Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ACTL8	81569	broad.mit.edu	37	1	18152414	18152414	+	Silent	SNP	C	T	T	rs114899155	byFrequency	TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr1:18152414C>T	uc001bat.2	+	3	717	c.501C>T	c.(499-501)CCC>CCT	p.P167P		NM_030812	NP_110439	Q9H568	ACTL8_HUMAN	actin-like 8	167						cytoplasm|cytoskeleton				ovary(4)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		GCCCCTTGCCCGCCAGCGGCA	0.607000											OREG0013157	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	40					0	0	0.003080	0	0
EIF4G3	8672	broad.mit.edu	37	1	21268144	21268144	+	Silent	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr1:21268144G>A	uc001bec.2	-	9	1591	c.1335C>T	c.(1333-1335)GCC>GCT	p.A445A	EIF4G3_uc010odi.1_Silent_p.A49A|EIF4G3_uc010odj.1_Silent_p.A444A|EIF4G3_uc009vpz.2_Intron|EIF4G3_uc001bed.2_Silent_p.A445A|EIF4G3_uc001bef.2_Silent_p.A444A|EIF4G3_uc001bee.2_Silent_p.A451A|EIF4G3_uc001beg.2_Silent_p.A444A|EIF4G3_uc010odk.1_Silent_p.A445A|EIF4G3_uc001beh.2_Silent_p.A456A	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	445					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		GGACTGTGATGGCAGCACTCG	0.363000													11	201					0	0	0.013537	0	0
CDC20	991	broad.mit.edu	37	1	43826262	43826262	+	Silent	SNP	C	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr1:43826262C>A	uc001cix.2	+	7	947	c.846C>A	c.(844-846)TCC>TCA	p.S282S	CDC20_uc001ciy.2_Silent_p.S282S	NM_001255	NP_001246	Q12834	CDC20_HUMAN	cell division cycle 20	282	WD 3.				activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	cytosol|nucleoplasm|spindle	enzyme binding|protein C-terminus binding				0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ATATCCTGTCCAGGTCAGTGG	0.512000													6	108					2.7689e-08	3.03772e-08	0.001984	1	0
CCDC19	25790	broad.mit.edu	37	1	159842876	159842876	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr1:159842876G>A	uc001fui.2	-	11	1453	c.1435C>T	c.(1435-1437)CGG>TGG	p.R479W	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_Missense_Mutation_p.R394W|CCDC19_uc001ful.2_Missense_Mutation_p.R394W	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	479	Potential.					mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			ACCTGGCGCCGGAGCTCATTG	0.612000													18	68					0	0	0.012319	0	0
HMCN1	83872	broad.mit.edu	37	1	185947027	185947027	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr1:185947027G>A	uc001grq.1	+	16	2709	c.2480G>A	c.(2479-2481)CGA>CAA	p.R827Q	HMCN1_uc001grr.1_Missense_Mutation_p.R168Q	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	827	Ig-like C2-type 5.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ATCAAATGGCGAAGATTAGAC	0.378000													13	91					0	0	0.013537	0	0
CACNA1S	779	broad.mit.edu	37	1	201020210	201020210	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr1:201020210C>T	uc001gvv.2	-	33	4242	c.4015G>A	c.(4015-4017)GAC>AAC	p.D1339N		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1339	Extracellular (Potential).|Dihydropyridine binding (By similarity).|IV.				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GACTCTGGGTCACACAGCTTC	0.547000													6	118					0	0	0.004482	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37430948	37430948	+	Missense_Mutation	SNP	C	G	G			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr10:37430948C>G	uc001iza.1	+	7	1054	c.955C>G	c.(955-957)CCA>GCA	p.P319A		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	375						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						ATTTACGTGGCCAGCAAAAGG	0.423000													3	88					0	0	0.009096	0	0
RTKN2	219790	broad.mit.edu	37	10	63957831	63957831	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr10:63957831T>C	uc001jlw.2	-	12	1763	c.1666A>G	c.(1666-1668)ATG>GTG	p.M556V	RTKN2_uc009xpf.1_Intron|RTKN2_uc001jlv.2_Missense_Mutation_p.M210V	NM_145307	NP_660350	Q8IZC4	RTKN2_HUMAN	rhotekin 2	556					signal transduction	intracellular					0	Prostate(12;0.0297)|all_hematologic(501;0.215)					GGAGCAGCCATTGGTTTCTGT	0.428000													15	75					0	0	0.006122	0	0
PLEKHA1	59338	broad.mit.edu	37	10	124157455	124157455	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr10:124157455C>T	uc001lge.1	+	3	286	c.163C>T	c.(163-165)CGT>TGT	p.R55C	PLEKHA1_uc001lgf.1_Missense_Mutation_p.R55C|PLEKHA1_uc001lgg.1_Missense_Mutation_p.R55C|PLEKHA1_uc001lgh.2_Missense_Mutation_p.R55C	NM_001001974	NP_001001974	Q9HB21	PKHA1_HUMAN	pleckstrin homology domain containing, family A	55	PH 1.				B cell receptor signaling pathway|cellular response to hydrogen peroxide|establishment of protein localization|negative regulation of protein kinase B signaling cascade|phosphatidylinositol 3-kinase cascade|ruffle organization	cytoplasm|nucleus|ruffle membrane	PDZ domain binding|phosphatidylinositol-3,4-bisphosphate binding			kidney(1)	1		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGGATCATCACGTGTTGGAGC	0.299000													16	66					0	0	0.010504	0	0
EBF3	253738	broad.mit.edu	37	10	131761728	131761728	+	Missense_Mutation	SNP	G	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr10:131761728G>T	uc001lki.1	-	2	253	c.194C>A	c.(193-195)TCC>TAC	p.S65Y	EBF3_uc010qur.1_Missense_Mutation_p.S51Y	NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	65	Interaction with DNA (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		GAAGAAATTGGATTTCCGGAG	0.577000													8	59					0.000673444	0.000711207	0.008291	1	0
NLRP6	171389	broad.mit.edu	37	11	281299	281299	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr11:281299C>T	uc010qvs.1	+	4	1565	c.1565C>T	c.(1564-1566)GCG>GTG	p.A522V	NLRP6_uc010qvt.1_Missense_Mutation_p.A522V	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	522						cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		CCCAGGACCGCGGCTGGCGGC	0.677000													5	21					0	0	0.021553	0	0
ZNF195	7748	broad.mit.edu	37	11	3380510	3380510	+	Silent	SNP	T	C	C			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr11:3380510T>C	uc001lxt.2	-	6	1906	c.1728A>G	c.(1726-1728)AAA>AAG	p.K576K	uc001lxr.2_5'Flank|ZNF195_uc001lxv.2_Silent_p.K553K|ZNF195_uc001lxs.2_Silent_p.K504K|ZNF195_uc010qxr.1_Silent_p.K557K|ZNF195_uc009ydz.2_Silent_p.K531K|ZNF195_uc001lxu.2_Silent_p.K508K	NM_001130520	NP_001123992	O14628	ZN195_HUMAN	zinc finger protein 195 isoform 1	576					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		ATTTGTAGGGTTTCTCTCCAG	0.393000													3	118					0	0	0.009096	0	0
OR52M1	119772	broad.mit.edu	37	11	4567000	4567000	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr11:4567000G>A	uc010qyf.1	+	1	580	c.580G>A	c.(580-582)GAC>AAC	p.D194N		NM_001004137	NP_001004137	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M,	194	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		GACATGTGGCGACAGCAGGGT	0.512000													31	181					0	0	0.021022	0	0
OR51E1	143503	broad.mit.edu	37	11	4674486	4674486	+	Missense_Mutation	SNP	G	A	A	rs148787592		TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr11:4674486G>A	uc001lzi.3	+	2	874	c.730G>A	c.(730-732)GTC>ATC	p.V244I		NM_152430	NP_689643	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E,	243	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V243I(1)		large_intestine(3)|pancreas(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGCACTTGCGTCTCTCATGT	0.498000													13	75					0	0	0.020292	0	0
COMMD9	29099	broad.mit.edu	37	11	36296235	36296235	+	Missense_Mutation	SNP	A	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr11:36296235A>T	uc001mwn.3	-	6	581	c.544T>A	c.(544-546)TTA>ATA	p.L182I	COMMD9_uc009ykj.2_Missense_Mutation_p.L140I|COMMD9_uc009yki.1_5'Flank	NM_014186	NP_054905	Q9P000	COMD9_HUMAN	COMM domain containing 9 isoform 1	182	COMM.									ovary(1)	1	all_lung(20;0.211)	all_hematologic(20;0.107)				AGGCCATCTAACATGGTGTCC	0.562000													4	141					0	0	0.009096	0	0
PTPRJ	5795	broad.mit.edu	37	11	48157649	48157649	+	Silent	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr11:48157649G>A	uc001ngp.3	+	9	2029	c.1674G>A	c.(1672-1674)CTG>CTA	p.L558L	PTPRJ_uc010rhr.1_Silent_p.L3L	NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	558	Extracellular (Potential).|Fibronectin type-III 6.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						AGATGTGGCTGGACTGGAAGA	0.493000													3	104					0	0	0.004672	0	0
OR5D18	219438	broad.mit.edu	37	11	55587486	55587486	+	Silent	SNP	T	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr11:55587486T>A	uc010rin.1	+	1	381	c.381T>A	c.(379-381)ATT>ATA	p.I127I		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	127	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				TCGTGGCCATTTGCAACCCTC	0.463000													24	159					0	0	0.021523	0	0
AHNAK	79026	broad.mit.edu	37	11	62296070	62296070	+	Missense_Mutation	SNP	A	G	G			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr11:62296070A>G	uc001ntl.2	-	5	6119	c.5819T>C	c.(5818-5820)GTG>GCG	p.V1940A	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1940					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CGACACATCCACATCCCCTTT	0.502000													6	377					0	0	0.021553	0	0
ROM1	6094	broad.mit.edu	37	11	62381890	62381890	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr11:62381890C>T	uc001ntv.2	+	2	1292	c.751C>T	c.(751-753)CAA>TAA	p.Q251*	EML3_uc001ntr.1_5'Flank|EML3_uc001nts.1_5'Flank|EML3_uc001ntt.1_5'Flank|EML3_uc001ntu.1_5'Flank|EML3_uc010rly.1_5'Flank	NM_000327	NP_000318	Q03395	ROM1_HUMAN	retinal outer segment membrane protein 1	251	Lumenal (Potential).				cell adhesion|visual perception	integral to plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						CCTCTGGGCCCAAGGGTGCCA	0.602000													19	94					0	0	0.012319	0	0
SLC22A12	116085	broad.mit.edu	37	11	64367294	64367294	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr11:64367294G>A	uc001oam.1	+	7	1964	c.1217G>A	c.(1216-1218)CGC>CAC	p.R406H	SLC22A12_uc001oal.1_Missense_Mutation_p.R185H|SLC22A12_uc009yps.1_Missense_Mutation_p.R372H|SLC22A12_uc001oan.1_Missense_Mutation_p.R298H|SLC22A12_uc009ypt.2_Missense_Mutation_p.R224H	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	406					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						CTGGGCCGCCGCCCCACGCTG	0.642000													4	90					0	0	0.009096	0	0
TMEM151A	256472	broad.mit.edu	37	11	66063102	66063102	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr11:66063102G>A	uc001ohl.2	+	2	1497	c.1385G>A	c.(1384-1386)GGG>GAG	p.G462E		NM_153266	NP_694998	Q8N4L1	T151A_HUMAN	transmembrane protein 151A	462						integral to membrane				central_nervous_system(1)	1						GGCTGCCAGGGGGATGGGCAG	0.657000													3	27					0	0	0.001984	0	0
KRTAP5-8	57830	broad.mit.edu	37	11	71249545	71249545	+	Silent	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr11:71249545C>T	uc001oqr.1	+	1	475	c.444C>T	c.(442-444)TGC>TGT	p.C148C		NM_021046	NP_066384	O75690	KRA58_HUMAN	keratin associated protein 5-8	148	9 X 4 AA repeats of C-C-X-P.|7.					extracellular region|keratin filament	structural constituent of epidermis				0						AGTCCAGCTGCTGTAAGCCCT	0.607000													6	504					0	0	0.004482	0	0
SLC6A13	6540	broad.mit.edu	37	12	346452	346452	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr12:346452G>A	uc001qic.1	-	6	621	c.568C>T	c.(568-570)CGG>TGG	p.R190W	SLC6A13_uc009zdj.1_Missense_Mutation_p.R190W|SLC6A13_uc010sdl.1_Missense_Mutation_p.R98W|SLC6A13_uc010sdm.1_Missense_Mutation_p.R71W	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	190	Extracellular (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			TTCAAGACCCGCCGCCTGGGG	0.617000													4	86					0	0	0.014758	0	0
TAS2R8	50836	broad.mit.edu	37	12	10959421	10959421	+	Silent	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr12:10959421G>A	uc010shh.1	-	1	159	c.159C>T	c.(157-159)ATC>ATT	p.I53I		NM_023918	NP_076407	Q9NYW2	TA2R8_HUMAN	taste receptor, type 2, member 8	53	Helical; Name=2; (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			ovary(2)	2						AAATTCTGGCGATAACTAAAT	0.328000													19	137					0	0	0.021523	0	0
GRIN2B	2904	broad.mit.edu	37	12	13716623	13716623	+	Silent	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr12:13716623C>T	uc001rbt.2	-	13	3728	c.3549G>A	c.(3547-3549)ACG>ACA	p.T1183T		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1183	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GTTTGTCGCCCGTCCCGTGCT	0.617000													7	150					0	0	0.008291	0	0
GRIN2B	2904	broad.mit.edu	37	12	13906702	13906702	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr12:13906702G>A	uc001rbt.2	-	3	738	c.559C>T	c.(559-561)CGC>TGC	p.R187C		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	187	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATGGTGCTGCGGATCTTGTTT	0.473000													8	124					0	0	0.004482	0	0
HDAC7	51564	broad.mit.edu	37	12	48191939	48191939	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr12:48191939G>A	uc009zkv.1	-	3	511	c.296C>T	c.(295-297)GCG>GTG	p.A99V	HDAC7_uc010slo.1_Missense_Mutation_p.A138V|HDAC7_uc001rqj.3_Missense_Mutation_p.A138V|HDAC7_uc001rqk.3_Missense_Mutation_p.A121V			Q8WUI4	HDAC7_HUMAN	Synthetic construct DNA, clone: pF1KB0470, Homo sapiens HDAC7 gene for histone deacetylase 7, without stop codon, in Flexi system.	99	Interaction with MEF2A (By similarity).|Transcription repression 1 (By similarity).				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.137)		TTCTAGGGCCGCCTGCTGTTT	0.612000													5	456					0	0	0.003080	0	0
C12orf63	374467	broad.mit.edu	37	12	97082742	97082742	+	Silent	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr12:97082742G>A	uc001tet.1	+	10	1416	c.1338G>A	c.(1336-1338)TTG>TTA	p.L446L		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	446										skin(6)|ovary(1)	7						GTTGCATTTTGTCTGCGTTAC	0.274000													18	113					0	0	0.016522	0	0
LOC284232	284232	broad.mit.edu	37	13	19415677	19415677	+	RNA	SNP	A	T	T	rs142136612	by1000genomes	TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr13:19415677A>T	uc010tcj.1	-	1		c.30433T>A				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						AACACACTGCAATAGGCTTAC	0.239000													3	57					0	0	0.014758	0	0
LTBP2	4053	broad.mit.edu	37	14	75017918	75017918	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr14:75017918G>A	uc001xqa.2	-	7	1922	c.1535C>T	c.(1534-1536)CCG>CTG	p.P512L		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	512					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CAGCCAGGGCGGGGGTCTGGT	0.706000													5	40					0	0	0.014758	0	0
C15orf54	400360	broad.mit.edu	37	15	39544388	39544388	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr15:39544388G>A	uc001zkg.2	+	2	420	c.52G>A	c.(52-54)GCT>ACT	p.A18T		NM_207445	NP_997328	Q8N8G6	CO054_HUMAN	hypothetical protein LOC400360	18											0		all_cancers(109;5.39e-14)|all_epithelial(112;3.14e-12)|Lung NSC(122;9.74e-10)|all_lung(180;2.23e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;1.19e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0706)		ACCCCAGAGGGCTGAGCCGCA	0.468000													18	306					0	0	0.007413	0	0
TPM1	7168	broad.mit.edu	37	15	63362113	63362113	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr15:63362113G>A	uc002alr.2	+	8	848	c.709G>A	c.(709-711)GAA>AAA	p.E237K	TPM1_uc010bgn.2_Intron|TPM1_uc002ali.2_Intron|TPM1_uc002alj.2_Intron|TPM1_uc002alk.2_Intron|TPM1_uc002all.2_Intron|TPM1_uc002alm.2_Intron|TPM1_uc002als.2_Missense_Mutation_p.E237K|TPM1_uc010uig.1_Intron|TPM1_uc002alt.2_Intron|TPM1_uc010bgp.2_Intron	NM_001018020	NP_001018020	P09493	TPM1_HUMAN	tropomyosin 1 alpha chain isoform 7	273	By similarity.				cardiac muscle contraction|cellular component movement|cellular response to reactive oxygen species|muscle filament sliding|negative regulation of cell migration|positive regulation of ATPase activity|positive regulation of cell adhesion|positive regulation of heart rate by epinephrine|positive regulation of stress fiber assembly|regulation of muscle contraction|ruffle organization|sarcomere organization|ventricular cardiac muscle tissue morphogenesis|wound healing	bleb|cytosol|muscle thin filament tropomyosin|ruffle membrane|stress fiber	actin binding|structural constituent of cytoskeleton|structural constituent of muscle				0						CCTCACTAATGAACTAAAGCT	0.458000													6	91					0	0	0.021553	0	0
Unknown	0	broad.mit.edu	37	15	76073206	76073206	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr15:76073206G>A	uc010umm.1	+	6	495	c.418G>A	c.(418-420)GAA>AAA	p.E140K	uc002bba.1_5'Flank					SubName: Full=cDNA FLJ59077, highly similar to Golgin subfamily A member 6;																		CCGACACTTCGAAGGTGGGAA	0.502000													5	101					0	0	0.021553	0	0
IL16	3603	broad.mit.edu	37	15	81592440	81592440	+	Missense_Mutation	SNP	C	G	G			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr15:81592440C>G	uc002bgh.3	+	14	3149	c.2773C>G	c.(2773-2775)CCA>GCA	p.P925A	IL16_uc010blq.1_Missense_Mutation_p.P879A|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.P967A|IL16_uc002bgg.2_Missense_Mutation_p.P925A|IL16_uc002bgi.1_Missense_Mutation_p.P315A|IL16_uc002bgj.2_Missense_Mutation_p.P419A|IL16_uc002bgk.2_Missense_Mutation_p.P224A|IL16_uc002bgl.1_Missense_Mutation_p.P224A|IL16_uc010unq.1_Missense_Mutation_p.P224A	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	925					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						GTCCCCTCCCCCAGGGCGGCA	0.642000													11	70					0	0	0.020292	0	0
FAM169B	283777	broad.mit.edu	37	15	99023868	99023868	+	Missense_Mutation	SNP	G	A	A	rs141122936	by1000genomes	TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr15:99023868G>A	uc002buk.1	-	4	395	c.145C>T	c.(145-147)CGT>TGT	p.R49C		NM_182562	NP_872368	Q8N8A8	F169B_HUMAN	hypothetical protein LOC283777	49											0						GCCGCTCCACGTCTCCACAGG	0.473000													9	131					0	0	0.016723	0	0
DUS2L	54920	broad.mit.edu	37	16	68100526	68100526	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr16:68100526G>A	uc002evi.2	+	10	690	c.541G>A	c.(541-543)GCA>ACA	p.A181T	DUS2L_uc002evj.2_Missense_Mutation_p.A181T|DUS2L_uc010vkk.1_Missense_Mutation_p.A146T|DUS2L_uc010cez.2_Missense_Mutation_p.A94T	NM_017803	NP_060273	Q9NX74	DUS2L_HUMAN	dihydrouridine synthase 2-like, SMM1 homolog	181					tRNA processing	endoplasmic reticulum	double-stranded RNA binding|flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0131)|Epithelial(162;0.0564)		TGCTGCCATCGCAGTTCATGG	0.517000													5	227					0	0	0.021553	0	0
HYDIN	54768	broad.mit.edu	37	16	70928359	70928359	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr16:70928359C>T	uc002ezr.2	-	55	9366	c.9238G>A	c.(9238-9240)GCG>ACG	p.A3080T		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3081										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				TACCTGAACGCGATCTCATAT	0.527000													3	42					0	0	0.004482	0	0
LOC283922	283922	broad.mit.edu	37	16	74372644	74372644	+	Silent	SNP	A	G	G			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr16:74372644A>G	uc002fcr.2	-	9	1661	c.315T>C	c.(313-315)CCT>CCC	p.P105P	LOC283922_uc010vms.1_RNA					Homo sapiens cDNA FLJ39449 fis, clone PROST2008360, highly similar to Homo sapiens pyruvate dehydrogenase phosphatase regulatory subunit (PDPR), mRNA.												0						TACCCTTGTCAGGGGGAACAA	0.443000													4	35					0	0	0.009096	0	0
Unknown	0	broad.mit.edu	37	17	21730916	21730916	+	Missense_Mutation	SNP	G	T	T	rs111245273	by1000genomes	TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr17:21730916G>T	uc002gyy.3	+	2	343	c.218G>T	c.(217-219)CGG>CTG	p.R73L						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;																		GTCCTGCGTCGGAGAGGTGGT	0.552000													3	85					0.000602214	0.000641983	0.014758	1	0
Unknown	0	broad.mit.edu	37	17	21731352	21731352	+	Silent	SNP	C	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr17:21731352C>A	uc002gyy.3	+	2	779	c.654C>A	c.(652-654)CCC>CCA	p.P218P						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;																		GGAGTCGACCCTGCACCTGGT	0.552000													15	84					5.26018e-13	6.00404e-13	0.012319	1	0
KRT27	342574	broad.mit.edu	37	17	38933849	38933849	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr17:38933849C>T	uc002hvg.2	-	6	1149	c.1108G>A	c.(1108-1110)GAG>AAG	p.E370K		NM_181537	NP_853515	Q7Z3Y8	K1C27_HUMAN	keratin 27	370	Rod.|Coil 2.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.000812)				TGCTCATACTCGAGCTTCTGG	0.547000													31	220					0	0	0.012213	0	0
Unknown	0	broad.mit.edu	37	17	45105705	45105705	+	RNA	SNP	A	G	G	rs147936028	by1000genomes	TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr17:45105705A>G	uc010wki.1	+	5		c.1307A>G								Homo sapiens cDNA FLJ42521 fis, clone BRACE3000973.																		GCCTGGCACGAAATGCAGTTT	0.303000													7	223					0	0	0.001984	0	0
MAP3K3	4215	broad.mit.edu	37	17	61765935	61765935	+	Silent	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr17:61765935C>T	uc002jbg.2	+	9	1078	c.759C>T	c.(757-759)GAC>GAT	p.D253D	MAP3K3_uc002jbe.2_Silent_p.D284D|MAP3K3_uc002jbf.2_Silent_p.D284D|MAP3K3_uc002jbh.2_Silent_p.D280D|MAP3K3_uc010wpo.1_Silent_p.D168D|MAP3K3_uc010wpp.1_Silent_p.D249D	NM_002401	NP_002392	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	253					MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			lung(3)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)	6						GCTTCCCTGACAACAGACAGG	0.537000													10	70					0	0	0.028581	0	0
CD300E	342510	broad.mit.edu	37	17	72613303	72613303	+	Silent	SNP	T	C	C			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr17:72613303T>C	uc002jlb.1	-	2	383	c.342A>G	c.(340-342)TCA>TCG	p.S114S		NM_181449	NP_852114	Q496F6	CLM2_HUMAN	CD300e molecule precursor	114	Ig-like V-type.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						CGCGTGACCATGAATCCAGGA	0.547000													6	163					0	0	0.003080	0	0
CANT1	124583	broad.mit.edu	37	17	76993313	76993313	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr17:76993313T>C	uc002jwn.2	-	4	831	c.392A>G	c.(391-393)AAG>AGG	p.K131R	CANT1_uc002jwk.2_Missense_Mutation_p.K131R|CANT1_uc002jwj.2_Missense_Mutation_p.K131R|CANT1_uc002jwl.2_RNA|CANT1_uc002jwm.1_5'Flank	NM_001159772	NP_001153244	Q8WVQ1	CANT1_HUMAN	calcium activated nucleotidase 1	131	Lumenal (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to membrane	calcium ion binding|nucleoside-diphosphatase activity|signal transducer activity				0			BRCA - Breast invasive adenocarcinoma(99;0.0362)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			CAGGTAGCCCTTTTTCAGGTA	0.577000			T	ETV4	prostate								4	369					0	0	0.001984	0	0
DSG2	1829	broad.mit.edu	37	18	29125858	29125858	+	Missense_Mutation	SNP	G	C	C			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr18:29125858G>C	uc002kwu.3	+	15	2697	c.2509G>C	c.(2509-2511)GCT>CCT	p.A837P	uc002kwv.3_RNA	NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	837	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			CAAGACACTAGCTGAAGTTTG	0.378000													3	110					0	0	0.004672	0	0
NOTCH3	4854	broad.mit.edu	37	19	15271630	15271630	+	Missense_Mutation	SNP	G	A	A	rs148716935		TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr19:15271630G>A	uc002nan.2	-	33	6885	c.6809C>T	c.(6808-6810)ACG>ATG	p.T2270M		NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	2270	Cytoplasmic (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			TGGGCTAGGCGTGGATTCGGA	0.667000													6	109					0	0	0.001984	0	0
ZNF430	80264	broad.mit.edu	37	19	21240178	21240178	+	Missense_Mutation	SNP	A	G	G			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr19:21240178A>G	uc002npj.2	+	5	1174	c.1064A>G	c.(1063-1065)AAC>AGC	p.N355S	ZNF430_uc002npk.2_Missense_Mutation_p.N354S	NM_025189	NP_079465	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	355	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2						AAAGCTTTTAACCAATCCTCA	0.388000													3	168					0	0	0.004672	0	0
ZNF430	80264	broad.mit.edu	37	19	21240182	21240182	+	Silent	SNP	A	G	G			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr19:21240182A>G	uc002npj.2	+	5	1178	c.1068A>G	c.(1066-1068)CAA>CAG	p.Q356Q	ZNF430_uc002npk.2_Silent_p.Q355Q	NM_025189	NP_079465	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	356	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2						CTTTTAACCAATCCTCAACCC	0.383000													3	161					0	0	0.004672	0	0
PEG3	5178	broad.mit.edu	37	19	57325730	57325730	+	Missense_Mutation	SNP	T	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr19:57325730T>A	uc002qnu.2	-	7	4431	c.4080A>T	c.(4078-4080)GAA>GAT	p.E1360D	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.E1331D|PEG3_uc002qnv.2_Missense_Mutation_p.E1360D|PEG3_uc002qnw.2_Missense_Mutation_p.E1236D|PEG3_uc002qnx.2_Missense_Mutation_p.E1234D|PEG3_uc010etr.2_Missense_Mutation_p.E1360D	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1360	Glu-rich.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ctgctTCATCTTCTTCTTCTT	0.363000													3	52					0	0	0.004672	0	0
TTN	7273	broad.mit.edu	37	2	179414390	179414390	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr2:179414390C>T	uc010zfg.1	-	287	84579	c.84355G>A	c.(84355-84357)GGC>AGC	p.G28119S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G21814S|TTN_uc010zfi.1_Missense_Mutation_p.G21747S|TTN_uc010zfj.1_Missense_Mutation_p.G21622S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29046							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTCATTGCCGTTTATTAGT	0.408000													5	84					0	0	0.021553	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187698677	187698677	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr2:187698677C>T	uc002upu.1	-	6	864	c.824G>A	c.(823-825)CGT>CAT	p.R275H		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	275	ZZ-type.				apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			CTGTACCTCACGAAATGTAAA	0.363000													13	60					0	0	0.028581	0	0
CXCR1	3577	broad.mit.edu	37	2	219029298	219029298	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr2:219029298C>T	uc002vhc.2	-	2	756	c.637G>A	c.(637-639)GTG>ATG	p.V213M		NM_000634	NP_000625	P25024	CXCR1_HUMAN	interleukin 8 receptor alpha	213	Helical; Name=5; (Potential).				dendritic cell chemotaxis|inflammatory response	integral to membrane|plasma membrane	interleukin-8 receptor activity			lung(2)	2						AACAGCGGCACGATGAAGCCA	0.522000													10	114					0	0	0.006214	0	0
PTPN1	5770	broad.mit.edu	37	20	49195082	49195082	+	Silent	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr20:49195082G>A	uc002xvl.2	+	6	792	c.618G>A	c.(616-618)CCG>CCA	p.P206P	PTPN1_uc010zys.1_Silent_p.P133P	NM_002827	NP_002818	P18031	PTN1_HUMAN	protein tyrosine phosphatase, non-receptor type	206	Tyrosine-protein phosphatase.				blood coagulation|interferon-gamma-mediated signaling pathway|negative regulation of insulin receptor signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol|endoplasmic reticulum membrane	protein tyrosine phosphatase activity|zinc ion binding				0		Lung NSC(126;0.163)			Clodronate(DB00720)|Tiludronate(DB01133)	CACTCAGCCCGGAGCACGGGC	0.557000													4	118					0	0	0.009096	0	0
ZNF831	128611	broad.mit.edu	37	20	57766794	57766794	+	Silent	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr20:57766794C>T	uc002yan.2	+	1	720	c.720C>T	c.(718-720)GGC>GGT	p.G240G		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	240						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TGCACGAAGGCGCCTCGGAGA	0.687000													10	41					0	0	0.016723	0	0
RTEL1	51750	broad.mit.edu	37	20	62324212	62324212	+	Missense_Mutation	SNP	G	A	A	rs143317975		TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr20:62324212G>A	uc002yfu.1	+	29	3050	c.2707G>A	c.(2707-2709)GTG>ATG	p.V903M	RTEL1_uc011abc.1_RNA|RTEL1_uc002yft.1_Missense_Mutation_p.V903M|RTEL1_uc011abd.1_Missense_Mutation_p.V927M|RTEL1_uc011abe.1_Missense_Mutation_p.V680M|RTEL1_uc002yfw.2_RNA|RTEL1_uc002yfx.1_Missense_Mutation_p.V148M|TNFRSF6B_uc002yfy.2_5'Flank	NM_016434	NP_057518	Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	903					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding				0	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			CATGGTGGCCGTGAAGCAGGA	0.642000													4	131					0	0	0.021553	0	0
CYYR1	116159	broad.mit.edu	37	21	27852702	27852702	+	Missense_Mutation	SNP	C	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr21:27852702C>A	uc002ymd.2	-	3	545	c.223G>T	c.(223-225)GGG>TGG	p.G75W	CYYR1_uc011ack.1_RNA|CYYR1_uc002yme.2_Missense_Mutation_p.G75W	NM_052954	NP_443186	Q96J86	CYYR1_HUMAN	cysteine and tyrosine-rich 1 protein precursor	75	Helical; (Potential).					integral to membrane					0						GCAATGACCCCCATGATAAAT	0.463000													7	146					2.52707e-12	2.85559e-12	0.006214	1	0
TRIOBP	11078	broad.mit.edu	37	22	38120282	38120282	+	Silent	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr22:38120282C>T	uc003atr.2	+	7	1990	c.1719C>T	c.(1717-1719)GAC>GAT	p.D573D	TRIOBP_uc003atu.2_Silent_p.D401D|TRIOBP_uc003atq.1_Silent_p.D573D|TRIOBP_uc003ats.1_Silent_p.D401D	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	573					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					CCACACGAGACAACCCCAGAA	0.587000													5	249					0	0	0.014758	0	0
PCBP4	57060	broad.mit.edu	37	3	51993277	51993277	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr3:51993277G>A	uc003dcd.1	-	9	1064	c.668C>T	c.(667-669)GCG>GTG	p.A223V	PCBP4_uc003dcb.1_Missense_Mutation_p.A189V|PCBP4_uc003dcc.1_Missense_Mutation_p.A244V|PCBP4_uc003dce.1_Silent_p.C224C|PCBP4_uc003dcf.1_Missense_Mutation_p.A223V|PCBP4_uc003dcg.1_Missense_Mutation_p.A189V|PCBP4_uc003dch.1_Missense_Mutation_p.A223V|PCBP4_uc003dci.1_Missense_Mutation_p.A63V|PCBP4_uc003dcj.1_Missense_Mutation_p.A223V|PCBP4_uc003dck.1_Missense_Mutation_p.A180V|PCBP4_uc003dcl.1_Missense_Mutation_p.A223V	NM_033010	NP_127503	P57723	PCBP4_HUMAN	poly(rC) binding protein 4 isoform c	223						cytoplasm|ribonucleoprotein complex	DNA binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		AAAGGGGACCGCATGGCTTGA	0.637000													3	50					0	0	0.009096	0	0
C3orf14	57415	broad.mit.edu	37	3	62317051	62317051	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr3:62317051C>T	uc003dlf.2	+	5	373	c.229C>T	c.(229-231)CGG>TGG	p.R77W	C3orf14_uc010hnq.2_Missense_Mutation_p.R77W|C3orf14_uc003dlg.2_Missense_Mutation_p.R77W	NM_020685	NP_065736	Q9HBI5	CC014_HUMAN	hypothetical protein LOC57415	77										central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.00023)|KIRC - Kidney renal clear cell carcinoma(15;0.00877)|Kidney(15;0.0101)		CCCACTTCCACGGCCTGAGGT	0.388000													17	102					0	0	0.012319	0	0
FAM86D	692099	broad.mit.edu	37	3	75476630	75476630	+	Silent	SNP	T	G	G			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr3:75476630T>G	uc003dpp.3	-	6	794	c.435A>C	c.(433-435)GTA>GTC	p.V145V	FAM86D_uc003dpo.3_Intron|FAM86D_uc003dps.3_Intron|FAM86D_uc003dpq.3_Silent_p.V53V|FAM86D_uc003dpr.3_Intron	NR_024241				RecName: Full=Protein FAM86B1;												0						GGACCGTCGCTACGTCCCAGT	0.582000													8	55					0	0	0.008291	0	0
EPHA6	285220	broad.mit.edu	37	3	97329663	97329663	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr3:97329663T>C	uc010how.1	+	13	2582	c.2539T>C	c.(2539-2541)TAT>CAT	p.Y847H	EPHA6_uc011bgo.1_RNA|EPHA6_uc011bgp.1_Missense_Mutation_p.Y213H|EPHA6_uc003drs.3_Missense_Mutation_p.Y239H|EPHA6_uc003drr.3_Missense_Mutation_p.Y239H|EPHA6_uc003drt.2_Missense_Mutation_p.Y239H|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	752	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						TGTGGTGGAATATATGGAGAA	0.373000													6	112					0	0	0.003080	0	0
ZNF721	170960	broad.mit.edu	37	4	435639	435639	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr4:435639T>C	uc003gag.2	-	3	3308	c.2617A>G	c.(2617-2619)ACC>GCC	p.T873A	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Missense_Mutation_p.T905A|ZNF721_uc010ibe.2_Missense_Mutation_p.T861A	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	873						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TGTCTAAAGGTTTTGCCACAT	0.418000													3	72					0	0	0.004672	0	0
ZNF721	170960	broad.mit.edu	37	4	435653	435653	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr4:435653C>T	uc003gag.2	-	3	3294	c.2603G>A	c.(2602-2604)GGA>GAA	p.G868E	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Missense_Mutation_p.G900E|ZNF721_uc010ibe.2_Missense_Mutation_p.G856E	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	868						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						GCCACATTCTCCACATGTGTA	0.418000													3	78					0	0	0.004672	0	0
WDR1	9948	broad.mit.edu	37	4	10077032	10077032	+	Silent	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr4:10077032G>A	uc003gmf.2	-	15	2074	c.1791C>T	c.(1789-1791)GCC>GCT	p.A597A	WDR1_uc003gmg.2_Silent_p.A457A|WDR1_uc010idm.2_RNA	NM_017491	NP_059830	O75083	WDR1_HUMAN	WD repeat-containing protein 1 isoform 1	597	WD 11.				platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		CCTTGACAGAGGCATCATGGG	0.567000													7	53					0	0	0.004482	0	0
GABRG1	2565	broad.mit.edu	37	4	46060562	46060562	+	Silent	SNP	A	G	G			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr4:46060562A>G	uc003gxb.2	-	6	855	c.703T>C	c.(703-705)TTA>CTA	p.L235L		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	235	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		AACTGATATAATCTCCAGTAT	0.348000													10	69					0	0	0.008291	0	0
POLR2B	5431	broad.mit.edu	37	4	57873149	57873149	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr4:57873149C>T	uc003hcl.1	+	10	1428	c.1385C>T	c.(1384-1386)GCC>GTC	p.A462V	POLR2B_uc011cae.1_Missense_Mutation_p.A455V|POLR2B_uc011caf.1_Missense_Mutation_p.A387V|POLR2B_uc003hcm.1_5'Flank	NM_000938	NP_000929	P30876	RPB2_HUMAN	DNA directed RNA polymerase II polypeptide B	462					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(2)	2	Glioma(25;0.08)|all_neural(26;0.181)					GCTCATCAAGCCAGAGCTGGA	0.378000													10	58					0	0	0.010729	0	0
CCDC158	339965	broad.mit.edu	37	4	77255306	77255306	+	Silent	SNP	A	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr4:77255306A>T	uc003hkb.3	-	18	2832	c.2679T>A	c.(2677-2679)GCT>GCA	p.A893A		NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	893										skin(3)|ovary(2)|pancreas(1)	6						TCAGTGTGTTAGCTTTTGTAG	0.338000													5	69					0	0	0.001984	0	0
KLHL8	57563	broad.mit.edu	37	4	88091688	88091688	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr4:88091688C>T	uc011cdb.1	-	7	1673	c.1288G>A	c.(1288-1290)GTG>ATG	p.V430M	KLHL8_uc003hql.1_Missense_Mutation_p.V430M|KLHL8_uc003hqm.1_Missense_Mutation_p.V354M|KLHL8_uc003hqn.1_Missense_Mutation_p.V247M|KLHL8_uc010ikj.1_Missense_Mutation_p.V79M	NM_020803	NP_065854	Q9P2G9	KLHL8_HUMAN	kelch-like 8	430	Kelch 3.										0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		TATCTCTCCACATCATTGAAG	0.428000													10	128					0	0	0.008291	0	0
TRIM60	166655	broad.mit.edu	37	4	165962517	165962517	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr4:165962517G>A	uc003iqy.1	+	3	1463	c.1293G>A	c.(1291-1293)ATG>ATA	p.M431I	TRIM60_uc010iqx.1_Missense_Mutation_p.M431I	NM_152620	NP_689833	Q495X7	TRI60_HUMAN	ring finger protein 129	431	B30.2/SPRY.					intracellular	zinc ion binding			skin(1)	1	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)		TTTATAATATGAATGATAGGT	0.373000													6	89					0	0	0.021553	0	0
ADCY2	108	broad.mit.edu	37	5	7520913	7520913	+	Silent	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr5:7520913C>T	uc003jdz.1	+	3	538	c.471C>T	c.(469-471)GAC>GAT	p.D157D		NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	157					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						ACATGCGAGACGCCATCATTG	0.547000													6	87					0	0	0.003080	0	0
C5orf42	65250	broad.mit.edu	37	5	37169185	37169185	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr5:37169185T>C	uc011cpa.1	-	34	7172	c.6941A>G	c.(6940-6942)CAT>CGT	p.H2314R	C5orf42_uc011coy.1_Missense_Mutation_p.H814R|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.H1389R|C5orf42_uc003jkr.1_Missense_Mutation_p.H347R	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	2314										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			CAAGTTCACATGATTAGGAAT	0.373000													11	92					0	0	0.016723	0	0
C7	730	broad.mit.edu	37	5	40934551	40934551	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr5:40934551G>A	uc003jmh.2	+	4	377	c.263G>A	c.(262-264)CGT>CAT	p.R88H	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	88	LDL-receptor class A.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				TGTGGAGAGCGTTTCAGGTGC	0.423000													27	170					0	0	0.012213	0	0
ATP6AP1L	92270	broad.mit.edu	37	5	81613927	81613927	+	Silent	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr5:81613927G>A	uc003khv.2	+	10	1808	c.483G>A	c.(481-483)CTG>CTA	p.L161L	ATP6AP1L_uc003khw.2_Silent_p.L161L	NM_001017971	NP_001017971	Q52LC2	VAS1L_HUMAN	ATPase, H+ transporting, lysosomal accessory	161	Helical; (Potential).				ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism				0						TCCTGCTGCTGGTGTTGGCCT	0.557000													5	70					0	0	0.014758	0	0
GPR98	84059	broad.mit.edu	37	5	90106376	90106376	+	Missense_Mutation	SNP	G	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr5:90106376G>T	uc003kju.2	+	74	15395	c.15299G>T	c.(15298-15300)AGG>ATG	p.R5100M	GPR98_uc003kjt.2_Missense_Mutation_p.R2806M|GPR98_uc003kjw.2_Missense_Mutation_p.R761M	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5100	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GTAGAAATTAGGGGATTACAA	0.333000													10	122					0.000978159	0.00102344	0.010729	1	0
SLCO6A1	133482	broad.mit.edu	37	5	101709135	101709135	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr5:101709135C>T	uc003knn.2	-	13	2253	c.2081G>A	c.(2080-2082)CGT>CAT	p.R694H	SLCO6A1_uc003kno.2_Missense_Mutation_p.R441H|SLCO6A1_uc003knp.2_Missense_Mutation_p.R694H|SLCO6A1_uc003knq.2_Missense_Mutation_p.R632H	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	694	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		CTCATTTAGACGACGTTTGTA	0.323000													12	120					0	0	0.020292	0	0
EGR1	1958	broad.mit.edu	37	5	137803725	137803725	+	Silent	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr5:137803725G>A	uc003ldb.1	+	2	1857	c.1587G>A	c.(1585-1587)TCG>TCA	p.S529S	EGR1_uc011cyu.1_Missense_Mutation_p.R186Q	NM_001964	NP_001955	P18146	EGR1_HUMAN	early growth response 1	529					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CAGGGCTTTCGGACATGACAG	0.512000													17	127					0	0	0.012319	0	0
PCDHB8	56128	broad.mit.edu	37	5	140558380	140558380	+	Missense_Mutation	SNP	C	G	G			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr5:140558380C>G	uc011dai.1	+	1	951	c.765C>G	c.(763-765)GAC>GAG	p.D255E	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	255	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCTCTGAGGACAGTCCAATAA	0.468000													28	159					0	0	0.010818	0	0
PCDHGC4	56098	broad.mit.edu	37	5	140865844	140865844	+	Silent	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr5:140865844G>A	uc003lky.1	+	1	1104	c.1104G>A	c.(1102-1104)GTG>GTA	p.V368V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc011dbb.1_Silent_p.V368V|PCDHGC5_uc011dbc.1_5'Flank|PCDHGC5_uc003lla.1_5'Flank	NM_018928	NP_061751	Q9Y5F7	PCDGL_HUMAN	protocadherin gamma subfamily C, 4 isoform 1	368	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGCACTGTGGTGGCACTTA	0.547000													9	77					0	0	0.008291	0	0
DIAPH1	1729	broad.mit.edu	37	5	140908744	140908744	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr5:140908744C>T	uc003llb.3	-	22	2914	c.2773G>A	c.(2773-2775)GTG>ATG	p.V925M	DIAPH1_uc011dbd.1_5'Flank|DIAPH1_uc003llc.3_Missense_Mutation_p.V916M|DIAPH1_uc010jgc.1_Missense_Mutation_p.V361M	NM_005219	NP_005210	O60610	DIAP1_HUMAN	diaphanous 1 isoform 1	925	FH2.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCACCACCACGCCAAACTGC	0.512000													16	135					0	0	0.008871	0	0
SPINK5	11005	broad.mit.edu	37	5	147491350	147491350	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr5:147491350G>A	uc003lox.2	+	19	1785	c.1712G>A	c.(1711-1713)CGT>CAT	p.R571H	SPINK5_uc010jgs.1_Missense_Mutation_p.R543H|SPINK5_uc010jgr.2_Missense_Mutation_p.R552H|SPINK5_uc003low.2_Missense_Mutation_p.R571H|SPINK5_uc003loy.2_Missense_Mutation_p.R571H	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	571	Kazal-like 9.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity	p.R571C(1)		skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTGAATATCGTCATTATGTG	0.433000													17	79					0	0	0.027356	0	0
FAM71B	153745	broad.mit.edu	37	5	156589802	156589802	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr5:156589802G>A	uc003lwn.2	-	2	1574	c.1474C>T	c.(1474-1476)CGA>TGA	p.R492*		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	492						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GAGCCATGTCGCTTGCCCCTT	0.512000													16	109					0	0	0.006122	0	0
CDSN	1041	broad.mit.edu	37	6	31083952	31083952	+	Silent	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr6:31083952G>A	uc003nsm.1	-	2	1467	c.1440C>T	c.(1438-1440)TCC>TCT	p.S480S	PSORS1C1_uc003nsl.1_Intron|PSORS1C1_uc010jsj.1_Intron	NM_001264	NP_001255	Q15517	CDSN_HUMAN	corneodesmosin precursor	480					cell-cell adhesion|keratinocyte differentiation|skin morphogenesis	cornified envelope|desmosome|extracellular region	protein homodimerization activity			ovary(1)|pancreas(1)	2						TGGCACCAGCGGAGGGATCAG	0.622000													9	52					0	0	0.004482	0	0
MICB	4277	broad.mit.edu	37	6	31473999	31473999	+	Silent	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr6:31473999C>T	uc003ntn.3	+	3	521	c.405C>T	c.(403-405)TAC>TAT	p.Y135Y	MICB_uc011dnm.1_Silent_p.Y103Y|MICB_uc003nto.3_Intron	NM_005931	NP_005922	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	135	Extracellular (Potential).				antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding				0						ATTTCTACTACGATGGGGAGC	0.552000													4	46					0	0	0.009096	0	0
ROS1	6098	broad.mit.edu	37	6	117686238	117686238	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr6:117686238G>A	uc003pxp.1	-	20	3302	c.3103C>T	c.(3103-3105)CGA>TGA	p.R1035*	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1035	Fibronectin type-III 4.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TCAGGTGCTCGAAGTGACAGA	0.378000			T	GOPC|ROS1	glioblastoma|NSCLC								13	81					0	0	0.016723	0	0
GARS	2617	broad.mit.edu	37	7	30651808	30651808	+	Missense_Mutation	SNP	T	G	G			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr7:30651808T>G	uc003tbm.2	+	8	1335	c.978T>G	c.(976-978)ATT>ATG	p.I326M		NM_002047	NP_002038	P41250	SYG_HUMAN	glycyl-tRNA synthetase	326					cell death|diadenosine tetraphosphate biosynthetic process|glycyl-tRNA aminoacylation	cytosol|mitochondrial matrix|soluble fraction	ATP binding|glycine-tRNA ligase activity|protein dimerization activity			ovary(1)	1					Glycine(DB00145)	CTGCCCAGATTGGAAATTCTT	0.423000													9	84					0	0	0.006214	0	0
MAGI2	9863	broad.mit.edu	37	7	77885614	77885614	+	Missense_Mutation	SNP	G	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr7:77885614G>T	uc003ugx.2	-	10	1947	c.1693C>A	c.(1693-1695)CCG>ACG	p.P565T	MAGI2_uc003ugy.2_Missense_Mutation_p.P565T|MAGI2_uc010ldx.1_Missense_Mutation_p.P174T|MAGI2_uc010ldy.1_Missense_Mutation_p.P174T|MAGI2_uc011kgr.1_Missense_Mutation_p.P397T|MAGI2_uc011kgs.1_Missense_Mutation_p.P402T	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	565						cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GAATGAGGCGGCCGATCTGTT	0.507000													7	98					1.06961e-07	1.16218e-07	0.003080	1	0
PCLO	27445	broad.mit.edu	37	7	82584245	82584245	+	Silent	SNP	T	C	C			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr7:82584245T>C	uc003uhx.2	-	5	6313	c.6024A>G	c.(6022-6024)ACA>ACG	p.T2008T	PCLO_uc003uhv.2_Silent_p.T2008T	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1939					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TCTGGAGGTCTGTAATTTTCT	0.368000													3	131					0	0	0.004672	0	0
LAMB4	22798	broad.mit.edu	37	7	107732214	107732214	+	Missense_Mutation	SNP	G	A	A	rs143703672		TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr7:107732214G>A	uc010ljo.1	-	14	1642	c.1558C>T	c.(1558-1560)CCC>TCC	p.P520S	LAMB4_uc003vey.2_Missense_Mutation_p.P520S	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	520	Laminin EGF-like 5; truncated.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						CCATTCTTGGGTGAGCACCTG	0.493000													7	111					0	0	0.006214	0	0
EPHX2	2053	broad.mit.edu	37	8	27382881	27382881	+	Missense_Mutation	SNP	C	T	T	rs76549048		TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr8:27382881C>T	uc003xfu.2	+	12	1142	c.1061C>T	c.(1060-1062)GCG>GTG	p.A354V	EPHX2_uc010lut.1_Missense_Mutation_p.A354V|EPHX2_uc010luu.2_Missense_Mutation_p.A322V|EPHX2_uc010luv.2_Missense_Mutation_p.A288V|EPHX2_uc003xfv.2_Missense_Mutation_p.A301V|EPHX2_uc010luw.2_Missense_Mutation_p.A288V	NM_001979	NP_001970	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	354	Epoxide hydrolase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			ovary(1)	1		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	TTCTGTAGGGCGGTGGCCAGT	0.393000													9	128					0	0	0.004482	0	0
KIF13B	23303	broad.mit.edu	37	8	28981588	28981588	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr8:28981588C>T	uc003xhh.3	-	27	3364	c.3305G>A	c.(3304-3306)CGT>CAT	p.R1102H	uc003xhi.1_Intron	NM_015254	NP_056069	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	1102	Potential.				microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		GTACTCCTGACGTTTTGTTAA	0.343000													5	39					0	0	0.003080	0	0
WRN	7486	broad.mit.edu	37	8	30938764	30938764	+	Silent	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr8:30938764G>A	uc003xio.3	+	9	2009	c.1221G>A	c.(1219-1221)CAG>CAA	p.Q407Q	WRN_uc011lbd.1_Silent_p.Q110Q|WRN_uc011lbe.1_5'Flank	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	407					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		TTTTGGAACAGCAGTCTCAGG	0.313000			Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				6	78					0	0	0.001984	0	0
RP1	6101	broad.mit.edu	37	8	55533746	55533746	+	Missense_Mutation	SNP	G	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr8:55533746G>T	uc003xsd.1	+	2	368	c.220G>T	c.(220-222)GTG>TTG	p.V74L	RP1_uc011ldy.1_Missense_Mutation_p.V74L	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	74	Doublecortin 1.				axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GTCCAGGAAGGTGCCCCTCCC	0.597000													11	169					9.05144e-12	1.01269e-11	0.016723	1	0
CYP7A1	1581	broad.mit.edu	37	8	59409693	59409693	+	Silent	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr8:59409693G>A	uc003xtm.3	-	3	441	c.378C>T	c.(376-378)AAC>AAT	p.N126N		NM_000780	NP_000771	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A,	126					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				TGAAAGTGTCGTTTATGTTTT	0.443000									Neonatal_Giant_Cell_Hepatitis				6	87					0	0	0.004482	0	0
Unknown	0	broad.mit.edu	37	9	90746621	90746621	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr9:90746621G>A	uc011lti.1	-	4	1360	c.1331C>T	c.(1330-1332)CCA>CTA	p.P444L						SubName: Full=cDNA FLJ59639;																		AGGACTGACTGGAAAGTTCTC	0.498000													8	141					0	0	0.013537	0	0
SYK	6850	broad.mit.edu	37	9	93637110	93637110	+	Missense_Mutation	SNP	A	G	G			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr9:93637110A>G	uc004aqz.2	+	9	1365	c.1160A>G	c.(1159-1161)AAG>AGG	p.K387R	SYK_uc004ara.2_Missense_Mutation_p.K364R|SYK_uc004arb.2_Missense_Mutation_p.K364R|SYK_uc004arc.2_Missense_Mutation_p.K387R|SYK_uc011ltr.1_RNA|SYK_uc011lts.1_RNA|SYK_uc011ltt.1_RNA	NM_003177	NP_003168	P43405	KSYK_HUMAN	spleen tyrosine kinase isoform 1	387	Protein kinase.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						ACTGTGAAAAAGGGCTACTAC	0.473000			T	ETV6|ITK	MDS|peripheral T-cell lymphoma								3	122					0	0	0.004672	0	0
FAM47C	442444	broad.mit.edu	37	X	37028425	37028425	+	Missense_Mutation	SNP	A	G	G	rs145580328	byFrequency	TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chrX:37028425A>G	uc004ddl.1	+	1	1956	c.1942A>G	c.(1942-1944)AAT>GAT	p.N648D		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	648										ovary(3)	3						GGAGCCTCCCAATACTGGAGT	0.642000													5	147					0	0	0.021553	0	0
ZXDA	7789	broad.mit.edu	37	X	57934557	57934557	+	Silent	SNP	C	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chrX:57934557C>T	uc004dve.2	-	1	2511	c.2298G>A	c.(2296-2298)CAG>CAA	p.Q766Q		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	766					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						TTTCTCCCTCCTGTCCAAAGA	0.468000													4	121					0	0	0.014758	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994960	140994960	+	Silent	SNP	G	A	A			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chrX:140994960G>A	uc004fbt.2	+	4	2056	c.1770G>A	c.(1768-1770)CTG>CTA	p.L590L	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	590							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGGACTCCCTGTCTCCTCACT	0.567000										HNSCC(15;0.026)			8	635					0	0	0.010729	0	0
PI4KB	5298	broad.mit.edu	37	1	151265427	151265428	+	Frame_Shift_Ins	INS	-	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr1:151265427_151265428insT	uc001ext.2	-	12	2766_2767	c.2351_2352insA	c.(2350-2352)CAGfs	p.Q784fs	PI4KB_uc001exr.2_Frame_Shift_Ins_p.Q796fs|PI4KB_uc001exs.2_Frame_Shift_Ins_p.Q769fs|PI4KB_uc001exu.2_Frame_Shift_Ins_p.Q769fs|PI4KB_uc010pcw.1_Frame_Shift_Ins_p.Q452fs	NM_002651	NP_002642	Q9UBF8	PI4KB_HUMAN	catalytic phosphatidylinositol 4-kinase beta	784					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			ovary(2)|skin(2)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GCAGCTGCAGCTGCTCCTCAGT	0.550													19	76	---	---	---	---					
RPTN	126638	broad.mit.edu	37	1	152128709	152128712	+	Frame_Shift_Del	DEL	TGTC	-	-			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr1:152128709_152128712delTGTC	uc001ezs.1	-	3	928_931	c.863_866delGACA	c.(862-867)AGACAAfs	p.R288fs		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	288_289	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						ACTCTGGCCTTGTCTGTCTGTCTG	0.490													7	953	---	---	---	---					
ASXL2	55252	broad.mit.edu	37	2	26022304	26022306	+	In_Frame_Del	DEL	CTG	-	-			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr2:26022304_26022306delCTG	uc002rgs.2	-	4	572_574	c.351_353delCAG	c.(349-354)AGCAGT>AGT	p.117_118SS>S		NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	117_118	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCACCATCACTGCTGCTGCTGC	0.463													12	257	---	---	---	---					
PRDM15	63977	broad.mit.edu	37	21	43259793	43259794	+	Frame_Shift_Del	DEL	TC	-	-			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr21:43259793_43259794delTC	uc002yzq.1	-	14	2018_2019	c.1907_1908delGA	c.(1906-1908)AGAfs	p.R636fs	PRDM15_uc002yzo.2_Frame_Shift_Del_p.R307fs|PRDM15_uc002yzp.2_Frame_Shift_Del_p.R307fs|PRDM15_uc002yzr.1_Frame_Shift_Del_p.R307fs	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	636					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTTGGGTTTTCTCCCCCTTCG	0.599													17	394	---	---	---	---					
CLASP2	23122	broad.mit.edu	37	3	33602361	33602361	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr3:33602361delT	uc003cfu.2	-	27	3223	c.2869delA	c.(2869-2871)ATGfs	p.M957fs	CLASP2_uc003cfs.2_Frame_Shift_Del_p.M164fs|CLASP2_uc003cft.2_RNA|CLASP2_uc010hgb.2_RNA|CLASP2_uc011axt.1_Frame_Shift_Del_p.M557fs	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	966										ovary(3)|central_nervous_system(1)	4						TCAGCACCCATTTTTTTTAGT	0.343													7	187	---	---	---	---					
PDE12	201626	broad.mit.edu	37	3	57542756	57542757	+	Frame_Shift_Ins	INS	-	T	T			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr3:57542756_57542757insT	uc003diw.3	+	1	776_777	c.650_651insT	c.(649-651)TCTfs	p.S217fs	PDE12_uc003div.2_Frame_Shift_Ins_p.S217fs	NM_177966	NP_808881	Q6L8Q7	PDE12_HUMAN	phosphodiesterase 12	217							hydrolase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		TCGTCATTGTCTCCCTCCTCAC	0.594													43	275	---	---	---	---					
MIR567	693152	broad.mit.edu	37	3	111831724	111831724	+	RNA	DEL	A	-	-			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr3:111831724delA	hsa-mir-567|MI0003573	+			c.77delA			C3orf52_uc003dyq.3_Intron|C3orf52_uc011bhs.1_Intron|C3orf52_uc011bht.1_Intron|C3orf52_uc003dyr.1_Intron																	0						ATGCAAAACTAAAAAAAAAAA	0.323													3	3	---	---	---	---					
PROM1	8842	broad.mit.edu	37	4	15995680	15995680	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr4:15995680delT	uc003goo.2	-	15	1909	c.1697delA	c.(1696-1698)AATfs	p.N566fs	PROM1_uc003gor.2_Frame_Shift_Del_p.N566fs|PROM1_uc003gos.2_Frame_Shift_Del_p.N557fs|PROM1_uc003got.2_Frame_Shift_Del_p.N566fs|PROM1_uc003gou.2_Frame_Shift_Del_p.N557fs|PROM1_uc003gop.2_Frame_Shift_Del_p.N557fs|PROM1_uc003goq.3_Frame_Shift_Del_p.N557fs	NM_006017	NP_006008	O43490	PROM1_HUMAN	prominin 1 isoform 1	566	Extracellular (Potential).				camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	7						AGTGCCTCTATTTTTTTTGCA	0.428													8	172	---	---	---	---					
FRG1	2483	broad.mit.edu	37	4	190876218	190876219	+	Frame_Shift_Ins	INS	-	AT	AT			TCGA-FG-7643-01A-11D-2086-08	TCGA-FG-7643-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9bf459ac-bd93-4bca-a642-fd64e9eb6783	d0e20b08-cf3b-41e9-a116-5f157de4a40b	g.chr4:190876218_190876219insAT	uc003izs.2	+	5	535_536	c.344_345insAT	c.(343-345)AAAfs	p.K115fs		NM_004477	NP_004468	Q14331	FRG1_HUMAN	FSHD region gene 1	115					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus					0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		GGCTATGGAAAATATCTTGGTA	0.361													7	141	---	---	---	---					
