Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TNFRSF9	3604	broad.mit.edu	37	1	7998823	7998823	+	Missense_Mutation	SNP	C	T	T	rs9657963	byFrequency	TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr1:7998823C>T	uc001aot.2	-	3	294	c.166G>A	c.(166-168)GCA>ACA	p.A56T		NM_001561	NP_001552	Q07011	TNR9_HUMAN	tumor necrosis factor receptor superfamily,	56	TNFR-Cys 2.|Extracellular (Potential).				induction of apoptosis|negative regulation of cell proliferation	integral to plasma membrane	binding|receptor activity			large_intestine(1)|lung(1)|ovary(1)|skin(1)	4	Ovarian(185;0.0634)|all_lung(157;0.151)	all_epithelial(116;9.63e-21)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.000625)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.93e-71)|GBM - Glioblastoma multiforme(8;3.72e-37)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;7.71e-06)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000419)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00103)|READ - Rectum adenocarcinoma(331;0.0649)		TGTCCACCTGCGCTGGAGAAA	0.408000													16	132					0	0	0.006122	0	0
DNAJC6	9829	broad.mit.edu	37	1	65858364	65858364	+	Silent	SNP	T	G	G			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr1:65858364T>G	uc001dcd.1	+	12	1712	c.1548T>G	c.(1546-1548)GCT>GCG	p.A516A	DNAJC6_uc001dcc.1_Silent_p.A547A|DNAJC6_uc010opc.1_Silent_p.A503A|DNAJC6_uc001dce.1_Silent_p.A573A	NM_014787	NP_055602	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	516	Pro-rich.				cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			large_intestine(1)|lung(1)|ovary(1)	3						CGCCAGCGGCTCCTCCCACCA	0.582000													5	44					0	0	0.001984	0	0
PRG4	10216	broad.mit.edu	37	1	186276306	186276306	+	Silent	SNP	T	C	C	rs78867190	byFrequency	TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr1:186276306T>C	uc001gru.3	+	7	1506	c.1455T>C	c.(1453-1455)ACT>ACC	p.T485T	PRG4_uc001grt.3_Silent_p.T444T|PRG4_uc009wyl.2_Silent_p.T392T|PRG4_uc009wym.2_Silent_p.T351T|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	485	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|18; approximate.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CTGCACCCACTGCCCCCAAGA	0.652000													5	93					0	0	0.001984	0	0
PPRC1	23082	broad.mit.edu	37	10	103906760	103906760	+	Missense_Mutation	SNP	G	C	C			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr10:103906760G>C	uc001kum.2	+	9	4050	c.4011G>C	c.(4009-4011)TTG>TTC	p.L1337F	PPRC1_uc001kun.2_Missense_Mutation_p.L1217F|PPRC1_uc010qqj.1_Intron|PPRC1_uc009xxa.2_Intron	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	1337					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		TCTTGTCCTTGGGCCCAGCTG	0.607000													3	71					0	0	0.009096	0	0
FERMT3	83706	broad.mit.edu	37	11	63988497	63988497	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr11:63988497C>T	uc001nyl.2	+	13	1716	c.1567C>T	c.(1567-1569)CGG>TGG	p.R523W	FERMT3_uc001nym.2_Missense_Mutation_p.R519W	NM_178443	NP_848537	Q86UX7	URP2_HUMAN	fermitin family homolog 3 long form	523	FERM.				integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			ovary(1)	1						GCTCACCCCACGGATCCTGGA	0.652000													7	104					0	0	0.004482	0	0
EXPH5	23086	broad.mit.edu	37	11	108381318	108381318	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr11:108381318C>T	uc001pkk.2	-	6	5027	c.4916G>A	c.(4915-4917)TGC>TAC	p.C1639Y	EXPH5_uc010rvy.1_Missense_Mutation_p.C1451Y|EXPH5_uc010rvz.1_Missense_Mutation_p.C1483Y|EXPH5_uc010rwa.1_Missense_Mutation_p.C1563Y	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1639					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CAGTGGGTTGCACTCCACTGT	0.483000													48	37					0	0	0.014410	0	0
PRB2	653247	broad.mit.edu	37	12	11546009	11546009	+	Missense_Mutation	SNP	T	G	G			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr12:11546009T>G	uc010shk.1	-	3	1038	c.1003A>C	c.(1003-1005)AAA>CAA	p.K335Q		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			CCTTGAGGTTTGTTGCCTCCT	0.612000													6	222					0	0	0.008871	0	0
LRIG3	121227	broad.mit.edu	37	12	59276787	59276787	+	Silent	SNP	G	A	A			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr12:59276787G>A	uc001sqr.2	-	12	1590	c.1344C>T	c.(1342-1344)TGC>TGT	p.C448C	LRIG3_uc009zqh.2_Silent_p.C388C|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	448	LRRCT.					integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			GCTGGCAATCGCACAAAAGGC	0.403000													3	57					0	0	0.000602	0	0
FLRT2	23768	broad.mit.edu	37	14	86089274	86089274	+	Silent	SNP	C	T	T	rs146568257	byFrequency	TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr14:86089274C>T	uc001xvr.2	+	2	2183	c.1416C>T	c.(1414-1416)AGC>AGT	p.S472S	FLRT2_uc010atd.2_Silent_p.S472S	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	472	Fibronectin type-III.|Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		GCATAGTCAGCGGTGAGAAGC	0.517000													40	90					0	0	0.014410	0	0
ADAM6	8755	broad.mit.edu	37	14	106209367	106209367	+	RNA	SNP	G	A	A			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr14:106209367G>A	uc010tyt.1	-	3625		c.58356C>T			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_Intron|uc001yse.2_5'UTR|uc001ysf.2_5'UTR|uc001ysg.1_RNA					Parts of antibodies, mostly variable regions.												0						TGCTCTTGGAGGAGGGTGCCA	0.672000													4	54					0	0	0.009096	0	0
TP53	7157	broad.mit.edu	37	17	7574012	7574012	+	Nonsense_Mutation	SNP	C	A	A	rs17882252		TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr17:7574012C>A	uc002gim.2	-	10	1209	c.1015G>T	c.(1015-1017)GAG>TAG	p.E339*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Nonsense_Mutation_p.E207*|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Nonsense_Mutation_p.E339*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	339	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Nuclear export signal.|Interaction with HIPK2.		E -> Q (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E339*(10)|p.0?(7)|p.E339fs*8(2)|p.E339Q(1)|p.?(1)|p.F338fs*6(1)|p.F338_E339>L(1)|p.E339fs*13(1)|p.I332fs*5(1)|p.E339K(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGAACATCTCGAAGCGCTCA	0.468000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	40					7.03913e-09	7.51907e-09	0.013537	1	0
TP53	7157	broad.mit.edu	37	17	7579311	7579311	+	Splice_Site	SNP	C	T	T			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr17:7579311C>T	uc002gim.2	-	4	569	c.375_splice	c.e4+1	p.T125_splice	TP53_uc002gig.1_Splice_Site_p.T125_splice|TP53_uc002gih.2_Splice_Site_p.T125_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Splice_Site_p.T125_splice|TP53_uc010cni.1_Splice_Site_p.T125_splice|TP53_uc002gij.2_Splice_Site_p.T125_splice|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Splice_Site_p.T86_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(11)|p.0?(7)|p.V73fs*9(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGCAACTGACCGTGCAAGTC	0.532000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			41	48					0	0	0.014410	0	0
CWC25	54883	broad.mit.edu	37	17	36958970	36958970	+	Silent	SNP	C	T	T			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr17:36958970C>T	uc002hqu.2	-	9	1299	c.1146G>A	c.(1144-1146)CGG>CGA	p.R382R	CWC25_uc010wdv.1_Silent_p.R319R|CWC25_uc010wdw.1_RNA|PIP4K2B_uc002hqs.2_5'Flank|PIP4K2B_uc010wdt.1_5'Flank	NM_017748	NP_060218	Q9NXE8	CWC25_HUMAN	coiled-coil domain containing 49	382											0						ACTTCCCATCCCGGGAGTCCA	0.547000													7	92					0	0	0.004482	0	0
MUC16	94025	broad.mit.edu	37	19	8987333	8987333	+	Silent	SNP	G	A	A			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr19:8987333G>A	uc002mkp.2	-	68	41958	c.41754C>T	c.(41752-41754)ACC>ACT	p.T13918T	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Silent_p.T735T|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13921	Extracellular (Potential).			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGACCACCCCGGCTAGGGCAG	0.597000													13	95					0	0	0.003163	0	0
PSG8	440533	broad.mit.edu	37	19	43262370	43262370	+	Missense_Mutation	SNP	C	A	A			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr19:43262370C>A	uc002ouo.2	-	3	591	c.493G>T	c.(493-495)GTG>TTG	p.V165L	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc010eim.2_RNA|PSG8_uc002oui.2_Missense_Mutation_p.V4L|PSG8_uc002ouh.2_Missense_Mutation_p.V165L|PSG8_uc010ein.2_Missense_Mutation_p.V43L|PSG8_uc002ouj.3_Intron|PSG8_uc002ouk.3_Missense_Mutation_p.V4L|PSG8_uc002oul.3_Missense_Mutation_p.V165L|PSG8_uc002oum.3_Intron|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Intron	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	165	Ig-like C2-type 1.					extracellular region					0		Prostate(69;0.00899)				GTTAAGCTCACAGCCTCCATG	0.537000													18	223					2.4624e-09	2.69146e-09	0.008871	1	0
ERCC1	2067	broad.mit.edu	37	19	45916941	45916941	+	Silent	SNP	A	T	T			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr19:45916941A>T	uc002pbs.1	-	9	983	c.837T>A	c.(835-837)CCT>CCA	p.P279P	ERCC1_uc002pbt.1_Silent_p.P255P|ERCC1_uc002pbu.1_Silent_p.P207P|ERCC1_uc002pbv.2_Silent_p.P279P	NM_001983	NP_001974	P07992	ERCC1_HUMAN	excision repair cross-complementing 1 isofrom 2	279					mitotic recombination|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|response to oxidative stress|transcription-coupled nucleotide-excision repair	cytoplasm|nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair complex	damaged DNA binding|endonuclease activity|protein C-terminus binding|protein domain specific binding|single-stranded DNA binding			ovary(2)	2		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0247)		TTACTTTCTGAGGGCCCAGGC	0.522000								NER					12	98					0	0	0.013537	0	0
LILRA1	11024	broad.mit.edu	37	19	55112237	55112237	+	Silent	SNP	C	T	T			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr19:55112237C>T	uc002qgh.1	+	10	1607	c.1425C>T	c.(1423-1425)CTC>CTT	p.L475L		NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	475	Helical; (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		TGGTGGTCCTCGGGATTCTGC	0.562000													6	69					0	0	0.001168	0	0
MYO3B	140469	broad.mit.edu	37	2	171509614	171509614	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr2:171509614T>C	uc002ufy.2	+	35	4152	c.4009T>C	c.(4009-4011)TCT>CCT	p.S1337P	MYO3B_uc002ufz.2_Missense_Mutation_p.S1310P|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_RNA|uc002ugc.1_Intron	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	1337					response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						AAAAGGAGACTCTTTTGCTCA	0.418000													6	56					0	0	0.003080	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								25	44					0	0	0.012213	0	0
RPL37A	6168	broad.mit.edu	37	2	217364056	217364056	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr2:217364056C>T	uc002vgf.2	+	2	145	c.67C>T	c.(67-69)CGG>TGG	p.R23W	RPL37A_uc002vgg.2_Missense_Mutation_p.R23W	NM_000998	NP_000989	P61513	RL37A_HUMAN	ribosomal protein L37a	23					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	metal ion binding|protein binding|structural constituent of ribosome			ovary(1)	1		Renal(323;0.0458)		Epithelial(149;3.51e-06)|all cancers(144;0.000249)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGCCTCCCTCCGGAAAATGGT	0.502000													7	77					0	0	0.001984	0	0
IGFBP2	3485	broad.mit.edu	37	2	217525369	217525369	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr2:217525369C>T	uc010zjt.1	+	4	661	c.511C>T	c.(511-513)CGG>TGG	p.R171W	IGFBP2_uc010zju.1_Missense_Mutation_p.R106W	NM_000597	NP_000588	P18065	IBP2_HUMAN	insulin-like growth factor binding protein 2,	178					positive regulation of activated T cell proliferation|regulation of cell growth|regulation of insulin-like growth factor receptor signaling pathway	extracellular space	insulin-like growth factor I binding|insulin-like growth factor II binding				0		Renal(323;0.0458)		Epithelial(149;2.9e-06)|all cancers(144;0.000223)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00968)		CAGTGCTGGCCGGAAGCCCCT	0.612000													10	53					0	0	0.013537	0	0
COL6A3	1293	broad.mit.edu	37	2	238277572	238277572	+	Missense_Mutation	SNP	A	G	G			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr2:238277572A>G	uc002vwl.2	-	10	4819	c.4534T>C	c.(4534-4536)TCC>CCC	p.S1512P	COL6A3_uc002vwo.2_Missense_Mutation_p.S1306P|COL6A3_uc010znj.1_Missense_Mutation_p.S905P	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1512	VWFA 8.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TTCAGTGGGGACCCCCCTCTG	0.562000													4	49					0	0	0.000602	0	0
C20orf26	26074	broad.mit.edu	37	20	20123549	20123549	+	Missense_Mutation	SNP	A	T	T			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr20:20123549A>T	uc002wru.2	+	9	984	c.908A>T	c.(907-909)GAG>GTG	p.E303V	C20orf26_uc010gcw.1_Missense_Mutation_p.E257V|C20orf26_uc010zse.1_Missense_Mutation_p.E303V|C20orf26_uc010zsf.1_Missense_Mutation_p.E303V	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	303										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		ATAGTCGAGGAGTTGCAGGAA	0.488000													4	13					0	0	0.001168	0	0
ZNF217	7764	broad.mit.edu	37	20	52192452	52192452	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr20:52192452T>C	uc002xwq.3	-	3	3122	c.2851A>G	c.(2851-2853)ATC>GTC	p.I951V	ZNF217_uc010gij.1_Missense_Mutation_p.I943V	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	951					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			AGTGATGTGATGCCTCTGACC	0.542000													6	76					0	0	0.004482	0	0
ADSL	158	broad.mit.edu	37	22	40762494	40762494	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr22:40762494G>A	uc003ayp.3	+	13	1482	c.1423G>A	c.(1423-1425)GTG>ATG	p.V475M	ADSL_uc003ays.3_Missense_Mutation_p.V416M|ADSL_uc003ayq.3_Missense_Mutation_p.V489M|ADSL_uc003ayr.3_Missense_Mutation_p.V251M|ADSL_uc003ayt.3_Missense_Mutation_p.V460M	NM_000026	NP_000017	P30566	PUR8_HUMAN	adenylosuccinate lyase isoform a	475					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			ovary(1)	1						ATATGAAAGCGTGATGAAGGT	0.358000													4	47					0	0	0.000602	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64526873	64526873	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr3:64526873C>T	uc003dmg.2	-	36	5451	c.5419G>A	c.(5419-5421)GGG>AGG	p.G1807R	ADAMTS9_uc011bfo.1_Missense_Mutation_p.G1779R|ADAMTS9_uc011bfp.1_Missense_Mutation_p.G718R	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1807	GON.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CGCCGGCTCCCGTTATAGGGA	0.473000													21	101					0	0	0.004656	0	0
LOC100133050	100133050	broad.mit.edu	37	5	99715528	99715528	+	RNA	SNP	C	T	T			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr5:99715528C>T	uc011cuw.1	-	4		c.382G>A				NR_027503				Homo sapiens glucuronidase, beta pseudogene (LOC100133050), non-coding RNA.												0						AGCGGACAGTCGAAGCCCTTC	0.607000													4	19					0	0	0.009096	0	0
BRD8	10902	broad.mit.edu	37	5	137501597	137501597	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr5:137501597T>C	uc003lcf.1	-	11	1253	c.1198A>G	c.(1198-1200)ATG>GTG	p.M400V	BRD8_uc003lcc.1_RNA|BRD8_uc011cyl.1_Missense_Mutation_p.M179V|BRD8_uc003lcg.2_Missense_Mutation_p.M473V|BRD8_uc003lci.2_Missense_Mutation_p.M403V|BRD8_uc003lch.2_Missense_Mutation_p.M294V|BRD8_uc011cym.1_Missense_Mutation_p.M384V|BRD8_uc010jer.1_Missense_Mutation_p.M369V|BRD8_uc011cyn.1_Missense_Mutation_p.M359V	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	400					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GCAATATCCATCTTCTCAGCC	0.458000													6	52					0	0	0.004482	0	0
CD109	135228	broad.mit.edu	37	6	74491008	74491008	+	Silent	SNP	T	C	C			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr6:74491008T>C	uc003php.2	+	17	2354	c.1929T>C	c.(1927-1929)GAT>GAC	p.D643D	CD109_uc010kaz.2_Silent_p.D643D|CD109_uc003phq.2_Silent_p.D643D|CD109_uc010kba.2_Silent_p.D566D	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	643	Bait region (approximate) (By similarity).					anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						TATTGACAGATGCAAACCTCA	0.323000													5	33					0	0	0.001168	0	0
MDN1	23195	broad.mit.edu	37	6	90397120	90397120	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr6:90397120C>T	uc003pnn.1	-	68	11509	c.11393G>A	c.(11392-11394)CGG>CAG	p.R3798Q		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	3798					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AAGATGTTTCCGCAAAGACAA	0.403000													7	50					0	0	0.013537	0	0
HIVEP2	3097	broad.mit.edu	37	6	143095693	143095693	+	Silent	SNP	T	C	C			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr6:143095693T>C	uc003qjd.2	-	5	926	c.183A>G	c.(181-183)GCA>GCG	p.A61A		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	61					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		CAAACAGTTGTGCTGATGCTG	0.498000													27	187					0	0	0.008361	0	0
UNC93A	54346	broad.mit.edu	37	6	167728856	167728856	+	Silent	SNP	C	T	T			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr6:167728856C>T	uc003qvq.2	+	8	1465	c.1290C>T	c.(1288-1290)TGC>TGT	p.C430C	UNC93A_uc003qvr.2_Silent_p.C388C	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	430						integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		TTGTGGAGTGCGTGGAGTCCA	0.542000													27	323					0	0	0.004289	0	0
FBXL18	80028	broad.mit.edu	37	7	5540405	5540405	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr7:5540405T>C	uc003soo.2	-	3	1589	c.1495A>G	c.(1495-1497)ATG>GTG	p.M499V	FBXL18_uc003son.3_Missense_Mutation_p.M499V	NM_024963	NP_079239	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	499										central_nervous_system(2)|ovary(1)	3		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		TTGCGGGGCATGGCGGAGGAG	0.672000													16	63					0	0	0.010504	0	0
ZNF727	442319	broad.mit.edu	37	7	63538609	63538609	+	Silent	SNP	A	G	G			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr7:63538609A>G	uc011kdm.1	+	4	1361	c.1182A>G	c.(1180-1182)AAA>AAG	p.K394K		NM_001159522	NP_001152994	A8MUV8	ZN727_HUMAN	zinc finger protein 727	394					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTGGAGAGAAACCCTACAAAT	0.373000													2	4					0	0	0.004672	0	0
TRPV6	55503	broad.mit.edu	37	7	142575445	142575445	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr7:142575445G>A	uc003wbx.1	-	3	524	c.308C>T	c.(307-309)CCG>CTG	p.P103L	TRPV6_uc003wbw.1_5'Flank|TRPV6_uc010lou.1_5'UTR	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	103	Interaction with calmodulin (By similarity).|Cytoplasmic (Potential).|ANK 2.				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					GACCAGCTCCGGGGCAGCCTC	0.577000													11	168					0	0	0.013537	0	0
CNTLN	54875	broad.mit.edu	37	9	17236520	17236520	+	Silent	SNP	G	A	A			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr9:17236520G>A	uc003zmz.2	+	5	809	c.783G>A	c.(781-783)CTG>CTA	p.L261L	CNTLN_uc003zmx.3_Silent_p.L261L|CNTLN_uc003zmy.2_Silent_p.L261L|CNTLN_uc010mio.2_5'UTR	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	261						centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		TAAATGACCTGGAGAAATTGA	0.368000													9	44					0	0	0.008291	0	0
TLR4	7099	broad.mit.edu	37	9	120475609	120475609	+	Silent	SNP	A	G	G			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr9:120475609A>G	uc004bjz.2	+	3	1494	c.1203A>G	c.(1201-1203)CTA>CTG	p.L401L	TLR4_uc004bka.2_Silent_p.L361L|TLR4_uc004bkb.2_Silent_p.L201L	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	401	LRR 12.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						CAACCAGCCTAAAGTATTTAG	0.388000													3	19					0	0	0.004672	0	0
CCDC22	28952	broad.mit.edu	37	X	49105641	49105641	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chrX:49105641C>T	uc004dnd.1	+	14	1709	c.1553C>T	c.(1552-1554)ACG>ATG	p.T518M	CCDC22_uc004dnc.1_RNA	NM_014008	NP_054727	O60826	CCD22_HUMAN	coiled-coil domain containing 22	518	Potential.									central_nervous_system(1)	1						TTGTCTGATACGAAGGAGCTT	0.577000													6	29					0	0	0.001168	0	0
VSIG4	11326	broad.mit.edu	37	X	65253475	65253475	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chrX:65253475G>A	uc004dwh.2	-	2	380	c.253C>T	c.(253-255)CGC>TGC	p.R85C	VSIG4_uc004dwi.2_Missense_Mutation_p.R85C|VSIG4_uc010nkq.1_Missense_Mutation_p.R85C|VSIG4_uc004dwj.2_Missense_Mutation_p.R85C|VSIG4_uc011moy.1_Missense_Mutation_p.R85C|VSIG4_uc004dwk.2_Missense_Mutation_p.R85C|VSIG4_uc004dwl.2_5'UTR	NM_007268	NP_009199	Q9Y279	VSIG4_HUMAN	V-set and immunoglobulin domain containing 4	85	Ig-like 1.|Extracellular (Potential).				complement activation, alternative pathway	integral to membrane	protein binding				0						ACATGCAGGCGGCCCTGGTAC	0.547000													17	59					0	0	0.007413	0	0
ATRX	546	broad.mit.edu	37	X	76845302	76845302	+	Splice_Site	SNP	A	G	G			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chrX:76845302A>G	uc004ecp.3	-	27	6449	c.6217_splice	c.e27+1	p.G2073_splice	ATRX_uc004ecq.3_Splice_Site_p.G2035_splice|ATRX_uc004eco.3_Splice_Site_p.G1858_splice	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1						DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTTGTAGCTCACCTTTATAAA	0.328000			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						3	8					0	0	0.004672	0	0
CUX2	23316	broad.mit.edu	37	12	111758235	111758237	+	In_Frame_Del	DEL	TCC	-	-			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr12:111758235_111758237delTCC	uc001tsa.1	+	17	2575_2577	c.2422_2424delTCC	c.(2422-2424)TCCdel	p.S813del		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	813	Poly-Ser.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GCCCTCGCTGTCCTCCTCCTCCT	0.749													8	105	---	---	---	---					
TCF12	6938	broad.mit.edu	37	15	57565437	57565438	+	Frame_Shift_Ins	INS	-	TTGAC	TTGAC			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr15:57565437_57565438insTTGAC	uc002aec.2	+	18	2167_2168	c.1883_1884insTTGAC	c.(1882-1884)CTTfs	p.L628fs	TCF12_uc010ugm.1_Intron|TCF12_uc010ugn.1_Frame_Shift_Ins_p.L648fs|TCF12_uc002aea.2_Frame_Shift_Ins_p.L652fs|TCF12_uc010bfs.2_Frame_Shift_Ins_p.L49fs|TCF12_uc002aeb.2_Frame_Shift_Ins_p.L652fs|TCF12_uc002aed.2_Frame_Shift_Ins_p.L628fs|TCF12_uc002aee.2_Frame_Shift_Ins_p.L458fs|TCF12_uc010bft.2_Frame_Shift_Ins_p.L482fs|TCF12_uc010ugo.1_Frame_Shift_Ins_p.L392fs|TCF12_uc010ugp.1_Frame_Shift_Ins_p.L285fs|TCF12_uc010ugq.1_Frame_Shift_Ins_p.L262fs	NM_207038	NP_996921	Q99081	HTF4_HUMAN	transcription factor 12 isoform b	628	Helix-loop-helix motif.				immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(2)|lung(1)	8		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		GCAGTCATCCTTAGTCTAGAAC	0.441			T	TEC	extraskeletal myxoid chondrosarcoma								9	52	---	---	---	---					
GRIN3B	116444	broad.mit.edu	37	19	1009186	1009188	+	In_Frame_Del	DEL	AGC	-	-			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr19:1009186_1009188delAGC	uc002lqo.1	+	9	2717_2719	c.2717_2719delAGC	c.(2716-2721)GAGCAG>GAG	p.Q912del	uc002lqp.1_RNA	NM_138690	NP_619635	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic,	912	Cytoplasmic (Potential).				ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity				0		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CCCGAGGTGGagcagcagcagca	0.680													2	4	---	---	---	---					
SERTAD1	29950	broad.mit.edu	37	19	40929409	40929411	+	In_Frame_Del	DEL	CTC	-	-			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr19:40929409_40929411delCTC	uc002ont.3	-	2	202_204	c.43_45delGAG	c.(43-45)GAGdel	p.E15del		NM_013376	NP_037508	Q9UHV2	SRTD1_HUMAN	SERTA domain containing 1	15					positive regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GAGGTTCCTTCTCCTCCTCCTCC	0.453													7	133	---	---	---	---					
SOBP	55084	broad.mit.edu	37	6	107956280	107956282	+	In_Frame_Del	DEL	GCC	-	-			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chr6:107956280_107956282delGCC	uc003prx.2	+	6	2736_2738	c.2232_2234delGCC	c.(2230-2235)CAGCCG>CAG	p.P751del		NM_018013	NP_060483	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog	751	Pro-rich.						metal ion binding			ovary(1)	1		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		CTCCCGAGCAgccgccgccgccg	0.522													3	5	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76890105	76890106	+	Frame_Shift_Ins	INS	-	CATA	CATA			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chrX:76890105_76890106insCATA	uc004ecp.3	-	17	5020_5021	c.4788_4789insTATG	c.(4786-4791)ATGGGCfs	p.M1596fs	ATRX_uc004ecq.3_Frame_Shift_Ins_p.M1558fs|ATRX_uc004eco.3_Frame_Shift_Ins_p.M1381fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1596_1597	Helicase ATP-binding.|ATP (Potential).				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTACCAAGGCCCATACAGTGGG	0.322			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						16	63	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76938654	76938655	+	Frame_Shift_Ins	INS	-	T	T			TCGA-FG-8182-01A-11D-2253-08	TCGA-FG-8182-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	2aeaab9f-4459-4be8-91e7-e0746cbd671c	705290ff-c3b5-4e53-956d-05fc3825ccb7	g.chrX:76938654_76938655insT	uc004ecp.3	-	9	2325_2326	c.2093_2094insA	c.(2092-2094)AAGfs	p.K698fs	ATRX_uc004ecq.3_Frame_Shift_Ins_p.K660fs|ATRX_uc004eco.3_Frame_Shift_Ins_p.K483fs|ATRX_uc004ecr.2_Frame_Shift_Ins_p.K630fs|ATRX_uc010nlx.1_Frame_Shift_Ins_p.K669fs|ATRX_uc010nly.1_Frame_Shift_Ins_p.K643fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	698					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TACGCTTATCCTTTTTTCTCAC	0.356			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						9	64	---	---	---	---					
