_Missense_Mutation_p.D937H	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	937	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						GCCTAAAAAGGACAAGAAAAA	0.398000													14	34					0	0	0.028581	0	0
GABRA4	2557	broad.mit.edu	37	4	46967171	46967171	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr4:46967171G>A	uc003gxg.2	-	8	1089	c.950C>T	c.(949-951)ACC>ATC	p.T317I		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	317					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GTCCATGGCGGTAGCATAGGA	0.433000													4	145					0	0	0.021553	0	0
OTUD4	54726	broad.mit.edu	37	4	146059006	146059006	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr4:146059006G>A	uc003ika.3	-	21	2864	c.2726C>T	c.(2725-2727)ACT>ATT	p.T909I	OTUD4_uc003ijz.3_Missense_Mutation_p.T908I	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	973							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					AACAGGCACAGTTTCTCTCTC	0.463000													7	163					0	0	0.038147	0	0
BEND3	57673	broad.mit.edu	37	6	107391126	107391126	+	Silent	SNP	G	A	A			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr6:107391126G>A	uc003prs.2	-	5	1919	c.1269C>T	c.(1267-1269)TTC>TTT	p.F423F		NM_001080450	NP_001073919	Q5T5X7	BEND3_HUMAN	BEN domain containing 3	423	BEN 2.									ovary(3)	3						TGCGGTGGTCGAAGAGCTCGG	0.622000													3	60					0	0	0.004672	0	0
EPHX2	2053	broad.mit.edu	37	8	27401706	27401706	+	Missense_Mutation	SNP	C	A	A			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr8:27401706C>A	uc003xfu.2	+	18	1615	c.1534C>A	c.(1534-1536)CCC>ACC	p.P512T	EPHX2_uc010luu.2_Missense_Mutation_p.P480T|EPHX2_uc010luv.2_Missense_Mutation_p.P446T|EPHX2_uc003xfv.2_Missense_Mutation_p.P459T|EPHX2_uc010luw.2_Missense_Mutation_p.P446T	NM_001979	NP_001970	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	512	Epoxide hydrolase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			ovary(1)	1		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	CTTTCAGATTCCCCACCTGAA	0.572000													50	132					1.77791e-30	1.86909e-30	0.048971	1	0
PLIN2	123	broad.mit.edu	37	9	19116570	19116570	+	Silent	SNP	G	A	A			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr9:19116570G>A	uc003zno.2	-	8	1169	c.990C>T	c.(988-990)TCC>TCT	p.S330S	PLIN2_uc011lna.1_Silent_p.S302S	NM_001122	NP_001113	Q99541	PLIN2_HUMAN	adipose differentiation-related protein	330					cellular lipid metabolic process	endoplasmic reticulum|extracellular region|lipid particle				ovary(2)	2						CTTGGATGTTGGACAGGAGGG	0.493000													4	158					0	0	0.021553	0	0
Unknown	0	broad.mit.edu	37	9	68413569	68413569	+	RNA	SNP	C	T	T			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr9:68413569C>T	uc004aex.2	+	1		c.124C>T								Homo sapiens mRNA; cDNA DKFZp564N0763 (from clone DKFZp564N0763).																		CCCCCAGTGGCGCCGGATCTA	0.557000													3	7					0	0	0.014758	0	0
ABCA1	19	broad.mit.edu	37	9	107645364	107645364	+	Missense_Mutation	SNP	C	T	T	rs138438101		TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr9:107645364C>T	uc004bcl.2	-	5	690	c.377G>A	c.(376-378)CGC>CAC	p.R126H	ABCA1_uc004bcm.2_Missense_Mutation_p.R66H	NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	126	Extracellular.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CAGAACTTTGCGCATGTCCTT	0.453000													6	64					0	0	0.021553	0	0
ZBTB40	9923	broad.mit.edu	37	1	22838561	22838563	+	In_Frame_Del	DEL	AAG	-	-			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr1:22838561_22838563delAAG	uc001bft.2	+	12	2906_2908	c.2395_2397delAAG	c.(2395-2397)AAGdel	p.K803del	ZBTB40_uc001bfu.2_In_Frame_Del_p.K803del|ZBTB40_uc009vqi.1_In_Frame_Del_p.K691del|ZBTB40_uc001bfv.1_In_Frame_Del_p.K432del	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	803					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		CGATGCCCCCAAGAAGAAGAAGA	0.517													9	45	---	---	---	---					
LRP1	4035	broad.mit.edu	37	12	57605740	57605742	+	In_Frame_Del	DEL	TGC	-	-			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr12:57605740_57605742delTGC	uc001snd.2	+	87	13755_13757	c.13289_13291delTGC	c.(13288-13293)TTGCTG>TTG	p.4430_4431LL>L		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	4430_4431	Helical; (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCTCTGCTGTTGCTGCTGCTGCT	0.557													8	304	---	---	---	---					
ACE	1636	broad.mit.edu	37	17	61560474	61560474	+	Frame_Shift_Del	DEL	G	-	-			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr17:61560474delG	uc002jau.1	+	9	1449	c.1427delG	c.(1426-1428)TGGfs	p.W476fs	ACE_uc010wpi.1_Intron|ACE_uc010ddu.1_Frame_Shift_Del_p.W293fs|ACE_uc002jav.1_5'Flank|ACE_uc010ddv.1_5'Flank|ACE_uc010wpj.1_5'Flank|ACE_uc002jaw.1_5'Flank|ACE_uc010wpk.1_5'Flank	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	476	Extracellular (Potential).|Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CAGTGGCGCTGGGGGGTCTTT	0.532													8	377	---	---	---	---					
BPTF	2186	broad.mit.edu	37	17	65940454	65940456	+	In_Frame_Del	DEL	CAC	-	-	rs143937013		TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr17:65940454_65940456delCAC	uc002jgf.2	+	20	6727_6729	c.6666_6668delCAC	c.(6664-6669)AGCACC>AGC	p.T2227del	BPTF_uc002jge.2_In_Frame_Del_p.T2353del|BPTF_uc002jgg.2_In_Frame_Del_p.T27del	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	2353	Thr-rich.				brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			CCACAGCCAGCACCACCACCACC	0.542													8	191	---	---	---	---					
CLEC17A	388512	broad.mit.edu	37	19	14694175	14694176	+	In_Frame_Ins	INS	-	GGA	GGA	rs138602183		TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr19:14694175_14694176insGGA	uc010dzn.1	+	2	127_128	c.50_51insGGA	c.(49-51)ATG>ATGGAG	p.22_23insE	CLEC17A_uc002mzh.1_In_Frame_Ins_p.22_23insE|CLEC17A_uc010xnt.1_RNA|CLEC17A_uc010xnu.1_In_Frame_Ins_p.22_23insE|CLEC17A_uc010dzo.1_In_Frame_Ins_p.22_23insE			Q6ZS10	CL17A_HUMAN	SubName: Full=CLEC17A protein;	22_23	Cytoplasmic (Potential).					cell surface|integral to membrane	fucose binding|mannose binding|metal ion binding|receptor activity				0						GAAGGGACCATGGAGGAGGAGG	0.579													4	8	---	---	---	---					
KCNB1	3745	broad.mit.edu	37	20	47989771	47989772	+	Frame_Shift_Ins	INS	-	G	G			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr20:47989771_47989772insG	uc002xur.1	-	2	2489_2490	c.2325_2326insC	c.(2323-2328)CCCAAAfs	p.P775fs	KCNB1_uc002xus.1_Frame_Shift_Ins_p.P775fs	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	775_776	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GGGAGGCTTTTGGGGGGGCTGG	0.545													7	747	---	---	---	---					
ZNF148	7707	broad.mit.edu	37	3	124952387	124952387	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr3:124952387delT	uc003ehx.3	-	9	1669	c.1183delA	c.(1183-1185)ATTfs	p.I395fs	SLC12A8_uc003ehw.3_Intron|ZNF148_uc003ehz.3_Frame_Shift_Del_p.I395fs|ZNF148_uc010hsa.2_Frame_Shift_Del_p.I395fs|ZNF148_uc003eia.3_Frame_Shift_Del_p.I395fs|ZNF148_uc003ehy.2_Intron	NM_021964	NP_068799	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	395					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4						TTACTATTAATTTTTTTGAGA	0.383													46	22	---	---	---	---					
C6orf153	88745	broad.mit.edu	37	6	42989434	42989451	+	In_Frame_Del	DEL	CGGGGCCCGACGTCCCCG	-	-	rs60664426		TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr6:42989434_42989451delCGGGGCCCGACGTCCCCG	uc003otp.1	+	1	50_67	c.42_59delCGGGGCCCGACGTCCCCG	c.(40-60)GCCGGGGCCCGACGTCCCCGC>GCC	p.GARRPR15del		NM_033112	NP_149103	Q96EU6	RRP36_HUMAN	hypothetical protein LOC88745	15_20					ribosomal small subunit biogenesis|rRNA processing	nucleolus					0			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			gggccggggccggggcccgacgtccccgcggggcccgg	0.550													3	5	---	---	---	---					
ABCB4	5244	broad.mit.edu	37	7	87074281	87074282	+	Frame_Shift_Ins	INS	-	A	A			TCGA-FG-7634-01A-11D-2086-08	TCGA-FG-7634-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc668076-5204-4c1b-8591-9ad354c15a6d	a5d74526-2420-4363-859f-becb06afe263	g.chr7:87074281_87074282insA	uc003uiv.1	-	10	1091_1092	c.1015_1016insT	c.(1015-1017)TCAfs	p.S339fs	ABCB4_uc003uiw.1_Frame_Shift_Ins_p.S339fs|ABCB4_uc003uix.1_Frame_Shift_Ins_p.S339fs	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	339	Helical; (By similarity).|ABC transmembrane type-1 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					AATTAGGATTGAAAAAAAAACC	0.347													7	42	---	---	---	---					
