Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FUBP1	8880	broad.mit.edu	37	1	78429792	78429792	+	Nonsense_Mutation	SNP	A	T	T			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr1:78429792A>T	uc001dii.2	-	12	1085	c.996T>A	c.(994-996)TGT>TGA	p.C332*	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Nonsense_Mutation_p.C353*	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	332	KH 3.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						CAGCATGTTGACATCGGTCTG	0.328													21	66					0	0	0.693898	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	G	G	rs9424867		TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr1:145302714A>G	uc001end.3	+	8	1187	c.1152A>G	c.(1150-1152)TTA>TTG	p.L384L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_5'UTR|NBPF10_uc001emq.1_Silent_p.L113L	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527													4	51					0	0	0.217242	0	0
RPL31P11	641311	broad.mit.edu	37	1	161654693	161654693	+	RNA	SNP	A	G	G	rs1256287	by1000genomes	TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr1:161654693A>G	uc001gbc.2	-	1		c.350T>C				NR_002595				Homo sapiens cDNA clone IMAGE:6574909, containing frame-shift errors.												0						TAACCAAAGTATAGAGCTTAT	0.398													3	24					0	0	0.115264	0	0
CFH	3075	broad.mit.edu	37	1	196648911	196648911	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr1:196648911C>T	uc001gtj.3	+	6	1018	c.778C>T	c.(778-780)CCT>TCT	p.P260S	CFH_uc001gti.3_Missense_Mutation_p.P260S|CFH_uc009wyw.2_Missense_Mutation_p.P260S|CFH_uc009wyx.2_Missense_Mutation_p.P196S	NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	260	Sushi 4.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						GCGTCCGTTGCCTTCATGTGA	0.279													5	28					0	0	0.217242	0	0
CNST	163882	broad.mit.edu	37	1	246810446	246810446	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr1:246810446A>G	uc001ibp.2	+	9	1321	c.943A>G	c.(943-945)AAA>GAA	p.K315E	CNST_uc001ibo.3_Missense_Mutation_p.K315E	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	315					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						TTTAGAGAGTAAAACTTGTCT	0.388											OREG0014367	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	40					0	0	0.479597	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37419199	37419199	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr10:37419199G>A	uc001iza.1	+	3	334	c.235G>A	c.(235-237)GTA>ATA	p.V79I		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	135						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						TATAAATCTCGTAGATGTGTA	0.423													7	36					0	0	0.335167	0	0
FOXM1	2305	broad.mit.edu	37	12	2968215	2968215	+	Silent	SNP	C	T	T			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr12:2968215C>T	uc001qlf.2	-	9	2146	c.1881G>A	c.(1879-1881)ACG>ACA	p.T627T	uc001qld.2_Intron|FOXM1_uc001qle.2_Silent_p.T665T|FOXM1_uc001qlg.2_Silent_p.T612T|FOXM1_uc009zea.2_Silent_p.T612T|FOXM1_uc009zeb.2_Silent_p.T611T	NM_021953	NP_068772	Q08050	FOXM1_HUMAN	forkhead box M1 isoform 2	627					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			TGGCTGGGGGCGTGAGCCTCC	0.592													18	83					0	0	0.608945	0	0
USP30	84749	broad.mit.edu	37	12	109519737	109519737	+	Splice_Site	SNP	G	A	A			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr12:109519737G>A	uc010sxi.1	+	9	885	c.781_splice	c.e9-1	p.G261_splice	USP30_uc001tnu.3_Splice_Site_p.G230_splice|USP30_uc001tnw.3_5'Flank	NM_032663	NP_116052	Q70CQ3	UBP30_HUMAN	ubiquitin specific peptidase 30						ubiquitin-dependent protein catabolic process	integral to membrane|mitochondrial outer membrane	cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(1)	1						TCATGCTGTAGGGTCACCCAT	0.428													25	109					0	0	0.717897	0	0
CYP1A2	1544	broad.mit.edu	37	15	75042314	75042314	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr15:75042314C>T	uc002ayr.1	+	2	299	c.235C>T	c.(235-237)CGC>TGC	p.R79C		NM_000761	NP_000752	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A,	79				R -> S (in Ref. 2; AAA35738).	alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			ovary(3)|breast(1)	4					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	CCTGCAGATCCGCATTGGCTC	0.672													12	32					0	0	0.457914	0	0
USP31	57478	broad.mit.edu	37	16	23080559	23080559	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr16:23080559C>T	uc002dll.2	-	16	2867	c.2867G>A	c.(2866-2868)CGC>CAC	p.R956H	USP31_uc002dlk.2_Missense_Mutation_p.R228H|USP31_uc010vca.1_Missense_Mutation_p.R259H|USP31_uc010bxm.2_Missense_Mutation_p.R244H	NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	956	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		GTTCAATCTGCGGGTGTCCGA	0.552													12	113					0	0	0.479597	0	0
PRSS54	221191	broad.mit.edu	37	16	58324928	58324928	+	Missense_Mutation	SNP	G	T	T			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr16:58324928G>T	uc002enf.2	-	4	593	c.198C>A	c.(196-198)CAC>CAA	p.H66Q	PRSS54_uc002eng.2_Missense_Mutation_p.H66Q|PRSS54_uc010vie.1_Intron	NM_001080492	NP_001073961	Q6PEW0	PRS54_HUMAN	plasma kallikrein-like protein 4 precursor	66	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						CGAAAGCCAGGTGTGTGTACT	0.607													12	59					1.02788e-11	1.09877e-11	0.520397	1	0
ZNF443	10224	broad.mit.edu	37	19	12541141	12541141	+	Silent	SNP	C	T	T			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr19:12541141C>T	uc002mtu.2	-	4	2043	c.1845G>A	c.(1843-1845)CCG>CCA	p.P615P		NM_005815	NP_005806	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	615					induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						TACATTCATACGGGTTCTCTC	0.403													3	31					0	0	0.115264	0	0
ZNF709	163051	broad.mit.edu	37	19	12575498	12575498	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr19:12575498G>A	uc002mtv.3	-	4	1399	c.1238C>T	c.(1237-1239)ACT>ATT	p.T413I	ZNF709_uc002mtw.3_Missense_Mutation_p.T381I|ZNF709_uc002mtx.3_Missense_Mutation_p.T413I	NM_152601	NP_689814	Q8N972	ZN709_HUMAN	zinc finger protein 709 isoform a	413	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCCAGTGTGAGTTCTTTCATG	0.418													4	57					0	0	0.184627	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56704396	56704396	+	Nonsense_Mutation	SNP	C	T	T			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr19:56704396C>T	uc010ygh.1	-	1	26	c.26G>A	c.(25-27)TGG>TAG	p.W9*		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	9					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TCCCTGACCCCATGAGAGTGT	0.502													2	2					0	0	0.115264	0	0
CCT7	10574	broad.mit.edu	37	2	73478419	73478419	+	Nonsense_Mutation	SNP	C	G	G			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr2:73478419C>G	uc002siz.2	+	11	1371	c.1269C>G	c.(1267-1269)TAC>TAG	p.Y423*	CCT7_uc002sja.2_Nonsense_Mutation_p.Y219*|CCT7_uc010yrf.1_Nonsense_Mutation_p.Y379*|CCT7_uc010feu.2_Nonsense_Mutation_p.Y381*|CCT7_uc010yrg.1_Nonsense_Mutation_p.Y323*|CCT7_uc010yrh.1_Nonsense_Mutation_p.Y295*|CCT7_uc010yri.1_Nonsense_Mutation_p.Y336*	NM_006429	NP_006420	Q99832	TCPH_HUMAN	chaperonin containing TCP1, subunit 7 isoform a	423					'de novo' posttranslational protein folding		ATP binding|unfolded protein binding				0						TGCGGGATTACTCAAGGACTA	0.517													24	81					0	0	0.717897	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 								13	55					0	0	0.500413	0	0
DHX35	60625	broad.mit.edu	37	20	37634881	37634881	+	Silent	SNP	C	T	T			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr20:37634881C>T	uc002xjh.2	+	12	1115	c.1104C>T	c.(1102-1104)TAC>TAT	p.Y368Y	DHX35_uc010zwa.1_Silent_p.Y213Y|DHX35_uc010zwb.1_Silent_p.Y213Y|DHX35_uc010zwc.1_Silent_p.Y337Y	NM_021931	NP_068750	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	368	Helicase C-terminal.					catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			lung(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				TCCGAGCCTACAATCCCAGGA	0.522													60	239					0	0	0.870114	0	0
KLHL5	51088	broad.mit.edu	37	4	39088270	39088270	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr4:39088270C>T	uc003gts.2	+	5	1249	c.1174C>T	c.(1174-1176)CGT>TGT	p.R392C	KLHL5_uc003gtp.2_Missense_Mutation_p.R346C|KLHL5_uc003gtq.2_Missense_Mutation_p.R205C|KLHL5_uc003gtr.1_Missense_Mutation_p.R392C|KLHL5_uc003gtt.2_Missense_Mutation_p.R331C	NM_015990	NP_057074	Q96PQ7	KLHL5_HUMAN	kelch-like 5 isoform 1	392						cytoplasm|cytoskeleton	actin binding			ovary(1)	1						TACTTGGGTCCGTCATGATTT	0.388													5	42					0	0	0.217242	0	0
SRD5A1	6715	broad.mit.edu	37	5	6663021	6663021	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr5:6663021G>A	uc003jdw.2	+	4	845	c.655G>A	c.(655-657)GCG>ACG	p.A219T	SRD5A1_uc011cml.1_RNA|SRD5A1_uc011cmm.1_Missense_Mutation_p.A172T	NM_001047	NP_001038	P18405	S5A1_HUMAN	steroid-5-alpha-reductase 1	219	Helical; (Potential).				androgen biosynthetic process|cell differentiation|sex determination|sex differentiation	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|electron carrier activity				0					Dutasteride(DB01126)|Finasteride(DB01216)	TGTCCAAGGCGCGGCTTTTGC	0.408													22	69					0	0	0.654019	0	0
GRIA1	2890	broad.mit.edu	37	5	153175109	153175109	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr5:153175109T>C	uc003lva.3	+	14	2709	c.2344T>C	c.(2344-2346)TAC>CAC	p.Y782H	GRIA1_uc003luy.3_Intron|GRIA1_uc003luz.3_Missense_Mutation_p.Y687H|GRIA1_uc011dcv.1_Intron|GRIA1_uc011dcw.1_Intron|GRIA1_uc011dcx.1_Intron|GRIA1_uc011dcy.1_Missense_Mutation_p.Y792H|GRIA1_uc011dcz.1_Intron	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	782	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CAAATGGTGGTACGATAAAGG	0.473													8	34					0	0	0.335167	0	0
SLC34A1	6569	broad.mit.edu	37	5	176825109	176825109	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr5:176825109G>A	uc003mgk.3	+	13	1843	c.1742G>A	c.(1741-1743)CGC>CAC	p.R581H		NM_003052	NP_003043	Q06495	NPT2A_HUMAN	solute carrier family 34 (sodium phosphate),	581	Cytoplasmic (Potential).				phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCCTGCCTCGCTGGATGCAC	0.667													13	53					0	0	0.575678	0	0
SCAND3	114821	broad.mit.edu	37	6	28540669	28540669	+	Silent	SNP	G	A	A			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr6:28540669G>A	uc003nlo.2	-	4	3615	c.2997C>T	c.(2995-2997)TGC>TGT	p.C999C		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	999					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						gatgaatgaagcaatgtgttg	0													13	67					0	0	0.557998	0	0
TFAP2B	7021	broad.mit.edu	37	6	50807962	50807962	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr6:50807962C>A	uc003pag.2	+	6	1200	c.1034C>A	c.(1033-1035)ACA>AAA	p.T345K		NM_003221	NP_003212	Q92481	AP2B_HUMAN	transcription factor AP-2 beta	345					nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0	Lung NSC(77;0.156)					CGGCAGCACACAGACCCGAGT	0.517													12	72					7.03913e-09	7.27376e-09	0.411799	1	0
Unknown	0	broad.mit.edu	37	9	68414330	68414330	+	RNA	SNP	T	C	C			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr9:68414330T>C	uc004aex.2	+	1		c.885T>C								Homo sapiens mRNA; cDNA DKFZp564N0763 (from clone DKFZp564N0763).																		atgattaagcttagtgaagat	0.025													2	4					0	0	0.115264	0	0
CLIC2	1193	broad.mit.edu	37	X	154508571	154508571	+	Nonsense_Mutation	SNP	A	C	C			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chrX:154508571A>C	uc004fnf.2	-	5	699	c.449T>G	c.(448-450)TTA>TGA	p.L150*	CLIC2_uc010nvj.1_Nonsense_Mutation_p.L168*	NM_001289	NP_001280	O15247	CLIC2_HUMAN	chloride intracellular channel 2	150	GST C-terminal.|C-terminal.				signal transduction	chloride channel complex|cytoplasm|nucleus	voltage-gated chloride channel activity			large_intestine(1)|ovary(1)|skin(1)	3	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TGGGGTGTTTAAGTAGTCATC	0.408													16	14					0	0	0.575678	0	0
SPRR3	6707	broad.mit.edu	37	1	152975806	152975829	+	In_Frame_Del	DEL	CCAGGCTACACCAAGGTCCCTGAA	-	-	rs72704847	byFrequency	TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr1:152975806_152975829delCCAGGCTACACCAAGGTCCCTGAA	uc001fax.3	+	3	460_483	c.310_333delCCAGGCTACACCAAGGTCCCTGAA	c.(310-333)CCAGGCTACACCAAGGTCCCTGAAdel	p.PGYTKVPE104del	SPRR3_uc001faz.3_In_Frame_Del_p.PGYTKVPE104del|SPRR3_uc001fay.2_In_Frame_Del_p.PGYTKVPE96del	NM_005416	NP_005407	Q9UBC9	SPRR3_HUMAN	small proline-rich protein 3	104_111	9.|14 X 8 AA approximate tandem repeats.				keratinization|peptide cross-linking|wound healing	cytoplasm	protein binding|structural molecule activity			skin(1)	1	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGTCCCTGAGCCAGGCTACACCAAGGTCCCTGAACCAGGCAGCA	0.567													10	81	---	---	---	---					
FNBP4	23360	broad.mit.edu	37	11	47788664	47788669	+	In_Frame_Del	DEL	GGTGGT	-	-	rs59413596		TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr11:47788664_47788669delGGTGGT	uc009ylv.2	-	1	325_330	c.172_177delACCACC	c.(172-177)ACCACCdel	p.TT58del	FNBP4_uc001ngj.2_5'UTR|FNBP4_uc001ngl.2_RNA	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	58_59										ovary(1)	1						CAGTCACCGCGGTGGTGGTGGTCGTC	0.748													3	5	---	---	---	---					
YBX2	51087	broad.mit.edu	37	17	7197580	7197581	+	Frame_Shift_Ins	INS	-	G	G			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr17:7197580_7197581insG	uc002gfq.2	-	1	296_297	c.239_240insC	c.(238-240)CCGfs	p.P80fs		NM_015982	NP_057066	Q9Y2T7	YBOX2_HUMAN	Y box binding protein 2	80					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter|translational attenuation	cytoplasm|nucleus	DNA binding				0						GACTCCGGGCCGGGGGGGCGGG	0.777													2	4	---	---	---	---					
PIK3CA	5290	broad.mit.edu	37	3	178916938	178916940	+	In_Frame_Del	DEL	GAA	-	-			TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr3:178916938_178916940delGAA	uc003fjk.2	+	2	482_484	c.325_327delGAA	c.(325-327)GAAdel	p.E110del		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	110					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E109del(2)|p.G106_R108del(1)|p.E110K(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AGGCAACCGTGAAGAAAAGATCC	0.340		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			9	38	---	---	---	---					
SNAPC4	6621	broad.mit.edu	37	9	139277995	139277997	+	In_Frame_Del	DEL	GCT	-	-	rs35266724		TCGA-HT-7620-01A-11D-2253-08	TCGA-HT-7620-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3e2dba25-2fc2-4f3b-90f0-663e1576a6bf	1f1dbf44-a66f-478b-9efa-9e76ca91f4bc	g.chr9:139277995_139277997delGCT	uc004chh.2	-	15	1633_1635	c.1624_1626delAGC	c.(1624-1626)AGCdel	p.S542del		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	542					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CGTCCTCCTCgctgctgctgctg	0.473													5	3	---	---	---	---					
